pregnancy induced hypertension

Summary

Summary: A condition in pregnant women with elevated systolic (>140 mm Hg) and diastolic (>90 mm Hg) blood pressure on at least two occasions 6 h apart. HYPERTENSION complicates 8-10% of all pregnancies, generally after 20 weeks of gestation. Gestational hypertension can be divided into several broad categories according to the complexity and associated symptoms, such as EDEMA; PROTEINURIA; SEIZURES; abnormalities in BLOOD COAGULATION and liver functions.

Top Publications

  1. ncbi Pre-pregnancy weight and the risk of stillbirth and neonatal death
    Janni Kristensen
    Perinatal Epidemiological Research Unit, Department of Obstetrics and Gynaecology, Aarhus University Hospital, 8200 Aarhus N, Denmark
    BJOG 112:403-8. 2005
  2. ncbi Prepregnancy body mass index, gestational weight gain, and risk of hypertensive pregnancy among Latina women
    Renée Turzanski Fortner
    Division of Biostatistics and Epidemiology, Department of Public Health, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA 01003 9304, USA
    Am J Obstet Gynecol 200:167.e1-7. 2009
  3. ncbi The relationship between pregnancy induced hypertension and congenital thrombophilia
    S Cansun Demir
    Department of Obstetrics and Gynecology, Faculty of Medicine, Cukurova University Balcali, Adana, Turkey
    Saudi Med J 27:1161-6. 2006
  4. ncbi Association between pregnancy induced hypertension and low birth weight; a population based case-control study
    Latifah A Rahman
    Kedah State Health Office, Ministry of Health, Malaysia
    Asia Pac J Public Health 20:152-8. 2008
  5. ncbi Maternal deaths associated with hypertensive disorders of pregnancy: a population-based study
    J Moodley
    Department of Obstetrics and Gynaecology, Nelson R Mandela School of Medicine, Congella, South Africa
    Hypertens Pregnancy 23:247-56. 2004
  6. ncbi First trimester PAPP-A levels associated with early prediction of pregnancy induced hypertension
    Paolo Meloni
    Department of General Surgery Pietro Valdoni, Policlinico Umberto I, La Sapienza University, Rome, Italy
    Hypertens Pregnancy 28:361-8. 2009
  7. ncbi Study of lipid profile, lipid peroxidation and vitamin E in pregnancy induced hypertension
    Suchanda Sahu
    Department of Biochemistry, Pondicherry Institute of Medical Sciences, Kalapet, Pondicherry 605 014
    Indian J Physiol Pharmacol 53:365-9. 2009
  8. ncbi Hypertensive disorders in pregnancy: a population-based study
    Christine L Roberts
    Centre for Perinatal Health Services Research, University of Sydney, NSW, Australia
    Med J Aust 182:332-5. 2005
  9. ncbi [The relationship between prepregnancy body mass index and the occurrence of pregnancy induced hypertension]
    Ying hui Liu
    Institute of Reproductive and Child Health, Peking University, Beijing 100191, China
    Zhonghua Yu Fang Yi Xue Za Zhi 43:299-304. 2009
  10. pmc The accuracy of reporting of the hypertensive disorders of pregnancy in population health data
    Christine L Roberts
    Clinical and Population Perinatal Health Research, The Kolling Institute of Medical Research, University of Sydney, Sydney, Australia
    Hypertens Pregnancy 27:285-97. 2008

Detail Information

Publications233 found, 100 shown here

  1. ncbi Pre-pregnancy weight and the risk of stillbirth and neonatal death
    Janni Kristensen
    Perinatal Epidemiological Research Unit, Department of Obstetrics and Gynaecology, Aarhus University Hospital, 8200 Aarhus N, Denmark
    BJOG 112:403-8. 2005
    ..To evaluate the association between maternal pre-pregnancy body mass index (BMI) and the risk of stillbirth and neonatal death and to study the causes of death among the children...
  2. ncbi Prepregnancy body mass index, gestational weight gain, and risk of hypertensive pregnancy among Latina women
    Renée Turzanski Fortner
    Division of Biostatistics and Epidemiology, Department of Public Health, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA 01003 9304, USA
    Am J Obstet Gynecol 200:167.e1-7. 2009
    ..Prepregnancy body mass index (BMI) and gestational weight gain have been associated with hypertensive disorders of pregnancy, but previous studies have included few Latinas, a group at increased risk...
  3. ncbi The relationship between pregnancy induced hypertension and congenital thrombophilia
    S Cansun Demir
    Department of Obstetrics and Gynecology, Faculty of Medicine, Cukurova University Balcali, Adana, Turkey
    Saudi Med J 27:1161-6. 2006
    To investigate the relationship between some thrombophilic parameters and pregnancy induced hypertension (PIH).
  4. ncbi Association between pregnancy induced hypertension and low birth weight; a population based case-control study
    Latifah A Rahman
    Kedah State Health Office, Ministry of Health, Malaysia
    Asia Pac J Public Health 20:152-8. 2008
    ..63, 9.71) for low birth weight. There was a significant association of pregnancy-induced hypertension with low birth weight. Women who delivered low birth weight babies were 5 times more likely to have had pregnancy-induced hypertension...
  5. ncbi Maternal deaths associated with hypertensive disorders of pregnancy: a population-based study
    J Moodley
    Department of Obstetrics and Gynaecology, Nelson R Mandela School of Medicine, Congella, South Africa
    Hypertens Pregnancy 23:247-56. 2004
    ..Clear protocols for management of hypertension in pregnancy at all levels of health care are required...
  6. ncbi First trimester PAPP-A levels associated with early prediction of pregnancy induced hypertension
    Paolo Meloni
    Department of General Surgery Pietro Valdoni, Policlinico Umberto I, La Sapienza University, Rome, Italy
    Hypertens Pregnancy 28:361-8. 2009
    ..The purpose of this study was to determine the predictive value of maternal PAPP-A levels in the identification of women at risk of PIH...
  7. ncbi Study of lipid profile, lipid peroxidation and vitamin E in pregnancy induced hypertension
    Suchanda Sahu
    Department of Biochemistry, Pondicherry Institute of Medical Sciences, Kalapet, Pondicherry 605 014
    Indian J Physiol Pharmacol 53:365-9. 2009
    ..In PIH cases there was a negative correlation of diastolic BP with MDA (P<0.05). Early detection of these parameters is going to aid in better management of PIH cases...
  8. ncbi Hypertensive disorders in pregnancy: a population-based study
    Christine L Roberts
    Centre for Perinatal Health Services Research, University of Sydney, NSW, Australia
    Med J Aust 182:332-5. 2005
    ..To determine population-based rates and outcomes of hypertensive disorders in pregnancy...
  9. ncbi [The relationship between prepregnancy body mass index and the occurrence of pregnancy induced hypertension]
    Ying hui Liu
    Institute of Reproductive and Child Health, Peking University, Beijing 100191, China
    Zhonghua Yu Fang Yi Xue Za Zhi 43:299-304. 2009
    ..To examine the relationship between prepregnancy body mass index (BMI) and the risk of pregnancy-induced hypertension (PIH) in Chinese population...
  10. pmc The accuracy of reporting of the hypertensive disorders of pregnancy in population health data
    Christine L Roberts
    Clinical and Population Perinatal Health Research, The Kolling Institute of Medical Research, University of Sydney, Sydney, Australia
    Hypertens Pregnancy 27:285-97. 2008
    ..To assess the accuracy of hypertensive disorders of pregnancy reporting in birth and hospital discharge data compared with data abstracted from medical records...
  11. ncbi Drugs for treatment of very high blood pressure during pregnancy
    L Duley
    University of Oxford, Nuffield Department of Medicine, Room 5609, Level 5, John Radcliffe Hospital, Headington, Oxford, UK OX3 9DU
    Cochrane Database Syst Rev 3:CD001449. 2006
    ..Very high blood pressure during pregnancy poses a serious threat to women and their babies. Antihypertensive drugs lower blood pressure. Their comparative effects on other substantive outcomes, however, is uncertain...
  12. ncbi Induction of labour versus expectant monitoring for gestational hypertension or mild pre-eclampsia after 36 weeks' gestation (HYPITAT): a multicentre, open-label randomised controlled trial
    Corine M Koopmans
    Department of Obstetrics and Gynaecology, University Medical Centre, Groningen, Netherlands
    Lancet 374:979-88. 2009
    ..We investigated whether induction of labour in women with a singleton pregnancy complicated by gestational hypertension or mild pre-eclampsia reduces severe maternal morbidity...
  13. doi Update on the use of antihypertensive drugs in pregnancy
    Tiina Podymow
    Division of Nephrology, McGill University Health Center, Royal Victoria Hospital, 687 Pine Ave West, Ross 2 38, Montreal, Quebec, Canada H3A 1A1
    Hypertension 51:960-9. 2008
  14. ncbi The association between customised small for gestational age infants and pre-eclampsia or gestational hypertension varies with gestation at delivery
    K M Groom
    Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, School of Population Health Building 730, University of Auckland, Tamaki Campus, Auckland, New Zealand
    BJOG 114:478-84. 2007
    ....
  15. ncbi Supplemental calcium and risk reduction of hypertension, pregnancy-induced hypertension, and preeclampsia: an evidence-based review by the US Food and Drug Administration
    Paula R Trumbo
    Division of Nutrition Programs and Labeling, US Food and Drug Administration, HFS 830, 5100 Paint Branch Parkway, College Park, MD 20740, USA
    Nutr Rev 65:78-87. 2007
    ....
  16. ncbi Thrombomodulin, von Willebrand factor and E-selectin as plasma markers of endothelial damage/dysfunction and activation in pregnancy induced hypertension
    Sunil K Nadar
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Dudley Road, Birmingham B18 7QH, UK
    Thromb Res 113:123-8. 2004
    ....
  17. ncbi Relationship between increased blood lead and pregnancy hypertension in women without occupational lead exposure in Tehran, Iran
    Mohsen Vigeh
    Department of Public Health, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Arch Environ Health 59:70-5. 2004
    ..Results of this study indicated that low-level lead exposure may be a risk factor for pregnancy hypertension...
  18. pmc Induction of labour versus expectant monitoring in women with pregnancy induced hypertension or mild preeclampsia at term: the HYPITAT trial
    Corine M Koopmans
    Department of Obstetrics and Gynaecology, University Medical Centre Groningen, The Netherlands
    BMC Pregnancy Childbirth 7:14. 2007
    Hypertensive disorders, i.e. pregnancy induced hypertension and preeclampsia, complicate 10 to 15% of all pregnancies at term and are a major cause of maternal and perinatal morbidity and mortality. The only causal treatment is delivery...
  19. ncbi Plasma markers of angiogenesis in pregnancy induced hypertension
    Sunil K Nadar
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    Thromb Haemost 94:1071-6. 2005
    ..These abnormalities may have implications for the pathogenesis of PIH and preeclampsia...
  20. ncbi Population-based analysis of hypertensive disorders in pregnancy
    Jack Lawler
    Department of Gynecology Obstetrics, The State University of New York, Buffalo, New York 14222, USA
    Hypertens Pregnancy 26:67-76. 2007
    ..To determine the population-based incidence of hypertensive diseases in pregnancy in Western New York...
  21. ncbi A randomised comparison of hydralazine and mini-bolus diazoxide for hypertensive emergencies in pregnancy: the PIVOT trial
    Annemarie Hennessy
    Hypertensive Disorders of Pregnancy Unit, Royal Prince Alfred Hospital, Sydney, NSW, Australia
    Aust N Z J Obstet Gynaecol 47:279-85. 2007
    ..Rapid control of severe hypertension is necessary to reduce maternal morbidity, for example, stroke and placental abruption. This study was designed to compare the efficacy of mini-bolus diazoxide with intravenous (i.v.) hydralazine...
  22. pmc Prepregnancy body mass index, hypertensive disorders of pregnancy, and long-term maternal mortality
    Margaret E Samuels-Kalow
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Am J Obstet Gynecol 197:490.e1-6. 2007
    ..This study examines the relationship between elevated prepregnancy body mass index (BMI), HDP, and postpregnancy mortality...
  23. ncbi Circulating matrix metalloproteinase-9 and tissue inhibitors of metalloproteinases-1 and -2 levels in gestational hypertension
    Muzahir H Tayebjee
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH, UK
    Am J Hypertens 18:325-9. 2005
    ....
  24. ncbi [The value of a urine protein-to-creatinine ratio assessment in a single voided urine specimen in prediction of 24-hour proteinuria in pregnancy induced hypertension]
    Tomasz Skweres
    Oddział Połozniczo Ginekologiczny Szpitala Miejskiego w Gdyni
    Ginekol Pol 77:415-21. 2006
    ..However, 24-hour urine collection is time consuming, cumbersome and often inaccurate especially during pregnancy. Pregnant women find it very inconvenient and difficult...
  25. ncbi Quality of population health data reporting by mode of delivery
    Christine Roberts
    Birth 34:274-5; author reply 275-6. 2007
  26. ncbi Maternal mortality due to eclamptic and non-eclamptic hypertensive disorders: a challenge
    S Chhabra
    Department of Obstetrics and Gynaecology, Mahatma Gandhi Institute of Medical Sciences, Wardha, Maharashtra, India
    J Obstet Gynaecol 27:25-9. 2007
    ..Evidence-based critical care is essential as even seemingly milder forms of pregnancy induced hypertension can lead to mortality.
  27. ncbi Maternal deaths due to hypertensive disorders in pregnancy
    J Moodley
    Department of Obstetrics and Gynaecology, University of KwaZulu Natal, Durban, South Africa
    Best Pract Res Clin Obstet Gynaecol 22:559-67. 2008
    ....
  28. ncbi Structural changes in umbilical vessels in pregnancy induced hypertension
    A Koech
    Department of Human Anatomy, University of Nairobi, Nairobi, Kenya
    Placenta 29:210-4. 2008
    b>Pregnancy Induced Hypertension (PIH) is associated with placental morphological changes, alterations in the blood flow patterns in the umbilical vessels and adverse fetal and maternal outcome...
  29. pmc Methods for dealing with discrepant records in linked population health datasets: a cross-sectional study
    Christine L Roberts
    The Kolling Institute of Medical Research, St Leonards 2065, Australia
    BMC Health Serv Res 7:12. 2007
    ..However, this raises the possibility of discrepant case reports from different datasets...
  30. ncbi Impaired placental neovascularization in mice with pregnancy-associated hypertension
    Mitsuko Furuya
    Department of Molecular Pathology, Chiba University Graduate School of Medicine, Chiba, Japan
    Lab Invest 88:416-29. 2008
    ..Collective data suggest that the impairments of fetoplacental neovascularization and uteroplacental remodeling contribute to the development of complications in PAH...
  31. ncbi [Relationships between polymorphisms of angiotensin-converting enzyme and methylenetetrahydrofolate reductase genes and genetic susceptibility to pregnancy induced hypertension]
    Hai Yan Wang
    Department of Obstetrics and Gynecology, Huizhou Hospital, Huizhou, 516002, Guangdong Province, China
    Zhonghua Fu Chan Ke Za Zhi 39:369-72. 2004
    To study the relationships between polymorphisms of angiotensin-converting enzyme (ACE) gene and methylenetetrahydrofolate reductase (MTHFR) gene and pregnancy induced hypertension (PIH).
  32. ncbi Maternal and perinatal outcome in pregnancies complicated with hypertensive disorder of pregnancy: a seven year experience of a tertiary care center
    Gulseren Yucesoy
    Department of Obstetrics and Gynecology, School of Medicine, University of Kocaeli, Kocaeli, Turkey
    Arch Gynecol Obstet 273:43-9. 2005
    ..The aim of the study was to determine the risk factors, prevalance, epidemiological parameters and maternal-perinatal outcome in pregnant women with hypertensive disorder...
  33. ncbi Accuracy of serum uric acid in predicting complications of pre-eclampsia: a systematic review
    S Thangaratinam
    Academic Unit of Obstetrics and Gynaecology, Maternity Block, University Hospital of North Staffordshire, Stoke on Trent, UK
    BJOG 113:369-78. 2006
    ..Pre-eclampsia is one of the largest causes of maternal and fetal mortality and morbidity. Hyperuricemia is often associated with pre-eclampsia...
  34. ncbi Microscopic hematuria in pregnancy: relevance to pregnancy outcome
    Mark A Brown
    Department of Renal Medicine, St George Hospital and University of NSW, Kogarah, NSW, Australia
    Am J Kidney Dis 45:667-73. 2005
    ..We sought to determine the prevalence and clinical significance of microscopic hematuria during pregnancy...
  35. ncbi [Obstructive Sleep Apnea Syndrom during pregnancy: prevalence of main symptoms and relationship with Pregnancy Induced-Hypertension and Intra-Uterine Growth Retardation]
    D Calaora-Tournadre
    Service de Gynecologie Obstetrique, CHU La Miletrie, BP 577, 86021 Poitiers Cedex, France
    Rev Med Interne 27:291-5. 2006
    ..To investigate the frequency of main symptoms of Obstructive Sleep Apnea Syndrom (OSAS) and their relationship with Pregnancy Induced-Hypertension (PIH) as well as Intrauterine Growth Retardation (IGR) as suggested by recent studies...
  36. ncbi Angiotensinogen gene variants and small-for-gestational-age infants
    C Tower
    Division of Clinical Chemistry, Institute of Genetics, School of Molecular Medical Sciences, University Hospital, Nottingham, UK
    BJOG 113:335-9. 2006
    ..04), suggesting that AGT may play a role in the complex relationship between body mass and blood pressure in healthy pregnant women...
  37. ncbi Maternal hypertension and neonatal outcome among small for gestational age infants
    Alexandra Bageris
    Obstet Gynecol 106:1416; author reply 1416-7. 2005
  38. ncbi History of fetal growth restriction is more strongly associated with severe rather than milder pregnancy-induced hypertension
    Svein Rasmussen
    Medical Birth Registry of Norway, Locus of Registry Based Epidemiology, Institute of Community Medicine and Primary Health Care, University of Bergen and Norwegian Institute of Public Health, Bergen, Norway
    Hypertension 51:1231-8. 2008
    ..Future genetic study is needed to confirm whether the association is caused by delayed genetic expression of endothelial dysfunction and whether the clinical subgroups of PIH have different genetic backgrounds...
  39. ncbi Cardiac complications relating to pregnancy and recurrence of disease in the offspring of women with atrioventricular septal defects
    Willem Drenthen
    Department of Cardiology, University Medical Centre Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Eur Heart J 26:2581-7. 2005
    ..To investigate the magnitude and determinants of risk during pregnancy in female patients with balanced AVSD...
  40. ncbi Bilateral notching of uterine arteries at 12--14 weeks of gestation for prediction of hypertensive disorders of pregnancy
    Merja Vainio
    Department of Obstetrics and Gynecology, Hyvinkaa Hospital, Hyvinkaa, Finland
    Acta Obstet Gynecol Scand 84:1062-7. 2005
    ..To assess the value of transvaginal uterine artery Doppler ultrasound at 12--14 weeks of gestation in predicting hypertensive disorders of pregnancy in high-risk women...
  41. ncbi [Hypertension, pre-eclampsia and eclampsia--monitoring and outcome of pregnancy]
    Ilija Grujić
    Zdravstveni centar Veljko Vlahovic, Vrbas
    Med Pregl 59:556-9. 2006
    ..Pregnancy-induced hypertension is one of the major causes of maternal and fetal/neonatal morbidity and mortality...
  42. ncbi Placental imbalance of Th1- and Th2-type cytokines in preeclampsia
    Minyue Dong
    Women s Hospital, School of Medicine, Zhejiang University, 2 Xueshi Road, Hangzhou, Zhejiang 310006, China
    Acta Obstet Gynecol Scand 84:788-93. 2005
    ....
  43. ncbi Maternal urine albumin excretion and pregnancy outcome
    Nora Franceschini
    Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, NC 27599 7155, USA
    Am J Kidney Dis 45:1010-8. 2005
    ..The relationship between increased urine albumin excretion (albuminuria), a marker of endothelial dysfunction, and preterm birth has not been fully evaluated...
  44. ncbi Association of angiotensin-converting enzyme gene polymorphism with pregnancy-induced hypertension
    Rajpal Kaur
    Department of Obstetrics and Gynaecology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Acta Obstet Gynecol Scand 84:929-33. 2005
    ..To investigate the potential association of angiotensin-converting enzyme (ACE) gene polymorphism and serum ACE activity with pregnancy-induced hypertension (PIH)...
  45. ncbi Shared constitutional risks for maternal vascular-related pregnancy complications and future cardiovascular disease
    Anne L Berends
    Division of Obstetrics and Prenatal Medicine, Department of Obstetrics and Gynecology, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Hypertension 51:1034-41. 2008
    ..These findings suggest shared constitutional risks for vascular-related pregnancy complications and future cardiovascular disease...
  46. ncbi Mean platelet and red blood cell volume measurements to estimate the severity of hypertension in pregnancy
    Juan Piazze
    J Perinat Med 34:246-7. 2006
  47. ncbi [Changes of T-helper 1 and T-helper 2 ratio in peripheral blood and decidua in hypertensive disorder complicating pregnancy]
    Ying pu Lü
    Department of Obstetrics and Gynecology, Second Hospital, Hebei Medical University, Shijiazhuang 050000, China
    Zhonghua Fu Chan Ke Za Zhi 41:103-6. 2006
    ....
  48. pmc Polymorphism in maternal LRP8 gene is associated with fetal growth
    Lin Wang
    Program for Population Genetics, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Hum Genet 78:770-7. 2006
    ..05). In conclusion, results from the two independent samples of black women provide consistent evidence that SNP rs2297660 in LRP8 is associated with fetal growth...
  49. ncbi [Treatment effectiveness of hypertension during pregnancy]
    Mauro Henrique de Lima Ferrão
    Departamento de Ciencias Biologicas, Universidade Federal do Triangulo Mineiro, Avenida Frei Paulino no 30, Bairro Abadia, 38025 180 Uberaba, Minas Gerais
    Rev Assoc Med Bras 52:390-4. 2006
    ..To compare the maternal-fetal clinical intercurrences and the effectiveness of treatment in the different clinical forms of hypertensive syndromes during pregnancy (HSP)...
  50. pmc High-altitude ancestry protects against hypoxia-associated reductions in fetal growth
    Colleen Glyde Julian
    Colleen Glyde Julian, University of Colorado Altitude Research Center, University of Colorado at Denver and Health Sciences Center, Campus Box B123, 4200 East Ninth Avenue, Suite 301 BRB, Denver, Colorado 80262, USA
    Arch Dis Child Fetal Neonatal Ed 92:F372-7. 2007
    ....
  51. ncbi A meta-analysis of pregnancy outcomes in women with polycystic ovary syndrome
    C M Boomsma
    Department of Reproductive Medicine and Gynaecology, University Medical Center Utrecht, Utrecht, The Netherlands
    Hum Reprod Update 12:673-83. 2006
    ..07; 95% CI: 1.03-9.21), unrelated to multiple births. In conclusion, women with PCOS are at increased risk of pregnancy and neonatal complications. Pre-pregnancy, antenatal and intrapartum care should be aimed at reducing these risks...
  52. ncbi [Hypertension treatment during pregnancy]
    V Homuth
    Franz Volhard Klinik, Abt Nephrologie Hypertensiologie Helios Klinikum, Charite, Berlin
    MMW Fortschr Med 149:45-8. 2007
  53. ncbi [Morbidity regularity of severe complications of hypertensive disorder complicating pregnancy in clinics]
    Shu mei Wan
    Department of Obstetrics and Gynecology, Guangzhou General Hospital of Guangzhou Military Area Command, Guangzhou 510010, China
    Zhonghua Fu Chan Ke Za Zhi 42:510-4. 2007
    ..To analyse incidence of the severe complications of hypertensive disorder complicating pregnancy and the influence on the outcome of pregnancy...
  54. ncbi Hypertensive disorders of pregnancy and the small for gestational age neonate: not a simple relationship
    Sorina Grisaru-Granovsky
    Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, Jerusalem, Israel
    Am J Obstet Gynecol 196:335.e1-5. 2007
    ..The purpose of this study was to ascertain whether hypertensive disorders of pregnancy and SGA correlate with severity of hypertension, suggestive of common pathophysiological pathways...
  55. ncbi Reduced maternal corticosteroid-binding globulin and cortisol levels in pre-eclampsia and gamete recipient pregnancies
    Jui T Ho
    Hanson Institute, University of Adelaide, and Endocrine and Metabolic Unit of the Royal Adelaide Hospital, Adelaide, South Australia, Australia
    Clin Endocrinol (Oxf) 66:869-77. 2007
    ..To measure and contrast maternal cortisol and corticosteroid-binding globulin (CBG) levels in pregnancies with normal outcomes, pre-eclampsia, intrauterine growth restriction (IUGR) and in gamete recipients...
  56. ncbi Application of the magnitude-squared coherence function between uterine and umbilical flow velocity waveforms for predicting placental dysfunction: a preliminary study
    Pieter C Struijk
    Department of Obstetrics and Gynecology, Erasmus MC, Division Obstetrics and Prenatal Medicine, Rotterdam, The Netherlands
    Ultrasound Med Biol 33:1057-63. 2007
    ..Binary logistic prediction models are created for preeclampsia, pregnancy induced hypertension and intrauterine growth restriction in a study group of 284 unselected midtrimester pregnancies...
  57. pmc Gestational hypertension in pregnancies supported by infertility treatments: role of infertility, treatments, and multiple gestations
    Sonia Hernandez-Diaz
    Slone Epidemiology Center at Boston University, Boston, Massachusetts 02215, USA
    Fertil Steril 88:438-45. 2007
    ..To investigate the association between infertility treatments and gestational hypertension and preeclampsia...
  58. ncbi Neonatal outcomes in pregnancies with preeclampsia or gestational hypertension and in normotensive pregnancies that delivered at 35, 36, or 37 weeks of gestation
    Mounira Habli
    Department of Obstetrics and Gynecology, University of Cincinnati, Cincinnati, OH, USA
    Am J Obstet Gynecol 197:406.e1-7. 2007
    ..The purpose of this study was to compare neonatal outcomes of pregnancies with preeclampsia or gestational hypertension with those of normotensive pregnancies that delivered at 35, 36, or 37 weeks of gestation separately...
  59. ncbi Association between birth weight and first-trimester free beta-human chorionic gonadotropin and pregnancy-associated plasma protein A
    Silvana Canini
    Laboratorio di Analisi, Universita di Genova, Genova, Italy
    Fertil Steril 89:174-8. 2008
    ..To assess the relationship between first-trimester maternal serum PAPP-A and free beta-hCG and birth weight...
  60. ncbi Biomarker for hypertension-preeclampsia: are we close yet?
    Baha M Sibai
    Am J Obstet Gynecol 197:1-2. 2007
  61. ncbi Relationship between thrombophilic disorders and type of severe early-onset hypertensive disorder of pregnancy
    Wessel Ganzevoort
    Department of Obstetrics and Gynaecology, Academic Medical Centre, Amsterdam, The Netherlands
    Hypertens Pregnancy 26:433-45. 2007
    ....
  62. ncbi Effect of homocysteine concentration in early pregnancy on gestational hypertensive disorders and other pregnancy outcomes
    Linda Dodds
    Departments of Obstetrics and Gynaecology and Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada
    Clin Chem 54:326-34. 2008
    ..This study was undertaken to determine whether increased tHcy measured in early pregnancy is associated with pregnancy loss, gestational hypertension (GH), preeclampsia, or small for gestational age (SGA) infants...
  63. ncbi Smoking in moderate/severe preeclampsia worsens pregnancy outcome, but smoking cessation limits the damage
    F Broughton Pipkin
    Department of Obstetrics and Gynaecology, Maternity Unit, City Hospital, Nottingham NG5 1PB, United Kingdom
    Hypertension 51:1042-6. 2008
    ....
  64. ncbi Prediction of maternal complications and adverse infant outcome at admission for temporizing management of early-onset severe hypertensive disorders of pregnancy
    Wessel Ganzevoort
    Department of Obstetrics and Gynecology, Academic Medical Centre, Amsterdam, The Netherlands
    Am J Obstet Gynecol 195:495-503. 2006
    ..We explored the association between clinical parameters at admission and the subsequent development of major maternal complications or adverse infant outcome in women with hypertensive complications of pregnancy remote from term...
  65. ncbi Total vascular resistance and left ventricular morphology as screening tools for complications in pregnancy
    Barbara Vasapollo
    Department of Obstetric and Gynecology, Tor Vergata University, Rome, Italy
    Hypertension 51:1020-6. 2008
    ..05). Echocardiography might identify at 24 weeks' gestation patients who subsequently develop maternal and fetal complications through the assessment of maternal hemodynamics and left ventricular geometry...
  66. ncbi Prediction of pre-eclampsia by uterine artery Doppler imaging: relationship to gestational age at delivery and small-for-gestational age
    C K H Yu
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital Medical School, London, UK
    Ultrasound Obstet Gynecol 31:310-3. 2008
    ..To determine the relationship between pre-eclampsia, small-for-gestational age (SGA) and gestational age at delivery, and the effect of this relationship on the prediction of pre-eclampsia by uterine artery Doppler imaging...
  67. ncbi Low-molecular-weight heparin improves the performance of uterine artery Doppler velocimetry to predict preeclampsia and small-for-gestational age infant in women with gestational hypertension
    Michela Torricelli
    Obstretrics and Gynecology, Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy
    Ultrasound Med Biol 32:1431-5. 2006
    ..91) and SGA (LR + 4.69) compared with the first Doppler examination (LR + 1.97 and 2.22, respectively). Thus, LMWH improved the performance of uterine artery RI to predict preeclampsia and SGA in women with gestational hypertension...
  68. ncbi High maternal and fetal plasma urocortin levels in pregnancies complicated by hypertension
    Pasquale Florio
    Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy
    J Hypertens 24:1831-40. 2006
    ....
  69. ncbi Phenotypic characteristics shared by preeclamptic patients and an animal model of the syndrome: report of a pilot study
    Arnold B Alper
    Department of Medicine, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Am J Hypertens 19:947-50. 2006
    ..We addressed the question of whether there was a group of such patients with the characteristics of our rat model. These include hypertension, proteinuria, IUGR, and either normal or only mildly abnormal GFR...
  70. ncbi Hypertension in pregnancy: hospital based study
    J Prakash
    Department of Nephrology Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
    J Assoc Physicians India 54:273-8. 2006
    ..38% of all pregnancies in our study. Preeclampsia-eclampsia and its variants remain the major cause of hypertension in pregnant women. Hypertension during pregnancy is responsible for high fetal mortality and low birth weight...
  71. ncbi Maternal cardiac output between 11 and 13 weeks of gestation in the prediction of preeclampsia and small for gestational age
    Catalina De Paco
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, United Kingdom
    Obstet Gynecol 111:292-300. 2008
    ..To investigate maternal cardiac output in the first trimester as a predictor of preeclampsia and delivery of small for gestational age (SGA) infants...
  72. ncbi Reproductive issues for adults with autosomal dominant polycystic kidney disease
    Neeta Vora
    Department of Pediatrics, Tufts New England Medical Center and Floating Hospital for Children, Boston, MA 02111, USA
    Am J Kidney Dis 51:307-18. 2008
    ..We review in detail these topics to familiarize physicians taking care of patients with ADPKD with the reproductive issues that confront affected individuals...
  73. ncbi Non-proteinuric pre-eclampsia: a novel risk indicator in women with gestational hypertension
    Caroline S E Homer
    Centre for Midwifery, Child and Family Health, Faculty of Nursing, Midwifery and Health, University of Technology, Sydney, Australia
    J Hypertens 26:295-302. 2008
    ..To determine whether outcomes differed for women with pre-eclampsia according to the presence of proteinuria and whether non-proteinuric pre-eclampsia is similar to gestational hypertension...
  74. pmc Evidence of endothelial dysfunction in preeclampsia and risk of adverse pregnancy outcome
    Robert W Powers
    Magee Womens Research Institute, Pittsburgh, Pennsylvania 15213, USA
    Reprod Sci 15:374-81. 2008
    ..5-13.1) in women with preeclampsia, hyperuricemia, and elevated cFN compared with normotensive women. Elevated cFN is prevalent among women with preeclampsia and identifies women at increased risk of preterm delivery and SGA...
  75. pmc Effect of Body Mass Index on pregnancy outcomes in nulliparous women delivering singleton babies
    Sohinee Bhattacharya
    Dugald Baird Centre for Research on Women s Health, Aberdeen Maternity Hospital, Aberdeen, UK
    BMC Public Health 7:168. 2007
    ..In a population based cohort study, using routinely collected data, this paper examines the effect of increasing Body Mass Index (BMI) on pregnancy outcomes in nulliparous women delivering singleton babies...
  76. ncbi Maternal hypertension as a risk factor for low birth weight infants: comparison of Haitian and African-American women
    Christine D Odell
    Department of Family Medicine, Boston Medical Center Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Matern Child Health J 10:39-46. 2006
    ..The rate of low birth weight (LBW) of Black women is more than twice that of White women. This study explores if the rate of LBW differs between Haitian and African-American women with chronic hypertension...
  77. ncbi Soluble endoglin and other circulating antiangiogenic factors in preeclampsia
    Richard J Levine
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Department of Health and Human Services, Bethesda, MD 20892, USA
    N Engl J Med 355:992-1005. 2006
    ..Since soluble endoglin, another antiangiogenic protein, acts together with sFlt1 to induce a severe preeclampsia-like syndrome in pregnant rats, we examined whether it is associated with preeclampsia in women...
  78. ncbi Pregnancy and severe chronic hypertension: maternal outcome
    Paulino Vigil-De Gracia
    Obstetric Intensive Unit, Department of Gynecology and Obstetrics, Complejo, Hospitalario Arnulfo Arias Madrid, Caja de Seguro Social, Panama, Panama
    Hypertens Pregnancy 23:285-93. 2004
    ..To determine the maternal outcome associated with severe chronic hypertension during the second half of pregnancy...
  79. ncbi Release of inositol phosphoglycan P-type by the human placenta following insulin stimulus: a multiple comparison between preeclampsia, intrauterine growth restriction, and gestational hypertension
    Marco Scioscia
    Department of Immunology and Molecular Pathology, Molecular Medicine Unit, Royal Free and University College London Medical School, London, UK
    J Matern Fetal Neonatal Med 21:581-5. 2008
    ..This study was undertaken to assess the release of this mediator in intrauterine growth restriction (IUGR) and hypertensive disorders other than preeclampsia...
  80. ncbi Hypertensive disorders in Japanese women with gestational glucose intolerance
    Kei Miyakoshi
    Department of Obstetrics and Gynecology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Diabetes Res Clin Pract 64:201-5. 2004
    ..2% or 4.1%, respectively, compared to those with normal glucose tolerance). Japanese women with gestational glucose intolerance therefore have an increased risk of developing GH...
  81. ncbi A comparison of walking versus stretching exercises to reduce the incidence of preeclampsia: a randomized clinical trial
    SeonAe Yeo
    School of Nursing, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7460, USA
    Hypertens Pregnancy 27:113-30. 2008
    ..To compare a walking exercise to a stretching exercise during pregnancy in high-risk women who were sedentary and had previously experienced preeclampsia...
  82. ncbi [Obstetrical complications of morbid obesity]
    E Grossetti
    Service de gynécologie obstétrique et médecine de la reproduction
    J Gynecol Obstet Biol Reprod (Paris) 33:739-44. 2004
    ..To determine whether morbidly obese women have an increased risk of pregnancy complications and adverse perinatal outcome...
  83. ncbi Hypertension during pregnancy in South Australia, part 1: pregnancy outcomes
    Adrian R Heard
    Epidemiology Branch, Department of Human Services, University of Adelaide, Lyell McEwin Health Service, South Australia, Australia
    Aust N Z J Obstet Gynaecol 44:404-9. 2004
    ..There have been conflicting reports about pregnancy outcome in the hypertensive disorders of pregnancy. The present study was undertaken to examine outcomes using a population database...
  84. ncbi Factor VIII levels and the risk of pre-eclampsia, HELLP syndrome, pregnancy related hypertension and severe intrauterine growth retardation
    C P J Witsenburg
    Department of Obstetrics, Leiden University Medical Center, K6 27, PO Box 9600 2300 RC Leiden, The Netherlands
    Thromb Res 115:387-92. 2005
    ....
  85. doi Hypertensive disorders of pregnancy: a UK-based perspective
    Manju Chandiramani
    King s College London, Division of Reproduction and Endocrinology, London, UK
    Curr Opin Obstet Gynecol 20:96-101. 2008
  86. ncbi Maternal complications and perinatal outcomes associated with gestational hypertension and severe preeclampsia in Taiwanese women
    Ching Ming Liu
    Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan
    J Formos Med Assoc 107:129-38. 2008
    ..The objective of this study was to compare the effects of disease severity on maternal complications and pregnancy outcome between women with severe preeclampsia and women with gestational hypertension...
  87. ncbi Erythrocyte omega-3, omega-6 and trans fatty acids in relation to risk of preeclampsia among women delivering at Harare Maternity Hospital, Zimbabwe
    K Mahomed
    Department of Obstetrics and Gynecology, University of Zimbabwe, School of Medicine, Harare, Zimbabwe
    Physiol Res 56:37-50. 2007
    ..Given the limited inter-person variation in omega-3 fatty acids among Zimbabwean women, our sample size may be too small to adequately assess the relation in this population...
  88. ncbi [Hypertension in pregnancy]
    R Cifkova
    Pracoviste preventivní kardiologie IKEM, Praha
    Vnitr Lek 52:263-70. 2006
    ..Treatment with diuretics is not substantiated, unless oliguria is present. I.v. magnesium sulphate is recommended for prevention of eclampsia and spasm treatment...
  89. ncbi Circulating endothelial cell adhesion molecules as diagnostic markers for the early identification of pregnant women at risk for development of preeclampsia
    T Krauss
    Department of Obstetrics and Gynecology, University of Gottingen, Germany
    Am J Obstet Gynecol 177:443-9. 1997
    ....
  90. ncbi Intrapartum late deceleration develops more frequently in pre-eclamptic women with severe proteinuria
    Seishi Furukawa
    Department of Obstetrics and Gynecology, Miyazaki Medical College, University of Miyazaki, Miyazaki, Japan
    J Obstet Gynaecol Res 32:68-73. 2006
    ..Our purpose was to investigate the effect of proteinuria associated with pre-eclampsia on intrapartum fetal heart rate patterns...
  91. ncbi Antibodies against oxidized low density lipoproteins in pregnant women
    L Fialova
    First Institute of Medical Chemistry and Biochemistry, Charles University, Prague, Czech Republic
    Physiol Res 51:355-61. 2002
    ..Weak cross-reactivity between oLAb and anticardiolipin antibodies may exist but there is a possibility that there are two different populations of antibodies reacting with various antigens...
  92. ncbi MOS HIP: McMaster outcome study of hypertension in pregnancy
    J G Ray
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Early Hum Dev 64:129-43. 2001
    ..The risk of developing these outcomes among women with either preeclampsia or chronic hypertension, relative to those with gestational hypertension, is not known...
  93. ncbi [Relations of pre-pregnant weight and weight gain during pregnancy with pregnancy-induced hypertension and birth weight]
    Yu Zhu Yin
    Department of Obstetrics and Gynecology, Third Affiliated Hospital, Sun Yat Sen University, Guangzhou 510630, China
    Di Yi Jun Yi Da Xue Xue Bao 25:226-8. 2005
    ..To determine the influence of pre-pregnant body mass index (BMI) and weight gain during pregnancy on the occurrence of pregnancy-induced hypertension (PIH) and birth weight...
  94. ncbi [Clinical analysis of cardiac reserve function and outcome of preeclampsia.]
    Yong Shao
    Department of Obstetrics and Gynecology, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China Email
    Zhonghua Fu Chan Ke Za Zhi 44:736-9. 2009
    ..To investigate cardiac reserve function and pregnant results of preeclampsia...
  95. ncbi Association of preeclampsia with high birth weight for age
    X Xiong
    Perinatal Research Centre, the Department of Public Health Science, University of Alberta, Edmonton, Canada
    Am J Obstet Gynecol 183:148-55. 2000
    ..The purpose of this study was to examine the effect of gestational hypertension and preeclampsia on fetal growth...
  96. ncbi Impact of pregnancy-induced hypertension on birthweight by gestational age
    Xu Xiong
    Department of Obstetrics and Gynecology, University of Montreal, Quebec, Canada
    Paediatr Perinat Epidemiol 18:186-91. 2004
    ..In this Chinese population, most babies born to mothers with severe pre-eclampsia or pre-eclampsia and gestational hypertension had similar fetal growth to those born to normotensive mothers...
  97. ncbi Changes of dimeric inhibin B levels in maternal serum throughout healthy gestation and in women with gestational diseases
    F Petraglia
    Department of Gynecology, Obstetrics and Pediatric Sciences, University of Modena, Italy
    J Clin Endocrinol Metab 82:2991-5. 1997
    ..The present study showed that maternal serum inhibin B levels increase in the last trimester of normal pregnancy, with low levels in women with hypertensive disturbances or intrauterine growth retardation...
  98. pmc Prevalence and clinical significance of postpartum endometritis and wound infection
    W Chaim
    Department of Obstetrics and Gynecology, Soroka University Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Infect Dis Obstet Gynecol 8:77-82. 2000
    ....
  99. ncbi Hyperhomocysteinemia, pregnancy complications, and the timing of investigation
    Regine P Steegers-Theunissen
    Department of Obstetrics and Gynecology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Obstet Gynecol 104:336-43. 2004
    ..To assess associations between vitamin-dependent homocysteine metabolism and vascular-related pregnancy complications by considering interval between delivery and postpartum investigation and maternal age...
  100. ncbi Preeclampsia, gestational hypertension and intrauterine growth restriction, related or independent conditions?
    Jose Villar
    United Nations Development Programme United Nations Population Fund World Health Organization World Bank Special Program of Research, Department of Reproductive Health and Research, World Health Organization, Geneva, Switzerland
    Am J Obstet Gynecol 194:921-31. 2006
    ..In this study, we compared determinants and perinatal outcomes associated with these obstetric conditions...
  101. ncbi A randomized comparison of early with conservative use of antihypertensive drugs in the management of pregnancy-induced hypertension
    P F Plouin
    Institut National de la Sante et de la Recherche Medicale, Units 36 and 149, Paris
    Br J Obstet Gynaecol 97:134-41. 1990
    ..However, it may prevent acute hypertension in late pregnancy and associated fetal distress, and thus reduce the number of caesarean sections...

Research Grants62

  1. Complement Activation in Pregnancy and Hypertension
    Jean F Regal; Fiscal Year: 2013
    ....
  2. Vascular Mechanisms in Pregnancy-Induced Hypertension
    Raouf A Khalil; Fiscal Year: 2013
    ....
  3. Hypertension, Kidney and Pregnancy
    Joey P Granger; Fiscal Year: 2013
    ..Based on preliminary data presented in this application, we propose that induction of hemeoxygenase-1 and its catalytic products, carbon monoxide and bilirubin, may provide a novel therapeutic approach for the treatment of PE. ..
  4. Role of endocrine-disrupting chemicals and social stress on perinatal outcomes
    Ami R Zota; Fiscal Year: 2012
    ..Results from this work will improve pregnancy outcomes and inform public health policy, particularly for vulnerable subpopulations, who often encounter elevated exposures to chemical and non-chemical stressors. ..
  5. Comparative safety &effectiveness of antihypertensive medications in pregnancy
    BRIAN THOMAS BATEMAN; Fiscal Year: 2013
    ..This combination of intensive research, mentoring, and formal education will provide the necessary background for me to become a successful, independent researcher in obstetric pharmacoepidemiology. ..
  6. A Prospective Cohort Study of Migraines, Platelet Activation, and Preeclampsia
    Michelle A Williams; Fiscal Year: 2012
    ....
  7. Serine Protease Corin in Pregnancy-induced Hypertension
    Qingyu Wu; Fiscal Year: 2013
    ..In this study, we will try to understand how corin works and if we can develop new corin-based methods to diagnose and treat high blood pressure during pregnancy. 1 ..
  8. Pregnancy complications, future cardiovascular disease risk factors and cardiovas
    NISHA INDRAVADAN PARIKH; Fiscal Year: 2013
    ....
  9. Role of endocrine-disrupting chemicals and social stress on perinatal outcomes
    Ami R Zota; Fiscal Year: 2013
    ..abstract_text> ..
  10. Vasomotor Sympathetic Activity during Early Pregnancy in Humans
    Qi Fu; Fiscal Year: 2010
    ..Results obtained will provide novel insights into how blood pressure is regulated by the sympathetic nervous system during normal pregnancy, particularly during early pregnancy in humans. ..
  11. Placental Insufficiency in Transgenic Mouse Model of Preeclampsia and IUGR
    TERRY KNUD MORGAN; Fiscal Year: 2013
    ..Our results will help us better understand the underlying pathology of these serious human diseases and are the first steps toward future studies investigating molecular mechanisms and potential applications in women. ..
  12. Integrating Environmental Cues at the Maternal-Fetal Vascular Interface
    Emin Maltepe; Fiscal Year: 2013
    ..Importantly, the combination of directed and unbiased approaches designed to dissect the pathways involved may lead to novel pharmacological targets to prevent or treat this intractable disorder. ..
  13. Long-Term Burden of Maternal Cardiovascular Risk Factors and Birth Outcomes
    EMILY WHEELER HARVILLE; Fiscal Year: 2013
    ..This proposal takes advantage of the unique opportunity to use 35 years of longitudinal research, beginning in childhood, in a biracial population. ..
  14. Air Pollution and Pregnancy Outcome in New York City
    David A Savitz; Fiscal Year: 2013
    ..Through these efforts, we will be able to substantially advance our understanding of the hypothesized causal link between air pollution and pregnancy outcome, addressing a question of substantial public health and regulatory importance. ..
  15. Maternal Genetic Variation and Risk of Adverse Pregnancy Outcomes
    Stephanie M Engel; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Preterm birth, small-for-gestational age (SGA) and pregnancy induced hypertension (PIH) are major pregnancy complications that impact the health of the mother and the child, often resulting in ..
  16. Complement Activation and Hypertensive Diseases of Pregnancy
    Anne M Lynch; Fiscal Year: 2012
    ..If our hypothesis is proven there may be therapeutic implications as several complement inhibitors are now available that target various components of the complement system thus modifying the effects of the inflammatory cascade. ..
  17. Bayesian integration of biomarkers and spatial exposure data
    SCOTT MICHAEL BARTELL; Fiscal Year: 2013
    ..These Bayesian models should 1.) improve exposure rankings for epidemiologic analyses and 2.) allow for direct characterization of the effects of spatial uncertainty on the reliability of epidemiologic findings. ..
  18. Sleep Disturbance and risk for adverse pregnancy outcomes
    Phyllis C Zee; Fiscal Year: 2013
    ..The results of this study have the potential to inform and change clinical care to improve pregnancy outcomes. ..
  19. FASEB SRC on Renal Hemodynamics: Integrating with the nephron and beyond
    David M Pollock; Fiscal Year: 2013
    ..in hypertension and renal function;novel mechanisms of angiotensin system function;epigenetics and pregnancy induced hypertension and renal dysfunction;reactive oxygen species;hypoxia and ischemic injury;and renal medullary ..
  20. ARACHIDONATE LIPOXYGENASE ACTIVITIES IN HUMAN PREGNANCY
    Murray Mitchell; Fiscal Year: 1992
    ..Hence, more effective approaches to the management of such pregnancies may be developed...
  21. Pregnancy Outcomes in Polycystic Ovary Syndrome
    Joan Lo; Fiscal Year: 2009
    ....
  22. METABOLISM OF DIGITALIS LIKE FACTORS
    Roland Valdes; Fiscal Year: 2002
    ..elevated levels of endogenous DLIF in serum from patients with essential hypertension (EH), pregnancy induced hypertension (PIH), and during cardiac dysfunction...
  23. Magnesium's Antihypertensive Effects in Preeclampsia
    CYNTHIA STANDLEY; Fiscal Year: 2003
    ..Data derived from these experiments will elucidate the anti-hypertensive effects of magnesium, its mode of action and the roles of NO and magnesium in preeclampsia and pregnancy-induced hypertension. ..
  24. PATHOGENESIS OF THROMBOCYTOPENIAS OF NEONATES
    Robert Christensen; Fiscal Year: 2002
    ..This approach is essential to improve the care of the large number of NICU patients affected with these two common varieties of thrombocytopenia. ..
  25. ABNORMAL SODIUM HOMEOSTASIS IN HYPERTENSIVE PREGNANCY
    Steven Graves; Fiscal Year: 1992
    ....
  26. CARDIAC RESPONSE TO ESTROGEN & HYPERTENSION
    MARK MORTON; Fiscal Year: 1991
    ..We will use morphometry to determine myocardial cell size, subcellular constituents, and interstitial fibrosis in order to detect the presence of hypertrophy and whether the response is physiologic or pathologic...
  27. REGULATION OF PLACENTAL VASCULAR REACTIVITY IN PIH
    Leslie Myatt; Fiscal Year: 1991
    ....
  28. A Pilot Study of Novel Candidate Genes for Preeclampsia
    Sue Ingles; Fiscal Year: 2005
    ..While the likely severity of such bias has been debated in the epidemiologic literature, there have been no studies to assess the extent of this problem in Hispanics, one of the populations that is most likely to be affected. ..
  29. INSULIN RESISTANCE AND CALCIUM METABOLISM IN PREGNANCY
    James Sowers; Fiscal Year: 1993
    ....
  30. CALCIUM INTAKE, METABOLISM & GESTATIONAL BLOOD PRESSURE
    Cynthia Morris; Fiscal Year: 1990
    ..These observations should provide data to construct testable hypotheses for further research into the putative mechanisms of calcium's influence in pregnancy-induced hypertension...
  31. BIRTHWEIGHT AND GESTATIONAL AGE AND CHRONIC DISEASE RISK
    Tim Byers; Fiscal Year: 2000
    ..abstract_text> ..
  32. HUMORAL CONTROL OF THE HUMAN PLACENTAL CIRCULATION
    Leslie Myatt; Fiscal Year: 1990
    ..III. The vasoactive effects of naturally occurring epoxy- eicosatrienoic acid metabolites of arachidonic acid in the perfused placenta...
  33. NEUROCHEMICAL SPINAL CIRCUITRY AND UTERINE INNERVATION
    RAYMOND PAPKA; Fiscal Year: 2000
    ....
  34. ANGIOTENSIN PROSTANOIDS & HEMODYNAMICS DURING PREGNANCY
    Gail Brown; Fiscal Year: 1991
    ..It is anticipated that these studies will ultimately help define the pathophysiology of pregnancy induced hypertension.
  35. ETIOLOGIC FACTORS FOR PREGNANCY-INDUCED HYPERTENSION
    Audrey Saftlas; Fiscal Year: 1999
    ....
  36. VASCULAR THROMBOXANE RECEPTORS IN HUMAN PLACENTA
    BARRY WILKES; Fiscal Year: 1992
    ..These studies may ultimately lead to a pharmacological rationale for treating disorders of the fetoplacental circulation...
  37. Renal and Cardiovascular Dysfunction in Hypertension and Pregnancy
    Jeffrey Gilbert; Fiscal Year: 2007
    ..The increased understanding of the function of sFlt-1 in PIH may lead to novel therapies for the treatment of PIH. [unreadable] [unreadable] [unreadable] [unreadable]..
  38. BONE LEAD STORES AND PREGNANCY INDUCED HYPERTENSION
    John Bogden; Fiscal Year: 1999
    ..Thus, these studies may explain the variability of the results of other investigations that have assessed the independent effects of calcium and lead on blood pressure during pregnancy. ..
  39. ENDOGENOUS CO AND O2 TRANSFER IN PREGNANCY HYPERTENSION
    STEPHEN ENTMAN; Fiscal Year: 1990
    b>Pregnancy induced hypertension (PIH) complicates 5% of pregnancies and is associated with perinatal and maternal morbidity and mortality. Fetal hypoxia is common but only sporadically responds to reduced vasospasm...
  40. DOPPLER SCREENING FOR PREGNANCY-INDUCED HYPERTENSION
    Laurence Needleman; Fiscal Year: 1992
    b>Pregnancy induced hypertension (PIH) is a major disease of the obstetrical population and is associated with significant maternal and infant morbidity and mortality...
  41. Cardiovascular Disease Following Hypertensive Pregnancy
    Myles Wolf; Fiscal Year: 2007
    ..They believe the results will provide critical insight into mechanisms of CVD in women and potentially suggest means to alter their CVD risk. [unreadable] [unreadable]..
  42. RANDOMIZED TRIAL OF ZINC SUPPLEMENTATION IN PREGNANCY
    Robert Goldenberg; Fiscal Year: 1993
    ..Risk factors known to influence fetal growth, including pregnancy induced hypertension, diabetes, smoking history, alcohol and drug consumption, maternal weight, weight gain, and height, ..
  43. Cardiorenal Mechanisms of Pregnancy induced Hypertension
    Derrick Chandler; Fiscal Year: 2006
    ..abstract_text> ..
  44. Early Life and genetic effects on obesity and diabetes
    Kelly Hunt; Fiscal Year: 2006
    ..abstract_text> ..
  45. Mechanisms of Pregnancy Induced Hypertension
    Babbette LaMarca; Fiscal Year: 2007
    The objective of this research is to define the mechanisms mediating pregnancy induced hypertension. The central hypothesis to be tested in this proposal is that a reduction in uteroplacental perfusion pressure causes hypertension by ..
  46. ANTIPHOSPHOLIPID ANTIBODY AND HYPERTENSION IN PREGNANCY
    Neal Rote; Fiscal Year: 1991
    ..In addition, we will develop a rabbit model for antiphospholipid antibody-induced PIH...
  47. ANDROGENS, LIPIDS, INSULIN AND HYPERTENSIVE PREGNANCIES
    Ravi Thadhani; Fiscal Year: 2005
    ..abstract_text> ..
  48. STRUCTURE/FUNCTION OF EPOXIDE HYDROLASE
    David Christianson; Fiscal Year: 2005
    ..abstract_text> ..
  49. Mechanisms of uterine vascular adaptation in pregnancy
    Natalia Gokina; Fiscal Year: 2006
    ..abstract_text> ..
  50. VASCULAR REACTIVITY IN NORMAL & HYPERTENSIVE PREGNANCIES
    RONALD MAGNESS; Fiscal Year: 1992
    ....
  51. SUPERANTIGEN INVOLVEMENT IN PREECLAMPSIA
    JULIE DELOIA; Fiscal Year: 2002
    ..Studies will be initiated to define the source of the superantigen by challenging normal T-cells with plasma and syncytiotrophoblast microvillous membrane preparations from preeclamptic patients and monitoring T-cell skewing in vitro. ..
  52. 20-HETE and its interaction with NO in pregnant rats
    Mong Heng Wang; Fiscal Year: 2005
    ..Ultimately, this knowledge can uncover new therapeutic targets and provide novel loci for the control and treatment of pregnancy-induced hypertension. ..
  53. Relationship between Periodontal Disease and Gestational Diabetes Mellitus
    Xu Xiong; Fiscal Year: 2008
    ..Improving oral health and treating periodontal disease before and during pregnancy may reduce maternal and perinatal morbidity associated with GDM and prevent type 2 diabetes after pregnancy. [unreadable] [unreadable] [unreadable]..
  54. Epidemiologic Study of Placental Abruption
    Cande Ananth; Fiscal Year: 2006
    ..It will also add substantial new evidence for associations of several genetic thrombophilias and abruption risk. ..
  55. HYPERHOMOCYSTEINEMIA IN PREGNANCY AND PREECLAMPSIA
    James Roberts; Fiscal Year: 2001
    ..These studies could provide insight into what appears to be a unique sensitivity to endothelial dysfunction during pregnancy and whether acute (during pregnancy) insults are as important as life long exposure. ..
  56. ABNORMAL PRESSURE NATRIURESIS IN HYPERTENSION
    Joey Granger; Fiscal Year: 2009
    ..a decrease in renal medullary production of 20 HETE 3) To test the hypothesis that abnormalities in renal medullary endothelin production and/or ETB receptor function mediate the hypertension in Dahl salt-sensitive rats ..
  57. Renal Microcirculatory and Tubular Dynamics
    Joey Granger; Fiscal Year: 2004
    ....
  58. Maternal overnutrition and offspring fat mass, metabolic and vascular function.
    Debbie Lawlor; Fiscal Year: 2009
    ....
  59. A partially Linear Tree-based Regression Model for Assessing Complex Joint Gene-g
    Jinbo Chen; Fiscal Year: 2008
    ..The second specific aim is to apply the developed method in analyses of several cancer genetic epidemiology studies to explore joint gene-gene or gene-environment interactions. [unreadable] [unreadable] [unreadable]..
  60. VENOARTERIAL SIGNALING IN THE UTERINE CIRCULATION
    George Osol; Fiscal Year: 2003
    ..These studies will provide new, quantitative information on the mechanisms by which molecular signals and pregnancy modulate venous permeability and signal transfer within the uterine circulation. ..