pre eclampsia

Summary

Summary: A complication of PREGNANCY, characterized by a complex of symptoms including maternal HYPERTENSION and PROTEINURIA with or without pathological EDEMA. Symptoms may range between mild and severe. Pre-eclampsia usually occurs after the 20th week of gestation, but may develop before this time in the presence of trophoblastic disease.

Top Publications

  1. pmc Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia
    Sharon E Maynard
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Clin Invest 111:649-58. 2003
  2. ncbi Pre-eclampsia
    Baha Sibai
    Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML 0526, Cincinnati, OH 45267, USA
    Lancet 365:785-99. 2005
  3. ncbi Latest advances in understanding preeclampsia
    Christopher W Redman
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Science 308:1592-4. 2005
  4. ncbi Circulating angiogenic factors and the risk of preeclampsia
    Richard J Levine
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Department of Health and Human Services, Bethesda, MD 20892, USA
    N Engl J Med 350:672-83. 2004
  5. pmc Risk factors for pre-eclampsia at antenatal booking: systematic review of controlled studies
    Kirsten Duckitt
    Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Oxford OX3 9DU
    BMJ 330:565. 2005
  6. ncbi Soluble endoglin and other circulating antiangiogenic factors in preeclampsia
    Richard J Levine
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Department of Health and Human Services, Bethesda, MD 20892, USA
    N Engl J Med 355:992-1005. 2006
  7. ncbi Endovascular trophoblast invasion: implications for the pathogenesis of intrauterine growth retardation and preeclampsia
    Peter Kaufmann
    Department of Anatomy II, University of Technology Aachen, D 52057 Aachen, Germany
    Biol Reprod 69:1-7. 2003
  8. ncbi Soluble endoglin contributes to the pathogenesis of preeclampsia
    Shivalingappa Venkatesha
    Center for Vascular Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Nat Med 12:642-9. 2006
  9. pmc Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success
    Susan E Hiby
    Department of Pathology, University of Cambridge, Cambridge CB2 1QP, England, UK
    J Exp Med 200:957-65. 2004
  10. ncbi Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: a randomised placebo-controlled trial
    Douglas Altman
    Lancet 359:1877-90. 2002

Detail Information

Publications360 found, 100 shown here

  1. pmc Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia
    Sharon E Maynard
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Clin Invest 111:649-58. 2003
    ..These observations suggest that excess circulating sFlt1 contributes to the pathogenesis of preeclampsia...
  2. ncbi Pre-eclampsia
    Baha Sibai
    Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML 0526, Cincinnati, OH 45267, USA
    Lancet 365:785-99. 2005
    ..We review findings on the diagnosis, risk factors, and pathogenesis of pre-eclampsia and the present status of its prediction, prevention, and management...
  3. ncbi Latest advances in understanding preeclampsia
    Christopher W Redman
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Science 308:1592-4. 2005
    ..This brief review on preeclampsia does not cover all aspects of this intriguing condition but focuses on some new and interesting findings...
  4. ncbi Circulating angiogenic factors and the risk of preeclampsia
    Richard J Levine
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Department of Health and Human Services, Bethesda, MD 20892, USA
    N Engl J Med 350:672-83. 2004
    ..Limited data suggest that excess circulating soluble fms-like tyrosine kinase 1 (sFlt-1), which binds placental growth factor (PlGF) and vascular endothelial growth factor (VEGF), may have a pathogenic role...
  5. pmc Risk factors for pre-eclampsia at antenatal booking: systematic review of controlled studies
    Kirsten Duckitt
    Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Oxford OX3 9DU
    BMJ 330:565. 2005
    ..To determine the risk of pre-eclampsia associated with factors that may be present at antenatal booking...
  6. ncbi Soluble endoglin and other circulating antiangiogenic factors in preeclampsia
    Richard J Levine
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Department of Health and Human Services, Bethesda, MD 20892, USA
    N Engl J Med 355:992-1005. 2006
    ..Since soluble endoglin, another antiangiogenic protein, acts together with sFlt1 to induce a severe preeclampsia-like syndrome in pregnant rats, we examined whether it is associated with preeclampsia in women...
  7. ncbi Endovascular trophoblast invasion: implications for the pathogenesis of intrauterine growth retardation and preeclampsia
    Peter Kaufmann
    Department of Anatomy II, University of Technology Aachen, D 52057 Aachen, Germany
    Biol Reprod 69:1-7. 2003
    ..e., the placental bed...
  8. ncbi Soluble endoglin contributes to the pathogenesis of preeclampsia
    Shivalingappa Venkatesha
    Center for Vascular Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Nat Med 12:642-9. 2006
    ..Our results suggest that sEng may act in concert with sFlt1 to induce severe preeclampsia...
  9. pmc Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success
    Susan E Hiby
    Department of Pathology, University of Cambridge, Cambridge CB2 1QP, England, UK
    J Exp Med 200:957-65. 2004
    ..In light of our findings, reproductive success may have been a factor in the evolution and maintenance of human HLA-C and KIR polymorphisms...
  10. ncbi Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: a randomised placebo-controlled trial
    Douglas Altman
    Lancet 359:1877-90. 2002
    ..Anticonvulsants are used for pre-eclampsia in the belief they prevent eclamptic convulsions, and so improve outcome. Evidence supported magnesium sulphate as the drug to evaluate...
  11. ncbi Pathogenesis and genetics of pre-eclampsia
    J M Roberts
    Magee-Womens Research Institute, Pittsburgh, PA, USA
    Lancet 357:53-6. 2001
    ..There are genetic components to susceptibility, but the relative contributions of maternal and fetal genotypes are still unclear. Whole-genome mapping could ultimately define the causative genes...
  12. doi Placental origins of preeclampsia: challenging the current hypothesis
    Berthold Huppertz
    Institute of Cell Biology, Histology and Embryology, Center of Molecular Medicine, Medical University Graz, Harrachgasse 21 7, 8010 Graz, Austria
    Hypertension 51:970-5. 2008
  13. ncbi Diagnosis and management of gestational hypertension and preeclampsia
    Baha M Sibai
    Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0526, USA
    Obstet Gynecol 102:181-92. 2003
    ..There is also a need to conduct a randomized trial to determine the benefits and risks of magnesium sulfate during labor and postpartum in women with mild preeclampsia...
  14. pmc Hypertensive diseases of pregnancy and risk of hypertension and stroke in later life: results from cohort study
    Brenda J Wilson
    Department of Public Health, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD
    BMJ 326:845. 2003
    ..To examine the association between hypertensive diseases of pregnancy (gestational hypertension and pre-eclampsia) and the development of circulatory diseases in later life...
  15. pmc Pre-eclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta-analysis
    Leanne Bellamy
    Imperial College School of Medicine, London
    BMJ 335:974. 2007
    ..To quantify the risk of future cardiovascular diseases, cancer, and mortality after pre-eclampsia...
  16. ncbi Recent Insights into the pathogenesis of pre-eclampsia
    J M Roberts
    Magee Womens Research Institute and Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA 15213 3180, USA
    Placenta 23:359-72. 2002
    ..Finally, the suggestion that some of the maternal alterations are due to fetal adaptive responses encourages careful choices of agents and meticulous infant follow up in well planned clinical trials...
  17. ncbi Preeclampsia: recent insights
    James M Roberts
    Magee Womens Research Institute, University of Pittsburgh, Pennsylvania, USA
    Hypertension 46:1243-9. 2005
    ..In the last decade such studies have provided valuable insights into pathophysiology that now guide ongoing clinical trials...
  18. ncbi Microarray analysis of differentially expressed fetal genes in placental tissue derived from early and late onset severe pre-eclampsia
    H Nishizawa
    Department of Obstetrics and Gynecology, Fujita Health University, Toyoake, Japan
    Placenta 28:487-97. 2007
    ..Our data are likely to be a useful future resource in the elucidation of the disease-process and in the identification of novel markers for pre-eclampsia...
  19. pmc Long term mortality of mothers and fathers after pre-eclampsia: population based cohort study
    H U Irgens
    Medical Birth Registry of Norway, Locus for Registry Based Epidemiology, Department of Public Health, University of Bergen, Haukeland Hospital, N5021 Bergen, Norway
    BMJ 323:1213-7. 2001
    ..To assess whether mothers and fathers have a higher long term risk of death, particularly from cardiovascular disease and cancer, after the mother has had pre-eclampsia...
  20. ncbi Dysregulation of the circulating and tissue-based renin-angiotensin system in preeclampsia
    Florian Herse
    Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum, Berlin, Germany
    Hypertension 49:604-11. 2007
    ..We also showed that AT1 autoantibodies cross the ureteroplacental barrier. These components could participate in the pathophysiology of preeclampsia...
  21. ncbi Pre-eclampsia, the placenta and the maternal systemic inflammatory response--a review
    C W G Redman
    Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Placenta 24:S21-7. 2003
    ..Hence the MSIR, by causing maternal insulin resistance, may have substantial foetal advantages so long as it is not too severe...
  22. ncbi Candidate-gene association study of mothers with pre-eclampsia, and their infants, analyzing 775 SNPs in 190 genes
    Katrina A B Goddard
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA
    Hum Hered 63:1-16. 2007
    ..Identification of the genetic regulators of PE may have broader implications, since women with PE are at increased risk of death from cardiovascular diseases later in life...
  23. ncbi First trimester placental growth factor and soluble fms-like tyrosine kinase 1 and risk for preeclampsia
    Ravi Thadhani
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 89:770-5. 2004
    ..7-fold (95% confidence interval, 2.3-351.0) in the third (<12 pg/ml) compared with the first (>39 pg/ml) PlGF tertile. First trimester serum levels of PlGF and sFlt1 may identify women at high risk for PE...
  24. ncbi Cytotrophoblasts up-regulate soluble fms-like tyrosine kinase-1 expression under reduced oxygen: an implication for the placental vascular development and the pathophysiology of preeclampsia
    Takeshi Nagamatsu
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Endocrinology 145:4838-45. 2004
    ..The presented findings might provide a framework with which to understand the mechanism of uterine vascular remodeling and its perturbations as exemplified in preeclampsia...
  25. ncbi ACOG practice bulletin on diagnosing and managing preeclampsia and eclampsia. American College of Obstetricians and Gynecologists
    Barrett M Schroeder
    Am Fam Physician 66:330-1. 2002
  26. pmc The two stage model of preeclampsia: variations on the theme
    J M Roberts
    Magee Womens Research Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Placenta 30:S32-7. 2009
    ..The modified Two Stage Model provides a useful guide towards investigating pathophysiology and guiding therapy...
  27. pmc Autoantibody from women with preeclampsia induces soluble Fms-like tyrosine kinase-1 production via angiotensin type 1 receptor and calcineurin/nuclear factor of activated T-cells signaling
    Cissy Chenyi Zhou
    Department of Biochemistry and Molecular Biology, Medical School, University of Birmingham, Edgbaston, Birmingham, West Midlands, United Kingdom
    Hypertension 51:1010-9. 2008
    ..These autoantibodies represent potentially important targets for diagnosis and therapeutic intervention...
  28. ncbi Early and late preeclampsia: two different maternal hemodynamic states in the latent phase of the disease
    Herbert Valensise
    Department of Obstetrics and Gynecology, Tor Vergata University, Rome, Italy
    Hypertension 52:873-80. 2008
    ....
  29. pmc Placental system A amino acid transport is reduced in pregnancies with small for gestational age (SGA) infants but not in preeclampsia with SGA infants
    E Shibata
    Magee Womens Research Institute, University of Pittsburgh School of Medicine, 204 Craft Avenue, Pittsburgh, PA 15213, USA
    Placenta 29:879-82. 2008
    ....
  30. ncbi Urinary angiogenic factors cluster hypertensive disorders and identify women with severe preeclampsia
    Catalin S Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Science, Yale University, New Haven, CT 06520, USA
    Am J Obstet Gynecol 192:734-41. 2005
    ..We sought to identify whether similar alterations in urinary levels of these proteins cluster hypertensive disorders in pregnancy, and identify women with severe preeclampsia (sPE)...
  31. ncbi Quad screen as a predictor of adverse pregnancy outcome
    Lorraine Dugoff
    Department of Obstetrics and Gynecology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Obstet Gynecol 106:260-7. 2005
    ....
  32. ncbi Excess syncytiotrophoblast microparticle shedding is a feature of early-onset pre-eclampsia, but not normotensive intrauterine growth restriction
    D Goswami
    Department of Obstetrics and Gynaecology, University of British Columbia, 4500 Oak Street, Vancouver BC V6H 3N1, Canada
    Placenta 27:56-61. 2006
    ..Similar placental pathology occurs in some cases of normotensive intrauterine growth restriction (nIUGR), but in the absence of maternal disease...
  33. ncbi Depression and anxiety in early pregnancy and risk for preeclampsia
    T Kurki
    Department of Obstetrics and Gynecology, University Central Hospital of Helsinki, Helsinki, Finland
    Obstet Gynecol 95:487-90. 2000
    ..To examine whether depression and anxiety in early pregnancy are associated with preeclampsia in an unselected nulliparous population...
  34. pmc Prepregnancy cardiovascular risk factors as predictors of pre-eclampsia: population based cohort study
    Elisabeth Balstad Magnussen
    Department of Public Health, Faculty of Medicine, Norwegian University of Science and Technology, N 7489 Trondheim, Norway
    BMJ 335:978. 2007
    ..To examine the effect of cardiovascular risk factors before pregnancy on risk of pre-eclampsia...
  35. pmc The placental problem: linking abnormal cytotrophoblast differentiation to the maternal symptoms of preeclampsia
    Susan J Fisher
    Department of Stomatology, University of California San Francisco, San Francisco, California, USA
    Reprod Biol Endocrinol 2:53. 2004
    ..The current challenge is to build on this knowledge to design clinically useful tests for predicting, diagnosing and treating this dangerous disorder...
  36. ncbi Apoptosis and its role in the trophoblast
    Berthold Huppertz
    Department of Anatomy II, University Hospital RWTH, Aachen, Germany
    Am J Obstet Gynecol 195:29-39. 2006
    ..This review summarizes recent findings on trophoblast apoptosis in normal and pathologic pregnancies...
  37. ncbi Soluble adhesion molecule profile in normal pregnancy and pre-eclampsia
    T Chaiworapongsa
    Perinatology Research Branch, National Institute of Child Health and Human Development, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 12:19-27. 2002
    ..The objective of this study was to determine whether normal pregnancy and pre-eclampsia were associated with changes in the concentrations of soluble selectins and members of the immunoglobulin superfamily of adhesion molecules...
  38. ncbi Inflammation and pre-eclampsia
    A M Borzychowski
    Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Semin Fetal Neonatal Med 11:309-16. 2006
    ..While clinical management of pre-eclampsia does not currently include anti-inflammatory agents, current research is focusing on ways to reduce inflammation and oxidative stress...
  39. pmc Nuclear factor-kappa B, p38, and stress-activated protein kinase mitogen-activated protein kinase signaling pathways regulate proinflammatory cytokines and apoptosis in human placental explants in response to oxidative stress: effects of antioxidant vitam
    Tereza Cindrova-Davies
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
    Am J Pathol 170:1511-20. 2007
    ..Most of these effects are mediated through the p38 MAPK and nuclear factor-kappaB pathways and can be effectively blocked by vitamins C and E in vitro...
  40. ncbi Plasma total homocysteine, pregnancy complications, and adverse pregnancy outcomes: the Hordaland Homocysteine study
    S E Vollset
    Section for Medical Statistics, The Department of Public Health and Primary Health Care, Norway
    Am J Clin Nutr 71:962-8. 2000
    ..Total homocysteine (tHcy) measured in serum or plasma is a marker of folate status and a risk factor for cardiovascular disease...
  41. ncbi Maternal periodontal disease is associated with an increased risk for preeclampsia
    Kim A Boggess
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Obstet Gynecol 101:227-31. 2003
    ..To determine if maternal periodontal disease is associated with the development of preeclampsia...
  42. ncbi Preeclampsia and the risk of end-stage renal disease
    Bjørn Egil Vikse
    Renal Research Group, Institute of Medicine, Haukeland University Hospital, Bergen 5021, Norway
    N Engl J Med 359:800-9. 2008
    ..It is unknown whether preeclampsia is a risk marker for subsequent end-stage renal disease (ESRD)...
  43. ncbi Summary of the NHLBI Working Group on Research on Hypertension During Pregnancy
    James M Roberts
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Hypertens Pregnancy 22:109-27. 2003
    ..Recommendations to increase participation in this research are also presented...
  44. ncbi Maternal body mass index and the risk of preeclampsia: a systematic overview
    Tara E O'Brien
    Division of Obstetrical Medicine, Department of Medicine, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
    Epidemiology 14:368-74. 2003
    ..We performed a systematic overview of the literature to determine the association between prepregnancy body mass index and the risk of preeclampsia...
  45. ncbi The role of the immune system in preeclampsia
    Shigeru Saito
    Department of Obstetrics and Gynecology, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Mol Aspects Med 28:192-209. 2007
    ..Furthermore, the immunoregulatory system is down-regulated in preeclampsia and persistent inflammation reduces regulatory T cell function. Therefore, systematical immunoactivation may be one cause of preeclampsia...
  46. ncbi Sequential changes in antiangiogenic factors in early pregnancy and risk of developing preeclampsia
    Sarosh Rana
    Maternal Fetal Medicine Division, Women and Infants Hospital, Brown University, Providence, RI, USA
    Hypertension 50:137-42. 2007
    ..In conclusion, sequential changes in antiangiogenic factors during early pregnancy may be useful for predicting preterm preeclampsia...
  47. pmc Pregnancy complications and outcomes among overweight and obese nulliparous women
    J M Baeten
    Department of Epidemiology, University of Washington, 325 Ninth Ave, Box 359909, Seattle, WA 98104 2499, USA
    Am J Public Health 91:436-40. 2001
    ..This study examined the associations between prepregnancy weight and the risk of pregnancy complications and adverse outcomes among nulliparous women...
  48. ncbi Diagnosis, prevention, and management of eclampsia
    Baha M Sibai
    Department of Obstetrics and Gynecology, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    Obstet Gynecol 105:402-10. 2005
    ..Recommendations for diagnosis, prevention, management, and counseling of these women are provided based on results of recent studies and my own clinical experience...
  49. pmc A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for
    Roberto Romero
    Perinatology Research Branch, National Institute of Child Health and Human Development, NIH DHHS, Bethesda, MD 20892, USA
    J Matern Fetal Neonatal Med 21:9-23. 2008
    ....
  50. pmc Use of uterine artery Doppler ultrasonography to predict pre-eclampsia and intrauterine growth restriction: a systematic review and bivariable meta-analysis
    Jeltsje S Cnossen
    Department of General Practice, Academic Medical Center, Amsterdam, The Netherlands
    CMAJ 178:701-11. 2008
    ..We investigated the predictive accuracy of all uterine artery Doppler indices for both conditions in the first and second trimesters...
  51. ncbi Negative regulation of soluble Flt-1 and soluble endoglin release by heme oxygenase-1
    Melissa Cudmore
    Department of Reproductive and Vascular Biology, Medical School, University of Birmingham, Edgbaston, Birmingham, West Midlands, B15 2TT, UK
    Circulation 115:1789-97. 2007
    ..Thus, we hypothesized that HO-1 upregulation may offer protection against preeclampsia by inhibiting sFlt-1 and sEng release...
  52. ncbi Summary of the NHLBI Working Group on Research on Hypertension During Pregnancy
    James M Roberts
    Department of Obstetrics, Gynecology and Reproductive Sciences, Graduate School of Public Health, University of Pittsburgh, and Magee Womens Research Institute, Pittsburgh, PA, USA
    Hypertension 41:437-45. 2003
    ..Recommendations to increase participation in this research are also presented...
  53. ncbi Preeclampsia in the parous woman: who is at risk?
    Dorothea Mostello
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology and Women s Health, School of Medicine, St Louis University, USA
    Am J Obstet Gynecol 187:425-9. 2002
    ..The purpose of this study was to identify risk factors for preeclampsia in second pregnancies and to determine whether gestational age at delivery in the first pregnancy increases the risk of recurrent preeclampsia...
  54. ncbi Uteroplacental ischemia results in proteinuric hypertension and elevated sFLT-1
    A Makris
    Vascular Immunology Laboratory, Heart Research Institute and University of Sydney, NSW, Australia
    Kidney Int 71:977-84. 2007
    ....
  55. ncbi Circulating microparticles: a marker of procoagulant state in normal pregnancy and pregnancy complicated by preeclampsia or intrauterine growth restriction
    Florence Bretelle
    Service de Gynecologie Obstetrique, Pr B Blanc, Centre Hospitalo Universitaire de la Conception, Marseille, France
    Thromb Haemost 89:486-92. 2003
    ..In pregnancies with vascular complications, circulating MP with procoagulant potential may be part of the exacerbation of these responses...
  56. ncbi Microarray analysis of differentially expressed genes in placental tissue of pre-eclampsia: up-regulation of obesity-related genes
    T Reimer
    Department of Obstetrics and Gynaecology and Institute of Immunology, University of Rostock, Germany
    Mol Hum Reprod 8:674-80. 2002
    ..In the case of feto-maternal contribution of polymorphic genes to pre-eclampsia, expression analysis of placental tissue has lead to numerous target genes waiting for large scale genetic linkage analyses...
  57. ncbi Priming and remodelling of human placental bed spiral arteries during pregnancy--a review
    F Lyall
    University of Glasgow, Maternal and Fetal Medicine Section, Institute of Medical Genetics, Yorkhill, Glasgow, G3 8SJ, UK
    Placenta 26:S31-6. 2005
    ....
  58. pmc Potential markers of preeclampsia--a review
    Simon Grill
    Laboratory for Prenatal Medicine and Gynecologic Oncology, Department of Biomedicine, University Hospital of Basel, Basel, Switzerland
    Reprod Biol Endocrinol 7:70. 2009
    ..We present here the current knowledge on the biology of preeclampsia and review several biochemical markers which may be used to monitor preeclampsia in a future, that, we hope, is not to distant from today...
  59. ncbi Pregnancy complications and maternal risk of ischaemic heart disease: a retrospective cohort study of 129,290 births
    G C Smith
    Department of Obstetrics and Gynaecology, University of Glasgow, Glasgow, UK
    Lancet 357:2002-6. 2001
    ..One hypothesis to explain this association is fetal adaptation to a suboptimum intrauterine environment. We investigated whether pregnancy complications associated with low birthweight are related to risk of subsequent IHD in the mother...
  60. ncbi Pathophysiology of hypertension during preeclampsia linking placental ischemia with endothelial dysfunction
    J P Granger
    Department of Physiology, Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, USA
    Hypertension 38:718-22. 2001
    ..Results from ongoing basic and clinical studies, however, should provide new and important information regarding the physiological mechanisms responsible for the elevation in arterial pressure in women with preeclampsia...
  61. ncbi Angiogenic factors for the prediction of preeclampsia in high-risk women
    Tiffany A Moore Simas
    Department of Obstetrics and Gynecology, University of Massachusetts Medical School UMass Memorial Health Care, Worcester, MA 01605, USA
    Am J Obstet Gynecol 197:244.e1-8. 2007
    ..The objective of the study was to evaluate angiogenic factors for the prediction of preeclampsia in high-risk women...
  62. ncbi Pre-eclampsia
    J J Walker
    Department of Obstetrics and Gynaecology, St James s University Hospital, Leeds, UK
    Lancet 356:1260-5. 2000
    ..With the increasing understanding of the disease process, there have been advances in management, such as antihypertensive therapy, magnesium sulphate, and fluid restriction...
  63. ncbi Selective overexpression of the hypoxia-inducible transcription factor, HIF-2alpha, in placentas from women with preeclampsia
    A Rajakumar
    Department of Obstetrics, University of Pittsburgh School of Medicine and Magee Womens Research Institute, Pittsburgh, PA 15213, USA
    Biol Reprod 64:499-506. 2001
    ..The molecular mechanism(s) of this abnormality as well as the genes affected downstream are currently under investigation. To our knowledge, this is the first report of abnormal HIF-2alpha expression in human disease other than cancer...
  64. ncbi Relationships between maternal plasma leptin, placental leptin mRNA and protein in normal pregnancy, pre-eclampsia and intrauterine growth restriction without pre-eclampsia
    H Laivuori
    Magee Womens Research Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Mol Hum Reprod 12:551-6. 2006
    ..This study suggests that despite similar failed placental bed vascular remodelling in pre-eclampsia and intrauterine growth restriction (IUGR), leptin gene expression is higher only in preterm pre-eclampsia...
  65. ncbi Expression of vascular endothelial growth factor receptors 1, 2 and 3 in placentas from normal and complicated pregnancies
    S Helske
    Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, PL 140, 00290 Helsinki, Finland
    Mol Hum Reprod 7:205-10. 2001
    ..These results suggest that low maternal serum PlGF and increased placental expression of its receptor VEGFR-1 are associated with pre-eclampsia and FGR...
  66. ncbi Plasma soluble vascular endothelial growth factor receptor-1 concentration is elevated prior to the clinical diagnosis of pre-eclampsia
    Tinnakorn Chaiworapongsa
    Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Matern Fetal Neonatal Med 17:3-18. 2005
    ..The purpose of this study was to determine whether the concentrations of sVEGFR-1 in plasma of pre-eclamptic patients change prior to the clinical manifestations of the disease...
  67. pmc The change in concentrations of angiogenic and anti-angiogenic factors in maternal plasma between the first and second trimesters in risk assessment for the subsequent development of preeclampsia and small-for-gestational age
    Offer Erez
    Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 21:279-87. 2008
    ....
  68. ncbi Prediction and prevention of recurrent preeclampsia
    John R Barton
    Division of Maternal Fetal Medicine, Central Baptist Hospital, Lexington, Kentucky, USA
    Obstet Gynecol 112:359-72. 2008
    ..The development of severe gestational hypertension, fetal growth restriction, or recurrent preeclampsia requires maternal hospitalization...
  69. ncbi Increased apoptosis in the syncytiotrophoblast in human term placentas complicated by either preeclampsia or intrauterine growth retardation
    Naonori Ishihara
    Department of Obstetrics and Gynecology, Kobe University School of Medicine, Japan
    Am J Obstet Gynecol 186:158-66. 2002
    ..This study was undertaken to determine whether preeclampsia and intrauterine growth retardation are associated with an increase in placental apoptosis...
  70. ncbi World Health Organisation multicentre randomised trial of supplementation with vitamins C and E among pregnant women at high risk for pre-eclampsia in populations of low nutritional status from developing countries
    J Villar
    Nuffield Department of Obstetrics and Gynaecology, Oxford Maternal and Perinatal Health Institute, Green Templeton College, University of Oxford, Oxford, UK
    BJOG 116:780-8. 2009
    ..To determine if vitamin C and E supplementation in high-risk pregnant women with low nutritional status reduces pre-eclampsia...
  71. pmc The functional role of the renin-angiotensin system in pregnancy and preeclampsia
    R A Irani
    University of Texas Houston Health Science Center, Department of Biochemistry and Molecular Biology, 6431 Fannin Street, MSB 6 200, Houston, TX 77030, USA
    Placenta 29:763-71. 2008
    ..Here we review the functional role of the RAS during pregnancy and the impact of AT1-AA on preeclampsia...
  72. ncbi Genetic effects on the liability of developing pre-eclampsia and gestational hypertension
    H Salonen Ros
    Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden
    Am J Med Genet 91:256-60. 2000
    ..In efforts to identify women with elevated risk of developing pre-eclampsia during pregnancy, a question about family history of pre-eclampsia should be included...
  73. pmc Recurrence of pre-eclampsia across generations: exploring fetal and maternal genetic components in a population based cohort
    Rolv Skjaerven
    Section for Epidemiology and Medical Statistics, Department of Public Health and Primary Health Care, University of Bergen, Norway
    BMJ 331:877. 2005
    ..To assess the impact on risk of pre-eclampsia of genes that work through the mother, and genes of paternal origin that work through the fetus...
  74. ncbi HLA-G, pre-eclampsia, immunity and vascular events
    Philippe Le Bouteiller
    INSERM U563, Centre de Physiopathologie Toulouse Purpan, Bat A, Hopital Purpan, Cedex 3, 31059 Toulouse, France
    J Reprod Immunol 59:219-34. 2003
    ..In view of these different HLA-G properties, we will briefly discuss how defective HLA-G function may contribute to the low trophoblast invasion and vascular abnormalities observed in pre-eclamptic placentas...
  75. ncbi Paradoxical elevation in adiponectin concentrations in women with preeclampsia
    Jane E Ramsay
    Division of Developmental Medicine, University of Glasgow, Glasgow Royal Infirmary University NHS Trust, Glasgow, Scotland
    Hypertension 42:891-4. 2003
    ..Future studies should determine whether adiponectin concentrations help improve prediction of PE...
  76. ncbi Outcomes of subsequent pregnancy after first pregnancy with early-onset preeclampsia
    Bas B van Rijn
    Division of Perinatology and Gynecology, University Medical Center Utrecht, The Netherlands
    Am J Obstet Gynecol 195:723-8. 2006
    ..The aim of this study was to report outcome of subsequent pregnancy after early-onset preeclampsia in first pregnancy, and to evaluate potential risk factors for recurrence of preeclampsia and preterm delivery...
  77. ncbi Severe preeclampsia and high frequency of genetic thrombophilic mutations
    M J Kupferminc
    Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv, Israel
    Obstet Gynecol 96:45-9. 2000
    ..To determine whether severe preeclampsia is associated with genetic thrombophilic mutations or other types of thrombophilia...
  78. ncbi Role of placentally produced inflammatory and regulatory cytokines in pregnancy and the etiology of preeclampsia
    Corinne Rusterholz
    Laboratory for Prenatal Medicine and Gynecologic Oncology, University Women s Hospital Department of Research, University of Basel, Hebelstrasse 20, Basel 4031, Switzerland
    Semin Immunopathol 29:151-62. 2007
    ....
  79. ncbi Expression profile of trophoblast invasion-associated genes in the pre-eclamptic placenta
    Z J Pang
    Department of Obstetrics and Gynecology, Nanfang Hospital, The First Military Medical University, Guangzhou 510515, China
    Br J Biomed Sci 60:97-101. 2003
    ..Results suggest that the abnormal expression profiles of extracellular matrix molecules and degrading proteinases might be associated with the pathogenesis of pre-eclampsia...
  80. ncbi Genetic susceptibility to preeclampsia: roles of cytosineto-thymine substitution at nucleotide 677 of the gene for methylenetetrahydrofolate reductase, 68-base pair insertion at nucleotide 844 of the gene for cystathionine beta-synthase, and factor V Leid
    Y J Kim
    Department of Obstetrics and Gynecology, University of Iowa, Iowa City, USA
    Am J Obstet Gynecol 184:1211-7. 2001
    ....
  81. ncbi How Does the maternal immune system contribute to the development of pre-eclampsia?
    A Moffett
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Placenta 28:S51-6. 2007
    ..The academic excitement of this work is the realisation that this is a novel form of allorecognition based on NK cells that operates entirely differently from self/non-self discrimination used by T cells...
  82. ncbi The role of placental oxidative stress and lipid peroxidation in preeclampsia
    Sajal Gupta
    Center for Advanced Research in Human Reproduction, Infertility, and Sexual Function, Glickman Urological Institute and the Department of Obstetrics Gynecology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Obstet Gynecol Surv 60:807-16. 2005
    ..Additional longitudinal studies are necessary to determine if the various oxidative stress biomarkers estimated early in pregnancy can be narrowed to a single marker for predicting preeclampsia...
  83. ncbi Recombinant vascular endothelial growth factor 121 attenuates hypertension and improves kidney damage in a rat model of preeclampsia
    Zhihe Li
    Scios Inc, Fremont, CA, USA
    Hypertension 50:686-92. 2007
    ..VEGF121 had beneficial effects in this rat model of preeclampsia without apparent harm to the fetus. Further study of VEGF121 as a potential therapeutic agent for preeclampsia is warranted...
  84. pmc Increased sFlt-1 to PlGF ratio in women who subsequently develop preeclampsia
    Shin Young Kim
    Laboratory of Medical Genetics, Cheil General Hospital and Women s Healthcare Center, Kwandong University School of Medicine, Seoul, Korea
    J Korean Med Sci 22:873-7. 2007
    ..Accordingly, the sFlt-1/PlGF ratio may provide early prediction of subsequent development of preeclampsia...
  85. ncbi Gene expression profiling of human placentas from preeclamptic and normotensive pregnancies
    S R Hansson
    Department of Obstetrics and Gynecology, Lund University Hospital, Sweden
    Mol Hum Reprod 12:169-79. 2006
    ....
  86. ncbi Morphometric placental villous and vascular abnormalities in early- and late-onset pre-eclampsia with and without fetal growth restriction
    M Egbor
    Department of Surgical Research, NPIMR, Northwick Park Hospital, Harrow, UK
    BJOG 113:580-9. 2006
    ..To evaluate placental morphology in pregnancies complicated by early- and late-onset pre-eclampsia (PET) with and without fetal growth restriction (FGR) using stereological techniques...
  87. ncbi Divergent trophoblast invasion and apoptosis in placental bed spiral arteries from pregnancies complicated by maternal anemia and early-onset preeclampsia/intrauterine growth restriction
    Mamed Kadyrov
    Department of Anatomy II, University Hospital, Aachen, Germany
    Am J Obstet Gynecol 194:557-63. 2006
    ..We compared trophoblast invasion into spiral arteries in pregnancies with maternal anemia or early-onset preeclampsia/intrauterine growth restriction and related these findings to trophoblast apoptosis...
  88. ncbi Short- and long-term changes in plasma inflammatory markers associated with preeclampsia
    Dilys J Freeman
    Division of Developmental Medicine, University of Glasgow, Glasgow, United Kingdom
    Hypertension 44:708-14. 2004
    ..In conclusion, preeclampsia is associated with short- and long-term changes in inflammatory status...
  89. ncbi Elevated placental soluble vascular endothelial growth factor receptor-1 inhibits angiogenesis in preeclampsia
    Shakil Ahmad
    Department of Reproductive and Vascular Biology, The Medical School, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TG, UK
    Circ Res 95:884-91. 2004
    ..Our finding demonstrates the dysregulation of the VEGF/PlGF axis in preeclampsia and offers an entirely new therapeutic approach to its treatment...
  90. ncbi Human chorionic gonadotropin and testosterone in normal and preeclamptic pregnancies in relation to fetal sex
    Johan Arnt Steier
    Department of Obstetrics and Gynecology, Bergen, Norway
    Obstet Gynecol 100:552-6. 2002
    ..The aim of the present study was to evaluate the effects of fetal gender on serum human chorionic gonadotropin (hCG) and testosterone in normotensive and preeclamptic pregnancies...
  91. ncbi Classic and novel risk factor parameters in women with a history of preeclampsia
    Naveed Sattar
    Department of Pathological Biochemistry, Glasgow Royal Infirmary University NHS Trust, Glasgow G31 2ER UK
    Hypertension 42:39-42. 2003
    ..Rather markedly elevated ICAM-1 concentrations and specific but subtle features of the metabolic syndrome (glucose, blood pressure) are likely to be involved...
  92. ncbi Soluble fms-like tyrosine kinase 1 is increased in preeclampsia but not in normotensive pregnancies with small-for-gestational-age neonates: relationship to circulating placental growth factor
    Eiji Shibata
    Magee Womens Research Institute, University of Pittsburgh, 204 Craft Avenue, Pittsburgh, Pennsylvania 15213, USA
    J Clin Endocrinol Metab 90:4895-903. 2005
    ..However, the latter condition occurs without maternal vascular disease...
  93. ncbi An international trial of antioxidants in the prevention of preeclampsia (INTAPP)
    Hairong Xu
    Department of Obstetrics and Gynecology, Hopital Ste Justine, Universite de Montreal, Montreal, QC, Canada
    Am J Obstet Gynecol 202:239.e1-239.e10. 2010
    ..We sought to investigate whether prenatal vitamin C and E supplementation reduces the incidence of gestational hypertension (GH) and its adverse conditions among high- and low-risk women...
  94. ncbi Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems
    G J Hofmeyr
    University of the Witwatersrand, University of Fort Hare, Eastern Cape Department of Health, Frere and Cecilia Makiwane Hospitals, Private Bag X 9047, East London, Eastern Cape, South Africa 5200
    Cochrane Database Syst Rev 3:CD001059. 2006
    ..Pre-eclampsia and eclampsia are common causes of serious morbidity and death. Calcium supplementation may reduce the risk of pre-eclampsia through a number of mechanisms, and may help to prevent preterm labour...
  95. ncbi Genetic polymorphisms in vasoactive genes and preeclampsia: a meta-analysis
    Igor Medica
    Division of Medical Genetics, Department of Gynecology and Obstetrics, University Clinical Centre, Ljubljana, Slovenia
    Eur J Obstet Gynecol Reprod Biol 131:115-26. 2007
    ..51 (95% CI 1.17, 1.94). No single polymorphism was identified as having a major effect...
  96. ncbi Abortion, changed paternity, and risk of preeclampsia in nulliparous women
    Audrey F Saftlas
    Department of Epidemiology, University of Iowa College of Public Health, Iowa City, IA 52242, USA
    Am J Epidemiol 157:1108-14. 2003
    ..An immune-based etiologic mechanism is proposed, whereby prolonged exposure to fetal antigens from a previous pregnancy protects against preeclampsia in a subsequent pregnancy with the same father...
  97. pmc The pre-eclampsia community guideline (PRECOG): how to screen for and detect onset of pre-eclampsia in the community
    Fiona Milne
    Action on Pre eclampsia, Harrow, Middlesex HA1 4HZ
    BMJ 330:576-80. 2005
  98. pmc Molecular mechanisms of preeclampsia
    Walter P Mutter
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Microvasc Res 75:1-8. 2008
    ..This review will summarize our current understanding of the molecular mechanism of preeclampsia, with an emphasis on the recently characterized circulating anti-angiogenic proteins...
  99. pmc Regulation of monocyte chemoattractant protein-1 expression by tumor necrosis factor-alpha and interleukin-1beta in first trimester human decidual cells: implications for preeclampsia
    Charles J Lockwood
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Am J Pathol 168:445-52. 2006
    ..This finding suggests a mechanism by which recruitment of excess macrophages to the decidua impairs endovascular trophoblast invasion, the primary placental defect of preeclampsia...
  100. ncbi First trimester maternal serum placental protein 13 for the prediction of pre-eclampsia in women with a priori high risk
    Asma Khalil
    Department of Obstetrics and Gynaecology, Queen Mary, University of London, UK
    Prenat Diagn 29:781-9. 2009
    ..To evaluate whether first trimester maternal serum PP13 can predict pre-eclampsia among women with a priori high risk...
  101. ncbi Factor V Leiden is associated with pre-eclampsia but not with fetal growth restriction: a genetic association study and meta-analysis
    T Dudding
    Hunter Genetics, Hunter New England Health Service, NSW, Australia
    J Thromb Haemost 6:1869-75. 2008
    ..These results, however, are conflicting...

Research Grants77

  1. Protein Nitration in the Placenta
    Leslie Myatt; Fiscal Year: 2012
    ....
  2. Predictors of Pregnancy Outcome in SLE and APS
    Jane E Salmon; Fiscal Year: 2012
    ....
  3. Triggers of Abruptio Placentae - A Case Crossover Study of an Ischemic Placental
    Michelle A Williams; Fiscal Year: 2013
    ....
  4. The Role of Decidual Innate Immunity in the Pathogenesis of Preeclampsia
    Se Te Joseph Huang; Fiscal Year: 2012
    ..This study of the immunological basis of preeclampsia will result in new therapies to combat this complication during pregnancy. Hence, the welfare of affected families and society will be considerably improved. ..
  5. Novel Therapy for Preeclampsia
    James W Larrick; Fiscal Year: 2012
    ..Digibind was effective for PE in a clinical trial. We will develop a novel human monoclonal antibody with higher specificity than Digibind for MBG. This innovative therapeutic humAb will be the first effective treatment of PE. ..
  6. Complement Activation in Pregnancy and Hypertension
    Jean F Regal; Fiscal Year: 2013
    ....
  7. The Impact of Sleep-Disordered Breathing on Adverse Pregnancy Outcomes
    LOUISE M O apos BRIEN; Fiscal Year: 2010
    ..This study will ultimately lead to the development of early intervention strategies to treat sleep disordered breathing during pregnancy which may ultimately reduce risk of adverse pregnancy outcome. ..
  8. Health Care Disparities in the Pacific Islands Pacific Regional Medical Conferenc
    SAIED SAFABAKHSH; Fiscal Year: 2011
    ....
  9. Pluripotent human stem cells as models for normal and diseased trophoblast
    ROBERT MICHAEL ROBERTS; Fiscal Year: 2013
    ..Also by generating such pluripotent cells from umbilical cords of babies born to mothers that developed pre-eclampsia, we hope to recreate the cell type that caused the disease in the first place. ..
  10. Apoptosis and Trophoblast Fusion
    NEAL STEWART ROTE; Fiscal Year: 2010
    ..We will investigate those correlations by specifically inhibiting these proteins using peptide inhibitors and gene silencing. Additional studies will evaluate the role of signal transduction through NFB. ..
  11. Trophoblast MHC-I: Trigger for Immune-Mediated Rejection of Cloned Bovine Fetuses
    Kenneth L White; Fiscal Year: 2011
    ....
  12. DHA, Inflammation, and Insulin Sensitivity in Obese Pregnant Women
    Debra Krummel; Fiscal Year: 2009
    ....
  13. Pluripotent Stem Cells: Modeling syncytiotrophoblast development and pathogenesis
    Danny J Schust; Fiscal Year: 2013
    ..We will test this hypothesis in vitro using iPSCs derived from the umbilical cords of babies born to mothers with severe preeclampsia and gestational age-matched control iPSCs. ..
  14. NICHD Maternal Fetal Medicine Units Network
    Geeta K Swamy; Fiscal Year: 2013
    ....
  15. Human Decidual Leukocytes and Their Placental Ligands
    JACK STROMINGER; Fiscal Year: 2009
    ..abstract_text> ..
  16. Vascular Mechanisms in Pregnancy-Induced Hypertension
    Raouf A Khalil; Fiscal Year: 2013
    ....
  17. Autoantibodies in Preeclampsia: Pre-symptomatic markers and therapeutic targets
    Yang Xia; Fiscal Year: 2010
    ..Strategies to prevent or effectively treat preeclampsia would result in healthier babies and healthier mothers. Research proposed here is likely to contribute significantly to this goal. ..
  18. Treatment of Hyperandrogenism vs. Insulin Resistance in Infertile PCOS Women
    Richard S Legro; Fiscal Year: 2012
    ..Our goal is to develop safe and effective treatments to improve the treatment of infertility in women with PCOS, but the findings can be generalized to all women with PCOS. ..
  19. Role of the Renin-Angiotensin system in placental insufficiency
    Eugenia Mata-Greenwood; Fiscal Year: 2013
    ..In addition, the outcomes of this proposal will shed light into the role of RAS genetics in pregnancy outcomes and will provide the scientific community with a novel animal model to study the genetics of placental insufficiency and PE. ..
  20. Prolylcarboxypeptidase is a Risk Factor for Cardiovascular Disease
    Alvin H Schmaier; Fiscal Year: 2013
    ..Up-regulation of PRCP may be a target to protect individuals from cardiovascular disease as manifested by hypertension and arterial thrombosis as seen in stroke and MI. ..
  21. Functional significance of Siglec-6, a novel leptin receptor, in human placental
    Virginia Winn; Fiscal Year: 2013
    ..For the baby, PE can cause growth failure or stillbirth. Those babies that do survive have an increased risk of disorders as adults including diabetes and heart disease. ..
  22. Weight management for improved pregnancy outcomes
    Victor J Stevens; Fiscal Year: 2012
    ..In addition to measures of safety, our secondary analyses will address the feasibility and acceptability of a weight management intervention among obese pregnant women. ..
  23. (INTRODUCTION) MECHANISMS OF ACCLIMATIZATION: FETUS AND ADULT
    Lawrence D Longo; Fiscal Year: 2013
    ....
  24. Angiogenic factors, abnormal placentation and adverse pregnancy outcomes
    Sarosh Rana; Fiscal Year: 2013
    ..The combined expertise of mentors and collaborators provide a unique opportunity for the applicant to achieve the goals of this project and to start a career as an independent investigator. ..
  25. Anti-Phospholipid Multiplex For Pathologic Epitopes
    Paul O Neilsen; Fiscal Year: 2010
    ..This project will help define the biochemical causes of antiphospholipid disorders and improve their diagnosis bringing better understanding and diagnosis to researchers, physicians, and patients. ..
  26. Bone Morphogenic Protein Signaling Pathways in Uterine Biology
    Martin M Matzuk; Fiscal Year: 2013
    ....
  27. Hypertension, Kidney and Pregnancy
    Joey P Granger; Fiscal Year: 2013
    ..Based on preliminary data presented in this application, we propose that induction of hemeoxygenase-1 and its catalytic products, carbon monoxide and bilirubin, may provide a novel therapeutic approach for the treatment of PE. ..
  28. VCU Building Interdisciplinary Research Careers in Women's Health
    Jerome F Strauss; Fiscal Year: 2011
    ....
  29. The Kidney, Hypertension, Pregnancy and Inflammation
    Babbette LaMarca; Fiscal Year: 2013
    ....
  30. Adverse Outcomes of Assisted Reproductive Technologies: Genetics or Epigenetics?
    Margareta Pisarska; Fiscal Year: 2013
    ....
  31. Modeling preeclampsia in mice with inducible placenta-specific gene expression
    Nihar R Nayak; Fiscal Year: 2012
    ....
  32. The Role of Complement in the Pathogenesis of Preeclampsia
    MICHAEL PAUL TRIEBWASSER; Fiscal Year: 2013
    ..Finally, the effect of reperfusion injury in trophoblast cultures on complement activation and trophoblast state cell fate will be quantified and followed over time. ..
  33. The role of T lymphocytes in mediating hypertension during pregnancy
    Kedra L Wallace; Fiscal Year: 2013
    ..To test the hypothesis that Endothelin-1 and ROS facilitate T lymphocyte mediated AT1-AA induced increases blood pressure response to placental ischemia in pregnant rats . ..
  34. Functional Analysis of PAAN-AG5, the Baboon Counterpart of HLA-G5
    Daudi K Langat; Fiscal Year: 2010
    ..This proposal is aimed at assessing the feasibility of using the olive baboon as a model for HLA-G in vivo experiments. ..
  35. Long Term Implications of Preeclampsia: Role of Obesity vs sFlt-1 Overexpression
    Egle Bytautiene; Fiscal Year: 2009
    ..This model will also provide an experimental tool for investigating mechanisms of CVD and the well established gender differences in health and disease. ..
  36. Sex-specific fetal programming of adult vascular dysfunction and hypertension
    KUNJU REDDIAR SATHISH KUMAR; Fiscal Year: 2013
    ....
  37. Human Decidual Leukocytes and Their Placental Ligands
    Jack L Strominger; Fiscal Year: 2013
    ....
  38. Eunice Kennedy Shriver NICHD Maternal Fetal Medicine Units Network
    Edward K Chien; Fiscal Year: 2013
    ..Focusing on significant perinatal and long-term outcomes, we will bring to an end procedures and practices that are ineffective or incur undue risks. ..
  39. CELLULAR MECHANISMS IN THE INDUCTION OF AROMATASE
    Carole R Mendelson; Fiscal Year: 2013
    ..We anticipate that our studies will shed new light on the etiology of this devastating disease. ..
  40. Preeclampsia, IUGR and Hypertension: Targets for Treatment
    Joey P Granger; Fiscal Year: 2013
    ....
  41. Placental shape features, gestational timing and maternal and infant health
    Carolyn M Salafia; Fiscal Year: 2011
    ....
  42. Novel ex-vivo Immunoadsorption Therapy to Treat Preeclampsia
    Woo Joo; Fiscal Year: 2013
    ..The total market for Aggamin's therapeutic product to treat severe early-onset PE cases in the US is estimated at $0.5-1.5 billion. ..
  43. Oxidant Stress Mechanisms in Preeclampsia
    Scott W Walsh; Fiscal Year: 2013
    ....
  44. A Prospective Cohort Study of Migraines, Platelet Activation, and Preeclampsia
    Michelle A Williams; Fiscal Year: 2012
    ....
  45. Role of Maternal Platelets in the Placenta and Pregnancy Complications
    Rashmi Sood; Fiscal Year: 2013
    ..These are much-needed investigations into platelet and coagulation activities at the feto-maternal interface with direct significance for pregnancy disorders. ..
  46. Research Training Prog in Reproductive Biol & Med for Latin American Scientists
    John E Nestler; Fiscal Year: 2010
    ..abstract_text> ..
  47. Metabolic Consequences of bariatric surgery on pregnant and lactating rats and th
    Bernadette E Grayson; Fiscal Year: 2013
    ..Further, the postnatal effects of these procedures on the metabolic health of the offspring will be determined. ..
  48. Maternal Androgen Excess: Vascular and Placental Function and Fetal Consequences
    KUNJU REDDIAR SATHISH KUMAR; Fiscal Year: 2012
    ..Our rat model presents an opportunity to investigate the adverse effects of elevated maternal androgens, which may aid in improving maternal and fetal health. ..
  49. Impact of maternal hyperleptinemia on health: CNS mechanisms
    Rebecca Leshan; Fiscal Year: 2013
    ..Our proposed research will examine the mechanisms by which offspring brains may be metabolically "programmed", with the ultimate goal of identifying new targets for the prevention and treatment of obesity. ..
  50. Structure and Function of Endothelial Fenestrae
    RADU VIRGIL STAN; Fiscal Year: 2010
    ..The techniques employed are cell isolation, fractionation, biochemical assays, cell free-assays, genetically modified animal models, cell culture, transfections, light and electron microscopy. ..
  51. Serine Protease Corin in Pregnancy-induced Hypertension
    Qingyu Wu; Fiscal Year: 2013
    ..In this study, we will try to understand how corin works and if we can develop new corin-based methods to diagnose and treat high blood pressure during pregnancy. 1 ..
  52. Pregnancy complications, future cardiovascular disease risk factors and cardiovas
    NISHA INDRAVADAN PARIKH; Fiscal Year: 2013
    ....
  53. Intrauterine hypoxia induces cytokine gene expression in fetal cardiac ventricles
    LASHAUNA C EVANS; Fiscal Year: 2010
    ..These proposed studies will aid in our understanding of the underlying mechanisms associated with cardioprotection, injury, as well as fetal programming during intrauterine stress. ..
  54. Pro-inflammatory regulation of angiogenic gene expression in human trophoblast
    Donald S Torry; Fiscal Year: 2012
    ..How this imbalance occurs is not known. This application will begin to determine the novel molecular mechanisms responsible for aberrant expression of two prominent pro- and anti-angiogenic factors produced by placental cells. ..
  55. Vitamin D: a link to racial disparities in birth outcomes
    Lisa M Bodnar; Fiscal Year: 2012
    ..Improving vitamin D status in pregnant women may be a simple strategy for reducing the excess cases of adverse birth outcomes among black women in the United States. ..
  56. Evolved placental response to hypoxa
    Stacy Zamudio; Fiscal Year: 2012
    ..This will provide us with a map for the development of clinical tests that detect when babies in utero are not growing normally and to design therapies to improve their growth and long-term health. ..
  57. Fetal Brain Damage: A Placental Disorder
    ANNA PENN; Fiscal Year: 2009
    ....
  58. Mechanisms of Renal Vasodilation by Relaxin
    Kirk P Conrad; Fiscal Year: 2010
    ....
  59. Development of a Yoga Intervention for Antenatal Depression
    Cynthia L Battle; Fiscal Year: 2012
    ..If shown to be effective, yoga could provide depressed women with an option for treatment that may be more acceptable than existing treatments. ..
  60. PPARy and Uterine Vascular Dysfunction in Diabetic Pregnancy
    Natalia I Gokina; Fiscal Year: 2011
    ....
  61. Vasomotor Sympathetic Activity during Early Pregnancy in Humans
    Qi Fu; Fiscal Year: 2010
    ..Results obtained will provide novel insights into how blood pressure is regulated by the sympathetic nervous system during normal pregnancy, particularly during early pregnancy in humans. ..
  62. CD46 AND RISK VARIANTS: EXPANDING ROLES IN DISEASE AND DISSECTING MEMBRANE DYNAMI
    JOHN PATTERSON ATKINSON; Fiscal Year: 2013
    ..Identifying the genetic basis and the inflammatory pathways responsible for these illnesses will allow for targeted therapeutics to prevent and treat the pathologic process. ..
  63. Vascular Angiotensin Type-2 Receptor in Normal and Hypertensive Pregnancy
    Raouf A Khalil; Fiscal Year: 2010
    ....
  64. RENAL FUNCTION AND BLOOD PRESSURE CONTROL IN PREGNANCY
    Edmond Quillen; Fiscal Year: 2000
    ..These studies should improve our understanding to the integrative responses of estrogens, ANF and NO during pregnancy. ..
  65. A Model Statewide Trial to Detect and Treat Maternal Hypothyroidism in Pregnancy
    James Haddow; Fiscal Year: 2009
    ..This approach can eventually be implemented throughout the United States. ..
  66. ROLE OF SEROTONIN IN PREGNANCY-RELATED HYPERTENSION
    Carl Weiner; Fiscal Year: 1992
    ..receptor status? Question 9: Does the combination of serotonin with the other study agents stimulate prostacyclin release above that which would be expected by simply summing the prostacyclin released in response to the individual agents?..
  67. Dissociating hypoxia from pathology in preeclampsia and*
    Stacy Zamudio; Fiscal Year: 2007
    ..The advantage of this unique in vivo model is an unparalleled potential to elucidate the underlying pathological causes of preeclampsia and/or IUGR while controlling for the effects of placental hypoxia. [unreadable] [unreadable]..
  68. Magnesium's Antihypertensive Effects in Preeclampsia
    CYNTHIA STANDLEY; Fiscal Year: 2003
    ..Data derived from these experiments will elucidate the anti-hypertensive effects of magnesium, its mode of action and the roles of NO and magnesium in preeclampsia and pregnancy-induced hypertension. ..
  69. NITRIC OXIDE AND SUPEROXIDE INTERACTIONS IN THE PLACENTA
    Leslie Myatt; Fiscal Year: 2002
    ..5. Expression of mRNA and protein for SOD isoforms, xanthine oxidase and the cytochrome b558 subunit of NADPH oxidase in normal and pathologic placental tissues using RT-PCR and immunohistochemistry. ..
  70. Target regulation of neuronal plasticity
    David Pettigrew; Fiscal Year: 2009
    ..Monica Brauer as an extension of NIH grant #R01NS044972. ..
  71. GLOBAL NETWORK FOR WOMEN'S & CHILDREN'S HEALTH RESEARCH
    Joseph Spinnato; Fiscal Year: 2006
    ..S. investigators will assess the long-term impact of this program on women?s and children?s health research, health care in Brazil, and international research collaboration. ..
  72. GESTATIONAL DIABETES: DIAGNOSTIC CRITERIA AND OUTCOMES
    Assiamira Ferrara; Fiscal Year: 2003
    ....
  73. GENETIC RISK FACTORS OF PREECLAMPSIA AMONG PERUVIAN WOME
    Michelle Williams; Fiscal Year: 2002
    ..The development of preeclampsia screening and prevention strategies may be enhanced by conducting parallel studies involving participants form ethnically/racially, geographically and economically diverse backgrounds. ..
  74. Aspen Perinatal Biology Symposium
    Leslie Myatt; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  75. PREECLAMPSIA LINKAGE TO PLACENTAL IMPLANTATION-PERFUSION
    Robert Taylor; Fiscal Year: 1992
    ..With these studies we hope to identify preeclamptic patients at an early stage, better understand the etiology of the disorder and provide insights which aid rational therapeutic approaches...
  76. Angiotensin (1-7) in Normal and Preeclamptic Pregnancy
    David Merrill; Fiscal Year: 2004
    ..In summary, the ultimate goal of this study is to understand the contribution of both vasodilator and vasoconstrictor components of the RAAS to blood pressure regulation in normal and preeclampsia pregnancy. ..
  77. PPAR Function in human pregnancy and preeclampsia
    Robert Taylor; Fiscal Year: 2005
    ..We anticipate that our multi-faceted approach to elucidate the role of PPAR action in normal pregnancy and PE will provide new clues to the underlying pathophysiology, and ultimately, therapy of PE and its clinical complications. ..