spontaneous abortion

Summary

Summary: Expulsion of the product of FERTILIZATION before completing the term of GESTATION and without deliberate interference.

Top Publications

  1. ncbi Decidual and peripheral blood CD4+CD25+ regulatory T cells in early pregnancy subjects and spontaneous abortion cases
    Y Sasaki
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama shi, Toyama, 930 0194, Japan
    Mol Hum Reprod 10:347-53. 2004
  2. ncbi Arsenic exposure in pregnant mice disrupts placental vasculogenesis and causes spontaneous abortion
    Wenjie He
    Department of Biomedical and Pharmaceutical Sciences and Center for Environmental Health Sciences, The University of Montana, Missoula, Montana 59812, USA
    Toxicol Sci 99:244-53. 2007
  3. ncbi The evidence that lead increases the risk for spontaneous abortion
    I Hertz-Picciotto
    University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Am J Ind Med 38:300-9. 2000
  4. pmc Abnormal T-cell reactivity against paternal antigens in spontaneous abortion: adoptive transfer of pregnancy-induced CD4+CD25+ T regulatory cells prevents fetal rejection in a murine abortion model
    Ana Claudia Zenclussen
    Institut fur Medizinische Immunologie, Biomedizinisches Forschungszentrum, Raum 2 0534, Charite, Campus Virchow Klinikum, Augustenburger Platz 1, D 13353, Berlin, Germany
    Am J Pathol 166:811-22. 2005
  5. pmc Complete genome sequence and lifestyle of black-pigmented Corynebacterium aurimucosum ATCC 700975 (formerly C. nigricans CN-1) isolated from a vaginal swab of a woman with spontaneous abortion
    Eva Trost
    Institut für Genomforschung und Systembiologie, Centrum für Biotechnologie, Universitat Bielefeld, Universitätsstrasse 27, D 33615 Bielefeld, Germany
    BMC Genomics 11:91. 2010
  6. ncbi Causes for spontaneous abortion: what the bugs 'gut' to do with it?
    Astrid Friebe
    Charite, University Medicine, Berlin, Germany
    Int J Biochem Cell Biol 40:2348-52. 2008
  7. ncbi Management of spontaneous abortion
    Craig P Griebel
    Department of Family and Community Medicine, University of Illinois College of Medicine at Peoria, 61602, USA
    Am Fam Physician 72:1243-50. 2005
  8. pmc Drinking water contaminants and adverse pregnancy outcomes: a review
    Frank Bove
    Division of Health Studies, Agency for Toxic Substances and Disease Registry, Atlanta, Georgia, USA
    Environ Health Perspect 110:61-74. 2002
  9. pmc Subfertility and risk of spontaneous abortion
    R H Gray
    School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Am J Public Health 90:1452-4. 2000
  10. pmc Use of antidepressants during pregnancy and the risk of spontaneous abortion
    Hamid Reza Nakhai-Pour
    Faculty of Pharmacy, University of Montreal, Montreal, Que, Canada
    CMAJ 182:1031-7. 2010

Detail Information

Publications282 found, 100 shown here

  1. ncbi Decidual and peripheral blood CD4+CD25+ regulatory T cells in early pregnancy subjects and spontaneous abortion cases
    Y Sasaki
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama shi, Toyama, 930 0194, Japan
    Mol Hum Reprod 10:347-53. 2004
    ..The proportion of decidual CD4(+)CD25(bright) T cells was significantly lower in specimens from spontaneous abortion compared to those from specimens from induced abortions...
  2. ncbi Arsenic exposure in pregnant mice disrupts placental vasculogenesis and causes spontaneous abortion
    Wenjie He
    Department of Biomedical and Pharmaceutical Sciences and Center for Environmental Health Sciences, The University of Montana, Missoula, Montana 59812, USA
    Toxicol Sci 99:244-53. 2007
    ..dysmorphogenesis and defective placental vasculogenesis resulting in placental insufficiency and subsequent spontaneous abortion. To test this hypothesis, pregnant mice were exposed to sodium arsenite (AsIII) through drinking water from ..
  3. ncbi The evidence that lead increases the risk for spontaneous abortion
    I Hertz-Picciotto
    University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Am J Ind Med 38:300-9. 2000
    ..Nevertheless, most studies conducted among populations with low/moderate exposures have provided little evidence of an association with pregnancy loss, or in particular, spontaneous abortions...
  4. pmc Abnormal T-cell reactivity against paternal antigens in spontaneous abortion: adoptive transfer of pregnancy-induced CD4+CD25+ T regulatory cells prevents fetal rejection in a murine abortion model
    Ana Claudia Zenclussen
    Institut fur Medizinische Immunologie, Biomedizinisches Forschungszentrum, Raum 2 0534, Charite, Campus Virchow Klinikum, Augustenburger Platz 1, D 13353, Berlin, Germany
    Am J Pathol 166:811-22. 2005
    ..whether an inappropriate function of T regulatory (Treg) cells is involved in the pathogenesis of spontaneous abortion. We evaluated spleen and decidual lymphocytes from CBA/J mice undergoing immunological abortion (DBA/2J-..
  5. pmc Complete genome sequence and lifestyle of black-pigmented Corynebacterium aurimucosum ATCC 700975 (formerly C. nigricans CN-1) isolated from a vaginal swab of a woman with spontaneous abortion
    Eva Trost
    Institut für Genomforschung und Systembiologie, Centrum für Biotechnologie, Universitat Bielefeld, Universitätsstrasse 27, D 33615 Bielefeld, Germany
    BMC Genomics 11:91. 2010
    ..nigricans CN-1) was originally isolated from a vaginal swab of a 34-year-old woman who experienced a spontaneous abortion during month six of pregnancy...
  6. ncbi Causes for spontaneous abortion: what the bugs 'gut' to do with it?
    Astrid Friebe
    Charite, University Medicine, Berlin, Germany
    Int J Biochem Cell Biol 40:2348-52. 2008
    ..In turn, intestinal barrier function may be enhanced and mediators of immune tolerance may be restored, i.e. in the context of reproduction...
  7. ncbi Management of spontaneous abortion
    Craig P Griebel
    Department of Family and Community Medicine, University of Illinois College of Medicine at Peoria, 61602, USA
    Am Fam Physician 72:1243-50. 2005
    b>Spontaneous abortion, which is the loss of a pregnancy without outside intervention before 20 weeks' gestation, affects up to 20 percent of recognized pregnancies...
  8. pmc Drinking water contaminants and adverse pregnancy outcomes: a review
    Frank Bove
    Division of Health Studies, Agency for Toxic Substances and Disease Registry, Atlanta, Georgia, USA
    Environ Health Perspect 110:61-74. 2002
    ..Nevertheless, the findings of excess NTDs, oral clefts, cardiac defects, and choanal atresia in studies that evaluated TCE-contaminated drinking water deserve follow-up...
  9. pmc Subfertility and risk of spontaneous abortion
    R H Gray
    School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Am J Public Health 90:1452-4. 2000
    The purpose of this study was to assess the association between subfertility and spontaneous abortion.
  10. pmc Use of antidepressants during pregnancy and the risk of spontaneous abortion
    Hamid Reza Nakhai-Pour
    Faculty of Pharmacy, University of Montreal, Montreal, Que, Canada
    CMAJ 182:1031-7. 2010
    ..Whether such use increases the risk of spontaneous abortion is still being debated...
  11. ncbi Continuing metformin throughout pregnancy in women with polycystic ovary syndrome appears to safely reduce first-trimester spontaneous abortion: a pilot study
    C J Glueck
    The Cholesterol Center, Jewish Hospital, Cincinnati, Ohio 45229, USA
    Fertil Steril 75:46-52. 2001
    To determine whether metformin would safely reduce the rate of first-trimester spontaneous abortion without teratogenicity in 19 women with the polycystic ovary syndrome (PCOS).
  12. pmc An exploratory analysis of the effect of pesticide exposure on the risk of spontaneous abortion in an Ontario farm population
    T E Arbuckle
    Bureau of Reproductive and Child Health, Population and Public Health Branch, Health Canada, Ottawa, Ontario, Canada
    Environ Health Perspect 109:851-7. 2001
    ..This study shows that timing of exposure and restricting analyses to more homogeneous endpoints are important in characterizing the reproductive toxicity of pesticides...
  13. ncbi Cigarette, alcohol, and caffeine consumption: risk factors for spontaneous abortion
    Vibeke Rasch
    Institute of Public Health, Department of Epidemiology, University of Southern Denmark, Denmark
    Acta Obstet Gynecol Scand 82:182-8. 2003
    To study the association between cigarette, alcohol, and caffeine consumption and the occurrence of spontaneous abortion.
  14. ncbi The Th1/Th2 paradigm: still important in pregnancy?
    Gerard Chaouat
    Unité 782 INSERM, 32 rue des Carnets 92141 Clamart, France
    Semin Immunopathol 29:95-113. 2007
    ..In this review, we replace the emergence of the paradigm in its historical context and then emphasises what it does explain and what it no longer account for. A final reappraisal of the paradigm is suggested...
  15. pmc Comparative genomic hybridization-array analysis enhances the detection of aneuploidies and submicroscopic imbalances in spontaneous miscarriages
    Anthony J Schaeffer
    Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Am J Hum Genet 74:1168-74. 2004
    ..This retrospective study demonstrates that the DNA-based CGH-array technology overcomes many of the limitations of routine cytogenetic analysis of POC samples while enhancing the detection of fetal chromosome aberrations...
  16. ncbi Expectant, medical or surgical treatment for spontaneous abortion in first trimester of pregnancy: a cost analysis
    Joyce H S You
    Centre for Pharmacoeconomics Research, School of Pharmacy, Department of Obstetrics and Gynaecology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT
    Hum Reprod 20:2873-8. 2005
    ..care have been shown to be acceptable alternatives to routine surgical evacuation for treatment of spontaneous abortion in the first trimester of pregnancy...
  17. ncbi A population-based prospective cohort study of personal exposure to magnetic fields during pregnancy and the risk of miscarriage
    De Kun Li
    Division f Research, Kaiser Foundation Research Institute, Oakland, CA 94611, USA
    Epidemiology 13:9-20. 2002
    ..This observed association is unlikely to be due to uncontrolled biases or unmeasured confounders...
  18. pmc Residential exposure to traffic and spontaneous abortion
    Rochelle S Green
    Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, Oakland, California 94612, USA
    Environ Health Perspect 117:1939-44. 2009
    Studies have shown associations between air pollution or traffic exposure and adverse birth outcomes, such as low birth weight. However, very few studies have examined the effect of traffic emissions on spontaneous abortion (SAB).
  19. pmc Chromosomal abnormalities in spontaneous abortion after assisted reproductive treatment
    Ji Won Kim
    Department of Obstetrics and Gynecology, Fertility Center of CHA Gangnam Medical Center, CHA University, Seoul, Korea
    BMC Med Genet 11:153. 2010
    ..We also compared the rate of chromosomal abnormalities according to infertility causes in ICSI group...
  20. ncbi Intrauterine adhesions after conservative and surgical management of spontaneous abortion
    Wing Hung Tam
    Department of Obstetrics and Gynaecology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    J Am Assoc Gynecol Laparosc 9:182-5. 2002
    To determine the frequency of intrauterine adhesions (IUA) after conservative management, medical evacuation, and surgical evacuation for spontaneous abortion.
  21. ncbi Underreporting of induced and spontaneous abortion in the United States: an analysis of the 2002 National Survey of Family Growth
    Rachel K Jones
    Guttmacher Institute, 125 Maiden Lane, New York, NY 10038, USA
    Stud Fam Plann 38:187-97. 2007
    ..The levels of recent spontaneous abortion reported in the 2002 NSFG were consistent with the accumulated body of clinical research, although ..
  22. ncbi Caffeine metabolism and the risk of spontaneous abortion of normal karyotype fetuses
    L B Signorello
    International Epidemiology Institute, Rockville, Maryland 20850, USA
    Obstet Gynecol 98:1059-66. 2001
    To investigate whether the rate of caffeine metabolism influences spontaneous abortion risk.
  23. ncbi Autoimmune thyroid disease in pregnancy and the postpartum period: relationship to spontaneous abortion
    T Bagis
    Department of Gynecology and Obstetrics, Yuregir Adana, Turkey
    Thyroid 11:1049-53. 2001
    ..Fifty percent of the ATA-positive women and 14.1% of the ATA-negative group had a history of spontaneous abortion. Forty-eight of the ATA-positive women developed postpartum autoimmune thyroid dysfunction (PATD)...
  24. ncbi Statistical methods for estimating the probability of spontaneous abortion in observational studies--analyzing pregnancies exposed to coumarin derivatives
    Reinhard Meister
    Department of, Mathematics, University of Applied Sciences, Technische Fachhochschule Berlin, Luxemburger Strasse 10, 13353 Berlin, Germany
    Reprod Toxicol 26:31-5. 2008
    b>Spontaneous abortion rates are of general interest when investigating pregnancy outcome. In most studies observations are left truncated as pregnant women enter with a delay of several weeks after conception...
  25. ncbi Guilt and emptiness: women's experiences of miscarriage
    Annsofie Adolfsson
    Department of Obstetric and Gynecology, Karnsjukhuset, Skovde, Sweden
    Health Care Women Int 25:543-60. 2004
    ..They feel that they are the cause of the miscarriage through something they have done, eaten, or thought. They feel abandonment and they grieve for their profound loss; they are actually in bereavement...
  26. ncbi Comprehensive analysis of HLA-G: implications for recurrent spontaneous abortion
    Dara S Berger
    Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Reprod Sci 17:331-8. 2010
    Miscarriage is one of the most common pregnancy complications. Recurrent spontaneous abortion is defined as 2 or more pregnancy losses and may be associated with genetic variation...
  27. ncbi Insulin resistance increases the risk of spontaneous abortion after assisted reproduction technology treatment
    Li Tian
    Reproductive Medical Centre, Peking University, People s Hospital, No 11 South Street, Xizhimen, Beijing, China 100044
    J Clin Endocrinol Metab 92:1430-3. 2007
    This study aims to examine the impact of insulin resistance (IR) on the risk of spontaneous abortion in patients who received infertility treatment.
  28. ncbi Increased prevalence of T helper 17 (Th17) cells in peripheral blood and decidua in unexplained recurrent spontaneous abortion patients
    Wen Juan Wang
    Department of Obstetrics and Gynecology Renji Hospital, Shanghai Jiao Tong University School of Medicine, 145 Shandong Mid Road, Shanghai 200001, China
    J Reprod Immunol 84:164-70. 2010
    ..Th17 cells in human pregnancy and pathological pregnancy, especially in relation to unexplained recurrent spontaneous abortion (RSA), has not been investigated...
  29. ncbi Chromosome abnormalities identified in 347 spontaneous abortions collected in Japan
    Masaji Nagaishi
    Department of Obstetrics and Gynecology, Nihon University, School of Medicine, Tokyo, Japan
    J Obstet Gynaecol Res 30:237-41. 2004
    ..We determined the incidence of specific chromosome abnormalities in this Japanese population so that comparisons could be made to the incidence of chromosome abnormalities reported for other populations...
  30. ncbi Reproductive health indicators and outcomes among refugee and internally displaced persons in postemergency phase camps
    Michelle Hynes
    Division of Reproductive Health, National Center for Chronic Disease, Centers for Disease Control and Prevention, Mailstop K 22, 2900 Woodcock Blvd, Atlanta, GA 30341, USA
    JAMA 288:595-603. 2002
    ..Despite increasing awareness of the importance of reproductive health programs and services for refugee and internally displaced populations, there is a paucity of basic epidemiological data on reproductive health outcomes...
  31. ncbi Paternal age and maternal age are risk factors for miscarriage; results of a multicentre European study
    Elise de La Rochebrochard
    INED National Demographic Studies Institute, 75020 Paris, France
    Hum Reprod 17:1649-56. 2002
    ..However, studies usually investigate only maternal age effects. We investigated both maternal age and paternal age effects on miscarriage risk to provide insight into this frequent reproductive failure...
  32. ncbi The role of oxidative stress in spontaneous abortion and recurrent pregnancy loss: a systematic review
    Sajal Gupta
    Reproductive Research Center, Cleveland Clinic, Cleveland, Ohio, USA
    Obstet Gynecol Surv 62:335-47; quiz 353-4. 2007
    ..Before the end of the first trimester, 30%-50% of conceptions end in spontaneous abortion. Most losses occur at the time of implantation...
  33. ncbi Does caffeine and alcohol intake before pregnancy predict the occurrence of spontaneous abortion?
    J S Tolstrup
    Danish Epidemiology Science Centre at the Institute of Preventive Medicine, Kommunehospitalet, DK 1399, Copenhagen, Denmark
    Hum Reprod 18:2704-10. 2003
    ..Consumption of caffeine and alcohol is suspected to affect pregnancy outcome. Use of both stimulants is widespread and even minor effects on fetal viability are of public health interest...
  34. ncbi Th1-type immunity is incompatible with successful pregnancy
    R Raghupathy
    Dept of Microbiology, Faculty of Medicine, Kuwait University, Kuwait
    Immunol Today 18:478-82. 1997
    ..Here, evidence from murine and human pregnancy is presented to show that, since Th1-type cytokines mediate pregnancy loss, a shift towards Th1-type immunity may help resolve 'unexplained' pregnancy failure...
  35. pmc Prothrombin gene G20210A mutation and obstetric complications
    Robert M Silver
    Departments of Obstetrics and Gynecology at the University of Alabama at Birmingham, Birmingham, Alabama, USA
    Obstet Gynecol 115:14-20. 2010
    ..To estimate whether maternal carriage of the prothrombin gene G20210A mutation is associated with pregnancy loss, preeclampsia, placental abruption, or small for gestational age (SGA) neonates in a low-risk, prospective cohort...
  36. ncbi Moderate alcohol intake in pregnancy and the risk of spontaneous abortion
    Ulrik Kesmodel
    Perinatal Epidemiological Research Unit, Department of Obstetrics and Gynaecology, Aarhus University Hospital, Skejby Sygehus, 8200 Aarhus N, Denmark
    Alcohol Alcohol 37:87-92. 2002
    ..were eligible for this cohort study on the association between alcohol intake in pregnancy and the risk of spontaneous abortion. We included 24 679 singleton pregnancies in the study...
  37. ncbi Cumulative incidence of previous spontaneous abortion in Sweden in 1983-2003: a register study
    Annsofie Adolfsson
    Department of Obstetrics and Gynecology, Central Hospital, Skovde, Sweden
    Acta Obstet Gynecol Scand 85:741-7. 2006
    ..The aim of this study is to find out how common miscarriages are among women who have delivered a child...
  38. ncbi International comparison of studies using the perinatal grief scale: a decade of research on pregnancy loss
    L J Toedter
    Moravian College, Bethlehem, Pennsylvania, USA
    Death Stud 25:205-28. 2001
    ..Significantly higher scores were found in studies that recruited participants from support groups and self-selected populations rather than from medical sources, and from U.S. studies compared with those in Europe...
  39. ncbi Cytokine-dependent abortion in CBA x DBA/2 mice is mediated by the procoagulant fgl2 prothrombinase [correction of prothombinase]
    D A Clark
    McMaster University, Hamilton, Ontario, Canada
    J Immunol 160:545-9. 1998
    ..Cytokine-triggered thrombotic/inflammatory processes in maternal uteroplacental blood vessels causes abortion...
  40. ncbi Spontaneous abortion: a prospective cohort study of younger women from the general population in Denmark. Validation, occurrence and risk determinants
    L Buss
    Department of Virus, Hormones and Cancer, Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen
    Acta Obstet Gynecol Scand 85:467-75. 2006
    To assess the occurrence of spontaneous abortion, comparing two different data sources. To estimate the rate of spontaneous abortion over a 2-year period, and examine potential predictors of the risk for incident spontaneous abortion.
  41. ncbi How should data on murine spontaneous abortion rates be expressed and analyzed?
    David A Clark
    McMaster University Rm 3V39, Hamilton, ON, Canada
    Am J Reprod Immunol 60:192-6. 2008
    ..Recently, it has been argued that medians with box plots should replace the accepted standard, but this deprives readers of data needed to verify P-values, and leads to inferences incompatible with biological and statistical reality...
  42. ncbi Maternal occupational exposures and risk of spontaneous abortion in veterinary practice
    A Shirangi
    Department of Epidemiology and Public Health, Faculty of Medicine, Imperial College London, St Mary s Campus, Norfolk Place, London W21PG, UK
    Occup Environ Med 65:719-25. 2008
    To examine the relationship between occupational exposures and spontaneous abortion in female veterinarians.
  43. ncbi Rate of aneuploidy in miscarriages following in vitro fertilization and intracytoplasmic sperm injection
    Ruth B Lathi
    Stanford University Medical Center, Department of Obstetrics Gynecology, Division of Reproductive Endocrinology and Infertility, Stanford University Medical Center, Stanford, California 94305, USA
    Fertil Steril 81:1270-2. 2004
    ..To evaluate the incidence of aneuploidy in miscarriages after IVF and intracytoplasmic sperm injection (ICSI) procedures...
  44. ncbi Alleles and haplotypes of the estrogen receptor alpha gene are associated with an increased risk of spontaneous abortion
    Begoña Pineda
    Research Foundation, Hospital Clinico Universitario, Valencia, Spain
    Fertil Steril 93:1809-15. 2010
    ..To investigate whether polymorphisms in estrogen receptor alpha (ERalpha) or beta (ERbeta) genes are associated with a risk of miscarriage...
  45. ncbi Affective disorders in the aftermath of miscarriage: a comprehensive review
    C M Klier
    Department of Psychiatry, University of Vienna, Vienna Austria
    Arch Womens Ment Health 5:129-49. 2002
    ..In the final section, treatment options relevant to miscarriage are presented...
  46. ncbi Proportional change of CD4+CD25+ regulatory T cells after lymphocyte therapy in unexplained recurrent spontaneous abortion patients
    Hui Yang
    Department of Obstetrics and Gynecology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People s Republic of China
    Fertil Steril 92:301-5. 2009
    To investigate the proportional changes of CD4(+)CD25(+) regulatory T cells in peripheral blood after lymphocyte therapy in unexplained recurrent spontaneous abortion (URSA) patients.
  47. ncbi Mannan-binding lectin levels related to spontaneous abortion in Brazilian patients with celiac disease
    Lorete Maria da Silva Kotze
    Gastroenterology Service, Cajuru Hospital, Pontifical Catholic University of Parana, Curitiba, Parana, Brazil
    Dig Dis Sci 53:3152-7. 2008
    Low concentration of mannan-binding lectin (MBL) has been related to unexplained spontaneous abortion (SA), which has also been observed in an increased frequency in patients with celiac disease (CD)...
  48. ncbi Genetic changes in human fetuses from spontaneous abortion after in vitro fertilization detected by comparative genomic hybridization
    Yue Qiu Tan
    Institute of Reproduction and Stem Cell Engineering, Xiang Ya School of Medicine, Central South University, Changsha, Hunan 410078, China
    Biol Reprod 70:495-9. 2004
    ..It is believed that chromosomal abnormality is the major reason for early spontaneous abortion. Although some reports have mentioned cytogenetic changes in spontaneously aborted embryos after IVF, ..
  49. ncbi Risk of spontaneous abortion in singleton and twin pregnancies after IVF/ICSI
    Philippe Tummers
    Infertility Centre, University Hospital Ghent, De Pintelaan 185, B 9000 Gent, Belgium
    Hum Reprod 18:1720-3. 2003
    ..Although it is common knowledge that the incidence of abortion decreases as pregnancy progresses, exact data in relation to the duration of pregnancy are scarce...
  50. ncbi The influence of the environment and other exogenous agents on spontaneous abortion risk
    Mandy Weselak
    McLaughlin Centre for Population Health Risk Assessment, Institute of Population Health, University of Ottawa, Ottawa, Ontario, Canada
    J Toxicol Environ Health B Crit Rev 11:221-41. 2008
    It is estimated that close to 30% of all pregnancies end in spontaneous abortion. Although about 60% of spontaneous abortions are thought to be due to genetic, infectious, hormonal, and immunological factors, the role of the environment ..
  51. ncbi Plasma folate levels and risk of spontaneous abortion
    Lena George
    Department of Medical Epidemiology, Huddinge University Hospital, Karolinska Institutet, PO Box 281, SE 171 77 Stockholm, Sweden
    JAMA 288:1867-73. 2002
    Both folate deficiency and folic acid supplements have been reported to increase the risk of spontaneous abortion. The results are inconclusive, however, and measurements of folate have not been available in all studies.
  52. ncbi Preconception folate and vitamin B(6) status and clinical spontaneous abortion in Chinese women
    Alayne G Ronnenberg
    Department of Environmental Health, Program for Population Genetics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Obstet Gynecol 100:107-13. 2002
    To assess the association between preconception homocysteine and B vitamin status and risk of clinical spontaneous abortion in women from Anqing, China.
  53. ncbi Menstrual cycle characteristics: associations with fertility and spontaneous abortion
    Chanley M Small
    Department of Epidemiology, Emory University, 1518 Clifton Rd, Atlanta, Georgia 30322, USA
    Epidemiology 17:52-60. 2006
    ....
  54. pmc Aneuploidy in abortuses following IVF and ICSI
    Vitaly A Kushnir
    New Jersey Medical School, UMDNJ, Dept of Obstetrics, Gynecology and Women s Health, MSB E 506, 185 South Orange Avenue, Newark, NJ, 07101 1709, USA
    J Assist Reprod Genet 26:93-7. 2009
    ..To compare aneuploidy rates in first trimester pregnancy losses following IVF+/-ICSI...
  55. ncbi The associations of maternal caffeine consumption and nausea with spontaneous abortion
    W Wen
    Department of Medicine, School of Medicine, Vanderbilt University, Nashville, TN 37232-8300, USA
    Epidemiology 12:38-42. 2001
    To examine whether maternal caffeine consumption is associated with the risk of spontaneous abortion, we analyzed data from a population-based prospective study...
  56. ncbi Paternal age: are the risks of infecundity and miscarriage higher when the man is aged 40 years or over?
    E De La Rochebrochard
    Unité Inserm Ined 569, Hopital de Bicetre, 82, rue du General Leclerc, 94276 Le Kremlin Bicetre
    Rev Epidemiol Sante Publique 53:2S47-55. 2005
    ..However, the possibility of a paternal age effect has rarely been considered. We carried out review of the literature to investigate the effect of paternal age on the risks of infecundity and miscarriage...
  57. ncbi Inflammation and miscarriage
    Ole B Christiansen
    Fertility Clinic 4071, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Semin Fetal Neonatal Med 11:302-8. 2006
    ....
  58. ncbi Observational study of pregnant women with a previous spontaneous abortion before the 10th gestation week with and without antiphospholipid antibodies
    C Chauleur
    Research Team EA2992, Montpellier University 1, Nimes, France
    J Thromb Haemost 8:699-706. 2010
    ..Although this diagnostic classification of APS appeared to be the most sensitive, the APS-associated serological criteria are still debated...
  59. ncbi Does miscarriage in an initial pregnancy lead to adverse obstetric and perinatal outcomes in the next continuing pregnancy?
    S Bhattacharya
    Dugald Baird Centre for Research on Women s Health, Aberdeen Maternity Hospital, Aberdeen, UK
    BJOG 115:1623-9. 2008
    ..To explore pregnancy outcomes in women following an initial miscarriage...
  60. ncbi Increased activating killer immunoglobulin-like receptor genes and decreased specific HLA-C alleles in couples with recurrent spontaneous abortion
    Shan Wang
    Research Center for Reproductive Medicine, Shandong Provincial Hospital of Shandong University, Jinan 250021, China
    Biochem Biophys Res Commun 360:696-701. 2007
    ..corresponding specific HLA ligands in parent couples possessing a susceptibility to unexplained recurrent spontaneous abortion (RSA), we searched 73 pairs of childless couples with three or more abortions characterized as unexplained ..
  61. pmc Spontaneous abortion in a Danish population-based cohort of childhood cancer survivors
    Jeanette F Winther
    Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    J Clin Oncol 26:4340-6. 2008
    ..We assessed the risks for spontaneous abortion and stillbirths among cancer survivors who received radiotherapy and subsequently became pregnant.
  62. ncbi Mature cystic renal teratoma in a 25-year-old woman with ipsilateral hydronephrosis, urinary tract infection and spontaneous abortion
    M A Nzegwu
    Department of Morbid Anatomy, University of Benin Teaching Hospital, Benin City, Edo State, Nigeria
    Eur J Cancer Care (Engl) 16:300-2. 2007
    ..We report a case in which benign cystic renal teratoma was associated with ipsilateral hydronephrosis, urinary tract infection and spontaneous abortion, with histological confirmation in a 25-year-old woman.
  63. ncbi Abnormal folate metabolism as a risk factor for first-trimester spontaneous abortion
    Michael L Hoffman
    Department of Obstetrics and Gynecology, University of Illinois Medical Center at Chicago, USA
    J Reprod Med 53:207-12. 2008
    ..To assess the potential role of folic acid in early pregnancy loss by measuring homocysteine (hcy) levels in healthy, pregnant women who present with a current first-trimester miscarriage...
  64. ncbi Early risk factors for pregnancy loss in lupus
    Megan E B Clowse
    Department of Medicine, Division of Rheumatology, Duke University Medical Center, Durham, NC 27110, USA
    Obstet Gynecol 107:293-9. 2006
    ..To identify early risk factors for pregnancy loss in lupus pregnancies...
  65. ncbi Increased rate of endometriosis and spontaneous abortion in an in vitro fertilization program: no correlation with epidemiological factors
    Ioannis Matalliotakis
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut, USA
    Gynecol Endocrinol 24:194-8. 2008
    There are conflicting data concerning endometriosis and spontaneous abortion (SAB). The aim of the present study was to evaluate if there was any association between endometriosis and SAB...
  66. ncbi Alcohol consumption at the time of conception and spontaneous abortion
    Tine Brink Henriksen
    Perinatal Epidemiological Research Unit, Department of Obstetrics and Gynaecology, Aarhus University Hospital, Aarhus, Denmark
    Am J Epidemiol 160:661-7. 2004
    ..studied the association between female and male alcohol intakes at the time of conception and the risk of spontaneous abortion, including early pregnancy loss detected by urinary human chorionic gonadotropin...
  67. ncbi Japanese version of the Quality of Relationship Inventory: its reliability and validity among women with recurrent spontaneous abortion
    Yumi Nakano
    Department of Psychiatry, Nagoya City University Medical School, Aichi, Japan
    Psychiatry Clin Neurosci 56:527-32. 2002
    ..54, 95% CI 0.27-0.73 in the case of the father). Although we still need to examine the Japanese QRI with different populations, it appears to be a promising measure of individual-specific relationship for the Japanese population...
  68. ncbi Can endometrial infection/inflammation explain implantation failure, spontaneous abortion, and preterm birth after in vitro fertilization?
    Roberto Romero
    Perinatology Research Branch, National Institute of Child Health and Development, National Institutes of Health Department of Health and Human Services, Bethesda, Maryland, USA
    Fertil Steril 82:799-804. 2004
    ..and subclinical endometrial infection or inflammation may play a role in implantation failure after IVF, spontaneous abortion, and preterm birth...
  69. ncbi Is the exposure to antidepressant drugs in early pregnancy a risk factor for spontaneous abortion? A review of available evidences
    Giovanni Santone
    Psychiatric Unit, Department of Neuroscience, Polytechnic University of Marche, and United Hospitals of Ancona, Ancona, Italy
    Epidemiol Psichiatr Soc 18:240-7. 2009
    To review studies conducted to establish the risk of spontaneous abortion (SA) in women exposed to antidepressant drugs (ADs) during early pregnancy.
  70. ncbi Risks of repeated miscarriage
    Lena George
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Paediatr Perinat Epidemiol 20:119-26. 2006
    ..1, 4.1]). Among non-smoking women with high caffeine intake, there was an increased risk of repeated miscarriage, whereas there was no such association among smokers. Low plasma folate levels were not associated with increased risks...
  71. ncbi Lack of the appropriate natural killer cell inhibitory receptors in women with spontaneous abortion
    M Varla-Leftherioti
    Department of Immunobiology, Helena Venizelou Maternity Hospital, 11521 Athens, Greece
    Hum Immunol 66:65-71. 2005
    ....
  72. pmc Skewed X chromosome inactivation and trisomic spontaneous abortion: no association
    Dorothy Warburton
    Department of Genetics and Development, Columbia University, New York, NY 10032, USA
    Am J Hum Genet 85:179-93. 2009
    Several studies suggest that highly skewed X chromosome inactivation (HSXI) is associated with recurrent spontaneous abortion. We hypothesized that this association reflects an increased rate of trisomic conceptions due to anomalies on ..
  73. ncbi Incidence of spontaneous abortion in Bahrain before and after the Gulf War of 1991
    K E Rajab
    Department of Obstetrics and Gynecology, Salmaniya Medical Center, Bahrain
    Int J Gynaecol Obstet 68:139-44. 2000
    ..To analyze the clinical types, associated medical problems, morbidity, length of hospital stay and mortality rate of abortions...
  74. ncbi Misclassification of gestational age in the study of spontaneous abortion
    Penelope P Howards
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Bethesda, MD, USA
    Am J Epidemiol 164:1126-36. 2006
    Most studies of spontaneous abortion are subject to left truncation, because conception is not observed and thus pregnant women are enrolled postconception...
  75. ncbi Antiphospholipid/antiprotein antibodies, hemostasis-related autoantibodies, and plasma homocysteine as risk factors for a first early pregnancy loss: a matched case-control study
    Jean Christophe Gris
    Haematology Laboratory, University Hospital, F 30029 Nimes cedex 9, France
    Blood 102:3504-13. 2003
    ..1) and against tissue-type plasminogen activator (OR, 19.5; CI, 7.9-48.0), and high homocystinemia (OR, 4.1; CI, 1.3-12.5). A first early pregnancy loss is associated with increased levels of several autoantibodies and of homocysteine...
  76. pmc Chernobyl fallout and outcome of pregnancy in Finland
    A Auvinen
    STUK Radiation and Nuclear Safety Authority, Helsinki, Finland
    Environ Health Perspect 109:179-85. 2001
    ..Further, there is little support in the epidemiologic literature on effects of very low doses of radiation on pregnancy outcome...
  77. ncbi Dydrogesterone in the reduction of recurrent spontaneous abortion
    M Y el-Zibdeh
    Department of Obstetrics and Gynaecology, Islamic Hospital, Amman, P O Box 910201, Jordan
    J Steroid Biochem Mol Biol 97:431-4. 2005
    One hundred and eighty women with a history of recurrent, unexplained spontaneous abortion (mean 3.5 abortions) were randomised to receive oral dydrogesterone (10 mg b.i.d...
  78. ncbi Microchimerism after induced or spontaneous abortion
    Tomoko Sato
    Department of Obstetrics and Gynecology, School of Medicine, Fukushima Medical University, Fukushima, Japan
    Obstet Gynecol 112:593-7. 2008
    ..To investigate fetomaternal microchimerism in women with induced abortion or spontaneous pregnancy loss...
  79. ncbi Risk factors in miscarriage: a review
    A García-Enguídanos
    Department of Human Reproduction, Clínica Tambre, Madrid, Spain
    Eur J Obstet Gynecol Reprod Biol 102:111-9. 2002
    ..The only two etiologic factors recognized by all authors are uterine malformations and parental balanced chromosomal rearrangements. There have been many other suggested risk factors. In this revision we discuss these...
  80. ncbi Regulation of interleukin-6 fetoplacental levels could be involved in the protective effect of low-molecular weight heparin treatment on murine spontaneous abortion
    G Gutierrez
    Institute of Immunology, IDEHU, Univerity of Buenos Aires, Buenos Aires, Argentina
    Am J Reprod Immunol 51:160-5. 2004
    ..Heparin reduces significantly the abortion rate in mice and recurrent spontaneous abortion (RSA) patients...
  81. ncbi Male-mediated spontaneous abortion among spouses of stainless steel welders
    N H Hjollund
    Department of Occupational Medicine, Aarhus University Hospital, Aarhus C, Denmark
    Scand J Work Environ Health 26:187-92. 2000
    Male-mediated spontaneous abortion has never been documented for humans. The welding of stainless steel is associated with the pulmonary absorption of hexavalent chromium, which has genotoxic effects on germ cells in rodents...
  82. ncbi Interleukin-18 gene promoter polymorphisms and recurrent spontaneous abortion
    Sirous Naeimi
    Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran
    Eur J Obstet Gynecol Reprod Biol 128:5-9. 2006
    ..IL-18 is detected at the materno-fetal interface very soon in early pregnancy. Two polymorphisms in the promoter region of the IL-18 gene at positions of -607 and -137 appear to have functional impacts...
  83. ncbi HLA-E polymorphism in patients with recurrent spontaneous abortion
    R Steffensen
    Regional Centre for Blood Transfusion and Clinical Immunology, Aalborg Hospital, Denmark
    Tissue Antigens 52:569-72. 1998
    ..Since the HLA-E allele distribution was similar in women with recurrent spontaneous abortion and controls, it is suggested that maternal HLA-E polymorphism per se does not play any role in the ..
  84. ncbi Maternal smoking predicts the risk of spontaneous abortion
    Ann Nielsen
    Department of Virus, Hormones and Cancer, Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
    Acta Obstet Gynecol Scand 85:1057-65. 2006
    Few studies have examined smoking prior to pregnancy and the occurrence of spontaneous abortion, as most studies have addressed the risk of spontaneous abortion in relation to smoking during pregnancy...
  85. ncbi Negligible role of antibodies and C5 in pregnancy loss associated exclusively with C3-dependent mechanisms through complement alternative pathway
    Dailing Mao
    Rheumatology Division, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunity 19:813-22. 2003
    ..These findings provide significant insight into the role of the innate immune system in human pregnancy failure, a frequent clinical outcome...
  86. ncbi Uterine rupture of cesarean scar related to spontaneous abortion in the first trimester
    Koji Matsuo
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
    J Obstet Gynaecol Res 30:34-6. 2004
    ..Since uterine ruptures can occur during all gestational periods, it is important to pay attention to the uterine wall where any cesarean incision was previously made...
  87. ncbi Adrenomedullin and nitric oxide synthase at the maternal-decidual interface in early spontaneous abortion
    Emanuela Marinoni
    Laboratory of Perinatal Medicine and Molecular Biology, Institute of Gynecology, Perinatology and Child Health, University of Rome La Sapienza, Rome, Italy
    J Reprod Med 49:153-61. 2004
    To investigate local and systemic nitric oxide (NO) and adrenomedullin (AM) production in spontaneous abortion.
  88. pmc X-chromosome inactivation patterns in Korean women with idiopathic recurrent spontaneous abortion
    Jin Woo Kim
    Laboratory of Medical Genetics, Samsung Cheil Hospital and Women s Healthcare Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Korean Med Sci 19:258-62. 2004
    Recurrent spontaneous abortion (RSA) defines as two or more consecutive losses at < or = 20 weeks of gestation and affects an estimated 1 of every 100 couples wishing to have children. However, it remains a poorly understood phenomenon...
  89. ncbi Histologic, infectious, and molecular correlates of idiopathic spontaneous abortion and perinatal mortality
    Gerard J Nuovo
    Department of Pathology, Ohio State University Medical Center, Columbus, OH 43210, USA
    Diagn Mol Pathol 14:152-8. 2005
    ..Placentas and corresponding neonatal tissues in 21 consecutive cases of idiopathic spontaneous abortion or perinatal death, before or within 2 days of birth, were tested for an infectious agent...
  90. ncbi The number of dichorionic twin pregnancies is reduced by the common MTHFR 677C-->T mutation
    U Hasbargen
    Department of Obstetrics and Gynecology, Klinikum der Universitat Munchen, Grosshadern, Munich, Germany
    Hum Reprod 15:2659-62. 2000
    ..Our findings suggest that the MTHFR 677C-->T mutation interferes with human brood size, probably by influencing the proliferation of rapidly dividing embryonic and maternal cells...
  91. ncbi Maternal caffeine consumption and spontaneous abortion: a review of the epidemiologic evidence
    Lisa B Signorello
    International Epidemiology Institute, 1455 Research Blvd, Suite 550, Rockville, MD 20850, USA
    Epidemiology 15:229-39. 2004
    ..the 1980s, numerous studies have investigated whether caffeine intake during pregnancy affects the risk of spontaneous abortion. A clear consensus, however, has not been reached...
  92. ncbi Comparison of placental PTEN and beta1 integrin expression in early spontaneous abortion, early and late normal pregnancy
    Cigdem Tokyol
    Department of Pathology, Afyon Kocatepe University School of Medicine, Afyonkarahisar, Turkey
    Ups J Med Sci 113:235-42. 2008
    ..PTEN inhibits beta1 integrin signaling. The objective of this study is to investigate the expression of PTEN and beta1 integrin in placental tissues of early spontaneous abortion and first and third trimesters of normal pregnancy.
  93. ncbi Tumor necrosis factor receptor 1 expression and early spontaneous abortion
    X W Yu
    Center of Maternal and Child Health, First Hospital of Xi an Jiaotong University, Xi an, 710061 China
    Int J Gynaecol Obstet 88:44-8. 2005
    To compare tumor necrosis factor receptor 1 (TNFR1) protein expression in women with unexplained early spontaneous abortion (UESA) and normal pregnancy.
  94. ncbi Work schedule during pregnancy and spontaneous abortion
    Elizabeth A Whelan
    National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH 45226, USA
    Epidemiology 18:350-5. 2007
    ..There is inconsistent evidence as to whether work schedule (including rotating shifts and night work) can affect reproductive outcomes...
  95. ncbi A prospective study of maternal smoking and spontaneous abortion
    Kirsten Wisborg
    Perinatal Epidemiological Research Unit, Aarhus University Hospital, University of Aarhus, Denmark
    Acta Obstet Gynecol Scand 82:936-41. 2003
    Cigarette smoking has been considered a risk factor for spontaneous abortion, but conclusions from many studies may be impaired by methodological problems...
  96. ncbi Recurrent spontaneous abortion and skewed X-inactivation: is there an association?
    W Allen Hogge
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Obstet Gynecol 196:384.e1-6; discussion 384.e6-8. 2007
    The purpose of this study was to determine whether there is an association between skewed X-inactivation and recurrent spontaneous abortion in a large, well-defined sample of women with recurrent loss.
  97. ncbi Caffeine intake and the risk of spontaneous abortion
    Sven Cnattingius
    Food Chem Toxicol 41:1202; author reply 1203. 2003
  98. ncbi Elevation of adipsin, a complement activating factor, in the mouse placenta during spontaneous abortion
    Ai Takeshita
    Laboratory of Laboratory Animal Science, Department of Integrated Structural Biosciences, Division of Veterinary Science, Graduate School of Life and Environmental Biosciences, Osaka Prefecture University, Osaka 598 8531, Japan
    J Reprod Dev 56:508-14. 2010
    ..We have examined specific gene profiles in mouse placentas causing spontaneous abortion and found notable up-regulation of adipsin, a complement activating factor...
  99. ncbi Changes of maternal ACTH and oxytocinase plasma concentrations during the first trimester of spontaneous abortion
    M Klimek
    Department of Gynecology and Infertility, Jagiellonian University, Krakow, Poland
    Neuro Endocrinol Lett 26:342-6. 2005
    The labor at term finishes normal pregnancy. Both labor at term and first trimester spontaneous abortion are connected with increasing cytotoxic immune response within decidua...
  100. ncbi IDO expression on decidual and peripheral blood dendritic cells and monocytes/macrophages after treatment with CTLA-4 or interferon-gamma increase in normal pregnancy but decrease in spontaneous abortion
    Naoko Miwa
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Mol Hum Reprod 11:865-70. 2005
    ..both IDO expression on DC and monocytes after IFN-gamma treatment or CTLA-4 treatment were decreased in spontaneous abortion cases...
  101. pmc Maternal morbidity and mortality associated with interpregnancy interval: cross sectional study
    A Conde-Agudelo
    Latin American Centre for Perinatology and Human Development CLAP, Division of Health Promotion and Protection, Pan American Health Organisation, World Health Organisation, Montevideo, Uruguay
    BMJ 321:1255-9. 2000
    ..To study the impact of interpregnancy interval on maternal morbidity and mortality...

Research Grants62

  1. Cooperative Multicenter Reproductive Medicine Network (U10)
    MARCELLE IVONNE CEDARS; Fiscal Year: 2013
    ..apos;' RELEVANCE (See instructions): With increasing age, fertilitv declines and risk of spontaneous abortion increases...
  2. Validation of Novel Infertility Biomarker
    PETER SUTOVSKY SUTOVSKY; Fiscal Year: 2012
    ..We will examine how sperm SPTRX3 levels in male infertility patients correlate to a failure to conceive, to spontaneous abortion and to unwanted multiple births in their female partners treated by assisted reproductive therapies (ART)...
  3. Trophoblast MHC-I: Trigger for Immune-Mediated Rejection of Cloned Bovine Fetuses
    Kenneth L White; Fiscal Year: 2011
    ..Both spontaneous abortion and preeclampsia, which is associated with abnormal placentation, occur at increased frequency in human and ..
  4. Preconception Nutrition, Endocrine Disruptors, Reproductive Outcomes
    Xiaobin Wang; Fiscal Year: 2013
    ..Outcomes: menstrual disturbance, hormone dysfunction, time to conception, early pregnancy loss (EPL), spontaneous abortion (SAB), and birth outcomes (gestational age, birth weight, length, and head circumference);(3) Preconception ..
  5. Human Decidual Leukocytes and Their Placental Ligands
    JACK STROMINGER; Fiscal Year: 2009
    ..This project is directly related to reproductive failure in women, i.e. recurrent spontaneous abortion (RSA), some forms of infertility due to failure of implantation of the blastocyst, preeclampsia and fetal ..
  6. Development of a Univalent Vaccine Against Group B Streptococci Infection
    Stephen K Hunter; Fiscal Year: 2010
    ..Chorioamnionitis may lead to spontaneous abortion or stillbirth...
  7. Human Decidual Leukocytes and Their Placental Ligands
    Jack L Strominger; Fiscal Year: 2013
    ..This project is directly related to reproductive failure in women, i.e. recurrent spontaneous abortion (RSA), some forms of infertility due to failure of implantation of the blastocyst, preeclampsia and fetal ..
  8. Development of a Yoga Intervention for Antenatal Depression
    Cynthia L Battle; Fiscal Year: 2012
    ..Antenatal depression is linked to many adverse outcomes, including higher rates of spontaneous abortion, pre-eclampsia, operative delivery, postpartum depression, neonatal growth retardation, pre-term delivery, ..
  9. Luteal Progesterone Supplementation in Clomiphene Citrate-IUI Cycles
    KARL RICHARD HANSEN; Fiscal Year: 2013
    ..Secondary aims include evaluating differences in clinical pregnancy and spontaneous abortion rates in women treated with progesterone supplementation compared to women in the placebo control...
  10. Regulatory Costimulatory Pathways &Fetomaternal Tolerance
    Indira Guleria; Fiscal Year: 2012
    ..complex mechanisms of fetomaternal tolerance has important implications for developing novel strategies to prevent or reduce spontaneous abortion in at-risk populations in particular and in general to have better transplant tolerance.
  11. Age and molecular mechanisms contributing to aneuploidy in oocytes
    Richard M Schultz; Fiscal Year: 2013
    ..increases to 35% around 40 years-of-age, and is likely to be even higher because aneuploidy leading to a spontaneous abortion is frequently not recognized...
  12. The Immune Pathogenesis of Prenatal Listeria monocytogenes Infection
    Sing Sing Way; Fiscal Year: 2013
    ..and cytomegalovirus each have a defined predisposition for prenatal infection that often results in spontaneous abortion or stillbirth...
  13. Meiotic Interactions of the RecA Homologue Dmc1
    Douglas K Bishop; Fiscal Year: 2013
    ..in meiotic recombination cause chromosome non-disjunction and loss, both of which lead to birth defects and spontaneous abortion. Failure of recombinational repair in mitosis is implicated in the etiology of breast cancer and other ..
  14. Regulation of Chromosome Cohesion during Cell Cycle Progression
    Susannah Rankin; Fiscal Year: 2013
    ..thought to underlie the maternal age-related increase in aneuploid eggs, a major cause of birth defects and spontaneous abortion. Sister chromatid cohesion is mediated by a large protein complex called cohesin...
  15. Vitamin D and the prevalence, incidence, and persistence of bacterial vaginosis
    Abigail Norris Turner; Fiscal Year: 2012
    ..Pregnant women with BV have increased risks of spontaneous abortion, preterm labor, preterm birth, chorioamnionitis and other detrimental obstetric and gynecologic outcomes...
  16. TAS::75 0849::TAS CONTINUATION OF FOLLOW-UP OF DES-EXPOSED COHORT
    ARTHUR HERBST; Fiscal Year: 2010
    ..S. and Europe for the prevention of spontaneous abortion and premature delivery...
  17. TAS::75 0849::TAS CONTINUATION OF FOLLOW-UP OF DES-EXPOSED COHORTS
    Linda Titus Ernstoff; Fiscal Year: 2010
    ..S. and Europe for the prevention of spontaneous abortion and premature delivery...
  18. Role of ICOS-B7h Regulatory Costimulatory Pathway in Fetomaternal Tolerance
    Indira Guleria; Fiscal Year: 2010
    ..Understanding the complex mechanisms of fetomaternal tolerance has important implications for developing novel strategies to prevent or reduce spontaneous abortion in at-risk populations in particular.
  19. Centromere identity and function
    Ben E Black; Fiscal Year: 2013
    ..equal partitioning of chromosomes at cell division causes aneuploidy, a genetic catastrophe that results in spontaneous abortion or birth defects if it arises in the gametes and that is a major contributor to gene dosage imbalances in ..
  20. Molecular signaling in uterine receptivity to implantation
    Sudhansu K Dey; Fiscal Year: 2013
    ..More than 30% of conceptions result in spontaneous abortion with most losses occurring around the time of implantation due to an inadequate uterine milieu...
  21. Role of Host Cells in Invasive Listeriosis
    Anna Bakardjiev; Fiscal Year: 2013
    ..Listeria monocytogenes (NIAID Category B Priority Pathogen), which causes pregnancy complications including spontaneous abortion, preterm labor, and neonatal disease...
  22. ASPECTS OF BLASTOCYST IMPLANTATION
    Sudhansu K Dey; Fiscal Year: 2010
    ..Human reproduction is complex and not very efficient. More than 30% of conceptions result in spontaneous abortion with most losses occurring around the time of implantation due to an inappropriate uterine milieu...
  23. Array informatics to understand ploidy concordance
    Matthew Rabinowitz; Fiscal Year: 2010
    ..as aneuploidy, and implantation of such embryos can lead to undesired outcomes such as failed implantation, spontaneous abortion, or birth of a trisomic offspring...
  24. ORGANOPHOSPHATE PESTICIDES AND HUMAN REPRODUCTIVE HEALTH
    Xiping Xu; Fiscal Year: 2003
    ..FSH, TSH, SHBG, inhibin-B and testosterone in men; (4) fecundability; and (5) pregnancy outcomes including spontaneous abortion, preterm delivery, low birth weight and intrauterine growth retardation...
  25. Host-pathogen Interactions during Vertical Transmission of Listeria monocytogenes
    HOLLY ANN MORRISON; Fiscal Year: 2013
    ..Placental infections across gestational ages can result in spontaneous abortion, neonatal infection, and maternal and fetal morbidity and mortality...
  26. Childhood Abuse and PTSD: Associations with Select Reproductive Outcomes
    SABRINA CHARISE SELK; Fiscal Year: 2011
    ..exists between childhood maltreatment and adult pregnancy outcomes, such as, preterm delivery and spontaneous abortion. Furthermore, the relationship of psychopathology to reproductive outcomes will be explored, by assessing ..
  27. COOPERATIVE MULTICENTER REPRODUCTIVE MEDICINE NETWORK
    Sandra Carson; Fiscal Year: 1990
    ..investigate definitively with sufficient power the role of progesterone deficiency (LPD) in the etiology of spontaneous abortion. In subjects having at least one spontaneous abortion we will further determine not only sensitivity and ..
  28. Comprehensive aneuploidy diagnosis in single cells
    Nury Steuerwald; Fiscal Year: 2005
    ..normal and are often inadvertently transferred during IVF, leading to implantation failure or spontaneous abortion. Preimplantation screening of polar bodies (PBs) biopsied from oocytes allows normal oocytes to be ..
  29. Non-steroidal anti-inflammatory use and miscarriage
    Katherine E Hartmann; Fiscal Year: 2010
    ..Our objective is to examine prospectively the association of NSAID use with spontaneous abortion. We propose to enroll women who are planning a pregnancy and obtain daily diaries of medication use, ..
  30. HETEROGENEITY OF ESTROGEN RECEPTOR STRUCTURE AND ACTION
    Beth Schachter; Fiscal Year: 1993
    ..women with ER positive breast tumors, individuals carrying the variant gene had a much higher incidence of spontaneous abortion than did women who were homozygous for the more common allele...
  31. AMALGAM RESTORATIONS AND PREGNANCY OUTCOMES
    Richard Mitchell; Fiscal Year: 1993
    ..goal of this study is to determine whether restorations increase the risk that a pregnancy will end with a spontaneous abortion, stillbirth, low birth weight infant, or congenital abnormality...
  32. MERCURY AND REPRODUCTIVE HEALTH IN WOMEN DENTISTS
    David Savitz; Fiscal Year: 1992
    ..is to determine if occupational mercury exposure affects the fecundability (time to pregnancy) or risk of spontaneous abortion for women dentists...
  33. DDT, Endocrine Disruption and Reproductive Outcomes
    Xiaobin Wang; Fiscal Year: 2003
    ..AFP); (2) menstrual disorders; (3) reduced fecundability; and (4) adverse pregnancy outcomes including spontaneous abortion (SAB), preterm delivery, low birth weight, and intrauterine growth retardation (IUGR)...
  34. COMPARISON OF CHORION VILLUS SAMPLING AND AMNIOCENTESIS
    Eugene Pergament; Fiscal Year: 1990
    ..in the identification of chromosomally abnormal conceptions; and, whether CVS is associated with spontaneous abortion and other complications of pregnancy such as infection, low birth weight, congenital malformations or other ..
  35. UTERINE NK CELLS IN PRIMATE PREGNANCY
    Thaddeus G Golos; Fiscal Year: 2010
    ..pilot data demonstrating that NK cell immunodepletion has a negative impact on pregnancy outcome, causing spontaneous abortion within a week after anti-CD16 or anti-CD8 treatment...
  36. NONINVASIVE MEASURES OF STRESS & REPRODUCTIVE STERIODS
    Samuel Wasser; Fiscal Year: 1991
    Reproductive failure, including infertility and spontaneous abortion, is a growing concern to society. Psychosocial stress may be a significant, but treatable cause of reproductive failure...
  37. COMPARISON OF CHORION VILLUS SAMPLING AND AMNIOCENTESIS
    David Ledbetter; Fiscal Year: 1990
    ..two issues concerning CVS: 1) What is the risk? Specifically, is CVS associated with an increased rate of spontaneous abortion, pregnancy complications, or physical or developmental risk to the fetus? 2) Is the laboratory data from ..
  38. ROTATING SHIFTWORK AND REPRODUCTIVE OUTCOMES
    Xiping Xu; Fiscal Year: 2000
    ..Reproductive endpoints will include menstrual disturbance, time to conception, spontaneous abortion, preterm delivery, and low birthweight...
  39. TIME-DEPENDENT EFFECT OF ALCOHOL ON SPONTANEOUS ABORTION
    Gayle Windham; Fiscal Year: 1993
    ..is to assess the effect of moderate alcohol consumption at different stages of pregnancy on the risk of spontaneous abortion (SAB), using a unique data base...
  40. THE GENETIC ETIOLOGY OF HYPOPLASTIC LEFT HEART SYNDROME
    Peter Bowers; Fiscal Year: 2004
    ..neonatal presentation of the spectrum of left heart obstructive diseases, which includes first trimester spontaneous abortion, HLHS, aortic and mitral stenosis, coarctation and bicuspid aortic valve...
  41. Novel 3-D Model of Placental Cytomegalovirus Infection
    Cindy Morris; Fiscal Year: 2006
    ..can have catastrophic consequences not only on the neonate, but also on pregnancy outcome, including spontaneous abortion, intrauterine growth restriction and pre-eclampsia...
  42. EXTRACELLULAR MATRIX PRODUCTION BY UTERINE FIBROIDS
    ROMANA NOWAK; Fiscal Year: 1993
    ..with symptoms that include pelvic pain or pressure, excessive menstrual bleeding, infertility and spontaneous abortion. Leiomyomas appear to be estrogen/progesterone dependent but it is not clear how these ovarian steroids ..
  43. PERINATAL POLYDRUG ABUSE--COCAINE AND DRUG INTERACTIONS
    HISAYO MORISHIMA; Fiscal Year: 1999
    ..b>Spontaneous abortion, abruptio placentae, premature labor, or a ruptured membrane related to cocaine abuse are no longer ..
  44. Mechanism of Meiotic Pairing in Drosophila
    BRUCE MCKEE; Fiscal Year: 2007
    ..Errors in segregation lead to aneuploidy and are major causes of genetic disease and spontaneous abortion in humans. Meiosis consists of two divisions preceded by a single round of DNA replication...
  45. GENETIC AND BIOCHEMICAL STUDY OF HUMAN CHROMOSOME 21
    David Patterson; Fiscal Year: 1991
    ..of major mental retardation in the United States and a significant cause of congenital heart disease and spontaneous abortion. Down syndrome individuals are at increased risk for diseases which occur in the general population such as ..
  46. STATISTICAL METHODS FOR NONDISJUNCTION DATA
    Hongyu Zhao; Fiscal Year: 2001
    Chromosome imbalance is the leading known cause of mental retardation, spontaneous abortion, and congenital heart defects in human...
  47. LEAD, ENDOCRINE DISRUPTION AND REPRODUCTIVE OUTCOMES
    Xiping Xu; Fiscal Year: 2000
    ..Reproductive endpoints will include menstrual disturbance, time to conception, spontaneous abortion, preterm delivery, and low birth weight...
  48. Childhood Abuse and PTSD: The Impact on Preterm Delivery and Spontaneous Abortion
    SABRINA SELK; Fiscal Year: 2009
    ....
  49. MOLECULAR GENETIC STUDIES OF RECURRENT PREGNANCY LOSS
    Eric Hoffman; Fiscal Year: 2002
    ..The frequency of clinically recognized spontaneous abortion in the general population has been estimated to range between 15 and 20 percent of all recognized ..
  50. IMMUNOLOGICAL ASPECTS OF PREGNANCY IN HUMANS
    Thomas Gill; Fiscal Year: 1991
    ..immunogenetics of an apparently anomalous transplantation situation and into the pathogenesis of chronic spontaneous abortion and developmental anomalies...
  51. Treatment-Seeking for Depression Among Pregnant Women
    Cynthia Battle; Fiscal Year: 2009
    ..linked with numerous adverse consequences for mothers and developing infants, including higher rates of spontaneous abortion, preeclampsia, operative delivery, and postpartum depression...
  52. CELLULAR IMMUNITY--RECURRENT SPONTANEOUS ABORTION
    Joseph Hill; Fiscal Year: 1991
    ..The underlying hypothesis of this project is that recurrent spontaneous abortion is mediated by cellular immune mechanisms in a subgroup of women with otherwise unexplained etiology...
  53. OCCUPATIONAL DEMANDS IN WOMEN AND ADVERSE BIRTH OUTCOMES
    Laura Punnett; Fiscal Year: 1999
    ..position) upon the risk of antenatal, perinatal, and newborn specific outcomes such as early fetal loss, spontaneous abortion, and low birth weight infants...
  54. SIGNALING PATHWAYS MEDIATING TROPHOBLAST PROLIFERATION
    Daniel Rappolee; Fiscal Year: 2005
    ..proliferation or an imbalance between proliferation and differentiation may lead to pre-edampsia, IUGR or spontaneous abortion early after implantation of the embryo into the uterus, the time when most human conceptuses are lost...
  55. 2004 TERATOLOGY SOCIETY MEETINGS: TRAVEL FOR STUDENTS
    Thomas Knudsen; Fiscal Year: 2004
    ..cover: Neurobehavioral outcomes of common exposures; toxicokinetics and metabolism; perinatal epidemiology-spontaneous abortion; and computational systems biology and implications for developmental toxicology...
  56. HERPES & STIGMA
    Baruch Fischhoff; Fiscal Year: 2002
    ..Determining the role of BV in spontaneous abortion will allow establishment of interventions to decrease the fetal loss associated with second trimester ..
  57. Therapeutic Strategy for Recurrent Spontaneous Abortion
    Darryl Carter; Fiscal Year: 2005
    Recurrent spontaneous abortion (RSA) is a serious medical condition that affects approximately 1-3% of reproductive age women. At present, there is no FDA approved treatment for RSA...
  58. TROPHOBLAST CELLS
    Michael Soares; Fiscal Year: 1992
    ..with trophoblast cell growth, differentiation, or function result in impaired embryonic development of spontaneous abortion. Internationally recognized developmental and cell biologists as well as molecular endocrinologists ..
  59. MOUSE DEVELOPMENTAL MUTANTS DERIVED BY GENE TARGETING
    Mario Capecchi; Fiscal Year: 1993
    ..of human birth defects as well as human infertility problems resulting from early embryonic wastage and spontaneous abortion. Gene targeting, the homologous recombination of DNA sequences residing in the chromosome with newly ..