prenatal exposure delayed effects

Summary

Summary: The consequences of exposing the FETUS in utero to certain factors, such as NUTRITION; STRESS; DRUGS; RADIATION; and other physical or chemical factors. These consequences are observed later in the offspring after BIRTH.

Top Publications

  1. pmc Persistent epigenetic differences associated with prenatal exposure to famine in humans
    Bastiaan T Heijmans
    Departments of Molecular Epidemiology, Medical Statistics, and Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Proc Natl Acad Sci U S A 105:17046-9. 2008
  2. pmc Effect of in utero and early-life conditions on adult health and disease
    Peter D Gluckman
    Liggins Institute, University of Auckland, and National Research Centre for Growth and Development, Auckland, New Zealand
    N Engl J Med 359:61-73. 2008
  3. pmc Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced DNA methyltransferase-1 expression is involved in impaired DNA methylation and
    Karen A Lillycrop
    Development and Cell Biology, Biomedical Sciences Building, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Br J Nutr 97:1064-73. 2007
  4. ncbi Diet-induced obesity in female mice leads to offspring hyperphagia, adiposity, hypertension, and insulin resistance: a novel murine model of developmental programming
    Anne Maj Samuelsson
    Division of Reproduction and Endocrinology, King s College London, London, UK
    Hypertension 51:383-92. 2008
  5. pmc DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific
    Elmar W Tobi
    Molecular Epidemiology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands
    Hum Mol Genet 18:4046-53. 2009
  6. ncbi Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring
    Karen A Lillycrop
    Development and Cell Biology, University of Southampton, UK
    J Nutr 135:1382-6. 2005
  7. ncbi Antenatal maternal stress and long-term effects on child neurodevelopment: how and why?
    Nicole M Talge
    Institute of Child Development, University of Minnesota, USA
    J Child Psychol Psychiatry 48:245-61. 2007
  8. ncbi Childhood obesity and metabolic imprinting: the ongoing effects of maternal hyperglycemia
    Teresa A Hillier
    Center for Health Research, Kaiser Permanente Northwest, Portland, Oregon 97227, USA
    Diabetes Care 30:2287-92. 2007
  9. pmc Prenatal tobacco smoke exposure affects global and gene-specific DNA methylation
    Carrie V Breton
    Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    Am J Respir Crit Care Med 180:462-7. 2009
  10. pmc Prenatal infection and schizophrenia: a review of epidemiologic and translational studies
    Alan S Brown
    New York State Psychiatric Institute, New York, NY 10032, USA
    Am J Psychiatry 167:261-80. 2010

Research Grants

  1. MECHANISMS OF CHLORPYRIFOS DEVELOPMENTAL NEUROTOXICITY
    Theodore Slotkin; Fiscal Year: 2004
  2. Fetal & Adolescent Nicotine Effects on CNS 5HT Systems
    Theodore Slotkin; Fiscal Year: 2003
  3. DRUGS AND DEVELOPMENT OF THE ADRENERGIC NERVOUS SYSTEM
    Theodore Slotkin; Fiscal Year: 2003
  4. BIOMARKERS OF GENETIC DAMAGE AND ANTIOXIDANT
    Frederica Perera; Fiscal Year: 2001
  5. VULNERABILITY OF THE FETUS/INFANT TO PAH, PM2.5 AND ETS.
    Frederica Perera; Fiscal Year: 2004
  6. Neurodevelopmental Effects of Antiepileptic Drugs II
    Kimford Meador; Fiscal Year: 2009
  7. PRENATAL COCAINE USE--10 YEAR FOLLOW UP
    GALE RICHARDSON; Fiscal Year: 2003
  8. PARENTING AND INFANT DEVELOPMENT IN ALCOHOLIC FAMILIES
    RINA EIDEN; Fiscal Year: 2009
  9. TEEN TOBACCO USE IN A BIRTH COHORT & PRENATAL EFFECTS
    MARIE CORNELIUS; Fiscal Year: 2009
  10. Prenatal Programming of Infant Temperament
    Elysia Davis; Fiscal Year: 2008

Detail Information

Publications305 found, 100 shown here

  1. pmc Persistent epigenetic differences associated with prenatal exposure to famine in humans
    Bastiaan T Heijmans
    Departments of Molecular Epidemiology, Medical Statistics, and Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Proc Natl Acad Sci U S A 105:17046-9. 2008
    ..These data are the first to contribute empirical support for the hypothesis that early-life environmental conditions can cause epigenetic changes in humans that persist throughout life...
  2. pmc Effect of in utero and early-life conditions on adult health and disease
    Peter D Gluckman
    Liggins Institute, University of Auckland, and National Research Centre for Growth and Development, Auckland, New Zealand
    N Engl J Med 359:61-73. 2008
  3. pmc Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced DNA methyltransferase-1 expression is involved in impaired DNA methylation and
    Karen A Lillycrop
    Development and Cell Biology, Biomedical Sciences Building, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Br J Nutr 97:1064-73. 2007
    ..These findings suggest that induction in the offspring of altered epigenetic regulation of the hepatic GR1(10) promoter, and hence metabolic phenotype, may be due to reduced Dnmt1 expression...
  4. ncbi Diet-induced obesity in female mice leads to offspring hyperphagia, adiposity, hypertension, and insulin resistance: a novel murine model of developmental programming
    Anne Maj Samuelsson
    Division of Reproduction and Endocrinology, King s College London, London, UK
    Hypertension 51:383-92. 2008
    ..Developmentally programmed hyperphagia, physical inactivity, and altered adipocyte metabolism may play a mechanistic role...
  5. pmc DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific
    Elmar W Tobi
    Molecular Epidemiology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands
    Hum Mol Genet 18:4046-53. 2009
    ..017). Our data indicate that persistent changes in DNA methylation may be a common consequence of prenatal famine exposure and that these changes depend on the sex of the exposed individual and the gestational timing of the exposure...
  6. ncbi Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring
    Karen A Lillycrop
    Development and Cell Biology, University of Southampton, UK
    J Nutr 135:1382-6. 2005
    ..Epigenetic regulation of gene transcription provides a strong candidate mechanism for fetal programming...
  7. ncbi Antenatal maternal stress and long-term effects on child neurodevelopment: how and why?
    Nicole M Talge
    Institute of Child Development, University of Minnesota, USA
    J Child Psychol Psychiatry 48:245-61. 2007
    ....
  8. ncbi Childhood obesity and metabolic imprinting: the ongoing effects of maternal hyperglycemia
    Teresa A Hillier
    Center for Health Research, Kaiser Permanente Northwest, Portland, Oregon 97227, USA
    Diabetes Care 30:2287-92. 2007
    ..The purpose of this study was to determine how the range of measured maternal glycemia in pregnancy relates to risk of obesity in childhood...
  9. pmc Prenatal tobacco smoke exposure affects global and gene-specific DNA methylation
    Carrie V Breton
    Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    Am J Respir Crit Care Med 180:462-7. 2009
    ..Prenatal exposure to tobacco smoke increases the risk for diseases later in the child's life that may be mediated through alterations in DNA methylation...
  10. pmc Prenatal infection and schizophrenia: a review of epidemiologic and translational studies
    Alan S Brown
    New York State Psychiatric Institute, New York, NY 10032, USA
    Am J Psychiatry 167:261-80. 2010
    ..Finally, they discuss new approaches aimed at addressing current challenges in this area of research...
  11. ncbi The origins of the developmental origins theory
    D J P Barker
    DOHaD Division, University of Southampton, UK
    J Intern Med 261:412-7. 2007
    ..The association between low birthweight and coronary heart disease has been confirmed in longitudinal studies of men and women around the world. The developmental model of the origins of the disease offers a new way forward...
  12. ncbi Sexual dimorphism in environmental epigenetic programming
    Anne Gabory
    Inserm U Genetics and Epigenetics of Metabolic Diseases, Neurosensorial Diseases and Development, Clinique Maurice Lamy, Hopital Necker Enfants Malades, Paris, France
    Mol Cell Endocrinol 304:8-18. 2009
    ....
  13. ncbi Maternal infection requiring hospitalization during pregnancy and autism spectrum disorders
    Hjördis O Atladóttir
    Department of Epidemiology, Institute of Public Health, University of Aarhus, Bartholins Alle 2, Arhus C, Denmark
    J Autism Dev Disord 40:1423-30. 2010
    ..98 (CI: 1.29-7.15) and adjusted hazard ratio = 1.42 (CI: 1.08-1.87), respectively. Our results support prior hypotheses concerning early prenatal viral infection increasing the risk of ASDs...
  14. ncbi Neonatal leptin treatment reverses developmental programming
    M H Vickers
    Liggins Institute, Faculty of Medical and Health Science, University of Auckland and National Research Centre for Growth and Development, Auckland 1020, New Zealand
    Endocrinology 146:4211-6. 2005
    ..The complete normalization of the programmed phenotype by neonatal leptin treatment implies that leptin has effects that reverse the prenatal adaptations resulting from relative fetal undernutrition...
  15. pmc Sex-specific programming of offspring emotionality after stress early in pregnancy
    Bridget R Mueller
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 28:9055-65. 2008
    ..Overall, these results indicate that stress experience early in pregnancy may contribute to male neurodevelopmental disorders through impacts on placental function and fetal development...
  16. ncbi Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury
    P Grandjean
    Institute of Community Health, Odense University, Denmark
    Neurotoxicol Teratol 19:417-28. 1997
    ..The effects on brain function associated with prenatal methylmercury exposure therefore appear widespread, and early dysfunction is detectable at exposure levels currently considered safe...
  17. ncbi Early life events and their consequences for later disease: a life history and evolutionary perspective
    Peter D Gluckman
    Liggins Institute, University of Auckland, and National Research Centre for Growth and Development, Private Bag 92019, Auckland, New Zealand
    Am J Hum Biol 19:1-19. 2007
    ..This view of human disease from the perspectives of life history biology and evolutionary theory offers new approaches to prevention, diagnosis and intervention...
  18. pmc Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPAR alpha promoter of the offspring
    Karen A Lillycrop
    Development and Cell Biology, Biomedical Sciences Building, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Br J Nutr 100:278-82. 2008
    ..These data show for the first time that prenatal nutrition induces differential changes to the methylation of individual CpG dinucleotides in juvenile rats which persist in adults...
  19. ncbi Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases
    Robert A Waterland
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nutrition 20:63-8. 2004
  20. ncbi Endocrine disruptor vinclozolin induced epigenetic transgenerational adult-onset disease
    Matthew D Anway
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
    Endocrinology 147:5515-23. 2006
    ..The observations demonstrate that an environmental compound, endocrine disruptor, can induce transgenerational disease states or abnormalities, and this suggests a potential epigenetic etiology and molecular basis of adult onset disease...
  21. ncbi Perinatal and postnatal exposure to bisphenol a increases adipose tissue mass and serum cholesterol level in mice
    Joji Miyawaki
    Department of Bone and Joint Surgery, Ehime University Graduate School of Medicine, Ehime, Japan
    J Atheroscler Thromb 14:245-52. 2007
    ..To investigate whether the perinatal and postnatal exposure of mice to bisphenol A (BPA) caused the development of obesity and/or hyperlipidemia...
  22. ncbi Epidemiology-driven neurodevelopmental animal models of schizophrenia
    Urs Meyer
    Laboratory of Behavioural Neurobiology, Swiss Federal Institute of Technology ETH Zurich, Schorenstrasse 16, CH 8603 Schwerzenbach, Switzerland
    Prog Neurobiol 90:285-326. 2010
    ....
  23. ncbi Glucocorticoids, prenatal stress and the programming of disease
    Anjanette Harris
    University of Edinburgh, Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Horm Behav 59:279-89. 2011
    ..Intriguingly, the effects of a challenged pregnancy appear to be transmitted possibly to one or two subsequent generations, suggesting that these epigenetic effects persist...
  24. ncbi Effects of a high-fat diet exposure in utero on the metabolic syndrome-like phenomenon in mouse offspring through epigenetic changes in adipocytokine gene expression
    Hisashi Masuyama
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Kita ku, Okayama 700 8558, Japan
    Endocrinology 153:2823-30. 2012
    ..Thus, exposure to a high-fat diet in utero might cause a metabolic syndrome-like phenomenon through epigenetic modifications of adipocytokine, adiponectin, and leptin gene expression...
  25. pmc Maternal immune activation alters fetal brain development through interleukin-6
    Stephen E P Smith
    Biology Division, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 27:10695-702. 2007
    ....
  26. ncbi Endocrine disrupting chemicals and the developmental programming of adipogenesis and obesity
    Amanda Janesick
    Department of Developmental and Cell Biology, University of California, Irvine, 92697 2300, USA
    Birth Defects Res C Embryo Today 93:34-50. 2011
    ....
  27. ncbi Epigenetic epidemiology of the developmental origins hypothesis
    Robert A Waterland
    Department of Pediatrics, USDA Children s Nutrition Research Center, Baylor College of Medicine, Houston, TX, USA
    Annu Rev Nutr 27:363-88. 2007
    ....
  28. pmc Chronic consumption of a high-fat diet during pregnancy causes perturbations in the serotonergic system and increased anxiety-like behavior in nonhuman primate offspring
    Elinor L Sullivan
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Sciences University, Beaverton, Oregon 97006, USA
    J Neurosci 30:3826-30. 2010
    ..These findings have important clinical implications as they demonstrate that exposure to maternal HFD consumption during gestation, independent of obesity, increases the risk of developing behavioral disorders such as anxiety...
  29. ncbi Maternal antenatal anxiety and children's behavioural/emotional problems at 4 years. Report from the Avon Longitudinal Study of Parents and Children
    Thomas G O'Connor
    Institute of Psychiatry, Denmark Hill, London
    Br J Psychiatry 180:502-8. 2002
    ..Animal experiments suggest that maternal stress and anxiety during pregnancy have long-term effects on the behaviour of the offspring...
  30. pmc Prenatal exposure to PBDEs and neurodevelopment
    Julie B Herbstman
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, Columbia Center for Children s Environmental Health, New York, New York 10032, USA
    Environ Health Perspect 118:712-9. 2010
    ..Animal studies suggest that prenatal PBDE exposure may result in adverse neurodevelopmental effects...
  31. pmc Prenatal phthalate exposure is associated with childhood behavior and executive functioning
    Stephanie M Engel
    Department of Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Environ Health Perspect 118:565-71. 2010
    ..Experimental and observational studies have reported biological consequences of phthalate exposure relevant to neurodevelopment...
  32. pmc The environment and susceptibility to schizophrenia
    Alan S Brown
    Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, New York, NY 10032, USA
    Prog Neurobiol 93:23-58. 2011
    ....
  33. ncbi Maternal lifestyle factors in pregnancy risk of attention deficit hyperactivity disorder and associated behaviors: review of the current evidence
    Karen Markussen Linnet
    Perinatal Epidemiological Research Unit, Department of Obstetrics and Gynecology, the Psychiatric Hospital for Children and Adolescent, Skejby, Denmark
    Am J Psychiatry 160:1028-40. 2003
    ....
  34. ncbi Antenatal maternal anxiety and stress and the neurobehavioural development of the fetus and child: links and possible mechanisms. A review
    Bea R H Van den Bergh
    Department of Developmental Psychology, Catholic University of Leuven KULeuven, Tiensestraat 102, 3000 Leuven, Belgium
    Neurosci Biobehav Rev 29:237-58. 2005
    ..The magnitude of the long-term effects of antenatal maternal anxiety/stress on the child is substantial. Programs to reduce maternal stress in pregnancy are therefore warranted...
  35. pmc Chapel Hill bisphenol A expert panel consensus statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure
    Frederick S vom Saal
    Reprod Toxicol 24:131-8. 2007
  36. ncbi Maternal obesity during pregnancy and lactation programs the development of offspring non-alcoholic fatty liver disease in mice
    Jude A Oben
    University College London, Centre for Hepatology, Royal Free Hospital, London, UK
    J Hepatol 52:913-20. 2010
    ..Obesity and NAFLD rates in reproductive age women, and adolescents, are rising worldwide. Our hypothesis was that maternal obesity and lactation transmit to the offspring a pre-disposition to dysmetabolism, obesity and NAFLD...
  37. ncbi Fetal programming of coronary heart disease
    David J P Barker
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, SO16 6YD, Southampton, UK
    Trends Endocrinol Metab 13:364-8. 2002
    ..Coronary heart disease appears to be a developmental disorder that originates through two widespread biological phenomena, developmental plasticity and compensatory growth...
  38. pmc Prenatal airborne polycyclic aromatic hydrocarbon exposure and child IQ at age 5 years
    Frederica P Perera
    Department of Environmental Health Sciences, Columbia Center for Children s Environmental Healt, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Pediatrics 124:e195-202. 2009
    ..This study evaluated the relationship between prenatal exposure to airborne polycyclic aromatic hydrocarbons (PAHs) and child intelligence...
  39. ncbi The Danish National Birth Cohort--its background, structure and aim
    J Olsen
    Danish Epidemiology Science Centre, Statens Serum Institut, Copenhagen, Denmark
    Scand J Public Health 29:300-7. 2001
    ..By August 2000. a total of 60,000 pregnant women had been recruited to the study. It is expected that a large number of gene-environmental hypotheses need to be based on case-control analyses within a cohort like this...
  40. pmc Bisphenol A: Perinatal exposure and body weight
    Beverly S Rubin
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA 02111, United States
    Mol Cell Endocrinol 304:55-62. 2009
    ..The mechanisms through which perinatal BPA exposure acts to exert persistent effects on body weight and adiposity remain to be determined. Possible targets of BPA action are discussed...
  41. ncbi Immune involvement in schizophrenia and autism: etiology, pathology and animal models
    Paul H Patterson
    Biology Division, California Institute of Technology, Pasadena, CA 91125, USA
    Behav Brain Res 204:313-21. 2009
    ..The human and animal results related to immune involvement suggest novel therapeutic avenues based on immune interventions...
  42. ncbi Overweight and the metabolic syndrome in adult offspring of women with diet-treated gestational diabetes mellitus or type 1 diabetes
    Tine D Clausen
    Center for Pregnant Women with Diabetes, Department of Obstetrics, Rigshospitalet, The Capital Region of Denmark, Faculty of Health Sciences, University of Copenhagen, 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 94:2464-70. 2009
    ..In animal studies, exposure to intrauterine hyperglycemia increases the risk of cardiovascular disease through only partly understood epigenetic mechanisms. Human long-term follow-up studies on the same topic are few...
  43. pmc Fetal alcohol spectrum disorder: Canadian guidelines for diagnosis
    Albert E Chudley
    Children s Hospital, Health Sciences Centre, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Man
    CMAJ 172:S1-S21. 2005
    ..These are the first Canadian guidelines for the diagnosis of FAS and its related disabilities, developed by broad-based consultation among experts in diagnosis...
  44. pmc Antenatal thyroid screening and childhood cognitive function
    John H Lazarus
    Centre for Endocrine and Diabetes Sciences, Cardiff School of Medicine, Cardiff, Wales, United Kingdom
    N Engl J Med 366:493-501. 2012
    ..Children born to women with low thyroid hormone levels have been reported to have decreased cognitive function...
  45. pmc Maternal infection and immune involvement in autism
    Paul H Patterson
    Biology Division, California Institute of Technology, Pasadena, CA 91125, USA
    Trends Mol Med 17:389-94. 2011
    ..These rodent models are proving useful for the study of pathogenesis and gene-environment interactions as well as for the exploration of potential therapeutic strategies...
  46. ncbi Evidence of a complex association between dose, pattern and timing of prenatal alcohol exposure and child behaviour problems
    Colleen M O'Leary
    Division of Population Sciences, Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, WA, Australia
    Addiction 105:74-86. 2010
    ..There is a lack of evidence regarding the effect of dose, pattern and timing of prenatal alcohol exposure and behaviour problems in children aged 2 years and older...
  47. pmc Perinatal exposure to bisphenol a alters early adipogenesis in the rat
    Emmanuel Somm
    Faculty of Medicine, University of Geneva, Geneva, Switzerland
    Environ Health Perspect 117:1549-55. 2009
    ..The causes of the current obesity pandemic have not been fully elucidated. Implication of environmental endocrine disruptors such as bisphenol A (BPA) on adipose tissue development has been poorly investigated...
  48. pmc Bisphenol A exposure during pregnancy disrupts glucose homeostasis in mothers and adult male offspring
    Paloma Alonso-Magdalena
    Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Universidad Miguel Hernandez de Elche, Elche, Spain
    Environ Health Perspect 118:1243-50. 2010
    ..In humans, epidemiological evidence has associated BPA exposure in adults with higher risk of type 2 diabetes and heart disease...
  49. ncbi Role of nutrition and environmental endocrine disrupting chemicals during the perinatal period on the aetiology of obesity
    Jerrold J Heindel
    Division of Extramural Research and Training, National Institute of Environmental Health Sciences, NIH DHHS, Cellular, Organs and Systems Pathobiology Branch, Research Triangle Park, NC 27709, USA
    Mol Cell Endocrinol 304:90-6. 2009
    ..Eliminating exposures to these chemicals and improving nutrition during development offer the potential for reducing obesity and associated diseases...
  50. ncbi Dairy food, calcium and vitamin D intake in pregnancy, and wheeze and eczema in infants
    Y Miyake
    Dept of Public Health Faculty of Medicine, Fukuoka University, Fukuoka, Japan
    Eur Respir J 35:1228-34. 2010
    ..98), respectively). Higher consumption of calcium and dairy foods other than yoghurt during pregnancy may reduce the risk of infantile wheeze. Higher vitamin D intake during pregnancy may be protective against childhood wheeze and eczema...
  51. ncbi Prenatal exposure to antidepressant medications and neurodevelopmental outcomes: a systematic review
    Salvatore Gentile
    Department of Mental Health, ASL Salerno, Italy
    J Affect Disord 128:1-9. 2011
    ....
  52. ncbi Does prenatal cadmium exposure affect fetal and child growth?
    Chien Mu Lin
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, UK
    Occup Environ Med 68:641-6. 2011
    ..In this study we investigated the placental transport of cadmium and the effects of prenatal cadmium exposure on fetal and child growth in Taiwan...
  53. ncbi Hungry in the womb: what are the consequences? Lessons from the Dutch famine
    Tessa J Roseboom
    Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, Amsterdam, The Netherlands
    Maturitas 70:141-5. 2011
    ..Hunger is a major problem worldwide with one in seven inhabitants of this planet suffering from lack of food. Adequately feeding women before and during pregnancy may be a promising strategy in preventing chronic diseases worldwide...
  54. ncbi Annual Research Review: Prenatal stress and the origins of psychopathology: an evolutionary perspective
    Vivette Glover
    Institute of Reproductive and Developmental Biology, Imperial College London, UK
    J Child Psychol Psychiatry 52:356-67. 2011
    ..For example, there is some evidence that the type of cognitive deficits observed after prenatal stress have specific characteristics; these may be those which were adaptive in a past environment...
  55. ncbi Fetal origins of adult disease
    KARA CALKINS
    Department of Pediatrics, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA
    Curr Probl Pediatr Adolesc Health Care 41:158-76. 2011
    ..By understanding FOAD, health care professionals and policy makers will make this issue a high health care priority and implement preventive measures and treatment for those at higher risk for chronic diseases...
  56. ncbi Familial factors confound the association between maternal smoking during pregnancy and young adult offspring overweight
    Anastasia Nyman Iliadou
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Int J Epidemiol 39:1193-202. 2010
    ..We aim to investigate whether familial factors confound the association between maternal smoking during pregnancy and overweight in early adulthood in young Swedish males born 1983-88...
  57. pmc Maternal tobacco use modestly alters correlated epigenome-wide placental DNA methylation and gene expression
    Melissa Suter
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Baylor College of Medicine, Houston, TX, USA
    Epigenetics 6:1284-94. 2011
    ..These studies suggest that a common perinatal exposure (such as maternal smoking) deregulates placental methylation in a CpG site-specific manner that correlates with meaningful alterations in gene expression along signature pathways...
  58. ncbi Serum vaccine antibody concentrations in children exposed to perfluorinated compounds
    Philippe Grandjean
    Department of Environmental Health, Harvard School of Public Health, 401 Park Dr, EOME 3E 110, Boston, MA 02215, USA
    JAMA 307:391-7. 2012
    ..They cause immune suppression in a rodent model at serum concentrations similar to those occurring in the US population, but adverse health effects of PFC exposure are poorly understood...
  59. ncbi Living with the past: evolution, development, and patterns of disease
    Peter D Gluckman
    Liggins Institute, University of Auckland and National Research Centre for Growth and Development, 2 6 Park Avenue, Grafton, Private Bag 92019, Auckland, New Zealand
    Science 305:1733-6. 2004
    ..This "developmental origins of health and disease" concept may have important biological, medical, and socioeconomic implications...
  60. pmc Maternal nutritional history predicts obesity in adult offspring independent of postnatal diet
    G J Howie
    Liggins Institute and National Research Centre for Growth and Development, University of Auckland, Grafton, Auckland, New Zealand
    J Physiol 587:905-15. 2009
    ....
  61. ncbi Impact of maternal obesity on offspring obesity and cardiometabolic disease risk
    Amanda J Drake
    Endocrinology Unit, Queen s Medical Research Institute, Centre for Cardiovascular Sciences, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 6TJ, UK
    Reproduction 140:387-98. 2010
    ..The ultimate aim is to identify potential targets, which may be amenable to prevention or early intervention in order to improve the health of this and future generations...
  62. ncbi Arsenic exposure during pregnancy and size at birth: a prospective cohort study in Bangladesh
    Anisur Rahman
    International Centre for Diarrhoeal Disease Research, Bangladesh, Mohakhali, Dhaka, Bangladesh
    Am J Epidemiol 169:304-12. 2009
    ..14 (SE, 0.03) mm per 1 microg/L, respectively. No further negative effects were shown at higher levels of arsenic exposure. The indicated negative effect on birth size at a low level of arsenic exposure warrants further investigation...
  63. ncbi Fetal programming and adult health
    K M Godfrey
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, UK
    Public Health Nutr 4:611-24. 2001
    ..Although the influences that impair fetal development and programme adult cardiovascular disease remain to be defined, there are strong pointers to the importance of maternal body composition and dietary balance during pregnancy...
  64. ncbi Intrauterine exposure to alcohol and tobacco use and childhood IQ: findings from a parental-offspring comparison within the Avon Longitudinal Study of Parents and Children
    Rosa Alati
    School of Population Health, University of Queensland, Herston, Queensland, 4006 Australia
    Pediatr Res 64:659-66. 2008
    ..Our findings suggest that the relationship between maternal moderate alcohol and tobacco use in early pregnancy and childhood IQ may not be explained by intrauterine mechanisms...
  65. ncbi Mechanisms involved in the developmental programming of adulthood disease
    Matthew J Warner
    Institute of Metabolic Science, Addenbrooke s Hospital, University of Cambridge, UK
    Biochem J 427:333-47. 2010
    ....
  66. ncbi Early onset of coronary artery disease after prenatal exposure to the Dutch famine
    Rebecca C Painter
    Department of Clinical Epidemiology and Biostatistics and the Developmental Origins of Adult Disease Centre, University of Southampton, Southampton, United Kingdom
    Am J Clin Nutr 84:322-7; quiz 466-7. 2006
    ..Limited evidence suggests that maternal undernutrition at the time of conception is associated with increased cardiovascular disease risk in adult offspring...
  67. ncbi Transient prenatal Vitamin D deficiency is associated with hyperlocomotion in adult rats
    Thomas H J Burne
    Centre for Molecular Neurobiology, School of Biomolecular and Biomedical Science, Griffith University, Brisbane, QLD 4111, Australia
    Behav Brain Res 154:549-55. 2004
    ..Thus, transient prenatal Vitamin D deficiency induces hyperlocomotion in adulthood, without severe motor abnormalities...
  68. pmc Prenatal environmental exposures, epigenetics, and disease
    Frederica Perera
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, NY, United States
    Reprod Toxicol 31:363-73. 2011
    ..The findings discussed indicate that identification of environmental chemicals that dysregulate the prenatal epigenome should be a priority in health research and disease prevention...
  69. ncbi The short- and long-term implications of maternal obesity on the mother and her offspring
    P M Catalano
    Department of Reproductive Biology, Case Western Reserve University, MetroHealth Medical Center, Cleveland, OH 44109, USA
    BJOG 113:1126-33. 2006
    ..Additionally, we will review evidence of both short- and long-term effect of maternal obesity on the in utero environment as it relates to fetal growth, neonatal body composition and adolescent obesity...
  70. pmc Prenatal exposure to perfluorooctanoate and risk of overweight at 20 years of age: a prospective cohort study
    Thorhallur I Halldorsson
    Center for Fetal Programming, Department of Epidemiology Research, Statens Serum Institute, Copenhagen, Denmark
    Environ Health Perspect 120:668-73. 2012
    ..A recent study on low-dose developmental exposure to PFOA in mice reported increased weight and elevated biomarkers of adiposity in postpubertal female offspring...
  71. ncbi Prenatal stress and brain development
    Arnaud Charil
    McGill University, Department of Psychiatry, Montreal, Quebec, Canada
    Brain Res Rev 65:56-79. 2010
    ....
  72. pmc Association of endocrine disruptors and obesity: perspectives from epidemiological studies
    E E Hatch
    Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA
    Int J Androl 33:324-32. 2010
    ..As this field of research advances, there are challenging methodological questions that must be considered by both epidemiologists and toxicologists...
  73. ncbi Effects of in utero arsenic exposure on child immunity and morbidity in rural Bangladesh
    Rubhana Raqib
    International Centre for Diarrhoeal Disease Research, Bangladesh ICDDR, B, Dhaka, Bangladesh
    Toxicol Lett 185:197-202. 2009
    ..The effect seemed to be partially gender dependent. Arsenic exposure also affected breast milk content of trophic factors and maternal morbidity...
  74. pmc Prenatal interaction of mutant DISC1 and immune activation produces adult psychopathology
    Bagrat Abazyan
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, USA
    Biol Psychiatry 68:1172-81. 2010
    ..We evaluated interaction between mutant human disrupted-in-schizophrenia 1 (mhDISC1) and maternal immune activation implicated in schizophrenia and mood disorders...
  75. ncbi Effects of prenatal infection on brain development and behavior: a review of findings from animal models
    Patricia Boksa
    Department of Psychiatry, McGill University, Douglas Mental Health University Institute, Montreal, Verdun, Quebec, Canada
    Brain Behav Immun 24:881-97. 2010
    ..Directions for further research are discussed...
  76. ncbi The Dutch famine and its long-term consequences for adult health
    Tessa Roseboom
    Department of Clinical Epidemiology Biostatistics and Bioinformatics, Academic Medical Center, Amsterdam, The Netherlands
    Early Hum Dev 82:485-91. 2006
    ..Especially early gestation seems to be a vulnerable period. Adequate dietary advice to women before and during pregnancy seems a promising strategy in preventing chronic diseases in future generations...
  77. ncbi Maternal smoking during pregnancy and offspring obesity: meta-analysis
    Toshihiro Ino
    Gumma Paz College, School of Health Science, Agatsuma, Gumma, Japan
    Pediatr Int 52:94-9. 2010
    ....
  78. pmc Environmental phthalate exposure in relation to reproductive outcomes and other health endpoints in humans
    Shanna H Swan
    Department of Obstetrics and Gynecology, School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Box 668, Rochester, NY 14642, USA
    Environ Res 108:177-84. 2008
    ..Replication of the results described here and further mechanistic studies are needed to strengthen links between phthalates and adverse health outcomes...
  79. pmc Prenatal organochlorine exposure and behaviors associated with attention deficit hyperactivity disorder in school-aged children
    Sharon K Sagiv
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Epidemiol 171:593-601. 2010
    ..76, 95% confidence interval: 1.06, 2.92) and a similar relation for p,p'-DDE. These results support an association between low-level prenatal organochlorine exposure and ADHD-like behaviors in childhood...
  80. pmc Sex differences in the developmental origins of hypertension and cardiorenal disease
    Jeffrey S Gilbert
    Department of Physiology and Pharmacology, University of Minnesota Medical School Duluth, Duluth, MN 55812, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1941-52. 2008
    ....
  81. pmc Effects of arsenic exposure on DNA methylation and epigenetic gene regulation
    John F Reichard
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati College of Medicine, 3223 Eden Avenue, Cincinnati, OH 45267 0056, USA
    Epigenomics 2:87-104. 2010
    ..Here, we discuss the evidence supporting changes in DNA methylation as a cause of arsenic carcinogenesis and highlight the strengths and limitations of these studies, as well as areas where consistencies and inconsistencies exist...
  82. pmc Impact of prenatal chlorpyrifos exposure on neurodevelopment in the first 3 years of life among inner-city children
    Virginia A Rauh
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, 60 Haven Ave, B 109, New York, NY 10032, USA
    Pediatrics 118:e1845-59. 2006
    ..The purpose of this study was to investigate the impact of prenatal exposure to chlorpyrifos on 3-year neurodevelopment and behavior in a sample of inner-city minority children...
  83. ncbi Exposure to hexachlorobenzene during pregnancy increases the risk of overweight in children aged 6 years
    Agnes Smink
    Center for Research in Environmental Epidemiology, Institut Municipal Investigacio Medica, Barcelona, Spain
    Acta Paediatr 97:1465-9. 2008
    ..To determine whether prenatal exposure to hexachlorobenzene (HCB) has potential adverse effects on child's weight and body mass index (BMI) in a general population with no local pollution sources...
  84. ncbi Maternal vitamin D deficiency alters the expression of genes involved in dopamine specification in the developing rat mesencephalon
    Xiaoying Cui
    Queensland Brain Institute, University of Queensland, QLD 4072, Australia
    Neurosci Lett 486:220-3. 2010
    ..Reductions in these specification factors may alter the ontogeny of DA neurons and may ultimately help to explain the behavioural abnormalities reported in adult offspring from this model...
  85. ncbi Metabolic programming, epigenetics, and gestational diabetes mellitus
    Sara E Pinney
    Division of Endocrinology and Diabetes, Department of Pediatrics, The Children s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA
    Curr Diab Rep 12:67-74. 2012
    ....
  86. pmc Prenatal smoking might not cause attention-deficit/hyperactivity disorder: evidence from a novel design
    Anita Thapar
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, United Kingdom
    Biol Psychiatry 66:722-7. 2009
    ..It is, however, impossible to be certain of adequate control for confounding factors with observational designs. We use a novel "natural experiment" design that separates prenatal environmental from alternative inherited effects...
  87. ncbi Associations between fetal size, maternal {alpha}-tocopherol and childhood asthma
    Stephen W Turner
    Department of Child Health, University of Aberdeen, Royal Aberdeen Children s Hospital, Foresterhill, Aberdeen AB25 2ZG, UK
    Thorax 65:391-7. 2010
    ..002). CONCLUSIONS These findings support the concept of very early fetal programming of respiratory disease. Maternal vitamin E status may be one determinant for growth of the fetus and fetal lungs during early pregnancy...
  88. pmc Experimental models of developmental programming: consequences of exposure to an energy rich diet during development
    James A Armitage
    Maternal and Fetal Research Unit, Division of Reproductive Health, Endocrinology and Development, GKT School of Medicine, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
    J Physiol 565:3-8. 2005
    ..These suggest that maternal over-nutrition is deleterious to the health of offspring and can result in a phenotype of the offspring that is characteristic of metabolic syndrome...
  89. ncbi Effects of pre and postnatal exposure to low levels of polybromodiphenyl ethers on neurodevelopment and thyroid hormone levels at 4 years of age
    Mireia Gascon
    Center for research in environmental epidemiology CREAL, Dr Aiguader 88, 08003 Barcelona, Spain
    Environ Int 37:605-11. 2011
    ..In the light of current evidence a precautionary approach towards PBDE exposure of both mothers and children seems warranted...
  90. pmc Perinatal exposure to low doses of dioxin can permanently impair human semen quality
    Paolo Mocarelli
    University Department of Laboratory Medicine, Hospital of Desio, Monza Brianza, Italy
    Environ Health Perspect 119:713-8. 2011
    ..In recent decades, young men in some industrialized areas have reportedly experienced a decrease in semen quality...
  91. pmc Maternal smoking during pregnancy and offspring growth in childhood: 1993 and 2004 Pelotas cohort studies
    Alicia Matijasevich
    Postgraduate Programme in Epidemiology, Federal University of Pelotas, Rua Marechal Deodoro 1160, Pelotas, RS, Brazil
    Arch Dis Child 96:519-25. 2011
    ....
  92. ncbi Plasma lipid profiles in adults after prenatal exposure to the Dutch famine
    T J Roseboom
    Departments of Clinical Epidemiology and Biostatistics and Obstetrics and Gynecology, The Academic Medical Center, The University of Amsterdam, Netherlands
    Am J Clin Nutr 72:1101-6. 2000
    ..There is no direct evidence in humans that maternal malnutrition during pregnancy affects the lipid profiles of the offspring...
  93. ncbi Maternal smoking in pregnancy, adult adiposity and other risk factors for cardiovascular disease
    C Power
    UCL Institute of Child Health, UK
    Atherosclerosis 211:643-8. 2010
    ..To establish whether maternal smoking in pregnancy is associated with risk factors for cardiovascular disease (CVD) in mid-adulthood and whether associations are explained by postnatal influences...
  94. ncbi Prenatal exposure to maternal depression and cortisol influences infant temperament
    Elysia Poggi Davis
    Department of Psychiatry and Human Behavior, University of California, Irvine, USA
    J Am Acad Child Adolesc Psychiatry 46:737-46. 2007
    ..Few prospective studies of human pregnancy have examined the consequences of prenatal exposure to stress and stress hormones...
  95. pmc Dietary protein restriction of pregnant rats in the F0 generation induces altered methylation of hepatic gene promoters in the adult male offspring in the F1 and F2 generations
    Graham C Burdge
    Developmental Origins of Health and Disease Division, University of Southampton, Southampton, UK
    Br J Nutr 97:435-9. 2007
    ..This may represent a mechanism for the transmission of induced phenotypes between generations..
  96. ncbi Associations of gestational weight gain with offspring body mass index and blood pressure at 21 years of age: evidence from a birth cohort study
    Abdullah A Mamun
    School of Population Health, University of Queensland, Herston Rd, Herston, QLD 4006, Australia
    Circulation 119:1720-7. 2009
    ....
  97. pmc Maternal obesity is necessary for programming effect of high-fat diet on offspring
    Christy L White
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Am J Physiol Regul Integr Comp Physiol 296:R1464-72. 2009
    ..Together, these data suggest that maternal adiposity, and not dietary fat per se, induces hyperleptinemia and insulin resistance in offspring, as well as an increased body weight that persists into adulthood...
  98. ncbi Early life origins of insulin resistance and type 2 diabetes in India and other Asian countries
    C S Yajnik
    Diabetes Unit, King Edward Memorial Hospital and Research Center, Rasta Peth, Pune 411011, India
    J Nutr 134:205-10. 2004
    ..These factors may be amenable to correction. Prevention of type 2 diabetes must begin in utero and continue throughout the life course...
  99. pmc In utero exposure to bisphenol A shifts the window of susceptibility for mammary carcinogenesis in the rat
    Angela M Betancourt
    Department of Pharmacology and Toxicology, Preventive Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Environ Health Perspect 118:1614-9. 2010
    ..Bisphenol A (BPA) is a ubiquitous environmental chemical with reported endocrine-disrupting properties...
  100. pmc Low protein diet fed exclusively during mouse oocyte maturation leads to behavioural and cardiovascular abnormalities in offspring
    Adam J Watkins
    School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    J Physiol 586:2231-44. 2008
    ..Similar and distinct postnatal outcomes were observed here compared with maternal LPD treatment during post-fertilization preimplantation development which may reflect the relative contribution of the paternal genome...
  101. ncbi Fetal origins of adult disease: strength of effects and biological basis
    D J P Barker
    Medical Research Council Environmental Epidemiology Unit, Southampton SO16 6YD, UK
    Int J Epidemiol 31:1235-9. 2002
    ....

Research Grants74

  1. MECHANISMS OF CHLORPYRIFOS DEVELOPMENTAL NEUROTOXICITY
    Theodore Slotkin; Fiscal Year: 2004
    ..Molecular mechanisms of developmental neurotoxicity can be determined and linked to eventual alterations in behavioral performance. ..
  2. Fetal & Adolescent Nicotine Effects on CNS 5HT Systems
    Theodore Slotkin; Fiscal Year: 2003
    ..abstract_text> ..
  3. DRUGS AND DEVELOPMENT OF THE ADRENERGIC NERVOUS SYSTEM
    Theodore Slotkin; Fiscal Year: 2003
    ....
  4. BIOMARKERS OF GENETIC DAMAGE AND ANTIOXIDANT
    Frederica Perera; Fiscal Year: 2001
    ..Once validated in this model population, these biomarkers would also have applicability in evaluating interventions in occupational cohorts and other populations highly exposed to carcinogens. ..
  5. VULNERABILITY OF THE FETUS/INFANT TO PAH, PM2.5 AND ETS.
    Frederica Perera; Fiscal Year: 2004
    ....
  6. Neurodevelopmental Effects of Antiepileptic Drugs II
    Kimford Meador; Fiscal Year: 2009
    ..The NEAD study has an invaluable cohort, and the results of this continuation proposal will impact the clinical management of women receiving these medications, and improve the health of their children. ..
  7. PRENATAL COCAINE USE--10 YEAR FOLLOW UP
    GALE RICHARDSON; Fiscal Year: 2003
    ..abstract_text> ..
  8. PARENTING AND INFANT DEVELOPMENT IN ALCOHOLIC FAMILIES
    RINA EIDEN; Fiscal Year: 2009
    ..abstract_text> ..
  9. TEEN TOBACCO USE IN A BIRTH COHORT & PRENATAL EFFECTS
    MARIE CORNELIUS; Fiscal Year: 2009
    ..Also, with further physical and CNS maturation in adolescence, we can assess whether effects of PTE on growth, cognitive, neuropsychological, and behavioral outcomes are maintained and whether new deficits occur with maturation. ..
  10. Prenatal Programming of Infant Temperament
    Elysia Davis; Fiscal Year: 2008
    ..Prospective studies, such as this one, are needed to better understand processes that might underlie this association. [unreadable] [unreadable] [unreadable]..
  11. Prenatal Glucocorticoids Influence Brain and Behavior
    Elysia Poggi Davis; Fiscal Year: 2010
    ..This project will provide the first opportunity to examine the independent influence of fetal exposure to GC's in a group of children born at term. ..
  12. DEVELOPMENTAL INSULT AND BRAIN ANOMALY IN SCHIZOPHRENIA
    Alan Brown; Fiscal Year: 2004
    ....
  13. Prenatal Factors and Risk of Bipolar Disorder
    ALAN STEWART BROWN; Fiscal Year: 2010
    ....
  14. Serologic Studies of Prenatal Factors in Schizophrenia
    Alan Brown; Fiscal Year: 2002
    ..For this purpose, we shall quantify levels of these cytokines in 100 SSD cases and their respective matched controls, and compare these levels between the groups. ..
  15. Prenatal factors and risk of autism in a Finnish national birth cohort
    ALAN STEWART BROWN; Fiscal Year: 2010
    ....
  16. Maternal Opioid Treatment: Human Experimental Research
    Barry Lester; Fiscal Year: 2009
    ..abstract_text> ..
  17. Prenatal Alcohol Exposure: Adult Neurocognition
    Claire Coles; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  18. Prenatal Tobacco Use: Auditory Processing and Language
    Claire Coles; Fiscal Year: 2007
    ..All analyses will control for other contributions to outcomes (i.e., Alcohol exposure, Caregiving potential, Quality of Caregiving, including language environment, Child Health and Hearing). ..
  19. Neurohormonal Effects of Massage Therapy
    Tiffany Field; Fiscal Year: 2007
    ..The K05 would allow me to increase my research time including being mentored and mentoring students from 25 to 75% time. [unreadable] [unreadable] [unreadable]..
  20. Role of D3 dopamine receptor in behavioral sensitization
    NEIL RICHTAND; Fiscal Year: 2007
    ..Significantly, these studies may also elucidate a previously unrecognized mechanism regulating receptor desensitization and trafficking relevant to other receptor systems and pathological conditions. ..
  21. PPAR gamma Signaling and Lung Fibroblast Transdifferentiation
    Virender Rehan; Fiscal Year: 2009
    ..abstract_text> ..
  22. Bisphenol-A and the Reproductive Dysfunction
    Vasantha Padmanabhan; Fiscal Year: 2008
    ..The findings will be relevant to research on fetal origin of infertility and the threat estrogenic environmental disruptors at current exposure levels pose to human health. ..
  23. Prenatal Depression and a Yoga Intervention
    Tiffany M Field; Fiscal Year: 2010
    ..We would expect that yoga would decrease depression, increase vagal activity, decrease cortisol and increase gestational age (decrease prematurity). ..
  24. Fetal Programming of Early Development
    CURT ALAN SANDMAN; Fiscal Year: 2010
    ..Prenatal influences of CRH on HPA reactivity (Aim 4) will be evaluated by assessing salivary cortisol at rest and after mild stress. These studies in children are the first to examine the role of prenatal CRH on human development. ..
  25. Nitrates, Nitrites, and Nitrosatable Drugs and Risk of Selected Birth Defects
    JEAN DIANE BRENDER; Fiscal Year: 2010
    ..The study is also designed to examine whether higher intakes of vitamin C or E decrease these potential risks. ..
  26. Emergence of SIB in Developmentally Delayed Individuals
    CURT ALAN SANDMAN; Fiscal Year: 2010
    ..Findings from this project will contribute to the understanding of the emergence and maintenance of SIB. ..
  27. Maternal overnutrition and offspring fat mass, metabolic and vascular function.
    Debbie Lawlor; Fiscal Year: 2009
    ....
  28. Endocrine Disruptors and Fetal Development
    Vasantha Padmanabhan; Fiscal Year: 2010
    ....
  29. Hormonal Influences on Neural/Behavioral Development
    Melissa Hines; Fiscal Year: 2009
    ..Finally, the research will further basic scientific understanding of the roles of hormones and social/cognitive processes in childrens acquisition of gender role behavior. ..
  30. PB-Environmental Stress Interactions: Re-evaluating Risk
    Deborah Cory Slechta; Fiscal Year: 2009
    ..If Pb alters corticosterone and stress responsiveness, it could also modulate susceptibility to disease and dysfunction. ..
  31. Resilience in Children
    Barry Lester; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  32. Massaging Preterm Infants Enhances Growth
    Tiffany Field; Fiscal Year: 2006
    ..abstract_text> ..
  33. Maternal Stress and Fetal/Infant Development
    Curt Sandman; Fiscal Year: 2006
    ..abstract_text> ..
  34. BEHAVIORAL TOXICITY OF LEAD--A PHARMACOLOGICAL ANALYSIS
    Deborah Cory Slechta; Fiscal Year: 2004
    ..They will further define the comparative roles of NMDA and AMPA/kainate receptors in these projections and their interactions with DA systems, allowing rational behavioral and therapeutic approaches to mesolimbic system dysfunctions. ..
  35. Winter Neuropeptides Conference
    Curt Sandman; Fiscal Year: 2004
    ..The conference is inclusive for all groups. Half of the organizing and steering committees are women. Efforts are made to include minorities and persons with disabilities. ..
  36. MATERNAL SUBSTANCE ABUSE--OUTCOME AT SCHOOL AGE
    Claire Coles; Fiscal Year: 2002
    ..The results of these studies will provide insight into the impact of factors associated with MSA on school-age outcomes. ..
  37. BAEP SCREENING OF NEONATES
    MICHAEL CHURCH; Fiscal Year: 2001
    ..This proposal will address these issues as well. Potentially confounding variables will be gathered and their influence assessed and statistically controlled. Appropriate clinical interventions for mother and infant will be made. ..
  38. STRESS AND BIRTH OUTCOMES
    Curt Sandman; Fiscal Year: 2001
    ..The study design and analytic methods allows for estimation of the unique effects of CRH and psychosocial stress on the length of gestation. ..
  39. Prenatal Exposure to Alcohol and Motor Timing Behavior
    Roger Simmons; Fiscal Year: 2005
    ..abstract_text> ..
  40. NEUROENDOCRINE CONTROL OF FSH
    Vasantha Padmanabhan; Fiscal Year: 2001
    ....
  41. COMBINED AGRICHEMICAL EXPOSURES AND PARKINSON'S DISEASE
    Deborah Cory Slechta; Fiscal Year: 2004
    ....
  42. Reproductive Consequences of Prenatal Androgenization
    Vasantha Padmanabhan; Fiscal Year: 2005
    ..Specifically it will establish that discrete, experimentally induced androgen excess of fetal sheep provides the first clear etiology for hyperandrogenic anovulation in adulthood. ..
  43. PERINATAL AZT: BEHAVIORAL EFFECTS IN A RAT MODEL
    Diana Dow Edwards; Fiscal Year: 2002
    ....
  44. Three-generation Human Study of Reproductive Effects of Marine Food Contaminants
    PHILIPPE ADAM GRANDJEAN; Fiscal Year: 2010
    ..Current evidence already suggests that these pathologies may already affect many populations, and the present proposal aims at identifying whether persistent organochlorine pollutants contribute to these abnormalities. ..
  45. Fetal and Infant Neurobehavior in Opiate Dependent Women
    Lauren Jansson; Fiscal Year: 2009
    ..Information gained from this proposal has the potential to significantly impact the way in which we treat the difficult and high-risk population of opiate dependent pregnant women. ..
  46. A LONGITUDINAL STUDY OF LEAD EXPOSURE AND DENTAL CARIES
    Gene Watson; Fiscal Year: 2003
    ..abstract_text> ..
  47. National Assessment of the Mortality and Morbidity Effects of Tropospheric Ozone
    Michelle L Bell; Fiscal Year: 2010
    ..The goal of this work is to provide policy-makers, scientists, and the public with a better understanding of how ozone affects health in order to aid more effective decisions regarding protection of human health. ..
  48. Ovarian Primordial Follicle Development
    Michael K Skinner; Fiscal Year: 2010
    ..abstract_text> ..
  49. INDUCED ABORTION AND BREAST CANCER RISK
    De Kun Li; Fiscal Year: 2001
    ....
  50. Early brain development after prenatal "Ice" exposure: A Longitudinal MR study
    Linda Chang; Fiscal Year: 2009
    ..Detailed maternal drug use, psychosocial and mood evaluations will be performed and correlated with biological brain changes in these children. ..
  51. Health Effects of Lifetime Exposure to Food Contaminants
    Philippe Grandjean; Fiscal Year: 2009
    ..The results may therefore provide new information that could very likely have an impact on the preventive efforts and standard-setting of the EPA and other regulatory agencies in the U.S and elsewhere. ..
  52. NEURODEVELOPMENTAL OUTCOME OF IN UTERO COCAINE EXPOSURE
    Emmalee Bandstra; Fiscal Year: 2006
    ..AIM 3: To estimate the ameliorating or exacerbating effects of the caregiving, family, and community environment on neuropsychological, educational, and emotional/behavioral outcomes, and onset of high risk behaviors. ..
  53. Developmental Outcomes of Prenatal Exposure to MDMA ('E*
    Lynn Singer; Fiscal Year: 2005
    ....
  54. Mechanisms by which GDM Leads to Diabetes in Offspring
    Rebecca Simmons; Fiscal Year: 2005
    ..non-F2 animals. ..
  55. Low-Level Prenatal Lead Exposure and Retinal Toxicity
    Donald Fox; Fiscal Year: 2009
    ....
  56. Exposure to Bisphenol A & Reproductive Effect in Humans
    De Kun Li; Fiscal Year: 2007
    ..The proposed study will evaluate the reproductive effects of BPA in settings where there have been high levels of exposure. The study will also investigate effects in multiple human generations. ..
  57. Maternal Lifestyle Study Phase 4
    Henrietta Bada; Fiscal Year: 2006
    ..Understanding the consequences of prenatal cocaine exposure and risky environments is crucial for treatment and public policy. [unreadable] [unreadable] [unreadable]..
  58. FAS, SIDS and Stillbirths in Cape Town, South Africa
    Sandra Jacobson; Fiscal Year: 2004
    ..abstract_text> ..
  59. Prenatal MF Exposure & Miscarriage Risk Among Women
    De Kun Li; Fiscal Year: 2009
    ..The findings from the proposed study will provide much needed confirmation of the recently reported results and advance our understanding of a MF health effect. ..
  60. In Utero Organochlorine Exposure & Breast Density
    BARBARA COHN; Fiscal Year: 2009
    ..These women have not yet achieved the age of high breast cancer risk. The proposed project is an efficient use of existing resources for a unique 40-year follow-up study. ..
  61. Pre- and peri-natal predictors of childhood obesity
    Matthew Gillman; Fiscal Year: 2009
    ..The results of this study promise to unravel some knotty epidemiologic issues in the early origins of obesity, and to open up new potential avenues for primordial obesity prevention. ..
  62. MATERNAL ALCOHOL IMPAIRS FETAL ALVEOLAR MACROPHAGE
    THERESA GAUTHIER; Fiscal Year: 2002
    ..Understanding the modulatory role of GSH availability in AM function will broaden our understanding of GSH supplements not only as a possible therapy for infants exposed to ETOH in utero but premature infants in general. ..
  63. Early Life Infection, Neuroinflammation, and Memory
    Staci D Bilbo; Fiscal Year: 2010
    ....
  64. AMELIORATION OF FETAL ALCOHOL EFFECTS
    JOHN HANNIGAN; Fiscal Year: 2004
    ..The results could have direct implications for the development of effective and appropriate treatments for FAS/ARNDs in children. ..
  65. Advanced Reproductive Age and Environmental Health
    Stephanie Engel; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  66. Prenatal Virally Induced Brain Disorder in Mouse
    SEYYED FATEMI; Fiscal Year: 2009
    ..In addition, it is expected that the results will provide clues that will lead to fundamental advances in our knowledge of the pathogenesis of schizophrenia and, therefore, of how it can be prevented and treated. ..
  67. Chemokine Blockade to Preserve Lung Development
    Richard Auten; Fiscal Year: 2005
    ..Aim 3 will determine whether blockade of leukocyte function can safely preserve normal alveolar development during recovery from severe oxidant stress. ..
  68. New DHFR Deletion Polymorphism - A Risk Factor for SB?
    William Johnson; Fiscal Year: 2003
    ..Forms of foliate that are already reduced could be preferable as foliate supplements during pregnancy for prevention of SB. ..
  69. Occupational Exposure to Chlorinated Solvents and Cardiovascular Malformations
    Leila Jackson; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  70. MONITORING METHAMPHETAMINE ABUSE TREATMENT WITH 1H MRS
    Linda Chang; Fiscal Year: 2001
    ..This comprehensive approach will allow us to determine the relationship between changes in cognitive function and metabolite changes in brain tissue associated with chronic methamphetamine abuse and treatment. ..
  71. Effects of Dioxin on Vietnamese Civilians
    David Carpenter; Fiscal Year: 2004
    ..7. ..