blood coagulation disorders

Summary

Summary: Hemorrhagic and thrombotic disorders that occur as a consequence of abnormalities in blood coagulation due to a variety of factors such as COAGULATION PROTEIN DISORDERS; BLOOD PLATELET DISORDERS; BLOOD PROTEIN DISORDERS or nutritional conditions.

Top Publications

  1. pmc Thrombelastography and tromboelastometry in assessing coagulopathy in trauma
    Pär I Johansson
    Regional Blood Bank, Rigshospitalet, University of Copenhagen, Denmark
    Scand J Trauma Resusc Emerg Med 17:45. 2009
  2. ncbi Revisiting saw-scaled viper (Echis carinatus) bites in the Jaffna Peninsula of Sri Lanka: distribution, epidemiology and clinical manifestations
    S A M Kularatne
    Department of Medicine, Faculty of Medicine, University of Peradeniya, Kandy, Sri Lanka
    Trans R Soc Trop Med Hyg 105:591-7. 2011
  3. ncbi Pathophysiology and treatment of coagulopathy in massive hemorrhage and hemodilution
    Daniel Bolliger
    Department of Anaesthesia and Intensive Care Medicine, University of Basel Hospital, Basel, Switzerland
    Anesthesiology 113:1205-19. 2010
  4. ncbi Acute coagulopathy of trauma: balancing progressive catecholamine induced endothelial activation and damage by fluid phase anticoagulation
    P I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Med Hypotheses 75:564-7. 2010
  5. pmc Critical role of activated protein C in early coagulopathy and later organ failure, infection and death in trauma patients
    Mitchell Jay Cohen
    Department of Surgery, University of California San Francisco, San Francisco, CA 94110, USA
    Ann Surg 255:379-85. 2012
  6. ncbi Hydroxyethylstarch and gelatin solutions impair blood coagulation after cardiac surgery: a prospective randomized trial
    A Schramko
    Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Hospital, Meilahti Hospital, Helsinki HUS, Finland
    Br J Anaesth 104:691-7. 2010
  7. ncbi Coagulation abnormalities associated with severe isolated traumatic brain injury: cerebral arterio-venous differences in coagulation and inflammatory markers
    Michael Nekludov
    Department of Anesthesiology and Intensive Care, Karolinska University Hospital and Institutet, 17176 Stockholm, Sweden
    J Neurotrauma 24:174-80. 2007
  8. pmc Cardiovascular implications from untreated human immunodeficiency virus infection
    Jason V Baker
    Department of Medicine, Hennepin County Medical Center, University of Minnesota, 701 Park Ave, MC G5, Minneapolis, MN 55415, USA
    Eur Heart J 32:945-51. 2011
  9. pmc Saw-scaled viper bites in Sri Lanka: is it a different subspecies? Clinical evidence from an authenticated case series
    Ariaranee Gnanathasan
    Faculty of Medicine, University of Colombo, Kynsey Road, Colombo 08, Sri Lanka
    Am J Trop Med Hyg 86:254-7. 2012
  10. ncbi Pathogenesis of acute traumatic coagulopathy
    Ross Davenport
    Trauma Sciences, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, London, UK
    Transfusion 53:23S-27S. 2013

Detail Information

Publications252 found, 100 shown here

  1. pmc Thrombelastography and tromboelastometry in assessing coagulopathy in trauma
    Pär I Johansson
    Regional Blood Bank, Rigshospitalet, University of Copenhagen, Denmark
    Scand J Trauma Resusc Emerg Med 17:45. 2009
    ....
  2. ncbi Revisiting saw-scaled viper (Echis carinatus) bites in the Jaffna Peninsula of Sri Lanka: distribution, epidemiology and clinical manifestations
    S A M Kularatne
    Department of Medicine, Faculty of Medicine, University of Peradeniya, Kandy, Sri Lanka
    Trans R Soc Trop Med Hyg 105:591-7. 2011
    ..The median time for correction of coagulopathy was 802min (range 180-1669min) with Indian polyvalent antivenom. All recovered. The saw scaled viper is responsible for most venomous bites in the Jaffna peninsula...
  3. ncbi Pathophysiology and treatment of coagulopathy in massive hemorrhage and hemodilution
    Daniel Bolliger
    Department of Anaesthesia and Intensive Care Medicine, University of Basel Hospital, Basel, Switzerland
    Anesthesiology 113:1205-19. 2010
    ..Future clinical studies are necessary to establish the specific indication, dosing, and safety of novel hemostatic interventions...
  4. ncbi Acute coagulopathy of trauma: balancing progressive catecholamine induced endothelial activation and damage by fluid phase anticoagulation
    P I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Med Hypotheses 75:564-7. 2010
    ..The implications of this hypothesis may include targeted treatment strategies according to the degree of sympathoadrenal response as evaluated by whole blood viscoelastical hemostatic assays in trauma patients...
  5. pmc Critical role of activated protein C in early coagulopathy and later organ failure, infection and death in trauma patients
    Mitchell Jay Cohen
    Department of Surgery, University of California San Francisco, San Francisco, CA 94110, USA
    Ann Surg 255:379-85. 2012
    ..Whether this early coagulopathy and later propensity to infection, multiple organ failure and mortality are associated with the activation of PC pathway has not been demonstrated and constitutes the aim of this study...
  6. ncbi Hydroxyethylstarch and gelatin solutions impair blood coagulation after cardiac surgery: a prospective randomized trial
    A Schramko
    Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Hospital, Meilahti Hospital, Helsinki HUS, Finland
    Br J Anaesth 104:691-7. 2010
    ..Both hydroxyethylstarch (HES) and gelatin solutions impair haemostasis. We examined the impact and dose effect on coagulation of HES 130/0.4, gelatin, or Ringer's acetate solutions after cardiac surgery...
  7. ncbi Coagulation abnormalities associated with severe isolated traumatic brain injury: cerebral arterio-venous differences in coagulation and inflammatory markers
    Michael Nekludov
    Department of Anesthesiology and Intensive Care, Karolinska University Hospital and Institutet, 17176 Stockholm, Sweden
    J Neurotrauma 24:174-80. 2007
    ..IL-6 and activation of the complement system (C5b-9) co-vary with hemostatic parameters in TBI patients...
  8. pmc Cardiovascular implications from untreated human immunodeficiency virus infection
    Jason V Baker
    Department of Medicine, Hennepin County Medical Center, University of Minnesota, 701 Park Ave, MC G5, Minneapolis, MN 55415, USA
    Eur Heart J 32:945-51. 2011
    ..Ultimately, additional adjunctive treatment will be needed to mitigate premature CVD risk among contemporary HIV-infected patients with access to ART...
  9. pmc Saw-scaled viper bites in Sri Lanka: is it a different subspecies? Clinical evidence from an authenticated case series
    Ariaranee Gnanathasan
    Faculty of Medicine, University of Colombo, Kynsey Road, Colombo 08, Sri Lanka
    Am J Trop Med Hyg 86:254-7. 2012
    ....
  10. ncbi Pathogenesis of acute traumatic coagulopathy
    Ross Davenport
    Trauma Sciences, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, London, UK
    Transfusion 53:23S-27S. 2013
    ..TEG and ROTEM provide a rapid evaluation of clot dynamics in whole blood and are of greater value than coagulation screens in diagnosing and managing trauma hemorrhage...
  11. ncbi The influence of hemocoagulative disorders on the outcome of children with head injury
    A Chiaretti
    Pediatric Intensive Care Unit, Catholic University Medical School, I 00168 Rome, Italy
    Pediatr Neurosurg 34:131-7. 2001
    ..Although disseminated intravascular coagulation (DIC) and other hemocoagulative abnormalities are severe complications of head injury, their effect on clinical outcome remains unclear, particularly among children...
  12. pmc Early and individualized goal-directed therapy for trauma-induced coagulopathy
    Herbert Schöchl
    Ludwig Boltzmann Institute of Experimental and Clinical Traumatology, Vienna, Austria
    Scand J Trauma Resusc Emerg Med 20:15. 2012
    ..The concept of early, individualized and goal-directed therapy is explored in this review and the AUVA Trauma Hospital algorithm for managing trauma-induced coagulopathy is presented...
  13. pmc Disseminated intravascular coagulation or acute coagulopathy of trauma shock early after trauma? An observational study
    Pär I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Crit Care 15:R272. 2011
    ..This study investigated the prevalence of overt DIC and ACoTS in trauma patients and characterized these conditions based on their biomarker profiles...
  14. ncbi The rare coagulation disorders--review with guidelines for management from the United Kingdom Haemophilia Centre Doctors' Organisation
    P H B Bolton-Maggs
    Department of Clinical Haematology, Manchester Royal Infirmary, Manchester, UK
    Haemophilia 10:593-628. 2004
    ..We have chosen to include a section on Ehlers-Danlos Syndrome because haematologists may be consulted about bleeding manifestations in such patients...
  15. pmc Functional definition and characterization of acute traumatic coagulopathy
    Ross Davenport
    Trauma Sciences, Blizard Institute of Cell and Molecular Science, Bart s and The London School of Medicine and Dentistry, Queen Mary University of London, UK
    Crit Care Med 39:2652-8. 2011
    ..To identify an appropriate diagnostic tool for the early diagnosis of acute traumatic coagulopathy and validate this modality through prediction of transfusion requirements in trauma hemorrhage...
  16. ncbi Can RapidTEG accelerate the search for coagulopathies in the patient with multiple injuries?
    Victor Jeger
    Emergency Department, University Hospital Berne, Inselspital, Switzerland
    J Trauma 66:1253-7. 2009
    ..RapidTEG is the most rapid available test for providing reliable information on coagulopathy in patients with multiple injuries. This has implications for improving patient care...
  17. ncbi Acute coagulopathy in isolated blunt traumatic brain injury
    Arasch Wafaisade
    Department of Trauma and Orthopedic Surgery, University of Witten Herdecke, Cologne Merheim Medical Center, Ostmerheimerstr 200, 51109 Cologne, Germany
    Neurocrit Care 12:211-9. 2010
    ..This study was conducted to assess the frequency, outcome, and risk factors associated with this complication...
  18. ncbi Red-blood-cell to plasma ratios transfused during massive transfusion are associated with mortality in severe multiple injury: a retrospective analysis from the Trauma Registry of the Deutsche Gesellschaft für Unfallchirurgie
    M Maegele
    Department of Trauma and Orthopedic Surgery, and Institute for Research in Operative Medicine IFOM, University of Witten Herdecke, Cologne Merheim Medical Center CMMC, Cologne, Germany
    Vox Sang 95:112-9. 2008
    ..To test whether an acute transfusion practice of packed red blood cells (pRBC) : fresh-frozen plasma (FFP) 1 : 1 would be associated with reduced mortality in acute bleeding multiply injury...
  19. ncbi Coagulation disorders after traumatic brain injury
    B S Harhangi
    Department of Neurosurgery, Erasmus MC, Rotterdam, The Netherlands
    Acta Neurochir (Wien) 150:165-75; discussion 175. 2008
    ..We aimed to review the current knowledge on the pathophysiology, incidence, nature, prognosis and treatment of coagulation disorders following traumatic brain injury (TBI)...
  20. ncbi Traumatic coagulopathy: the effect of brain injury
    Casey H Halpern
    Department of Neurosurgery, Hospital of the University of Pennsylvania, 3400 Spruce Street, Third Floor, Silverstein Pavilion, Philadelphia, PA 19104, USA
    J Neurotrauma 25:997-1001. 2008
    ..Peripheral hematologic studies may not reflect persistent coagulopathy in cerebral circulation...
  21. ncbi Early evaluation of acute traumatic coagulopathy by thrombelastography
    Roger C Carroll
    Department of Anesthesiology, University of Tennessee Graduate School of Medicine, Knoxville, Tenn 37920, USA
    Transl Res 154:34-9. 2009
    ..These coagulopathies were already evident OS. The TEG assays can assess coagulopathy, platelet dysfunction, and hyperfibrinolysis at an early stage posttrauma and suggest more effective interventions...
  22. ncbi Thrombelastography
    Hakon Reikvam
    Institute of Internal Medicine, Haukeland University Hospital, 5021 Bergen, Norway
    Transfus Apher Sci 40:119-23. 2009
    ..In the past decades there has been an increasing interest for TEG in clinical practice. In this paper we present the rationale for the method and a discussion of the possible application of TEG...
  23. ncbi Subsequent development of thrombocytopenia and coagulopathy in moderate and severe head injury: support for serial laboratory examination
    Matthew M Carrick
    Michel E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA
    J Trauma 58:725-9; discussion 729-30. 2005
    ..This study assessed the development of thrombocytopenia and coagulopathy at admission and within the subsequent 72 hours after TBI...
  24. ncbi Calibrated automated thrombin generation measurement in clotting plasma
    H Coenraad Hemker
    Synapse BV, Cardiovascular Research Institute, University of Maastricht, Maastricht, The Netherlands
    Pathophysiol Haemost Thromb 33:4-15. 2003
    ....
  25. ncbi Link between coagulation abnormalities and microcirculatory dysfunction in critically ill patients
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Curr Opin Anaesthesiol 22:150-4. 2009
    ..The current review discusses the role of coagulation in microcirculatory abnormalities and whether anticoagulants may improve microvascular perfusion...
  26. ncbi Early coagulopathy predicts mortality in trauma
    Jana B A MacLeod
    Jackson Memorial Hospital and Department of Surgery, University of Miami School of Medicine, Miami, Florida 33101, USA
    J Trauma 55:39-44. 2003
    ..Our objective was to measure the predictive value of the initial coagulopathy profile for trauma-related mortality...
  27. ncbi Postinjury coagulopathy management: goal directed resuscitation via POC thrombelastography
    Jeffry L Kashuk
    Department of Surgery, Denver Health Medical Center, University of Colorado Denver, CO, USA
    Ann Surg 251:604-14. 2010
    ....
  28. ncbi Warfarin-reversal: results of a phase III study with pasteurised, nanofiltrated prothrombin complex concentrate
    Ingrid Pabinger-Fasching
    Haematology and Haemostaseology Division, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria
    Thromb Res 122:S19-22. 2008
    ..In conclusion, Beriplex P/N is an effective and well-tolerated therapy for rapid, complete and predictable reversal of anticoagulation in patients with acute bleeding or requiring emergency surgery...
  29. ncbi Coagulation management in multiple trauma: a systematic review
    Heiko Lier
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Cologne, Cologne, Germany
    Intensive Care Med 37:572-82. 2011
    ..The management of trauma patients suffering from active bleeding has improved with a better understanding of trauma-induced coagulopathy. The aim of this manuscript is to give recommendations for coagulation management...
  30. ncbi Time course of coagulopathy in isolated severe traumatic brain injury
    Thomas Lustenberger
    Department of Surgery, Division of Acute Care Surgery Trauma, Emergency Surgery and Surgical Critical Care at the Los Angeles County University of Southern California MedicalCenter, Los Angeles, CA, United States
    Injury 41:924-8. 2010
    ..Thus, the aim of this study was to evaluate the time course of coagulopathy following isolated sTBI and its relationship to in-hospital outcomes...
  31. ncbi Viscoelastic clot strength predicts coagulation-related mortality within 15 minutes
    Michael Pezold
    Department of Surgery, University of Colorado at Denver, Denver, CO, USA
    Surgery 151:48-54. 2012
    ..We hypothesized that clot strength (G) measured by point-of-care rapid thrombelastography (r-TEG) on arrival in the emergency department can predict massive transfusion (MT) and coagulation-related mortality (MT-death)...
  32. ncbi Disorders of coagulation in stroke
    Salina P Waddy
    Neurology, Emory University, Atlanta, GA 30322, USA
    Semin Neurol 26:57-64. 2006
    ....
  33. ncbi Damage control resuscitation: a sensible approach to the exsanguinating surgical patient
    Alec C Beekley
    Madigan Army Medical Center, Tacoma, WA, USA
    Crit Care Med 36:S267-74. 2008
    ..These casualties suffer wounds that have no common civilian equivalent and more frequently require massive transfusion (greater than 10 units of packed red blood cells [PRBCs] in less than 24 hrs) than civilian injured...
  34. ncbi Fast interpretation of thromboelastometry in non-cardiac surgery: reliability in patients with hypo-, normo-, and hypercoagulability
    K Görlinger
    Klinik für Anästhesiologie und Intensivmedizin, Universitatsklinikum Essen, Universitat Duisburg Essen, Hufelandstrase 55, D 45122 Essen, Germany
    Br J Anaesth 110:222-30. 2013
    ..However, the reliability of early ROTEM(®) variables to predict maximum clot firmness (MCF) in non-cardiac surgery patients with subnormal, normal, and supranormal MCF has not yet been evaluated...
  35. ncbi Noninfectious serious hazards of transfusion
    Jeanne E Hendrickson
    Department of Pathology and Laboratory Medicine, Center for Transfusion and Cellular Therapies, Emory University School of Medicine, 1364 Clifton Rd, NE, Atlanta, GA 30322, USA
    Anesth Analg 108:759-69. 2009
    ..In this article, we review NISHOTs, focusing on the most recent concerns and literature...
  36. ncbi Hyperfibrinolysis at admission is an uncommon but highly lethal event associated with shock and prehospital fluid administration
    Bryan A Cotton
    Department of Surgery, The University of Texas Health Science Center, Houston, Texas 77030, USA
    J Trauma Acute Care Surg 73:365-70; discussion 370. 2012
    ..To further strengthen this hypothesis, we created an in vitro hemodilution model to improve our mechanistic understanding of the early HF...
  37. ncbi The role of rotational thromboelastometry in real time assessment of haemostasis in surgical settings
    Dragica Vucelic
    Institute of Digestive System Diseases, Clinical Centre of Serbia, Belgrade, Serbia
    Srp Arh Celok Lek 138:43-9. 2010
    ..We describe the value of ROTEM in two haemostatically compromised patients...
  38. pmc Reduced clot strength upon admission, evaluated by thrombelastography (TEG), in trauma patients is independently associated with increased 30-day mortality
    Kristin B Nystrup
    Department of Clinical Immunology, Section for Transfusion Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Scand J Trauma Resusc Emerg Med 19:52. 2011
    ..Thrombelastographic (TEG) clot strength has previously been shown to predict outcome in critically ill patients. The aim of the present study was to investigate this relation in the trauma setting...
  39. ncbi Acute coagulopathy of trauma: mechanism, identification and effect
    Karim Brohi
    Department of Surgery, The Royal London Hospital, London, UK
    Curr Opin Crit Care 13:680-5. 2007
    ..Developing early in the postinjury phase, it is associated with increased transfusion requirements and poor outcomes. This review examines the possible initiators, mechanism and clinical importance of acute coagulopathy...
  40. ncbi Diagnostic performance and therapeutic consequence of thromboelastometry activated by kaolin versus a panel of specific reagents
    Ole Halfdan Larsen
    Centre for Haemophilia and Thrombosis, Aarhus University Hospital, Skejby, Denmark
    Anesthesiology 115:294-302. 2011
    ....
  41. pmc Functional fibrinogen assay indicates that fibrinogen is critical in correcting abnormal clot strength following trauma
    Jeffrey N Harr
    Department of Surgery, University of Colorado Denver, Aurora, CO, USA
    Shock 39:45-9. 2013
    ..These data suggest that fibrinogen should be addressed early in trauma patients manifesting acute coagulopathy of trauma...
  42. pmc Early platelet dysfunction: an unrecognized role in the acute coagulopathy of trauma
    Max V Wohlauer
    Department of Surgery, University of Colorado Denver, Denver, CO, USA
    J Am Coll Surg 214:739-46. 2012
    ..Although the current debate on acute traumatic coagulopathy has focused on the consumption or inhibition of coagulation factors, the question of early platelet dysfunction in this setting remains unclear...
  43. ncbi Emerging treatment strategies for trauma-induced coagulopathy
    B Sorensen
    Centre for Haemostasis and Thrombosis, Guy s and St Thomas NHS Foundation Trust, St Thomas Hospital, London, UK
    Br J Surg 99:40-50. 2012
    ..Coagulopathy is related to blood loss including consumption of clotting factors and platelets and haemodilution. Additionally hyperfibrinolysis, hypothermia, acidosis and metabolic changes affect the coagulation system...
  44. ncbi Abnormal coagulation tests are associated with progression of traumatic intracranial hemorrhage
    Christopher B Allard
    Department of Surgery and or Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    J Trauma 67:959-67. 2009
    ..ICH commonly increases in size and coagulopathy has been implicated in such progression. We investigated the association between coagulopathy diagnosed by routine laboratory tests and ICH progression...
  45. ncbi Initial experiences with point-of-care rapid thrombelastography for management of life-threatening postinjury coagulopathy
    Jeffry L Kashuk
    Department of Surgery and Anesthesia, Denver Health Medical Center, Denver, Colorado, USA
    Transfusion 52:23-33. 2012
    ..We designed a prospective study to test the hypothesis that integrating TEG into our MTP would facilitate goal-directed therapy and provide equivalent outcomes compared to conventional coagulation testing...
  46. ncbi Splenectomy leads to a persistent hypercoagulable state after trauma
    Jennifer M Watters
    Department of Surgery, Division of Trauma, Critical Care and Acute Care Surgery, Oregon Health and Science University, Portland, OR, USA
    Am J Surg 199:646-51. 2010
    ..It was hypothesized that splenectomy following trauma results in hypercoagulability...
  47. ncbi Toward rational fresh frozen plasma transfusion: The effect of plasma transfusion on coagulation test results
    Lorne L Holland
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9072, USA
    Am J Clin Pathol 126:133-9. 2006
    ..7 showed a significant change in INR with FFP transfusion. Therefore, transfusion for patients not meeting current FFP guidelines does not reliably reduce the INR and exposes patients to unnecessary risk...
  48. ncbi Prothrombin complex concentrate reduces blood loss and enhances thrombin generation in a pig model with blunt liver injury under severe hypothermia
    Markus Honickel
    Department of Anaesthesiology, RWTH Aachen University Hospital, Aachen, Germany
    Thromb Haemost 106:724-33. 2011
    ..Furthermore, the impact and safety of PCC application can be monitored through thrombin generation and thromboelastometry under hypothermia...
  49. ncbi Acute traumatic coagulopathy
    Daniel Frith
    Trauma Sciences, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    Curr Opin Anaesthesiol 25:229-34. 2012
    ..This review delineates our current understanding of the clinical importance, aetiology and pathophysiology of acute traumatic coagulopathy (ATC)...
  50. ncbi Current trends in resuscitation strategy for the multiply injured patient
    Philip F Stahel
    Department of Orthopaedic Surgery, University of Colorado, Denver, Colorado 80204, USA
    Injury 40:S27-35. 2009
    ..This review article provides a brief overview of the existing resuscitation protocols for multiply injured patients, including ATLS and "damage control", and will address developing controversies in the field...
  51. ncbi Elevated plasma D-dimer and hypersensitive C-reactive protein levels may indicate aortic disorders
    Shi Min Yuan
    Department of Cardiothoracic Surgery, Afiliated Hospital, Taishan Medical College, Taian, Shandong Province, People s Republic of China
    Rev Bras Cir Cardiovasc 26:573-81. 2011
    ..However, the comparative study in these biomarkers between the patients with acute aortic dissection and coronary artery disease has not been sufficiently elucidated...
  52. ncbi Hyperfibrinolysis after major trauma: differential diagnosis of lysis patterns and prognostic value of thrombelastometry
    Herbert Schöchl
    Department of Anesthesiology and Intensive Care, AUVA Trauma Hospital, Salzburg, Austria
    J Trauma 67:125-31. 2009
    ..Furthermore, routine laboratory based and the rotational thrombelastometry analyzer (ROTEM)-derived variables were also correlated with survival...
  53. ncbi The natural history of trauma-related coagulopathy: implications for treatment
    Paul T Engels
    Department of Surgery, Sunnybrook Health Sciences Centre and University of Toronto, Toronto, Canada
    J Trauma 71:S448-55. 2011
    ..Our study sought to identify which trauma patients develop TAC and the factors associated with its development, to describe the natural history of TAC, and to identify patients with TAC who may not require hemostatic resuscitation...
  54. ncbi Blood coagulation disorders in septic patients
    Paul Knoebl
    Division of Hematology and Hemostasis, Department of Medicine I, Medical University of Vienna, Vienna, Austria
    Wien Med Wochenschr 160:129-38. 2010
    ..This article describes the major pathophysiologic reactions in these situations and presents www.SepDIC.eu, an online tool on sepsis and associated coagulopathy...
  55. ncbi Hypoperfusion in severely injured trauma patients is associated with reduced coagulation factor activity
    Jan O Jansen
    Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    J Trauma 71:S435-40. 2011
    ..This study was designed to examine the effect of hypoperfusion secondary to traumatic injury on the activity of coagulation factors...
  56. ncbi Recombinant factor VIIa for the correction of coagulopathy before emergent craniotomy in blunt trauma patients
    Carlos V R Brown
    Department of Surgery, University of Texas Southwestern Medical School Austin, University Medical Center Brackenridge Trauma Services, Austin, Texas 78701, USA
    J Trauma 68:348-52. 2010
    ..We hypothesize that rFVIIa would provide an effective and cost efficient means of correcting coagulopathy in patients with traumatic brain injury undergoing emergent craniotomy...
  57. ncbi Rapid thrombelastography delivers real-time results that predict transfusion within 1 hour of admission
    Bryan A Cotton
    Department of Surgery, The University of Texas Health Science Center, Houston, Texas 77030, USA
    J Trauma 71:407-14; discussion 414-7. 2011
    ..The purpose of this pilot study was to evaluate the timeliness of r-TEG results, their correlation with CCTs, and the ability of r-TEG to predict early blood transfusion...
  58. pmc Thrombelastography and biomarker profiles in acute coagulopathy of trauma: a prospective study
    Sisse R Ostrowski
    Section for Transfusion Medicine, Capital Region Blood Bank, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Scand J Trauma Resusc Emerg Med 19:64. 2011
    ..Severe injury induces an acute coagulopathy associated with increased mortality. This study compared the Thrombelastography (TEG) and biomarker profiles upon admission in trauma patients...
  59. ncbi Hepatic response to sepsis: interaction between coagulation and inflammatory processes
    J F Dhainaut
    Medical Intensive Care Unit, Cochin Port-Royal University-Hospital, AP-HP, Paris V University, France
    Crit Care Med 29:S42-7. 2001
    ..When this control is not adequate, a secondary hepatic dysfunction may occur and may sometimes lead to bacterial products spillover, enhanced procoagulant and inflammatory processes, and in turn, multiple organ failure and death...
  60. ncbi Pulmonary coagulopathy as a new target in therapeutic studies of acute lung injury or pneumonia--a review
    Marcus J Schultz
    Department of Intensive Care Medicine, University of Amsterdam, Netherlands, and the Interdepartmental Division of Critical Care, St Michael s Hospital, Toronto, ON, Canada
    Crit Care Med 34:871-7. 2006
    ..To review the involvement of coagulation and fibrinolysis in the pathogenesis of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), pulmonary infection, and ventilator-induced lung injury (VILI)...
  61. pmc Selective cellular expression of tissue factor in human tissues. Implications for disorders of hemostasis and thrombosis
    T A Drake
    Department of Pathology, UCLA
    Am J Pathol 134:1087-97. 1989
    ....
  62. ncbi Safety indicators for inpatient and outpatient oral anticoagulant care: [corrected] Recommendations from the British Committee for Standards in Haematology and National Patient Safety Agency
    T P Baglin
    British Committee for Standards in Haematology and National Patient Safety Agency
    Br J Haematol 136:26-9. 2007
  63. ncbi Coagulopathy in severe traumatic brain injury: a prospective study
    Peep Talving
    Department of Surgery, Division of Trauma and Critical Care at the Los Angeles County, University of Southern California Medical Center, Los Angeles, California 90033, USA
    J Trauma 66:55-61; discussion 61-2. 2009
    ..The incidence and risk factors for traumatic brain injury (TBI)-associated coagulopathy after severe TBI (sTBI) and the effect of this complication on outcomes have not been evaluated in any large prospective studies...
  64. pmc New insights into the coagulopathy of liver disease and liver transplantation
    M Senzolo
    Department of Surgical and Gastroenterological Sciences, University Hospital of Padua, Padua, Italy
    World J Gastroenterol 12:7725-36. 2006
    ..During liver transplantation haemorrage may occur due to the pre-existing hypocoagulable state, the collateral circulation caused by portal hypertension and increased fibrinolysis which occurs during this surgery...
  65. ncbi Fresh frozen plasma should be given earlier to patients requiring massive transfusion
    Ernest A Gonzalez
    Department of Surgery, University of Texas Houston Medical School, Houston, Texas, USA
    J Trauma 62:112-9. 2007
    ..The hypothesis for this study is that our pre-intensive care unit (ICU) massive transfusion (MT) protocol does not adequately correct coagulopathy, and that early uncorrected coagulopathy is predictive of mortality...
  66. ncbi Damage control hematology: the impact of a trauma exsanguination protocol on survival and blood product utilization
    Bryan A Cotton
    Departments of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Trauma 64:1177-82; discussion 1182-3. 2008
    ....
  67. ncbi Damage control resuscitation: directly addressing the early coagulopathy of trauma
    John B Holcomb
    USAISR, Fort Sam Houston, TX 78234 6315, USA
    J Trauma 62:307-10. 2007
  68. ncbi The coagulopathy of trauma versus disseminated intravascular coagulation
    John R Hess
    Department of Pathology, University of Maryland Medical Center, Baltimore, 21201, USA
    J Trauma 60:S12-9. 2006
    ..The coagulopathy of trauma should be anticipated in massive transfusion situations. Early treatment with plasma can delay its onset. The underlying mechanisms should be confirmed with laboratory testing...
  69. ncbi Efficacy and safety of recombinant factor VIIa for treatment of severe bleeding: a systematic review
    Marcel Levi
    Department of Vascular Medicine Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Crit Care Med 33:883-90. 2005
    ..Recombinant factor VIIa is, however, increasingly used for several other indications, including patients with a preexistent normal coagulation system but who experience serious bleeding, for example, after major surgery or trauma...
  70. ncbi Definition and drivers of acute traumatic coagulopathy: clinical and experimental investigations
    D Frith
    Trauma Clinical Academic Unit, The Royal London Hospital, Bart s and The London School of Medicine and Dentistry, Queen Mary University London, UK
    J Thromb Haemost 8:1919-25. 2010
    ..Acute traumatic coagulopathy (ATC) is an impairment of hemostasis that occurs early after injury and is associated with a 4-fold higher mortality, increased transfusion requirements and organ failure...
  71. ncbi Hemostatic abnormalities in patients with closed head injuries and their role in predicting early mortality
    Vineet Saggar
    Department of Neurosurgery, S M S Medical College, Jaipur, India
    J Neurotrauma 26:1665-8. 2009
    ..From this study we conclude that hemostatic abnormalities are independent predictors of early mortality in moderate-to-severe head injury patients...
  72. ncbi Coagulation defects in trauma patients: etiology, recognition, and therapy
    Thomas G Deloughery
    Division of Medical Oncology, L586 Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97201 3098, USA
    Crit Care Clin 20:13-24. 2004
    ..Attention also should be paid to any other correctable factors such as hypothermia. Finally, pre-existing disorders can influence the patient's hemostasis greatly and may require specific therapies...
  73. ncbi New insights into haemostasis in liver failure
    Ron Kerr
    Department of Haematology, Royal Infirmary of Edinburgh, Edinburgh, UK
    Blood Coagul Fibrinolysis 14:S43-5. 2003
    ..These findings have implications for appropriate coagulation factor support for patients with acute liver injury...
  74. ncbi Acute traumatic coagulopathy
    Karim Brohi
    Trauma and Critical Care Unit, Royal London Hospital, United Kingdom
    J Trauma 54:1127-30. 2003
    ..Traumatic coagulopathy is thought to be caused primarily by fluid administration and hypothermia...
  75. ncbi Investigation of risk factors in children with arterial ischemic stroke
    Vijeya Ganesan
    Neurosciences Unit, University College London, United Kingdom
    Ann Neurol 53:167-73. 2003
    ..Cerebral arterial imaging is usually abnormal, but echocardiography and prothrombotic screening are commonly negative...
  76. ncbi Clinical and cellular effects of hypothermia, acidosis and coagulopathy in major injury
    K Thorsen
    Department of Surgery, Stavanger University Hospital, Stavanger, Norway
    Br J Surg 98:894-907. 2011
    ..Hypothermia, acidosis and coagulopathy have long been considered critical combinations after severe injury. The aim of this review was to give a clinical update on this triad in severely injured patients...
  77. ncbi Complications of massive transfusion
    Kristen C Sihler
    University of Michigan School of Medicine, Ann Arbor, MI 48109 0033, USA
    Chest 137:209-20. 2010
    ..Once definitive control of hemorrhage has been established, a restrictive approach to blood transfusion should be implemented to minimize further complications...
  78. ncbi Damage control resuscitation: the need for specific blood products to treat the coagulopathy of trauma
    John R Hess
    Transfusion 46:685-6. 2006
  79. ncbi Effect of fresh-frozen plasma transfusion on prothrombin time and bleeding in patients with mild coagulation abnormalities
    Omar I Abdel-Wahab
    Department of Internal Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Transfusion 46:1279-85. 2006
    ....
  80. ncbi The coagulopathy of trauma: a review of mechanisms
    John R Hess
    Department of Pathology, University of Maryland Medical Center, Baltimore, Maryland 21201, USA
    J Trauma 65:748-54. 2008
    ..Coagulopathy associated with severe injury complicates the control of bleeding and is associated with increased morbidity and mortality in trauma patients. The causes and mechanisms are multiple and yet to be clearly defined...
  81. ncbi Coagulopathy in trauma patients: importance of thrombocyte function?
    Ross A Davenport
    Queen Mary University of London, Barts and the London School of Medicine and Dentistry London, UK
    Curr Opin Anaesthesiol 22:261-6. 2009
    ..This review examines our current knowledge of platelet function in haemostasis, possible mechanisms for aberrant activity in trauma and the role of platelet transfusions in exsanguinating haemorrhage...
  82. pmc Recombinant activated factor VII as an adjunctive therapy for bleeding control in severe trauma patients with coagulopathy: subgroup analysis from two randomized trials
    Sandro B Rizoli
    Department of Surgery and Critical Care Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, M4N 3M5 Canada
    Crit Care 10:R178. 2006
    ....
  83. ncbi Management of massive operative blood loss
    S Kozek-Langenecker
    Clinical Division B, Department of Anesthesiology and General Intensive Care Vienna Medical University, Vienna, Austria
    Minerva Anestesiol 73:401-15. 2007
    ..The present article reviews pathomechanisms of coagulopathy in massive bleeding, as well as routine laboratory tests and viscoelastic point-of-care hemostasis monitoring as the diagnostic basis for therapeutic interventions...
  84. ncbi Postinjury life threatening coagulopathy: is 1:1 fresh frozen plasma:packed red blood cells the answer?
    Jeffry L Kashuk
    Department of Surgery and Surgical Research, Denver Health Medical Center, Denver, Colorado 80204 4507, USA
    J Trauma 65:261-70; discussion 270-1. 2008
    ..Consequently, we reviewed our massive transfusion practices during a 5-year period to test the hypothesis that 1:1 FFP:RBC within the first 6 hours reduces life threatening coagulopathy...
  85. ncbi Early predictors of transfusion and mortality after injury: a review of the data-based literature
    Brian J Eastridge
    Department of Surgery, Division of Burn, Trauma, and Critical Care, University of Texas Southwestern Medical Center, Dallas, USA
    J Trauma 60:S20-5. 2006
  86. pmc Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway?
    Karim Brohi
    Department of Surgery, University of California at San Francisco, San Francisco, CA, USA
    Ann Surg 245:812-8. 2007
    ..We hypothesized that early coagulopathy is due to tissue hypoperfusion, and investigated derangements in coagulation associated with this...
  87. ncbi Early coagulopathy in multiple injury: an analysis from the German Trauma Registry on 8724 patients
    Marc Maegele
    Department of Trauma and Orthopedic Surgery, University of Witten Herdecke, Cologne Merheim Medical Center, Ostmerheimerstr 200, D 51109 Cologne, Germany
    Injury 38:298-304. 2007
    ..There is increasing evidence for acute traumatic coagulopathy occurring prior to emergency room (ER) admission but detailed information is lacking...
  88. pmc Pathophysiology of early trauma-induced coagulopathy: emerging evidence for hemodilution and coagulation factor depletion
    Beth H Shaz
    New York Blood Center, New York, New York 10065, USA
    J Trauma 70:1401-7. 2011
    ..Trauma patients present with a coagulopathy, termed early trauma-induced coagulopathy (ETIC), that is associated with increased mortality. This study investigated hemostatic changes responsible for ETIC...
  89. ncbi Diagnosis of early coagulation abnormalities in trauma patients by rotation thrombelastography
    L Rugeri
    Laboratory of Haemostasis, Edouard Herriot Hospital, Hospices Civils de Lyon and Claude Bernard University, Lyon, France
    J Thromb Haemost 5:289-95. 2007
    ..A hemostatic monitor capable of rapid and accurate detection of clinical coagulopathy within the resuscitation room could improve management of bleeding after trauma...
  90. ncbi Primary fibrinolysis is integral in the pathogenesis of the acute coagulopathy of trauma
    Jeffry L Kashuk
    Division of Trauma, Acute Care, and Critical Care Surgery, Department of Surgery, Penn State Hershey Medical Center, College of Medicine, Hershey, PA 17033, USA
    Ann Surg 252:434-42; discussion 443-4. 2010
    ..We hypothesized that postinjury PF occurs early in severe shock, leading to postinjury coagulopathy, and ultimately hemorrhage-related death...
  91. ncbi Early coagulopathy after isolated severe traumatic brain injury: relationship with hypoperfusion challenged
    Thomas Lustenberger
    Division of Acute Care Surgery Trauma, Emergency Surgery, and Surgical Critical Care at the Los Angeles County University of Southern California Medical Center, Los Angeles, California, USA
    J Trauma 69:1410-4. 2010
    ..The purpose of this study was to examine the incidence of tissue hypoperfusion in victims of severe traumatic brain injury (sTBI) and to determine the associations between hypoperfusion and TBI coagulopathy...
  92. ncbi Prothrombin complex concentrate (Beriplex P/N) for control of bleeding after kidney trauma in a rabbit dilutional coagulopathy model
    Ingo Pragst
    Department of Pharmacology and Toxicology, CSL Behring GmbH, Marburg, Germany
    Thromb Res 125:272-7. 2010
    ....
  93. ncbi Prothrombin complex concentrate versus recombinant factor VIIa for reversal of hemodilutional coagulopathy in a porcine trauma model
    Gerhard Dickneite
    Department of Pharmacology and Toxicology, CSL Behring GmbH, Marburg, Germany
    J Trauma 68:1151-7. 2010
    ..Multicomponent therapy with prothrombin complex concentrate (PCC) containing coagulation factors II, VII, IX, and X might offer potential advantages...
  94. pmc Increase in activated protein C mediates acute traumatic coagulopathy in mice
    Brian B Chesebro
    The Department of Surgery, University of California, San Francisco, California, USA
    Shock 32:659-65. 2009
    ..In addition, the cytoprotective effect of protein C activation seems to be necessary for survival of the initial shock injury...
  95. ncbi The in vitro effects of fibrinogen concentrate, factor XIII and fresh frozen plasma on impaired clot formation after 60% dilution
    Thorsten Haas
    Department of Anaesthesiology and Critical Care Medicine, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Anesth Analg 106:1360-5, table of contents. 2008
    ....
  96. ncbi Hemostatic changes after crystalloid or colloid fluid administration during major orthopedic surgery: the role of fibrinogen administration
    Markus Mittermayr
    Department of Anesthesiology and Critical Care Medicine, Innsbruck Medical University, Innsbruck, Austria
    Anesth Analg 105:905-17, table of contents. 2007
    ..To explore whether disturbed fibrin polymerization is the main problem underlying dilutional coagulopathy and can be reversed by fibrinogen administration, we conducted a prospective study using modified thrombelastography (ROTEM)...
  97. ncbi The association of coagulopathy and traumatic brain injury in patients with isolated head injury
    Shahriar Zehtabchi
    Department of Emergency Medicine, State University of New York, Downstate Medical Center, Brooklyn, NY 11203, United States
    Resuscitation 76:52-6. 2008
    ..The emergence of prothrombotic agents (e.g. activated factor VII) to treat traumatic brain injury (TBI) requires a better understanding of the association of coagulopathy with isolated head injury (IHI)...
  98. ncbi Time for changing coagulation management in trauma-related massive bleeding
    Dietmar Fries
    Department of General and Surgical Critical Care Medicine, Innsbruck Medical University, Austria
    Curr Opin Anaesthesiol 22:267-74. 2009
    ....
  99. doi Trauma and coagulopathy: a new paradigm to consider
    Jana B A MacLeod
    Department of Surgery, Emory University School of Medicine, 69 Jesse Hill Jr Ave, Suite 315, Atlanta, GA 30303, USA
    Arch Surg 143:797-801. 2008
  100. ncbi Postoperative bypass bleeding: a bypass-associated dilutional (BAD) coagulopathy?
    Brian S Bull
    School of Medicine, Department of Pathology and Human Anatomy, Loma Linda University, Loma Linda, CA 92350, USA
    Blood Cells Mol Dis 43:256-9. 2009
    ..The presence of un-neutralized protamine combined with critically lowered clotting factors leads to marked coagulopathy...
  101. ncbi Early coagulopathy after traumatic brain injury: the role of hypoperfusion and the protein C pathway
    Mitchell Jay Cohen
    Departments of Surgery, San Francisco General Hospital, University of California, San Francisco, USA
    J Trauma 63:1254-61; discussion 1261-2. 2007
    ..The objective of the present study was to determine the importance of hypoperfusion and protein C activation in causing early coagulopathy in TBI patients...

Research Grants60

  1. Methods for generalized ontology terms enrichment analysis
    Nigam Shah; Fiscal Year: 2013
    ..identified a class of diseases - blood coagulation disorders - that are associated with a significant depletion in substitutions a O-linked glycosylation sites...
  2. Role of Inter-alpha Inhibitors in Anthrax Intoxication
    Steven Opal; Fiscal Year: 2007
    ..Our research is focused on the development of a new and safe treatment based on the ability of inter-alpha proteins to prevent the fatal consequences of anthrax infection. [unreadable] [unreadable] [unreadable] [unreadable]..
  3. Bacteremia from Dental Extraction vs. Oral Hygiene
    Peter Lockhart; Fiscal Year: 2004
    ..Additionally, we will have unique and critical data for the development of both future research and evidence-based guidelines concerning antibiotic prophylaxis for individuals currently felt to be at risk for DSI. ..
  4. World Workshop in Oral Medicine IV
    Peter Lockhart; Fiscal Year: 2005
    ..The proceedings will be published as evidence-based recommendations for best clinical practice in Oral Medicine as well as providing suggestions for future basic science and clinical research. ..
  5. MOLECULAR BASIS OF CARDIAC-SPECIFIC HEMOSTASIS-COLLABORA
    WILLIAM AIRD; Fiscal Year: 2004
    ..Dr. Housman is an acknowledged expert in human genomics. Taken together, the individual projects and the collaborative efforts promise to provide important insight into the molecular basis of cardiac hemostasis. ..
  6. 2004 Endothelial Cell Phenotypes in Health & Disease
    WILLIAM AIRD; Fiscal Year: 2004
    ..This R13 application is a request for partial funding of the first GRC on Endothelial Cell Phenotypes in Health and Disease in 2004. ..
  7. Novel Approaches to Mend Deficient Glycosylation
    Hudson Freeze; Fiscal Year: 2005
    ....
  8. STRUCTURAL STUDIES OF BLOOD CLOTTING PROTEINS
    JOHN WEISEL; Fiscal Year: 2008
    ..abstract_text> ..
  9. PROSPECTIVE INVESTIGATION OF PULMONARY EMBOLISM DX-II
    Victor Tapson; Fiscal Year: 2003
    ..abstract_text> ..
  10. Endothelial Stem Cells in Tumor Vasculature
    PAMPEE YOUNG; Fiscal Year: 2005
    ..I hope that significant contributions to the study of stem cells will result in the establishment of a successful, independent research program. ..
  11. PRIMARY STRUCTURE OF PROTHROMBIN
    Kenneth Mann; Fiscal Year: 2008
    ..The major aim of this project is to elucidate the structure/function relationships of this material with respect to factor V inactivation and to access its potential significance in the pathology of human thrombosis. ..
  12. Rationally-Designed Synthetic Antithrombin Activators
    Umesh Desai; Fiscal Year: 2005
    ..The proposed work is critical for determining the organic activator to focus advanced phase II efforts. ..
  13. Basis of Post-Fontan Protein Losing Enteropathy
    Hudson Freeze; Fiscal Year: 2006
    ..The results could provide a fundamental understanding of how PLE develops, identify Fontan patients genetically at risk for developing PLE, and provide insights to new therapeutics for this enigmatic rare disease. ..
  14. SIGNAL TRANSDUCTION DEFECTS IN HUMAN PLATELETS
    A Rao; Fiscal Year: 2006
    ..Overall, our studies will provide new important insights into the regulation of two key platelet proteins (G-alpha-q and PLC-beta2) involved in platelet signaling and into the signaling mechanisms in platelets. ..
  15. BSSVE for Multi-Dimensional Blood Velocity Measurement
    CATERINA GALLIPPI; Fiscal Year: 2004
    ..2 million possible in the United States and $US32 million possible in the world-wide ultrasound market. ..
  16. Novel Carboxylated Glycans in Cell Adhesion
    Hudson Freeze; Fiscal Year: 2006
    ....
  17. MANNOSE IN MAMMALIAN GLYCOPROTEIN SYNTHESIS
    Hudson Freeze; Fiscal Year: 2001
    ..In some cases, mannose may be a therapeutic dietary supplement. A mannose supplementation trial for CDGS patients is now underway. ..
  18. MOLECULAR DEFECTS OF FIBRIN STABILIZATION
    Laszlo Lorand; Fiscal Year: 2002
    ..Detection of circulating factor XIIIa activity as an indicator of thrombotic tendency. 4. Fibronectin as the carrier of tissue transglutaminase in plasma. Practical and fundamental considerations. ..
  19. DEVELOPMENTAL CONTROL OF GNRH EXPRESSION BY POU PROTEINS
    Margaret Wierman; Fiscal Year: 2002
    ..Together these studies will define the physiological role and cellular mechanisms of POU protein control and GnRH gene expression. ..
  20. ADAMTS13 Deficiency in TTP
    Han Mou Tsai; Fiscal Year: 2008
    ..abstract_text> ..
  21. Modular Regulation of Genes within the Endothelium
    WILLIAM AIRD; Fiscal Year: 2003
    ..Together, these studies will provide new insights into the modular control of endothelial cell gene expression and in doing so facilitate the development of selective gene targeting strategies in cardiovascular disease. ..
  22. Symphony Multiplex Peptide Synthesizer w/ VISION Workstn
    Kenneth Mann; Fiscal Year: 2004
    ..There is currently no preparative HPLC system on the campus of the University of Vermont and this system is badly needed for many investigators. ..
  23. NOVEL FACTORS THAT REGULATE GNRH NEURONAL DEVELOPMENT
    Margaret E Wierman; Fiscal Year: 2010
    ....
  24. CELL MEDIATED HEMOSTASIS
    Harold Roberts; Fiscal Year: 2004
    ....
  25. NFkb Related Genetic Influences on Inflammation and Poor Health in Older Adults
    Jeremy Walston; Fiscal Year: 2009
    ..Clinically meaningful genotypes will highlight potential biologic pathways for interventions into a range of poor health outcomes in older adults. ..
  26. Control of menstrual bleeding disturbances in women
    Ian Fraser; Fiscal Year: 2006
    ..This study aims to explore these possibilities in large scale clinical studies, scientific study of vascular and molecular changes in endometrium and with the exploration of molecular mechanisms in mice. ..
  27. AIDS ASSOCIATED MALIGNANCIES CLINICAL TRIALS CONSORTIUM
    Alexandra Levine; Fiscal Year: 2005
    ..The expertise of our labs and experience will be available to the AMC, which will be considered of the highest priority for our Group. ..
  28. AIDS and Thrombocytopenia: Drug Abusers and Homosexuals
    Simon Karpatkin; Fiscal Year: 2009
    ....
  29. Procoagulants in Aging CARDIA Participants
    David Green; Fiscal Year: 2009
    ....
  30. Aberrant Platelet Mechanisms in Inherited Human Platelet Function Disorders
    ANGARA KONETI RAO; Fiscal Year: 2010
    ..Our studies will provide a wealth of information on platelet mechanisms and on potential new targets for antithrombotic therapy. ..
  31. Development of a Mouse Model for Frailty
    Jeremy Walston; Fiscal Year: 2008
    ..We expect to find that the frail mouse has higher levels of inflammatory markers, muscle weakness, and altered gene expression as it gets older, similar to what is found in frail, older humans. [unreadable] [unreadable] [unreadable]..
  32. Normobaric Hyperoxia in Acute Ischemic Stroke
    Aneesh B Singhal; Fiscal Year: 2010
    ..Breathing high-flow oxygen may prove to be a simple, practical, portable, and potentially cost-effective therapy that improves stroke outcomes, either independently or by extending the time window for IV tPA. ..
  33. Therapeutic Inhibitors of Phosphomannose Isomerase
    Hudson Freeze; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  34. Stabilized factor VIIIa as improved therapy for hemophilia A
    ANDREW GALE; Fiscal Year: 2008
    ..This treatment could improve the quality of life and overall health of the hemophilia A sufferers. ..
  35. PE BIOSYSTEMS VOYAGER DE MALDI-TOF
    Kenneth Mann; Fiscal Year: 2001
    ..The fulfillment of the specific aims described in detail in the twelve research proposals would be facilitated by the addiction of a Voyager-DE MALDI-TOF ..
  36. Human Glycosylation Disorders 2003
    Hudson Freeze; Fiscal Year: 2004
    ..Since this meeting immediately precedes the annual meeting of the Society for Glycobiology, it will increase the chances of recruiting glycobiologists to explore the various types of human glycosylation disorders. ..
  37. BARI II - FIBRINOLYSIS AND COAGULATION CORE
    Burton Sobel; Fiscal Year: 2006
    ..The investigators further expect that this collaborative effort will translate into a new practical clinical paradigm that will be used for treatment of Type II diabetic patients. ..
  38. Inflammation, Procoagulation, and Plaque Vulnerability
    Burton Sobel; Fiscal Year: 2005
    ..abstract_text> ..
  39. Inhibitors of ADAMTS313 and Outcome of TTP
    Han Mou Tsai; Fiscal Year: 2004
    ..abstract_text> ..
  40. Apoptosis in myelofibrosis with myeloid metaplasia
    Ruben Mesa; Fiscal Year: 2006
    ..abstract_text> ..
  41. Platelet Receptor Mediated Factor X Activation
    Peter Walsh; Fiscal Year: 2005
    ..We will determine the platelet agonists, receptors, signal transduction and effector mechanisms required for binding the components of the FX-activating complex. ..
  42. Lipoproteins, HIV, and Antiretroviral Therapy in SMART
    Daniel Duprez; Fiscal Year: 2008
    ..This proposal will produce additional information that will enhance their disease-free survival rate. (End of Abstract) [unreadable] [unreadable] [unreadable]..
  43. IMMUNOLOGY OF HUMAN PLATELETS (HIV-1-ITP)
    Simon Karpatkin; Fiscal Year: 2007
    ..4. Determine whether anti-GPIIla49-66 is a result of molecular mimicry with antigen of infectious origin or its products. ..
  44. Outcomes of Perinatal Stroke
    Meredith Golomb; Fiscal Year: 2008
    ..During the last year of the study, she plans to apply for an R01 grant to set up a pilot clinical trial. [unreadable] [unreadable]..
  45. Novel Carboxylated N-Glycans that Mediate Inflammation
    Hudson Freeze; Fiscal Year: 2003
    ..The impact of solving these structures could be quite substantial. However, in the past, we have had difficulty establishing this structure, and therein lies the risk in this project and why it responds to PA-97-049. ..
  46. Circle of Willis variability and migraine
    BRETT LEE CUCCHIARA; Fiscal Year: 2010
    ..If this hypothesis is confirmed, this could lead to new treatments based on a better understanding of migraine mechanisms and might help identify patients with migraine who are at risk of stroke. ..
  47. Proteomics and Biomarkers for Hepatocellular Cancer
    Nezam Afdhal; Fiscal Year: 2004
    ..These studies may lead to identification of more specific and sensitive biomarkers for HCC in HCV which can then be validated further in prospective clinical trials. ..
  48. Effect of Vitamin K on Age-Related Bone Loss
    Sarah Booth; Fiscal Year: 2005
    ..The proposed trial provides a unique opportunity to determine if supplemental vitamin K will reduce age-related bone loss in elderly men and women, above that achieved by supplemental calcium and vitamin D alone. ..
  49. Designing Mechanism-based Anticoagulants
    Umesh Desai; Fiscal Year: 2006
    ..abstract_text> ..
  50. EXPERIMENTAL THERAPY OF COLON CANCER WITH ANTISENSE FUTS
    Brent Weston; Fiscal Year: 2004
    ..The long-term goals are to extend the use of AS-ODNs to adjunctive treatment of colon carcinoma metastasis and to contribute to the study of glycosyltransferase gene regulation. ..
  51. Vitamin K: vascular calcification and age-related bone *
    Sarah Booth; Fiscal Year: 2004
    ..The proposed ancillary trial provides a unique opportunity to determine if vitamin K supplementation will reduce progression of vascular calcification in older men and women...
  52. Dietary & non-dietary components of vitamin K metabolism
    Sarah Booth; Fiscal Year: 2008
    ..The findings of the proposed study are critical for the interpretation of the epidemiologic and clinical data used to determine optimal intakes at which vitamin K may have a protective role in bone health. ..
  53. Induced hypothermic arrest in traumatic shock
    Hasan Alam; Fiscal Year: 2005
    ..Sub aim 2: Develop and test methods and techniques that can facilitate the induction of hypothermic arrest in the setting of traumatic shock. ..
  54. Hemorrhagic Shock and Pancreatic Enzyme Products
    David Hoyt; Fiscal Year: 2007
    ..The results of this research provide not only an approach to examine the different enzymatic and inflammatory processes in hemorrhagic shock but also to directly serve as the basis for possible intervention in patients. ..
  55. Immunity in Early Syphillis: Pathway to HIV Coinfection
    Juan Salazar; Fiscal Year: 2007
    ..In Aim 2 we will study the effect of secondary syphilis on viral load (VL) in HIV co-infected individuals. In this aim we will compare VL between HIV patients with and without syphilis and determine the effect of penicillin on VL. ..
  56. VITAMIN K INSUFFICIENCY--A RISK FACTOR FOR OSTEOPOROSIS
    Sarah Booth; Fiscal Year: 2001
    ..Results of the studies proposed could lead to effective intervention programs that reduce bone loss resulting in a decreased risk and incidence of osteoporosis. ..
  57. Antiviral Therapy in African Americans with HCV
    Nezam Afdhal; Fiscal Year: 2005
    ..Specimens of liver tissue and serum will be collected for basic studies on viral resistance. These studies should help determine the best therapy for AA with HCV. ..
  58. Biomarker Profiles in the Diagnosis/Prognosis of ARDS
    Lorraine Ware; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  59. Alveolar Epithelium in Acute Lung Injury
    Lorraine Ware; Fiscal Year: 2005
    ..Combined with a compelling research project, the training will -provide the skills necessary for a successful career in biomedical research. ..
  60. PROTEIN LIPID INTERACTIONS IN GALLSTONE PATHOGENESIS
    Nezam Afdhal; Fiscal Year: 2002
    ..These studies may lead to strategies for the prevention and non-surgical therapy of this very common disease. ..