hemolytic anemia

Summary

Summary: Anemia due to decreased life span of erythrocytes.

Top Publications

  1. pmc Both hemolytic anemia and malaria parasite-specific factors increase susceptibility to Nontyphoidal Salmonella enterica serovar typhimurium infection in mice
    Christelle M Roux
    Department of Medical Microbiology and Immunology, University of California at Davis, Davis, California 95616, USA
    Infect Immun 78:1520-7. 2010
  2. ncbi Primaquine-induced hemolytic anemia: susceptibility of normal versus glutathione-depleted rat erythrocytes to 5-hydroxyprimaquine
    Zachary S Bowman
    Department of Pharmacology, Medical University of South Carolina, 171 Ashley Avenue, Charleston, SC 29425, USA
    J Pharmacol Exp Ther 309:79-85. 2004
  3. doi Dapsone-induced hemolytic anemia in lung allograft recipients
    Priyumvada M Naik
    Division of Pulmonary, Allergy, and Critical Care Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    J Heart Lung Transplant 27:1198-202. 2008
  4. ncbi Relationship between anti-ABO antibody production and hemolytic anemia after minor ABO-mismatched living-donor lobar lung transplantation
    Y Sano
    Department of Cancer and Thoracic Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Transplant Proc 37:1371-2. 2005
  5. ncbi Cross-reactivity of cefotetan and ceftriaxone antibodies, associated with hemolytic anemia, with other: cephalosporins and penicillin
    Patricia A Arndt
    American Red Cross Blood Services, Southern California Region, Los Angeles 90006, USA
    Am J Clin Pathol 118:256-62. 2002
  6. doi Hemolytic anemia after operation for aortic dissection using teflon felt strips
    Yuki Nakamura
    Department of Cardiovascular Surgery, National Cardiovascular Center, Osaka, Japan
    Ann Thorac Surg 85:1784-7. 2008
  7. ncbi A surgical case for hemolytic anemia after ascending and total arch replacement
    Yasushige Shingu
    The Division of Thoracic Surgery, Department of Internal Medicine, Asahikawa City Hospital, Asahikawa, Japan
    Ann Thorac Cardiovasc Surg 11:416-8. 2005
  8. ncbi Association of naphthalene with acute hemolytic anemia
    K Santucci
    Department of Pediatrics and Emergency Medicine, Rhode Island Hospital Hasbro Children s Hospital, Providence, USA
    Acad Emerg Med 7:42-7. 2000
  9. ncbi Successful treatment of thrombocytopenia and hemolytic anemia with IvIG in a patient with lupus-like syndrome after mismatched related PBSCT
    A Hartert
    Clinic of Bone Marrow Transplantation and Haematology/Oncology, Idar-Oberstein Germany
    Bone Marrow Transplant 27:337-40. 2001
  10. ncbi Hemolytic anemia after methylene blue therapy for aniline-induced methemoglobinemia
    Yao Pan Liao
    Emergency Department, Taichung Veterans General Hospital, Taiwan
    Vet Hum Toxicol 44:19-21. 2002

Detail Information

Publications252 found, 100 shown here

  1. pmc Both hemolytic anemia and malaria parasite-specific factors increase susceptibility to Nontyphoidal Salmonella enterica serovar typhimurium infection in mice
    Christelle M Roux
    Department of Medical Microbiology and Immunology, University of California at Davis, Davis, California 95616, USA
    Infect Immun 78:1520-7. 2010
    ..early work suggests that an increased risk for developing systemic NTS infection during malaria is caused by hemolytic anemia, which leads to reduced macrophage microbicidal activity...
  2. ncbi Primaquine-induced hemolytic anemia: susceptibility of normal versus glutathione-depleted rat erythrocytes to 5-hydroxyprimaquine
    Zachary S Bowman
    Department of Pharmacology, Medical University of South Carolina, 171 Ashley Avenue, Charleston, SC 29425, USA
    J Pharmacol Exp Ther 309:79-85. 2004
    ..Methemoglobinemia and hemolytic anemia, however, are dose-limiting side effects of primaquine therapy...
  3. doi Dapsone-induced hemolytic anemia in lung allograft recipients
    Priyumvada M Naik
    Division of Pulmonary, Allergy, and Critical Care Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    J Heart Lung Transplant 27:1198-202. 2008
    ..We report a high prevalence of hemolytic anemia (HA) associated with dapsone use in LT patients when compared with other patients described in the literature ..
  4. ncbi Relationship between anti-ABO antibody production and hemolytic anemia after minor ABO-mismatched living-donor lobar lung transplantation
    Y Sano
    Department of Cancer and Thoracic Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Transplant Proc 37:1371-2. 2005
    ..5%) after transplantation, but only one of them showed evidence of severe hemolytic anemia due to donor-derived antibodies. The titer of that patient's Abs was higher than that of the other recipients...
  5. ncbi Cross-reactivity of cefotetan and ceftriaxone antibodies, associated with hemolytic anemia, with other: cephalosporins and penicillin
    Patricia A Arndt
    American Red Cross Blood Services, Southern California Region, Los Angeles 90006, USA
    Am J Clin Pathol 118:256-62. 2002
    ..There was very little cross-reactivity between cefotetan antibodies and the drugs tested in the present study. We have no data to determine whether the in vitro data relate to in vivo reactivity...
  6. doi Hemolytic anemia after operation for aortic dissection using teflon felt strips
    Yuki Nakamura
    Department of Cardiovascular Surgery, National Cardiovascular Center, Osaka, Japan
    Ann Thorac Surg 85:1784-7. 2008
    We report three cases of hemolytic anemia caused by anastomotic stenosis after surgical treatment for aortic dissection in which internal and external Teflon (DuPont, Wilmington, DE) felt strips were used for reinforcement of the aortic ..
  7. ncbi A surgical case for hemolytic anemia after ascending and total arch replacement
    Yasushige Shingu
    The Division of Thoracic Surgery, Department of Internal Medicine, Asahikawa City Hospital, Asahikawa, Japan
    Ann Thorac Cardiovasc Surg 11:416-8. 2005
    A 61-year-old man presented with consistent hemolytic anemia 15 months after ascending and total arch replacement for DeBakey I type acute aortic dissection...
  8. ncbi Association of naphthalene with acute hemolytic anemia
    K Santucci
    Department of Pediatrics and Emergency Medicine, Rhode Island Hospital Hasbro Children s Hospital, Providence, USA
    Acad Emerg Med 7:42-7. 2000
    ..To survey the rationale for naphthalene-containing moth repellent (mothball) use in the study population and to compare this with that of a more diverse population...
  9. ncbi Successful treatment of thrombocytopenia and hemolytic anemia with IvIG in a patient with lupus-like syndrome after mismatched related PBSCT
    A Hartert
    Clinic of Bone Marrow Transplantation and Haematology/Oncology, Idar-Oberstein Germany
    Bone Marrow Transplant 27:337-40. 2001
    ..The majority of cases reported on immune hemolytic anemia have been of alloimmune origin due to ABO red blood cell antigen incompatibilities between donor and ..
  10. ncbi Hemolytic anemia after methylene blue therapy for aniline-induced methemoglobinemia
    Yao Pan Liao
    Emergency Department, Taichung Veterans General Hospital, Taiwan
    Vet Hum Toxicol 44:19-21. 2002
    ..patient who suffered from aniline-induced methemoglobinemia with initial good response Heinz body but hemolytic anemia appeared later 3 d after methylene blue therapy. G6PD deficiency was identified...
  11. ncbi Primaquine-induced hemolytic anemia: effect of 6-methoxy-8-hydroxylaminoquinoline on rat erythrocyte sulfhydryl status, membrane lipids, cytoskeletal proteins, and morphology
    Laura J C Bolchoz
    Department of Pharmacology, Medical University of South Carolina, Charleston 29425, USA
    J Pharmacol Exp Ther 303:141-8. 2002
    ....
  12. ncbi Hemolytic anemia and benign pelvic tumors. A case report
    C L Buchwalter
    Department of Obstetrics and Gynecology, Aultman Hospital, 2600 Sixth Street, Canton, OH 44710, USA
    J Reprod Med 46:401-4. 2001
    BACKGROUND: Hemolytic anemia associated with benign pelvic neoplasms is very rare. Sixteen cases have been reported in the English-language literature. CASE: A 27-year-old woman complained of dizziness, fatigue and headache...
  13. ncbi Codon 104(-G), a dominant beta0-thalassemia-like phenotype in a German Caucasian family is associated with mild chronic hemolytic anemia but influenced in severity by co-inherited genetic factors
    Georgia Lahr
    Haematologica 92:1264-5. 2007
    ..A co-inherited a gene triplication, long-term transfusion therapy, and ineffective erythropoiesis were confounding factors...
  14. ncbi Biomarkers of polycyclic aromatic hydrocarbon (PAH)-associated hemolytic anemia in oiled wildlife
    Gera Troisi
    Environmental Monitoring Unit, School of Engineering and Design, Brunel University, Kingston Lane, Uxbridge, Middlesex UB8 3PH, UK
    Environ Res 105:324-9. 2007
    ..PAHs) in crude oil cause a range of adverse effects in oiled seabirds, one of the most common being hemolytic anemia via oxidative attack of erythrocytes by PAH metabolites resulting in hemoglobin leakage and formation of ..
  15. ncbi Cardiac hypertrophy in anion exchanger 1-null mutant mice with severe hemolytic anemia
    Bernardo V Alvarez
    Dept of Physiology, CIHR Membrane Protein Research Group, Univ of Alberta, Edmonton, Alberta, Canada
    Am J Physiol Heart Circ Physiol 292:H1301-12. 2007
    ..to assess the role of AE1 in heart function through study of AE1-null (AE1(-/-)) mice, which manifest severe hemolytic anemia resulting from erythrocyte fragility...
  16. ncbi Hemolytic anemia presenting with idiopathic intracranial hypertension
    Euthymia Vargiami
    First Department of Pediatrics, Aristotle University of Thessaloniki, Greece
    Pediatr Neurol 38:53-4. 2008
    We report on an 8-year-old girl with hemolytic anemia because of infection with parvovirus B19 and increased intracranial pressure. She presented acutely with headache, vomiting, and mild scleral and mucosal icterus...
  17. ncbi Microangiopathic hemolytic anemia in a patient with recurrent anal cancer and liver metastasis
    Kun Yun Yeh
    Division of Hemato Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei
    Chang Gung Med J 25:706-10. 2002
    Microangiopathic hemolytic anemia (MAHA) is a late but fatal complication in advanced cancers (cancer-associated). It may also appear in complete remission after chemotherapy (chemotherapy-related)...
  18. ncbi Acquired hemolytic anemia
    Asha Shah
    BSES MG Hospital and Holy Family Hospital, 6 32, Hari Kripa, S V Road, Santacruz W, Mumbai 400 054, India
    Indian J Med Sci 58:533-6. 2004
  19. ncbi [Hemolytic anemia disclosing Wilson's disease. Report of 2 cases]
    M Michel
    Service de Medecine Interne, Hopital Henri Mondor, 51, Avenue du Marechal de Lattre de Tassigny, 94010 Creteil, France
    Rev Med Interne 22:280-3. 2001
    The liver and central nervous system are the usual targets of Wilson's disease, an inherited disorder of copper metabolism. Severe hemolytic anemia is an unusual complication of Wilson's disease.
  20. ncbi Hemolytic anemia-associated pulmonary hypertension of sickle cell disease and the nitric oxide/arginine pathway
    Maria L Jison
    Am J Respir Crit Care Med 168:3-4. 2003
  21. ncbi Primaquine-induced hemolytic anemia: role of splenic macrophages in the fate of 5-hydroxyprimaquine-treated rat erythrocytes
    Zachary S Bowman
    Department of Cell and Molecular Pharmacology, Medical University of South Carolina, 173 Ashley Ave, Charleston, SC 29425, USA
    J Pharmacol Exp Ther 315:980-6. 2005
    Primaquine-induced hemolytic anemia is known to result from premature sequestration of damaged (but intact) erythrocytes by the spleen...
  22. ncbi Human adenylate kinase deficiency associated with hemolytic anemia. A single base substitution affecting solubility and catalytic activity of the cytosolic adenylate kinase
    S Matsuura
    Department of Biochemistry, Yamaguchi University School of Medicine, Ube, Japan
    J Biol Chem 264:10148-55. 1989
    Adenylate kinase deficiency in the erythrocyte is a rare genetic disorder associated with hemolytic anemia. To determine the molecular basis of this disorder, we first cloned the normal gene encoding human cytosolic adenylate kinase (AK1) ..
  23. ncbi Study of the molecular defects in glucose phosphate isomerase-deficient patients affected by chronic hemolytic anemia
    L Baronciani
    Division di Ematologia, I R C C S Ospedale Maggiore, Milano, Italy
    Blood 88:2306-10. 1996
    We have studied four unrelated Italian patients with chronic hemolytic anemia associated with glucose phosphate isomerase (GPI) deficiency...
  24. ncbi Adoptive immunotherapy to increase the level of donor hematopoietic chimerism after nonmyeloablative marrow transplantation for severe canine hereditary hemolytic anemia
    Alessandra Takatu
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Biol Blood Marrow Transplant 9:674-82. 2003
    Severe hemolytic anemia in Basenji dogs secondary to pyruvate kinase deficiency can be corrected by allogeneic hematopoietic cell transplantation (HCT) from littermates with normal hematopoiesis after conventional myeloablative or ..
  25. ncbi Severe hemolytic anemia and excessive leukocytosis masking mycoplasma pneumonia
    F Daxböck
    Department for Internal Medicine I, Division of Infectious Diseases and Chemotherapy, University Hospital of Vienna, Wahringer Gurtel 18 20, 1090 Wien, Austria
    Ann Hematol 80:180-2. 2001
    ..Nevertheless, severe hemolysis is exceptional. We report a case of life-threatening hemolytic anemia caused by M. pneumoniae...
  26. ncbi Hemolytic anemia after fludarabine therapy for chronic lymphocytic leukemia
    R B Weiss
    Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC, USA
    J Clin Oncol 16:1885-9. 1998
    A report of the clinical features, treatment, and outcome of patients who developed hemolytic anemia (HA) temporally associated with fludarabine (Fludara; Berlex Laboratories, Richmond, CA) therapy for chronic lymphocytic leukemia (CLL).
  27. ncbi Cyclophosphamide exerts no beneficial effect over prednisone alone in the initial treatment of acute immune-mediated hemolytic anemia in dogs: a randomized controlled clinical trial
    Nicola Mason
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 6010, USA
    J Vet Intern Med 17:206-12. 2003
    ..Cyclophosphamide is commonly used with prednisone in the initial treatment of severe idiopathic immune-mediated hemolytic anemia (IMHA) in dogs because retrospective reports suggest its benefit...
  28. ncbi A phosphoglycerate kinase mutant (PGK Herlev; D285V) in a Danish patient with isolated chronic hemolytic anemia: mechanism of mutation and structure-function relationships
    C Valentin
    Unité INSERM U 474, Hopital Henri Mondor, Creteil, France
    Hum Mutat 12:280-7. 1998
    ..Such an approach can be generalized to any other protein that has been crystallized and for which x-ray diffraction data are available in a species closely related to man...
  29. ncbi Carboxyhemoglobin elevation due to hemolytic anemia
    Neil B Hampson
    Center for Hyperbaric Medicine, Virginia Mason Medical Center, Seattle, Washington, USA
    J Emerg Med 33:17-9. 2007
    A critically ill man with drug-induced hemolytic anemia and hepatic failure was hospitalized at a private academic medical center in Seattle, Washington...
  30. ncbi Molecular defect of a phosphoglycerate kinase variant (PGK-Matsue) associated with hemolytic anemia: Leu----Pro substitution caused by T/A----C/G transition in exon 3
    M Maeda
    Department of Biochemical Genetics, Beckman Research Institute of the City of Hope, Duarte, CA 91010
    Blood 77:1348-52. 1991
    ..kinase variant (PGK-Matsue) associated with severe enzyme deficiency, congenital nonspherocytic hemolytic anemia, and mental disorders...
  31. pmc Use of cultured lymphoblastoid cells for the study of abnormal enzymes: molecular abnormality of a phosphoglycerate kinase variant associated with hemolytic anemia
    H Fujii
    Proc Natl Acad Sci U S A 78:2587-90. 1981
    ..7.2.3; X chromosome-linked) variant, PGKase-Tokyo, is associated with enzyme deficiency, nonspherocytic hemolytic anemia, and neurological disturbances...
  32. ncbi Cefotetan-induced hemolytic anemia causing severe hypophosphatemia
    S Mohammed
    Division of Gastroenterology, Brown University, School of Medicine, Providence, Rhode Island
    Am J Hematol 46:369-70. 1994
    ..A case of severe hypophosphatemia due to accelerated erythropoiesis in response to Cefotetan-induced hemolytic anemia is described...
  33. pmc Analysis of pyruvate kinase-deficiency mutations that produce nonspherocytic hemolytic anemia
    L Baronciani
    Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA 92037
    Proc Natl Acad Sci U S A 90:4324-7. 1993
    ..In normal subjects, five differences from the published cDNA sequence were documented...
  34. ncbi Hemolytic anemia
    Gurpreet Dhaliwal
    San Francisco Veterans Affairs Medical Center University of California San Francisco School of Medicine, San Francisco, California 94121, USA
    Am Fam Physician 69:2599-606. 2004
    ..The etiologies of hemolysis often are categorized as acquired or hereditary. Common acquired causes of hemolytic anemia are autoimmunity, microangiopathy, and infection...
  35. ncbi Cutaneous anthrax associated with microangiopathic hemolytic anemia and coagulopathy in a 7-month-old infant
    Abigail Freedman
    Department of Pediatrics, New York University Medical Center, 550 First Ave, New York, NY 10016, USA
    JAMA 287:869-74. 2002
    ..The infant displayed severe microangiopathic hemolytic anemia with renal involvement, coagulopathy, and hyponatremia...
  36. ncbi Hemolytic anemia due to warm autoantibodies
    Charles H Packman
    University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States
    Blood Rev 22:17-31. 2008
    The diagnosis of autoimmune hemolytic anemia (AHA) requires evidence of shortened red blood cell (RBC) survival mediated by autoantibodies directed against autologous RBCs...
  37. pmc Concurrent infections with vector-borne pathogens associated with fatal hemolytic anemia in a cattle herd in Switzerland
    Regina Hofmann-Lehmann
    Clinical Laboratory, University of Zurich, Switzerland
    J Clin Microbiol 42:3775-80. 2004
    ..We concluded that A. marginale was the major cause of the hemolytic anemia, while coinfections with other agents exacerbated the disease...
  38. ncbi T-antigen activation for prediction of pneumococcus-induced hemolytic uremic syndrome and hemolytic anemia
    Daniel Tsung Ning Huang
    Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan
    Pediatr Infect Dis J 25:608-10. 2006
    ..the most severe complications of invasive pneumococcal infection are hemolytic uremic syndrome (P-HUS) and hemolytic anemia (P-HA), which occur when the Thomsen-Freidenreich antigen (TA) is exposed on erythrocytes, platelets and ..
  39. ncbi Primaquine-induced hemolytic anemia: formation and hemotoxicity of the arylhydroxylamine metabolite 6-methoxy-8-hydroxylaminoquinoline
    L J Bolchoz
    Department of Pharmacology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Pharmacol Exp Ther 297:509-15. 2001
    ..However, methemoglobinemia and hemolytic anemia are dose-limiting side effects of primaquine therapy that limit its efficacy...
  40. ncbi The role of oxidative stress in hemolytic anemia
    Eitan Fibach
    Department of Hematology, Hadassah Hebrew University Medical Center, Ein Kerem, Jerusalem, Israel
    Curr Mol Med 8:609-19. 2008
    ..In this review we describe the role of oxidative stress and the potential therapeutic potential of anti-oxidants in various hemolytic anemias...
  41. ncbi Normoblastosis, a murine model for ankyrin-deficient hemolytic anemia, is caused by a hypomorphic mutation in the erythroid ankyrin gene Ank1
    Connie S Birkenmeier
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Hematol J 4:445-9. 2003
    ....
  42. ncbi Prognostic factors for mortality and thromboembolism in canine immune-mediated hemolytic anemia: a retrospective study of 72 dogs
    Anthony P Carr
    Small Animal Clinical Sciences, Western College of Veterinary Medicine, Saskatoon, SK, Canada
    J Vet Intern Med 16:504-9. 2002
    Medical records of 72 dogs diagnosed with immune-mediated hemolytic anemia (IMHA) were reviewed to find risk factors for the disease, for mortality, and for thromboembolism...
  43. ncbi Combined deletion of mouse dematin-headpiece and beta-adducin exerts a novel effect on the spectrin-actin junctions leading to erythrocyte fragility and hemolytic anemia
    Huiqing Chen
    Department of Pharmacology Cancer Center, University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    J Biol Chem 282:4124-35. 2007
    ..Peripheral blood analysis shows evidence of severe hemolytic anemia with reduced number of erythrocytes/hematocrit/hemoglobin and an approximately 12-fold increase in the number ..
  44. ncbi Rituximab for the treatment of refractory autoimmune hemolytic anemia in children
    Marco Zecca
    Oncoematologia Pediatrica, IRCCS Policlinico San Matteo, Pavia, Italy
    Blood 101:3857-61. 2003
    Autoimmune hemolytic anemia (AIHA) in children is sometimes characterized by a severe course, requiring prolonged administration of immunosuppressive therapy...
  45. ncbi Protein-4.2 association with band 3 (AE1, SLCA4) in Xenopus oocytes: effects of three natural protein-4.2 mutations associated with hemolytic anemia
    Ashley M Toye
    Department of Biochemistry, School of Medical Sciences, University of Bristol, BS8 1TD, United Kingdom
    Blood 105:4088-95. 2005
    ..2 based on the structure of the sequence-related protein transglutaminase. Using our results in oocytes and this homology model we speculate how these mutations affect protein 4.2 and result in hereditary spherocytosis...
  46. ncbi The prognostic significance of a positive direct antiglobulin test in chronic lymphocytic leukemia: a beneficial effect of the combination of fludarabine and cyclophosphamide on the incidence of hemolytic anemia
    Claire Dearden
    Royal Marsden National Health Service NHS Foundation Trust and Institute of Cancer Research, Sutton, Surrey, UK
    Blood 111:1820-6. 2008
    Autoimmune hemolytic anemia (AHA) is a common complication in chronic lymphocytic leukemia (CLL)...
  47. doi Heme induces endothelial tissue factor expression: potential role in hemostatic activation in patients with hemolytic anemia
    B N Y Setty
    Marian Anderson Comprehensive Sickle Cell Anemia Care and Research Center, Department of Pediatrics, Division of Research Hematology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Thromb Haemost 6:2202-9. 2008
    ..the possibility that heme, an inflammatory mediator and a product of intravascular hemolysis in patients with hemolytic anemia including sickle cell disease, could modulate hemostasis by an effect on endothelial tissue factor (TF) ..
  48. ncbi Future development of lymphoproliferative disorders in patients with autoimmune hemolytic anemia
    S Sallah
    Division of Hematology Oncology, University of Tennessee Health Science Center, Memphis, Tennessee 38103, USA
    Clin Cancer Res 7:791-4. 2001
    The association between autoimmune hemolytic anemia (AIHA) and subsequent appearance of lymphoproliferative disorders (LPDs) has not been properly addressed in large-scale studies...
  49. pmc Features associated with, and the impact of, hemolytic anemia in patients with systemic lupus erythematosus: LX, results from a multiethnic cohort
    Sergio Durán
    University of Alabama at Birmingham, AL, USA
    Arthritis Rheum 59:1332-40. 2008
    To examine the clinical and genetic correlates of hemolytic anemia and its impact on damage accrual and mortality in systemic lupus erythematosus (SLE) patients.
  50. ncbi Role of oxidant stress in lawsone-induced hemolytic anemia
    David C McMillan
    Department of Pharmacology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Toxicol Sci 82:647-55. 2004
    ..Application of henna can induce a severe hemolytic anemia, and lawsone is thought to be the causative agent...
  51. pmc GLUT1 mutations are a cause of paroxysmal exertion-induced dyskinesias and induce hemolytic anemia by a cation leak
    Yvonne G Weber
    Neurologische Klinik and Institut für Anatomie und Zellbiologie, Universitat Ulm, Ulm, Germany
    J Clin Invest 118:2157-68. 2008
    ..Their PED was accompanied by epilepsy, mild developmental delay, reduced CSF glucose levels, hemolytic anemia with echinocytosis, and altered erythrocyte ion concentrations...
  52. ncbi [Severe falciparum malaria with prolonged hemolytic anemia after successful treatment with intravenous artesunate]
    Ichiro Itoda
    Department of Infectious Diseases, Tokyo Women s Medical University
    Kansenshogaku Zasshi 76:600-3. 2002
    ..She developed hemolytic anemia and jaundice on day 11 and blood transfusion was required...
  53. ncbi Gamma-glutamylcysteine synthetase deficiency and hemolytic anemia
    E Beutler
    Department of Molecular and Experimental Medicine, Research Institute of Scripps Clinic, La Jolla, CA 92037
    Blood 75:271-3. 1990
    ..enzyme has been found only once previously in humans: it was associated with spinocerebellar degeneration and hemolytic anemia. We report the case of a woman, daughter of fifth cousins, who was gamma-glutamylcysteine-synthetase-..
  54. ncbi Cefotetan-induced hemolytic anemia after perioperative prophylaxis
    Monte E Martin
    Division of Hematology and Medical Oncology, University of Louisville, J G Brown Cancer Center, Kentucky 40202, USA
    Am J Hematol 81:186-8. 2006
    Cephalosporin-induced hemolytic anemia is an acquired form of hemolytic anemia caused by interaction of drug with the immune system. Drug adsorption, drug-dependent antibody, and autoimmune induction are the three mechanisms of hemolysis...
  55. ncbi Hemolytic anemia, thrombosis, and infarction in male and female F344 rats following gavage exposure to 2-butoxyethanol
    B I Ghanayem
    National Institutes of Health, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Exp Toxicol Pathol 53:97-105. 2001
    ..BE causes severe hemolytic anemia in male and female rats and mice...
  56. ncbi Downeast anemia (dea), a new mouse model of severe nonspherocytic hemolytic anemia caused by hexokinase (HK(1)) deficiency
    L L Peters
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Blood Cells Mol Dis 27:850-60. 2001
    A new spontaneous mutation in the A/J inbred mouse strain, downeast anemia (dea), causes severe hemolytic anemia with extensive tissue iron deposition and marked reticulocytosis. The anemia is present at birth and persists throughout life...
  57. ncbi Point mutations in the L-type pyruvate kinase gene of two children with hemolytic anemia caused by pyruvate kinase deficiency
    B Neubauer
    Universitäts Kinderklinik, Gottingen, Germany
    Blood 77:1871-5. 1991
    ..In contrast to PK Linz, this amino acid lies outside the deduced substrate binding site and kinetic parameters of PK Beirut are close to normal. Both enzyme variants show a markedly reduced specific activity and thermolability...
  58. ncbi Drug-induced immune hemolytic anemia
    Abdulgabar Salama
    Charite Universitatsmedizin Berlin, Institut fur Transfusionsmedizin, Augustenburger Platz 1, D 13353 Berlin, Germany
    Expert Opin Drug Saf 8:73-9. 2009
    Drug-induced immune hemolytic anemia is frequently associated with serious complications.
  59. pmc Diverse point mutations in the human glucose-6-phosphate dehydrogenase gene cause enzyme deficiency and mild or severe hemolytic anemia
    T J Vulliamy
    Department of Haematology, Royal Postgraduate Medical School, London, Great Britain
    Proc Natl Acad Sci U S A 85:5171-5. 1988
    ..In G6PD Santiago, a de novo mutation (glycine----arginine) is associated with severe chronic hemolytic anemia. The mutations observed show a striking predominance of C----T transitions, with CG doublets involved in four ..
  60. ncbi A missense mutation in the heavy subunit of gamma-glutamylcysteine synthetase gene causes hemolytic anemia
    E Ristoff
    Department of Pediatrics, Karolinska Institute, Huddinge University Hospital, Huddinge, Sweden
    Blood 95:2193-6. 2000
    ..Hereditary deficiency of GCS has been reported in 6 patients with hemolytic anemia and low erythrocyte levels of glutathione and gamma-glutamylcysteine...
  61. doi Evaluating treatment of hepatitis C for hemolytic anemia management
    Swati DebRoy
    Department of Mathematics, University of Florida, Gainesville, FL, USA
    Math Biosci 225:141-55. 2010
    ..The most common and life threatening among them is hemolytic anemia, necessitating dose reduction or therapy cessation...
  62. ncbi Metformin-induced hemolytic anemia in a patient with glucose-6- phosphate dehydrogenase deficiency
    Antopolsky Meir
    Diabetes Care 26:956-7. 2003
  63. ncbi Missense mutations in the human glutathione synthetase gene result in severe metabolic acidosis, 5-oxoprolinuria, hemolytic anemia and neurological dysfunction
    N Dahl
    Department of Clinical Genetics, Uppsala University Children s Hospital, Sweden
    Hum Mol Genet 6:1147-52. 1997
    ..Our results suggest that complete loss of function of both GS alleles is probably lethal. It is postulated that missense mutations will account for the phenotype in the majority of patients with severe GS deficiency...
  64. ncbi Microangiopathic hemolytic anemia (MAHA) as paraneoplastic syndrome in metastasized signet ring cell carcinomas: case reports and review of the literature
    H T Arkenau
    Klinik fur Innere Medizin, Klinikum Bremen Ost, Bremen, Germany
    Z Gastroenterol 43:719-22. 2005
    We report on two spontaneous cases of microangiopathic hemolytic anemia (MAHA) as first manifestation due to metastasized signet ring carcinoma, one of gastric and one of unknown origin...
  65. ncbi [Severe microangiopathic hemolytic anemia as first manifestation of a CUP syndrome. Rapid hematologic remission under polychemotherapy]
    Ahmed Abdel Samie
    Medizinische Klinik II, Städtisches Klinikum Pforzheim, Akademisches Lehrkrankenhaus der Universität Heidelberg, Pforzheim
    Med Klin (Munich) 99:148-53. 2004
    Microangiopathic hemolytic anemia (MAHA) represents a rare manifestation of malignant tumors...
  66. doi Hemolytic anemia with aortic stenosis resolved by urgent aortic valve replacement
    Isamu Kawase
    Department of Cardiovascular Surgery, Mie Heart Center, Taki gun, Mie, Japan
    Ann Thorac Surg 86:645-6. 2008
    ..All laboratory data returned to normal physiological values. In conclusion, the observed hemolysis was related to the aortic shear stress of a calcified aortic valve...
  67. ncbi Role of metabolites in propanil-induced hemolytic anemia
    D C McMillan
    Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston 29425
    Toxicol Appl Pharmacol 110:70-8. 1991
    b>Hemolytic anemia and methemoglobinemia induced by exposure to certain arylamines, such as aniline and dapsone, are known to be mediated by their N-hydroxylamine metabolites...
  68. ncbi Severe hemolytic anemia due to passenger lymphocytes after living-related bowel transplant
    F Panaro
    Department of Surgery, Transplant Division, University of Illinois at Chicago, Chicago, IL, USA
    Clin Transplant 18:332-5. 2004
    b>Hemolytic anemia following solid organ transplant may be caused by 'passenger' lymphocytes producing antibodies against erythrocytes. This phenomenon has never been described after intestinal transplant.
  69. ncbi Acute viral hepatitis A and parvovirus B19 infections complicated by pure red cell aplasia and autoimmune hemolytic anemia
    Aref Chehal
    J Hepatol 37:163-5. 2002
  70. ncbi Homozygous intragenic deletion of type I hexokinase gene causes lethal hemolytic anemia of the affected fetus
    Hitoshi Kanno
    Blood 100:1930. 2002
  71. ncbi [Characteristics of autoimmune hemolytic anemia in adults: retrospective analysis of 83 cases]
    I Genty
    Service de Medecine Interne, Hopital Henri Mondor, 51, Avenue du Marechal de Lattre de Tassigny, 94010 Creteil, France
    Rev Med Interne 23:901-9. 2002
    ..To describe the main characteristics and outcome of adult's acquired immune hemolytic anemias (AIHA). To analyse the relevance of the complementary tests performed for the search of an underlying disease...
  72. ncbi The changing spectrum of drug-induced immune hemolytic anemia
    Patricia A Arndt
    American Red Cross Blood Services, Pomona, CA 91768, USA
    Semin Hematol 42:137-44. 2005
    Drug-induced immune hemolytic anemia (DIIHA) occurs rarely. To date, about 100 drugs have been implicated in causing DIIHA and/or a positive direct antiglobulin test (DAT)...
  73. ncbi A deletional frameshift mutation in protein 4.2 gene (allele 4.2 Lisboa) associated with hereditary hemolytic anemia
    S Hayette
    CNRS URA 1171, Institut Pasteur de Lyon, France
    Blood 85:250-6. 1995
    We studied a 26-year-old Portuguese patient with recessively transmitted hereditary hemolytic anemia. Protein 4.2 was absent from red cell ghosts by Western blotting. Although the 4...
  74. ncbi Conditional deletion of the Bcl-x gene from erythroid cells results in hemolytic anemia and profound splenomegaly
    K U Wagner
    Laboratory of Genetics and Physiology, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bldg 8, Rm 107, Bethesda, MD 20892 0822, USA
    Development 127:4949-58. 2000
    ..Three-month-old animals suffered from severe hemolytic anemia, hyperplasia of immature erythroid cells and profound enlargement of the spleen...
  75. ncbi Microangiopathic hemolytic anemia as an initial presentation of metastatic cancer of unknown primary origin
    Y C Lin
    Department of Internal Medicine, Chang Gung Medical College, Chang Gung Memorial Hospital, Taipei, Taiwan, ROC
    South Med J 88:683-7. 1995
    Microangiopathic hemolytic anemia (MAHA) is a well-documented but rare complication of disseminated cancer; it usually occurs in the late or terminal stage of cancer...
  76. ncbi Cytotoxic antibodies trigger inflammation through Fc receptors
    R Clynes
    Program in Molecular Biology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Immunity 3:21-6. 1995
    ..cytotoxic and immune complex-triggered inflammatory disorders, typified by rheumatic diseases, autoimmune hemolytic anemia, and thrombocytopenia...
  77. ncbi Molecular analysis of glucose phosphate isomerase deficiency associated with hereditary hemolytic anemia
    H Kanno
    Okinaka Memorial Institute for Medical Research, Tokyo, Japan
    Blood 88:2321-5. 1996
    We report here two new cases of glucose phosphate isomerase (GPI) deficiency associated with hemolytic anemia and present the results of molecular analysis of the five Japanese GPI variants...
  78. pmc A novel G6PD mutation leading to chronic hemolytic anemia
    Jenny McDade
    Department of Hematology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Pediatr Blood Cancer 51:816-9. 2008
    Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an important cause of hemolytic anemia worldwide. Severely affected patients have chronic hemolysis with exacerbations following oxidative stress...
  79. ncbi Primaquine-induced hemolytic anemia: role of membrane lipid peroxidation and cytoskeletal protein alterations in the hemotoxicity of 5-hydroxyprimaquine
    Zachary S Bowman
    Dept of Cell and Molecular Pharmacology, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    J Pharmacol Exp Ther 314:838-45. 2005
    Primaquine-induced hemolytic anemia is a toxic side effect that is due to premature splenic sequestration of intact erythrocytes...
  80. pmc Identification, molecular characterization, and experimental transmission of a new hemoplasma isolate from a cat with hemolytic anemia in Switzerland
    Barbara Willi
    Clinical Laboratory, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057 Zurich, Switzerland
    J Clin Microbiol 43:2581-5. 2005
    ..feline hemoplasma isolate in a blood sample collected from a cat that had exhibited clinical signs of severe hemolytic anemia. This agent was readily transmitted via intravenous inoculation to two specific-pathogen-free cats...
  81. ncbi Successful rituximab therapy for hemolytic anemia associated with relapsed splenic marginal zone lymphoma with leukemic phase
    Semra Paydas
    Leuk Lymphoma 44:2165-6. 2003
  82. ncbi Severe microangiopathic hemolytic anemia and thrombocytopenia in a child with Brucella infection
    A Yaramis
    Dicle University Faculty of Medicine, Department of Pediatrics, Diyarbakir, Turkey
    Ann Hematol 80:546-8. 2001
    We present a case of severe microangiopathic hemolytic anemia and thrombocytopenia with epistaxis, gross hematuria, hemoglobinuria, and skin purpura in a child with Brucella septicemia proven by culture...
  83. ncbi Prevention of garlic-induced hemolytic anemia using some tropical green leafy vegetables
    Ganiyu Oboh
    Biochemistry Department, Federal University of Technology, Akure, Nigeria
    J Med Food 7:498-501. 2004
    ..However, excessive intake of garlic may cause hemolytic anemia. This project sought to investigate the ability of some commonly consumed tropical green leafy vegetables-..
  84. ncbi Heinz body hemolytic anemia with eccentrocytosis from ingestion of Chinese chive (Allium tuberosum) and garlic (Allium sativum) in a dog
    Osamu Yamato
    Laboratory of Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita ku, Sapporo, Japan
    J Am Anim Hosp Assoc 41:68-73. 2005
    ..Hematological examinations revealed severe Heinz body hemolytic anemia with eccentrocytosis and an increased concentration of methemoglobin, which was thought to result from ..
  85. ncbi Deficiency of the mouse complement regulatory protein mCd59b results in spontaneous hemolytic anemia with platelet activation and progressive male infertility
    Xuebin Qin
    Department of Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Immunity 18:217-27. 2003
    ..Consistently, mCd59b knockout mice present a strong phenotype characterized by hemolytic anemia with increased reticulocytes, anisopoikilocytosis, echinocytosis, schistocytosis, free hemoglobin in plasma, ..
  86. ncbi Mycoplasma pneumoniae infection associated with hemolytic anemia--report of one case
    Jinn Li Wang
    Department of Pediatrics, Taipei Medical University, Wan Fang Hospital, Taipei, Taiwan
    Acta Paediatr Taiwan 45:293-5. 2004
    Immune hemolytic anemia is a rare condition in childhood. Cold agglutinins have been implicated in the etiology of the hemolysis...
  87. ncbi Hydroxyurea-induced hemolytic anemia in a patient with essential thrombocythemia
    Fadi I Jabr
    Internal Medicine, Peace Harbor Hospital, PeaceHealth Associates, Florence, Oregon, USA
    Am J Hematol 77:374-6. 2004
    ..Herein we report a case of an 80-year-old man with ET who developed severe hemolytic anemia requiring multiple packed RBC transfusions while being treated with HU...
  88. ncbi A toxicogenomic approach revealed hepatic gene expression changes mechanistically linked to drug-induced hemolytic anemia
    Masatomo Rokushima
    Discovery Technologies 1, Discovery Research Laboratories, Shionogi and Co Ltd, 12 4, Sagisu 5 Chome, Fukushima ku, Osaka 553 0002, Japan
    Toxicol Sci 95:474-84. 2007
    A variety of pharmaceutical compounds causes hemolytic anemia as a significant adverse effect and this toxicity restricts the clinical utility of these drugs...
  89. ncbi Induction of reversible hemolytic anemia in living zebrafish using a novel small molecule
    Ebrahim Shafizadeh
    Department of Molecular, Cell, and Developmental Biology, University of California at Los Angeles, 621 Charles E Young Drive, South Life Sciences Building, LS4325, Los Angeles, CA 90095, USA
    Comp Biochem Physiol C Toxicol Pharmacol 138:245-9. 2004
    ..Here, we present the characterization of hemolytic anemia induced in zebrafish by the small molecule 5115318 (3-[5-methyl-furan 2-yl]-propionic acid N'-phenyl-..
  90. ncbi Kala-azar associated with coombs-positive autoimmune hemolytic anemia in the patients coming from the endemic area of this disease and successful treatment of these patients with liposomal amphotericin B
    Erol Erduran
    Karadeniz Technical University, School of Medicine, Department of Pediatrics, Trabzon, Turkey
    Pediatr Hematol Oncol 22:349-55. 2005
    ..Although anemia is a usual finding, Coombs-positive autoimmune hemolytic anemia (AIHA) has rarely been reported with this disease...
  91. ncbi Hepatitis E virus infection with nonimmune hemolytic anemia
    Veena Zamvar
    Department of Paediatric Gastroenterology and Hepatology, St James s University Hospital, Leeds LS9 7TF, UK
    J Pediatr Gastroenterol Nutr 40:223-5. 2005
  92. ncbi [Hypothyroidism, hemolytic anemia and cryoglobulinemia in a patient with hepatitis C virus infection: efficacy of treatment with alpha-interferon]
    A Castellano Higuera
    An Med Interna 20:391-2. 2003
  93. ncbi Intracaval and intracardiac metastatic nonseminomatous germ cell tumor: a rare cause of hemolytic anemia and thrombocytopenia
    Ari D Fishman
    Department of Medical Oncology, Montefiore Medical Center, 111 E 210th Street, Hofheimer 1, Albert Einstein College of Medicine, Bronx, NY 10467, USA
    Cancer Invest 20:996-1001. 2002
    ..Resection of the intracardiac mass, prompted by rapid tumor progression despite treatment with systemic chemotherapy, demonstrated mature teratoma and resulted in prompt normalization of the patients hematologic profile...
  94. ncbi Primaquine-induced hemolytic anemia: formation of free radicals in rat erythrocytes exposed to 6-methoxy-8-hydroxylaminoquinoline
    Laura J C Bolchoz
    Department of Pharmacology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Pharmacol Exp Ther 303:1121-9. 2002
    Primaquine is an important antimalarial drug that is often dose-limited in therapy by the onset of hemolytic anemia. We have shown recently that an N-hydroxy metabolite of primaquine, 6-methoxy-8-hydroxylaminoquinoline (MAQ-NOH), is a ..
  95. ncbi Transgenic rescue of hemolytic anemia due to red blood cell pyruvate kinase deficiency
    Hitoshi Kanno
    Department of Transfusion Medicine and Cell Processing, Tokyo Women s Medical University, Tokyo, Japan
    Haematologica 92:731-7. 2007
    ..R-PK) deficiency is the most common glycolytic enzyme defect associated with hereditary non-spherocytic hemolytic anemia. Cases with the most severe deficiency die in the peri- or neonatal period and no specific therapy exists at ..
  96. ncbi Passenger lymphocyte syndrome with severe hemolytic anemia due to an anti-Jk(a) after allogeneic PBPC transplantation
    A Leo
    Institute for Immunology and the Department of Internal Medicine, University Clinics of Heidelberg, Heidelberg, Germany
    Transfusion 40:632-6. 2000
    ..After allogeneic peripheral blood progenitor cell (PBPC) transplantation, a patient developed a severe hemolytic transfusion reaction due to passenger lymphocyte syndrome...
  97. ncbi Genetic basis of hemolytic anemia caused by pyrimidine 5' nucleotidase deficiency
    A M Marinaki
    Purine Research Unit, Guy s Hospital, London, United Kingdom
    Blood 97:3327-32. 2001
    Pyrimidine 5' nucleotidase (P5'N-1) deficiency is an autosomal recessive condition causing hemolytic anemia characterized by marked basophilic stippling and the accumulation of high concentrations of pyrimidine nucleotides within the ..
  98. pmc Absence of mitochondrial superoxide dismutase results in a murine hemolytic anemia responsive to therapy with a catalytic antioxidant
    J S Friedman
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Exp Med 193:925-34. 2001
    ..Such therapy may prove useful in treatment of human disorders such as sideroblastic anemia, which SOD2 deficiency most closely resembles...
  99. ncbi An update on drug-induced immune hemolytic anemia
    G Garratty
    American Red Cross Blood Services, Southern California Region, 100 Red Cross Circle, Pomona, CA 91768, USA
    Immunohematology 23:105-19. 2007
  100. pmc Evidence for a susceptibility gene (SLEH1) on chromosome 11q14 for systemic lupus erythematosus (SLE) families with hemolytic anemia
    Jennifer A Kelly
    Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Proc Natl Acad Sci U S A 99:11766-71. 2002
    b>Hemolytic anemia is a forme fruste of systemic lupus erythematosus (SLE), being observed months or even years before the onset of other clinical manifestations in some patients...
  101. doi Brown recluse spider (Loxosceles reclusa) envenomation leading to acute hemolytic anemia in six adolescents
    Jenny McDade
    Department of Hematology, St Jude Children s Research Hospital, Memphis, TN, USA
    J Pediatr 156:155-7. 2010
    ..To highlight this important diagnostic consideration for unexplained hemolysis in areas endemic for brown recluse spiders, we report on 6 adolescents with acute hemolytic anemia from presumed L reclusa bites.

Research Grants64

  1. Molecular Biology of Human Erythrocyte Alpha Spectrin
    Patrick G Gallagher; Fiscal Year: 2013
    ..Abnormalities of ?-spectrin are associated with inherited hemolytic anemia, which is sometimes severe...
  2. Rheologic and Vascular Modulators in Sickle Vaso-occlusion
    Dhananjay K Kaul; Fiscal Year: 2012
    ..Chronic hypoxia is a predictable consequence of abnormal red cell rheology, sickling, hemolytic anemia and recurring vaso-occlusive episodes...
  3. Non-viral gene therapy for sickle cell anemia
    CLIFFORD JOHN STEER; Fiscal Year: 2012
    ..96-4057). This relentless disease, manifested by hemolytic anemia and painful vaso-occlusive crises leading to organ damage, has a significant impact on the quality and length ..
  4. Mac-1 (CR3) and Fc gamma receptors in immune-mediated neutrophil cytotoxicity
    Tanya N Mayadas; Fiscal Year: 2013
    ..the role of Vav and Rac in IgG or complement mediated phagocytosis in macrophages in models of autoimmune hemolytic anemia. We anticipate that the completion of our aims should lead to a better understanding of signaling pathways ..
  5. Therapeutic Value of Fish Oil Rx on SLE and Bone Loss in Mice
    GABRIEL J J FERNANDES; Fiscal Year: 2012
    ..Its clinical features include glomerulonephritis, cardiovascular disease (CVD), skin rashes, serositis, hemolytic anemia, impairment of the central nervous system and bone loss...
  6. Identification of a Molecular Signature for Barrier Insulators
    LAURIE ANN STEINER; Fiscal Year: 2013
    ..In addition, mutations disrupting barrier insulator function have been linked to inherited hemolytic anemia. The mechanisms underlying these aberrations in gene expression are unclear, because little is known about ..
  7. The Role of Peroxiredoxin1 &Reactive Oxygen Species in Breast Tumor Initiation
    Carola Anke Neumann; Fiscal Year: 2013
    ..We have shown that mice lacking one or two copies of the peroxidase Prdx1 die prematurely of hemolytic anemia and multiple cancers...
  8. Fc receptor targeted therapy for immune hemolytic anemia
    Periasamy Selvaraj; Fiscal Year: 2009
    ..Principal Investigator/Program Director (Last, first, middle): Selvaraj, Periasamy Abstract: Autoimmune hemolytic anemia (AIHA) is caused by the destruction of autoantibody-coated RBCs by phagocytes...
  9. Rac1 and Rac2 Guanosine Triphosphatases in Erythroid Function and Differentiation
    THEODOSIA ANASTASIOS KALFA; Fiscal Year: 2012
    ..In the long-term, this research is expected to offer new perspectives on the pathogenesis of hemolytic anemia and provide potential therapeutic targets in human disease characterized by abnormal erythropoiesis and ..
  10. Determination of a Mechanism for the Thrombocytopenia of WAS
    Ted S Strom; Fiscal Year: 2010
    ..rapid phagocytosis of platelets and red cells correlates with a proclivity toward ITP and autoimmune hemolytic anemia (AIHA). The latter is the most common of several autoimmune conditions frequently seen in WAS patients...
  11. Naphthalene exposure, chromosomal aberrations in poor urban school children.
    Manuela A Orjuela; Fiscal Year: 2012
    ..Naphthalene expo- sure is associated with hemolytic anemia in infants [2] and with DNA damage in sperm, while in vitro exposure to naphthalene metabolites is toxic to ..
  12. Interleukin-2 and autoimmune disease
    Abul K Abbas; Fiscal Year: 2012
    ..with IL-2 deficiency? The autoimmune disease of IL-2-knockout BALB/c mice is characterized by rapid-onset hemolytic anemia and lymphoproliferation, and is associated with markedly enhanced IFN-g production (Th1 responses) and ..
  13. Genetics of Autoimmune Hemolytic Anemia
    Dwight H Kono; Fiscal Year: 2013
    ..Notably, NZB.NZW-Lbw2 interval congenic mice demonstrated a marked reduction in autoimmune hemolytic anemia (AIHA) and consequent splenomegaly that was not associated with defects in immunoglobulin levels, anti-..
  14. Pathogenesis of HIV-HUS in children
    Patricio E Ray; Fiscal Year: 2012
    ..HIV-infected children can develop a severe type of Hemolytic Uremic Syndrome (HUS), characterized by hemolytic anemia and rapid progression of the renal disease, or death associated with infections, vascular leakage and ..
  15. Capping Actin Growth in Erythroid and Nonerythroid Cells
    Velia M Fowler; Fiscal Year: 2013
    ..RBCs, and in wild-type, Tmod1-null and 1/2-adducin-null mouse RBCs, and to screen as yet undiagnosed human hemolytic anemia patients for defects in TMODs;3) To determine the cellular basis for the Tmod3-null mouse fetal liver anemia, ..
  16. Molecular Regulation of Erythroid Differentiation
    Min Chen; Fiscal Year: 2013
    ..to defective mitochondrial autophagy are prone to oxidative stress, leading to increased cell turnover and hemolytic anemia. Aim 1...
  17. Membrane Proteins of Normal and Abnormal Red Cells
    David W Speicher; Fiscal Year: 2013
    ..Equally important is the fact that the mechanisms by which hereditary hemolytic anemia mutations disrupt spectrin assembly and structure are in most cases inferred with little or no real ..
  18. ANALYSIS OF MOLECULAR NETWORKS AND CONTROL SYSTEMS
    Michael A Savageau; Fiscal Year: 2013
    ..The specific aims of this proposal, which have been selected with this goal in mind, are to: (1) relate hemolytic anemia in diabetics with variants of the glucose-6-phosphate dehydrogenase enzyme to levels of oxidative stress, (2) ..
  19. EUKARYOTIC PHOSPHOFRUCTOKINASE: STRUCTURE/FUNCTION
    Teresa Ruiz; Fiscal Year: 2009
    ..g., Hemolytic anemia, Tauri's disease, non-insulin dependent diabetes mellitus)...
  20. NCMHD Southeastern Exploratory Sickle Cell Center of Excellence
    Abdullah Kutlar; Fiscal Year: 2013
    ..Because of its complex pathophysiology through chronic hemolytic anemia, microvascularocclusion, and a chronic inflammatory state, it affects multiple organ systems and leads to ..
  21. WEILL CORNELL PROGRAM OF EXCELLENCE IN GENE THERAPY
    Ronald Crystal; Fiscal Year: 2005
    ..End of Abstract) ..
  22. Functional Studies of Erythrocyte Dematin
    Athar H Chishti; Fiscal Year: 2010
    ..including the platelets and heart muscle, the proposed studies are potentially significant for understanding the molecular basis of cardiovascular diseases such as hemolytic anemia and related bleeding disorders.
  23. Cytokine Dysregulation in Autoimmune Hemolytic Anemia
    Katrina K Hoyer; Fiscal Year: 2010
    Autoimmune hemolytic anemia (AIHA) is characterized by the production of antibodies directed against self red blood cells...
  24. Transfusion Medicine/Hemostasis Clinical Research Network
    Keith R McCrae; Fiscal Year: 2012
    ..Other disorders including hemophilia, heparin-induced thrombocytopenia, and autoimmune hemolytic anemia will also provide substrates for further investigation...
  25. Cytokine Dysregulation in Autoimmune Hemolytic Anemia
    Katrina K Hoyer; Fiscal Year: 2013
    Autoimmune hemolytic anemia (AIHA) is characterized by the production of antibodies directed against self red blood cells...
  26. Study of TTP: Incidence Rates and Risk Factors
    Charles Bennett; Fiscal Year: 2005
    ..purpura (TTP) is a life-threatening disease characterized by a pentad of symptoms including microangiopathic hemolytic anemia (MAHA), thrombocytopenia, neurologic symptoms, fever, and renal dysfunction...
  27. INHIBITION OF NONERYTHROID SPECTRIN BY ANTISENSE RNA
    Randall Moon; Fiscal Year: 1993
    ..in human diseases since defects in the alpha-subunit of spectrin in red blood cells are linked to hereditary hemolytic anemia. A related spectrin, termed fodrin, is encoded by different genes and is present in muscle...
  28. GENE TARGETED MICE WITH A SIMPLIFIED IMMUNE SYSTEM
    MATTHIAS R WABL; Fiscal Year: 2013
    ..ii) Similarly, an integrase inhibitor that accumulates endogenous retroelement cDNA exacerbates lupus and hemolytic anemia in mice...
  29. Assembly of Spectrin Isoforms
    LESLIE FUNG; Fiscal Year: 2009
    ..brain cells and other types of cells, and of diseases related to spectrin tetramers, such as hereditary hemolytic anemia, and neurological disorders...
  30. PRIMAQUINE-INDUCED HEMOLYTIC ANEMIA
    DAVID MC MILLAN; Fiscal Year: 2004
    ..However, primaquine therapy has been severely limited because of its capacity to induce methemoglobinemia and hemolytic anemia, particularly in patients with glucose-6-phosphate dehydrogenase deficiency...
  31. INACTIVATION OF THE PIGA GENE IN HEMATOPOIETIC STEM CELL
    Monica Bessler; Fiscal Year: 2002
    ..In patients with Paroxysmal Nocturnal Hemoglobinuria (PNH), an acquired hemolytic anemia, a somatic mutation in the X linked PIGA gene occurs in a hematopoietic stem cell...
  32. MECHANISM OF DIVICINE TOXICITY
    DAVID MC MILLAN; Fiscal Year: 1999
    ..These pyrimidine aglycones have been implicated as the causative factors in a life-threatening hemolytic anemia known as favism...
  33. ANIMAL MODEL OF DRUG-INDUCED SLE
    David Aucoin; Fiscal Year: 1990
    ..This syndrome is characterized by lethergy, anoerexia, lymphadenopathy, severe hemolytic anemia, positive Coombs' test and antinuclear antibodies...
  34. Hemolytic Anemia: Biochemical, Molecular and Proteomic Diagnostics
    Jeffrey S Friedman; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Hemolytic Anemia: Biochemical, Molecular and Proteomic Diagnostics The hereditary hemolytic anemias, comprising both enzyme deficiencies and red cell membrane protein defects are a heterogeneous group ..
  35. GLOBIN GENE TRANSFER FOR THERAPY OF SICKLE CELL ANEMIA
    Michel Sadelain; Fiscal Year: 2004
    ..Sickle cell anemia is one of the commonest inherited diseases in humans, characterized by a severe chronic hemolytic anemia with an unpredictable course...
  36. GLYCOLIPIDS AND HEMOLYTIC UREMIC SYNDROME
    David Haslam; Fiscal Year: 2002
    ..uremic syndrome (HUS) is characterized by verotoxin-mediated damage to endothelial cells that results in hemolytic anemia, throbocytopenia, and multisystemic complications including renal failure...
  37. NHLBI MINORITY INSTITUTION RESEARCH SCIENTIST DEVELOPMEN
    MARIA DEL PILAR AGUINAGA; Fiscal Year: 2004
    ..from applicant's abstract) Sickle cell disease is a serious hemoglobin disorder characterized by a chronic hemolytic anemia with recurrent vasoocclusive episodes, secondary complications, impaired quality of life and a reduced life ..
  38. MOLECULAR BIOLOGY OF HUMAN ERYTHROCYTE ANKYRIN
    Patrick Gallagher; Fiscal Year: 2000
    ..the identification of ankyrin mutations n patients with hereditary spherocytosis (HS), a common inherited hemolytic anemia, and characterization of the structural and/or functional significance of these abnormalities...
  39. Bartonella Inhibitory Factor for Endothelial Cell Growth
    MICHAEL MINNICK; Fiscal Year: 2002
    ..manifestations including endocarditis, bacillary angiomatosis, peliosis, chronic bacteremia, and hemolytic anemia. Bartonella's parasitism of microvascular endothelial cells is characterized by a proliferative response ..
  40. SPLENIC TOXICITY OF ANILINE
    M Firoze Khan; Fiscal Year: 1999
    ..The hemopoietic system is an early target of aniline insult. Besides causing methemoglobinemia and hemolytic anemia, aniline exposure also results in selective splenic toxicity leading to splenomegaly, hemorrhage, capsular ..
  41. CHLOROANILINE-INDUCED NEPHROTOXICITY
    GARY RANKIN; Fiscal Year: 1992
    ..chlorinated derivatives produce a spectrum of toxicities which include hematotoxicity (methemoglobinemia, hemolytic anemia), nephrotoxicity (oliguria, hematuria, tubular necrosis) and to a lesser extent, hepatotoxicity...
  42. Protein Signatures of Normal versus Paroxysmal Nocturnal Hemoglobinuria Platelets
    Monica Bessler; Fiscal Year: 2007
    ..DESCRIPTION (provided by applicant): [unreadable] Paroxysmal nocturnal hemoglobinuria is an acquired hemolytic anemia characterized by the increased sensitivity of red cells to complement leading to intravascular hemolysis and ..
  43. Induction of Tissue Factor by Patient Sera in HUS
    Eric Grabowski; Fiscal Year: 2007
    ..Diarrhea-positive Hemolytic Uremic Syndrome (D+ HUS) is a serious disease in children that causes hemolytic anemia, thrombocytopenia, and acute renal failure...
  44. CHARACTERIZATION OF AUTOANTIBODIES IN IMMUNE CYTOPENIAS
    Denise Shaw; Fiscal Year: 1992
    ..etiologies of chronic autoimmune cytopenias like idiopathic thrombocytopenic purpura (AITP) and warm-reactive hemolytic anemia (AIHA) are unknown...
  45. Hemolytic Anemia: Models
    LUANNE PETERS; Fiscal Year: 2006
    ..5 isoform in the structure and assembly of the sarcoplasmic reticulum by an in vivo developmental study. ..
  46. Immunodeficiencies and Autoimmune Diseases (a Scientific Colloquium)
    Noel Rose; Fiscal Year: 2009
    ..CVID), a B cell defect, develop an autoimmune condition such as idiopathic thrombocytopenia (ITP), hemolytic anemia, rheumatoid arthritis, sicca syndrome, primary biliary cirrhosis, and pernicious anemia...
  47. Functions of pRb in Stress Erythropoiesis
    Kay Macleod; Fiscal Year: 2009
    ..We have shown that under stress conditions, such as hemolytic anemia, bone marrow transplant or tumorigenesis, pRb is required to regulate erythroblast expansion and to ..
  48. MECHANISMS OF ENDOTHELIAL CELL INJURY IN TTP/HUS
    Jerome Gottschall; Fiscal Year: 1999
    Thrombotic thrombocytopenic purpura (TTP) is a multi-system disorder characterized by micro angiopathic hemolytic anemia, thrombocytopenia, neurologic abnormalities, and less commonly, fever and renal abnormalities...
  49. GENETIC ANALYSIS--DYSERYTHROPOIETIC ANEMIA IN ZEBRAFISH
    Barry Paw; Fiscal Year: 2000
    ..syndromes, leukemia megaloblastic anemia, HIV infection, recovery from bone marrow transplantation, and hemolytic anemia. A full understanding of this marrow stress response awaits identification of genes involved in this cascade ..
  50. The Role of Alpha Hemoglobin Stabilizing Protein in Human Beta Thalassemia
    Mitchell J Weiss; Fiscal Year: 2010
    ..Ahsp-/- mice exhibit hemolytic anemia with Hb precipitates and excessive ROS...
  51. Proinflammatory signaling in the kidney by Shiga toxin
    KRISTIN SAUTER; Fiscal Year: 2009
    ..syndrome (HUS), a common cause of acute renal failure in children, is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and renal failure. HUS is caused by Shiga-toxin producing E.coli of serotype O157:H7...
  52. INHIBITION OF NONERYTHROID SPECTRIN BY ANTISENSE RNA
    Randall Moon; Fiscal Year: 1991
    ..in human disease since defects in the alpha-subunit of spectrin in red blood cells are linked to hereditary hemolytic anemia. A related spectrin, termed fodrin, is encoded by different genes and is present in muscle...
  53. NHLBI MINORITY INSTITUTION FACULTY MENTORED RESEARCH
    Harpal Singh; Fiscal Year: 2001
    ..David Jollow, and will be concerned with the an aspect of the mechanisms underlying the hemolytic anemia that occurs in man and animals in response to arylamine drugs and environmental chemicals...
  54. GENETIC INTERACTIONS IN RED CELL MEMBRANE DISEASE
    LUANNE PETERS; Fiscal Year: 2003
    Hereditary spherocytosis (HS), a common inherited hemolytic anemia, results from defects in the red blood cell (RBC) spectrin-based membrane skeleton, a multicomponent structure crucial to RBC mechanical stability...
  55. DEFERIPRONE THERAPY FOR SICKLE CELL DISEASE
    Nancy Olivieri; Fiscal Year: 2001
    ..to determine if administration of the orally active iron chelator deferiprone can ameliorate the chronic hemolytic anemia of sickle cell disease by inhibiting iron-induced oxidative damage to the sickle erythrocyte membrane and ..
  56. ADDUCIN ISOFORMS IN RBC AND PLATELET DIFFERENTIATION
    DIANA GILLIGAN; Fiscal Year: 2003
    ..Defects in membrane skeleton proteins cause mild to severe hemolytic anemia and even hydrops fetalis...
  57. RETROVIRAL TRANSFER OF ANKYRIN FOR SPHEROCYTOSIS
    Pamela Becker; Fiscal Year: 2002
    ..We-will use the nb/nb mouse as our hemolytic anemia model and study the impact of stem cell cycle status and low dose (100 cGy) host irradiation (minimal ..
  58. SICKLING MECHANISMS AND RED CELL MEMBRANES
    ROBERT BOOKCHIN; Fiscal Year: 2002
    ..with the RBC membranes to alter cell functions, leading clinically to widespread microvascular occlusion and hemolytic anemia. Our immediate aims are: I...
  59. TRANSLATIONAL CONTROL OF ADENOSINE DEAMINASE
    Elaine Chottiner; Fiscal Year: 1990
    Elevated erythrocyte adenosine deaminase (ADA) activity has been reported in association with hereditary hemolytic anemia (Valentine et al., Science 195:783-5, 1977)...
  60. OVERPRODUCTION OF ADENOSINE DEAMINASE IN ERYTHROCYTES
    Beverly Mitchell; Fiscal Year: 1993
    ..but not in leukocytes, B lymphoblasts, or fibroblasts, from a kindred with an autosomal dominant form of hemolytic anemia. The elevated red cell ADA activity is associated with normal catalytic properties of the enzyme and normal ..
  61. Engineering proteins to target repair of human disease-causing mutations
    Umut Ulge; Fiscal Year: 2009
    ..PKD is the most common human heritable glycolytic defect, and is the second most common cause of hemolytic anemia. It represents an ideal target disease for repair for several important reasons: the mutations in the ..
  62. DECIPHERING THE FUNCTION OF THE RH BLOOD GROUP PROTEINS
    Connie Westhoff; Fiscal Year: 2002
    ..role in the erythrocyte membrane, as individuals who lack expression of all Rh antigens suffer from chronic hemolytic anemia. The eventual, long-term goal of this project is to decipher the function of the Rh proteins, characterize ..
  63. SHIGA LIKE TOXIN AND RENAL CELL DYSFUNCTION
    Donald Kohan; Fiscal Year: 2001
    ..The HUS is characterized by acute renal injury, microangiopathic hemolytic anemia, and thrombocytopenia...
  64. The role of regulatory T cells in maintaining B cell tolerance
    Daniel Campbell; Fiscal Year: 2007
    ..autoimmune diseases, such as systemic lupus erythematosus, idiopathic thrombocytopenia purpura, autoimmune hemolytic anemia, and myasthenia gravis...