thrombocytopenia

Summary

Summary: A decrease in the number of blood platelets.

Top Publications

  1. ncbi International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)
    S Miyakis
    St George Hospital, University of New South Wales, Sydney, Australia
    J Thromb Haemost 4:295-306. 2006
  2. ncbi Treatment and prevention of heparin-induced thrombocytopenia: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
    Theodore E Warkentin
    Hamilton Regional Laboratory Medicine Program, Hamilton Health Sciences, 237 Barton Street E, Hamilton, Ontario, Canada
    Chest 133:340S-380S. 2008
  3. pmc Fever with thrombocytopenia associated with a novel bunyavirus in China
    XUE JIE YU
    Chinese Center for Disease Control and Prevention, Beijing, China
    N Engl J Med 364:1523-32. 2011
  4. pmc Metagenomic analysis of fever, thrombocytopenia and leukopenia syndrome (FTLS) in Henan Province, China: discovery of a new bunyavirus
    Bianli Xu
    Center for Disease Control and Prevention of Henan Province, Zhengzhou, China
    PLoS Pathog 7:e1002369. 2011
  5. pmc Person-to-person transmission of severe fever with thrombocytopenia syndrome bunyavirus through blood contact
    Zhongtao Gai
    Jinan Infectious Disease Hospital, Shandong University, Jinan
    Clin Infect Dis 54:249-52. 2012
  6. ncbi Evolutionary and molecular analysis of the emergent severe fever with thrombocytopenia syndrome virus
    Tommy Tsan Yuk Lam
    Department of Zoology, University of Oxford, Oxford, United Kingdom
    Epidemics 5:1-10. 2013
  7. ncbi Genome-wide association study identified ITPA/DDRGK1 variants reflecting thrombocytopenia in pegylated interferon and ribavirin therapy for chronic hepatitis C
    Yasuhito Tanaka
    Department of Virology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Hum Mol Genet 20:3507-16. 2011
  8. pmc Impact of Plasmodium falciparum infection on haematological parameters in children living in Western Kenya
    Robert N Maina
    US Army Medical Research Unit Kenya Walter Reed Project, Nairobi, Kenya
    Malar J 9:S4. 2010
  9. ncbi Thrombocytopenia in malaria: who cares?
    Marcus Vinícius Guimarães Lacerda
    Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, AM, Brasil
    Mem Inst Oswaldo Cruz 106:52-63. 2011
  10. ncbi Sporadic case infected by severe fever with thrombocytopenia syndrome bunyavirus in a non-epidemic region of China
    Shibo Li
    Department of Infectious Diseases, Zhoushan Hospital, Zhejiang, China
    Biosci Trends 5:273-6. 2011

Detail Information

Publications356 found, 100 shown here

  1. ncbi International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)
    S Miyakis
    St George Hospital, University of New South Wales, Sydney, Australia
    J Thromb Haemost 4:295-306. 2006
    ..Based on this, we propose amendments to the Sapporo criteria. We also provide definitions on features of APS that were not included in the updated criteria...
  2. ncbi Treatment and prevention of heparin-induced thrombocytopenia: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
    Theodore E Warkentin
    Hamilton Regional Laboratory Medicine Program, Hamilton Health Sciences, 237 Barton Street E, Hamilton, Ontario, Canada
    Chest 133:340S-380S. 2008
    This chapter about the recognition, treatment, and prevention of heparin-induced thrombocytopenia (HIT) is part of the Antithrombotic and Thrombolytic Therapy: American College of Chest Physicians Evidence-Based Clinical Practice ..
  3. pmc Fever with thrombocytopenia associated with a novel bunyavirus in China
    XUE JIE YU
    Chinese Center for Disease Control and Prevention, Beijing, China
    N Engl J Med 364:1523-32. 2011
    ..of acute febrile illness in China since 2009 has led to the identification of a severe fever with thrombocytopenia syndrome (SFTS) with an unknown cause...
  4. pmc Metagenomic analysis of fever, thrombocytopenia and leukopenia syndrome (FTLS) in Henan Province, China: discovery of a new bunyavirus
    Bianli Xu
    Center for Disease Control and Prevention of Henan Province, Zhengzhou, China
    PLoS Pathog 7:e1002369. 2011
    Since 2007, many cases of fever, thrombocytopenia and leukopenia syndrome (FTLS) have emerged in Henan Province, China. Patient reports of tick bites suggested that infection could contribute to FTLS...
  5. pmc Person-to-person transmission of severe fever with thrombocytopenia syndrome bunyavirus through blood contact
    Zhongtao Gai
    Jinan Infectious Disease Hospital, Shandong University, Jinan
    Clin Infect Dis 54:249-52. 2012
    Severe fever with thrombocytopenia syndrome bunyavirus is a newly discovered bunyavirus with high pathogenicity to human. The transmission model has been largely uncharacterized...
  6. ncbi Evolutionary and molecular analysis of the emergent severe fever with thrombocytopenia syndrome virus
    Tommy Tsan Yuk Lam
    Department of Zoology, University of Oxford, Oxford, United Kingdom
    Epidemics 5:1-10. 2013
    In 2009, a novel Bunyavirus, called severe fever with thrombocytopenia syndrome virus (SFTSV) was identified in the vicinity of Huaiyangshan, China...
  7. ncbi Genome-wide association study identified ITPA/DDRGK1 variants reflecting thrombocytopenia in pegylated interferon and ribavirin therapy for chronic hepatitis C
    Yasuhito Tanaka
    Department of Virology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Hum Mol Genet 20:3507-16. 2011
    ..The aim of this study was to identify host factors associated with IFN-induced thrombocytopenia by genome-wide association study (GWAS)...
  8. pmc Impact of Plasmodium falciparum infection on haematological parameters in children living in Western Kenya
    Robert N Maina
    US Army Medical Research Unit Kenya Walter Reed Project, Nairobi, Kenya
    Malar J 9:S4. 2010
    ..The t study sought to elucidate the haematological changes in children infected with malaria and their impact on improved diagnosis and therapy of childhood malaria...
  9. ncbi Thrombocytopenia in malaria: who cares?
    Marcus Vinícius Guimarães Lacerda
    Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, AM, Brasil
    Mem Inst Oswaldo Cruz 106:52-63. 2011
    Despite not being a criterion for severe malaria, thrombocytopenia is one of the most common complications of both Plasmodium vivax and Plasmodium falciparum malaria...
  10. ncbi Sporadic case infected by severe fever with thrombocytopenia syndrome bunyavirus in a non-epidemic region of China
    Shibo Li
    Department of Infectious Diseases, Zhoushan Hospital, Zhejiang, China
    Biosci Trends 5:273-6. 2011
    We report here a clinical and molecular study on a case suffer from severe fever with thrombocytopenia syndrome (SFTS) due to a new type of bunyavirus, named SFTS bunyavirus (SFTSV), in Zhejiang Province China...
  11. ncbi Recent advances in the understanding and management of MYH9-related inherited thrombocytopenias
    Carlo L Balduini
    Department of Internal Medicine, IRCCS Policlinico San Matteo Foundation, University of Pavia, Pavia, Italy
    Br J Haematol 154:161-74. 2011
    MYH9-related disease (MYH9-RD) is one of the most frequent forms of inherited thrombocytopenia. It is transmitted in an autosomal dominant fashion and derives from mutations of MYH9, the gene for the heavy chain of non-muscle myosin IIA...
  12. pmc Histones induce rapid and profound thrombocytopenia in mice
    Tobias A Fuchs
    Immune Disease Institute, Boston, MA, USA
    Blood 118:3708-14. 2011
    ..Infused histones associated with platelets in vivo and caused a profound thrombocytopenia within minutes after administration...
  13. pmc Pathogenesis of emerging severe fever with thrombocytopenia syndrome virus in C57/BL6 mouse model
    Cong Jin
    Laboratory of Viral Hemorrhagic Fever, National Institute for Viral Disease Control and Prevention, China Center for Disease Control Beijing 102206, China
    Proc Natl Acad Sci U S A 109:10053-8. 2012
    The discovery of an emerging viral disease, severe fever with thrombocytopenia syndrome (SFTS), caused by SFTS virus (SFTSV), has prompted the need to understand pathogenesis of SFTSV...
  14. pmc Treatment and prevention of heparin-induced thrombocytopenia: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
    Lori Ann Linkins
    Department of Medicine, McMaster University, Juravinski Hospital, Rm M0118, 1280 Main St W, Hamilton, ON, L8S 4K1, Canada
    Chest 141:e495S-530S. 2012
    Heparin-induced thrombocytopenia (HIT) is an antibody-mediated adverse drug reaction that can lead to devastating thromboembolic complications, including pulmonary embolism, ischemic limb necrosis necessitating limb amputation, acute ..
  15. pmc ABT-199, a new Bcl-2-specific BH3 mimetic, has in vivo efficacy against aggressive Myc-driven mouse lymphomas without provoking thrombocytopenia
    Cassandra J Vandenberg
    Walter and Eliza Hall Institute of Medical Research, Melbourne, Vic, Australia
    Blood 121:2285-8. 2013
    ..However, their interaction with Bcl-xL provokes thrombocytopenia, which has proven to be the dose-limiting toxicity...
  16. ncbi Thrombocytopenia in early malaria is associated with GP1b shedding in absence of systemic platelet activation and consumptive coagulopathy
    Quirijn de Mast
    Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Br J Haematol 151:495-503. 2010
    b>Thrombocytopenia develops early in malaria, but the underlying mechanisms remain incompletely understood...
  17. ncbi Prognostic value of thrombocytopenia in African children with falciparum malaria
    Patrick Gerardin
    Service de Pediatrie, Hopital Principal, Dakar, Senegal
    Am J Trop Med Hyg 66:686-91. 2002
    b>Thrombocytopenia is a common finding in malaria, but its prognostic value has not been addressed in children...
  18. ncbi Changes in white blood cells and platelets in children with falciparum malaria: relationship to disease outcome
    Shamez Ladhani
    Centre for Geographical Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    Br J Haematol 119:839-47. 2002
    ..controls, and leucocytosis was strongly associated with younger age, deep breathing, severe anaemia, thrombocytopenia and death. The WCC was not associated with a positive blood culture...
  19. ncbi Immune thrombocytopenia: pathophysiologic and clinical update
    Roberto Stasi
    Department of Haematology, St George s Hospital, London, UK
    Semin Thromb Hemost 38:454-62. 2012
    Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by both reduced platelet survival and suppression of megakaryocyte and platelet development...
  20. pmc Inflammation induces hemorrhage in thrombocytopenia
    Tobias Goerge
    Immune Disease Institute, Harvard Medical School, Boston, MA, USA
    Blood 111:4958-64. 2008
    The role of platelets in hemostasis is to produce a plug to arrest bleeding. During thrombocytopenia, spontaneous bleeding is seen in some patients but not in others; the reason for this is unknown...
  21. ncbi Advances in the understanding of MYH9 disorders
    Shinji Kunishima
    Department of Advanced Diagnosis, Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
    Curr Opin Hematol 17:405-10. 2010
    ..The present review summarizes the recent advances in genetic diagnosis and our understanding of the pathogenetic mechanisms of MYH9 mutations and the development of nonhematological complications...
  22. ncbi Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis
    Irina Pleines
    Chair of Vascular Medicine, University Hospital Würzburg and Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, Josef Schneider Strasse 2, Wurzburg, Germany
    Blood 119:1054-63. 2012
    ..Together, these results establish RhoA as an important regulator of platelet function in thrombosis and hemostasis...
  23. ncbi Thrombocytopenia in malaria--correlation with type and severity of malaria
    U M Jadhav
    Critical Care Unit and Pathology Department, MGM New Bombay Hospital, Vashi, New Mumbai
    J Assoc Physicians India 52:615-8. 2004
    Malaria is a major health problem in the tropics with increased morbidity and mortality. Thrombocytopenia is a common finding in malaria...
  24. ncbi Thrombocytopenia in pregnancy: differential diagnosis, pathogenesis, and management
    Keith R McCrae
    Hematology Oncology, BRB3, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, 10900 Euclid Avenue, OH 44106 4937, USA
    Blood Rev 17:7-14. 2003
    b>Thrombocytopenia in pregnant women may result from a number of diverse etiologies...
  25. ncbi The role of platelets in the pathogenesis of cerebral malaria
    Dermot Cox
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland
    Cell Mol Life Sci 67:557-68. 2010
    ..There is a strong association between thrombocytopenia and outcome in malaria, suggesting a role for platelets in the pathogenesis of malaria...
  26. ncbi Thrombocytopenia associated with chronic liver disease
    Nezam Afdhal
    Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    J Hepatol 48:1000-7. 2008
    b>Thrombocytopenia (platelet count <150,000/microL) is a common complication in patients with chronic liver disease (CLD) that has been observed in up to 76% of patients...
  27. ncbi Mutations in ANKRD26 are responsible for a frequent form of inherited thrombocytopenia: analysis of 78 patients from 21 families
    Patrizia Noris
    Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo Foundation, University of Pavia, Piazzale Golgi, Pavia, Italy
    Blood 117:6673-80. 2011
    Until recently, thrombocytopenia 2 (THC2) was considered an exceedingly rare form of autosomal dominant thrombocytopenia and only 2 families were known...
  28. ncbi Position of nonmuscle myosin heavy chain IIA (NMMHC-IIA) mutations predicts the natural history of MYH9-related disease
    Alessandro Pecci
    Department of Internal Medicine, University of Pavia and Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, Policlinico San Matteo Foundation, Pavia, Italy
    Hum Mutat 29:409-17. 2008
    ..We demonstrated that all subjects with mutations in the motor domain of NMMHC-IIA present with severe thrombocytopenia and develop nephritis and deafness before the age of 40 years, while those with mutations in the tail domain ..
  29. ncbi Heterozygous ITGA2B R995W mutation inducing constitutive activation of the αIIbβ3 receptor affects proplatelet formation and causes congenital macrothrombocytopenia
    Shinji Kunishima
    Department of Advanced Diagnosis, Clinical Research Center, National Hospital Organization Nagoya Medical Center, 4 1 1 Sannomaru, Naka ku, Nagoya, Japan
    Blood 117:5479-84. 2011
    ..We propose that activating mutations in ITGA2B and ITGB3 represent the etiology of a subset of congenital macrothrombocytopenias...
  30. ncbi Deciphering the molecular and biologic processes that mediate histone deacetylase inhibitor-induced thrombocytopenia
    Mark J Bishton
    Cancer Therapeutics Program, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, VIC 3002, Australia
    Blood 117:3658-68. 2011
    Histone deacetylase inhibitor (HDACI)-induced thrombocytopenia (TCP) is a major dose-limiting toxicity of this new class of drugs...
  31. ncbi Heparin-induced thrombocytopenia: in vitro studies on the interaction of dabigatran, rivaroxaban, and low-sulfated heparin, with platelet factor 4 and anti-PF4/heparin antibodies
    Krystin Krauel
    Institut für Immunologie und Transfusionsmedizin, Universitä Greifswald, Sauerbruchstrasse, Greifswald, Germany
    Blood 119:1248-55. 2012
    ..immune complexes activate platelets, leading to the prothrombotic adverse drug reaction heparin-induced thrombocytopenia (HIT). HIT requires treatment with alternative anticoagulants...
  32. ncbi Licorice induced hypokalemia, edema, and thrombocytopenia
    M M Celik
    Department of Internal Medicine, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey
    Hum Exp Toxicol 31:1295-8. 2012
    ..In this case report, an association of hypokalemia, edema, and thrombocytopenia that is developed due to the excessive intake of licorice is presented...
  33. ncbi [Epidemiologic analysis on severe fever with thrombocytopenia syndrome in Hubei province, 2010]
    Li Liu
    Hubei Provincial Center for Disease Control and Prevention, Wuhan, China
    Zhonghua Liu Xing Bing Xue Za Zhi 33:168-72. 2012
    To identify the epidemic characteristics and risk factors of an emerging infectious disease-severe fever with thrombocytopenia syndrome (SFTS) in Hubei province.
  34. ncbi Mutations in MYH9 result in the May-Hegglin anomaly, and Fechtner and Sebastian syndromes. The May-Heggllin/Fechtner Syndrome Consortium
    M Seri
    Laboratory of Molecular Genetics, Institute G Gaslini, Genoa, Italy
    Nat Genet 26:103-5. 2000
    ..MHA; MIM 155100), Fechtner syndrome (FTNS; MIM 153640) and Sebastian syndrome (SBS), share the triad of thrombocytopenia, large platelets and characteristic leukocyte inclusions ('Döhle-like' bodies)...
  35. ncbi Thrombocytopenia resulting from mutations in filamin A can be expressed as an isolated syndrome
    Paquita Nurden
    Centre de Reference des Pathologies Plaquettaires, Plateforme Technologique d Innovation Biomédicale, Hopital Xavier Arnozan, Pessac, France
    Blood 118:5928-37. 2011
    ..Hemorrhage, coagulopathy, and thrombocytopenia are mentioned in several reports on patients with FLNA-PVNH...
  36. ncbi Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-alpha production in vivo
    Rukhsana Aslam
    Department of Laboratory Medicine and Pathobiology, St Michael s Hospital, 30 Bond St, Toronto, ON, Canada, M5B 1W8
    Blood 107:637-41. 2006
    ..LPS-resistant C3H/HeJ mice, functional TLR4 expression in vivo was shown to be responsible for LPS-induced thrombocytopenia. However, when the C3H/HeN mice were first rendered thrombocytopenic by an antiplatelet antibody and then ..
  37. pmc Thrombocytopenia in malaria
    Umang Patel
    Department of Medicine, Coney Island Hospital, Brooklyn, NY 11223, USA
    J Natl Med Assoc 96:1212-4. 2004
    ..A finding of thrombocytopenia should increase the suspicion of malaria and lead to performance of more specific tests, including multiple ..
  38. pmc ACTN1 mutations cause congenital macrothrombocytopenia
    Shinji Kunishima
    Department of Advanced Diagnosis, Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
    Am J Hum Genet 92:431-8. 2013
    ..Our findings provide an insight into the pathogenesis of CMTP...
  39. pmc Mutations in the 5' UTR of ANKRD26, the ankirin repeat domain 26 gene, cause an autosomal-dominant form of inherited thrombocytopenia, THC2
    Tommaso Pippucci
    Medical Genetics Unit, Department of Gynaecological, Obstetric, and Paediatric Sciences, University of Bologna, Bologna 40138, Italy
    Am J Hum Genet 88:115-20. 2011
    THC2, an autosomal-dominant thrombocytopenia described so far in only two families, has been ascribed to mutations in MASTL or ACBD5...
  40. pmc The trans-sialidase from Trypanosoma cruzi induces thrombocytopenia during acute Chagas' disease by reducing the platelet sialic acid contents
    Maria Virginia Tribulatti
    Instituto de Investigaciones Biotecnologicas, Universidad Nacional de San Martin, Predio INTI, Edificio 24, Av General Paz y Constituyentes, B1650WAB San Martín, Buenos Aires, Argentina
    Infect Immun 73:201-7. 2005
    Strong thrombocytopenia is observed during acute infection with Trypanosoma cruzi, the parasitic protozoan agent of American trypanosomiasis or Chagas' disease...
  41. pmc Imbalance of angiopoietin-1 and angiopoetin-2 in severe dengue and relationship with thrombocytopenia, endothelial activation, and vascular stability
    Meta Michels
    Department of General Internal Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands
    Am J Trop Med Hyg 87:943-6. 2012
    ..Dengue-associated thrombocytopenia and endothelial activation are associated with an imbalance in angiopoietin-2: angiopoietin-1 plasma levels...
  42. pmc Platelet formation
    Jonathan N Thon
    Translational Medicine Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Semin Hematol 47:220-6. 2010
    b>Thrombocytopenia is the underlying cause of a number of major clinical conditions and genetic disorders worldwide...
  43. pmc Delayed mortality and attenuated thrombocytopenia associated with severe malaria in urokinase- and urokinase receptor-deficient mice
    P F Piguet
    Department of Pathology, University of Geneva, Geneva CH 1211, Switzerland
    Infect Immun 68:3822-9. 2000
    ..SM was associated with a profound thrombocytopenia, which was attenuated in uPA(-/-) and uPAR(-/-) mice...
  44. ncbi Thrombocytopenia associated with dengue hemorrhagic fever responds to intravenous administration of anti-D (Rh(0)-D) immune globulin
    Reynaldo Angelo C de Castro
    De La Salle University Health Sciences Campus, Far Eastern University, Pediatric Hematology Philippine Children s Medical Center and Department of Pediatrics, Manila, Philippines
    Am J Trop Med Hyg 76:737-42. 2007
    Severe thrombocytopenia and increased vascular permeability are two major characteristics of dengue hemorrhagic fever (DHF)...
  45. pmc Platelet-induced clumping of Plasmodium falciparum-infected erythrocytes from Malawian patients with cerebral malaria-possible modulation in vivo by thrombocytopenia
    Samuel Crocodile Wassmer
    Malawi Liverpool Wellcome Trust Clinical Research Programme, Chichiri
    J Infect Dis 197:72-8. 2008
    ..Both thrombocytopenia and platelet-induced PRBC clumping are associated with severe malaria and, especially, with CM...
  46. ncbi Elevated profiles of Th22 cells and correlations with Th17 cells in patients with immune thrombocytopenia
    Yu Hu
    Department of Hematology, Qilu Hospital of Shandong University, Jinan 250012, PR China
    Hum Immunol 73:629-35. 2012
    ..However, the role of Th22 cells in the pathophysiology of immune thrombocytopenia (ITP) remains unclear...
  47. ncbi Hemodialysis effect on platelet count and function and hemodialysis-associated thrombocytopenia
    John T Daugirdas
    Department of Medicine, University of Illinois at Chicago School of Medicine, Chicago, IL 60612, USA
    Kidney Int 82:147-57. 2012
    ..in platelet count (50% or more) during dialysis was observed, resulting in mild degrees of predialysis thrombocytopenia. In only one case was the decrease in platelet count associated with bleeding...
  48. ncbi Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia
    W J Song
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Nat Genet 23:166-75. 1999
    ..Our findings support a model for FPD/AML in which haploinsufficiency of CBFA2 causes an autosomal dominant congenital platelet defect and predisposes to the acquisition of additional mutations that cause leukaemia...
  49. pmc Mac-1 (CD11b/CD18) links inflammation and thrombosis after glomerular injury
    Junichi Hirahashi
    Brigham and Women s Hospital, Department of Pathology, 77 Avenue Louis Pasteur, NRB752O, Boston, MA 02115, USA
    Circulation 120:1255-65. 2009
    ..Inflammation and thrombosis coexist in several disorders. Although it is recognized that leukocytes may induce a procoagulant state at sites of inflammation, the critical molecular determinants of this process remain largely unknown...
  50. ncbi Thrombocytopenia and outcome in critically ill patients with bloodstream infection
    Dominique M Vandijck
    Department of Intensive Care Medicine, Ghent University Hospital, Ghent, Belgium
    Heart Lung 39:21-6. 2010
    b>Thrombocytopenia is common in intensive care units (ICUs), and is associated with a poor prognosis...
  51. ncbi Management and outcome of 200 cases of fetomaternal alloimmune thrombocytopenia
    Cedric Ghevaert
    National Blood Service Cambridge, Cambridge and Oxford, Department of Haematology, University of Cambridge, Cambridge, UK
    Transfusion 47:901-10. 2007
    Fetomaternal alloimmune thrombocytopenia (FMAIT) is the commonest cause of severe thrombocytopenia in term neonates but its management remains controversial.
  52. ncbi The frequency and clinical significance of thrombocytopenia complicating critical illness: a systematic review
    Phil Hui
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Chest 139:271-8. 2011
    The epidemiology of thrombocytopenia in critically ill patients has not been well characterized...
  53. ncbi Thrombocytopenia in chronic hepatitis C
    Mihai Olariu
    National Institute of Infectious Diseases Prof Dr Matei Balş Bucharest, Romania
    J Gastrointestin Liver Dis 19:381-5. 2010
    b>Thrombocytopenia in patients with chronic hepatitis C may be the result of several factors: bone marrow inhibition, the decrease of liver thrombopoietin production and an autoimmune mechanism...
  54. ncbi Cell- rather than antibody-mediated immunity leads to the development of profound thrombocytopenia during experimental Plasmodium berghei malaria
    Irene Gramaglia
    La Jolla Bioengineering Institute, La Jolla, CA 92037, USA
    J Immunol 175:7699-707. 2005
    Experimental malarial thrombocytopenia can reach life-threatening levels and is believed to be due to Abs targeting platelets for destruction by the reticuloendothelial system...
  55. ncbi Anemia and thrombocytopenia in patients undergoing chemotherapy for solid tumors: a descriptive study of a large outpatient oncology practice database, 2000-2007
    Ying Wu
    Johnson and Johnson Pharmaceutical Services LLC, Malvern, Pennsylvania, USA
    Clin Ther 31:2416-32. 2009
    This study was conducted to evaluate data on chemotherapy-associated anemia and thrombocytopenia, and cycle delays in patients with cancer in a community oncology practice.
  56. ncbi Plasmodium vivax malaria presenting with severe thrombocytopenia
    Anju Aggarwal
    Department of Paediatrics, University College of Medical Sciences, Guru Teg Bahadur Hospital, Delhi, India
    J Trop Pediatr 51:120-1. 2005
    Haematological changes are common in malaria. Thrombocytopenia is a common finding in falciparum infection but rare in Plasmodium vivax...
  57. ncbi Thrombocytopenia in critically ill patients
    Marcel Levi
    Department Internal Medicine, Academic Medical Centre, Amsterdam, The Netherlands
    Semin Thromb Hemost 34:417-24. 2008
    ..Platelets are part of the first line of defense of the body against bleeding, hence, thrombocytopenia may increase the risk of hemorrhage...
  58. ncbi Syndromic mental retardation with thrombocytopenia due to 21q22.11q22.12 deletion: Report of three patients
    Eleni Katzaki
    Medical Genetics, University of Siena, Siena, Italy
    Am J Med Genet A 152:1711-7. 2010
    ..11q22.12 region encompassing the RUNX1 gene have been reported in nine patients presenting with syndromic thrombocytopenia and mental retardation...
  59. pmc Analysis of 12,517 inhabitants of a Sardinian geographic isolate reveals that predispositions to thrombocytopenia and thrombocytosis are inherited traits
    Ginevra Biino
    Institute of Molecular Genetics, CNR, Pavia, Italy
    Haematologica 96:96-101. 2011
    b>Thrombocytopenia is a common finding in several diseases but almost nothing is known about the prevalence of thrombocytopenia in the general population...
  60. ncbi Quantitative interpretation of optical density measurements using PF4-dependent enzyme-immunoassays
    T E Warkentin
    Department of Pathology and Molecular Medicine, Michael G DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada
    J Thromb Haemost 6:1304-12. 2008
    Many laboratories test for heparin-induced thrombocytopenia (HIT) using a PF4-dependent enzyme-immunoassay (EIA)...
  61. pmc Comparisons of anemia, thrombocytopenia, and neutropenia at initiation of HIV antiretroviral therapy in Africa, Asia, and the Americas
    Cynthia Firnhaber
    Department of Medicine Clinical HIV Research Unit, University of Witwatersrand, Postnet suite 176, Private Bag X2600, Johannesburg 2041, South Africa
    Int J Infect Dis 14:e1088-92. 2010
    ..individuals live in resource-constrained countries, there is little information about the frequency of hematological abnormalities such as anemia, neutropenia, and thrombocytopenia among individuals with advanced HIV-1 disease.
  62. pmc Dose of prophylactic platelet transfusions and prevention of hemorrhage
    Sherrill J Slichter
    Puget Sound Blood Center, Seattle, WA 98104 1256, USA
    N Engl J Med 362:600-13. 2010
    We conducted a trial of prophylactic platelet transfusions to evaluate the effect of platelet dose on bleeding in patients with hypoproliferative thrombocytopenia.
  63. ncbi Thrombocytopenia in falciparum malaria is associated with high concentrations of IL-10
    Climent Casals-Pascual
    Nuffield Department of Clinical Laboratory Sciences and National Blood Service Oxford Centre, John Radcliffe Hospital, Oxford, United Kingdom
    Am J Trop Med Hyg 75:434-6. 2006
    ..However, somewhat paradoxically, thrombocytopenia is not associated clearly with outcome...
  64. ncbi Platelet dysfunction in renal failure
    Paola Boccardo
    Mario Negri Institute for Pharmacological Research, Unit of Nephrology and Dialysis, Azienda Ospedaliera, Ospedali Riuniti di Bergamo, Bergamo, Italy
    Semin Thromb Hemost 30:579-89. 2004
    ..b>Thrombocytopenia, glomerular thrombosis, and thrombi in small arteries and glomerular capillaries are common pathological ..
  65. ncbi Thrombocytopenia in pregnancy
    Jeffrey A Levy
    United States Army Health Clinic, Friedberg, Germany
    J Am Board Fam Pract 15:290-7. 2002
    b>Thrombocytopenia, defined as a platelet count of less than 150,000/microL, has been more commonly diagnosed in pregnant women in the last 20 years because platelet counts are included with the automated blood cell counters...
  66. ncbi Cutaneous anthrax associated with microangiopathic hemolytic anemia and coagulopathy in a 7-month-old infant
    Abigail Freedman
    Department of Pediatrics, New York University Medical Center, 550 First Ave, New York, NY 10016, USA
    JAMA 287:869-74. 2002
    ..The systemic manifestations of the disease persisted for nearly a month despite corticosteroid therapy, but resolved...
  67. ncbi Low anticoagulant heparin targets multiple sites of inflammation, suppresses heparin-induced thrombocytopenia, and inhibits interaction of RAGE with its ligands
    Narayanam V Rao
    Department of Internal Medicine, University of Utah Medical Center, Salt Lake City, UT 84132, USA
    Am J Physiol Cell Physiol 299:C97-110. 2010
    ..ODSH does not interact with heparin-platelet factor-4 antibodies present in patients with heparin-induced thrombocytopenia and even suppresses platelet activation in the presence of activating concentrations of heparin...
  68. ncbi Mice lacking pituitary tumor transforming gene show testicular and splenic hypoplasia, thymic hyperplasia, thrombocytopenia, aberrant cell cycle progression, and premature centromere division
    Z Wang
    Department of Medicine, Cedars Sinai Research Institute, University of California Los Angeles School of Medicine, Los Angeles, California 90048, USA
    Mol Endocrinol 15:1870-9. 2001
    ..surprisingly, viable and fertile; but they have testicular and splenic hypoplasia, thymic hyperplasia, and thrombocytopenia. PTTG -/- mouse embryo fibroblasts exhibited aberrant cell cycle progression with prolonged G2-M phase and ..
  69. pmc Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis
    Roel H Wilting
    Division of Molecular Genetics, Plesmanlaan 121, Amsterdam, The Netherlands
    EMBO J 29:2586-97. 2010
    ..Dual inactivation of Hdac1 and Hdac2 results in apoptosis of megakaryocytes and thrombocytopenia. Together, these data indicate that Hdac1 and Hdac2 have overlapping functions in cell cycle regulation and ..
  70. ncbi Antiplatelet autoantibodies elicited by dengue virus non-structural protein 1 cause thrombocytopenia and mortality in mice
    D S Sun
    Institute of Molecular and Cellular Biology, Tzu Chi University, Hualien, Taiwan
    J Thromb Haemost 5:2291-9. 2007
    The mechanisms responsible for thrombocytopenia associated with dengue fever (DF) and dengue hemorrhage fever (DHF) remain unclear.
  71. pmc Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma
    Richard L Piekarz
    Departmentof Health and Human Services, Center for Cancer Researchand Cancer Therapy EvaluationProgram, National Cancer Institute, National Institutes of Health, Bethesda, USA
    J Clin Oncol 27:5410-7. 2009
    ..Toxicities included nausea, vomiting, fatigue, and transient thrombocytopenia and granulocytopenia. Pharmacokinetics were evaluated with the first administration of romidepsin...
  72. pmc Severe falciparum malaria in Gabonese children: clinical and laboratory features
    Arnaud Dzeing-Ella
    Department of Parasitology, Mycology and Tropical Medicine, Faculty of Medicine, University of Health Sciences USS, Libreville, Gabon
    Malar J 4:1. 2005
    ..This study examined the prognostic indicators of severe falciparum malaria in Gabonese children...
  73. ncbi Assessment of an immature platelet fraction (IPF) in peripheral thrombocytopenia
    Carol Briggs
    Department of Haematology, University College London Hospital, London, UK
    Br J Haematol 126:93-9. 2004
    ..The clinical utility of this parameter was established in the laboratory diagnosis of thrombocytopenia due to increased peripheral platelet destruction, particularly autoimmune thrombocytopenic purpura (AITP) and ..
  74. ncbi Deficiency in the Wiskott-Aldrich protein induces premature proplatelet formation and platelet production in the bone marrow compartment
    Siham Sabri
    Institut National de la Santé etde la Recherche Médicale INSERM, U790, Universite Paris XI, Institut Gustave Roussy, Villejut, France
    Blood 108:134-40. 2006
    ..pathophysiology of microthrombocytopenia in the Wiskott-Aldrich syndrome (WAS) and its milder form, X-linked thrombocytopenia (XLT), is unclear...
  75. ncbi Heparin-induced thrombocytopenia: pathogenesis and management
    Theodore E Warkentin
    Hamilton Regional Laboratory Medicine Program, Hamilton Health Sciences, Hamilton, Ontario, Canada
    Br J Haematol 121:535-55. 2003
  76. pmc Platelets prevent IFN-alpha/beta-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus
    Matteo Iannacone
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 105:629-34. 2008
    ....
  77. ncbi Lymphocyte apoptosis and thrombocytopenia in spleen during classical swine fever: role of macrophages and cytokines
    P J Sánchez-Cordón
    Departamento de Anatomia y Anatomia Patologica Comparadas, Facultad de Veterinaria, Universidad de Córdoba Edificio de Sanidad Animal, Campus de Rabanales, 14014, Cordoba, Spain
    Vet Pathol 42:477-88. 2005
    ..virus strain "Alfort" in order to identify the mechanism responsible for the lymphopenia and thrombocytopenia observed in the spleen during the experimental induction of disease, by immunohistochemical and ..
  78. ncbi Thrombocytopenia in the intensive care unit patient
    Andreas Greinacher
    Institut für Immunologie und Transfusionsmedizin, Universitatsklinikum, Ernst Moritz Arndt Universitat Greifswald, Greifswald, Germany
    Hematology Am Soc Hematol Educ Program 2010:135-43. 2010
    The many comorbidities in the severely ill patient also make thrombocytopenia very common (∼40%) in intensive care unit patients...
  79. ncbi Genetics of familial forms of thrombocytopenia
    Carlo L Balduini
    Department of Internal Medicine, University of Pavia IRCCS Policlinico San Matteo Foundation, Pavia, Italy
    Hum Genet 131:1821-32. 2012
    ..In this review, we provide a systematic description of hereditary thrombocytopenias as we know them today, giving special attention to genetic aspects...
  80. pmc Thrombocytopenia in vivax and falciparum malaria: an observational study of 131 patients in Karnataka, India
    K Saravu
    Kasturba Medical College, Manipal University, Karnataka, India
    Ann Trop Med Parasitol 105:593-8. 2011
    b>Thrombocytopenia has been reported in the majority of malaria studies. Some but not all studies suggest the possible role of platelets in the pathology of severe malaria...
  81. ncbi Rivaroxaban--an oral, direct Factor Xa inhibitor--has potential for the management of patients with heparin-induced thrombocytopenia
    Jeanine M Walenga
    Cardiovascular Institute, Loyola University Chicago, Maywood, IL 60153, USA
    Br J Haematol 143:92-9. 2008
    ..UFH) and low molecular weight heparins (LMWHs); however, their use can be restricted by heparin-induced thrombocytopenia (HIT)...
  82. ncbi Pathogenesis of chronic immune thrombocytopenia: increased platelet destruction and/or decreased platelet production
    Diane Nugent
    Department of Hematology, Children s Hospital of Orange County, Orange, CA, USA
    Br J Haematol 146:585-96. 2009
    Chronic immune thrombocytopenia (ITP) is a haematological disorder in which patients predominantly develop skin and mucosal bleeding. Early studies suggested ITP was primarily due to immune-mediated peripheral platelet destruction...
  83. ncbi Clinical and molecular predictors of thrombocytopenia and risk of bleeding in patients with von Willebrand disease type 2B: a cohort study of 67 patients
    Augusto B Federici
    Angelo Bianchi Bonomi Hemophilia Thrombosis Center, Department of Medicine and Medical Specialties, Istituti di Ricovero e Cura a Carattere Scientifico Maggiore Hospital, University of Milan, Italy
    Blood 113:526-34. 2009
    ..affinity for the platelet receptor glycoprotein Ib-alpha (GPIb-alpha) that may result in moderate to severe thrombocytopenia. We evaluated the prevalence and clinical and molecular predictors of thrombocytopenia in a cohort of 67 ..
  84. pmc Thrombocytopenia in Plasmodium vivax malaria is related to platelets phagocytosis
    Helena Cristina C Coelho
    Universidade do Estado do Amazonas, Manaus, Amazonas, Brazil
    PLoS ONE 8:e63410. 2013
    Although thrombocytopenia is a hematological disorder commonly reported in malarial patients, its mechanisms are still poorly understood, with only a few studies focusing on the role of platelets phagocytosis.
  85. pmc Cytokine-mediated disruption of lymphocyte trafficking, hemopoiesis, and induction of lymphopenia, anemia, and thrombocytopenia in anti-CD137-treated mice
    Liguo Niu
    Emory Vaccine Research Center, Emory University School of Medicine, Atlanta, GA 30329, USA
    J Immunol 178:4194-213. 2007
    ..Anti-CD137-treated mice developed lymphopenia, thrombocytopenia, and anemia, and had lowered levels of hemoglobin and increased numbers of reticulocytes.
  86. ncbi Thrombocytopenia exacerbates cholestasis-induced liver fibrosis in mice
    Takahiro Kodama
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Gastroenterology 138:2487-98, 2498.e1-7. 2010
    Circulating platelet counts gradually decrease in parallel with progression of chronic liver disease. Thrombocytopenia is a common complication of advanced liver fibrosis and is thought to be a consequence of the destruction of ..
  87. pmc Chronic lymphocytic leukemia and autoimmunity: a systematic review
    Kate Hodgson
    Institute of Hematology and Oncology, Department of Hematology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    Haematologica 96:752-61. 2011
    ..chronic lymphocytic leukemia and autoimmune cytopenias, particularly autoimmune hemolytic anemia and immune thrombocytopenia, is well established...
  88. ncbi High pentraxin-3 plasma levels associate with thrombocytopenia in acute Puumala hantavirus-induced nephropathia epidemica
    T K Outinen
    Department of Internal Medicine, Tampere University Hospital, P O Box 2000, 33521, Tampere, Finland
    Eur J Clin Microbiol Infect Dis 31:957-63. 2012
    ..They also had longer hospital stays (8 vs. 5 days, p = 0.015) compared to patients with low PTX3 level. High plasma PTX3 levels are associated with thrombocytopenia and the overall severity of NE.
  89. ncbi Rituximab-cyclophosphamide-dexamethasone combination in the management of autoimmune cytopenias associated with chronic lymphocytic leukemia
    J Rossignol
    Department of Hematology, Claude Huriez University Hospital, Lille, France
    Leukemia 25:473-8. 2011
    ..Diagnosis of AID was autoimmune hemolytic anemia (AIHA) in 26 (54%), autoimmune thrombocytopenia (AITP) in 9 (18.8%), Evan's syndrome in 8 (16.7%) and pure red cell aplasia (PRCA) in 5 patients (10.5%)...
  90. ncbi Strong association of hepatitis C virus (HCV) infection and thrombocytopenia: implications from a survey of a community with hyperendemic HCV infection
    Chong Shan Wang
    A Lein Community Health Center, Kaohsiung County, Taipei, Taiwan
    Clin Infect Dis 39:790-6. 2004
    The role of hepatitis C virus (HCV) infection in thrombocytopenia (defined as a platelet count of <100,000 platelets/ mu L) is unknown...
  91. ncbi Amelioration of murine immune thrombocytopenia by CD44 antibodies: a potential therapy for ITP?
    Andrew R Crow
    Canadian Blood Services, Toronto, ON, Canada
    Blood 117:971-4. 2011
    To explore the potential for monoclonal antibodies as a treatment for immune thrombocytopenia (ITP) and to further explore their mechanisms of action, we tested 8 monoclonal CD44 antibodies in murine ITP and found 4 antibodies that could ..
  92. ncbi Shaping of terminal megakaryocyte differentiation and proplatelet development by sphingosine-1-phosphate receptor S1P4
    Sven Golfier
    Department of Tumor Genetics and Immunogenetics, Max Delbruck Center for Molecular Medicine, Berlin, Germany
    FASEB J 24:4701-10. 2010
    ..The recovery of platelet numbers after experimental thrombocytopenia was significantly delayed in S1p4(-/-) mice...
  93. ncbi High incidence of vaproate-induced coagulation disorders in children receiving valproic acid: a prospective study
    Stephan Koenig
    Department of Pediatrics, Germany, Mannheim University Hospital, University of Heidelberg, Germany
    Blood Coagul Fibrinolysis 19:375-82. 2008
    ..Two children developed thrombocytopenia, and six children with initial normal von Willebrand factor showed acquired von Willebrand's disease...
  94. ncbi A spontaneous prothrombotic disorder resembling heparin-induced thrombocytopenia
    Theodore E Warkentin
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Med 121:632-6. 2008
    ..against the "self" protein, platelet factor 4 (PF4), bound to heparin-the cause of immune heparin-induced thrombocytopenia-are believed invariably to be triggered by preceding heparin therapy...
  95. ncbi IVS6+5G>A found in Wiskott-Aldrich syndrome and X-linked thrombocytopenia in a Korean family
    Seong Ho Yoon
    Department of Pediatrics, Hanyang University Medical Center, Seoul, Korea
    Pediatr Blood Cancer 58:297-9. 2012
    Wiskott-Aldrich syndrome (WAS) and X-linked thrombocytopenia (XLT) are caused by a mutation in the WAS gene on Xp11.22. We report two patients with IVS6+5G>A of WAS in a Korean family...
  96. ncbi Heparin-induced thrombocytopenia
    A Greinacher
    Institut für Immunologie und Transfusionsmedizin, Ernst Moritz Arndt Universitat Greifswald, Sauerbruchstr, Greifswald, Germany
    J Thromb Haemost 7:9-12. 2009
    Heparin-induced thrombocytopenia (HIT), typically occurring in the second week of heparin therapy, is an antibody-mediated adverse drug reaction associated with increased thrombotic risk...
  97. ncbi Thrombocytopenia in Plasmodium falciparum, Plasmodium vivax and mixed infection malaria: a study from Bikaner (Northwestern India)
    Dhanpat Kumar Kochar
    Department of Medicine, Kothari Medical and Research Institute, Bikaner, India
    Platelets 21:623-7. 2010
    The occurrence, relation and magnitude of thrombocytopenia in different species of malaria are not clearly defined...
  98. ncbi Mutation of MYH9, encoding non-muscle myosin heavy chain A, in May-Hegglin anomaly
    M J Kelley
    Department of Medicine, Duke University, Durham, North Carolina, USA
    Nat Genet 26:106-8. 2000
    ..anomaly (MHA) is an autosomal dominant macrothrombocytopenia of unclear pathogenesis characterized by thrombocytopenia, giant platelets and leukocyte inclusions...
  99. ncbi Coagulation abnormalities in patients who have liver disease
    James F Trotter
    Division of Gastroenterology Hepatology, University of Colorado Health Sciences Center, 4200 East 9th Avenue, B 154 Denver, CO 80262, USA
    Clin Liver Dis 10:665-78, x-xi. 2006
    ..of the most common coagulation problems encountered in patients who have end-stage liver disease, which are thrombocytopenia and impaired humoral coagulation as measured by prolongation of the prothrombin time and international ..
  100. ncbi Efficacy of low dose dexamethasone in severe thrombocytopenia caused by dengue fever: a placebo controlled study
    S A M Kularatne
    Department of Medicine, Faculty of Medicine, Peradeniya University, Peradeniya, Sri Lanka
    Postgrad Med J 85:525-9. 2009
    The use of corticosteroids in the management of thrombocytopenia in dengue fever remains untested.
  101. ncbi Identification of three in-frame deletion mutations in MYH9 disorders suggesting an important hot spot for small rearrangements in MYH9 exon 24
    Koji Miyazaki
    Department of Hematology, Kitasato University School of Medicine, 1 15 1 Kitasato, Sagamihara, 228 8555 Kanagawa, Japan
    Eur J Haematol 83:230-4. 2009
    ..These findings further our current understanding of the molecular pathogenesis underlying MYH9 disorders...

Research Grants76

  1. Immune Mechanisms in Heparin-Induced Thrombocytopenia/T*
    Michael Reilly; Fiscal Year: 2004
    Heparin-induced thrombocytopenia/thrombosis (HIT/T) is the most frequent cause of drug-induced antibody-mediated thrombocytopenia, a common cause of life-and limb-threatening platelet activation and thrombosis, and a model to study how an ..
  2. Development of biomimetic oligomers as anti-coagulant antagonists
    Richard Scott; Fiscal Year: 2007
    ..adverse events associated with the use of heparin as anti-coagulant therapy are bleeding and heparin-induced thrombocytopenia. Protamine, a small arginine-rich protein, is an effective antagonist that is used clinically to neutralize ..
  3. Oklahoma Autoimmunity Center of Excellence
    Judith A James; Fiscal Year: 2013
    ..Multiple sclerosis, rheumatoid arthritis, pediatric arthritis, insulin-dependent diabetes, idiopathic thrombocytopenia and pediatric lupus are other key disease emphases of the Clinical Center...
  4. Examination of the Final Stages of Platelet Production
    JONATHAN NOAH THON; Fiscal Year: 2013
    ..lay in investigating the mechanisms of PLT formation for the purpose of developing targeted therapies for thrombocytopenia. The ability to control in vitro megakaryocyte (MK) expansion and maturation into PLTs will result in an ..
  5. Novel Chaperone Mechanism for Platelet Disorder
    Zihai Li; Fiscal Year: 2010
    ..hematopoietic system did not negatively affect megakaryopoiesis but resulted in prolonged bleeding time, thrombocytopenia and giant platelet disorder that are clinically indistinguishable from human BSS...
  6. Human Platelet Defects in Transcription Factor RUNX1 Haplodeficiency
    ANGARA KONETI RAO; Fiscal Year: 2013
    ..RUNX1 haplodeficiency is associated with familial thrombocytopenia, impaired platelet function and predisposition to acute leukemia...
  7. Novel Glycosaminoglycan Ethers for Prevention of Metastasis
    Alana L Welm; Fiscal Year: 2011
    ..L-selectin, and heparanase inhibition, (2) determining safety by measuring anticoagulant and heparin-induced thrombocytopenia activities, and (3) evaluating inhibition of metastasis in two preclinical metastasis models...
  8. ANDV Induced Responses of Hypoxic Endothelial Cells
    Erich R Mackow; Fiscal Year: 2012
    ..ANDV primarily infects endothelial cells (ECs) and HPS is characterized by thrombocytopenia, hypoxia and acute pulmonary edema that leads to respiratory insufficiency...
  9. Novel Immunodeficiency caused by TFRC Mutation
    RAIF SALIM GEHA; Fiscal Year: 2013
    ..in TFRC in a novel primary immunodeficiency (PID) characterized by recurrent sinopulmonary infections, thrombocytopenia, agammaglobulinemia, absent memory B cells, defective T and B cell activation, and impaired megakaryocyte ..
  10. Novel Biomarkers Predictive of Heparin-Induced Thrombocytopenia
    Barbara A Konkle; Fiscal Year: 2010
    ..Heparin-induced thrombocytopenia (HIT) occurs in 1-5% of patients exposed to heparin, can have severe consequences with loss of limbs or life, ..
  11. Long-acting growth factors for treating the acute and long term effects of lethal
    Christie M Orschell; Fiscal Year: 2013
    ..These proteins are used to treat chemotherapy-related neutropenia and thrombocytopenia in cancer patients...
  12. Cell Death Regulation by Pro-Apoptotic BOK During Hematopoiesis
    Samuel G Katz; Fiscal Year: 2013
    ..Deregulation of apoptosis can result in excessive cellular demise such as in cytopenias (e.g. thrombocytopenia) or pathologic cellular survival as seen in hematologic cancers (e.g. follicular lymphoma)...
  13. GATA1 Mutation in Defective Erythropoiesis
    John D Crispino; Fiscal Year: 2013
    ..are associated with a spectrum of blood disorders, including congenital dyserythropoietic anemia and thrombocytopenia, porphyria, and Diamond-Blackfan Anemia (DBA)...
  14. Collaborative Pediatric Critical Care Research Network At Children's Hospital of
    Joseph A Carcillo; Fiscal Year: 2013
    ..Response / Prolonged Lymphopenia / Immuneparalysis Syndrome, and 3) the microvascular thrombosis related Thrombocytopenia Associated Multiple Organ Failure Syndrome...
  15. Development of ex vivo Expanded Megakaryocyte Progenitors for Platelet Recovery F
    Holger Karsunky; Fiscal Year: 2009
    ..cellular therapeutic of megakaryocyte progenitors (MKP) for the mitigation of irradiation-induced thrombocytopenia. These progenitors will be derived and expanded ex vivo from hematopoietic stem cells (HSC) (CD34+ cells) in ..
  16. Aberrant Platelet Mechanisms in Inherited Human Platelet Function Disorders
    ANGARA KONETI RAO; Fiscal Year: 2010
    ..in expression of myosin light chain 9 (MYL9, 70 fold decrease) and other genes in a patient with an inherited thrombocytopenia, impaired platelet responses (including myosin and pleckstrin phosphorylation and GPIIb-llla activation), and ..
  17. Effect of anti-S phase agents on human chromosomes
    Anindya Dutta; Fiscal Year: 2013
    ..hydroxyurea are in extensive use for the treatment of cancers and of hematological diseases such as essential thrombocytopenia, polycythemia vera and sickle cell anemia...
  18. Determination of a Mechanism for the Thrombocytopenia of WAS
    Ted S Strom; Fiscal Year: 2010
    The objective of this proposal is to test a potential mechanism for the thrombocytopenia of the Wiskott- Aldrich Syndrome (WAS)...
  19. MOLECULAR &CELLULAR MECHANISMS IN TRANSFUSION MEDICINE
    Peter J Newman; Fiscal Year: 2013
    ..the role of specific B lymphocyte populations in the cellular immune response underlying heparin-induced thrombocytopenia - studies that may transform our ability to diagnose and manage this complex bleeding and clotting disorder...
  20. Impaired integrin-dependent function of WASP-deficient platelets
    EILEEN REMOLD-O'DONNELL; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Patients with Wiskott-Aldrich syndrome (WAS) suffer from profound thrombocytopenia due to accelerated loss of intrinsically defective platelets. The exact mechanism of platelet loss is unknown...
  21. Parathyroid Hormone in Prevention and Mitigation of Thrombocytopenia
    AMELIA M BARTHOLOMEW; Fiscal Year: 2010
    ..Gy will develop the hematopoietic syndrome, in which radiation injury to the bone marrow will lead to anemia, thrombocytopenia, and infectious complications due to neutropenia...
  22. STAT3 Functional Defects and a Novel Therapeutic Approach for Hyper IgE Syndrome
    Hans Ochs; Fiscal Year: 2009
    ..The goal of this proposal is to define the molecular basis for classic WAS and its milder form, X-linked thrombocytopenia (XLT), and to study the many functions attributed to WASP in human and murine systems...
  23. Modeling TAR Microdeletion Syndrome in Mouse
    Christa Lese Martin; Fiscal Year: 2013
    ..One such low-penetrance CNV syndrome is Thrombocytopenia-absent radius (TAR) syndrome...
  24. Microparticles, a new player in cerebral malaria pathogenesis
    VALERY MADELEINE COMBES; Fiscal Year: 2013
    ..increase in MPs in patients with CM, and that the numbers of platelet MPs correlated with coma depth and thrombocytopenia. This finding also suggests that MPs function in human CM coagulopathy, which also correlates with the ..
  25. Endothelial Progenitor Cell Transplant to Accelerate Hematopoietic Recovery
    John P Chute; Fiscal Year: 2011
    ..CBT) in adults, delayed donor cell engraftment can result in profound and persistent neutropenia, thrombocytopenia and immune suppression leading to increased mortality risk...
  26. 2012 New Insights into Coagulation
    Eleanor Pollak; Fiscal Year: 2012
    ..Regarding these topics, we will hear about heparin- induced thrombocytopenia from Adam Cuker, MD, MS, and warfarin pharmacogenetics from Jorge Sepulveda, MD/PhD...
  27. Fluorescence Fluctuation Spectroscopy for von Willebrand Factor Multimer Analysis
    Michael J Levene; Fiscal Year: 2010
    ..classification, and monitoring, for elucidating specifics about the pathogenetic mechanism of thrombotic thrombocytopenia purpura (TTP), and as a new tool for assessment of coagulation or bleeding risk in a variety of common ..
  28. GENETIC ANALYSIS OF LUPUS AUTOIMMUNITY
    Judith James; Fiscal Year: 2000
    ..reminiscent of human lupus including proteinuria, red cell casts, renal insufficiency, hypoalbuminemia, thrombocytopenia, alopecia, and seizures...
  29. Improving the diagnosis of heparin-induced thrombocytopenia
    Adam Cuker; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Heparin-induced thrombocytopenia (HIT) is a potentially fatal prothrombotic complication of heparin therapy...
  30. Mechanisms of normal and abnormal platelet homeostasis
    Joel S Bennett; Fiscal Year: 2010
    ..Project 1, entitled "Understanding the mechanistic basis of heparin-induced thrombocytopenia (HIT)", tests the hypothesis that variations in platelet factor 4 (PF4) secretion are responsible for the ..
  31. Identification of novel inhibitors targeting entry of human cytomegalovirus
    Domenico Tortorella; Fiscal Year: 2013
    ..Current therapy against HCMV targets the viral DNA polymerase, but induces severe side effects (e.g. thrombocytopenia) and drug-resistant viral strains upon prolonged treatment...
  32. Determining Optimum Medical Therapy for ITP
    JAMES BRUCE BUSSEL; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Adults with Immune Thrombocytopenia (ITP) are usually treated initially with steroids. However, the great majority either do not improve or do no have a lasting response...
  33. ASDAMTS-13 and Inflammation
    TRUNG CHANH NGUYEN; Fiscal Year: 2012
    ..with increased risk of death, one with severe sepsis, a form of systemic inflammation, and the other with thrombocytopenia-associated multiple organ failure...
  34. Platelet adhesion to neutrophil extracellular DNA traps: role in thrombosis
    Denisa D Wagner; Fiscal Year: 2013
    ..2. To study NETs formation in vivo and examine the biological relevance of NETs to sepsis-induced thrombocytopenia and to deep vein thrombosis. To measure NETs biomarkers in samples from patients with thrombosis...
  35. Oral Agents to Stimulate Neutrophil Production
    SUSAN PARK PERRINE; Fiscal Year: 2010
    ..sources of therapeutics likely to be effective in preventing or reducing the development of neutropenia or thrombocytopenia when administered at times after acute exposure to radiation...
  36. Hepatic Lectin Receptors in Glycoprotein Homeostasis
    JAMEY MARTH; Fiscal Year: 2013
    ..This discovery included the finding that hepatocytes cause thrombocytopenia by AMR-dependent platelet clearance in the course of sepsis induced by Streptococcal pneumoniae (SPN)...
  37. Third Bone Marrow Failure Disease Scientific Symposium
    Richard M Stone; Fiscal Year: 2012
    ..When the marrow fails to produce blood cells, the resulting anemia, thrombocytopenia (shortage of platelets in the bloodstream), and neutropenia (neutrophil shortage) can lead to debilitating ..
  38. Complement inhibition as sepsis therapy
    Florea Lupu; Fiscal Year: 2013
    ..of complement during each of the two stages of sepsis, assess complement activation as a potential cause of thrombocytopenia in sepsis and identify organ- specific protective effects of complement inhibition during sepsis progression...
  39. Platelet activation by cocaine in HIV-1 patients involves IKK
    MICHELLE MEGAN KIEBALA; Fiscal Year: 2013
    ..studies have shown impaired platelet function and increased platelet activation during HIV infection, and thrombocytopenia is a platelet-related abnormality that is frequently associated with HIV infection...
  40. A Microfluidic Bone Marrow Niche for the Study of Hematopoiesis
    Ying Zheng; Fiscal Year: 2013
    ..Dysregulation of blood cell production leads to severe anemia, leukopenia, and thrombocytopenia, and produces substantial morbidity and mortality...
  41. Microenvironmental regulation of megakaryopoiesis and thrombopoiesis by SDF1
    LISA MADALEN NISWANDER; Fiscal Year: 2013
    ..b>Thrombocytopenia is a major clinical problem afflicting patients with a variety of conditions, and can be a life-threatening ..
  42. Regulation of Cardiac Signaling by Class I Histone Deacetylases
    Timothy McKinsey; Fiscal Year: 2013
    ..However, since pan-HDAC inhibition is associated with toxicities such as thrombocytopenia, the potential for translating these findings to the heart failure clinic remains unclear...
  43. The F-BAR protein CIP4 in WAS-dependent thrombocytopenia
    SETH JOEL COREY; Fiscal Year: 2012
    ..The Wiskott -Aldrich syndrome (WAS) is an X- linked disorder characterized by thrombocytopenia, immunodeficiency, eczema and an increased risk of lymphoma and autoimmunity...
  44. Role of AhR During Megakaryopoiesis
    STEPHAN CADET LINDSEY; Fiscal Year: 2011
    ..discovering novel therapeutic targets and approaches for treating Mk and platelet disorders such as essential thrombocytopenia, refractory thrombocytopenia in myelodysplastic syndromes, megakaryoblastic leukemia, and thrombocythemia...
  45. Transcriptional Control of Hemoglobin Synthesis
    Emery H Bresnick; Fiscal Year: 2013
    ..zinc finger that underlie congenital erythropoietic porphyria, X- linked grey platelet syndrome, and thrombocytopenia with ?-thalassemia afect GATA-1 activity...
  46. HEMORRHAGIC DISEASES
    RICHARD HERBERT ASTER; Fiscal Year: 2013
    ..This grant addresses IDR pathogenesis in the context of drug-induced immune thrombocytopenia (DITP), an IDR triggered by hundreds of widely used medications through several different mechanisms...
  47. Cytoskeletal Mechanisms of Platelet Formation
    Joseph E Italiano; Fiscal Year: 2013
    ..platelet formation, and lay the foundation for novel therapeutic approaches to accelerate platelet production in patients with thrombocytopenia, as well as strategies aimed at improving the in vitro generation of platelets for infusion.
  48. Safe And Effective Anti-CD154 Antibodies For Therapeutic Intervention
    Randolph J Noelle; Fiscal Year: 2013
    ..Autoimmunity. Clinical efficacy of ?CD154 treatment has been seen in Lupus and idiopathic thrombocytopenia. In addition, Principal Investigator Dr...
  49. Characterization of Immune Deficiency in Congenital Bone Marrow Failure Syndromes
    Troy R Torgerson; Fiscal Year: 2012
    ..anemia (FA), dyskeratosis congenita (DKC), Schwachman-Diamond syndrome (SDS), congenital amegakaryocytic thrombocytopenia, and others...
  50. Mechanism of Thrombosis in Heparin Induced Thrombocytopenia
    RAJ SUNDAR KASTHURI; Fiscal Year: 2013
    ..on understanding the mechanism by which activation of coagulation and thrombosis occurs in heparin induced thrombocytopenia (HIT)...
  51. A FAP-Activated Proteasome Inhibitor for Killing Solid Tumors
    Barry Jones; Fiscal Year: 2011
    ..effects of which sensory and motor dysfunction called peripheral neuropathy (PN) and deficiency in platelets (thrombocytopenia) are the most severe...
  52. BRIDGE TRIAL
    Thomas L Ortel; Fiscal Year: 2013
    ..Exclusion criteria include: mechanical heart valve;recent stroke or major bleed;severe renal insufficiency, thrombocytopenia;or planned surgery that precludes use of post-operative therapeutic-dose LMWH...
  53. BRIDGE TRIAL
    Victor Hasselblad; Fiscal Year: 2013
    ..Exclusion criteria include: mechanical heart valve;recent stroke or major bleed;severe renal insufficiency, thrombocytopenia;or planned surgery that precludes use of post-operative therapeutic-dose LMWH...
  54. Biosynthesis and Function of Lactosaminyl Glycans in Hematopoiesis
    Robert Sackstein; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Infection and bleeding secondary to neutropenia and thrombocytopenia, respectively, are the major causes of near-term morbidity and mortality from chemoradiotherapy...
  55. Protectan CBLB502
    Andrei Gudkov; Fiscal Year: 2009
    ..non-toxic radiation countermeasures that can increase survival of ARS victims and alleviate post-irradiation thrombocytopenia when administered at least 12-24 hours after a nuclear event...
  56. Transfusion Medicine/Hemostasis Core Clinical Center
    Thomas L Ortel; Fiscal Year: 2012
    ..trials are close to initiation looking at patients with hemophilia and inhibitors, TTP, and heparin-induced thrombocytopenia. Building on the progress to date, we propose to continue our commitment at Duke to the TMH Network by ..
  57. Development of a novel small molecule, UTL-5g, to treat oxaliplatin-induced throm
    Jiajiu Shaw; Fiscal Year: 2013
    ..like many other anticancer drugs, oxaliplatin has several significant side effects, most notably, thrombocytopenia. The use FOLFOX is well established and widely used for colorectal cancer...
  58. Expansion of intracranial hemorrhage by tPA after traumatic brain injury
    ABD ALROOF HIGAZI; Fiscal Year: 2013
    ..of newly formed blood clots in the brain: a) attenuates expansion of ICH, b) reduces D-Dimers, c) lessens thrombocytopenia, d) decreases tPA mediated neurotoxicity, and e) improves neurological outcome post TBI...
  59. Novel strategies to prevent FcgRIIA-dependent platelet activation and thrombosis
    Wolfgang Bergmeier; Fiscal Year: 2013
    ..Activation of the platelet Fc receptor, Fc?RIIA, is central to the pathogenesis of several immune- mediated thrombocytopenia and thrombosis (ITT) syndromes, including heparin-induced thrombocytopenia/thrombosis...
  60. Inhibition of Cardiac Device Induced Cellular Dysfunction in Pigs
    REKHA BANSAL; Fiscal Year: 2012
    ..These events can cause thrombosis, thrombocytopenia, and severe bleeding complications...
  61. Clinical Significance of protamine/heparin antibodies after CPB
    Gowthami M Arepally; Fiscal Year: 2012
    ..We will also establish the concurrent expression of PF4/H antibodies (causative antibodies in Heparin-Induced Thrombocytopenia or HIT) and determine if patients with PRT/H and PF4/H antibodies have worse outcomes...
  62. Immune correlates of steroid responsiveness in ITP
    ELINE TJETSKE LUNING PRAK; Fiscal Year: 2010
    ..Oral steroids are a standard first-line therapy for autoimmune disorders such as immune thrombocytopenia (ITP)...
  63. MGH Transfusion Medicine and Hemostasis Network Clinical Core Center
    David J Kuter; Fiscal Year: 2012
    ..The HOT Trial to assess the rate of thrombosis and complications of therapy for patients with heparin-induced thrombocytopenia (HIT);(d) The STAR Trial to determine the benefit of rituximab added to the usual treatment for TTP;and (e) ..
  64. MASTL kinase activity in megakaryocyte differentiation
    HELEN JANETTE JOHNSON; Fiscal Year: 2010
    ..point mutation was identified in the MASTL kinase in a family suffering with an inherited autosomal dominant thrombocytopenia. This observation has provided evidence for the involvement of this novel kinase in the megakaryocytopoeisis ..
  65. CONTROL OF HEMATOPOIETIC TOXICITY WITH INTERLEUKIN-1
    VINCENT GALLICCHIO; Fiscal Year: 1990
    ..Specifically, this toxicity results in the development of neutropenia and/or thrombocytopenia. The degree and extent of damage to the hematopoietic system usually is the major limiting factor that ..
  66. Study of TTP: Incidence Rates and Risk Factors
    Charles Bennett; Fiscal Year: 2005
    ..disease characterized by a pentad of symptoms including microangiopathic hemolytic anemia (MAHA), thrombocytopenia, neurologic symptoms, fever, and renal dysfunction...
  67. HEPARIN INDUCED THROMBOCYTOPENIA/THROMBOSIS
    GIAN VISENTIN; Fiscal Year: 2000
    Heparin-induced thrombocytopenia/thrombosis (HITP) is an important cause of morbidity and mortality in patients receiving heparin therapy...
  68. BIOLOGIC AND IMMUNOLOGIC ASPECTS OF TRANSFUSION MEDICINE
    Sherrill Slichter; Fiscal Year: 2009
    ..The target disease that he will use as a model for his system is congenital amegakaryocytic thrombocytopenia (CAMT). Two additional projects have an immunologic emphasis. Dr...
  69. Hematopoietic Stem Cells & Lympho-Hematopoiesis: Effect of Alcohol
    ROBERT WOLCOTT; Fiscal Year: 2007
    ..The deleterious effects of chronic alcohol include thrombocytopenia, neutropenia and lymphopenia, as well as pancytopenia...
  70. Analysis of clinical laboratory variables for early dengue illness classification
    James Potts; Fiscal Year: 2009
    ..dengue fever, DF);however, patients with dengue can manifest a more severe illness with bleeding tendency, thrombocytopenia, and plasma leakage (dengue hemorrhagic fever, DHF)...
  71. GENE EXPRESSION BY HUMAN GRANULOCYTIC EHRLICHIOSIS AG
    Yasuko Rikihisa; Fiscal Year: 2004
    ..HGE is a systemic febrile illness often accompanied by hematological abnormalities including leukopenia and thrombocytopenia. It frequently requires prolonged hospitalization and when the treatment is delayed due to misdiagnosis or in ..
  72. Reconstitution of thrombopoiesis by angiogenic factors
    Shahin Rafii; Fiscal Year: 2009
    ..reconstitute early phases of myelosuppression induced by irradiation, leading to prolonged life-threatening thrombocytopenia and bleeding complications...
  73. Megakaryocyte Chemokines & Post-Irradiation Thrombocytopenia
    Mortimer Poncz; Fiscal Year: 2009
    ..Germaine to this application, endogenous PF4 levels affect the degree and duration of thrombocytopenia following both chemo- and radiation-induced thrombocytopenia (CIT and RIT, respectively)...
  74. STUDIES OF MEGAKARYOCYTOPOIESIS
    Samuel Burstein; Fiscal Year: 1991
    ..if IL-3 has a role in megakaryocytopoiesis in vivo, expression of the IL-3 gene will be measured following thrombocytopenia induced by 1) administration of anti-platelet serum to mice; and 2) exchange transfusion of rats with ..
  75. SIV INFECTION EFFECT ON HEMATOPOIETIC STEM CELLS
    Christopher Hillyer; Fiscal Year: 1999
    Anemia, granulocytopenia, lymphopenia, and thrombocytopenia are common in HIV infection though the pathogenesis of these abnormalities is not well understood...
  76. PATHOGENESIS OF THROMBOCYTOPENIAS OF NEONATES
    Robert Christensen; Fiscal Year: 2002
    b>Thrombocytopenia is common among patients in Neonatal Intensive Care Units (NICU). In fact, 20-35 percent of NICU patients, or 80,000-120,000 neonates in the USA annually, develop thrombocytopenia at some time during their hospital stay...