anemia

Summary

Summary: A reduction in the number of circulating erythrocytes or in the quantity of hemoglobin.

Top Publications

  1. ncbi Anemia of chronic disease
    Guenter Weiss
    Department of General Internal Medicine, Clinical Immunology and Infectious Diseases, Medical University of Innsbruck, Innsbruck, Austria
    N Engl J Med 352:1011-23. 2005
  2. pmc Influence of the timing of malaria infection during pregnancy on birth weight and on maternal anemia in Benin
    Bich Tram Huynh
    Institut de Recherche pour le Developpement, Mère et Enfant Face aux Infections Tropicales, Paris, France
    Am J Trop Med Hyg 85:214-20. 2011
  3. pmc IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
    Elizabeta Nemeth
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles UCLA, Los Angeles, California, USA
    J Clin Invest 113:1271-6. 2004
  4. doi Anaemia in low-income and middle-income countries
    Yarlini Balarajan
    Department of Global Health and Population, Harvard School of Public Health, Boston, MA 02115 6096, USA
    Lancet 378:2123-35. 2011
  5. pmc Vivax malaria: a major cause of morbidity in early infancy
    Jeanne R Poespoprodjo
    District Health Authority, Menzies School of Health Research, National Institute of Health Research and Development Malaria Research Program, Jakarta, Indonesia
    Clin Infect Dis 48:1704-12. 2009
  6. pmc Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo
    M Mortensen
    Nuffield Department of Medicine, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom
    Proc Natl Acad Sci U S A 107:832-7. 2010
  7. ncbi An iron-regulated ferric reductase associated with the absorption of dietary iron
    A T McKie
    Department of Molecular Medicine, Guy s, King s and St Thomas School of Medicine, King s College London, Rayne Institute, Denmark Hill Campus, 123 Coldharbour Lane, London SE5 9NU, UK
    Science 291:1755-9. 2001
  8. ncbi Effects of Plasmodium vivax malaria in pregnancy
    F Nosten
    Shokio Malaria Research Unit, Mae Sot, Thailand
    Lancet 354:546-9. 1999
  9. pmc A systematic analysis of global anemia burden from 1990 to 2010
    Nicholas J Kassebaum
    Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA
    Blood 123:615-24. 2014
  10. pmc The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation
    Gael Nicolas
    Département de génétique, Developpement et Pathologie Moleculaire, Institut Cochin, INSERM, Centre National de la Recherche Scientifique, et Université René Descartes, Faculté de Médecine Cochin Port Royal, Paris, France
    J Clin Invest 110:1037-44. 2002

Research Grants

  1. Intestinal Iron Transport in Iron Deficiency/Anemia
    James Collins; Fiscal Year: 2005
  2. Robert T Means; Fiscal Year: 2014
  3. Donald A McClain; Fiscal Year: 2016
  4. Hepcidin-based screening for infantile iron deficiency
    Mark D Fleming; Fiscal Year: 2010
  5. Role of the Mammalian Siderophore in Cellular Iron Metabolism and Erythropoiesis
    Laxminarayana R Devireddy; Fiscal Year: 2012
  6. Jianming Qiu; Fiscal Year: 2016
  7. Twenty-second Annual Fanconi Anemia Research Fund Scientific Symposium
    GROVER CARLTON BAGBY; Fiscal Year: 2010
  8. 24th Annual Fanconi Anemia Research Fund Scientific Symposium
    GROVER CARLTON BAGBY; Fiscal Year: 2012
  9. Mechanisms of Endothelin 1-Induced Sickle Cell Pathology
    Alicia Rivera; Fiscal Year: 2011
  10. Mechanisms of Heme Transport in Macrophages
    CARINE CARINE WHITE; Fiscal Year: 2012

Detail Information

Publications512 found, 100 shown here

  1. ncbi Anemia of chronic disease
    Guenter Weiss
    Department of General Internal Medicine, Clinical Immunology and Infectious Diseases, Medical University of Innsbruck, Innsbruck, Austria
    N Engl J Med 352:1011-23. 2005
  2. pmc Influence of the timing of malaria infection during pregnancy on birth weight and on maternal anemia in Benin
    Bich Tram Huynh
    Institut de Recherche pour le Developpement, Mère et Enfant Face aux Infections Tropicales, Paris, France
    Am J Trop Med Hyg 85:214-20. 2011
    ..The objective was to evaluate the relationship between the timing of infection and birth weight, and maternal anemia at delivery...
  3. pmc IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
    Elizabeta Nemeth
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles UCLA, Los Angeles, California, USA
    J Clin Invest 113:1271-6. 2004
    ....
  4. doi Anaemia in low-income and middle-income countries
    Yarlini Balarajan
    Department of Global Health and Population, Harvard School of Public Health, Boston, MA 02115 6096, USA
    Lancet 378:2123-35. 2011
    ..Reduction of knowledge gaps in research and policy and improvement of the implementation of effective population-level strategies will help to alleviate the anaemia burden in low-resource settings...
  5. pmc Vivax malaria: a major cause of morbidity in early infancy
    Jeanne R Poespoprodjo
    District Health Authority, Menzies School of Health Research, National Institute of Health Research and Development Malaria Research Program, Jakarta, Indonesia
    Clin Infect Dis 48:1704-12. 2009
    ..In areas where malaria is endemic, infants aged <3 months appear to be relatively protected from symptomatic and severe Plasmodium falciparum malaria, but less is known about the effect of Plasmodium vivax infection in this age group...
  6. pmc Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo
    M Mortensen
    Nuffield Department of Medicine, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom
    Proc Natl Acad Sci U S A 107:832-7. 2010
    ..Here we show that mice lacking the essential autophagy gene Atg7 in the hematopoietic system develop severe anemia. Atg7(-/-) erythrocytes accumulate damaged mitochondria with altered membrane potential leading to cell death...
  7. ncbi An iron-regulated ferric reductase associated with the absorption of dietary iron
    A T McKie
    Department of Molecular Medicine, Guy s, King s and St Thomas School of Medicine, King s College London, Rayne Institute, Denmark Hill Campus, 123 Coldharbour Lane, London SE5 9NU, UK
    Science 291:1755-9. 2001
    ..Duodenal expression levels of Dcytb messenger RNA and protein were regulated by changes in physiological modulators of iron absorption. Thus, Dcytb provides an important element in the iron absorption pathway...
  8. ncbi Effects of Plasmodium vivax malaria in pregnancy
    F Nosten
    Shokio Malaria Research Unit, Mae Sot, Thailand
    Lancet 354:546-9. 1999
    ..P. falciparum infection has harmful effects in pregnancy, but the effects of P. vivax have not been characterised. We investigated the effects of P. vivax infection during pregnancy...
  9. pmc A systematic analysis of global anemia burden from 1990 to 2010
    Nicholas J Kassebaum
    Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA
    Blood 123:615-24. 2014
    Previous studies of anemia epidemiology have been geographically limited with little detail about severity or etiology...
  10. pmc The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation
    Gael Nicolas
    Département de génétique, Developpement et Pathologie Moleculaire, Institut Cochin, INSERM, Centre National de la Recherche Scientifique, et Université René Descartes, Faculté de Médecine Cochin Port Royal, Paris, France
    J Clin Invest 110:1037-44. 2002
    ..Hepcidin mRNA levels were assessed in two models of anemia, acute hemolysis provoked by phenylhydrazine and bleeding provoked by repeated phlebotomies...
  11. ncbi Association of hemoglobin levels with clinical outcomes in acute coronary syndromes
    Marc S Sabatine
    TIMI Study Group, Cardiovascular Division, Brigham and Women s Hospital, Boston, Mass 02115, USA
    Circulation 111:2042-9. 2005
    In the setting of an acute coronary syndrome (ACS), anemia has the potential to worsen myocardial ischemia; however, data relating anemia to clinical outcomes in ACS remain limited.
  12. pmc Underlying factors associated with anemia in Amazonian children: a population-based, cross-sectional study
    Marly A Cardoso
    Department of Nutrition, School of Public Health, University of Sao Paulo, Sao Paulo, Brazil
    PLoS ONE 7:e36341. 2012
    Although iron deficiency is considered to be the main cause of anemia in children worldwide, other contributors to childhood anemia remain little studied in developing countries...
  13. pmc The anaemia of Plasmodium vivax malaria
    Nicholas M Douglas
    Global Health Division, Menzies School of Health Research, PO Box 41096, Casuarina, NT 0811, Australia
    Malar J 11:135. 2012
    ..Anaemia can be averted by early and effective anti-malarial treatment...
  14. pmc Association of maternal height with child mortality, anthropometric failure, and anemia in India
    S V Subramanian
    Department of Society, Human Development, and Health, Harvard School of Public Health, Boston, MA 02115, USA
    JAMA 301:1691-701. 2009
    ..Research on intergenerational factors that might also predispose a child to increased health adversity remains limited...
  15. ncbi An analysis of anemia and child mortality
    B J Brabin
    Liverpool School of Tropical Medicine, Liverpool, England
    J Nutr 131:636S-645S; discussion 646S-648S. 2001
    The relationship of anemia as a risk factor for child mortality was analyzed by using cross-sectional, longitudinal and case-control studies, and randomized trials...
  16. doi Iron metabolism in the anemia of chronic disease
    Gunter Weiss
    Department of Internal Medicine I, Clinical Immunology and Infectious Diseases, Medical University, Anichstr 35, A 6020 Innsbruck, Austria
    Biochim Biophys Acta 1790:682-93. 2009
    The most frequent clinical condition exemplifying the interplay between iron and immune function is the anemia of chronic disease (ACD).
  17. doi The relationship between age and the manifestations of and mortality associated with severe malaria
    Arjen M Dondorp
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Clin Infect Dis 47:151-7. 2008
    ..The reported case-fatality rate associated with severe malaria varies widely. Whether age is an independent risk factor is uncertain...
  18. ncbi Anemia is associated with disability and decreased physical performance and muscle strength in the elderly
    Brenda W J H Penninx
    Sticht Center on Aging, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    J Am Geriatr Soc 52:719-24. 2004
    To examine the association between anemia and disability, physical performance, and muscle strength in older persons.
  19. pmc Severe falciparum malaria in Gabonese children: clinical and laboratory features
    Arnaud Dzeing-Ella
    Department of Parasitology, Mycology and Tropical Medicine, Faculty of Medicine, University of Health Sciences USS, Libreville, Gabon
    Malar J 4:1. 2005
    ..This study examined the prognostic indicators of severe falciparum malaria in Gabonese children...
  20. ncbi Impact of medical complications on outcome after subarachnoid hemorrhage
    Katja E Wartenberg
    Clinical Neuropsychology, New York Presbyterian Hospital, and Stroke and Critical Care, Columbia University, New York, NY, USA
    Crit Care Med 34:617-23; quiz 624. 2006
    ..Medical complications occur frequently after subarachnoid hemorrhage (SAH). Their impact on outcome remains poorly defined...
  21. doi Anemia and patient blood management in hip and knee surgery: a systematic review of the literature
    Donat R Spahn
    Institute of Anesthesiology, University Hospital and University of Zurich, Zurich, Switzerland
    Anesthesiology 113:482-95. 2010
    A systematic search was conducted to determine the characteristics of perioperative anemia, its association with clinical outcomes, and the effects of patient blood management interventions on these outcomes in patients undergoing major ..
  22. pmc Impact of hookworm infection and deworming on anaemia in non-pregnant populations: a systematic review
    Jennifer L Smith
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, UK
    Trop Med Int Health 15:776-95. 2010
    ....
  23. ncbi Low plasma concentrations of interleukin 10 in severe malarial anaemia compared with cerebral and uncomplicated malaria
    J A Kurtzhals
    Immunology Unit, Noguchi Memorial Institute for Medical Research, Legon, Ghana
    Lancet 351:1768-72. 1998
    ..Conversely, interleukin 10 (IL-10), which mediates feed-back regulation of TNF, stimulates bone-marrow function in vitro and counteracts anaemia in mice. We investigated the associations of these cytokines with malarial anaemia...
  24. doi Severe anemia in Malawian children
    Job C J Calis
    Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, Blantyre, Malawi
    N Engl J Med 358:888-99. 2008
    Severe anemia is a major cause of sickness and death in African children, yet the causes of anemia in this population have been inadequately studied.
  25. ncbi Novel erythropoiesis-stimulating agents: a new era in anemia management
    Iain C Macdougall
    Department of Renal Medicine, King s College Hospital, London, United Kingdom
    Clin J Am Soc Nephrol 3:200-7. 2008
    Nearly two decades ago, recombinant human erythropoietin transformed the management of chronic kidney disease anemia by allowing a more sustained increase in hemoglobin than was possible by intermittent blood transfusion...
  26. pmc PSMB8 encoding the β5i proteasome subunit is mutated in joint contractures, muscle atrophy, microcytic anemia, and panniculitis-induced lipodystrophy syndrome
    Anil K Agarwal
    Department of Internal Medicine, Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    Am J Hum Genet 87:866-72. 2010
    ..an autosomal-recessive autoinflammatory syndrome characterized by joint contractures, muscle atrophy, microcytic anemia, and panniculitis-induced lipodystrophy (JMP). This revealed only one homozygous region spanning 2...
  27. pmc Targeting the hepcidin-ferroportin axis to develop new treatment strategies for anemia of chronic disease and anemia of inflammation
    Chia Chi Sun
    Program in Membrane Biology, Division of Nephrology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am J Hematol 87:392-400. 2012
    b>Anemia of chronic disease (ACD) or anemia of inflammation is prevalent in patients with chronic infection, autoimmune disease, cancer, and chronic kidney disease. ACD is associated with poor prognosis and lower quality of life...
  28. pmc The effects of the anti-hepcidin Spiegelmer NOX-H94 on inflammation-induced anemia in cynomolgus monkeys
    Frank Schwoebel
    NOXXON Pharma AG, Berlin, Germany
    Blood 121:2311-5. 2013
    b>Anemia of chronic inflammation is the most prevalent form of anemia in hospitalized patients. A hallmark of this disease is the intracellular sequestration of iron...
  29. ncbi Impact of preoperative anemia on outcome in patients undergoing coronary artery bypass graft surgery
    Alexander Kulier
    Department of Anesthesiology and Intensive Care Medicine, Medical University of Graz, Graz, Austri
    Circulation 116:471-9. 2007
    The risk of preoperative anemia in patients undergoing heart surgery has not been described precisely. Specifically, the impact of low hemoglobin per se or combined with other risk factors on postoperative outcome is unknown...
  30. ncbi Reassessment of the cost of chronic helmintic infection: a meta-analysis of disability-related outcomes in endemic schistosomiasis
    Charles H King
    Center for Global Health and Diseases, Wolstein 4126, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 7286, USA
    Lancet 365:1561-9. 2005
    ..To develop an evidenced-based reassessment of schistosomiasis-related disability, we did a systematic review of data on disability-associated outcomes for all forms of schistosomiasis...
  31. doi Preoperative anaemia and postoperative outcomes in non-cardiac surgery: a retrospective cohort study
    Khaled M Musallam
    Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
    Lancet 378:1396-407. 2011
    ..We aimed to assess the effect of preoperative anaemia on 30-day postoperative morbidity and mortality in patients undergoing major non-cardiac surgery...
  32. ncbi The prognostic and pathophysiologic role of pro- and antiinflammatory cytokines in severe malaria
    N P Day
    Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DU, United Kingdom
    J Infect Dis 180:1288-97. 1999
    ..Both the overall magnitude of the cytokine responses and the eventual imbalance between the pro- and antiinflammatory responses are important determinants of mortality...
  33. ncbi Treatment resistance of solid tumors: role of hypoxia and anemia
    P Vaupel
    Institute of Physiology and Pathophysiology, University of Mainz, Germany
    Med Oncol 18:243-59. 2001
    ..of the tumor microvasculature, (2) increased diffusion distances, and (3) tumor-associated and therapy-induced anemia. The oxygenation status is independent of clinical tumor size, stage, grade, and histopathological type, but is ..
  34. ncbi Hemoglobin level, chronic kidney disease, and the risks of death and hospitalization in adults with chronic heart failure: the Anemia in Chronic Heart Failure: Outcomes and Resource Utilization (ANCHOR) Study
    Alan S Go
    Division of Research, Kaiser Permanente of Northern California, 2000 Broadway St, 3rd Floor, Oakland, California 94612 2304, USA
    Circulation 113:2713-23. 2006
    ..It is unclear, however, whether this relation is explained by underlying kidney disease, treatment differences, or associated comorbidity...
  35. pmc Factors contributing to anemia after uncomplicated falciparum malaria
    R N Price
    Shoklo Malaria Research Unit, Mae Sod, Tak Province, Thailand
    Am J Trop Med Hyg 65:614-22. 2001
    The factors contributing to anemia in falciparum malaria were characterized in 4,007 prospectively studied patients on the western border of Thailand...
  36. pmc Patterns and risk factors of helminthiasis and anemia in a rural and a peri-urban community in Zanzibar, in the context of helminth control programs
    Stefanie Knopp
    Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS Negl Trop Dis 4:e681. 2010
    The control of helminth infections and prevention of anemia in developing countries are of considerable public health importance...
  37. pmc The definition of anemia: what is the lower limit of normal of the blood hemoglobin concentration?
    Ernest Beutler
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Blood 107:1747-50. 2006
    The diagnosis of anemia is an important aspect of the practice of hematology. The first step is to decide whether the patient is, in fact, anemic...
  38. pmc Epidemiology of plasmodium-helminth co-infection in Africa: populations at risk, potential impact on anemia, and prospects for combining control
    Simon Brooker
    London School of Hygiene and Tropical Medicine, Kepel Street, London, United Kingdom
    Am J Trop Med Hyg 77:88-98. 2007
    ..falciparum and hookworm has an additive impact on hemoglobin, exacerbating anemia-related malarial disease burden...
  39. ncbi Placental monocyte infiltrates in response to Plasmodium falciparum malaria infection and their association with adverse pregnancy outcomes
    Stephen J Rogerson
    Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Blantyre, Malawi
    Am J Trop Med Hyg 68:115-9. 2003
    Maternal anemia and low birth weight (LBW) may complicate malaria in pregnancy, and placental monocyte infiltrates have been associated with LBW, and anecdotally with anemia. We examined placental pathology from 357 Malawian women...
  40. pmc Predictors of mortality in HIV-infected patients starting antiretroviral therapy in a rural hospital in Tanzania
    Asgeir Johannessen
    Department of Infectious Diseases, Ulleval University Hospital, Oslo, Norway
    BMC Infect Dis 8:52. 2008
    ..Factors contributing to this high mortality are poorly described. The aim of the present study was to assess mortality and to identify predictors of mortality in HIV-infected patients starting ART in a rural hospital in Tanzania...
  41. pmc Anemia of inflammation: the cytokine-hepcidin link
    Nancy C Andrews
    Children s Hospital, Howard Hughes Medical Institute, Harvard Medical School, and Dana Farber Cancer Institute, Boston, Massachusetts 02115 5737, USA
    J Clin Invest 113:1251-3. 2004
    The anemia of inflammation, commonly observed in patients with chronic infections, malignancy, trauma, and inflammatory disorders, is a well-known clinical entity. Until recently, we understood little about its pathogenesis...
  42. pmc Vascular endothelium as a contributor of plasma sphingosine 1-phosphate
    Krishnan Venkataraman
    Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Circ Res 102:669-76. 2008
    ..These data suggest that the vascular endothelium, in addition to the hematopoietic system, is a major contributor of plasma S1P...
  43. ncbi Left ventricular mass index increase in early renal disease: impact of decline in hemoglobin
    A Levin
    Centre for Health Outcomes and Evaluation Sciences, St Paul s Hospital, Vancouver, Canada
    Am J Kidney Dis 34:125-34. 1999
    ..We defined the important modifiable risk factors. There remains a critical need to establish optimal therapeutic strategies and targets to improve clinical outcomes...
  44. ncbi Longitudinal follow-up and outcomes among a population with chronic kidney disease in a large managed care organization
    Douglas S Keith
    Division of Nephrology and Hypertension, Oregon Health and Science University, USA
    Arch Intern Med 164:659-63. 2004
    ..The purpose of this study was to understand the natural history of chronic kidney disease with regard to progression to renal replacement therapy (transplant or dialysis) and death in a representative patient population...
  45. doi Recombinant human erythropoiesis-stimulating agents and mortality in patients with cancer: a meta-analysis of randomised trials
    Julia Bohlius
    Institute of Social and Preventive Medicine ISPM, University of Bern, Bern, Switzerland
    Lancet 373:1532-42. 2009
    ..We therefore did a meta-analysis of randomised controlled trials in which these drugs plus red blood cell transfusions were compared with transfusion alone for prophylaxis or treatment of anaemia in patients with cancer...
  46. ncbi Prevalence and correlates of anemia in a large cohort of HIV-infected women: Women's Interagency HIV Study
    A M Levine
    University of Southern California School of Medicine, Los Angeles, California, USA
    J Acquir Immune Defic Syndr 26:28-35. 2001
    b>Anemia is a common manifestation of HIV infection, occurring in approximately 30% of patients with asymptomatic infection and in as many as 75% to 80% of those with AIDS...
  47. ncbi Anemia as an independent prognostic factor for survival in patients with cancer: a systemic, quantitative review
    J J Caro
    Division of General Internal Medicine, McGill University, Montreal, Quebec, Canada
    Cancer 91:2214-21. 2001
    b>Anemia is common in cancer patients, although the prevalence is influenced both by the type of malignancy and the choice of treatment...
  48. pmc Severe malarial anemia: innate immunity and pathogenesis
    Douglas J Perkins
    Center for Global Health, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque NM, USA
    Int J Biol Sci 7:1427-42. 2011
    ..more life-threatening complications, including: hyperparasitemia; hypoglycemia; cerebral malaria; severe malarial anemia (SMA); and respiratory distress...
  49. doi Treatment of anemia with darbepoetin alfa in systolic heart failure
    Karl Swedberg
    Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    N Engl J Med 368:1210-9. 2013
    Patients with systolic heart failure and anemia have worse symptoms, functional capacity, and outcomes than those without anemia...
  50. doi A mouse model of anemia of inflammation: complex pathogenesis with partial dependence on hepcidin
    Airie Kim
    Department of Medicine, and
    Blood 123:1129-36. 2014
    b>Anemia is a common complication of infections and inflammatory diseases, but the few mouse models of this condition are not well characterized...
  51. ncbi An analysis of anemia and pregnancy-related maternal mortality
    B J Brabin
    Liverpool School of Tropical Medicine, Liverpool, England
    J Nutr 131:604S-614S; discussion 614S-615S. 2001
    The relationship of anemia as a risk factor for maternal mortality was analyzed by using cross-sectional, longitudinal and case-control studies because randomized trials were not available for analysis...
  52. ncbi A GATA-specific inhibitor (K-7174) rescues anemia induced by IL-1beta, TNF-alpha, or L-NMMA
    Shigehiko Imagawa
    Division of Hematology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    FASEB J 17:1742-4. 2003
    ..TNF-alpha), or N(G)-monomethyl-L-arginine (L-NMMA) are increased in patients with chronic disease-related anemia. They increase the binding activity of GATA and inhibit erythropoietin (Epo) promoter activity...
  53. ncbi Ferric gluconate is highly efficacious in anemic hemodialysis patients with high serum ferritin and low transferrin saturation: results of the Dialysis Patients' Response to IV Iron with Elevated Ferritin (DRIVE) Study
    Daniel W Coyne
    Washington University School of Medicine, 660 S Euclid Avenue, Campus Box 8129, St Louis, MO 63110, USA
    J Am Soc Nephrol 18:975-84. 2007
    ..Administration of ferric gluconate (125 mg for eight treatments) is superior to no iron therapy in anemic dialysis patients receiving adequate epoetin dosages and have a ferritin 500 to 1200 ng/ml and TSAT <or=25%...
  54. pmc Erythropoiesis-stimulating agents in oncology: a study-level meta-analysis of survival and other safety outcomes
    J Glaspy
    Department of Medicine Hematology and Oncology, David Geffen School of Medicine at University of California, Los Angeles, 100 UCLA Medical Plaza, Suite 550, Los Angeles, CA 90095 6996 USA
    Br J Cancer 102:301-15. 2010
    ..To evaluate recent safety concerns regarding ESAs, we carried out a meta-analysis of controlled ESA oncology trials to examine whether ESA use affects survival, disease progression and risk of venous-thromboembolic events...
  55. pmc Anemia and iron homeostasis in a cohort of HIV-infected patients in Indonesia
    Rudi Wisaksana
    Department of Internal Medicine Faculty of Medicine, Padjadjaran University Hasan Sadikin Hospital, Bandung, Indonesia
    BMC Infect Dis 11:213. 2011
    b>Anemia is a common clinical finding in HIV-infected patients and iron deficiency or redistribution may contribute to the development of low hemoglobin levels...
  56. pmc Prevalence and pathogenesis of anemia in inflammatory bowel disease. Influence of anti-tumor necrosis factor-alpha treatment
    Gaetano Bergamaschi
    Clinica, Medica I, Policlinico San Matteo, Piazzale Golgi, 27100 Pavia, Italy
    Haematologica 95:199-205. 2010
    b>Anemia is a common complication of inflammatory bowel disease, but its epidemiology may be changing due to earlier diagnosis and improved treatments...
  57. doi 2008 Japanese Society for Dialysis Therapy: guidelines for renal anemia in chronic kidney disease
    Yoshiharu Tsubakihara
    Department of Kidney Disease and Hypertension, Osaka General Medical Center, Sumiyoshi ku, Osaka, Japan
    Ther Apher Dial 14:240-75. 2010
    ..Tsubakihara, presents the Japanese guidelines entitled "Guidelines for Renal Anemia in Chronic Kidney Disease...
  58. ncbi Prevalence, incidence and predictors of severe anaemia with zidovudine-containing regimens in African adults with HIV infection within the DART trial
    Francis Ssali
    Joint Clinical Research Centre, Kampala, Uganda
    Antivir Ther 11:741-9. 2006
    ..To describe the prevalence, incidence and predictors of severe anaemia in previously untreated symptomatic HIV-infected adults with CD4+ T-cells <200 cells/mm(3) initiating zidovudine-containing regimens in Africa...
  59. ncbi Risk factors for moderate to severe anemia among children in Benin and Mali: insights from a multilevel analysis
    Ismael Ngnie-Teta
    PATH Canada, Suite 1105, One Nicholas Street, Ottawa, Ontario K1N 7B7, Canada
    Food Nutr Bull 28:76-89. 2007
    b>Anemia currently affects 2 billion people throughout the world...
  60. doi Differing effects of HbS and HbC traits on uncomplicated falciparum malaria, anemia, and child growth
    Benno Kreuels
    Infectious Disease Epidemiology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    Blood 115:4551-8. 2010
    ..is known about the effect of HbS and especially HbC on Plasmodium falciparum infection, uncomplicated malaria, and anemia. A total of 1070 children from the Ashanti Region, Ghana, were enrolled at the age of 3 months and visited monthly ..
  61. ncbi Sotatercept, a soluble activin receptor type 2A IgG-Fc fusion protein for the treatment of anemia and bone loss
    Noopur Raje
    Harvard Medical School, Massachusetts General Hospital Cancer Center, Division of Hematology Oncology, PO Box 216, 55 Fruit Street, Boston, MA 02114, USA
    Curr Opin Mol Ther 12:586-97. 2010
    ..At the time of publication, phase II trials in patients with anemia were ongoing...
  62. doi New anemia therapies: translating novel strategies from bench to bedside
    Iain C Macdougall
    Department of Renal Medicine, King s College Hospital, London, United Kingdom
    Am J Kidney Dis 59:444-51. 2012
    Recombinant human erythropoietin (epoetin) has been available for the treatment of renal anemia for more than 20 years, and within the last decade two molecularly engineered analogues darbepoetin alfa and pegylated epoetin beta were ..
  63. doi Erythropoietin, but not the correction of anemia alone, protects from chronic kidney allograft injury
    Paola Cassis
    Transplant Research Center, Chiara Cucchi De Alessandri and Gilberto Crespi Mario Negri Institute for Pharmacological Research, Ranica, Bergamo, Italy
    Kidney Int 81:903-18. 2012
    b>Anemia can contribute to chronic allograft injury by limiting oxygen delivery to tissues, particularly in the tubulointerstitium...
  64. pmc Mechanisms of anemia in CKD
    Jodie L Babitt
    Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA
    J Am Soc Nephrol 23:1631-4. 2012
    b>Anemia is a common feature of CKD associated with poor outcomes...
  65. doi Prevalence of iron, folate, and vitamin B12 deficiency anemia after laparoscopic Roux-en-Y gastric bypass
    Angel G Vargas-Ruiz
    Department of Hematology Oncology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga 15, Tlalpan, 14000, Mexico DF, Mexico
    Obes Surg 18:288-93. 2008
    ..The objective of this study was to evaluate the incidence of iron, folate, and vitamin B12 deficiency anemia in patients undergoing LRYGBP.
  66. doi ITPA polymorphism affects ribavirin-induced anemia and outcomes of therapy--a genome-wide study of Japanese HCV virus patients
    Hidenori Ochi
    Laboratory for Liver Diseases, RIKEN Center for Genomic Medicine, Hiroshima, Japan
    Gastroenterology 139:1190-7. 2010
    Ribavirin-induced anemia is one of the major causes of discontinuation and dose reduction during anti-hepatitis C virus therapy. Factors influencing this anemia, especially host genetic factors, are poorly understood...
  67. doi Down-regulation of hepcidin resulting from long-term treatment with an anti-IL-6 receptor antibody (tocilizumab) improves anemia of inflammation in multicentric Castleman disease
    Soken Nakazawa J Song
    Center for Advanced Science and Innovation, Osaka University, 2 1 Yamada oka, Suita, Osaka, Japan
    Blood 116:3627-34. 2010
    Dysregulated production of hepcidin is implicated in anemia of inflammation, whereas interleukin-6 (IL-6) is a major inducer of hepcidin production...
  68. pmc The age patterns of severe malaria syndromes in sub-Saharan Africa across a range of transmission intensities and seasonality settings
    Arantxa Roca-Feltrer
    Department of Disease Control, Faculty of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    Malar J 9:282. 2010
    ..A greater understanding of the relationship between transmission intensity, seasonality and the age-pattern of malaria is needed to guide appropriate targeting of malaria interventions in different epidemiological settings...
  69. ncbi Hypoxia and anemia: factors in decreased sensitivity to radiation therapy and chemotherapy?
    Louis Harrison
    Department of Radiation Oncology, Beth Israel Medical Center, St Lukes Roosevelt Hospital Center, 10 Union Square East, New York, NY 10003 3314, USA
    Oncologist 9:31-40. 2004
    Hypoxia is a common feature of solid tumors that occurs across a wide variety of malignancies. Hypoxia and anemia (which contributes to tumor hypoxia) can lead to ionizing radiation and chemotherapy resistance by depriving tumor cells of ..
  70. doi Anemia and mortality in heart failure patients a systematic review and meta-analysis
    Hessel F Groenveld
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    J Am Coll Cardiol 52:818-27. 2008
    The aim of this study was to assess the effect of anemia on mortality in chronic heart failure (CHF).
  71. doi Erythroid-stimulating agents in cancer therapy: potential dangers and biologic mechanisms
    Brandon K Hadland
    Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA
    J Clin Oncol 27:4217-26. 2009
    ..agents (ESAs) were originally designed to replace endogenous erythropoietin in patients with anemia secondary to renal failure...
  72. doi Anemia--still a major health problem in many parts of the world!
    Nils Milman
    Department of Clinical Biochemistry, Naestved Hospital, Ringstedgade 61, 4700, Naestved, Denmark
    Ann Hematol 90:369-77. 2011
    b>Anemia is a major global health problem, especially in developing countries...
  73. doi Prevalence of anemia and micronutrient deficiencies in early pregnancy in rural Bangladesh, the MINIMat trial
    Emma Lindström
    International Maternal and Child Health, Department of Women s and Children s Health, Uppsala University, Sweden
    Acta Obstet Gynecol Scand 90:47-56. 2011
    To describe the prevalence of anemia and micronutrient deficiencies as well as their determinants in early pregnancy.
  74. pmc Concurrent helminthic infection protects schoolchildren with Plasmodium vivax from anemia
    Gisely Cardoso Melo
    University of the State of Amazonas, Manaus, Amazonas, Brazil
    PLoS ONE 5:e11206. 2010
    ....
  75. doi Disordered iron homeostasis in chronic heart failure: prevalence, predictors, and relation to anemia, exercise capacity, and survival
    Darlington O Okonko
    Clinical Cardiology, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    J Am Coll Cardiol 58:1241-51. 2011
    ..The aim of this study was to comprehensively delineate iron metabolism and its implications in patients with chronic heart failure (CHF)...
  76. doi Circulating unmetabolized folic acid and 5-methyltetrahydrofolate in relation to anemia, macrocytosis, and cognitive test performance in American seniors
    Martha Savaria Morris
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 91:1733-44. 2010
    ..However, clinical consequences of vitamin B-12 deficiency may be worsened by high folic acid intakes, perhaps as a direct result of unmetabolized folic acid, which does not occur naturally in body tissues...
  77. ncbi Epidemiology of anemia in human immunodeficiency virus (HIV)-infected persons: results from the multistate adult and adolescent spectrum of HIV disease surveillance project
    P S Sullivan
    Division of HIV AIDS Prevention, National Center for HIV, STD, and TB Prevention, Atlanta, Georgia, USA
    Blood 91:301-8. 1998
    To study the incidence of, the factors associated with, and the effect on survival of anemia in human immunodeficiency virus (HIV)-infected persons, we analyzed data from the longitudinal medical record reviews of 32,867 HIV-infected ..
  78. ncbi Liver cell death and anemia in Wilson disease involve acid sphingomyelinase and ceramide
    Philipp A Lang
    Institute of Physiology University of Tübingen, 72076 Tubingen, Germany
    Nat Med 13:164-70. 2007
    Wilson disease is caused by accumulation of Cu(2+) in cells, which results in liver cirrhosis and, occasionally, anemia. Here, we show that Cu(2+) triggers hepatocyte apoptosis through activation of acid sphingomyelinase (Asm) and release ..
  79. pmc Anemia and splenomegaly in cGKI-deficient mice
    Michael Foller
    Department of Physiology, Interfakultäres Institut für Biochemie, University of Tubingen, D72076 Tübingen, Germany
    Proc Natl Acad Sci U S A 105:6771-6. 2008
    ..By the age of 10 weeks, cGKI-deficient mice exhibited pronounced anemia and splenomegaly...
  80. doi A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease
    Marc A Pfeffer
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 361:2019-32. 2009
    b>Anemia is associated with an increased risk of cardiovascular and renal events among patients with type 2 diabetes and chronic kidney disease...
  81. ncbi Anemia is associated with worse symptoms, greater impairment in functional capacity and a significant increase in mortality in patients with advanced heart failure
    Tamara B Horwich
    Department of Medicine, Division of Cardiology, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095 1679, USA
    J Am Coll Cardiol 39:1780-6. 2002
    This study aimed to evaluate the relationship between anemia and heart failure (HF) prognosis.
  82. ncbi Double-blind comparison of full and partial anemia correction in incident hemodialysis patients without symptomatic heart disease
    Patrick S Parfrey
    Division of Nephrology, Health Sciences Center, Memorial University of Newfoundland, Prince Philip Drive, St John s, Newfoundland A1B 3V6, Canada
    J Am Soc Nephrol 16:2180-9. 2005
    ..Normalization of hemoglobin in incident hemodialysis patients does not have a beneficial effect on cardiac structure, compared with partial correction...
  83. ncbi Impact of malaria control on childhood anaemia in Africa -- a quantitative review
    Eline L Korenromp
    World Health Organization, Roll Back Malaria, Geneva, Switzerland
    Trop Med Int Health 9:1050-65. 2004
    ..To review the impact of malaria control on haemoglobin (Hb) distributions and anaemia prevalences in children under 5 in malaria-endemic Africa...
  84. pmc Helminth infection and cognitive impairment among Filipino children
    Amara E Ezeamama
    International Health Institute, Brown University, Providence, Rhode Island 02912, USA
    Am J Trop Med Hyg 72:540-8. 2005
    ..04-30). Helminth infection was associated with lower performance in three of the four cognitive domains examined in this study. These relationships remained after rigorous control for other helminths and important confounding covariates...
  85. ncbi Normalization of hemoglobin level in patients with chronic kidney disease and anemia
    Tilman B Drueke
    Inserm Unité 507 and Assistance Publique Hôpitaux de Paris, Necker Hospital, Division of Nephrology, Paris, France
    N Engl J Med 355:2071-84. 2006
    Whether correction of anemia in patients with stage 3 or 4 chronic kidney disease improves cardiovascular outcomes is not established.
  86. ncbi Malarial anemia: of mice and men
    Abigail A Lamikanra
    Nuffield Department of Clinical Laboratory Sciences and National Blood Service Oxford Centre, John Radcliffe Hospital, Oxford, United Kingdom
    Blood 110:18-28. 2007
    ..In young infants, severe malarial anemia (SMA) is the most common syndrome of severe disease and contributes substantially to the considerable mortality ..
  87. ncbi Intravenous ferric carboxymaltose compared with oral iron in the treatment of postpartum anemia: a randomized controlled trial
    David B Van Wyck
    Arizona Health Sciences Center, University of Arizona College of Medicine, 1821 East Elm Street, Tucson, AZ 85719, USA
    Obstet Gynecol 110:267-78. 2007
    ..To estimate efficacy of rapid, large-dose intravenous (IV) administration of ferric carboxymaltose compared with oral iron therapy in anemic postpartum women...
  88. ncbi Severe malaria in children in areas with low, moderate and high transmission intensity in Uganda
    R Idro
    Department of Paediatrics and Child Health, Mulago Hospital Makerere University Medical School, Kampala, Uganda
    Trop Med Int Health 11:115-24. 2006
    ....
  89. ncbi Intravenous iron alone for the treatment of anemia in patients with chronic heart failure
    Aidan P Bolger
    Department of Clinical Cardiology, The Heart Hospital, London, United Kingdom
    J Am Coll Cardiol 48:1225-7. 2006
    This study was undertaken to assess the hematologic, clinical, and biochemical response to intravenous iron in patients with chronic heart failure (CHF) and anemia.
  90. ncbi Cre activity causes widespread apoptosis and lethal anemia during embryonic development
    L A Naiche
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Genesis 45:768-75. 2007
    ..This information will be critical in both evaluating previously published work using cre alleles and in designing future experiments...
  91. pmc The effect of timing and frequency of Plasmodium falciparum infection during pregnancy on the risk of low birth weight and maternal anemia
    Linda Kalilani
    University of Malawi, College of Medicine, Blantyre, Malawi
    Trans R Soc Trop Med Hyg 104:416-22. 2010
    Plasmodium falciparum infection during pregnancy causes maternal anemia and low birth weight (LBW), but the effect of frequency and timing of infection on the severity of these adverse effects is unknown...
  92. doi Inhibition of erythropoiesis in malaria anemia: role of hemozoin and hemozoin-generated 4-hydroxynonenal
    Oleksii A Skorokhod
    Department of Genetics, Biology, and Biochemistry, Laboratory of Cell Therapy, University of Torino Medical School, Torino, Italy
    Blood 116:4328-37. 2010
    Severe malaria anemia is characterized by inhibited/altered erythropoiesis and presence of hemozoin-(HZ)-laden bone-marrow macrophages...
  93. pmc Improving educational achievement and anaemia of school children: design of a cluster randomised trial of school-based malaria prevention and enhanced literacy instruction in Kenya
    Simon Brooker
    Malaria Public Health and Epidemiology Group, Kenya Medical Research Institute Wellcome Trust Research Programme, Nairobi, Kenya
    Trials 11:93. 2010
    ..This study aims to evaluate the impact of school-based malaria prevention and enhanced literacy instruction on the health and educational achievement of school children in Kenya...
  94. ncbi The role of hepcidin in iron sequestration during infections and in the pathogenesis of anemia of chronic disease
    Tomas Ganz
    Departments of Medicine and Pathology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Isr Med Assoc J 4:1043-5. 2002
    ..to invading pathogens and may inhibit their multiplication and other metabolic processes but also results in anemia of chronic disease...
  95. ncbi Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia
    Jack M Guralnik
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, 7201 Wisconsin Ave, Rm 3C 309, Bethesda, MD 20815, USA
    Blood 104:2263-8. 2004
    Clinicians frequently identify anemia in their older patients, but national data on the prevalence and causes of anemia in this population in the United States have been unavailable...
  96. ncbi Anemia, tumor hypoxemia, and the cancer patient
    John Varlotto
    Department of Radiation Oncology, Boston VA Medical Center, Boston, MA 02130, USA
    Int J Radiat Oncol Biol Phys 63:25-36. 2005
    To review the impact of anemia/tumor hypoxemia on the quality of life and survival in cancer patients, and to assess the problems associated with the correction of this difficulty.
  97. pmc Association of anemia and erythropoiesis stimulating agents with inflammatory biomarkers in chronic kidney disease
    Sai Ram Keithi-Reddy
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Kidney Int 74:782-90. 2008
    ..Here we explored the relationship of anemia and epoetin treatment to inflammatory cytokine levels in patients with chronic kidney disease...
  98. ncbi Geophagy (Soil-eating) in relation to Anemia and Helminth infection among HIV-infected pregnant women in Tanzania
    Kosuke Kawai
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Trop Med Hyg 80:36-43. 2009
    ..We examined the associations of geophagy with anemia and helminth infection among 971 human immunodeficiency virus (HIV)-positive pregnant women in Tanzania...
  99. doi Prolyl hydroxylase domain-containing protein inhibitors as stabilizers of hypoxia-inducible factor: small molecule-based therapeutics for anemia
    Lin Yan
    Department of Medicinal Chemistry, Merck Research Laboratories, P O Box 2000, Rahway, NJ 07065, USA
    Expert Opin Ther Pat 20:1219-45. 2010
    b>Anemia caused by chronic kidney disease and other chronic diseases or conditions can be managed by the treatment of biologic-based erythropoiesis stimulating agents (ESAs)...
  100. pmc Hemophagocytosis causes a consumptive anemia of inflammation
    Erin E Zoller
    Division of Immunobiology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
    J Exp Med 208:1203-14. 2011
    ..We report that interferon γ (IFN-γ) is a critical driver of the acute anemia observed during diverse microbial infections in mice...
  101. pmc Mapping the risk of anaemia in preschool-age children: the contribution of malnutrition, malaria, and helminth infections in West Africa
    Ricardo J Soares Magalhães
    School of Population Health, University of Queensland, Herston, Queensland, Australia
    PLoS Med 8:e1000438. 2011
    ....

Research Grants85

  1. Intestinal Iron Transport in Iron Deficiency/Anemia
    James Collins; Fiscal Year: 2005
    ..genes, only the genes encoding the brush-border membrane proteins dcytb and DMT1 were consistently induced in anemia, while other genes involved in iron export from enterocytes such as ferroportin and hephaestin did not show ..
  2. Robert T Means; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): The anemia of chronic disease (ACD) is one of the most common clinical syndromes encountered in the practice of medicine...
  3. Donald A McClain; Fiscal Year: 2016
    ..of hepatic glucose production in mice fed dietary iron within the low and high ranges of normal, wherein neither anemia nor overt iron overloads result...
  4. Hepcidin-based screening for infantile iron deficiency
    Mark D Fleming; Fiscal Year: 2010
    ..Iron deficiency anemia (IDA) affects nearly 3% of children in the U.S. aged 1-2 years...
  5. Role of the Mammalian Siderophore in Cellular Iron Metabolism and Erythropoiesis
    Laxminarayana R Devireddy; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Iron deficiency anemia is the most common form of anemia affects about one in five women, half of pregnant women, 3 percent of men in the ..
  6. Jianming Qiu; Fiscal Year: 2016
    ..diseases, including transient aplastic crisis in patients with a high turn-over rate f red blood cells;and chronic anemia in immunodeficient and immunocompromised patients which, in some cases, can be fatal...
  7. Twenty-second Annual Fanconi Anemia Research Fund Scientific Symposium
    GROVER CARLTON BAGBY; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Twenty-second Annual Fanconi Anemia Research Fund Scientific Symposium Fanconi anemia (FA) is a rare hereditary disease characterized by bone marrow failure, developmental anomalies, a high incidence ..
  8. 24th Annual Fanconi Anemia Research Fund Scientific Symposium
    GROVER CARLTON BAGBY; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Fanconi anemia (FA) is a rare hereditary disease characterized by bone marrow failure, developmental anomalies, high incidence of myelodysplasia (MDS), acute non-lymphocytic leukemia (AML), solid ..
  9. Mechanisms of Endothelin 1-Induced Sickle Cell Pathology
    Alicia Rivera; Fiscal Year: 2011
    ..It is characterized by red blood cell hemolysis, chronic anemia, and recurrent episodic pain...
  10. Mechanisms of Heme Transport in Macrophages
    CARINE CARINE WHITE; Fiscal Year: 2012
    ..In zebrafish, knockdown of hrg-1 results in yolk tube defects, hydrocephalus, and severe anemia;and these defects are fully rescued by worm HRG-1...
  11. Impacts of surface receptors [Toll like receptor (TLRs) and Fc gamma receptors (F
    Collins Ouma; Fiscal Year: 2012
    ..Toll like receptors (TLRs) and Fc gamma receptors (Fc3R)] in susceptibility to pediatric severe malarial anemia Severe malarial anemia (SMA) is the most common clinical manifestation of severe malaria in infants and young ..
  12. Mouse models of genomic instability and birth defects
    CATHERINE ELIZABETH KEEGAN; Fiscal Year: 2013
    ..defects have been reported in other genetic syndromes characterized by genomic instability, including Fanconi anemia and Rothmund-Thomson syndrome;however, the mechanisms that lead to birth defects in these syndromes are unknown...
  13. PEARLIE K BURNETTE; Fiscal Year: 2016
    ..Several syndromes of T cell-mediated bone marrow failure have similar pathology including aplastic anemia (AA), paroxysmal nocturnal hemaglobinuria (PNH), and a subset of patients with Myelodysplastic Syndrome (MDS)...
  14. Molecular Biology of Human Erythrocyte Alpha Spectrin
    Patrick G Gallagher; Fiscal Year: 2013
    ..Abnormalities of ?-spectrin are associated with inherited hemolytic anemia, which is sometimes severe...
  15. Enrico M Novelli; Fiscal Year: 2016
    ..in the Tenure Stream in the Department of Medicine and Director of the University of Pittsburgh Adult Sickle Cell Anemia Program. Dr...
  16. IRON REGULATION OF GENE EXPRESSION
    ELIZABETH ANN LEIBOLD; Fiscal Year: 2013
    ..iron deficiency perinatally or postnatally can cause neurocognitive impairment, and deficiency in adults cause anemia. All organisms have therefore developed mechanisms to sense, acquire and store iron...
  17. Role of murine induced pluripotent stem cells on the correction of cardiac and sk
    Diego Fraidenraich; Fiscal Year: 2010
    ..In addition, a recent proof-of-principle experiment showed that iPS cells can correct disease (sickle cell anemia) in mice...
  18. Haoxing Xu; Fiscal Year: 2016
    ..ML4 patients exhibit motor defects, mental retardation, retinal degeneration, and iron-deficiency anemia. Mice with mutations in TRPML3 (the varitint-waddler, Va mice) are deaf and exhibit circling behavior and ..
  19. New drug Vida-5 for treating chronic kidney disease progression
    Jinshyun Ruth Wu-Wong; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Twenty-six million people in America have chronic kidney disease (CKD). Anemia, cardiovascular diseases, secondary hyperparathyroidism, renal osteodystrophy and other complications are common in CKD...
  20. Development of a Pediatric Mylelodysplastic Syndrome Patient Registry
    DAVID A contact WILLIAMS; Fiscal Year: 2010
    ..elderly, certain genetic conditions such as inherited bone marrow failure syndromes, as well as acquired aplastic anemia and MDS in a first-degree relative predispose young patients to MDS...
  21. Mechanistic Characterization and Genetic Analysis of Systemic Iron Homeostasis
    Xin Du; Fiscal Year: 2011
    ..Iron deficiency afflicts 30% of the world's population, and can cause anemia, developmental retardation, fertility problems and immune dysfunction. However, iron is a double-edged sword...
  22. KATHERINE YUDEH KING; Fiscal Year: 2014
    ..to critical information about use of interferons or inhibitors of autophagy as therapeutic agents for aplastic anemia and myelosuppression due to severe viral and mycobacterial infections...
  23. Biological Functions of Iron Responsive Elements
    Richard S Eisenstein; Fiscal Year: 2012
    ..In addition to diet, anemia can be caused by disorders in oxygen sensing pathways associated with renal failure, normal aging, genetic ..
  24. TSAD AS AN EPOR/JAK2 ADAPTOR AND ERYTHROPOIETIC REGULATOR
    DONALD JOSEPH MCCRANN; Fiscal Year: 2010
    ..EPO is a key regulator of erythroid cell formation in response to hypoxia and anemia. The binding of EPO to its cell surface receptor (EPOR) on pro-erythroblasts activates EPOR/JAK2 kinase complexes...
  25. Regulation of insulator function and globin gene expression by USF and associated
    Suming Huang; Fiscal Year: 2013
    ..Mutations of globin genes are among the most common inherited diseases and cause mild or severe anemia in the human population...
  26. Erythropoietin in Non-Erythroid Cells: Function and Regulation
    Josef T Prchal; Fiscal Year: 2013
    ..Recombinant human Epo has been widely used to correct the anemia of renal failure as well as other types of anemias...
  27. VEGF Regulation of Hepatic Erythropoietin Synthesis
    Calvin Kuo; Fiscal Year: 2009
    ..Either insufficient or excess erythropoiesis produces disease in humans, with too few RBCs resulting in anemia, and too many RBCs resulting in polycythemia vera...
  28. Rheologic and Vascular Modulators in Sickle Vaso-occlusion
    Dhananjay K Kaul; Fiscal Year: 2012
    ..Chronic hypoxia is a predictable consequence of abnormal red cell rheology, sickling, hemolytic anemia and recurring vaso-occlusive episodes...
  29. Non-viral gene therapy for sickle cell anemia
    CLIFFORD JOHN STEER; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Sickle cell anemia (SCA) is one of the most common inherited hematological diseases, and caused by a single amino acid substitution in the 2-globin chain of hemoglobin (Hb)...
  30. Novel therapies for Fanconi anemia
    DAVID A contact WILLIAMS; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Fanconi anemia (FA) is a rare recessive syndrome characterized by bone marrow failure, congenital anomalies and a predisposition to malignancy...
  31. Twenty-first Annual Fanconi Anemia Research Fund Scientific Symposium
    Grover Bagby; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Twenty-first Annual Fanconi Anemia Research Fund Scientific Symposium...
  32. Yelena Ginzburg; Fiscal Year: 2015
    ..Beta-thalassemia in humans is a disease associated with anemia, splenomegaly, and ineffective erythropoiesis;iron overload in this disease results from transfusion and increased ..
  33. Ribosomal Protein Gene Silencing in Neural Crest Stem Cells
    JOHNSON MING YU LIU; Fiscal Year: 2010
    Diamond Blackfan anemia (DBA) is one of a class of disorders linked to defects in ribosome biogenesis. While classified as a bone marrow failure syndrome, some DBA patients exhibit craniofacial anomalies...
  34. Punam Malik; Fiscal Year: 2016
    Project Summary Pulmonary hypertension (PHT) occurs in ~30% of patients with sickle cell anemia (SCA) and results in ~50% mortality within 2 years of diagnosis...
  35. The Role of PKR in a Novel IL-3 Signal Transduction Pathway
    William Stratford May; Fiscal Year: 2012
    ..levels of activated PKR associated with aberrant apoptosis of bone marrow progenitor cells, such as in Fanconi anemia (FA) and Myelodysplastic Syndrome (MDS) that progress to AML...
  36. Michael K Georgieff; Fiscal Year: 2015
    ..In humans and dietary ID anemia (IDA) animal models, it is unclear whether structural and behavioral effects in the developing brain are due ..
  37. Chandy C John; Fiscal Year: 2016
    ..children with CM in 2 age groups (18 mo-4 years, 5-12 years) to healthy children and children with severe malarial anemia in these age groups, at discharge and in follow-up...
  38. New Investigation Initiatives for the Prevention of Complications of Thalassemia
    Ellis J Neufeld; Fiscal Year: 2011
    ..of this project is to improve care and long-term health outcomes in patients with Thalassemia (Cooley's Anemia)...
  39. The Transcobalamin Receptor in Cobalamin Homeostasis
    Edward V Quadros; Fiscal Year: 2011
    Vitamin B12 (cobalamin, Cbl) deficiency in humans produces megaloblastic anemia and neuropathologic disorders. Cbl requirement for the methionine synthase enzyme in the recycling of folate results in defective DNA synthesis and the anemia...
  40. Francis Perry Wilson; Fiscal Year: 2016
    ..b>Anemia, acidosis, decreased protein intake, and decreased physical activity may associate with greater declines in muscle ..
  41. Studying a Human Stem Cell Disease Using iPS Technology
    Steven E Artandi; Fiscal Year: 2010
    ..Aplastic anemia in patients with DC is accompanied by defects in other tissues, including oral mucosa, nails and lung, among other ..
  42. Functional analysis of mDia formins in hematopoietic stem cell engraftment and mi
    Peng Ji; Fiscal Year: 2010
    ..has become a routine clinical strategy for treating patients with many blood related diseases such as aplastic anemia, fanconi anemia, sickle cell anemia, beta thalassemia major, leukemia, lymphomas, multiple myeloma, and many ..
  43. Celiac Disease: From Genetic Risk to Disease Development
    Susan L Neuhausen; Fiscal Year: 2009
    ..Some complications of CD include lymphoma, osteoporosis, anemia, miscarriages, seizures, vitamin deficiencies, and co-occurrence of other autoimmune diseases...
  44. Transplantation tolerance and immune function following mTOR inhibition.
    Jonathan D Powell; Fiscal Year: 2013
    ..offers a safe, potentially curative treatment for non-malignant hematological diseases such as sickle cell anemia. Unfortunately, successful nonmyeloablative transplant to treat sickle cell anemia has been limited due to immune-..
  45. Gary M Brittenham; Fiscal Year: 2014
    ..anemias that are themselves orphan disorders, including sickle-cell disease, thalassemia major (Cooley's anemia), Diamond-Blackfan anemia, aplastic anemia, pure red cell aplasia, hypoplastic and myelodysplastic disorders...
  46. SIGNAL TRANSDUCTION MECHANISMS OF ERYTHROPOIETIN
    Barbara A Miller; Fiscal Year: 2011
    ..in understanding and treating disease of decreased red cell production secondary to many causes including anemia of chronic renal failure, as well as diseases of overproduction such as polycythemia or erythroleukemia...
  47. Sheila Gahagan; Fiscal Year: 2016
    ..as part of a NIH-supported cohort study of the behavioral and developmental effects of preventing iron deficiency anemia in infancy (n = 1645)...
  48. Qishen Pang; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): This proposal will investigate the mechanisms by which Fanconi anemia (FA) proteins regulate cellular response to oxidative stress in the context of hematopoiesis...
  49. Mac-1 (CR3) and Fc gamma receptors in immune-mediated neutrophil cytotoxicity
    Tanya N Mayadas; Fiscal Year: 2013
    ..role of Vav and Rac in IgG or complement mediated phagocytosis in macrophages in models of autoimmune hemolytic anemia. We anticipate that the completion of our aims should lead to a better understanding of signaling pathways that ..
  50. Jaroslaw P Maciejewski; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Bone marrow failure (BMF) syndromes, including aplastic anemia (AA) and myelodysplasia (MDS) are disorders characterized by hematopoietic progenitor or stem cell failure resulting in deficient ..
  51. Hematopoietic Cell Transplantation and Iron Overload
    H Joachim Deeg; Fiscal Year: 2013
    ..Contributing pre-transplant causes include enhanced intestinal iron absorption secondary to anemia, and red blood cell transfusions...
  52. Nancy Berliner; Fiscal Year: 2015
    ..3:1 ratio), which have anti- inflammatory properties, on erythropoietic cell signaling and the development of anemia in the elderly in the setting of the newly launched VITamin D and OmegA-3 TriaL (VITAL)...
  53. Richard S Eisenstein; Fiscal Year: 2016
    ..In addition to diet, anemia can be caused by disorders in oxygen sensing pathways associated with renal failure, normal aging, genetic ..
  54. Effect of Diet on Inflammation in Sicke Cell Mice
    Jacqueline M Hibbert; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Characteristic chronic hemolysis in sickle cell anemia is presumed to induce an inflammatory response through sub-clinical vasooclusion...
  55. Novel Erythroid Cell Membrane Protein
    Emery H Bresnick; Fiscal Year: 2010
    While erythropoietin (Epo) is commonly used to treat anemia in patients with cancer and kidney disease, recent studies have raised major safety concerns...
  56. Globin Gene Expression during Erythroid Differentiation
    Gordon D Ginder; Fiscal Year: 2010
    ..targets for safe therapeutic activation of fetal/embryonic globin gene expression in ?-thalassemia and sickle cell anemia. This objective will be pursued through the following specific aims: 1) To characterize the protein components of ..
  57. MELINDA SUE BUTSCHKOVACIC; Fiscal Year: 2015
    ..of and host immunological responses to human papillomavirus (HPV) infection in individuals with Fanconi anemia (FA) and their families...
  58. Lopa Mishra; Fiscal Year: 2016
    ..damage that is exacerbated by DNA cross-linking agents such as mitomycin C similar to P57 null cells and Fanconi anemia cell lines...
  59. BENJAMIN LEVINE EBERT; Fiscal Year: 2016
    ..by ineffective hematopoiesis, most commonly of the erythroid lineage, resulting in a phenotype termed refractory anemia. In the 5q- syndrome, a subtype of MDS, a single genetic lesion, a heterozygous, interstitial deletion of ..
  60. Therapeutic Value of Fish Oil Rx on SLE and Bone Loss in Mice
    GABRIEL J J FERNANDES; Fiscal Year: 2012
    ..Its clinical features include glomerulonephritis, cardiovascular disease (CVD), skin rashes, serositis, hemolytic anemia, impairment of the central nervous system and bone loss...
  61. Identification of a Molecular Signature for Barrier Insulators
    LAURIE ANN STEINER; Fiscal Year: 2013
    ..In addition, mutations disrupting barrier insulator function have been linked to inherited hemolytic anemia. The mechanisms underlying these aberrations in gene expression are unclear, because little is known about the ..
  62. The influenza A virus nucleoprotein: structure and function
    Yizhi Jane Tao; Fiscal Year: 2012
    ..of specific sites of NP on its various functions;and (5) solve the structure of NP from infectious salmon anemia virus (ISAV) and influenza B virus and determine whether NP self-oligomerization and RNA binding modes are broadly ..
  63. BENJAMIN BRAUN; Fiscal Year: 2016
    ..This is characterized by profound myelomonocytic proliferation, severe anemia, early death and complete penetrance...
  64. A Comparative Approach to Globin Regulation/Thalassemia
    LEONARD IRA ZON; Fiscal Year: 2012
    ..Our analysis of mutant fish with a hypochromic microcytic anemia has provided key insights into factors that regulate hemoglobin synthesis...
  65. Fc receptor targeted therapy for immune hemolytic anemia
    Periasamy Selvaraj; Fiscal Year: 2009
    ..Principal Investigator/Program Director (Last, first, middle): Selvaraj, Periasamy Abstract: Autoimmune hemolytic anemia (AIHA) is caused by the destruction of autoantibody-coated RBCs by phagocytes...
  66. SURGICAL TREATMENTS OUTCOMES PROJECT FOR DUB (STOP-DUB)
    Kay Dickersin; Fiscal Year: 2000
    ..Consequences of DUB include discomfort, fatigue, limitation of activity, impaired sexual function, depression, and anemia. Estimates of prevalence for menorrhagia range from 9-20% of women, and metrorrhagia occurs in 53 women per 1,000...
  67. Vitamin B12 and Folate in Relation to Cognition in the Framingham Offspring Study
    Jacob Selhub; Fiscal Year: 2010
    ..Concern arose from a few historic case reports suggesting the masking of anemia and worsening of neuropsychiatric symptoms in pernicious anemia (PA) patients mistakenly treated with folic acid...
  68. Novel Molecular and Cellular Therapies in Fanconi Anemia
    David Williams; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Fanconi anemia (FA) is a recessive disease characterized by nearly universal progressive bone marrow failure and a constellation of serious physical anomalies...
  69. MicroRNAs Regulating The Fanconi Anemia-BRCA Pathway
    Toshiyasu Taniguchi; Fiscal Year: 2009
    ..Resistance to these drugs is a major problem for effective cancer therapy. Fanconi anemia is a genetic disorder characterized by aplastic anemia, cancer/leukemia susceptibility and hypersensitivity to DNA-..
  70. Towards a Model of Fanconi Anemia
    BEVERLY JO TOROK STORB; Fiscal Year: 2010
    ..of human disease, mouse models have not accurately reflected the spectrum of disease in conditions such as Fanconi anemia. There are currently no large animal systems whose genomes can be readily manipulated...
  71. IRON DEFICIENCY ANEMIA AND COMPENSATORY SNS ACTIVITY
    John Beard; Fiscal Year: 1991
    ..Elevated plasma and urine norepinephrine (NE) levels are unaffected by this correction of anemia. Accurate data on metabolic rate, tissue NE turnover, thyroid hormone metabolism or actual thermogenic activity ..
  72. Hemolytic Anemia: Biochemical, Molecular and Proteomic Diagnostics
    Jeffrey S Friedman; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Hemolytic Anemia: Biochemical, Molecular and Proteomic Diagnostics The hereditary hemolytic anemias, comprising both enzyme deficiencies and red cell membrane protein defects are a heterogeneous group ..
  73. Ribosome Biogenesis in Diamond Blackfan Anemia
    Monica Bessler; Fiscal Year: 2007
    ..Here we propose to newly investigate the mechanisms that lead to Diamond Blackfan Anemia (DBA) a rare bone marrow failure syndrome presenting mainly in early infancy...
  74. Individualized Treatment Strategies and Optimal Hematocrit Target for Complex Dia
    DENNIS JOSEPH COTTER; Fiscal Year: 2010
    ..Almost all renal failure patients suffer from anemia as an important co- morbid condition...
  75. ORAL L GLUTAMINE THERAPY FOR SICKLE CELL ANEMIA
    Yutaka Niihara; Fiscal Year: 2001
    DESCRIPTION: Sickle cell anemia is one of the most common and devastating hereditary disorders with significant morbidity and mortality affecting individuals of African American heritage. No safe, effective therapy is yet available...
  76. DRUG ETIOLOGY OF APLASTIC ANEMIA AND RELATED DYSCRASIAS
    David Kaufman; Fiscal Year: 1991
    ..evaluate the role of drugs (other than those used for chemotherapy and immunotherapy) in the etiology of aplastic anemia, agranulocytosis, and thrombocytopenic purpura will be continued...
  77. Symposium: Progress in Fanconi Anemia Research
    Grover Bagby; Fiscal Year: 2001
    Fanconi anemia (FA) is an autosomal recessive disease characterized by bone marrow (BM) failure, variable congenital anomalies, and a predisposition to leukemia...