placenta diseases

Summary

Summary: Pathological processes or abnormal functions of the PLACENTA.

Top Publications

  1. pmc Impact of malaria during pregnancy on low birth weight in sub-Saharan Africa
    Helen L Guyatt
    Kenya Medical Research Institute Wellcome Trust Collaborative Programme, P O Box 43640, Nairobi, Kenya
    Clin Microbiol Rev 17:760-9, table of contents. 2004
  2. ncbi Pregnancy outcomes in women with or without placental malaria infection
    S N Kassam
    School of Biomedical Sciences, University of Bristol, Bristol, UK
    Int J Gynaecol Obstet 93:225-32. 2006
  3. ncbi Malaria in pregnancy: pathogenesis and immunity
    Stephen J Rogerson
    Department of Medicine, University of Melbourne, Parkville, Victoria, Australia
    Lancet Infect Dis 7:105-17. 2007
  4. ncbi The sick placenta-the role of malaria
    B J Brabin
    Child and Reproductive Health Group, Liverpool School of Tropical Medicine, UK
    Placenta 25:359-78. 2004
  5. ncbi Placental malaria increases malaria risk in the first 30 months of life
    Norbert G Schwarz
    Medical Research Unit, Albert Schweitzer Hospital, Lambarene, Gabon, South Africa
    Clin Infect Dis 47:1017-25. 2008
  6. ncbi Placental inflammation
    Raymond W Redline
    Case Western Reserve University and Department of Pathology, University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44122, USA
    Semin Neonatol 9:265-74. 2004
  7. ncbi Syncytial knots, sprouts, apoptosis, and trophoblast deportation from the human placenta
    Graham J Burton
    Department of Physiology, Centre for Trophoblast Research, University of Cambridge, UK
    Taiwan J Obstet Gynecol 48:28-37. 2009
  8. pmc The "Great Obstetrical Syndromes" are associated with disorders of deep placentation
    Ivo Brosens
    Leuven Institute for Fertility and Embryology, Leuven, Belgium
    Am J Obstet Gynecol 204:193-201. 2011
  9. ncbi Correlates of placental infection with cytomegalovirus, parvovirus B19 or human herpes virus 7
    S S W Chow
    Department of Microbiology, Virology Division, SEALS, Prince of Wales Hospital, Randwick, New South Wales, Australia
    J Med Virol 78:747-56. 2006
  10. ncbi Global genetic diversity and evolution of var genes associated with placental and severe childhood malaria
    Adama R Trimnell
    Seattle Biomedical Research Institute, Seattle, WA, USA
    Mol Biochem Parasitol 148:169-80. 2006

Research Grants

  1. Plasma Membrane Repair Mechanisms in Placental Trophoblasts
    JOHN MITCHELL ROBINSON; Fiscal Year: 2013
  2. Epidemiologic Study of Placental Abruption
    Cande Ananth; Fiscal Year: 2006
  3. Tobacco Industry Tactics Aimed at Native Americans
    Laura Beebe; Fiscal Year: 2006
  4. Prenatal Risk Factors for Neuropsychiatric Disease
    Carolyn Salafia; Fiscal Year: 2007
  5. Transgenic Plant-Derived CMV Glycoprotein B Vaccine
    Mark Schleiss; Fiscal Year: 2007
  6. Novel Strategy for Animal Model Testing of HCMV Vaccines
    Mark Schleiss; Fiscal Year: 2007
  7. EPIDEMIOLOGY OF CMV
    Stuart Adler; Fiscal Year: 2007
  8. IMMUNE PROTECTION AGAINST MNU-INDUCTED DIGITAL DEFECTS
    MARY PRATER; Fiscal Year: 2006
  9. 10th International CMV Workshop
    Stuart Adler; Fiscal Year: 2005
  10. DELIVERY OF ANTIOXIDANT ENZYMES & GENES TO NEONATAL LUNG
    Jonathan Davis; Fiscal Year: 2004

Detail Information

Publications195 found, 100 shown here

  1. pmc Impact of malaria during pregnancy on low birth weight in sub-Saharan Africa
    Helen L Guyatt
    Kenya Medical Research Institute Wellcome Trust Collaborative Programme, P O Box 43640, Nairobi, Kenya
    Clin Microbiol Rev 17:760-9, table of contents. 2004
    ..These estimates imply that around 100,000 infant deaths each year could be due to LBW caused by malaria during pregnancy in areas of malaria endemicity in Africa...
  2. ncbi Pregnancy outcomes in women with or without placental malaria infection
    S N Kassam
    School of Biomedical Sciences, University of Bristol, Bristol, UK
    Int J Gynaecol Obstet 93:225-32. 2006
    ..To assess delivery outcomes in women with placental malaria who presented at public hospitals in Kisumu, a holoendemic region in western Kenya...
  3. ncbi Malaria in pregnancy: pathogenesis and immunity
    Stephen J Rogerson
    Department of Medicine, University of Melbourne, Parkville, Victoria, Australia
    Lancet Infect Dis 7:105-17. 2007
    ....
  4. ncbi The sick placenta-the role of malaria
    B J Brabin
    Child and Reproductive Health Group, Liverpool School of Tropical Medicine, UK
    Placenta 25:359-78. 2004
    ..These statistics and our limited understanding of its pathogenesis suggest the research priorities on this subject...
  5. ncbi Placental malaria increases malaria risk in the first 30 months of life
    Norbert G Schwarz
    Medical Research Unit, Albert Schweitzer Hospital, Lambarene, Gabon, South Africa
    Clin Infect Dis 47:1017-25. 2008
    ..An additional consequence may be increased risk of malaria in early life, although the epidemiological evidence of this consequence is limited...
  6. ncbi Placental inflammation
    Raymond W Redline
    Case Western Reserve University and Department of Pathology, University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44122, USA
    Semin Neonatol 9:265-74. 2004
    ..All of these factors combine to produce specific patterns of placental pathology that can be used to guide treatment, predict complications and explain adverse outcome...
  7. ncbi Syncytial knots, sprouts, apoptosis, and trophoblast deportation from the human placenta
    Graham J Burton
    Department of Physiology, Centre for Trophoblast Research, University of Cambridge, UK
    Taiwan J Obstet Gynecol 48:28-37. 2009
    ..We recognize that apoptotic changes can occur in pathologic pregnancies, but consider the deportation of trophoblast that has been linked to preeclampsia to be most likely of necrotic origin following ischemic injury...
  8. pmc The "Great Obstetrical Syndromes" are associated with disorders of deep placentation
    Ivo Brosens
    Leuven Institute for Fertility and Embryology, Leuven, Belgium
    Am J Obstet Gynecol 204:193-201. 2011
    ....
  9. ncbi Correlates of placental infection with cytomegalovirus, parvovirus B19 or human herpes virus 7
    S S W Chow
    Department of Microbiology, Virology Division, SEALS, Prince of Wales Hospital, Randwick, New South Wales, Australia
    J Med Virol 78:747-56. 2006
    ..The major pathogen detected in all cases of placental infection associated with fetal death was human CMV...
  10. ncbi Global genetic diversity and evolution of var genes associated with placental and severe childhood malaria
    Adama R Trimnell
    Seattle Biomedical Research Institute, Seattle, WA, USA
    Mol Biochem Parasitol 148:169-80. 2006
    ..These studies aid our understanding of the evolutionary mechanisms that shape var diversity and will be important to the development of vaccines against pregnancy associated malaria and severe malaria...
  11. ncbi Of mice and women: rodent models of placental malaria
    Lars Hviid
    Centre for Medical Parasitology at Department for International Health, Immunology, and Microbiology ISIM, University of Copenhagen and at Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Trends Parasitol 26:412-9. 2010
    ..However, many features of murine and human PM are similar, including involvement of VSAs analogous to PfEMP1. It thus appears that rodent model studies can further the understanding of VSA-dependent malaria pathogenesis and immunity...
  12. pmc ABO phenotypes and malaria related outcomes in mothers and babies in The Gambia: a role for histo-blood groups in placental malaria?
    Maria Paz Loscertales
    Child and Reproductive Health Group, Liverpool School of Tropical Medicine, Liverpool, UK
    Malar J 5:72. 2006
    ..This study analyses the association between ABO blood group phenotypes in relation to placental malaria pathology...
  13. ncbi A new, clinically oriented, unifying and simple placental classification system
    G Turowski
    Department of Pathology, Oslo University Hospital OUS, Oslo, Norway
    Placenta 33:1026-35. 2012
    ..At present there is no internationally accepted, clinically easy understandable, comprehensive morphological placental classification. This hampers international benchmarking and comparisons, and clinical research...
  14. pmc Placental-related diseases of pregnancy: Involvement of oxidative stress and implications in human evolution
    Eric Jauniaux
    Academic Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School, London, UK
    Hum Reprod Update 12:747-55. 2006
    ..This would impair the placentation process leading to chronic oxidative stress in the placenta and finally to diffuse maternal endothelial cell dysfunction...
  15. ncbi Acquisition and decay of antibodies to pregnancy-associated variant antigens on the surface of Plasmodium falciparum-infected erythrocytes that protect against placental parasitemia
    T Staalsoe
    Centre for Medical Parasitology, Copenhagen University Hospital Rigshospitalet and Institute for Medical Microbiology and Immunology, University of Copenhagen, 2200 Copenhagen N, Denmark
    J Infect Dis 184:618-26. 2001
    ..Data suggest that VSA(CSA) is a target for vaccination against PAM...
  16. ncbi [Do calcification of placenta reveal only maternal cigarette smoking?]
    Krzysztof Szymanowski
    Katedra i Klinika Zdrowia Matki i Dziecka, Uniwersytetu Medycznego im K Marcinkowskiego w Poznaniu
    Przegl Lek 64:879-81. 2007
    ..Cigarette smoking should not be considered as exclusive factor leading to formation deposits of calcium in placenta. The consumption of vitamin supplements probably also involve calcification of placenta tissue...
  17. ncbi Exploring the relationship between preterm placental calcification and adverse maternal and fetal outcome
    K H Chen
    Department of Obstetrics and Gynecology, Buddhist Tzu Chi General Hospital, Taipei Branch, Taipei, Taiwan
    Ultrasound Obstet Gynecol 37:328-34. 2011
    ..To explore the relationship between preterm placental calcification and adverse pregnancy outcome, including maternal and fetal outcomes...
  18. ncbi Fibrinoid and trophoblastic necrosis with massive chronic intervillositis: an extreme variant of villitis of unknown etiology
    C Labarrere
    Department of Pathology, Hospital Italiano, Buenos Aires, Argentina
    Am J Reprod Immunol Microbiol 15:85-91. 1987
    ..A maternal immunological aggression toward fetal tissues is proposed as pathophysiological mechanism, although a nondetermined placental infection cannot be excluded...
  19. ncbi Alcohol injection for the intrauterine treatment of chorioangioma in a pregnancy with transfusion resistant fetal anemia: a case report
    Ozgur Deren
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Hacettepe University, Ankara, Turkey
    Fetal Diagn Ther 22:203-5. 2007
    ..Successful intratumoral injection of absolute ethyl alcohol relieved hydrops fetalis and polyhydramnios. Unfortunately, pregnancy ended at 28th week and a 1,330 g fetus was delivered...
  20. ncbi Prenatal management of placental chorioangioma: value of the middle cerebral artery peak systolic velocity
    D Escribano
    Fetal Pathophysiology and Ultrasound Unit, Department of Obstetrics and Gynecology, Hospital Universitario 12 de Octubre, Madrid, Spain
    Fetal Diagn Ther 21:489-93. 2006
    ..Spontaneous thrombosis of the main supplying blood vessel of the chorioangioma was detected at 33 weeks. The child was delivered at 39 weeks of pregnancy in normal clinical condition...
  21. ncbi The pathogenesis of villitis of unknown etiology: analysis with a new conjoint immunohistochemistry-in situ hybridization procedure to identify specific maternal and fetal cells
    David Myerson
    Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA
    Pediatr Dev Pathol 9:257-65. 2006
    ..Our findings indicate that invasion of fetal villi by maternal T cells is associated with focal destruction of the syncytiotrophoblast, clarifying how placental immuno-defensive mechanisms may be contravened...
  22. ncbi Histologic correlates of viral and bacterial infection of the placenta associated with severe morbidity and mortality in the newborn
    Anjali Satosar
    Department of Pathology, Ohio State University Medical Center, Columbus, OH 43210, USA
    Hum Pathol 35:536-45. 2004
    ..025). These data show that infection of the villi is highly associated with neonatal morbidity and mortality and that the histologic findings are, in most cases, nonspecific for infection...
  23. pmc Hypertension and maternal-fetal conflict during placental malaria
    Atis Muehlenbachs
    MOMS Project, Seattle Biomedical Research Institute, Seattle, Washington, United States of America
    PLoS Med 3:e446. 2006
    ..Malaria and hypertension are major causes of maternal mortality in tropical countries, especially during first pregnancies, but evidence for a relationship between these syndromes is contradictory...
  24. ncbi Expressional and epigenetic alterations of placental serine protease inhibitors: SERPINA3 is a potential marker of preeclampsia
    Sonia T Chelbi
    Equipe 21, Génomique et Epigénetique des Pathologies Placentaires, Unité INSERM 567 UMR Centre National de la Recherche Scientifique 8104, Université Paris V IFR Alfred Jost, Faculte de Medecine, Cochin Port Royal, Paris, France
    Hypertension 49:76-83. 2007
    ..Our results provide one of the first observations of a specific epigenetic alteration in human placental diseases and provide new potential markers for an early diagnosis...
  25. ncbi Study of placenta of children born with congenital malformations
    Claude Stoll
    Service de Genetique Medicale, Centre Hospitalo Universitaire, Strasbourg, France
    Ann Genet 46:1-5. 2003
    ..The human placenta discounts a principal functional part, the maternal blood in the intervillous space. Congenital malformations may interact with this function...
  26. ncbi A variant in the gene FUT9 is associated with susceptibility to placental malaria infection
    Martin Sikora
    Institute of Evolutionary Biology UPF CSIC, CEXS UPF PRBB, Barcelona, Catalonia, Spain
    Hum Mol Genet 18:3136-44. 2009
    ..These results therefore suggest an involvement of this antigen in the pathogenesis of placental malaria infection...
  27. ncbi Inflammatory responses in the placenta and umbilical cord
    Raymond W Redline
    Case School of Medicine, Department of Pathology, University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    Semin Fetal Neonatal Med 11:296-301. 2006
    ..This review summarises the relationships between aetiology, intensity, duration, characteristics and site of histological placental inflammation and suggests how these data may help to better understand the antenatal environment...
  28. pmc ABO blood group and the risk of placental malaria in sub-Saharan Africa
    Ayola A Adegnika
    Medical Research Unit, Albert Schweitzer Hospital, Lambarene, Gabon
    Malar J 10:101. 2011
    ..Here, the association between ABO blood group and incidence of placental malaria was assessed in order to determine the possible influence of the former on the latter...
  29. pmc Impact of placental Plasmodium falciparum malaria on pregnancy and perinatal outcome in sub-Saharan Africa: part III: placental malaria, maternal health, and public health
    Chigozie J Uneke
    Department of Medical Microbiology Parasitology, Ebonyi State University, Nigeria
    Yale J Biol Med 81:1-7. 2008
    ..The effects of placental malaria on maternal health can better be understood when considered in relation with various maternal parameters, including maternal age, parity, peripheral malaria infection, anemia, and HIV infection...
  30. ncbi The placenta and malaria
    A Matteelli
    Clinic of Infectious and Tropical Diseases, University of Brescia, Italy
    Ann Trop Med Parasitol 91:803-10. 1997
    ..A deeper understanding of the mechanisms involved in this process is of key importance in the design of protective interventions which are effective and acceptable during the gestation period...
  31. ncbi Alcoholization: the choice of intrauterine treatment for chorioangioma
    Chanane Wanapirak
    Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Thailand
    J Obstet Gynaecol Res 28:71-5. 2002
    ..To our knowledge, this is the first report using alcoholization for the treatment of hydrops fetalis secondary to chorioangioma...
  32. pmc ABO blood group system and placental malaria in an area of unstable malaria transmission in eastern Sudan
    Ishag Adam
    Department of Obstetrics and Gynecology, Faculty of Medicine University of Khartoum, Sudan
    Malar J 6:110. 2007
    ..Understanding the pathogenesis of malaria in pregnancy and its consequences for both the mother and the baby is fundamental for improving malaria control in pregnant women...
  33. ncbi The immunology and pathogenesis of malaria during pregnancy
    J G Beeson
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Curr Top Microbiol Immunol 297:187-227. 2005
    ..Emerging knowledge of the pathogenesis and immunology of malaria in pregnancy will increasingly lead to new opportunities for the development of therapeutic and preventive interventions and new tools for diagnosis and monitoring...
  34. ncbi Link between the early calcium deposition in placenta and nanobacterial-like infection
    R M Agababov
    Medical Academy, Donetsk, Ukraine
    J Biosci 32:1163-8. 2007
    ..We hypothesize that the increased placental calcification might be caused, at least in part, by nanobacterial infection...
  35. ncbi Gene expression of nitric oxide synthase by human umbilical vein endothelial cells: the effect of fetal plasma from pregnancy with umbilical placental vascular disease
    Xin Wang
    Department of Obstetrics and Gynaecology, University of Sydney at Westmead Hospital, New South Wales, Australia
    BJOG 110:53-8. 2003
    ..To determine whether endothelial cell injury would be produced by factor(s) released into the fetal circulation, manifested by altered messenger RNA expression of nitric oxide synthase...
  36. pmc ABO blood group phenotypes influence parity specific immunity to Plasmodium falciparum malaria in Malawian women
    Edward Senga
    Department of Biochemistry, University of Malawi College of Medicine, Blantyre, Malawi
    Malar J 6:102. 2007
    ..This study analyses the association between ABO blood group phenotypes in relation to placental malaria pathology and birth outcomes in southern Malawi, an area with perennial malaria transmission...
  37. ncbi Placental mesenchymal dysplasia is associated with high rates of intrauterine growth restriction and fetal demise: A report of 11 new cases and a review of the literature
    Truc Pham
    Department of Pathology, University of California, San Diego, CA 92103 8720, USA
    Am J Clin Pathol 126:67-78. 2006
    ..Thus, PMD is associated with high IUGR and IUFD/neonatal death rates and disproportionally affects females. The cause and pathogenesis are yet unknown. The current understanding and hypotheses involving PMD are discussed...
  38. ncbi Pseudo-partial moles: placental stem vessel hydrops and the association with Beckwith-Wiedemann syndrome and complete moles
    F J Paradinas
    Department of Histopathology, Imperial College School of Medicine at Charing Cross Hospital, London, UK
    Histopathology 39:447-54. 2001
    ....
  39. ncbi Placental mesenchymal dysplasia
    Julie Lokan
    Pathology 34:375-8. 2002
  40. ncbi Maternal vascular underperfusion: nosology and reproducibility of placental reaction patterns
    Raymond W Redline
    Department of Pathology, University Hospitals of Cleveland and Case Western Reserve University, 1100 Euclid Avenue, 44106, USA
    Pediatr Dev Pathol 7:237-49. 2004
    ..68). Adoption of this clearly defined, clinically relevant, and pathologically reproducible terminology could enhance clinicopathologic correlation and provide a more objective framework for future clinical research...
  41. ncbi How to study placental vascular development?
    F Herr
    Department of Obstetrics and Gynecology, University of Greifswald, Greifswald, Germany
    Theriogenology 73:817-27. 2010
    ..This report reviews major aspects of vascular development in the placenta and describes the establishment of a three-dimensional in vitro model of human placental vascular development...
  42. pmc Detection and clinical manifestation of placental malaria in southern Ghana
    Frank P Mockenhaupt
    Institute of Tropical Medicine and International Health, Charite University Medicine, Berlin, Germany
    Malar J 5:119. 2006
    ..Plasmodium falciparum can be detected by microscopy, histidine-rich-protein-2 (HRP2) capture test or PCR but the respective clinical relevance of the thereby diagnosed infections in pregnant women is not well established...
  43. ncbi New aspects in the pathophysiology of preeclampsia
    John M Davison
    Franz Volhard Clinic, Wiltberg Strasse 50, 13125 Berlin, Germany
    J Am Soc Nephrol 15:2440-8. 2004
    ..Preeclamptic women also produce novel autoantibodies that may serve to activate angiotensin receptors. These new observations raise the possibility that the treatment of preeclamptic women will soon be improved...
  44. pmc Plasmodium falciparum infection of the placenta impacts on the T helper type 1 (Th1)/Th2 balance of neonatal T cells through CD4(+)CD25(+) forkhead box P3(+) regulatory T cells and interleukin-10
    C Bisseye
    Medical Research Council Laboratories, Banjul, The Gambia
    Clin Exp Immunol 158:287-93. 2009
    ..These results suggest that the impact of P. falciparum infection on Th1 differentiation of neonatal T cells can be ascribed to regulatory T cells through production of IL-10...
  45. pmc Androgenetic/biparental mosaicism causes placental mesenchymal dysplasia
    K A Kaiser-Rogers
    J Med Genet 43:187-92. 2006
    ..Intrauterine growth restriction is common, yet, paradoxically, many of the associated fetuses/newborns have been diagnosed with Beckwith-Wiedemann syndrome (BWS)...
  46. ncbi Reduced cord blood immune effector-cell responsiveness mediated by CD4+ cells induced in utero as a consequence of placental Plasmodium falciparum infection
    Kim Brustoski
    Department of Parasitology, Institute for Tropical Medicine, University of Tubingen, Germany
    J Infect Dis 193:146-54. 2006
    ..These data demonstrate that parasite Ag-specific CD4(+) regulatory cells are generated in utero as a consequence of placental P. falciparum infection...
  47. pmc Evaluation of the OptiMAL rapid antigen test and species-specific PCR to detect placental Plasmodium falciparum infection at delivery
    Limangeni Mankhambo
    College of Medicine, University of Malawi, Blantyre, Malawi
    J Clin Microbiol 40:155-8. 2002
    ..Neither OptiMAL nor PCR testing of peripheral blood is adequately sensitive to detect all placental malaria infection, but a positive result by OptiMAL testing identifies women with a high proportion of low-birth-weight babies...
  48. pmc Diagnosis of Plasmodium falciparum malaria at delivery: comparison of blood film preparation methods and of blood films with histology
    Stephen J Rogerson
    Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Blantyre, Malawi
    J Clin Microbiol 41:1370-4. 2003
    ..02). Placental histology is the most sensitive method for the diagnosis of malaria in pregnancy. Methods for preparation of placental films may affect the density, but not the prevalence, of P. falciparum infection detected...
  49. ncbi Comparison of intermittent preventive treatment with chemoprophylaxis for the prevention of malaria during pregnancy in Mali
    Kassoum Kayentao
    Malaria Research and Training Center, Department of Epidemiology and Parasitic Diseases, Faculty of Medicine and Dentistry, University of Bamako, Bamako, Mali
    J Infect Dis 191:109-16. 2005
    ..To our knowledge, there are no published trials evaluating IPT in West Africa...
  50. ncbi Role of nonimmune IgG bound to PfEMP1 in placental malaria
    K Flick
    Microbiology and Tumor Biology Center (MTC, Karolinska Institutet and Swedish Institute for Infectious Disease Control, Box 280, S-171 77 Stockholm, Sweden
    Science 293:2098-100. 2001
    ..Normal, nonimmune IgG that is bound to a duffy binding-like domain beta of the P. falciparum erythrocyte membrane protein 1 (PfEMP1) might at the IE surface act as a bridge to neonatal Fc receptors of the placenta...
  51. ncbi [Placental malaria and pregnancy outcome in a peri urban area in Senegal]
    C T N'Dao
    UR 010 Santé de la mère et de l enfant, Institut de Recherche pour le Développement IRD Faculté de Pharmacie, 4, avenue de l Observatoire, 75006 Paris
    Rev Epidemiol Sante Publique 54:149-56. 2006
    ..These observations suggest a possible link between malaria and maternal or fetal morbidity and mortality. In this study, we explore this link in a peri urban maternity in Senegal...
  52. pmc Maternal peripheral blood level of IL-10 as a marker for inflammatory placental malaria
    Edward R Kabyemela
    Mother Offspring Malaria Studies MOMS Project, Seattle Biomedical Research Institute, Seattle WA 98109, USA
    Malar J 7:26. 2008
    ..Diagnosis is difficult because PM is often asymptomatic, peripheral blood smear examination detects parasitemia as few as half of PM cases, and no peripheral markers have been validated for placental inflammation...
  53. ncbi Is malarial placental infection related to peripheral infection at any time of pregnancy?
    Gilles Cottrell
    Institut de Recherche pour le Developpement, UR 010 Santé de la mère et de l enfant en milieu tropical, Paris, France
    Am J Trop Med Hyg 73:1112-8. 2005
    ..9 [1.3; 6.3]; after 7 months: OR = 4.9 [2.7; 8.8]). Therefore, an early peripheral infection may persist throughout gestation, and placental infection is a good indicator of the women's parasitological status during pregnancy...
  54. ncbi High prevalence of placental malaria and low birth weight in Sahelian periurban area
    Demba Sarr
    Institut Pasteur de Dakar, Dakar, Senegal
    Am J Trop Med Hyg 75:171-7. 2006
    ..Severe anemia was also associated with chronic infection. Long-lasting infections are the most deleterious to mother and infant and are most likely associated with drug resistance of parasites...
  55. ncbi Genome-wide expression analysis of placental malaria reveals features of lymphoid neogenesis during chronic infection
    Atis Muehlenbachs
    Mother Offspring Malaria Study MOMS Project, Seattle Biomedical Research Institute, 307 Westlake Avenue North, Seattle, WA 98109, USA
    J Immunol 179:557-65. 2007
    ..We propose a model where the production of Ig during chronic malaria may enhance inflammation by attracting and activating macrophages that, in turn, recruit B cells to further produce Ig in the intervillous spaces...
  56. ncbi Effectiveness of intermittent preventive treatment with sulphadoxine-pyrimethamine for control of malaria in pregnancy in western Kenya: a hospital-based study
    A M van Eijk
    Kenya Medical Research Institute, Centre for Vector Biology and Control Research, Kisumu, Kenya
    Trop Med Int Health 9:351-60. 2004
    ....
  57. pmc Gravidity-dependent production of antibodies that inhibit binding of Plasmodium falciparum-infected erythrocytes to placental chondroitin sulfate proteoglycan during pregnancy
    R N Achur
    Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington, DC 20007, USA
    Infect Immun 69:7487-92. 2001
    ..The early onset of efficient antibody response in multigravidae and the delayed production to antibodies in primigravidae appear to account for the gravidity-dependent differential susceptibilities of pregnant women to placental malaria...
  58. ncbi Placental mesenchymal dysplasia
    Zahida Parveen
    University of Hawaii Pathology Residency Program, Honolulu, USA
    Arch Pathol Lab Med 131:131-7. 2007
    ..It may be associated with a completely normal fetus, a fetus with growth restriction, or a fetus with features of Beckwith-Wiedemann syndrome...
  59. pmc Expression and localization of estrogen receptor-alpha protein in normal and abnormal term placentae and stimulation of trophoblast differentiation by estradiol
    Antonin Bukovsky
    Laboratory for Development, Differentiation and Cancer, Department of Obstetrics and Gynecology, The University of Tennessee Graduate School of Medicine, Knoxville, Tennessee 37920, USA
    Reprod Biol Endocrinol 1:13. 2003
    ..This mechanism, however, may not operate in abnormal placentae, which show a lack of ER-alpha expression...
  60. ncbi Conjugated action of two species-specific invasion proteins for fetoplacental listeriosis
    Olivier Disson
    Institut Pasteur, Groupe Microorganismes et Barrières de l Hôte, Unité des Interactions Bactéries Cellules, F 75015 Paris, France
    Nature 455:1114-8. 2008
    ....
  61. ncbi In vivo acquisition of hemozoin by placental blood mononuclear cells suppresses PGE2, TNF-alpha, and IL-10
    Douglas J Perkins
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Biochem Biophys Res Commun 311:839-46. 2003
    ..Results presented here show that in vivo acquisition of high levels of hemozoin by IVBMC leads to decreased synthesis of PGE(2), IL-10, and TNF-alpha...
  62. pmc Diagnosis of placental malaria
    Frank P Mockenhaupt
    Institute of Tropical Medicine, Charite, Humboldt University, Berlin, Germany
    J Clin Microbiol 40:306-8. 2002
    ..In addition to the gross underestimation of placental malaria by peripheral blood film microscopy, submicroscopic infections were found to be a risk factor for maternal anemia...
  63. ncbi Prenatal embolisation of a large chorioangioma using enbucrilate
    Tze Kin Lau
    Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong
    BJOG 112:1002-4. 2005
  64. ncbi Ultrasound-guided interstitial laser therapy for the treatment of placental chorioangioma
    Amar Bhide
    Fetal Medicine Unit, Academic Department of Obstetrics and Gynaecology, St George s Hospital Medical School, London, United Kingdom
    Obstet Gynecol 102:1189-91. 2003
    ..Placental chorioangioma is a relatively rare malformation with potential to cause fetal hydrops and even death. We describe ultrasound-guided interstitial laser as a modality for treating chorioangiomas of the placenta...
  65. ncbi Coxiella burnetii associated placental lesions and infection level in parturient cows
    Mette S Hansen
    Department of Veterinary Disease Biology, University of Copenhagen, Frederiksberg C, Denmark
    Vet J 190:e135-9. 2011
    ..This may explain why bovine Q fever is usually not clinically apparent. Nevertheless, infected cattle will shed C. burnetii at calving and this can occur even in herds without BTM antibodies...
  66. pmc The C5b-9 membrane attack complex of complement activation localizes to villous trophoblast injury in vivo and modulates human trophoblast function in vitro
    R Rampersad
    Department of Obstetrics and Gynecology, Washington University, 4566 Scott Avenue, Saint Louis, MO 63110, USA
    Placenta 29:855-61. 2008
    ..Our findings demonstrate that MAC associates with fibrin deposits at sites of villous injury in vivo. Hypoxia also enhances MAC deposition in cultured trophoblasts and MAC alters trophoblast function in a phenotype specific manner...
  67. ncbi Villitis of known origin: varicella and toxoplasma
    K Benirschke
    University of California, University Medical Center, San Diego 92103 8321, USA
    Placenta 20:395-9. 1999
    ..The identification of the pathogens, varicella virus and toxoplasma, would easily have been overlooked in routine study of the placenta and were possible because of clinical suspicion...
  68. ncbi A fetal cyclooxygenase-2 gene polymorphism is associated with placental malperfusion
    Alexandros D Polydorides
    Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital, New York, New York, USA
    Int J Gynecol Pathol 26:284-90. 2007
    ..Thus, a fetal polymorphism in the COX-2 gene influences the occurrence of placental malperfusion and ischemia, which may be of sufficient severity to promote or allow the development of IUGR...
  69. ncbi Prenatal laser treatment of a placental chorioangioma
    E Quarello
    Department of Obstetrics and Gynecology, Universite Paris Ouest, Poissy, France
    Ultrasound Obstet Gynecol 25:299-301. 2005
    ..Laser coagulation of the feeding vessels seems to be an effective treatment for chorioangiomas when the blood supply is superficial and the feeding vessels are small in diameter...
  70. ncbi Haemozoin as a marker of placental parasitization
    Rose McGready
    Shoklo Malaria Research Unit, P O Box 46, Mae Sot 63110, Thailand
    Trans R Soc Trop Med Hyg 96:644-6. 2002
    ..Women with P. vivax infections during pregnancy do not have measurable levels of placental haemozoin suggesting that P. vivax-infected erythrocytes do not accumulate in the placenta as much as P. falciparum-infected ones...
  71. ncbi Management of a placental chorioangioma with endoscopic devascularization and intrauterine transfusions
    C Bermudez
    Ultrasound Obstet Gynecol 29:97-8. 2007
  72. ncbi Giant placental chorioangioma: natural history and pregnancy outcome
    C Zanardini
    Fetal Medicine Unit, Academic Department of Obstetrics and Gynaecology, St George s Hospital Medical School, London, UK
    Ultrasound Obstet Gynecol 35:332-6. 2010
    ..The aim of the study was to evaluate the natural history, intrauterine treatment and outcome of pregnancies complicated by giant placental chorioangioma...
  73. ncbi Perinatal outcome after prenatal diagnosis of placental chorioangioma
    Waldo Sepulveda
    Fetal Medicine Center, Department of Obstetrics and Gynecology, Clinica Las Condes, Santiago, Chile
    Obstet Gynecol 102:1028-33. 2003
    ..To review the prenatal complications, management, and perinatal outcome in pregnancies complicated by placental chorioangioma...
  74. ncbi Evaluation of a malaria rapid diagnostic test for assessing the burden of malaria during pregnancy
    Lauren M Singer
    Malaria Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Am J Trop Med Hyg 70:481-5. 2004
    ..1% by RDT. When the PCR was used as the gold standard, RDTs had a sensitivity of 89% and a specificity of 76%. The MAKROmed RDT was highly sensitive in the detection of placental malaria, but had lower than expected specificity...
  75. ncbi Placental mesenchymal dysplasia associated with hepatic mesenchymal hamartoma in the newborn
    Babu Francis
    Department of Neonatology, Fetal Medicine Unit, The Canberra Hospital, Woden, and Australian National University Medical School, Canberra, ACT, Australia
    Pediatr Dev Pathol 10:50-4. 2007
    ..This appears to be the 3rd histologically confirmed association of placental mesenchymal dysplasia with mesenchymal hamartoma of the liver in the English language literature...
  76. ncbi Clinical significance of pregnancies with circumvallate placenta
    Shunji Suzuki
    Department of Obstetrics and Gynecology, Japanese Red Cross Katsushika Maternity Hospital, Katsushika ku, Tokyo, Japan
    J Obstet Gynaecol Res 34:51-4. 2008
    ..This study examined the clinical significance of patients complicated by circumvallate placenta in comparison with patients with a normal placenta...
  77. ncbi Morphometric placental villous and vascular abnormalities in early- and late-onset pre-eclampsia with and without fetal growth restriction
    M Egbor
    Department of Surgical Research, NPIMR, Northwick Park Hospital, Harrow, UK
    BJOG 113:580-9. 2006
    ..To evaluate placental morphology in pregnancies complicated by early- and late-onset pre-eclampsia (PET) with and without fetal growth restriction (FGR) using stereological techniques...
  78. ncbi Placental enlargement in women with primary maternal cytomegalovirus infection is associated with fetal and neonatal disease
    Renato La Torre
    Department of Gynecological Sciences, Perinatology, and Child Health, La Sapienza University, Rome, Italy
    Clin Infect Dis 43:994-1000. 2006
    ..Serological testing for primary maternal cytomegalovirus (CMV) infection during pregnancy is not routine, but ultrasound studies are routine. Therefore, we evaluated placental thickening in women with primary CMV infection during pregnancy...
  79. ncbi Diffuse placental chorioangiomatosis causing multiple fetal cerebral embolism: a case report
    Alessandro Ghidini
    Perinatalogy Services, Department of Obstetrics and Gynecology, Inova Alexandria Hospital, 4320 Seminary Road, Alexandria, VA 22304, USA
    J Reprod Med 51:321-4. 2006
    ..The clinical significance of small hemangiomas is less known...
  80. ncbi The placenta as witness
    Rebecca N Baergen
    New York Presbyterian Hospital, Weill Cornell Medical Center, Department of Pathology, Starr 1002, 520 East 70th Street, New York, NY 10021, USA
    Clin Perinatol 34:393-407. 2007
    ..Markedly depleted reserves will render the infant susceptible to other, sometimes more acute, events and thus are also associated with significant injury or even death...
  81. ncbi Diffuse multifocal chorangiomatosis of the placenta with multiple intestinal stenosis of the fetus: combination of rare causes for nonimmune hydrops fetalis
    Anita Chopra
    Department of Pathology, All India Institute of Medical Sciences, New Delhi
    Indian J Pathol Microbiol 49:600-2. 2006
    ..Chorangiomatosis is a rare and under reported condition which can cause prematurity, intrauterine growth retardation, pre-eclampsia and rarely hydrops fetalis...
  82. ncbi The role of second trimester ultrasound in the diagnosis of placental hypoechoic lesions leading to poor pregnancy outcome
    Alexander Kofinas
    Department of Obstetrics and Gynecology, New York Methodist Hospital, New York, USA
    J Matern Fetal Neonatal Med 20:859-66. 2007
    ..The purpose of the study was to quantify placental hypoechoic areas without blood flow by means of second trimester high-resolution ultrasound with power color Doppler and to evaluate its relationship to pregnancy outcome...
  83. ncbi Transrectal ultrasonography and plasma progestin profiles identifies feto-placental compromise in mares with experimentally induced placentitis
    Steffani Morris
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Gainesville, FL 32611 0910, USA
    Theriogenology 67:681-91. 2007
    ..However, three inoculated mares exhibited minimal clinical signs and likely would not be examined in a clinical setting. These tests were diagnostic for identifying feto-placental compromise in the mare...
  84. ncbi Maternal asthma and placental morphometry: effects of severity, treatment and fetal sex
    T M Mayhew
    Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, E Floor, Queen s Medical Centre, University of Nottingham, Nottingham, UK
    Placenta 29:366-73. 2008
    ..The findings suggest that the morphometric differences in fetoplacental vascularity are likely to be due to the effects of asthma and use of inhaled GCs rather than the effects of maternal or fetal hypoxic stress...
  85. ncbi Fetal cardiac output, distribution to the placenta and impact of placental compromise
    T Kiserud
    Department of Clinical Medicine, Section of Obstetrics and Gynaecology, University of Bergen, Bergen, Norway
    Ultrasound Obstet Gynecol 28:126-36. 2006
    ..Our aim was to determine the normal distribution of fetal cardiac output to the placenta during the second half of pregnancy, and to assess the changes imposed by growth restriction with various degrees of placental compromise...
  86. ncbi [Embryo and fetal pathology in routine diagnostics: what has changed and what needs to be changed]
    E Fulcheri
    DICMI, Sezione di Anatomia Patologica, Universita di Genova, Italia
    Pathologica 98:1-36. 2006
    ..Diagnostic criteria are thus optimized and specially aimed at solving "human reproduction pathology" issues...
  87. ncbi Clinical significance of placental examination in perinatal medicine
    Drucilla J Roberts
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Matern Fetal Neonatal Med 19:255-64. 2006
    ..This review will focus on the utility of the placental examination for fetal and maternal well-being. This review will be restricted to singleton births...
  88. pmc Decline of placental malaria in southern Ghana after the implementation of intermittent preventive treatment in pregnancy
    Lena Hommerich
    Institute of Tropical Medicine and International Health, Charite University Medicine, Berlin, Germany
    Malar J 6:144. 2007
    ..Intermittent preventive treatment in pregnancy with sulphadoxine-pyrimethamine (IPTp-SP) has been adopted as policy by many countries in sub-Saharan Africa. However, data on the post-implementation effectiveness of this measure are scarce...
  89. ncbi Severe transient cardiac failure caused by placental chorangiosis
    Thomas Schmitz
    Department of Neonatology, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Berlin, Germany
    Neonatology 91:271-4. 2007
    ..Chorangiomas are villous capillary tumors of the placenta with high impact on neonatal morbidity and mortality. Cardiac complications have occasionally been reported...
  90. ncbi Doppler velocimetry for predicting outcome of pregnancies with decreased fetal movements
    Przemyslaw Korszun
    Department of Perinatology and Gynecology, University School of Medical Sciences, Poznan, Poland
    Acta Obstet Gynecol Scand 81:926-30. 2002
    ..The aim of this study was to evaluate umbilical artery (UA) and uterine artery (Ut.A) Doppler velocimetry in a low-risk pregnancy group with decreased fetal movements...
  91. ncbi Placental vascular development and neonatal outcome
    T Yee Khong
    Department of Histopathology, Women s and Children s Hospital, North Adelaide SA 5006, Australia
    Semin Neonatol 9:255-63. 2004
    ..Fetal thrombotic vasculopathy, commonly associated with thrombophilia, may be a cause of neurological deficit in childhood...
  92. ncbi [Placental chorioangiomas diagnosed during the second trimester of pregnancy: four cases]
    N Mubiayi
    Clinique de gynécologie obstétrique et néonatologie, Hopital Jeanne de Flandre, CHRU de Lille
    J Gynecol Obstet Biol Reprod (Paris) 31:187-92. 2002
    ....
  93. ncbi [Clinical characteristics and pathologic study of placental chorioangioma]
    Xiao Hong He
    Women s Hospital, School of Medicine, Zhejiang University, Hangzhou 31000, China
    Zhonghua Fu Chan Ke Za Zhi 39:227-9. 2004
    ..To describe the clinical characteristics and gross picture of placental chorioangioma...
  94. ncbi The role of intraplacental vascular smooth muscle in the dynamic placenta: a conceptual framework for understanding uteroplacental disease
    N J Sebire
    Department of Histopathology, Great Ormond Street Hospital, London, UK
    Med Hypotheses 58:347-51. 2002
    ....
  95. ncbi [Epidemiology of vascular placental disease]
    Veronique Lejeune
    Service de Gynecologie Obstetrique, Hopital Saint Antoine, 184, rue du Faubourg Saint Antoine, 75012 Paris
    Ann Med Interne (Paris) 154:310-5. 2003
    ..Stillbirth, defined as fetal death between 24 weeks of gestation and delivery, occur in 1.5 per 1,000 deliveries, with a higher frequency in case of placental abruption, intrauterine growth restriction or preeclampsia...
  96. ncbi The placenta in hematogenous infections
    Achilea Lisboa Bittencourt
    Department of Pathology, Federal University of Bahia, Brazil
    Pediatr Pathol Mol Med 21:401-32. 2002
    ..This routine ensures that the placentas of asymptomatic newborns who might present early manifestations suggestive of infection would be submittedfor pathologic examination...
  97. ncbi Review of some causes of stillbirth
    R W Bendon
    Department of Pathology, Kosair Children's Hospital, P.O. Box 35070, Louisville, KY 40232-5070, USA
    Pediatr Dev Pathol 4:517-31. 2001
    ..For each mechanism, the autopsy can discover any of multiple etiologies. This paper reviews the etiologies and pathogeneses of fetal death from that perspective...
  98. ncbi Expression of IGR-IR and VEGF and trophoblastic proliferative activity in placentas from pregnancies complicated by IUGR
    Duygu Gurel
    Department of Pathology, School of Medicine, Dokuz Eylul University, Izmir, Turkey
    Pathol Res Pract 199:803-9. 2003
    ..In contrast, based on our findings, trophoblastic proliferation and VEGF expression are unlikely to be significant parameters in the pathogenesis of IUGR...
  99. ncbi Preventing pregnancy malaria. Simple vaccines that stop parasites lodging in the placenta may save thousands of lives
    Michael McCarthy
    Lancet 363:132-3. 2004
  100. ncbi Three-dimensional sonographic features of placental abnormalities
    Toshiyuki Hata
    Department of Perinatology and Gynecology, Kagawa Medical University, Kagawa, Japan
    Gynecol Obstet Invest 57:61-5. 2004
    ..To describe three-dimensional (3D) sonographic features of placental abnormalities in utero...
  101. ncbi Shortened fetal long bones: a possible in utero manifestation of placental function
    Yaron Zalel
    Department of Obstetrics and Gynecology, The Chaim Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Hashomer, Israel
    Prenat Diagn 22:553-7. 2002
    ..The combination of SFLB, SGA fetuses and placental abnormalities (sonographic, as well as histological) suggested a possible common pathway in the aetiology of this association...

Research Grants16

  1. Plasma Membrane Repair Mechanisms in Placental Trophoblasts
    JOHN MITCHELL ROBINSON; Fiscal Year: 2013
    ..By studying how these proteins contribute to placental function, we will gain further understanding of placental diseases that may affect the well being of the fetus and pregnant women. ..
  2. Epidemiologic Study of Placental Abruption
    Cande Ananth; Fiscal Year: 2006
    ..It will also add substantial new evidence for associations of several genetic thrombophilias and abruption risk. ..
  3. Tobacco Industry Tactics Aimed at Native Americans
    Laura Beebe; Fiscal Year: 2006
    ..The results of this research will assist tribal, community and state agencies in their efforts to develop culturally appropriate counter-marketing strategies and tobacco abuse prevention and control interventions. ..
  4. Prenatal Risk Factors for Neuropsychiatric Disease
    Carolyn Salafia; Fiscal Year: 2007
    ..My training objectives are directly related to my proposed research, which focuses on the evaluation of the intrauterine environment and how predispositions to ND/NP compromise arise in utero. ..
  5. Transgenic Plant-Derived CMV Glycoprotein B Vaccine
    Mark Schleiss; Fiscal Year: 2007
    ..These studies will advance the fields of plant and CMV vaccines. [unreadable] [unreadable] [unreadable]..
  6. Novel Strategy for Animal Model Testing of HCMV Vaccines
    Mark Schleiss; Fiscal Year: 2007
    ..These studies will represent the first efficacy test of a human CMV subunit vaccine in a small animal model of congenital CMV infection. [unreadable] [unreadable]..
  7. EPIDEMIOLOGY OF CMV
    Stuart Adler; Fiscal Year: 2007
    ..The results of this study will establish if immunization of mothers against CMV infection is possible. ..
  8. IMMUNE PROTECTION AGAINST MNU-INDUCTED DIGITAL DEFECTS
    MARY PRATER; Fiscal Year: 2006
    ..This research under the guidance of Drs. Steven Holladay and Eric Wong at Virginia Tech...
  9. 10th International CMV Workshop
    Stuart Adler; Fiscal Year: 2005
    ..The purpose is to keep everybody up to date and current about what's going on in all areas and stimulate new research projects and collaborations. We anticipate between 300 and 500 attendees. ..
  10. DELIVERY OF ANTIOXIDANT ENZYMES & GENES TO NEONATAL LUNG
    Jonathan Davis; Fiscal Year: 2004
    ..Aim 4 is to compare the effects of PFC-protein or adenoviral-associated AOE suspensions on normal or injured, preterm or term lamb lungs, using assays for levels and duration of transgene expression. ..
  11. IGG PLACENTAL TRANSPORT: ENDOTHELIAL CAVEOLAE
    John Robinson; Fiscal Year: 2004
    ..Our approaches to testing the predictions of this hypothesis incorporate methods of cell biology, immunology, biochemistry, ultrastructural analysis, and molecular biology. ..
  12. BEHAVIORAL INTERVENTION FOR CONGENITAL CMV DISEASE
    Stuart Adler; Fiscal Year: 2001
    ..The results of this trial will determine the effectiveness of behavioral intervention and the motivation necessary to adhere to recommendations and prevent child-to-mother transmission of CMV. ..
  13. MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS
    T O SHEA; Fiscal Year: 2005
    ..abstract_text> ..
  14. Prevention of Cytomegalovirus Infection
    Stuart Adler; Fiscal Year: 2007
    ..The results of this study will establish if prevention of CMV infections is possible. [unreadable] [unreadable]..
  15. VACCINES FOR PREVENTION OF EXPERIMENTAL CONGENITAL CMV
    Mark Schleiss; Fiscal Year: 2009
    ..We anticipate that these subunit vaccine studies in this small animal model will clarify which strategies may be of value for vaccination against congenital HCMV infection. ..