premature birth

Summary

Summary: CHILDBIRTH before 37 weeks of PREGNANCY (259 days from the first day of the mother's last menstrual period, or 245 days after FERTILIZATION).

Top Publications

  1. doi Epidemiology and causes of preterm birth
    Robert L Goldenberg
    Department of Obstetrics and Gynecology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Lancet 371:75-84. 2008
  2. doi National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications
    Hannah Blencowe
    London School of Hygiene and Tropical Medicine, London, UK
    Lancet 379:2162-72. 2012
  3. doi Long-term medical and social consequences of preterm birth
    Dag Moster
    Department of Public Health and Primary Health Care, University of Bergen, Norway
    N Engl J Med 359:262-73. 2008
  4. pmc The effect of preterm birth on thalamic and cortical development
    Gareth Ball
    Centre for Developing Brain, Imperial College London and MRC Clinical Sciences Centre, Hammersmith Hospital, London W12 0NN, UK
    Cereb Cortex 22:1016-24. 2012
  5. ncbi Progesterone and the risk of preterm birth among women with a short cervix
    Eduardo B Fonseca
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, United Kingdom
    N Engl J Med 357:462-9. 2007
  6. pmc Ambient air pollution and preterm birth: a time-series analysis
    Lyndsey A Darrow
    Rollins School of Public Health, Emory University, Atlanta, GA, USA
    Epidemiology 20:689-98. 2009
  7. pmc The worldwide incidence of preterm birth: a systematic review of maternal mortality and morbidity
    Stacy Beck
    Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, USA
    Bull World Health Organ 88:31-8. 2010
  8. pmc Preventing preterm births: analysis of trends and potential reductions with interventions in 39 countries with very high human development index
    Hannah H Chang
    Boston Consulting Group, Boston, MA, USA
    Lancet 381:223-34. 2013
  9. ncbi Systematic review of effects of low-moderate prenatal alcohol exposure on pregnancy outcome
    J Henderson
    National Perinatal Epidemiology Unit, University of Oxford, Old Road Campus, Oxford, UK
    BJOG 114:243-52. 2007
  10. ncbi The sick placenta-the role of malaria
    B J Brabin
    Child and Reproductive Health Group, Liverpool School of Tropical Medicine, UK
    Placenta 25:359-78. 2004

Detail Information

Publications419 found, 100 shown here

  1. doi Epidemiology and causes of preterm birth
    Robert L Goldenberg
    Department of Obstetrics and Gynecology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Lancet 371:75-84. 2008
    ..A short cervical length and a raised cervical-vaginal fetal fibronectin concentration are the strongest predictors of spontaneous preterm birth...
  2. doi National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications
    Hannah Blencowe
    London School of Hygiene and Tropical Medicine, London, UK
    Lancet 379:2162-72. 2012
    ..We report worldwide, regional, and national estimates of preterm birth rates for 184 countries in 2010 with time trends for selected countries, and provide a quantitative assessment of the uncertainty surrounding these estimates...
  3. doi Long-term medical and social consequences of preterm birth
    Dag Moster
    Department of Public Health and Primary Health Care, University of Bergen, Norway
    N Engl J Med 359:262-73. 2008
    ..Advances in perinatal care have increased the number of premature babies who survive. There are concerns, however, about the ability of these children to cope with the demands of adulthood...
  4. pmc The effect of preterm birth on thalamic and cortical development
    Gareth Ball
    Centre for Developing Brain, Imperial College London and MRC Clinical Sciences Centre, Hammersmith Hospital, London W12 0NN, UK
    Cereb Cortex 22:1016-24. 2012
    ..This suggests that preterm delivery disrupts specific aspects of cerebral development, such as the thalamocortical system...
  5. ncbi Progesterone and the risk of preterm birth among women with a short cervix
    Eduardo B Fonseca
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, United Kingdom
    N Engl J Med 357:462-9. 2007
    ..Asymptomatic women found at midgestation to have a short cervix are at greatly increased risk for spontaneous early preterm delivery, and it is unknown whether progesterone reduces this risk in such women...
  6. pmc Ambient air pollution and preterm birth: a time-series analysis
    Lyndsey A Darrow
    Rollins School of Public Health, Emory University, Atlanta, GA, USA
    Epidemiology 20:689-98. 2009
    ..An emerging body of evidence suggests that ambient levels of air pollution during pregnancy are associated with preterm birth...
  7. pmc The worldwide incidence of preterm birth: a systematic review of maternal mortality and morbidity
    Stacy Beck
    Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, USA
    Bull World Health Organ 88:31-8. 2010
    ..To analyse preterm birth rates worldwide to assess the incidence of this public health problem, map the regional distribution of preterm births and gain insight into existing assessment strategies...
  8. pmc Preventing preterm births: analysis of trends and potential reductions with interventions in 39 countries with very high human development index
    Hannah H Chang
    Boston Consulting Group, Boston, MA, USA
    Lancet 381:223-34. 2013
    ..This analysis is to inform a rate reduction target for Born Too Soon...
  9. ncbi Systematic review of effects of low-moderate prenatal alcohol exposure on pregnancy outcome
    J Henderson
    National Perinatal Epidemiology Unit, University of Oxford, Old Road Campus, Oxford, UK
    BJOG 114:243-52. 2007
    ..4 UK units or 83 g/week) compared with consumption of no alcohol on pregnancy outcome...
  10. ncbi The sick placenta-the role of malaria
    B J Brabin
    Child and Reproductive Health Group, Liverpool School of Tropical Medicine, UK
    Placenta 25:359-78. 2004
    ..These statistics and our limited understanding of its pathogenesis suggest the research priorities on this subject...
  11. doi Preventing preterm birth and neonatal mortality: exploring the epidemiology, causes, and interventions
    Lavone E Simmons
    Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195 6460, USA
    Semin Perinatol 34:408-15. 2010
    ....
  12. pmc The effects of socioeconomic status and indices of physical environment on reduced birth weight and preterm births in Eastern Massachusetts
    Ariana Zeka
    Department of Environmental Health, Harvard School of Public Health, Harvard University, Landmark Suite 415 West, Boston, MA 02115, USA
    Environ Health 7:60. 2008
    ..While use of spatial methods to estimate exposure to air pollution has increased the power to detect effects, questions have been raised about potential for confounding by social factors...
  13. doi 3.6 million neonatal deaths--what is progressing and what is not?
    Joy E Lawn
    Saving Newborn Lives Save the Children US, Cape Town, South Africa
    Semin Perinatol 34:371-86. 2010
    ..A critical step is improving the quantity, quality and use of data to select and implement the most effective interventions and strengthen existing programs, especially at district level...
  14. ncbi Preterm birth and multiple pregnancy in European countries participating in the PERISTAT project
    B Blondel
    INSERM, U149, Epidemiological Research Unit on Perinatal and Women s Health, Paris and Villejuif, France
    BJOG 113:528-35. 2006
    ..To compare rates of preterm birth among multiple births in European countries, to estimate their contribution to overall preterm birth rates and to explore factors which could explain differences between preterm birth rates...
  15. pmc Gray matter injury associated with periventricular leukomalacia in the premature infant
    Christopher R Pierson
    Department of Pathology, Children s Hospital Boston, Boston, MA, USA
    Acta Neuropathol 114:619-31. 2007
    ..Gray matter lesions occur in a third or more of PVL cases suggesting that white matter injury generally does not occur in isolation, and that the term "perinatal panencephalopathy" may better describe the scope of the neuropathology...
  16. ncbi Ambient air pollution and preterm birth in the environment and pregnancy outcomes study at the University of California, Los Angeles
    Beate Ritz
    Department of Epidemiology, School of Public Health, University of California, Los Angeles, CA 90095, USA
    Am J Epidemiol 166:1045-52. 2007
    ..These results confirm the importance of reducing exposure misclassification when evaluating the effect of traffic-related pollutants that vary spatially...
  17. pmc Mapping a new spontaneous preterm birth susceptibility gene, IGF1R, using linkage, haplotype sharing, and association analysis
    Ritva Haataja
    Department of Pediatrics, Institute of Clinical Medicine, University of Oulu, Oulu, Finland
    PLoS Genet 7:e1001293. 2011
    ..Our findings support the identification of the novel susceptibility gene IGF1R for predisposition by the fetal genome to being born preterm...
  18. pmc Intrauterine inflammation, insufficient to induce parturition, still evokes fetal and neonatal brain injury
    Michal A Elovitz
    Maternal and Child Health Research Program, Department of Obstetrics and Gynecology, Center for Research in Reproduction and Women s Health, University of Pennsylvania School of Medicine, 421 Curie Blvd, 1354 BRB 2 3, Philadelphia, PA 19104 6142, United States
    Int J Dev Neurosci 29:663-71. 2011
    ..Subclinical intrauterine inflammation can lead to fetal brain injury and is likely to be mechanistically associated with long term adverse outcomes for exposed offspring...
  19. doi Intrauterine inflammation and preterm delivery
    N Vrachnis
    Second Department of Obstetrics and Gynecology, Aretaieion Hospital, University of Athens Medical School, Athens, Greece
    Ann N Y Acad Sci 1205:118-22. 2010
    ..Although no current clinical strategy is aimed at adapting the maternofetal inflammatory response, immunomodulators may serve as a future intervention in preterm embryos...
  20. pmc Dose-response relationship between alcohol consumption before and during pregnancy and the risks of low birthweight, preterm birth and small for gestational age (SGA)-a systematic review and meta-analyses
    J Patra
    Centre for Addiction and Mental Health, Toronto, ON, Canada
    BJOG 118:1411-21. 2011
    ..Descriptions of the effects of moderate alcohol consumption during pregnancy on adverse pregnancy outcomes have been inconsistent...
  21. doi Inflammatory cytokines and spontaneous preterm birth in asymptomatic women: a systematic review
    Shu Qin Wei
    Department of Obstetrics and Gynecology, Sainte Justine Hospital, University of Montreal, Quebec, Canada
    Obstet Gynecol 116:393-401. 2010
    ..To estimate the association between inflammatory cytokines and the risk of spontaneous preterm birth in asymptomatic women...
  22. pmc Long-term neurodevelopmental outcomes after intrauterine and neonatal insults: a systematic review
    Michael K Mwaniki
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    Lancet 379:445-52. 2012
    ..We did a systematic review to estimate risks of long-term neurocognitive and other sequelae after intrauterine and neonatal insults, especially in low-income and middle-income countries...
  23. doi Effect of sustained inflation length on establishing functional residual capacity at birth in ventilated premature rabbits
    Arjan B Te Pas
    Neonatal Services, Royal Women s Hospital, Parkville, Victoria 3053, Australia
    Pediatr Res 66:295-300. 2009
    ..0 (4.1) s using 35 cm H2O peak inflation pressure. In these rabbits, 10- and 20-s SI increased the inspiratory volume and produced a greater FRC, and a 20-s SI uniformly aerated the lung before ventilation started...
  24. pmc Effects of gestational age at birth on health outcomes at 3 and 5 years of age: population based cohort study
    Elaine M Boyle
    Department of Health Sciences, University of Leicester, Leicester LE1 6TP, UK
    BMJ 344:e896. 2012
    ..To investigate the burden of later disease associated with moderate/late preterm (32-36 weeks) and early term (37-38 weeks) birth...
  25. pmc Association between local traffic-generated air pollution and preeclampsia and preterm delivery in the south coast air basin of California
    Jun Wu
    Program in Public Health, College of Health Sciences, University of California, Irvine, California 92697 7555, USA
    Environ Health Perspect 117:1773-9. 2009
    ..Increasing evidence suggests that air pollution adversely affects pregnancy outcomes. Yet few studies have examined how local traffic-generated emissions affect preeclampsia in addition to preterm birth...
  26. doi Maternal inflammation, growth retardation, and preterm birth: insights into adult cardiovascular disease
    Lynette K Rogers
    The Center for Perinatal Research, The Research Institute at Nationwide Children s Hospital, The Ohio State University, Columbus, Ohio, USA
    Life Sci 89:417-21. 2011
    ..The intrauterine environment is dramatically impacted by the overall maternal health. Both premature birth or low birth weight can result from a variety of maternal conditions including undernutrition or dysnutrition,..
  27. pmc 'Kangaroo mother care' to prevent neonatal deaths due to preterm birth complications
    Joy E Lawn
    Saving Newborn Lives Save the Children USA, Cape Town, South Africa
    Int J Epidemiol 39:i144-54. 2010
    ..Whilst increasingly accepted in both high- and low-income countries, a Cochrane review (2003) did not find evidence of KMC's mortality benefit, and did not report neonatal-specific data...
  28. ncbi Is antiretroviral therapy during pregnancy associated with an increased risk of preterm delivery, low birth weight, or stillbirth?
    Amanda M Cotter
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Miami, Miami, Florida 33101, USA
    J Infect Dis 193:1195-201. 2006
    ..Our objective was to investigate whether antiretroviral therapy was associated with adverse pregnancy outcome at a single site...
  29. pmc Effect of neighbourhood income and maternal education on birth outcomes: a population-based study
    Zhong Cheng Luo
    Department of Epidemiology and Biostatistics, McGill University, Montreal, Que
    CMAJ 174:1415-20. 2006
    ..We sought to determine the extent to which associations between adverse birth outcomes and SES can be identified using individual-level measures (maternal level of education) and community-level measures (neighbourhood income)...
  30. ncbi Changes in the gestational age distribution among U.S. singleton births: impact on rates of late preterm birth, 1992 to 2002
    Michael J Davidoff
    National Office, March of Dimes, White Plains, NY 10605, USA
    Semin Perinatol 30:8-15. 2006
    ..These observations, in addition to emerging evidence of increased morbidity, suggest the need for investigation of optimal obstetric and neonatal management of these late preterm infants...
  31. pmc Ambient air pollution and adverse birth outcomes: methodologic issues in an emerging field
    Beate Ritz
    Department of Epidemiology, School of Public Health, University of California, Los Angeles, CA 90095 1772, USA
    Basic Clin Pharmacol Toxicol 102:182-90. 2008
    ..Investigating biological mechanisms (e.g. using ultrasound measurements and biomarkers for hypothesized pathways) is an important remaining issue...
  32. doi Socioeconomic disparities in adverse birth outcomes: a systematic review
    Philip Blumenshine
    Center on Social Disparities in Health, Department of Family and Community Medicine, University of California San Francisco, San Francisco, California 94118, USA
    Am J Prev Med 39:263-72. 2010
    ....
  33. doi Inflammation and pregnancy
    John R Challis
    Michael Johnson Foundation for Health Research, Vancouver, Canada
    Reprod Sci 16:206-15. 2009
    ..The interaction between tissue remodeling factors, like matrix metalloproteinases, and vasoactive/hemostatic factors, like prostaglandin and coagulation factors, mediates this adaptive response...
  34. pmc Emergence of resting state networks in the preterm human brain
    Valentina Doria
    Institute of Clinical Sciences, Imperial College London, London W12 0HS, United Kingdom
    Proc Natl Acad Sci U S A 107:20015-20. 2010
    ..These results place the emergence of RSNs largely during the period of rapid neural growth in the third trimester of gestation, suggesting that they are formed before the acquisition of cognitive competencies in later childhood...
  35. doi Association between a Mediterranean-type diet and risk of preterm birth among Danish women: a prospective cohort study
    Tina B Mikkelsen
    Maternal Nutrition Group, Danish Epidemiology Science Centre, Statens Serum Institut, Copenhagen S, Denmark
    Acta Obstet Gynecol Scand 87:325-30. 2008
    ..Many studies have focused on the woman's diet, but most have been discouraging. The aim of the present study was to examine if maternal intake of a Mediterranean-type diet (MD) is associated with reduced risk of preterm birth...
  36. ncbi A meta-analysis of pregnancy outcomes in women with polycystic ovary syndrome
    C M Boomsma
    Department of Reproductive Medicine and Gynaecology, University Medical Center Utrecht, Utrecht, The Netherlands
    Hum Reprod Update 12:673-83. 2006
    ..07; 95% CI: 1.03-9.21), unrelated to multiple births. In conclusion, women with PCOS are at increased risk of pregnancy and neonatal complications. Pre-pregnancy, antenatal and intrapartum care should be aimed at reducing these risks...
  37. pmc Quantifying the impact of deprivation on preterm births: a retrospective cohort study
    David Taylor-Robinson
    Department of Public Health and Policy, University of Liverpool, Liverpool, United Kingdom
    PLoS ONE 6:e23163. 2011
    ..Our objective was to identify risk factors for preterm birth in the UK's largest maternity unit, with a particular focus on social deprivation, and related factors...
  38. ncbi Neonatal and 5-year outcomes after birth at 30-34 weeks of gestation
    Stephane Marret
    Department of Neonatal Medicine, Rouen University Hospital and Inserm Avenir Research Group, Institute for Biomedical Research, University of Rouen, Rouen, France
    Obstet Gynecol 110:72-80. 2007
    ..To evaluate the rates of in-hospital death, neonatal complications, and 5-year outcomes of infants born at 30-34 weeks of gestation...
  39. doi Diversity of microbes in amniotic fluid
    Daniel B Digiulio
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305 5107, USA
    Semin Fetal Neonatal Med 17:2-11. 2012
    ..The microbial census of the amniotic cavity remains unfinished. A more complete understanding may inform future research directions leading to improved strategies for preventing, diagnosing and treating MIAC...
  40. doi Neighbourhood socioeconomic status, maternal education and adverse birth outcomes among mothers living near highways
    M Genereux
    Community Medicine Residency Program, Faculte de Medecine, Universite de Montreal, Quebec, Canada
    J Epidemiol Community Health 62:695-700. 2008
    ..We evaluated whether proximity to highway interacts with individual and neighbourhood socioeconomic status (SES) to influence birth outcomes...
  41. pmc Vaginal progesterone in women with an asymptomatic sonographic short cervix in the midtrimester decreases preterm delivery and neonatal morbidity: a systematic review and metaanalysis of individual patient data
    Roberto Romero
    Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, and Detroit, MI, USA
    Am J Obstet Gynecol 206:124.e1-19. 2012
    ..To determine whether the use of vaginal progesterone in asymptomatic women with a sonographic short cervix (≤ 25 mm) in the midtrimester reduces the risk of preterm birth and improves neonatal morbidity and mortality...
  42. pmc The effect of changing patterns of obstetric care in Scotland (1980-2004) on rates of preterm birth and its neonatal consequences: perinatal database study
    Jane E Norman
    University of Edinburgh Centre for Reproductive Biology, Edinburgh, UK
    PLoS Med 6:e1000153. 2009
    ..We aimed, in a population-based database of 5 million people, to determine the temporal trends and obstetric antecedents of singleton preterm birth and its associated neonatal mortality and morbidity for the period 1980-2004...
  43. pmc Causes of stillbirths and early neonatal deaths: data from 7993 pregnancies in six developing countries
    Nhu Thi Nguyen Ngoc
    Hung Vuong Hospital, 128 Hungvuong Street, 105 Ho Chi Minh City, Viet Nam
    Bull World Health Organ 84:699-705. 2006
    ....
  44. doi Socio-economic inequality in preterm birth: a comparative study of the Nordic countries from 1981 to 2000
    Christina B Petersen
    National Institute of Public Health, Copenhagen, Denmark
    Paediatr Perinat Epidemiol 23:66-75. 2009
    ..Consequently, the socio-economic inequalities in preterm birth were not strongly influenced by structural changes during the period...
  45. pmc Recent advances in understanding the microbiology of the female reproductive tract and the causes of premature birth
    Xia Zhou
    Initiative for Bioinformatics and Evolutionary Studies, University of Idaho, Moscow, ID 83844 3051, USA
    Infect Dis Obstet Gynecol 2010:737425. 2010
    ..Further research is needed to establish whether an ascending pathway from the vagina to the amniotic cavity enables the development of intrauterine infections...
  46. pmc An evolutionary genomic approach to identify genes involved in human birth timing
    Jevon Plunkett
    Department of Pediatrics, Vanderbilt University School of Medicine and Monroe Carell Jr Children s Hospital at Vanderbilt, Nashville, Tennessee, United States of America
    PLoS Genet 7:e1001365. 2011
    ..We anticipate other human accelerated genes will similarly be associated with preterm birth risk and elucidate essential pathways for human parturition...
  47. doi Decreased term and postterm birthweight in the United States: impact of labor induction
    Xun Zhang
    Department of Pediatrics, McGill University Faculty of Medicine, Montreal, Quebec, Canada
    Am J Obstet Gynecol 203:124.e1-7. 2010
    ..We sought to assess recent trends in falling mean birthweight (BW) and gestational age (GA) among US non-Hispanic white singleton live births >or=37 weeks of gestation and the contribution of increased rates of induction to these trends...
  48. doi Neonatal mortality and morbidity rates in late preterm births compared with births at term
    Donald D McIntire
    Department of Obstetrics and Gynecology, The University of Texas Southwestern Medical Center, Dallas, Texas 75235 9032, USA
    Obstet Gynecol 111:35-41. 2008
    ....
  49. doi Traffic-related air pollution, preterm birth and term birth weight in the PIAMA birth cohort study
    Ulrike Gehring
    Institute for Risk Assessment Sciences, Utrecht University, PO Box 80178, 3508 TD Utrecht, The Netherlands
    Environ Res 111:125-35. 2011
    ..Maternal exposure to air pollution has been associated with adverse pregnancy outcomes. Few studies took into account the spatial and temporal variation of air pollution levels...
  50. ncbi Use of antiretroviral therapy in pregnant HIV-infected women and the risk of premature delivery: a meta-analysis
    Athena P Kourtis
    Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    AIDS 21:607-15. 2007
    ..The use of antiretroviral agents in pregnant HIV-infected women has been reported to increase the risk of premature delivery in some studies. We performed a meta-analysis on relevant studies to address this question...
  51. doi Low birthweight and premature birth are both associated with type 2 diabetes in a random sample of middle-aged Danes
    K Pilgaard
    Steno Diabetes Center, Niels Steensens Vej 1, 2820 Gentofte, Denmark
    Diabetologia 53:2526-30. 2010
    ..We studied the associations of size at birth and prematurity with type 2 diabetes, insulin sensitivity and beta cell function in the Danish population-based Inter99 study (ClinicalTrials.gov NCT00289237)...
  52. pmc Overweight and obesity in mothers and risk of preterm birth and low birth weight infants: systematic review and meta-analyses
    Sarah D McDonald
    McMaster University, Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Hamilton, ON, L8N 3Z5 Canada
    BMJ 341:c3428. 2010
    ..To determine the relation between overweight and obesity in mothers and preterm birth and low birth weight in singleton pregnancies in developed and developing countries...
  53. doi Prevention of preeclampsia and intrauterine growth restriction with aspirin started in early pregnancy: a meta-analysis
    Emmanuel Bujold
    Department of Obstetrics and Gynecology, Faculty of Medicine, Laval University, Quebec, Canada
    Obstet Gynecol 116:402-14. 2010
    ..To estimate the effect of low-dose aspirin started in early pregnancy on the incidence of preeclampsia and intrauterine growth restriction (IUGR)...
  54. doi One-year survival of extremely preterm infants after active perinatal care in Sweden
    Vineta Fellman
    Department of Obstetrics and Gynecology, Lund University Hospital, S 221 85 Lund, Sweden
    JAMA 301:2225-33. 2009
    ..Up-to-date information on infant survival after extremely preterm birth is needed for assessing perinatal care services, clinical guidelines, and parental counseling...
  55. pmc Longitudinal analysis of neural network development in preterm infants
    Christopher D Smyser
    Department of Neurology, Division of Pediatric Neurology, Washington University School ofMedicine, 660 South Euclid Avenue, Saint Louis, MO 63110 1093, USA
    Cereb Cortex 20:2852-62. 2010
    ....
  56. ncbi Maternal-fetal conditions necessitating a medical intervention resulting in preterm birth
    Cande V Ananth
    Division of Epidemiology and Biostatistics, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ 08901 1977, USA
    Am J Obstet Gynecol 195:1557-63. 2006
    ..The objective of the study was to evaluate the extent to which maternal and fetal conditions necessitate medically indicated preterm birth...
  57. ncbi Familial patterns of preterm delivery: maternal and fetal contributions
    Allen J Wilcox
    Epidemiology Branch, National Institute of Environmental Health Sciences, Durham, NC 27709, USA
    Am J Epidemiol 167:474-9. 2008
    ..The increased risk of preterm delivery among mothers born preterm is consistent with heritable maternal phenotypes that confer a propensity to deliver preterm...
  58. doi Primary, secondary, and tertiary interventions to reduce the morbidity and mortality of preterm birth
    Jay D Iams
    Department of Obstetrics and Gynecology, Ohio State University, Columbus, OH, USA
    Lancet 371:164-75. 2008
    ..Advances in primary and secondary care, following strategies used for other complex health problems, such as cervical cancer, will be needed to prevent prematurity-related illness in infants and children...
  59. pmc Maternal obesity in early pregnancy and risk of spontaneous and elective preterm deliveries: a retrospective cohort study
    Gordon C S Smith
    Department of Obstetrics and Gynaecology, Cambridge University, Rosie Maternity Hospital, Cambridge, England
    Am J Public Health 97:157-62. 2007
    ..We sought to determine the association between maternal body mass index and risk of preterm delivery...
  60. doi The preterm birth syndrome: issues to consider in creating a classification system
    Robert L Goldenberg
    Department of Obstetrics and Gynecology, Drexel University, Philadelphia, PA, USA
    Am J Obstet Gynecol 206:113-8. 2012
    ....
  61. doi Preterm birth and low birth weight among in vitro fertilization singletons: a systematic review and meta-analyses
    Sarah D McDonald
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Canada
    Eur J Obstet Gynecol Reprod Biol 146:138-48. 2009
    ..4 weeks). In conclusion, IVF singletons have significantly increased risks of PTB, LBW and other adverse perinatal outcomes compared to spontaneously conceived singletons after matching or controlling for maternal age at least...
  62. doi Risk factors and outcomes associated with first-trimester fetal growth restriction
    Dennis O Mook-Kanamori
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    JAMA 303:527-34. 2010
    ..Adverse environmental exposures lead to developmental adaptations in fetal life. The influences of maternal physical characteristics and lifestyle habits on first-trimester fetal adaptations and the postnatal consequences are not known...
  63. pmc Maternal contributions to preterm delivery
    Heather A Boyd
    Department of Epidemiology Research, Statens Serum Institut, Artillerivej 5, DK 2300 Copenhagen, Denmark
    Am J Epidemiol 170:1358-64. 2009
    ..The substantial portion of PTD risk explained by effects passed through the female line suggests a role for either imprinting or mitochondrial inheritance...
  64. ncbi Secular trends in socio-economic status and the implications for preterm birth
    John M D Thompson
    The Medical Birth Registry of Norway, Locus of Registry Based Epidemiology, University of Bergen, Bergen, Norway
    Paediatr Perinat Epidemiol 20:182-7. 2006
    ..In conclusion, the preterm birth rate increased over time, but was mainly due to an increase in obstetric interventions. No closing of the gap between socio-economic groups was observed...
  65. ncbi Neighborhood deprivation and preterm birth among non-Hispanic Black and White women in eight geographic areas in the United States
    Patricia O'Campo
    Centre for Research on Inner City Health, St Michael s Hospital, Toronto, Ontario, Canada
    Am J Epidemiol 167:155-63. 2008
    ..08, 1.23) for non-Hispanic Blacks. In this study, deprivation at the neighborhood level was significantly associated with increased risk of preterm birth among both non-Hispanic White women and non-Hispanic Black women...
  66. doi Maternal effects for preterm birth: a genetic epidemiologic study of 630,000 families
    Anna C Svensson
    Division of Public Health Epidemiology, Department of Public Health Sciences, Karolinska Institutet, Norrbacka, Fifth Floor, SE 171 76 Stockholm, Sweden
    Am J Epidemiol 170:1365-72. 2009
    ..The increased odds ratio between offspring of sisters was independent of maternal risk factors for preterm birth, suggesting that the relative importance of maternal effects is not explained by these well-known risk factors...
  67. ncbi Cost of hospitalization for preterm and low birth weight infants in the United States
    Rebecca B Russell
    March of Dimes, 1275 Mamaroneck Ave, White Plains, NY 10605, USA
    Pediatrics 120:e1-9. 2007
    ..The objective of this study was to estimate national hospital costs for infant admissions that are associated with preterm birth/low birth weight...
  68. doi Effect of late-preterm birth and maternal medical conditions on newborn morbidity risk
    Carrie K Shapiro-Mendoza
    Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30341 3717, USA
    Pediatrics 121:e223-32. 2008
    ..We compared late-preterm and term (37-41 weeks' gestation) infants with and without selected maternal medical conditions and assessed the independent and joint effects of these exposures on newborn morbidity risk...
  69. doi Methodological issues in studies of air pollution and reproductive health
    Tracey J Woodruff
    Program on Reproductive Health and the Environment, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA
    Environ Res 109:311-20. 2009
    ..This work is of critical public health importance because of widespread exposure and because perinatal outcomes are important markers of future child and adult health...
  70. ncbi Association of genetic variants, ethnicity and preterm birth with amniotic fluid cytokine concentrations
    Ramkumar Menon
    The Perinatal Research Center, Nashville, TN, USA
    Ann Hum Genet 74:165-83. 2010
    ..AF cytokine concentrations were associated with interactions between genotype and PTB in African Americans, but less so in Caucasians...
  71. ncbi Increase in preterm births in Brazil: review of population-based studies
    Mariângela F Silveira
    Departamento Materno Infantil, Faculdade de Medicina, Universidade Federal de Pelotas, Pelotas, RS, Brasil
    Rev Saude Publica 42:957-64. 2008
    ..The greatest cause of infant mortality in Brazil is perinatal conditions, mostly associated with preterm delivery. The objective of the study was to evaluate the evolution of preterm delivery rates in Brazil...
  72. pmc Using new satellite based exposure methods to study the association between pregnancy PM₂.₅ exposure, premature birth and birth weight in Massachusetts
    Itai Kloog
    Department of Environmental Health Exposure, Epidemiology and Risk Program, Harvard School of Public Health, Landmark Center, 401 Park Dr West, Boston, MA 02215, USA
    Environ Health 11:40. 2012
    Adverse birth outcomes such as low birth weight and premature birth have been previously linked with exposure to ambient air pollution...
  73. pmc Under-attending free antenatal care is associated with adverse pregnancy outcomes
    Kaisa Raatikainen
    Department of Obstetrics and Gynecology, PO Box 1777, Kuopio University Hospital, 70211 Kuopio, Finland
    BMC Public Health 7:268. 2007
    ..The objective of this study was to assess the outcome of pregnancies when free and easily accessible antenatal care has been either totally lacking or low in number of visits...
  74. doi Preterm birth and inhaled corticosteroid use in 6- to 19-year-olds: a Swedish national cohort study
    Hartmut Vogt
    Division of Pediatrics, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Pediatrics 127:1052-9. 2011
    ..In this study, we examined the risk of asthma in a national cohort of schoolchildren grouped according to degree of immaturity expressed as completed gestational weeks at birth...
  75. doi Diagnostic biomarkers of pro-inflammatory immune-mediated preterm birth
    Tobias Weissenbacher
    1st Department of Obstetrics and Gynaecology, Ludwig Maximilians University, Maistrasse 11, 80337 Munich, Germany
    Arch Gynecol Obstet 287:673-85. 2013
    ..Diagnosing intrauterine inflammation at an early stage is tremendously important. Amniotic fluid interleukin (IL)-6 concentration is currently the most investigated diagnostic tool for detecting intrauterine inflammation...
  76. pmc Vaginal progesterone reduces the rate of preterm birth in women with a sonographic short cervix: a multicenter, randomized, double-blind, placebo-controlled trial
    S S Hassan
    Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Department of Health and Human Services, Bethesda, MD, USA
    Ultrasound Obstet Gynecol 38:18-31. 2011
    ..This study was undertaken to determine the efficacy and safety of using micronized vaginal progesterone gel to reduce the risk of preterm birth and associated neonatal complications in women with a sonographic short cervix...
  77. pmc Prenatal exposure to airborne polycyclic aromatic hydrocarbons and risk of intrauterine growth restriction
    Hyunok Choi
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Environ Health Perspect 116:658-65. 2008
    ..Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous air pollutants generated by combustion of organic material, including fossil fuel...
  78. pmc Intakes of garlic and dried fruits are associated with lower risk of spontaneous preterm delivery
    Ronny Myhre
    Department of Genes and Environment, Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway
    J Nutr 143:1100-8. 2013
    ..In particular, garlic was associated with overall lower risk of spontaneous PTD. Dried fruits, especially raisins, were associated with reduced risk of PPROM. ..
  79. doi The neural basis of response inhibition and attention allocation as mediated by gestational age
    Emma J Lawrence
    Department of Psychological Medicine, Institute of Psychiatry, King s College London, United Kingdom
    Hum Brain Mapp 30:1038-50. 2009
    ....
  80. ncbi Should spontaneous and medically indicated preterm births be separated for studying aetiology?
    David A Savitz
    Carolina Population Center, University of North Carolina, Chapel Hill, NC 27599 7435, USA
    Paediatr Perinat Epidemiol 19:97-105. 2005
    ..Given the complexity of the aetiological pathways, both aggregation and disaggregation are well justified and should be included in studies of the causes of preterm birth...
  81. doi Novel biomarkers for the prediction of the spontaneous preterm birth phenotype: a systematic review and meta-analysis
    A Conde-Agudelo
    Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Department of Health and Human Services, Bethesda, MD, USA
    BJOG 118:1042-54. 2011
    ..Being able to predict preterm birth is important, as it may allow a high-risk population to be selected for future interventional studies and help in understanding the pathways that lead to preterm birth...
  82. doi Lung and systemic inflammation in preterm lambs on continuous positive airway pressure or conventional ventilation
    Graeme R Polglase
    School of Women s and Infants Health, The University of Western Australia, Perth, Western Australia 6009, Australia
    Pediatr Res 65:67-71. 2009
    ..Blood neutrophils decreased similarly after LPS in CPAP and CMV groups. Cytokine markers of lung injury or the systemic response to intratracheal LPS were not decreased by CPAP relative to CMV, in preterm lambs..
  83. doi Obstetrician-gynecologists' practices regarding preterm birth at the limit of viability
    Maria A Morgan
    American College of Obstetricians and Gynecologists, Washington, DC 20024, USA
    J Matern Fetal Neonatal Med 21:115-21. 2008
    ..To assess obstetrician-gynecologists' judgments of gestational age of viability and earliest age of medical intervention for preterm delivery, and to associate these practice decisions with physician characteristics...
  84. ncbi Association of DDT and DDE with birth weight and length of gestation in the Child Health and Development Studies, 1959-1967
    Lili Farhang
    San Francisco Department of Public Health, San Francisco, CA 94102, USA
    Am J Epidemiol 162:717-25. 2005
    ..27) for DDT; none of the study results achieved statistical significance. Given the persistence of DDT in the environment and its continuing role in malaria control, studies using more robust data should continue to assess this relation...
  85. doi Periconceptional intake of folic acid and food folate and risks of preterm delivery
    Gary M Shaw
    Stanford University School of Medicine, Stanford, California, USA
    Am J Perinatol 28:747-52. 2011
    ..Findings suggest some evidence that folates influenced risks; however, an interpretation of results was also consistent with no association between intake of folates and preterm delivery...
  86. pmc Abnormal microstructure of the atrophic thalamus in preterm survivors with periventricular leukomalacia
    A C Nagasunder
    Department of Radiology, Childrens Hospital, Los Angeles, California, USA
    AJNR Am J Neuroradiol 32:185-91. 2011
    ....
  87. pmc Reduced birthweight in short or primiparous mothers: physiological or pathological?
    X Zhang
    Department of Pediatrics, McGill University, Faculty of Medicine, Montreal, QC, Canada
    BJOG 117:1248-54. 2010
    ..Maternal height and parity are among the characteristics widely assumed to be physiological. Our objective was to test that assumption by using an association with perinatal mortality as evidence of a pathological effect...
  88. doi An overview of racial disparities in preterm birth rates: caused by infection or inflammatory response?
    Ramkumar Menon
    Department of Epidemiology, Women and Children s Center, Emory University Rollins School of Public Health, Atlanta, GA 30322, USA
    Acta Obstet Gynecol Scand 90:1325-31. 2011
    ....
  89. ncbi Spontaneous preterm birth of liveborn infants in women at low risk in Australia over 10 years: a population-based study
    S K Tracy
    Australian Institute of Health and Welfare National Perinatal Statistics Unit, University of New South Wales, Randwick, Australia
    BJOG 114:731-5. 2007
    ..To describe a 10-year trend in preterm birth...
  90. pmc Reference population for international comparisons and time trend surveillance of preterm delivery proportions in three countries
    Nils Halvdan Morken
    Department of Obstetrics and Gynecology, Telemark Hospital, Skien, Norway
    BMC Womens Health 8:16. 2008
    ..International comparison and time trend surveillance of preterm delivery rates is complex. New techniques that could facilitate interpretation of such rates are needed...
  91. doi Pregnancy outcomes for nulliparous women of advanced maternal age in South Australia, 1998-2008
    Isobel Ludford
    Office of Public Health, Department for Health and Ageing, 11 Hindmarsh Square, Adelaide, SA 5000, Australia
    Aust N Z J Obstet Gynaecol 52:235-41. 2012
    ..Child bearing in the later reproductive years has become increasingly common in Australia with potential implications for clinical practice...
  92. doi Low gestational weight gain and the risk of preterm birth and low birthweight: a systematic review and meta-analyses
    Zhen Han
    Department of Obstetrics and Gynecology, First Affiliated Hospital of Xi an Jiao Tong University, Shaanxi Province, PR China
    Acta Obstet Gynecol Scand 90:935-54. 2011
    ..Low gestational weight gain is common, with potential adverse perinatal outcomes...
  93. doi Natural history of retinopathy of prematurity in infants born before 27 weeks' gestation in Sweden
    Dordi Austeng
    Department of Neuroscience, Uppsala University, 75185 Uppsala, Sweden
    Arch Ophthalmol 128:1289-94. 2010
    ..To investigate the natural history of retinopathy of prematurity (ROP) in 506 extremely preterm infants born before 27 weeks' gestation in Sweden during a 3-year period...
  94. ncbi Animal models of preterm birth
    Michal A Elovitz
    Center for Research on Reproduction and Women s Health, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA 19104 6142, USA
    Trends Endocrinol Metab 15:479-87. 2004
    ..An understanding of such models will hopefully promote continued research that will ultimately lead to a decrease in preterm birth and an improvement in neonatal outcome...
  95. doi Birth outcomes after induced abortion: a nationwide register-based study of first births in Finland
    R Klemetti
    National Institute for Health and Welfare THL, PO Box 30, 00271 Helsinki, Finland
    Hum Reprod 27:3315-20. 2012
    ..Is the perinatal health of first-born children affected by the mother's previous induced abortion(s) (IAs)?..
  96. pmc Educational inequalities in perinatal outcomes: the mediating effect of smoking and environmental tobacco exposure
    Gerrit van den Berg
    Department of Pediatrics, VU University Medical Center, Amsterdam, The Netherlands
    PLoS ONE 7:e37002. 2012
    ....
  97. doi Low birthweight and preterm birth rates 1 year before and after the Irish workplace smoking ban
    Z Kabir
    Tobacco Free Research Institute RIFTFS, Dublin, Ireland
    BJOG 116:1782-7. 2009
    ..The comprehensive Irish workplace smoking ban was successfully introduced in March 2004. We examined LBW and preterm birth rates 1 year before and after the workplace smoking ban in Dublin...
  98. ncbi Preterm low birth weight and maternal periodontal status: a meta-analysis
    Jean Noel Vergnes
    Department of Epidemiology, Dental School, Toulouse, France
    Am J Obstet Gynecol 196:135.e1-7. 2007
    ..This study was undertaken to assess the effect of maternal periodontal disease on preterm delivery and/or birth of low-weight infants...
  99. doi Genetic and environmental contributions to racial disparities in preterm birth
    Siobhan M Dolan
    Department of Obstetrics and Gynecology and Women s Health, Albert Einstein College of Medicine, Bronx, NY, USA
    Mt Sinai J Med 77:160-5. 2010
    ....
  100. doi Pregnancy outcomes associated with viral hepatitis
    K L B Reddick
    Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC 27710, USA
    J Viral Hepat 18:e394-8. 2011
    ..Women with hepatitis have an increased risk for complications during pregnancy. Research to determine the efficacy and cost-effectiveness of counselling patients about potential risks for adverse outcomes is warranted...
  101. ncbi Epidemiology of preterm birth and neonatal outcome
    Shi Wu Wen
    OMNI Research Group, Department of Obstetrics and Gynecology, University of Ottawa, Ontario, Canada
    Semin Fetal Neonatal Med 9:429-35. 2004
    ..Future research should concentrate on the ways to reduce long-term health sequelae and developmental handicaps among survivors of infants born preterm, as well as elucidating the mechanisms and aetiology of preterm births...

Research Grants79

  1. Lactoferrin Enhances Growth and Reduces Nosocomial Infection in Preterm Infants
    Karel Petrak; Fiscal Year: 2009
    ..Marketing approval for TLF to treat NIs would be of great benefit to the patients and the community, and would also be of a substantial commercial value. ..
  2. Triggers of Abruptio Placentae - A Case Crossover Study of an Ischemic Placental
    Michelle A Williams; Fiscal Year: 2013
    ....
  3. The effect of trichloroethylene exposure on adverse pregnancy outcomes
    Iman Hassan; Fiscal Year: 2013
    ..Results from this project will provide new knowledge about potential mechanisms by which environmental toxicants may contribute to adverse birth outcomes. ..
  4. Novel Means to Establish Free Radical Balance in the Neonatal Premature Lung
    Prakash Jagtap; Fiscal Year: 2011
    ..PUBLIC HEALTH RELEVANCE: Premature birth is frequently associated with an acute respiratory disease that may convert to a long term crippling lung ..
  5. Antenatal Betamethasone in Late Preterm Gestation Lambs
    SATYANARAYANA LAKSHMINRUSIMHA; Fiscal Year: 2010
    ..We intend to administer betamethasone to late preterm gestation ewes to study the benefit and mechanism of this treatment in fetal lambs delivered by cesarean section. ..
  6. Outcomes of Infertility Treatments in Clinic and Population-Based Cohorts
    Joseph B Stanford; Fiscal Year: 2010
    ..The results of this study will describe clinically relevant outcomes for couples seeking to have healthy children and will also inform the development of future targeted randomized trials. ..
  7. The Impact of Sleep-Disordered Breathing on Adverse Pregnancy Outcomes
    LOUISE M O apos BRIEN; Fiscal Year: 2010
    ..Hypertension may lead to pre-eclampsia, which can restrict fetal growth or trigger premature birth. The rate of pre-eclampsia has increased by nearly one-third during the past decade...
  8. Flame Retardant and Adverse Perinatal Outcome (FRAPO)
    Morgan R Peltier; Fiscal Year: 2013
    ..This study will help fulfill the critical need to better understand the potential role of PBDEs, which were detectable in >90% of all pregnant women, on risk for adverse pregnancy outcomes. ..
  9. Human developmental toxicity of metal mixture exposure from e-waste recycling
    Aimin Chen; Fiscal Year: 2010
    ..This study will address the developmental effects of metal mixtures from primitive e-waste recycling activities. It will inform environmental health policy making to manage the e-waste and protect human health. ..
  10. Climate Change and Adverse Birth Outcomes: Assessing the Vulnerability of Pregnan
    Shao Lin; Fiscal Year: 2013
    ..The multidisciplinary research team has a unique opportunity to use the data already collected and geo-coded through the NBDPS and other ongoing projects, which ensures the project is feasible and sustainable. ..
  11. DHA attenuates Inflammatory Responses Through Altering RAGE Signaling
    LYNETTE KAY ROGERS; Fiscal Year: 2013
    ....
  12. Biochemical, Biomechanical & Morphological Properties of Quantitative Ultrasound
    Barbara L McFarlin; Fiscal Year: 2010
    ..Reducing the preterm birth rate to 7% in the United States is a goal of the Healthy People 2010 initiative, and it is only by reducing the incidence of preterm birth that infant mortality in the United States can be addressed. ..
  13. Role of Physico-chemical Properties in the Reprotoxicity of Inhaled Cd NP.
    JUDITH TERRY ZELIKOFF; Fiscal Year: 2010
    ....
  14. Right Heart-Pulmonary Vascular Interactions in Bronchopulmonary Dysplasia
    Marlowe Eldridge; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Premature birth is a major health care problem, affecting approximately 12% of all births and contributing to more than 85% of all perinatal complications and deaths...
  15. Iodine Nutrition and Thyroid Disease During Pregnancy and Lactation
    ANGELA MEI TIN LEUNG; Fiscal Year: 2013
    ..of this proposal is to test the hypotheses that: 1) hypothyroidism during pregnancy is associated with premature birth and other adverse obstetric/perinatal outcomes, and 2) breast milk perchlorate and thiocyanate levels, by ..
  16. Air Pollution, Inflammation and Preterm Birth: A Mechanistic Study in Mexico City
    MARIE SYLVIA O'NEILL; Fiscal Year: 2012
    ..abstract_text> ..
  17. Pluripotent Stem Cells: Modeling syncytiotrophoblast development and pathogenesis
    Danny J Schust; Fiscal Year: 2013
    ..turnover have been implicated in placental disease, including preeclampsia (PE), the leading single cause of premature birth. STB is the source of "placental debris", cytokines, and pro-inflammatory and anti-angiogenic proteins, which ..
  18. Reducing Preterm Births in Underserved Pregnant Women
    JAMES G CHRISTIAN; Fiscal Year: 2011
    ..8 percent of babies (more than 500,000 per year) are born prematurely. The rate of premature birth has increased by 36 percent since the early 1980s...
  19. Role of VEGF in Perinatal Hypertension
    STEVEN HERBERT ABMAN; Fiscal Year: 2013
    ..However, bronchopulmonary dysplasia (BPD), the chronic lung disease that follows premature birth, remains a major cause of perinatal morbidity and mortality...
  20. Genomic actions of progesterone receptors in human myometrial cells
    Sam Mesiano; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Premature birth is a major public health problem that causes 70-80% of neonatal morbidity and mortality...
  21. DAMP-RAGE Signaling and Fetal Injury in Inflammation-Induced Preterm Birth
    Irina A Buhimschi; Fiscal Year: 2013
    ..abstract_text> ..
  22. Routine Aspiration of Residual Gastric Contents in Very Low Birth Weight Infants
    Leslie A Parker; Fiscal Year: 2013
    ..VLBW) infants is well known and necessary to facilitate optimal growth and development and reduce both premature birth-related and iatrogenic complications...
  23. Perinatal Assessment of At-Risk Populations
    William P Fifer; Fiscal Year: 2013
    ..In summary, our primary hypotheses focus on testing how known risk factors for SIDS (postnatal age, premature birth, sleep position, prenatal exposures) alter physiological function in the fetus and infant...
  24. Transforming Women's Health: Discovery, Development, and Delivery
    Ellen M Daley; Fiscal Year: 2012
    ..Such an approach to research, practice and policy is necessary to improve health and decrease disparities in women's health across the lifespan in Florida and beyond. ..
  25. Using a MALDI-TOF System for SNP Analysis
    Nadereh Jafari; Fiscal Year: 2010
    ....
  26. Anti-Phospholipid Multiplex For Pathologic Epitopes
    Paul O Neilsen; Fiscal Year: 2010
    ..This project will help define the biochemical causes of antiphospholipid disorders and improve their diagnosis bringing better understanding and diagnosis to researchers, physicians, and patients. ..
  27. VCU Building Interdisciplinary Research Careers in Women's Health
    Jerome F Strauss; Fiscal Year: 2011
    ....
  28. Predictors of Prenatal Care Providers Counseling Women on Tobacco Use/Exposure
    BETH LEONG PINELES; Fiscal Year: 2013
    ..With the variety of tools and datasets obtained and compiled for this project, we will gain a better understanding of which physicians follow PHS, USPSTF, and ACOG guidelines, and how to identify those who do not. ..
  29. Randomized Trial of Antenatal Late Preterm Steroids (ALPS) - Clinical Coordinatin
    Ronald Wapner; Fiscal Year: 2012
    ..If shown to reduce the need for respiratory support and thus to decrease the rate of special care nursery admissions and improve short-term outcomes, the public health and economic impact will be considerable. ..
  30. Role of endocrine-disrupting chemicals and social stress on perinatal outcomes
    Ami R Zota; Fiscal Year: 2012
    ..Results from this work will improve pregnancy outcomes and inform public health policy, particularly for vulnerable subpopulations, who often encounter elevated exposures to chemical and non-chemical stressors. ..
  31. The Vaginal Microbiome: Disease, Genetics and the Environment
    GREGORY ALLEN BUCK; Fiscal Year: 2012
    ..abstract_text> ..
  32. Structural determinants of DTI observations in developing cortex and white matter
    Christopher D Kroenke; Fiscal Year: 2013
    ..g. Rett syndrome, phenylketonuria), environmental (e.g. fetal alcohol spectrum disorder, premature birth), or multifactorial (e.g. autism, schizophrenia) origin...
  33. Maternal genitourinary infections and adverse perinatal outcomes
    Abdullah Hel Baqui; Fiscal Year: 2013
    ....
  34. MECHANISMS OF FETAL MEMBRANE RUPTURE
    Jerome F Strauss; Fiscal Year: 2010
    Preterm premature rupture of the fetal membranes (PPROM) is a major cause of maternal morbidity and premature birth. Studies conducted during the current period of support revealed that polymorphisms in genes encoding matrix ..
  35. Functional and Lymphocytic Markers of Respiratory Morbidity in Hyperoxic Preemies
    RITA MARIE RYAN; Fiscal Year: 2013
    ..that cellular and molecular immuno-maturity is altered due to intrinsic and extrinsic factors presented by premature birth in such a way as to reduce resistance to viral infections and to promote cytotoxic damage to the lung...
  36. Eunice Kennedy Shriver NICHD Maternal Fetal Medicine Units Network
    Edward K Chien; Fiscal Year: 2013
    ..Focusing on significant perinatal and long-term outcomes, we will bring to an end procedures and practices that are ineffective or incur undue risks. ..
  37. Impact of Exercise on Body Composition in Premature Infants: New Approaches
    Dan M Cooper; Fiscal Year: 2013
    ..b>Premature birth is recognized as the single most important health problem in maternal- child health in the US...
  38. Redox Regulation of Vascular cGMP Signaling in Neonatal Lungs
    Kathryn N Farrow; Fiscal Year: 2013
    ..They represent the most immediate therapeutic option for these infants if a rationale for their use can be demonstrated. ..
  39. Molecular Epidemiology of the Vaginal Microbiome
    Rebecca M Brotman; Fiscal Year: 2013
    ..This research will contribute valuable information on the causes of BV, help develop improved methods for diagnosing, preventing and treating BV, and may help reduce major reproductive health problems associated with BV. ..
  40. Cooperative Multicenter Maternal Fetal Medicine Units Networks
    John M Thorp; Fiscal Year: 2013
    ..This is particularly important in North Carolina as the state ranks in the bottom third of the nation with regard to perinatal/maternal health and infant mortality. ..
  41. The Role of Uncultivated Bacteria in Bacterial Vaginosis
    DAVID NEAL FREDRICKS; Fiscal Year: 2013
    ..If biofilms are shown to be important in BV, this would open many new avenues for treatment and prevention based on disruption of biofilm formation and cell signaling. ..
  42. Impact of Pregnancy on Drug Absorption, Disposition and End Organ Response
    Steve N Caritis; Fiscal Year: 2013
    ..Finally, we will evaluate the fetal contribution to the variability in activity of these three CYP enzymes by evaluating cord/placental CYP enzymes/polymorphisms. ..
  43. Maternal Stress, Obesity, and Influenza Virus Vaccine Immunogenicity in Pregnancy
    LISA MICHELLE CHRISTIAN; Fiscal Year: 2013
    ..This study will determine if it is justified to re-evaluate influenza vaccine recommendations for pregnant women with specific risk factors. ..
  44. Recombination in a Minimal Organism
    Patricia A Totten; Fiscal Year: 2013
    ..The potential impact of our focus on the molecular biology and pathogenesis of this understudied bacterium is great in that novel targets for intervention and treatment may be identified. ..
  45. Research Training Prog in Reproductive Biol & Med for Latin American Scientists
    John E Nestler; Fiscal Year: 2010
    ..abstract_text> ..
  46. Gestational Stress and Impaired Iron Homeostasis in the Young Infant
    Christopher L Coe; Fiscal Year: 2013
    ..illness, and inflammatory processes during pregnancy can impair fetal growth, affect the likelihood of premature birth and obstetrical complications, and increase the risk for a number of postnatal behavioral and health problems ..
  47. Detection and Quantification of Neonatal Intraventricular Hemorrhage
    Michael D Weiss; Fiscal Year: 2013
    ..One such pathology, neonatal intraventricular hemorrhage (IVH), is a common consequence of premature birth, with approximately 30 percent of infants weighing less than 1500 g having some degree of bleeding...
  48. Physiological reactivity to acute stress during pregnancy
    LISA MICHELLE CHRISTIAN; Fiscal Year: 2010
    ....
  49. Glial Interactions in Premyelinating Oligodendrocyte Destruction
    Jianrong Li; Fiscal Year: 2010
    ..matter lesion underlying cerebral palsy and a leading cause of chronic neurological deficits in survivors of premature birth. Inflammation associated with ischemia/hypoxia and maternal/fetal infection is a major determinant of the ..
  50. NICHD Cooperative Multicenter Neonatal Research Network
    Abbot R Laptook; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE (See instructions): Premature birth is associated with multiple morbidities which may lead to a lifetime of physical and mental disability...
  51. Adrenal function and adverse CV outcomes at age 6 after extremely preterm birth
    Kristi L Watterberg; Fiscal Year: 2013
    ..The accelerated review process of RFA-HL-13-003 will allow inclusion of approximately 340 eligible children if this application is funded by July1, 2013. ..
  52. Maternal and Child Health Benefits from Reducing Household Air Pollution
    Patricia L Hibberd; Fiscal Year: 2013
    ..The goal of this proposal is to participate in the Global Network for Women's and Children's Health Research and to study whether cook stoves and fuel that reduce HAP can improve pregnancy outcomes and child health. ..
  53. Improving Preterm Outcomes by Safeguarding Maternal Mental Health
    Michael Silverstein; Fiscal Year: 2013
    ..Our ultimate goal is to disseminate a safe and effective intervention applicable to all low-income families with preterm infants. ..
  54. INITIATION OF HUMAN LABOR: PREVENTION OF PREMATURITY
    Carole R Mendelson; Fiscal Year: 2013
    ..We propose that these interrelated projects, carried out by a highly interactive research team, will achieve the long-range goals of this Program and contribute to a reduction in the incidence of preterm birth. ..
  55. Artificial Placenta Device
    KATHRYN R OSTERHOLZER; Fiscal Year: 2013
    ..Prematurity is associated with substantial mortality, morbidity, and escalating cost. The complications of premature birth include respiratory, gastrointestinal, and central nervous system morbidity, and significant mortality...
  56. A new smart neonatal incubator for real-time detection of sepsis
    De Ann M Pillers; Fiscal Year: 2013
    ..Chorioamnionitis is a leading cause of prelabor preterm rupture of membranes (PPROM) and a leading cause of premature birth (<35 weeks)...
  57. Vitamin D: a link to racial disparities in birth outcomes
    Lisa M Bodnar; Fiscal Year: 2012
    ..Improving vitamin D status in pregnant women may be a simple strategy for reducing the excess cases of adverse birth outcomes among black women in the United States. ..
  58. Fetal Nicotine Exposure and Chemosensory Plasticity
    Steven L Youngentob; Fiscal Year: 2010
    ..These behavioral effects are in addition to stunted fetal growth, premature birth, stillbirths and increased mortality of newborn...
  59. Influence of the Enteric Microbiome on the Genesis of Bronchopulmonary Dysplasia
    Aaron Hamvas; Fiscal Year: 2013
    ..provided by applicant): Bronchopulmonary dysplasia (BPD) results from disrupted lung development after premature birth and results in life long pulmonary morbidity...
  60. Fetal Brain Damage: A Placental Disorder
    ANNA PENN; Fiscal Year: 2009
    ....
  61. Air pollution and fetal growth in China
    Yawei Zhang; Fiscal Year: 2013
    ..Because high energy consumption and increased automobile emissions degrade urban air quality in both developed and developing countries, understanding how ambient air pollution impacts fetal development is of public health significance. ..
  62. The Vaginal Microbiome: Disease, Genetics and the Environment
    Gregory Buck; Fiscal Year: 2009
    ....
  63. Primate Model of Mycoplasma genitalium
    Patricia A Totten; Fiscal Year: 2010
    ..Further establishment and characterization of this model will lead to future studies assessing the pathogenesis of M. genitalium as well as the evaluation of effective strategies for prevention and treatment. ..
  64. Air Pollution and Adverse Birth Outcomes
    Beate Ritz; Fiscal Year: 2004
    ..abstract_text> ..
  65. Tracking Air Pollutants and Newborn Health in Houston, Texas
    Elaine Symanski; Fiscal Year: 2011
    ....
  66. A Collaborative, Intersectional Approach to Health Disparities in Pregnancy
    Tina Bloom; Fiscal Year: 2007
    ..It will also bring needed health and resource information back to other women, for healthier mothers and babies in the future. [unreadable] [unreadable] [unreadable]..
  67. Wed Based Outreach for Pregnant African American Women
    JoAnne Herman; Fiscal Year: 2001
    ..Posttest data will be collected after 28 weeks gestation. Pretest and posttest measurement must be at least 10 weeks apart. The hypotheses will be tested using ANCOVA, ANOVA, Chi-Square, and test of proportion. ..
  68. Race Related Stressors and Preterm Birth in African American Women
    Carmen Giurgescu; Fiscal Year: 2009
    ..By understanding how neighborhood conditions and experiences of discrimination contribute to preterm birth, we can target programs and interventions that reduce the risk for preterm birth in African-American women. ..
  69. MORTALITY BY RACE AMONG LOW BIRTH WEIGHT INFANTS
    Robert Michielutte; Fiscal Year: 1990
    ..Analyses will be conducted separately for neonatal and postneonatal deaths...
  70. EPIDEMIOLOGY OF EXERTION, STRESS, AND PRETERM DELIVERY
    David Savitz; Fiscal Year: 2004
    ..abstract_text> ..
  71. Novel Complementary Therapy for Preterm Infants
    John Bauer; Fiscal Year: 2009
    ..We will carry out preclinical studies to define mechanistic actions and identify optimal conditions for potential efficacy using relevant human fetal intestinal epithelial cells and animal models of newborn intestinal injury. ..
  72. MOTOR-Maternal Oral Therapy to Reduce Obstetric Risk
    STEVEN NMN OFFENBACHER; Fiscal Year: 2010
    ..abstract_text> ..
  73. Childhood After Preterm Birth: The Preschool Years
    LISA MCELANEY; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  74. Placental Pathology: Digital Assessment and Validation
    Carolyn Salafia; Fiscal Year: 2009
    ..e., neutrophil number), as well as quantification of neutrophil karyorrhexis that may correlate with age/duration of infection more precisely than any current histologic method. ..
  75. Psychoneuroimmunology: Preterm Birth in Hispanics
    ROBERTA RUIZ; Fiscal Year: 2007
    ..Acculturation as a latent variable will be used with the AL score in SEM. We will add the mediating variables into the SEM and compare the model at 15-17 weeks and 22-24 weeks, concerned. ..
  76. Immortalization of Pregnant Human Myometrial Cells
    MELVYN SOLOFF; Fiscal Year: 2004
    ....
  77. Estimating Ultrasound Attenuation in Human Pregnant Cervix
    BARBARA L contact MCFARLIN; Fiscal Year: 2010
    ..The long-term goal of this research program is to develop a noninvasive ultrasound technique that will detect early cervical ripening in humans and lead to scientific interventions to modify preterm birth. ..
  78. Novel Cultivation Methods for the Domestication of Vaginal Bacteria
    DAVID NEAL FREDRICKS; Fiscal Year: 2012
    ....