pregnancy in diabetics

Summary

Summary: The state of PREGNANCY in women with DIABETES MELLITUS. This does not include either symptomatic diabetes or GLUCOSE INTOLERANCE induced by pregnancy (DIABETES, GESTATIONAL) which resolves at the end of pregnancy.

Top Publications

  1. ncbi Overweight and the metabolic syndrome in adult offspring of women with diet-treated gestational diabetes mellitus or type 1 diabetes
    Tine D Clausen
    Center for Pregnant Women with Diabetes, Department of Obstetrics, Rigshospitalet, The Capital Region of Denmark, Faculty of Health Sciences, University of Copenhagen, 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 94:2464-70. 2009
  2. ncbi Diabetes mellitus and birth defects
    Adolfo Correa
    Division of Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Am J Obstet Gynecol 199:237.e1-9. 2008
  3. ncbi Perinatal hyperinsulinism as possible predisposing factor for diabetes mellitus, obesity and enhanced cardiovascular risk in later life
    G Dorner
    Bereich Charité der Humboldt Universität, Institut für Experimentelle Endokrinologie, Berlin, Germany
    Horm Metab Res 26:213-21. 1994
  4. ncbi Offspring of diabetic pregnancy: long-term outcomes
    Umberto Simeoni
    INSERM UMR608, Universite de la Mediterranee, France Faculté de Médecine, Universite de la Mediterranee, France Division of Neonatology, Assistance Publique Hopitaux de Marseille, France
    Semin Fetal Neonatal Med 14:119-24. 2009
  5. pmc Obstetric and perinatal outcomes in pregnancies complicated by Type 1 and Type 2 diabetes: influences of glycaemic control, obesity and social disadvantage
    H R Murphy
    Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK
    Diabet Med 28:1060-7. 2011
  6. ncbi Long-term consequences for offspring of diabetes during pregnancy
    F A Van Assche
    Department of Obstetrics and Gynaecology, University Hospital Gasthuisberg, Leuven, Belgium
    Br Med Bull 60:173-82. 2001
  7. pmc Experiences of professional support during pregnancy and childbirth - a qualitative study of women with type 1 diabetes
    Marie Berg
    The Institute of Health and Care Sciences, the Sahlgrenska Academy at Gothenburg University Box 457, SE 405 30, Goteborg, Sweden
    BMC Pregnancy Childbirth 9:27. 2009
  8. ncbi Quality of life in pregnancy and post-partum: a study in diabetic patients
    M G Dalfrà
    DPT Scienze Mediche e Chirurgiche, Universita di Padova, Via Giustiniani 2, 35128, Padova, Italy
    Qual Life Res 21:291-8. 2012
  9. ncbi Maternal-fetal outcome, lipid profile and oxidative stress of diabetic rats neonatally exposed to streptozotocin
    D C Damasceno
    Laboratory of Experimental Research of Gynecology and Obstetrics, Department of Gynecology and Obstetrics, Botucatu Medical School São Paulo State University Unesp, SP, Brazil
    Exp Clin Endocrinol Diabetes 119:408-13. 2011
  10. ncbi Gestational glucose tolerance and risk of type 2 diabetes in young Pima Indian offspring
    Paul W Franks
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Arizona, USA
    Diabetes 55:460-5. 2006

Research Grants

Detail Information

Publications259 found, 100 shown here

  1. ncbi Overweight and the metabolic syndrome in adult offspring of women with diet-treated gestational diabetes mellitus or type 1 diabetes
    Tine D Clausen
    Center for Pregnant Women with Diabetes, Department of Obstetrics, Rigshospitalet, The Capital Region of Denmark, Faculty of Health Sciences, University of Copenhagen, 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 94:2464-70. 2009
    ..In animal studies, exposure to intrauterine hyperglycemia increases the risk of cardiovascular disease through only partly understood epigenetic mechanisms. Human long-term follow-up studies on the same topic are few...
  2. ncbi Diabetes mellitus and birth defects
    Adolfo Correa
    Division of Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Am J Obstet Gynecol 199:237.e1-9. 2008
    ..The purpose of this study was to examine associations between diabetes mellitus and 39 birth defects...
  3. ncbi Perinatal hyperinsulinism as possible predisposing factor for diabetes mellitus, obesity and enhanced cardiovascular risk in later life
    G Dorner
    Bereich Charité der Humboldt Universität, Institut für Experimentelle Endokrinologie, Berlin, Germany
    Horm Metab Res 26:213-21. 1994
    ....
  4. ncbi Offspring of diabetic pregnancy: long-term outcomes
    Umberto Simeoni
    INSERM UMR608, Universite de la Mediterranee, France Faculté de Médecine, Universite de la Mediterranee, France Division of Neonatology, Assistance Publique Hopitaux de Marseille, France
    Semin Fetal Neonatal Med 14:119-24. 2009
    ....
  5. pmc Obstetric and perinatal outcomes in pregnancies complicated by Type 1 and Type 2 diabetes: influences of glycaemic control, obesity and social disadvantage
    H R Murphy
    Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK
    Diabet Med 28:1060-7. 2011
    ..To compare obstetric and perinatal outcomes in women with Type 1 and Type 2 diabetes and relate these to maternal risk factors...
  6. ncbi Long-term consequences for offspring of diabetes during pregnancy
    F A Van Assche
    Department of Obstetrics and Gynaecology, University Hospital Gasthuisberg, Leuven, Belgium
    Br Med Bull 60:173-82. 2001
    ..The long-term consequences of an abnormal intra-uterine environment are of primary importance world-wide. Concentrated efforts are needed to explore how these long-term effects can be prevented...
  7. pmc Experiences of professional support during pregnancy and childbirth - a qualitative study of women with type 1 diabetes
    Marie Berg
    The Institute of Health and Care Sciences, the Sahlgrenska Academy at Gothenburg University Box 457, SE 405 30, Goteborg, Sweden
    BMC Pregnancy Childbirth 9:27. 2009
    ..The aim of this study was to explore the need for and experience of professional support during pregnancy and childbirth among women with type 1 diabetes...
  8. ncbi Quality of life in pregnancy and post-partum: a study in diabetic patients
    M G Dalfrà
    DPT Scienze Mediche e Chirurgiche, Universita di Padova, Via Giustiniani 2, 35128, Padova, Italy
    Qual Life Res 21:291-8. 2012
    ..We evaluated quality of life in pregnant women with diabetes followed up at Italian diabetes clinics...
  9. ncbi Maternal-fetal outcome, lipid profile and oxidative stress of diabetic rats neonatally exposed to streptozotocin
    D C Damasceno
    Laboratory of Experimental Research of Gynecology and Obstetrics, Department of Gynecology and Obstetrics, Botucatu Medical School São Paulo State University Unesp, SP, Brazil
    Exp Clin Endocrinol Diabetes 119:408-13. 2011
    ..There is no evidence about the integrated issue on glycemia, lipid profile, oxidative stress, and anomaly frequency of pregnant diabetic rats neonatally exposed to streptozotocin...
  10. ncbi Gestational glucose tolerance and risk of type 2 diabetes in young Pima Indian offspring
    Paul W Franks
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Arizona, USA
    Diabetes 55:460-5. 2006
    ..Thus, prevention of offspring type 2 diabetes may require strategies that focus on improving gestational glucose tolerance even within the normal range...
  11. pmc Effect of gestational weight gain on perinatal outcomes in women with type 2 diabetes mellitus using the 2009 Institute of Medicine guidelines
    Lynn M Yee
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, CA, USA
    Am J Obstet Gynecol 205:257.e1-6. 2011
    ..We sought to examine associations between gestational weight gain according to the 2009 Institute of Medicine (IOM) guidelines and perinatal outcomes in overweight/obese women with type 2 diabetes mellitus (T2DM)...
  12. ncbi Hypoglycaemia during pregnancy in women with Type 1 diabetes
    L Ringholm
    Center for Pregnant Women with Diabetes, Rigshospitalet, University of Copenhagen Department of Endocrinology, Rigshospitalet, Copenhagen, Denmark
    Diabet Med 29:558-66. 2012
    ..To explore incidence, risk factors, possible pathophysiological factors and clinical management of hypoglycaemia during pregnancy in women with Type 1 diabetes...
  13. ncbi Pre-pregnancy weight and the risk of stillbirth and neonatal death
    Janni Kristensen
    Perinatal Epidemiological Research Unit, Department of Obstetrics and Gynaecology, Aarhus University Hospital, 8200 Aarhus N, Denmark
    BJOG 112:403-8. 2005
    ..To evaluate the association between maternal pre-pregnancy body mass index (BMI) and the risk of stillbirth and neonatal death and to study the causes of death among the children...
  14. ncbi Long-term effects of the intrauterine environment, birth weight, and breast-feeding in Pima Indians
    D J Pettitt
    Diabetes and Arthritis Epidemiology Section, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, USA
    Diabetes Care 21:B138-41. 1998
    ....
  15. pmc Maternal efficacy and safety outcomes in a randomized, controlled trial comparing insulin detemir with NPH insulin in 310 pregnant women with type 1 diabetes
    Elisabeth R Mathiesen
    Center for Pregnant Women with Diabetes, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Diabetes Care 35:2012-7. 2012
    ..This randomized, controlled noninferiority trial aimed to compare the efficacy and safety of insulin detemir (IDet) versus neutral protamine Hagedorn (NPH) (both with prandial insulin aspart) in pregnant women with type 1 diabetes...
  16. ncbi Secretory IgA-Fcα receptor interaction modulating phagocytosis and microbicidal activity by phagocytes in human colostrum of diabetics
    Eduardo Luzia França
    Post Graduate Program in Immunology and Parasitology of the Institute of Biological and Health Sciences, Federal University of Mato Grosso, Barra do Garças, MT, Brazil
    APMIS 119:710-9. 2011
    ..The stimulatory effects of SIgA on the functional activity of phagocytes therefore protect infants, especially of diabetic women, against intestinal infections...
  17. pmc Exposure to maternal diabetes induces salt-sensitive hypertension and impairs renal function in adult rat offspring
    Touria Nehiri
    Institut National de la Sante et de la Recherche Medicale, Unite Mixte de Recherche S872, Centre de Recherche des Cordeliers, Paris, France
    Diabetes 57:2167-75. 2008
    ..The aim of the study was to assess, in the rat, long-term effects of in utero exposure to maternal diabetes on blood pressure and renal function in adulthood...
  18. ncbi Gestational diabetes guidelines in a HAPO world
    Joyce Leary
    UC Davis Medical Center, Department of Internal Medicine, Sacramento, CA 95817, USA
    Best Pract Res Clin Endocrinol Metab 24:673-85. 2010
    ..Regardless, these guidelines serve to advance the discussion on appropriate screening and diagnosis of diabetes in pregnancy...
  19. ncbi The diabetic pregnancy and offspring BMI in childhood: a systematic review and meta-analysis
    L H Philipps
    Section of Neonatal Medicine, Department of Medicine, Imperial College London, Chelsea and Westminster Campus, 369 Fulham Road, London, SW10 9NH, UK
    Diabetologia 54:1957-66. 2011
    ..Increased offspring BMI is a plausible mediator. We performed a systematic review and meta-analysis of studies examining offspring BMI z score in childhood in relation to maternal diabetes...
  20. pmc Intrauterine exposure to diabetes is a determinant of hemoglobin A(1)c and systolic blood pressure in pima Indian children
    Joy C Bunt
    Obesity and Clinical Diabetes Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 North 16th Street, Room 541 A, Phoenix, Arizona 85016, USA
    J Clin Endocrinol Metab 90:3225-9. 2005
    ....
  21. ncbi Fetal cardiac effects of maternal hyperglycemia during pregnancy
    Niamh Corrigan
    UCD School of Medicine and Medical Science, University College, Dublin 2, Ireland
    Birth Defects Res A Clin Mol Teratol 85:523-30. 2009
    ..In this review, we will summarize recent data on fetal cardiac effects from human pregestational diabetic mothers, as well as the most relevant findings in rodent models of diabetic cardiac teratogenesis...
  22. ncbi Trends in prevalence and outcomes of pregnancy in women with pre-existing type I and type II diabetes
    R Bell
    Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK
    BJOG 115:445-52. 2008
    ..To describe recent trends in prevalence, outcomes and indicators of care for women with pre-existing type I or type II diabetes...
  23. ncbi Type 2 diabetes in pregnancy: a growing concern
    Denice S Feig
    Division of Endocrinology and Metabolism, Mount Sinai Hospital, Ontario M5G 1X5, Toronto, Canada
    Lancet 359:1690-2. 2002
  24. pmc Maternal glucose at 28 weeks of gestation is not associated with obesity in 2-year-old offspring: the Belfast Hyperglycemia and Adverse Pregnancy Outcome (HAPO) family study
    David J Pettitt
    Sansum Diabetes Research Institute, Santa Barbara, California, USA
    Diabetes Care 33:1219-23. 2010
    ..K. center of the multinational Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study...
  25. ncbi Continuous glucose monitoring for the evaluation of gravid women with type 1 diabetes mellitus
    Yariv Yogev
    Department of Obstetrics and Gynecology, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel
    Obstet Gynecol 101:633-8. 2003
    ..To compare the daily glycemic profile reflected by continuous and intermittent blood glucose monitoring in pregnant women with type 1 diabetes and to compare the treatment protocols based on the two monitoring methods...
  26. ncbi Animal models in diabetes and pregnancy
    Alicia Jawerbaum
    Laboratory of Reproduction and Metabolism, Centro de Estudios Farmacológicos y Botánicos Consejo Nacional de Investigaciones Científicas y Técnicas School of Medicine, University of Buenos Aires, Buenos Aires, Argentina
    Endocr Rev 31:680-701. 2010
    ....
  27. ncbi Type 2 diabetes in pregnancy - An increasing problem
    Rosemary Temple
    Elsie Bertram Diabetes Centre, Norfolk and Norwich University Hospital NHS Trust, Norwich, Norfolk, United Kingdom
    Best Pract Res Clin Endocrinol Metab 24:591-603. 2010
    ....
  28. pmc Closed-loop insulin delivery during pregnancy complicated by type 1 diabetes
    Helen R Murphy
    Institute of Metabolic Science, Metabolic Research Laboratories, University of Cambridge, Hills Road, Cambridge, UK
    Diabetes Care 34:406-11. 2011
    ..This study evaluated closed-loop insulin delivery with a model predictive control (MPC) algorithm during early (12-16 weeks) and late gestation (28-32 weeks) in pregnant women with type 1 diabetes...
  29. ncbi Oxidative stress status and lipid profiles of diabetic pregnant rats exposed to cigarette smoke
    Maricelma da Silva Soares de Souza
    Laboratory of Experimental Research of Gynecology and Obstetrics, Department of Gynecology and Obstetrics, Botucatu Medical School, Unesp Univ Estadual Paulista, Sao Paulo State, Brazil
    Reprod Biomed Online 20:547-52. 2010
    ....
  30. pmc Serum carotenoids and fat-soluble vitamins in women with type 1 diabetes and preeclampsia: a longitudinal study
    Madona Azar
    Harold Hamm Oklahoma Diabetes Center and Section of Endocrinology and Diabetes, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    Diabetes Care 34:1258-64. 2011
    ..Prospective measures of fat-soluble vitamins in diabetic pregnancy are therefore of interest...
  31. ncbi Risk factors for macrosomia and its clinical consequences: a study of 350,311 pregnancies
    Matthew C Jolly
    Section of Endocrinology and Metabolic Medicine, The Mint Wing, Imperial College of Science Technology and Medicine, St Mary s Campus, London W2 1PG, UK
    Eur J Obstet Gynecol Reprod Biol 111:9-14. 2003
    ..To identify demographic risk factors for either birthweight >4kg or over the 90th centile and to quantify the obstetric risks...
  32. ncbi Cardiac malformations and alteration of TGFbeta signaling system in diabetic embryopathy
    Zhiyong Zhao
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, 21201, USA
    Birth Defects Res B Dev Reprod Toxicol 89:97-105. 2010
    ..Cardiovascular defects are the most common anomalies in diabetic embryopathy. The mechanisms underlying the manifestation of the defects remain to be addressed...
  33. ncbi Comparison of pregnancy mood profiles in gestational diabetes and preexisting diabetes
    N Langer
    Fordham University, School of Social Work, New York, USA
    Diabetes Educ 26:667-72. 2000
    ..mood profile? Is there a relationship between levels of glycemic control and emotional profile? Which factors distinguish the emotional profile of women with pregestational diabetes from women with newly diagnosed gestational diabetes?..
  34. ncbi Pathogenesis of diabetes-induced congenital malformations
    U J Eriksson
    Department of Medical Cell Biology, Uppsala University, Sweden
    Ups J Med Sci 105:53-84. 2000
    ....
  35. ncbi The prevalence of maternal medical conditions during pregnancy and a validation of their reporting in hospital discharge data
    Ruth M Hadfield
    Perinatal Research, The Kolling Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia
    Aust N Z J Obstet Gynaecol 48:78-82. 2008
    ..We estimated the population prevalence of maternal medical conditions during pregnancy and found a tendency towards underreporting although specificities were high, indicating that false positives were uncommon...
  36. pmc Internet use, needs and expectations of web-based information and communication in childbearing women with type 1 diabetes
    Carina Sparud-Lundin
    Institute of Health and Care Sciences, the Sahlgrenska Academy at University of Gothenburg, Box 457, SE 405 30, Gothenburg, Sweden
    BMC Med Inform Decis Mak 11:49. 2011
    ..The objective of this study was to explore internet use, needs, and expectations regarding web-based information and communication in childbearing women with type 1 diabetes...
  37. pmc One-cell zygote transfer from diabetic to nondiabetic mouse results in congenital malformations and growth retardation in offspring
    Amanda Wyman
    Department of Obstetrics and Gynecology, Washington University in St Louis, St Louis, MO 63110, USA
    Endocrinology 149:466-9. 2008
    ..5. In summary, exposure to maternal diabetes during oogenesis, fertilization, and the first 24 h was enough to program permanently the fetus to develop significant morphological changes...
  38. ncbi Congenital anomalies in diabetic pregnancy
    Ulf J Eriksson
    Department of Medical Cell Biology, Uppsala University, Biomedical Center, PO Box 571, SE 75123 Uppsala, Sweden
    Semin Fetal Neonatal Med 14:85-93. 2009
    ....
  39. ncbi Fetal and neonatal outcomes of diabetic pregnancies
    Joanne Yang
    Department of Pediatrics, Izaak Walton Killam Health Centre and Dalhousie University, Halifax, Nova Scotia, Canada
    Obstet Gynecol 108:644-50. 2006
    ....
  40. ncbi Associations of Type 1 diabetes mellitus, maternal vascular disease and complications of pregnancy
    C Howarth
    Queen s Medical Centre, Nottingham University Hospitals, Nottingham, UK
    Diabet Med 24:1229-34. 2007
    ..Maternal diabetes increases the risk of pre-eclampsia and abnormalities of fetal growth. We studied the additional impact of maternal vascular disease on these risks...
  41. ncbi Treatment with Azadirachta indica in diabetic pregnant rats: negative effects on maternal outcome
    Bruna Dallaqua
    Laboratory of Experimental Research on Gynecology and Obstetrics, Postgraduation Program in Gynecology, Obstetrics and Mastology, Botucatu Medical School, Universidade Estadual Paulista UNESP, Sao Paulo State, Brazil
    J Ethnopharmacol 143:805-11. 2012
    ..The objective of this study was to evaluate the effects of Azadirachta indica (neem) on maternal reproductive performance and biochemical parameters in non-diabetic and streptozotocin-induced mild diabetic rats (MD)...
  42. ncbi Women with diabetes in pregnancy: different perceptions and expectations
    Jean M Lawrence
    Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, 91101, USA
    Best Pract Res Clin Obstet Gynaecol 25:15-24. 2011
    ..We present information about how health professionals may manage these perceptions and expectations, based on the findings of these studies, as well as areas for future research...
  43. ncbi Maternal adjustment and infant outcome in medically defined high-risk pregnancy
    Rachel Levy-Shiff
    Department of Psychology, Bar Ilan University, Ramat Gan, Israel
    Dev Psychol 38:93-103. 2002
    ..Infant outcomes in the maternal diabetic groups were associated with maternal metabolism. Maternal coping and resources differed in the 3 groups and differentially predicted infant development...
  44. ncbi Current perspectives on the causes of neural tube defects resulting from diabetic pregnancy
    Mary R Loeken
    Section on Developmental and Stem Cell Biology at Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Am J Med Genet C Semin Med Genet 135:77-87. 2005
    ..Evidence in support of this model, in which excess glucose metabolism inhibits expression of Pax3, thereby derepressing p53-dependent apoptosis of neuroepithelium and leading to NTD will be discussed...
  45. ncbi Insulin during pregnancy, labour and delivery
    Harold W de Valk
    Dept of Internal Medicine, University Medical Centre Utrecht, The Netherlands
    Best Pract Res Clin Obstet Gynaecol 25:65-76. 2011
    ..After delivery, glycaemic control must be relaxed to prevent hypoglycaemia, especially in women who breastfeed...
  46. ncbi Preconception care: a systematic review
    Carol C Korenbrot
    Institute for Health Policy Studies, University of California, San Francisco 94143 0936, USA
    Matern Child Health J 6:75-88. 2002
    ....
  47. ncbi N-3 fatty acids modulate antioxidant status in diabetic rats and their macrosomic offspring
    A Yessoufou
    Department of Physiology, UPRES Lipids and Nutrition, Faculty of Life Sciences, University of Burgundy, Dijon, France
    Int J Obes (Lond) 30:739-50. 2006
    ..We investigated the role of dietary n-3 polyunsaturated fatty acids (n-3 PUFA) in the modulation of total antioxidant status in streptozotocin (STZ)-induced diabetic rats and their macrosomic offspring...
  48. ncbi Long-term effects of maternal diabetes on vascular reactivity and renal function in rat male offspring
    Silvia O Rocha
    Department of Physiology, Federal University of Sao Paulo, Brazil
    Pediatr Res 58:1274-9. 2005
    ....
  49. ncbi Intrauterine diabetes exposure and the risk of renal disease in diabetic Pima Indians
    R G Nelson
    Phoenix Epidemiology and Clinical Research Branch, National Insitute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85014 4972, USA
    Diabetes 47:1489-93. 1998
    ..The effect of this exposure appears to be independent of other susceptibility factors that lead to nephropathy in diabetes...
  50. ncbi A qualitative study of perceived barriers to management of diabetes among women with a history of diabetes during pregnancy
    Sarah A Collier
    Atlanta Research and Education Foundation contractor for Centers for Disease Control and Prevention CDC, National Center for Emerging and Zoonotic Infectious Diseases NCEZID, Atlanta, Georgia 30333, USA
    J Womens Health (Larchmt) 20:1333-9. 2011
    ..This study explored barriers to glycemic control before, during, and after pregnancy and describes knowledge, attitudes, and behaviors among pregnant women with pregestational diabetes (PGDM) or gestational diabetes (GDM)...
  51. pmc Vascular dysfunction in the diabetic placenta: causes and consequences
    Lopa Leach
    School of Biomedical Sciences, Centre for Integrated Systems Biology and Medicine, Institute of Clinical Research, Faculty of Medicine and Health Sciences, University of Nottingham, UK
    J Anat 215:69-76. 2009
    ..The altered molecular mechanisms underlying the vascular changes in the diabetic human placenta may reflect similar consequences of high glucose and hyperinsulinaemia...
  52. ncbi Maternal hyperglycemia alters glucose transport and utilization in mouse preimplantation embryos
    K H Moley
    Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Physiol 275:E38-47. 1998
    ..These findings suggest that, in response to a maternal diabetic state, preimplantation mouse embryos experience a decrease in glucose utilization directly related to a decrease in glucose transport at both the mRNA and protein levels...
  53. pmc Type 1 diabetes and pregnancy
    Roy Taylor
    Newcastle University, and Royal Victoria Infirmary, Newcastle upon Tyne
    BMJ 334:742-5. 2007
  54. ncbi Transgenic mice overproducing human thioredoxin-1, an antioxidative and anti-apoptotic protein, prevents diabetic embryopathy
    Y Kamimoto
    Department of Obstetrics and Gynecology, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    Diabetologia 53:2046-55. 2010
    ..Using transgenic mice that overproduce human TRX-1 (TRX-Tg mice), we examined whether oxidative stress is involved in fetal dysmorphogenesis in diabetic pregnancies...
  55. ncbi Pregnancy in women with Type 2 diabetes: 12 years outcome data 1990-2002
    F Dunne
    Department of Medicine, Division of Medical Sciences, University of Birmingham and Birmingham Women s Hospital Trust, Birmingham, UK
    Diabet Med 20:734-8. 2003
    ..Twelve years' outcome analysis of pregnancies in women with Type 2 diabetes in a multiethnic geographically defined area...
  56. ncbi Effect of Ginkgo biloba on the reproductive outcome and oxidative stress biomarkers of streptozotocin-induced diabetic rats
    M V C Rudge
    Laboratório de Pesquisa Experimental de Ginecologia e Obstetrícia, Departamento de Ginecologia e Obstetricia, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, 18618 000 Botucato, SP, Brazil
    Braz J Med Biol Res 40:1095-9. 2007
    ....
  57. ncbi Pregnancy-induced sight-threatening diabetic retinopathy in women with Type 1 diabetes
    M Vestgaard
    Copenhagen Centre for Pregnant Women with Diabetes, Department of Endocrinology, Rigshospitalet, Faculty of Health Sciences, Copenhagen, Denmark
    Diabet Med 27:431-5. 2010
    ..To determine the progression of diabetic retinopathy in pregnant women with diabetes offered tight glycaemic and blood pressure control...
  58. pmc Perinatal mortality and congenital anomalies in babies of women with type 1 or type 2 diabetes in England, Wales, and Northern Ireland: population based study
    Mary C M Macintosh
    Confidential Enquiry into Maternal and Child Health, London NW1 5SD
    BMJ 333:177. 2006
    ..To provide perinatal mortality and congenital anomaly rates for babies born to women with type 1 or type 2 diabetes in England, Wales, and Northern Ireland...
  59. ncbi Secular trends in birth weight, BMI, and diabetes in the offspring of diabetic mothers
    R S Lindsay
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Health, Phoenix, Arizona 85014, USA
    Diabetes Care 23:1249-54. 2000
    ..We hypothesized that, in light of the historical improvements in the management of diabetes during pregnancy, these late consequences of the early environment might be diminishing with time...
  60. pmc Effectiveness of a regional prepregnancy care program in women with type 1 and type 2 diabetes: benefits beyond glycemic control
    Helen R Murphy
    Institute of Metabolic Science, University of Cambridge, Cambridge, UK
    Diabetes Care 33:2514-20. 2010
    ..To implement and evaluate a regional prepregnancy care program in women with type 1 and type 2 diabetes...
  61. pmc Obstetric and perinatal outcomes in type 1 diabetic pregnancies: A large, population-based study
    Martina Persson
    Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm, Sweden
    Diabetes Care 32:2005-9. 2009
    ..To perform comparative analyses of obstetric and perinatal outcomes between type 1 diabetic pregnancies and the general obstetric population in Sweden between 1991 and 2003...
  62. ncbi Diabetes in pregnancy: a review of current evidence
    Nisha Kapoor
    Maternal Medicine Unit, Epsom and St Helier University Hospitals NHS Trust, Surrey, UK
    Curr Opin Obstet Gynecol 19:586-90. 2007
    ..The results were exceptionally poor, suggesting the need for a new management approach. The aim of this review is to address these findings and our suggested care pathways...
  63. ncbi Macrosomic newborns of diabetic mothers are associated with increased aortic intima-media thickness and lipid concentrations
    Mustafa Akcakus
    Division of Neonatology, Department of Paediatrics, Erciyes University School of Medicine, Kayseri, Turkey
    Horm Res 67:277-83. 2007
    ..We aimed to investigate relationship between abdominal aortic intima-media thickness (aIMT), LV mass and lipid profile in macrosomic newborns...
  64. ncbi Hyperglycemia: its imminent effects on mammalian nephrogenesis
    Yashpal S Kanwar
    Department of Pathology, Northwestern University Medical School, Chicago, IL, USA
    Pediatr Nephrol 20:858-66. 2005
    ..The latter findings suggest that disruption of epithelial:mesenchymal interactions may be the major event responsible for the metanephric dysmorphogenesis induced by high glucose ambience...
  65. pmc Preconception care of women with diabetes: a review of current guideline recommendations
    Maimunah Mahmud
    Department of General Practice, School of Primary Health Care, Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria, Australia
    BMC Womens Health 10:5. 2010
    ....
  66. ncbi Women's perceptions of being pregnant and having pregestational diabetes
    Tina Lavender
    University of Manchester, School of Nursing, Midwifery and Social Work, Oxford Road, Manchester M13 9PL, UK
    Midwifery 26:589-95. 2010
    ..to explore the experiences of White British and South East Asian women with type 1 and type 2 diabetes, and the perceived impact of diabetes on their reproductive health...
  67. ncbi Hypoglycemia rates in the first days of life among term infants born to diabetic mothers
    Ayala Maayan-Metzger
    Department of Neonatology, The Edmond and Lili Safra Children s Hospital, Sheba Medical Center, Ramat Gan and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Neonatology 96:80-5. 2009
    ..To discover the risk factors for developing hypoglycemia in newborns born to diabetic mothers and to characterize the rates of glucose concentrations in the first two days of life...
  68. ncbi Animal evidence for the transgenerational development of diabetes mellitus
    L Aerts
    Department of Developmental Biology, UZ Gasthuisberg, KULeuven, Belgium
    Int J Biochem Cell Biol 38:894-903. 2006
    ..The concept of fetal origin of adult diabetes therefore is of major significance for public health in the immediate and the far future...
  69. pmc Insulin resistance and impaired pancreatic β-cell function in adult offspring of women with diabetes in pregnancy
    Louise Kelstrup
    Center for Pregnant Women with Diabetes, Department of Obstetrics, Research Unit 7821, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 98:3793-801. 2013
    ..Offspring of women with diabetes during pregnancy have an increased risk of glucose intolerance in adulthood, but the underlying mechanisms are unknown...
  70. ncbi Apoptosis and its pathway in early post-implantation embryos of diabetic rats
    Fuyan Sun
    Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital of Medicine and Dentistry, Nagasaki, Japan
    Diabetes Res Clin Pract 67:110-8. 2005
    ..These results suggest that a Bax-regulated mitochondrial cytochrome c-mediated caspase-3 activation pathway might be involved in the diabetic embryopathy...
  71. ncbi Maternal diabetes: effects on embryonic vascular development--a vascular endothelial growth factor-A-mediated process
    Joseph A Madri
    Department of Pathology, Yale University School of Medicine, 310 Cedar Street, P O Box 208023, New Haven, CT 06520 8023, USA
    Pediatr Dev Pathol 6:334-41. 2003
    ..Further understanding of the effects of maternal diabetes on yolk sac and embryonic vasculogenesis/angiogenesis and organogenesis may lead to novel approaches in treating and preventing major birth defects...
  72. ncbi 'Programming' of orexigenic and anorexigenic hypothalamic neurons in offspring of treated and untreated diabetic mother rats
    Kerstin Franke
    Clinic of Obstetrics, Division of Experimental Obstetrics, Charite University Medicine Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
    Brain Res 1031:276-83. 2005
    ..These acquired alterations are preventable by treatment of maternal GD...
  73. ncbi Maternal risk factors for congenital urinary anomalies: results of a population-based case-control study
    Margarett Shnorhavorian
    Department of Urology, University of Washington School of Medicine, Seattle, WA, USA
    Urology 78:1156-61. 2011
    ..The purpose of this study was to examine the association between maternal risk factors and CUTA in a population-based case-control study...
  74. ncbi French multicentric survey of outcome of pregnancy in women with pregestational diabetes
    Pierre Boulot
    Diabetes Care 26:2990-3. 2003
    ..To evaluate perinatal outcome in pregnancies in women with type 1 and type 2 diabetes and the influence of preconception care 10 years after the St. Vincent's declaration...
  75. ncbi Factors influencing pregnancy outcome in women with type 2 versus type 1 diabetes mellitus
    Nieves Luisa Gonzalez-Gonzalez
    Department of Obstetrics and Gynecology, University Hospital of the Canary Islands, Tenerife, Spain
    Acta Obstet Gynecol Scand 87:43-9. 2008
    ..To compare pregnancy outcome and factors related to adverse perinatal outcome in women with type 1 versus type 2 diabetes mellitus (DM)...
  76. ncbi Outcomes of pregnancies in women with pre-existing type 1 or type 2 diabetes, in an ethnically mixed population
    Evelyn C J Verheijen
    Obstetrics and Gynaecology Department, Bradford Royal Infirmary, Duckworth Lane Bradford, West Yorkshire, UK
    BJOG 112:1500-3. 2005
    ..To compare the outcomes of pregnancies in women with pre-existing, type 1 and type 2, diabetes and to examine the influence of ethnicity on these outcomes...
  77. ncbi Hyperglycemia and apoptosis: mechanisms for congenital malformations and pregnancy loss in diabetic women
    K H Moley
    Dept of Obstetrics and Gynecology, Washington University, St Louis, MO 63110, USA
    Trends Endocrinol Metab 12:78-82. 2001
    ....
  78. ncbi Leptin concentrations in maternal serum and cord blood in diabetic and nondiabetic pregnancy
    John G Manderson
    Royal Jubilee Maternity Hospital, Royal Victoria Hospital, Belfast, Northern Ireland, UK
    Am J Obstet Gynecol 188:1326-32. 2003
    ..The purpose of this study was to examine the relationships between maternal and cord leptin concentrations, maternal and neonatal outcomes, and measures of glycemic control in diabetic and nondiabetic pregnancy...
  79. ncbi Maternal diabetes and renal agenesis/dysgenesis
    Erin M Davis
    The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Birth Defects Res A Clin Mol Teratol 88:722-7. 2010
    ....
  80. ncbi Type 2 diabetes in pregnancy: a wolf in sheep's clothing
    N Wah Cheung
    Centre for Diabetes and Endocrinology Research, Westmead Hospital, University of Sydney, Sydney, New South Wales, Australia
    Aust N Z J Obstet Gynaecol 45:479-83. 2005
    ..There is a need to highlight the dangers of type 2 diabetes in pregnancy to both patients and medical practitioners. Peri-conception care needs to improve to achieve better pregnancy outcomes...
  81. ncbi Diabetes mellitus in the First Nations population of British Columbia, Canada. Part 2. Hospital morbidity
    Andrew Jin
    Health Canada, First Nations and Inuit Health Branch, Pacific Region, Vancouver, Canada
    Int J Circumpolar Health 61:254-9. 2002
    ..To describe hospitalization rates from diabetes mellitus or its complications among residents of the province of British Columbia, Canada during the 5-year period 1993 to 1997, comparing people with Indian Status to rest of the population...
  82. ncbi Maternal hypoglycemia during pregnancy in type 1 diabetes: maternal and fetal consequences
    Edith W M T ter Braak
    Department of Internal Medicine and Endocrinology, University Medical Center, Utrecht, The Netherlands
    Diabetes Metab Res Rev 18:96-105. 2002
    ..Efforts must be made to avoid low BG, i.e. <3.9 mmol/l, when tightening glycemic control...
  83. ncbi Increasing rate of diabetes in pregnancy among American Indian and white mothers in Montana and North Dakota, 1989-2000
    Kathleen R Moum
    North Dakota Diabetes Prevention and Control Program, North Dakota Department of Health, Bismarck, North Dakota, USA
    Matern Child Health J 8:71-6. 2004
    ..The purpose of this study was to assess trends in diabetes in pregnancy in American Indian and whites mothers in Montana and North Dakota...
  84. ncbi Intensive glycemic control in diabetic pregnancy with intrauterine growth restriction is detrimental to fetus
    Rakesh M Parikh
    Department of Endocrinology, Seth GS Medical College and KEM Hospital, Parel, Mumbai 400 012, India
    Med Hypotheses 69:203-5. 2007
    ..Neonatal metabolic complications can be avoided by strict glycemic control during last two weeks of pregnancy...
  85. ncbi Management of diabetes in pregnancy
    Jerasimos Ballas
    Reproductive Medicine Department, University of California San Diego, 200 West Arbor Drive, San Diego, CA, USA
    Curr Diab Rep 12:33-42. 2012
    ..This article emphasizes the newest guidelines for diabetes screening in pregnancy while reviewing their potential impact on maternal and neonatal complications that arise in the setting of hyperglycemia in pregnancy...
  86. ncbi Growth hormone binding protein and maternal body mass index in relation to placental growth hormone and insulin requirements during pregnancy in type 1 diabetic women
    Jens Fuglsang
    Gynecological Obstetrical Research laboratory Y, Aarhus University Hospital, Skejby Sygehus, DK 8200 Aarhus N, Denmark
    Growth Horm IGF Res 15:223-30. 2005
    ..The well-known association between GHBP and BMI was lost in late pregnancy. Calculated levels of free PGH were positively associated to fetal growth, but not to maternal insulin requirements...
  87. ncbi Impact of maternal diabetes mellitus on mortality and morbidity of preterm infants (24-33 weeks' gestation)
    Yoram Bental
    Department of Neonatology, Laniado Hospital, Divrei Chaim St, Netanya 42150, Israel
    Pediatrics 128:e848-55. 2011
    ..We hypothesized that maternal diabetes mellitus (DM) increases the risk for mortality, respiratory distress syndrome (RDS), and major complications of prematurity...
  88. ncbi Prevalence and risk factors of cesarean section in a population of Tunisian diabetic pregnant women
    Walid Denguezli
    Department of Obstetric and Gynaecology, Fattouma Bourguiba reaching Hospital Monastir Tunisia
    Tunis Med 85:935-40. 2007
    ..To determine the rate of and indication of cesarean section among women with preexisting and gestational diabetes mellitus compared with glucose-tolerant women...
  89. ncbi Association between 5 min Apgar scores and planned mode of delivery in diabetic pregnancies
    Andrea E Stuart
    Department of Obstetrics and Gynecology, Central Hospital, Helsingborg, Sweden
    Acta Obstet Gynecol Scand 90:325-31. 2011
    ..Due to the high incidence of neonatal complications in diabetic pregnancies, the aim of our study was to investigate whether elective cesarean section could prevent adverse neonatal outcome...
  90. ncbi A comparison of foetal and labour outcomes in Caucasian and Afro-Caribbean women with diabetes in pregnancy
    T Chaudhry
    Department of Medicine, University of Birmingham, Birmingham, UK
    Int J Clin Pract 58:932-6. 2004
    ..Variations in culture or access to health care may account for these differences. An awareness of the specific needs of ethnic minorities is essential to ensure that this encouraging trend continues...
  91. ncbi High glucose promotes nascent nephron apoptosis via NF-kappaB and p53 pathways
    Yun Wen Chen
    Universite de Montreal, Centre de recherche du Centre Hospitalier de l Universite de Montreal, CRCHUM, Hopital Hotel Dieu, Pavillon Masson, 3850 Saint Urbain St, Montreal, Quebec, Canada H2W 1T7
    Am J Physiol Renal Physiol 300:F147-56. 2011
    ..Our data demonstrate that high glucose-induced nascent nephron apoptosis is mediated, at least in part, via ROS generation and the activation of NF-κB and p53 pathways...
  92. pmc Trends and disparities among diabetes-complicated births in Minnesota, 1993-2003
    Heather M Devlin
    Minnesota Diabetes Program, Minnesota Department of Health, PO Box 64882, St Paul, MN 55164 0882, USA
    Am J Public Health 98:59-62. 2008
    ..8, respectively). Increases were significant in all demographic groups except gestational diabetes among American Indian mothers, and disparities worsened among all groups. Targeted interventions and surveillance improvements are needed...
  93. ncbi Use of insulin pumps in pregnancies complicated by type 2 diabetes and gestational diabetes in a multiethnic community
    D Simmons
    Department of Rural Health, University of Melbourne, Shepparton, Victoria, Australia
    Diabetes Care 24:2078-82. 2001
    ..To describe the use of insulin pump therapy in women with gestational diabetes mellitus (GDM) or type 2 diabetes in pregnancy and persistent hyperglycemia despite multiple injections of subcutaneous insulin...
  94. ncbi [Gestational diabetes and urinary tract malformations: a hospital case-control study]
    Arnaud Fotso Kamdem
    Service de Chirurgie Pédiatrique et Orthopédique, Hopital Saint Jacques, Besancon, France
    Prog Urol 15:53-8. 2005
    ..The purpose of this study was to assess the role of insulin-requiring gestational diabetes on the development of ureteric malformations in children...
  95. ncbi Perinatal outcomes and macrosomia in a multi-ethnic population of women with type 2 diabetes
    Ruth Hughes
    Department of General Medicine, Christchurch Hospital, Christchurch, New Zealand
    Aust N Z J Obstet Gynaecol 46:552-5. 2006
    ..Asian women had significantly smaller babies and lower rates of macrosomia as defined by standard growth charts. Other outcomes were similar between the Asian, European and Polynesian women...
  96. ncbi Intrauterine growth retardation in experimental diabetes: possible role of the placenta
    R Padmanabhan
    Department of Anatomy, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
    Arch Physiol Biochem 109:260-71. 2001
    ..The consistent association of placental pathology with fetal growth retardation is suggestive of an alteration in placental function possibly contributing to IUGR in STZ-induced diabetes in rats...
  97. ncbi The effect of pregnancy on the natural history of diabetic retinopathy and nephropathy
    J Star
    Division of Maternal Fetal Medicine, Women and Infants Hospital, Brown University School of Medicine, Providence, Rhode Island, USA
    Clin Perinatol 25:887-916. 1998
    ..Fortunately, with intensive medical surveillance and appropriate interventions, most women with types 1 and 2 diabetes mellitus can be offered an optimistic prognosis for child bearing...
  98. ncbi A review of maternal and fetal growth factors in diabetic pregnancy
    Mary Higgins
    University College Dublin School of Medicine and Medical Science, Obstetrics and Gynaecology, National Materntity Hospital, Dublin 2, Ireland
    Curr Diabetes Rev 6:116-25. 2010
    ..It is now evident that control of fetal growth, in normal as well as diabetic pregnancies, is far more complex than previously thought...
  99. ncbi Prevention of gestational diabetes mellitus: a review of studies on weight management
    Anne Sophie Morisset
    Endocrinology and Genomics, Laval University Medical Research Center, Quebec City, Quebec, Canada
    Diabetes Metab Res Rev 26:17-25. 2010
    ..Further studies are required to identify the most effective diet composition to prevent GDM and excessive gestational weight gain...
  100. ncbi Risk indicators predictive for severe hypoglycemia during the first trimester of type 1 diabetic pregnancy
    Inge M Evers
    Department of Obstetrics, Utrecht University, University Medical Center, Utrecht, The Netherlands
    Diabetes Care 25:554-9. 2002
    ....
  101. ncbi Juggling type 1 diabetes and pregnancy in rural Australia
    Rosemary King
    School of Nursing, University of Ballarat, PO Box 663, Ballarat, 3353, Victoria, Australia
    Midwifery 25:126-33. 2009
    ..Additionally, we aimed to describe the women's engagement with, and expectations of, health-care providers during this period, and subsequently highlight potential service and informational gaps...

Research Grants38

  1. A Run-to-Run Algorithm for Glucose Regulation
    Lois Jovanovic; Fiscal Year: 2005
    ..The exchange of personnel will be facilitated, allowing the student and post-doc supported on this project to work at both the institute and the university over the span of the project ..
  2. Sub Clinical Cardiovascular Disease in Youth (SEARCH CVD)
    Dana Dabelea; Fiscal Year: 2010
    ..This study will advance our understanding of the natural history of early CVD in youth, and will provide insights into the mechanisms from which strategies to prevent or limit vascular disease in individuals with T1D can be developed. ..
  3. Pathobiology of HMG-CoA reductase inhibitors in diabetes
    Yashpal Kanwar; Fiscal Year: 2006
    ....
  4. GLOMERULAR CAPILLARY WALL--NORMAL AND PATHOLOGIC
    Yashpal Kanwar; Fiscal Year: 2008
    ..Null alleles will be interbred to generate Null -/- mutant as a conventional KO mice with ablation of the TIN-ag gene. ..
  5. PROMOTING HEALTHY LIFESTYLES AMONG WOMEN
    Edith Kieffer; Fiscal Year: 2006
    ..Measures will be collected at 10-14 weeks, -26 weeks and -36 weeks of gestation and -6 weeks postpartum. ..
  6. Pregnancy and Risk Factors for CVD and Type 2 Diabetes
    Erica Gunderson; Fiscal Year: 2006
    ..The study will also assess whether breastfeeding has beneficial effects on risk factors that may help prevent heart disease and diabetes in women. ..
  7. Improving Outcomes in Underserved Women with GDM
    Carol Homko; Fiscal Year: 2007
    ..We expect that Telemonitoring will improve maternal glucose control and lead to reductions in birth weight. [unreadable] [unreadable] [unreadable]..
  8. MOLECULAR MECHANISMS IN DIABETIC EMBRYOPATHY
    CLAUDIA T KAPPEN; Fiscal Year: 2010
    ..These experiments will generate new and comprehensive insights into the function of pancreatic transcription factors and their pathogenic potential in metabolic disease and fetal development. ..
  9. PATHOLOGY OF ENDOTHELIAL NEOVASCULARIZATION
    Joseph Madri; Fiscal Year: 2008
    ..abstract_text> ..
  10. Signaling Dynamics of Leukocyte-Tumor Cell Interactions
    HOWARD PETTY; Fiscal Year: 2008
    ..These new insights are likely to lead to advances in immunotherapy of cancer. ..
  11. Coordination of fetal growth by nutrient availability
    NICHOLAS ILLSLEY; Fiscal Year: 2008
    ..abstract_text> ..
  12. Genetic dissection of skeletal patterning
    Claudia Kappen; Fiscal Year: 2006
    ..The identification of modifier loci that act on skeletal patterning will reveal new molecular mechanisms in skeletal development and has important implications for the evolution of vertebrate body plans. ..
  13. Proteinase Modulation Diring T-Cell Endothelial Adhesion
    Joseph A Madri; Fiscal Year: 2010
    ..Specifically we will use WT, CD31 KO, MMP-2 KO, MMP-9 KO, MMP-14 and -/- and CD44 KO mice, and bone marrow chimeric mice generated from these mice. ..
  14. OMEGA-3 SUPPLMENTATION DECREASES INFLAMMATION AND FETAL OBESITY IN PREGNANCY
    Sylvie Hauguel De Mouzon; Fiscal Year: 2010
    ..Pretiminary data witt also be obtained on fetat body composition in order to later address the prevention of the long term adverse effects (devetopmental programming) of maternal obesity in the developing fetus. ..
  15. WATCHING TARGET CELL OXIDATION AND CYTOLYSIS
    HOWARD PETTY; Fiscal Year: 2001
    ..Our studies will determine the nature and mechanisms of inter-receptor interactions, which may lead to the development of new anti-inflammatory agents. ..
  16. Mechanisms Regulating Neutrophil Activation in Pregnancy
    HOWARD PETTY; Fiscal Year: 2005
    ..abstract_text> ..
  17. DEVELOPMENT OF A HUMAN PLACENTA VILLOUS MICROPERFUSION
    NICHOLAS ILLSLEY; Fiscal Year: 2002
    ..This model will provide the basis for new investigations in placental transport, metabolism, and signaling and structural biology. ..
  18. Placenta Association of the Americas satellite meeting
    NICHOLAS ILLSLEY; Fiscal Year: 2002
    ..These meetings have been very successful previously and continue to grow in size; we had approximately 200 attendees last year and expect to exceed that at the next meeting. ..
  19. FUNCTION OF B-DEFENSINS IN COMMON ORAL INFECTIONS
    Janet Guthmiller; Fiscal Year: 2002
    ....
  20. PLACENTAL GLUCOSE TRANSPORT IN DIABETIC PREGNANCIES
    NICHOLAS ILLSLEY; Fiscal Year: 2002
    ..The information obtained from these experimental approaches will significantly advance our understanding of the fetal response to maternal diabetes and the factors generating adverse perinatal consequences. ..
  21. FOLATE AND HOX GENES IN CRANIOFACIAL DEVELOPMENT
    Claudia Kappen; Fiscal Year: 2003
    ..Knowledge about the interactions of genes with environmental factors will be important for designing therapeutic strategies and preventive measures against craniofacial defects. ..
  22. CENTER FOR STUDY OF GROWTH REGULATION IN HUMAN PREGNANCY
    Patrick Catalano; Fiscal Year: 2004
    ..abstract_text> ..
  23. Mentored Patient-Oriented Research Career Development Aw
    Edmund Funai; Fiscal Year: 2004
    ....
  24. Genome-wide discovery of beta cell gene control elements
    Claudia Kappen; Fiscal Year: 2004
    ..Together, our studies will show how speck gene expression is achieved in beta cells and provide a framework to integrate gene transcription and beta cell biology. ..
  25. Placenta Association of the Americas Conference Grant
    NICHOLAS ILLSLEY; Fiscal Year: 2007
    ..Additional support is being sought from foundations and private corporations. ..
  26. Nutrition, Early Development and Glucose Metabolism
    Patricia Vuguin; Fiscal Year: 2007
    ..abstract_text> ..
  27. Genital Ulcer Disease and HIV Transmission
    Jeanne Sheffield; Fiscal Year: 2005
    ..The pursuit of these aims will further elucidate the cellular and molecular bases of the interrelationship between GUD and HIV-1 transmission, particularly in women. ..
  28. Reproductive Health Intervention for Teen Girls with DM
    Denise Charron Prochownik; Fiscal Year: 2009
    ..Thus setting new standards of practice, focusing on empowering teens with DM to make informed choices, and potentially improving their reproductive health and the health of their future children. ..
  29. CONSTRUCTION OF RESEARCH ANIMAL FACILITY
    Donald Wilson; Fiscal Year: 2002
    ..The proposed project, which will be co-financed by contributions from the State of Maryland, therefore, considered instrumental for sustaining the stature of the MPRC in schizophrenia research. ..
  30. GENERAL CLINICAL RESEARCH CENTER
    E Reece; Fiscal Year: 2009
    ..During the upcoming grant period, we anticipate the planning and funding of the UM Clinical and Translational Science Center. ..
  31. The Role of Inflammation and Parity on GDM and Type 2 DM
    Wanda Nicholson; Fiscal Year: 2008
    ..This award will give Dr. Nicholson the dedicated time and experience she needs to develop into an independent clinical investigator [unreadable] [unreadable]..
  32. GENERAL CLINICAL RESEARCH CENTER
    AUBREY MD HOUGH; Fiscal Year: 2006
    ..In this second funding cycle, the UAMS GCRC will continue expanding campus-wide clinical investigation. Support from all three sister institutions will continue to ensure GCRC success. ..
  33. Cancer Center Renovation Grant
    Donald Wilson; Fiscal Year: 2004
    ....
  34. Human Subjects Research Electronic Tracking System
    Donald Wilson; Fiscal Year: 2003
    ..WVU has a different organizational structure, a different information technology network, and different human subjects research emphasis from the University of Maryland School of Medicine. ..
  35. EXTRAMURAL RESEARCH FACILITIES IMPROVEMENT PROVEMENT
    Donald Wilson; Fiscal Year: 2003
    ....
  36. The Effectiveness of Treatment for Adult Periodontitis
    Philippe Hujoel; Fiscal Year: 2006
    ..This information can help determine in what area of periodontal research definitive clinical trials may offer the greatest contribution. ..
  37. Mentored Patient Oriented Career Development Award
    James Nicholson; Fiscal Year: 2006
    ..abstract_text> ..
  38. Brown University BIRCWH Career Development Program
    DONALD COUSTAN; Fiscal Year: 2006
    ..This interdisciplinary and cross-institutional program will provide a new cadre of academic investigators who will further the scientific database and improved the health status of women. ..