pregnancy complications

Summary

Summary: Conditions or pathological processes associated with pregnancy. They can occur during or after pregnancy, and range from minor discomforts to serious diseases that require medical interventions. They include diseases in pregnant females, and pregnancies in females with diseases.

Top Publications

  1. ncbi Maternal morbid obesity and the risk of adverse pregnancy outcome
    Marie I Cedergren
    Division of Obstetrics and Gynecology, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linkoping University, SE 581 85 Linkoping, Sweden
    Obstet Gynecol 103:219-24. 2004
  2. ncbi Hyperglycemia and adverse pregnancy outcomes
    Boyd E Metzger
    Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    N Engl J Med 358:1991-2002. 2008
  3. ncbi Maternal mortality: who, when, where, and why
    Carine Ronsmans
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Lancet 368:1189-200. 2006
  4. ncbi 4 million neonatal deaths: when? Where? Why?
    Joy E Lawn
    Saving Newborn Lives Save the Children USA, and International Perinatal Care Unit, Institute of Child Health, London, Cape Town, South Africa
    Lancet 365:891-900. 2005
  5. ncbi International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)
    S Miyakis
    St George Hospital, University of New South Wales, Sydney, Australia
    J Thromb Haemost 4:295-306. 2006
  6. pmc Cognitive behaviour therapy-based intervention by community health workers for mothers with depression and their infants in rural Pakistan: a cluster-randomised controlled trial
    Atif Rahman
    School of Population, Community, and Behavioural Sciences, University of Liverpool, Liverpool, UK
    Lancet 372:902-9. 2008
  7. ncbi Perinatal depression: a systematic review of prevalence and incidence
    Norma I Gavin
    RTI International, 3040 Cornwallis Road, PO Box 12194, Research Triangle Park, NC 27709 2194, USA
    Obstet Gynecol 106:1071-83. 2005
  8. ncbi Diet-induced obesity in female mice leads to offspring hyperphagia, adiposity, hypertension, and insulin resistance: a novel murine model of developmental programming
    Anne Maj Samuelsson
    Division of Reproduction and Endocrinology, King s College London, London, UK
    Hypertension 51:383-92. 2008
  9. ncbi The prevalence of maternal near miss: a systematic review
    O Tuncalp
    Department of Population, Family and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    BJOG 119:653-61. 2012
  10. pmc Effects of interventions in pregnancy on maternal weight and obstetric outcomes: meta-analysis of randomised evidence
    S Thangaratinam
    Women s Health Research Unit, Centre for Primary Care and Public Health, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    BMJ 344:e2088. 2012

Detail Information

Publications368 found, 100 shown here

  1. ncbi Maternal morbid obesity and the risk of adverse pregnancy outcome
    Marie I Cedergren
    Division of Obstetrics and Gynecology, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linkoping University, SE 581 85 Linkoping, Sweden
    Obstet Gynecol 103:219-24. 2004
    To evaluate whether morbidly obese women have an increased risk of pregnancy complications and adverse perinatal outcomes.
  2. ncbi Hyperglycemia and adverse pregnancy outcomes
    Boyd E Metzger
    Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    N Engl J Med 358:1991-2002. 2008
    ..It is controversial whether maternal hyperglycemia less severe than that in diabetes mellitus is associated with increased risks of adverse pregnancy outcomes...
  3. ncbi Maternal mortality: who, when, where, and why
    Carine Ronsmans
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Lancet 368:1189-200. 2006
    ..Inequalities in the risk of maternal death exist everywhere. Targeting of interventions to the most vulnerable--rural populations and poor people--is essential if substantial progress is to be achieved by 2015...
  4. ncbi 4 million neonatal deaths: when? Where? Why?
    Joy E Lawn
    Saving Newborn Lives Save the Children USA, and International Perinatal Care Unit, Institute of Child Health, London, Cape Town, South Africa
    Lancet 365:891-900. 2005
    ..While we neglect these challenges, 450 newborn children die every hour, mainly from preventable causes, which is unconscionable in the 21st century...
  5. ncbi International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)
    S Miyakis
    St George Hospital, University of New South Wales, Sydney, Australia
    J Thromb Haemost 4:295-306. 2006
    ..Based on this, we propose amendments to the Sapporo criteria. We also provide definitions on features of APS that were not included in the updated criteria...
  6. pmc Cognitive behaviour therapy-based intervention by community health workers for mothers with depression and their infants in rural Pakistan: a cluster-randomised controlled trial
    Atif Rahman
    School of Population, Community, and Behavioural Sciences, University of Liverpool, Liverpool, UK
    Lancet 372:902-9. 2008
    ..We integrated a cognitive behaviour therapy-based intervention into the routine work of community-based primary health workers in rural Pakistan and assessed the effect of this intervention on maternal depression and infant outcomes...
  7. ncbi Perinatal depression: a systematic review of prevalence and incidence
    Norma I Gavin
    RTI International, 3040 Cornwallis Road, PO Box 12194, Research Triangle Park, NC 27709 2194, USA
    Obstet Gynecol 106:1071-83. 2005
    ..We systematically review evidence on the prevalence and incidence of perinatal depression and compare these rates with those of depression in women at non-childbearing times...
  8. ncbi Diet-induced obesity in female mice leads to offspring hyperphagia, adiposity, hypertension, and insulin resistance: a novel murine model of developmental programming
    Anne Maj Samuelsson
    Division of Reproduction and Endocrinology, King s College London, London, UK
    Hypertension 51:383-92. 2008
    ..Developmentally programmed hyperphagia, physical inactivity, and altered adipocyte metabolism may play a mechanistic role...
  9. ncbi The prevalence of maternal near miss: a systematic review
    O Tuncalp
    Department of Population, Family and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    BJOG 119:653-61. 2012
    ..Severe maternal morbidity or 'near miss' is a promising indicator to improve quality of obstetric care...
  10. pmc Effects of interventions in pregnancy on maternal weight and obstetric outcomes: meta-analysis of randomised evidence
    S Thangaratinam
    Women s Health Research Unit, Centre for Primary Care and Public Health, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    BMJ 344:e2088. 2012
    ..To evaluate the effects of dietary and lifestyle interventions in pregnancy on maternal and fetal weight and to quantify the effects of these interventions on obstetric outcomes...
  11. ncbi Maternal obesity and pregnancy outcome: a study of 287,213 pregnancies in London
    N J Sebire
    Department of Obstetrics and Gynaecology, Imperial College School of Medicine at St Mary's Hospital, London, UK
    Int J Obes Relat Metab Disord 25:1175-82. 2001
    ..The basis of many of the complications is likely to be related to the altered metabolic state associated with morbid obesity...
  12. ncbi Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses
    Tim F Oberlander
    Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    Epigenetics 3:97-106. 2008
    ....
  13. ncbi Caesarean delivery rates and pregnancy outcomes: the 2005 WHO global survey on maternal and perinatal health in Latin America
    Jose Villar
    UNDP UNFPA WHO World Bank Special Programme of Research, Development and Research Training in Human Reproduction, Department of Reproductive Health and Research, WHO, 1211 Geneva 27, Switzerland
    Lancet 367:1819-29. 2006
    ..Our aim was to assess the association between caesarean delivery and pregnancy outcome at the institutional level, adjusting for the pregnant population and institutional characteristics...
  14. ncbi WHO antenatal care randomised trial for the evaluation of a new model of routine antenatal care
    J Villar
    UNDP UNFPA WHO World Bank Special Programme of Research, Development, and Research Training in Human Reproduction, Department of Reproductive Health and Research, World Health Organisation, Geneva, Switzerland
    Lancet 357:1551-64. 2001
    ..We undertook a multicentre randomised controlled trial that compared the standard model of antenatal care with a new model that emphasises actions known to be effective in improving maternal or neonatal outcomes and has fewer clinic visits...
  15. ncbi Maternal obesity: pregnancy complications, gestational weight gain and nutrition
    I Guelinckx
    Department of Nutrition and Health Preventive Medicine, Catholic University Leuven, University Hospital Gasthuisberg, Leuven, Belgium
    Obes Rev 9:140-50. 2008
    ..This review aims to summarize the complications associated with maternal prepregnancy overweight and obesity and to discuss possible strategies to improve the lifestyle habits of pregnant women...
  16. ncbi Maternal obesity is associated with dysregulation of metabolic, vascular, and inflammatory pathways
    Jane E Ramsay
    University Department of Obstetrics and Gynaecology, Glasgow Royal Infirmary, Scotland, G31 2ER, United Kingdom
    J Clin Endocrinol Metab 87:4231-7. 2002
    ..Clearly, these data provide further rationale to examine the potential benefits of preconceptual weight loss and antenatal exercise...
  17. pmc Incidence and predictors of severe obstetric morbidity: case-control study
    M Waterstone
    Department of Public Health Medicine, Guy's, King's College, and St Thomas's Hospitals Schools of Medicine and Dentistry, Capital House, London SE1 3QD
    BMJ 322:1089-93; discussion 1093-4. 2001
    ..Caesarean section quadruples the risk of morbidity. Development and evaluation of ways of predicting and reducing risk are required with particular emphasis paid on the management of haemorrhage and pre-eclampsia...
  18. ncbi Prevalence of depression during pregnancy: systematic review
    Heather A Bennett
    Faculty of Pharmacy and Department of Medicine, University of Toronto, Ontario, Canada
    Obstet Gynecol 103:698-709. 2004
    ....
  19. ncbi Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: a longitudinal study
    M K Javaid
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, UK
    Lancet 367:36-43. 2006
    ..We investigated the effect of maternal vitamin D status during pregnancy on childhood skeletal growth...
  20. ncbi Severe maternal morbidity during pregnancy, delivery and puerperium in the Netherlands: a nationwide population-based study of 371,000 pregnancies
    J J Zwart
    Department of Obstetrics, Leiden University Medical Centre, Leiden, The Netherlands
    BJOG 115:842-50. 2008
    ..To assess incidence, case fatality rate, risk factors and substandard care in severe maternal morbidity in the Netherlands...
  21. pmc Fetuses of obese mothers develop insulin resistance in utero
    Patrick M Catalano
    Department of Reproductive Biology, Case Western Reserve University at Metro Health Medical Center, Cleveland, Ohio, USA
    Diabetes Care 32:1076-80. 2009
    ..The purpose of this study was to determine whether fetuses of obese women have increased obesity, insulin resistance, and markers of inflammation, supporting the concept of fetal programming...
  22. ncbi Management of asthma in pregnancy guided by measurement of fraction of exhaled nitric oxide: a double-blind, randomised controlled trial
    Heather Powell
    Centre for Asthma and Respiratory Diseases, University of Newcastle and Hunter Medical Research Institute, Newcastle, NSW, Australia
    Lancet 378:983-90. 2011
    ..We tested the hypothesis that a management algorithm for asthma in pregnancy based on F(E)NO and symptoms would reduce asthma exacerbations...
  23. ncbi Antenatal risk factors for postnatal depression: a large prospective study
    Jeannette Milgrom
    Department of Psychology, School of Behavioural Science, University of Melbourne, Victoria, Australia
    J Affect Disord 108:147-57. 2008
    ....
  24. ncbi Maternal antenatal anxiety and children's behavioural/emotional problems at 4 years. Report from the Avon Longitudinal Study of Parents and Children
    Thomas G O'Connor
    Institute of Psychiatry, Denmark Hill, London
    Br J Psychiatry 180:502-8. 2002
    ..Animal experiments suggest that maternal stress and anxiety during pregnancy have long-term effects on the behaviour of the offspring...
  25. ncbi Sleep disturbances in depressed pregnant women and their newborns
    Tiffany Field
    Touch Research Institutes, University of Miami School of Medicine, United States
    Infant Behav Dev 30:127-33. 2007
    ..The newborns of the depressed mothers also had more sleep disturbances including less time in deep sleep and more time in indeterminate (disorganized) sleep, and they were more active and cried/fussed more...
  26. ncbi The influence of obesity and diabetes on the risk of cesarean delivery
    Hugh M Ehrenberg
    Case Western Reserve University School of Medicine, Department of Reproductive Biology, MetroHealth Medical Center, Cleveland, Ohio, USA
    Am J Obstet Gynecol 191:969-74. 2004
    ..To determine the influence of pregravid obesity and diabetes on cesarean delivery (CD) risk...
  27. ncbi Antenatal maternal anxiety and stress and the neurobehavioural development of the fetus and child: links and possible mechanisms. A review
    Bea R H Van den Bergh
    Department of Developmental Psychology, Catholic University of Leuven KULeuven, Tiensestraat 102, 3000 Leuven, Belgium
    Neurosci Biobehav Rev 29:237-58. 2005
    ..The magnitude of the long-term effects of antenatal maternal anxiety/stress on the child is substantial. Programs to reduce maternal stress in pregnancy are therefore warranted...
  28. ncbi Maternal lifestyle factors in pregnancy risk of attention deficit hyperactivity disorder and associated behaviors: review of the current evidence
    Karen Markussen Linnet
    Perinatal Epidemiological Research Unit, Department of Obstetrics and Gynecology, the Psychiatric Hospital for Children and Adolescent, Skejby, Denmark
    Am J Psychiatry 160:1028-40. 2003
    ....
  29. ncbi Delivery outcome after maternal use of antidepressant drugs in pregnancy: an update using Swedish data
    M Reis
    Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Linkoping, Sweden
    Psychol Med 40:1723-33. 2010
    ..Concerns have been expressed about possible adverse effects of the use of antidepressant medication during pregnancy, including risk for neonatal pathology and the presence of congenital malformations...
  30. ncbi Antenatal risk factors for postpartum depression: a synthesis of recent literature
    Emma Robertson
    University Health Network, Women s Health Program, 657 University Avenue, Toronto General Hospital, ML 2 004D, Toronto, MG5 2N2 Canada
    Gen Hosp Psychiatry 26:289-95. 2004
    ....
  31. ncbi Can gestational weight gain be modified by increasing physical activity and diet counseling? A meta-analysis of interventional trials
    Ina Streuling
    Division of Epidemiology, Institute of Social Pediatrics and Adolescent Medicine, Ludwig Maximilians University of Munich, Munich, Germany
    Am J Clin Nutr 92:678-87. 2010
    ..It is therefore of interest whether GWG can be modified by an intervention combining dietary counseling and physical activity...
  32. ncbi The epidemiology of smoking during pregnancy: smoking prevalence, maternal characteristics, and pregnancy outcomes
    Sven Cnattingius
    Karolinska Institutet, Stockholm, Sweden
    Nicotine Tob Res 6:S125-40. 2004
    ..Smoking during pregnancy will continue to be an important risk factor for maternal and fetal outcomes during pregnancy...
  33. pmc Reliability of self reported smoking status by pregnant women for estimating smoking prevalence: a retrospective, cross sectional study
    Deborah Shipton
    MRC Social and Public Health Sciences Unit, Glasgow G12 8RZ
    BMJ 339:b4347. 2009
    ..To determine what impact reliance on self reported smoking status during pregnancy has on both the accuracy of smoking prevalence figures and access to smoking cessation services for pregnant women in Scotland...
  34. ncbi Randomized controlled trial to prevent excessive weight gain in pregnant women
    B A Polley
    University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Int J Obes Relat Metab Disord 26:1494-502. 2002
    ..8-11.4 kg). A significant number of normal-weight women and an even greater proportion of overweight women exceed these guidelines, which increases postpartum weight retention and may contribute to the development of obesity...
  35. ncbi Preventing excessive weight gain during pregnancy through dietary and lifestyle counseling: a randomized controlled trial
    Shelly M Asbee
    Carolinas Medical Center, Charlotte, North Carolina, USA
    Obstet Gynecol 113:305-12. 2009
    ..To estimate whether an organized, consistent program of dietary and lifestyle counseling prevents excessive weight gain in pregnancy...
  36. ncbi The prevalence and impact of overweight and obesity in an Australian obstetric population
    Leonie K Callaway
    E Floor, Clinical Sciences Building, Royal Brisbane and Women s Hospital, Herston QLD 4029, Australia
    Med J Aust 184:56-9. 2006
    ..To assess the prevalence and impact of overweight and obesity in an Australian obstetric population...
  37. ncbi Trends in pre-pregnancy obesity in nine states, 1993-2003
    Shin Y Kim
    National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Division of Reproductive Health, 4770 Buford Highway NE, MS K 23, Atlanta, GA 30341, USA
    Obesity (Silver Spring) 15:986-93. 2007
    ..This study used a large population-based data source to examine trends, from 1993 through 2003, in the prevalence of pre-pregnancy obesity among women who delivered live infants...
  38. pmc Heavy smoking during pregnancy as a marker for other risk factors of adverse birth outcomes: a population-based study in British Columbia, Canada
    Anders C Erickson
    Division of Medical Sciences, University of Victoria, Medical Science Bld, Victoria, B C, Canada
    BMC Public Health 12:102. 2012
    ..Our goal was to determine whether number of cigarettes smoked could identify those in greatest need for comprehensive intervention programs to improve outcomes...
  39. pmc Pre-validation of the WHO organ dysfunction based criteria for identification of maternal near miss
    Jose G Cecatti
    Obstetric Unit, Department of Obstetrics and Gynecology, School of Medical Sciences, University of Campinas, Sao Paulo, Brazil
    Reprod Health 8:22. 2011
    ..To evaluate the performance of the WHO criteria for defining maternal near miss and identifying deaths among cases of severe maternal morbidity (SMM) admitted for intensive care...
  40. ncbi The Danish National Birth Cohort--its background, structure and aim
    J Olsen
    Danish Epidemiology Science Centre, Statens Serum Institut, Copenhagen, Denmark
    Scand J Public Health 29:300-7. 2001
    ..By August 2000. a total of 60,000 pregnant women had been recruited to the study. It is expected that a large number of gene-environmental hypotheses need to be based on case-control analyses within a cohort like this...
  41. ncbi High prevalence of type 2 diabetes and pre-diabetes in adult offspring of women with gestational diabetes mellitus or type 1 diabetes: the role of intrauterine hyperglycemia
    Tine D Clausen
    Department of Obstetrics, Copenhagen Center for Pregnant Women with Diabetes, Copenhagen University Hospital, Rigshospitalet, Denmark
    Diabetes Care 31:340-6. 2008
    ..We studied glucose tolerance in adult offspring of women with either gestational diabetes mellitus (GDM) or type 1 diabetes, taking the impact of both intrauterine hyperglycemia and genetic predisposition to type 2 diabetes into account...
  42. pmc Associations of gestational weight gain with maternal body mass index, waist circumference, and blood pressure measured 16 y after pregnancy: the Avon Longitudinal Study of Parents and Children (ALSPAC)
    Abigail Fraser
    MRC Centre for Causal Analyses in Translational Epidemiology and the School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
    Am J Clin Nutr 93:1285-92. 2011
    ..Little is known about associations of gestational weight gain (GWG) with long-term maternal health...
  43. pmc Cohort study of depressed mood during pregnancy and after childbirth
    J Evans
    Division of Psychiatry, University of Bristol, Bristol BS2 8DZ
    BMJ 323:257-60. 2001
    ..To follow mothers' mood through pregnancy and after childbirth and compare reported symptoms of depression at each stage...
  44. ncbi Silica and titanium dioxide nanoparticles cause pregnancy complications in mice
    Kohei Yamashita
    Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565 0871, Japan
    Nat Nanotechnol 6:321-8. 2011
    ..that silica and titanium dioxide nanoparticles with diameters of 70 nm and 35 nm, respectively, can cause pregnancy complications when injected intravenously into pregnant mice...
  45. ncbi Antithyroid drugs
    David S Cooper
    Division of Endocrinology, Sinai Hospital of Baltimore, The Johns Hopkins University School of Medicine, Baltimore 21215, USA
    N Engl J Med 352:905-17. 2005
  46. ncbi Obesity in pregnancy stimulates macrophage accumulation and inflammation in the placenta
    J C Challier
    University Paris 6, UPRESA 2796, France
    Placenta 29:274-81. 2008
    ..The resulting inflammatory milieu in which the fetus develops may have critical consequences for short and long term programming of obesity...
  47. ncbi Stillbirths: the way forward in high-income countries
    Vicki Flenady
    Mater Medical Research Institute, South Brisbane, QLD, Australia
    Lancet 377:1703-17. 2011
    ..Identification of ways to reduce maternal overweight and obesity is a high priority for high-income countries...
  48. ncbi The epidemiology of adverse pregnancy outcomes: an overview
    Michael S Kramer
    Department of Pediatrics, McGill University Faculty of Medicine, Montreal, Quebec, Canada
    J Nutr 133:1592S-1596S. 2003
    ..More progress is required, however, in understanding the etiology and prevention of preterm birth...
  49. ncbi Prevalence of maternal obesity in an urban center
    Hugh M Ehrenberg
    Department of Reproductive Biology, MetroHealth Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio 44109, USA
    Am J Obstet Gynecol 187:1189-93. 2002
    ..The purpose of this study was to evaluate the changing prevalence of maternal obesity in an urban center...
  50. pmc A meta-analysis of depression during pregnancy and the risk of preterm birth, low birth weight, and intrauterine growth restriction
    Nancy K Grote
    University of Washington, Seattle, 98105, USA
    Arch Gen Psychiatry 67:1012-24. 2010
    ..Maternal depressive symptoms during pregnancy have been reported in some, but not all, studies to be associated with an increased risk of preterm birth (PTB), low birth weight (LBW), and intrauterine growth restriction (IUGR)...
  51. ncbi Preventing excessive gestational weight gain: a systematic review of interventions
    H Skouteris
    Deakin University, Melbourne, Vic, Australia
    Obes Rev 11:757-68. 2010
    ..Consideration of psychological factors relevant to pregnancy, in addition to behavioural changes in relation to eating and physical activity, is suggested for future intervention studies...
  52. pmc Sleep deprivation during pregnancy and maternal and fetal outcomes: is there a relationship?
    Jen Jen Chang
    Department of Community Health in Epidemiology, Saint Louis University School of Public Health, 3545 Lafayette Ave, Suite 300, St Louis, MO 63104, USA
    Sleep Med Rev 14:107-14. 2010
    ..Future research with longitudinal study designs is needed to allow examination of the effect of sleep deprivation on adverse maternal and fetal outcomes...
  53. ncbi Antenatal interventions for overweight or obese pregnant women: a systematic review of randomised trials
    J M Dodd
    The University of Adelaide, Women s and Children s Hospital, North Adelaide, SA, Australia
    BJOG 117:1316-26. 2010
    ..Overweight and obesity during pregnancy is an increasing health problem...
  54. pmc Systematic review of clinical trials on dietary interventions to prevent excessive weight gain during pregnancy among normal weight, overweight and obese women
    Ida Tanentsapf
    Faculty of Health Sciences, Copenhagen University, Panum Instituttet, Copenhagen, Denmark
    BMC Pregnancy Childbirth 11:81. 2011
    ..The primary objective of this review was to evaluate the effect of dietary interventions for reducing GWG. The secondary objective was to examine the impact of these interventions on different child and maternal health outcomes...
  55. ncbi The effects of maternal body mass index on pregnancy outcome
    A S Khashan
    The Anu Research Centre, Department of Obstetrics and Gynaecology, Cork University Maternity Hospital, University College Cork, Wilton, Cork, Ireland
    Eur J Epidemiol 24:697-705. 2009
    ..Overweight and obese women have a higher risk of macrosomia and Caesarean delivery and lower risk of preterm delivery. The mechanism underlying this association is unclear and is worthy of further investigation...
  56. ncbi Rise in maternal mortality in the Netherlands
    J M Schutte
    Department of Obstetrics and Gynaecology, Isala Klinieken Zwolle, Dr van Heesweg 2, Zwolle, The Netherlands
    BJOG 117:399-406. 2010
    ..To assess causes, trends and substandard care factors in maternal mortality in the Netherlands. Design Confidential enquiry into the causes of maternal mortality...
  57. ncbi Neonatal outcomes after prenatal exposure to selective serotonin reuptake inhibitor antidepressants and maternal depression using population-based linked health data
    Tim F Oberlander
    Department of Pediatrics, Human Early Learning Partnership, Faculty of Graduate Studies, University of British Columbia, Vancouver
    Arch Gen Psychiatry 63:898-906. 2006
    ..Prenatal exposure to selective serotonin reuptake inhibitor (SSRI) antidepressants and maternal depression both alter neonatal health, and distinguishing the effects of each influence remains challenging...
  58. ncbi The short- and long-term implications of maternal obesity on the mother and her offspring
    P M Catalano
    Department of Reproductive Biology, Case Western Reserve University, MetroHealth Medical Center, Cleveland, OH 44109, USA
    BJOG 113:1126-33. 2006
    ..Additionally, we will review evidence of both short- and long-term effect of maternal obesity on the in utero environment as it relates to fetal growth, neonatal body composition and adolescent obesity...
  59. ncbi Developmental origins of obesity and the metabolic syndrome: the role of maternal obesity
    James Andrew Armitage
    Department of Anatomy and Developmental Biology, Monash University, Clayton, Vic, Australia
    Front Horm Res 36:73-84. 2008
    ..This chapter discusses the effects of maternal obesity on fetal development and birth outcomes as well as the manner in which DOHaD may contribute to the obesity epidemic...
  60. pmc Randomized trial of a behavioral intervention to prevent excessive gestational weight gain: the Fit for Delivery Study
    Suzanne Phelan
    Departments of Kinesiology, California Polytechnic State University, San Luis Obispo, 93407 0386, USA
    Am J Clin Nutr 93:772-9. 2011
    ....
  61. ncbi Pregnancy outcome in inflammatory bowel disease: prospective European case-control ECCO-EpiCom study, 2003-2006
    A Bortoli
    Rho Hospital, Rho MI, Italy
    Aliment Pharmacol Ther 34:724-34. 2011
    ..Inflammatory bowel disease (IBD) frequently affects women during their reproductive years. Pregnancy outcome in women with IBD is well described, particularly in retrospective studies...
  62. ncbi Placental weight and efficiency in relation to maternal body mass index and the risk of pregnancy complications in women delivering singleton babies
    J M Wallace
    Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen AB21 9SB, UK
    Placenta 33:611-8. 2012
    Herein we report placental weight and efficiency in relation to maternal BMI and the risk of pregnancy complications in 55,105 pregnancies...
  63. ncbi Predicting preschooler obesity at birth: the role of maternal obesity in early pregnancy
    Robert C Whitaker
    Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Pediatrics 114:e29-36. 2004
    ..The objective of this study was to determine whether children whose mothers were obese in early pregnancy were more likely to be obese at 2 to 4 years of age...
  64. ncbi The influence of obesity and diabetes on the prevalence of macrosomia
    Hugh M Ehrenberg
    Case Western Reserve University School of Medicine, Department of Reproductive Biology, MetroHealth Medical Center, Cleveland, Ohio, USA
    Am J Obstet Gynecol 191:964-8. 2004
    ..This study was undertaken to determine the relative contribution of abnormal pregravid maternal body habitus and diabetes on the prevalence of large-for-gestational-age infants...
  65. pmc Reduction of severe acute maternal morbidity and maternal mortality in Thyolo District, Malawi: the impact of obstetric audit
    Thomas van den Akker
    Thyolo District Health Office, Ministry of Health, Thyolo, Malawi
    PLoS ONE 6:e20776. 2011
    ....
  66. pmc The LiP (Lifestyle in Pregnancy) study: a randomized controlled trial of lifestyle intervention in 360 obese pregnant women
    Christina A Vinter
    Department of Gynecology and Obstetrics, Odense University Hospital, Odense, Denmark
    Diabetes Care 34:2502-7. 2011
    ..To study the effects of lifestyle intervention on gestational weight gain (GWG) and obstetric outcomes...
  67. ncbi Selective serotonin reuptake inhibitors during pregnancy and risk of persistent pulmonary hypertension in the newborn: population based cohort study from the five Nordic countries
    Helle Kieler
    Centre for Pharmacoepidemiology, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, T2, SE 171 76 Stockholm, Sweden
    BMJ 344:d8012. 2012
    ..To assess whether maternal use of selective serotonin reuptake inhibitors (SSRIs) increases the risk of persistent pulmonary hypertension in the newborn, and whether such an effect might differ between specific SSRIs...
  68. ncbi Folate and human reproduction
    Tsunenobu Tamura
    Department of Nutrition Sciences, University of Alabama at Birmingham, AL 35294, USA
    Am J Clin Nutr 83:993-1016. 2006
    ....
  69. pmc Using audit to enhance quality of maternity care in resource limited countries: lessons learnt from rural Tanzania
    Angelo S Nyamtema
    Saint Francis Designated District Hospital, Ifakara, Tanzania
    BMC Pregnancy Childbirth 11:94. 2011
    ..Maternal mortality and morbidity audit was established at Saint Francis Designated District Hospital (SFDDH) in rural Tanzania in order to generate information upon which to base interventions...
  70. ncbi Effect of lifestyle intervention on dietary habits, physical activity, and gestational weight gain in obese pregnant women: a randomized controlled trial
    Isabelle Guelinckx
    Department of Nutrition Public Health Medicine, LFoRCe, Catholic University Leuven, Leuven, Belgium
    Am J Clin Nutr 91:373-80. 2010
    ..Maternal obesity and excessive gestational weight gain (GWG) are major short- and long-term risk factors for maternal and fetal complications...
  71. pmc Lipotoxicity in obese pregnancy and its potential role in adverse pregnancy outcome and obesity in the offspring
    Eleanor Jarvie
    Reproductive and Maternal Medicine, Faculty of Medicine, University of Glasgow, Glasgow, U K
    Clin Sci (Lond) 119:123-9. 2010
    ..The combination of excess/altered lipid nutrient supply, suboptimal in utero metabolic environment and alterations in placental gene expression, inflammation and metabolism may also induce obesity in the offspring...
  72. pmc Maternal activating KIRs protect against human reproductive failure mediated by fetal HLA-C2
    Susan E Hiby
    Department of Pathology, University of Cambridge, Cambridge, UK
    J Clin Invest 120:4102-10. 2010
    ..These findings highlight the complexity and central importance of specific combinations of activating KIR and HLA-C in maternal-fetal immune interactions that determine reproductive success...
  73. ncbi Selective serotonin-reuptake inhibitors and risk of persistent pulmonary hypertension of the newborn
    Christina D Chambers
    Department of Pediatrics, University of California, San Diego, La Jolla, CA 92103, USA
    N Engl J Med 354:579-87. 2006
    ..We performed a case-control study to assess whether PPHN is associated with exposure to SSRIs during late pregnancy...
  74. ncbi Risk factors for small for gestational age infants
    Lesley McCowan
    Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, University of Auckland, Private Bag 92019 Auckland, New Zealand
    Best Pract Res Clin Obstet Gynaecol 23:779-93. 2009
    ..Future studies need to investigate risk factors for babies SGA by customised centiles as these babies have greater morbidity and mortality than babies defined as SGA by population centiles...
  75. ncbi Intrahepatic cholestasis of pregnancy: Amelioration of pruritus by UDCA is associated with decreased progesterone disulphates in urine
    Anna Glantz
    Department of Obstetrics and Gynaecology, Sahlgrenska University Hospital East, Gothenburg, Sweden
    Hepatology 47:544-51. 2008
    ..In contrast, in patients randomized to dexamethasone or placebo, no changes in steroid metabolites or pruritus scores were observed...
  76. ncbi Near misses: a useful adjunct to maternal death enquiries
    R C Pattinson
    MRC Maternal and Infant Health Care Strategies Research Unit, University of Pretoria, South Africa
    Br Med Bull 67:231-43. 2003
    ..However, areas with similar health care facilities, medical records and personnel should be able to agree on suitable criteria, making their incorporation into maternal death enquiries feasible...
  77. ncbi Effects of exposure to selective serotonin reuptake inhibitors during pregnancy on serotonergic symptoms in newborns and cord blood monoamine and prolactin concentrations
    Kari Laine
    Department of Pharmacology and Clinical Pharmacology, University of Turku and Turku University Central Hospital, Turku, Finland
    Arch Gen Psychiatry 60:720-6. 2003
    ..We aimed to investigate the perinatal sequelae of infants exposed to SSRIs during their fetal life and the relationship of these symptoms to the cord blood monoamine and prolactin concentrations...
  78. pmc Impact of maternal body mass index on neonatal outcome
    P Kalk
    Department of Pharmacolcgy and Toxicology, Charite, Hessische Str 3 4, 10115 Berlin, Germany
    Eur J Med Res 14:216-22. 2009
    ..An increased maternal BMI is known to be associated with admission of the newborn to a neonatal care unit. The reasons and impact of this admission on fetal outcome, however, are unknown so far...
  79. ncbi Obesity and pregnancy--the propagation of a viscous cycle?
    Patrick M Catalano
    J Clin Endocrinol Metab 88:3505-6. 2003
  80. ncbi Vitamin D deficiency and insufficiency is common during pregnancy
    Donna D Johnson
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, South Carolina 29425 0619, USA
    Am J Perinatol 28:7-12. 2011
    ..This study demonstrates widespread vitamin D deficiency and insufficiency in pregnant females living at a southern latitude. African-Americans are at greatest risk...
  81. ncbi Pregnancy-related mortality surveillance--United States, 1991--1999
    Jeani Chang
    Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, USA
    MMWR Surveill Summ 52:1-8. 2003
    ..3 maternal deaths per 100,000 live births was not achieved during the twentieth century; substantial improvements are needed to meet the same objective for Healthy People 2010...
  82. ncbi Sleep quality and depression during pregnancy: a prospective study
    Helen Skouteris
    School of Psychology, Deakin University, Australia
    J Sleep Res 17:217-20. 2008
    ..Given that depressive symptomatology can lead to major depression and given the prevalence of pre- and postnatal depression, our findings suggest that screening for sleep problems during pregnancy may be of clinical significance...
  83. ncbi Maternal nutrition and fetal development
    Guoyao Wu
    Department of Animal Science, Texas A and M University, Health Science Center, College Station, TX 77843, USA
    J Nutr 134:2169-72. 2004
    ..Promoting optimal nutrition will not only ensure optimal fetal development, but will also reduce the risk of chronic diseases in adults...
  84. ncbi Outcome of pregnancy in a woman with an increased body mass index
    T S Usha Kiran
    Department of Obstetrics and Gynaecology, University Hospital of Wales and Llandough Hospital Trust, Cardiff, UK
    BJOG 112:768-72. 2005
    ..To show the increased risk of adverse outcomes in labour and fetomaternal morbidity in obese women (BMI > 30)...
  85. ncbi The continuum of maternal morbidity and mortality: factors associated with severity
    Stacie E Geller
    Department of Obstetrics and Gynecology, College of Medicine, University of Illinois at Chicago, 60612, USA
    Am J Obstet Gynecol 191:939-44. 2004
    ..The goal of this study was to examine whether sociodemographic, clinical, and other service-related factors, as well as preventability issues affect a woman's progression along the continuum of morbidity and mortality...
  86. ncbi Lifestyle modification program decreases pregnancy weight gain in obese women
    Taraneh Shirazian
    Department of Obstetrics, Gynecology and Reproductive Sciences, Mount Sinai School of Medicine, New York, New York 10029, USA
    Am J Perinatol 27:411-4. 2010
    ..This study suggests an effective method of reducing prenatal weight gain in the obese population. This type of comprehensive intervention could be an important, cost-effective risk-reduction strategy...
  87. pmc Asthma exacerbations during pregnancy: incidence and association with adverse pregnancy outcomes
    V E Murphy
    Department of Respiratory and Sleep Medicine, John Hunter Hospital, Locked Bag 1, Hunter Region Mail Centre, Newcastle, New South Wales 2310, Australia
    Thorax 61:169-76. 2006
    ..Pregnant women may be less likely to receive oral steroids for the emergency management of asthma. The effective management and prevention of asthma exacerbations during pregnancy is important for the health of both the mother and fetus...
  88. ncbi Maternal and perinatal health outcomes by body mass index category
    Jodie M Dodd
    The University of Adelaide, Discipline of Obstetrics and Gynaecology Epidemiology Branch, SA Health, South Australia, Australia
    Aust N Z J Obstet Gynaecol 51:136-40. 2011
    ..To determine the effect of increasing maternal body mass index (BMI) during pregnancy on maternal and infant health outcomes...
  89. ncbi Maternal overweight and obesity and the risk of congenital anomalies: a systematic review and meta-analysis
    Katherine J Stothard
    Institute of Health and Society, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom NE2 4HH
    JAMA 301:636-50. 2009
    ..Evidence suggests an association between maternal obesity and some congenital anomalies...
  90. ncbi Obesity and pregnancy: complications and cost
    F Galtier-Dereure
    Service d endocrinologie, Hopital Lapeyronie, CHU Montpellier, France
    Am J Clin Nutr 71:1242S-8S. 2000
    ..Preconception counseling, careful prenatal management, tight monitoring of weight gain, and long-term follow-up could minimize the social and economic consequences of pregnancies in overweight women...
  91. pmc Prenatal risk factors for autism: comprehensive meta-analysis
    Hannah Gardener
    Department of Neurology, University of Miami Miller School of Medicine, Post Office Box 016960 M712, Miami, FL 33101, USA
    Br J Psychiatry 195:7-14. 2009
    ..The aetiology of autism is unknown, although prenatal exposures have been the focus of epidemiological research for over 40 years...
  92. ncbi Socioeconomic disparities in adverse birth outcomes: a systematic review
    Philip Blumenshine
    Center on Social Disparities in Health, Department of Family and Community Medicine, University of California San Francisco, San Francisco, California 94118, USA
    Am J Prev Med 39:263-72. 2010
    ....
  93. ncbi Subclinical hypothyroidism and pregnancy outcomes
    Brian M Casey
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9032, USA
    Obstet Gynecol 105:239-45. 2005
    Clinical thyroid dysfunction has been associated with pregnancy complications such as hypertension, preterm birth, low birth weight, placental abruption, and fetal death...
  94. ncbi Maternal obesity at conception programs obesity in the offspring
    Kartik Shankar
    Arkansas Children s Nutrition Center, 1212 Marshall Street, Little Rock, AR 72202, USA
    Am J Physiol Regul Integr Comp Physiol 294:R528-38. 2008
    ..Our data suggest that maternal obesity at conception leads to fetal programming of offspring, which could result in obesity in later life...
  95. ncbi Prenatal exposure to the Dutch famine and disease in later life: an overview
    Rebecca C Painter
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Reprod Toxicol 20:345-52. 2005
    ..Future research should shed more light upon the underlying pathophysiology of the far-reaching effects of prenatal exposure to famine...
  96. pmc Preventable maternal mortality: geographic/rural-urban differences and associated factors from the population-based Maternal Mortality Surveillance System in China
    Juan Liang
    National Office for Maternal and Child Health Surveillance, West China Second University Hospital, Sichuan University, No 17 Section 3 Ren Min Nan Lu, Chengdu, Sichuan, China
    BMC Public Health 11:243. 2011
    ..This study examined the geographic and rural-urban differences, time trends and related factors in preventable maternal deaths in China during 1996-2005, with the aim of providing reliable evidence for effective interventions...
  97. ncbi Gestational weight gain and pregnancy outcomes in obese women: how much is enough?
    Deborah W Kiel
    Department of Community Health, Saint Louis University, St Louis, Missouri, USA
    Obstet Gynecol 110:752-8. 2007
    ..To examine the effect of gestational weight change on pregnancy outcomes in obese women...
  98. ncbi Vitamin D supplementation during pregnancy: safety considerations in the design and interpretation of clinical trials
    D E Roth
    Division of Pediatric Medicine, The Hospital for Sick Children, Toronto, ON, Canada
    J Perinatol 31:449-59. 2011
    ..Antenatal vitamin D supplementation trials should incorporate a range of methods for objectively establishing maternal and fetal safety, and aim to identify the lowest doses of vitamin D required to achieve target outcomes...
  99. ncbi Outcomes of prenatal antidepressant exposure
    Gregory E Simon
    Center for Health Studies, Group Health Cooperative, 1730 Minor Avenue 1600, Seattle, WA 98101, USA
    Am J Psychiatry 159:2055-61. 2002
    ..This study evaluated the effects of prenatal antidepressant exposure on perinatal outcomes, congenital malformations, and early growth and development...
  100. pmc Systematic review of the magnitude and case fatality ratio for severe maternal morbidity in sub-Saharan Africa between 1995 and 2010
    Dan K Kaye
    Department of Obstetrics and Gynecology, School of Medicine, Makerere University College of Health Sciences, PO Box 7072, Kampala, Uganda
    BMC Pregnancy Childbirth 11:65. 2011
    ..We assessed the prevalence/incidence of maternal near miss, maternal mortality and case fatality ratio through systematic review of studies on severe maternal morbidity in sub-Saharan Africa...
  101. ncbi Pregnancy and safety outcomes in women vaccinated with an AS03-adjuvanted split virion H1N1 (2009) pandemic influenza vaccine during pregnancy: a prospective cohort study
    Fernanda Tavares
    Global Vaccine Development, GlaxoSmithKline GSK Biologicals, Parc de la Noire Epine, Avenue Fleming 20, 1300 Wavre, Belgium
    Vaccine 29:6358-65. 2011
    ....

Research Grants64

  1. Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of Periodontitis
    JUSTIN RODNEY SAVAGE; Fiscal Year: 2011
    ..substantially increase the risk of systemic conditions, including cardiovascular and renal diseases, and pregnancy complications. Periodontal disease is exacerbated in diabetics and smokers due to increased exposure to advanced ..
  2. Predictors of Pregnancy Outcome in SLE and APS
    Jane E Salmon; Fiscal Year: 2012
    b>Pregnancy complications in women with the antiphospholipid syndrome (APS) and/or SLE include recurrent miscarriage, preeclampsia, placental insufficiency, and intrauterine growth restriction (IUGR)...
  3. Apoptosis and Trophoblast Fusion
    NEAL STEWART ROTE; Fiscal Year: 2010
    Common pregnancy complications, such as intrauterine growth restriction (IUGR) and miscarriage, are strongly associated with abnormal development of the placenta...
  4. DHA, Inflammation, and Insulin Sensitivity in Obese Pregnant Women
    Debra Krummel; Fiscal Year: 2009
    ..is currently available for this common condition and obesity in pregnancy increases the risk for pregnancy complications and predisposes both the woman and her child to develop diabetes and cardiovascular disease later in life...
  5. The role of NLRP7 and related genes in hydatidiform moles and reproductive failur
    Ignatia Van den Veyver; Fiscal Year: 2009
    ..moles (a severe pregnancy complication with hyperplastic placenta and absent fetus), and sometimes other pregnancy complications. Because genetic imprinting is abnormal in these hydatidiform moles, we propose to determine whether this ..
  6. Treatment of Hyperandrogenism vs. Insulin Resistance in Infertile PCOS Women
    Richard S Legro; Fiscal Year: 2012
    ..most common cause of anovulatory infertility among women, and women with PCOS are at increased risk for pregnancy complications such as gestational diabetes and pre-eclampsia...
  7. Role of the Renin-Angiotensin system in placental insufficiency
    Eugenia Mata-Greenwood; Fiscal Year: 2013
    ..Human studies have revealed that the uteroplacental RAS becomes dysregulated in pregnancy complications like recurrent miscarriage (fetal loss), intrauterine growth restriction (IUGR) and pre-eclampsia (PE)...
  8. Weight management for improved pregnancy outcomes
    Victor J Stevens; Fiscal Year: 2012
    ..of obstetrics patients now have levels of obesity which dramatically increase their risk of serious pregnancy complications. These complications include increased risk of miscarriage, stillbirth, having a fetus that is too large ..
  9. Eunice Kennedy Shriver NICHD Maternal Fetal Medicine Units Network
    Edward K Chien; Fiscal Year: 2013
    ..The impact of pregnancy complications can be devastating, affecting decades of life...
  10. Long Term Implications of Preeclampsia: Role of Obesity vs sFlt-1 Overexpression
    Egle Bytautiene; Fiscal Year: 2009
    ..Therefore, we hypothesize that pregnancy complications superimposed on CVD risk factors, such as obesity, lead to the development of long-term adverse changes ..
  11. Cooperative Multicenter Maternal Fetal Medicine Units Networks
    John M Thorp; Fiscal Year: 2013
    ..of which are high-risk by virtue of maternal co-morbidities, including substance abuse, fetal anomalies, pregnancy complications, or preterm birth risk profile, including multiple gestations...
  12. Role of Maternal Platelets in the Placenta and Pregnancy Complications
    Rashmi Sood; Fiscal Year: 2013
    ..These are much-needed investigations into platelet and coagulation activities at the feto-maternal interface with direct significance for pregnancy disorders. ..
  13. Pregnancy complications, future cardiovascular disease risk factors and cardiovas
    NISHA INDRAVADAN PARIKH; Fiscal Year: 2013
    ....
  14. Evolved placental response to hypoxa
    Stacy Zamudio; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Placental hypoxia contributes to major pregnancy complications such as intrauterine growth restriction (IUGR) and preeclampsia (PE)...
  15. Regulatory Costimulatory Pathways &Fetomaternal Tolerance
    Indira Guleria; Fiscal Year: 2012
    ..Furthermore, a number of studies associate some pregnancy complications with abnormal maternal immune responses...
  16. STUDIES OF UTEROPLACENTAL CIRCULATION
    CHARLES RICHARD ROSENFELD; Fiscal Year: 2013
    ..be compromised and associated with increased fetal-neonatal mortality and morbidity, preterm birth and pregnancy complications resulting in impaired fetal-neonatal well-being...
  17. Immune Gene Regulation in Human Trophoblast Cells
    Shawn P Murphy; Fiscal Year: 2012
    ..potentially deleterious responses to IFN-3, and how aberrant cytokine signaling in TBCs may lead to pregnancy complications. This work also has important implications for tumor immunity, for loss of responsiveness to IFN-3 by ..
  18. Hypoxia and Aberrant Uterine Vascular Adaptation in Pregnancy
    Lubo Zhang; Fiscal Year: 2013
    ..mechanisms underlying aberrant uteroplacental circulation and hence improve our understanding of the pregnancy complications associated with hypoxia, but also provide exciting novel insights into the epigenetic mechanisms ..
  19. Understanding the genetic risk underlying racial disparities in uterine fibroids
    Digna R Velez Edwards; Fiscal Year: 2013
    ..negatively impact reproductive health causing heavy and painful menses, pelvic pain and pressure, pregnancy complications, and interventions including myomectomy and hysterectomy...
  20. ACE2 Deficiency: A new model of maternal and fetal growth restriction.
    Liliya M Yamaleyeva; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Pregnancy complications are one of the leading problems in women's health. Maternal weight is an important determinant of optimal fetal development...
  21. Modeling human trophoblast stem cells using iPS cells derived from molar placenta
    Mana M Parast; Fiscal Year: 2013
    ..during early embryonic life is thought to lead to chronic feto-placental hypoxia and result in pregnancy complications associated with both maternal and fetal morbidity and mortality, such as preeclampsia and fetal growth ..
  22. Epigenetic regulation of decidual inflammation
    Adrian Erlebacher; Fiscal Year: 2013
    ..gene silencing in human pregnancy, and for considering its potential significance with regards to human pregnancy complications. Aim II, which constitutes the bulk of the proposal, employs fresh first trimester decidual specimens and ..
  23. Medicaid Expansion in Oregon: Access and Health Outcomes for Women and Infants
    Jeff Luck; Fiscal Year: 2013
    ..women and infants enrolled in Medicaid; general health behaviors, risks, and outcomes for these women;and pregnancy complications and poor birth outcomes...
  24. MOTOR-Maternal Oral Therapy to Reduce Obstetric Risk
    STEVEN NMN OFFENBACHER; Fiscal Year: 2010
    Recent studies have confirmed that there is an association between maternal periodontal disease and pregnancy complications that result in premature delivery [e.g. gestational age (GA)<37 weeks: adjusted odds ratio 2.1(CI95%:1.12, 4...
  25. Immune responses to infection at the maternal-fetal interface
    Gabrielle A Rizzuto; Fiscal Year: 2013
    ..LM infection during pregnancy in humans and other mammals leads to pregnancy complications such as preterm labor...
  26. A Novel Model for Assessing the Effects of BPA Exposures on Human Placentation
    Susan J Fisher; Fiscal Year: 2013
    ..Studying the normal process has revealed the pathological changes that contribute to pregnancy complications, such as preeclampsia, and the effects of xenobiotics that are associated with impaired growth, such as ..
  27. Prenatal Smoking, Maternal &Fetal Genetic Variation &Risk of Preeclampsia
    Stephanie M Engel; Fiscal Year: 2012
    ..Although maternal smoking increases the risk of several major pregnancy complications, it paradoxically decreases the risk of preeclampsia by an estimated 30 per cent, which may provide ..
  28. Long-Term Burden of Maternal Cardiovascular Risk Factors and Birth Outcomes
    EMILY WHEELER HARVILLE; Fiscal Year: 2013
    ..relationship between cardiovascular disease (CVD) risk factors across the lifespan, birth outcomes, and pregnancy complications. Our specific aims are 1...
  29. Role of ICOS-B7h Regulatory Costimulatory Pathway in Fetomaternal Tolerance
    Indira Guleria; Fiscal Year: 2010
    ..Furthermore, a number of studies associate some pregnancy complications with abnormal maternal immune responses...
  30. Innate Immune Responses of Trophoblasts in Pregnancy
    Vikki M Abrahams; Fiscal Year: 2013
    ..Since there are no good biomarkers or preventative strategies, infection-associated pregnancy complications represent an important clinical problem...
  31. Molecular Mechanisms Regulating Placental Nutrient Transporters
    Thomas Jansson; Fiscal Year: 2013
    ..placental nutrient transport and fetal growth, which will increase our understanding of how important pregnancy complications develop...
  32. A longitudinal study of loss of imprinting in the placenta
    Ronald Wapner; Fiscal Year: 2012
    ..NuMOM2B Trial to monitor LOI in placenta samples from first trimester CVS to birth and determine which LOI patterns in the first trimester lead to normal pregnancy outcomes and which patterns are predictive of pregnancy complications.
  33. Unique Anti-microbial Rinse to Reduce Oral Inflammation
    Charles J Gauntt; Fiscal Year: 2012
    ..cardiovascular disease (atherosclerosis, myocardial infarction, and stroke), and diabetes, as well as for pregnancy complications such as preterm birth...
  34. Adverse Outcomes in Nulliparous Pregnancies: The Ohio Collaborative
    Brian M Mercer; Fiscal Year: 2013
    ..the clinical, ultrasound, patho- physiologic and biologic markers needed identify those at-risk for pregnancy complications including preterm birth, so that monitoring and interventions can be focused to prevent or reduce the ..
  35. Reducing Cardiovascular Risk in Women with Hypertension or Diabetes in Pregnancy
    WENDY LYNET BENNETT; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Women with recent pregnancy complications, such as gestational diabetes mellitus (GDM) and hypertensive disorders in pregnancy (HDP), have an increased risk of developing cardiovascular disease (CVD)...
  36. Maternal-Offspring Metabolics: Family Intervention Trial (MOMFIT)
    LINDA VERNER VAN HORN; Fiscal Year: 2012
    ..Preventing excessive GWG could reduce pregnancy complications and improve long term health of women and their offspring...
  37. Maternal Genetic Variation and Risk of Adverse Pregnancy Outcomes
    Stephanie M Engel; Fiscal Year: 2010
    ..Preterm birth, small-for-gestational age (SGA) and pregnancy induced hypertension (PIH) are major pregnancy complications that impact the health of the mother and the child, often resulting in admission to the neonatal ..
  38. Role of Host Cells in Invasive Listeriosis
    Anna Bakardjiev; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Infections are a leading cause of pregnancy complications;yet, little is known about their underlying molecular and cellular mechanisms...
  39. Sirt1-PPARgamma signaling in placental development and fetal growth disorders
    Mana M Parast; Fiscal Year: 2013
    ..provided by applicant): Fetal growth disorders (both growth restriction and overgrowth) are common pregnancy complications, which carry an increased risk of adverse outcomes in the perinatal period and an increased risk of ..
  40. DEVELOPMENT OF LIGANDS FOR NICOTINIC RECEPTORS
    Frank Ivy Carroll; Fiscal Year: 2012
    ..with cancer, cardiovascular disease, cerebral vascular disease, chronic obstructive airway disease, and pregnancy complications, development of new and better pharmacotherapies to treat smokers would be tremendously beneficial to ..
  41. Late Effects of Treatment in Wilms Tumor Survivors and Offspring
    Wendy M Leisenring; Fiscal Year: 2013
    ..The study will estimate rates of ovarian failure in female patients and rates of live birth and risks of pregnancy complications in partners of male patients...
  42. Translational Bioinformatics for Human Developmental Genomics
    Donna Slonim; Fiscal Year: 2012
    Fetal developmental disorders and pregnancy complications pose critical public health challenges. Yet our ability to monitor prenatal development and neonatal health has not fully entered the era of genomic medicine...
  43. Host-pathogen Interactions during Vertical Transmission of Listeria monocytogenes
    HOLLY ANN MORRISON; Fiscal Year: 2013
    ..Remarkably, our understanding of how pathogens infect the placenta and lead to pregnancy complications remains extremely limited, largely due to the inherent intractability of this tissue...
  44. Communication on Illicit Drug and/or Alcohol Use in Obstetrics
    Judy C Chang; Fiscal Year: 2013
    ..billion to address various needs of drug-exposed babies and approximately $300 million a year addressing pregnancy complications associated with smoking...
  45. Dissecting the Genetic Etiology of Preterm Birth in Nulliparous Women
    DAVID MICHAEL HAAS; Fiscal Year: 2013
    ..It is imperative to develop new strategies to understand this and other pregnancy complications to better prevent, diagnose, and treat conditions such as preterm birth...
  46. Fully automating uterine electromyography (EMG) for real-time obstetric applicati
    JACK MCCRARY; Fiscal Year: 2013
    ..e. "TOCO"), with a truly objective device capable of measuring the onset and progress of labor, as well as providing a tool to develop better treatment strategies for pregnancy complications.
  47. F.nucleatum in Amniotic Fluid Infection
    Yiping Han; Fiscal Year: 2004
    ..Preliminary studies revealed that haematogenous infection of. F nucleatum induced pregnancy complications in mice...
  48. Eunice Kennedy Shriver NICHD Maternal Fetal Medicine Units Network (U10)
    Brian M Casey; Fiscal Year: 2013
    ..b>Pregnancy complications of particular interest to the MFMU Network, for example, preterm birth and preeclampsia, are well ..
  49. Pregnancy Outcomes in Polycystic Ovary Syndrome
    Joan Lo; Fiscal Year: 2009
    ..In women with PCOS who do get pregnant, limited data suggest there may be a higher incidence of pregnancy complications, including gestational diabetes and hypertensive disorders...
  50. Training in Reproductive, Perinatal Pediatric Epidemiology
    CAROLYN DAWSON DREWS-BOTSCH; Fiscal Year: 2013
    ..in reducing major morbiditiy and mortality associated with gynecologic infertility, unintended pregnancy, pregnancy complications, preterm delivery, developmental disabilities, and congenital defects...
  51. Mechanisms of aPL antibody-induced pregnancy loss
    Jane Salmon; Fiscal Year: 2005
    ..b>Pregnancy complications in women with APS include fetal death, preeclampsia, and intrauterine growth restriction (IUGR)...
  52. Mechanism of aPL antibody-induced Pregnancy loss
    Jane E Salmon; Fiscal Year: 2010
    ..b>Pregnancy complications in women with APS include fetal death, preeclampsia, and intrauterine growth restriction (IUGR)...
  53. Hormone markers during pregnancy and ovarian concer risk
    Sven Cnattingius; Fiscal Year: 2005
    ..We plan to retrieve information about maternal characteristics, pregnancy complications, placental weight, birth characteristics for all births to these women, and women will be followed up in ..
  54. Eating Disorders and Pregnancy Outcome in 100,000 Births
    Cynthia Bulik; Fiscal Year: 2007
    ..Two related and growing bodies of research suggest that women with eating disorders (EDs) experience pregnancy complications more frequently than healthy women, and individuals with EDs are more likely than healthy individuals to ..
  55. Rapid, Inexpensive Microchip Assay for Homocysteine
    Dale Willard; Fiscal Year: 2009
    ..a sensitive marker for folate and colalamin (vitamin B12) deficiency, with implications to birth defects, pregnancy complications, psychiatric disorders, and cognitive impairment in the elderly...
  56. Mechanism of F. nucleatum in intrauterine infection
    Yiping Han; Fiscal Year: 2013
    Intrauterine infection is a major cause of pregnancy complications. Fusobacterium nucleatum (Fn), a gram-negative oral anaerobe, is one of the most prevalent species in intrauterine infection...
  57. A Model Statewide Trial to Detect and Treat Maternal Hypothyroidism in Pregnancy
    James Haddow; Fiscal Year: 2009
    ..0 mU/L) retain 95% treated women to end of pregnancy, and 90% for up to 1 year postpartum obtain pregnancy complications and birth outcomes for the entire cohort (Vital Records) Data will be collected on participation by ..
  58. COMPARISON OF CHORION VILLUS SAMPLING AND AMNIOCENTESIS
    David Ledbetter; Fiscal Year: 1990
    ..CVS: 1) What is the risk? Specifically, is CVS associated with an increased rate of spontaneous abortion, pregnancy complications, or physical or developmental risk to the fetus? 2) Is the laboratory data from CVS accurate? The study ..
  59. Mechanisms of Arsenic Toxicity in Vascular Development
    J Douglas Coffin; Fiscal Year: 2003
    ..Exposure to arsenic is linked to several developmental defects in the nervous system and limbs, pregnancy complications and miscarriage...
  60. DESIGN OF A MULTI-USE DIABETES REGISTRY
    BARBARA COHN; Fiscal Year: 1992
    ..diabetic women of reproductive age for preconception care and improved prenatal care which can reduce the pregnancy complications known to occur among diabetics...
  61. Effects of Pregnancy on Adolescent Growth and Health
    Patricia Crawford; Fiscal Year: 2004
    ..pregnancy medical records (gestational age and weight gain, maternal and infant health outcomes, and pregnancy complications)...
  62. ANGIOTENSINOGEN VARIANTS AND ADVERSE PREGNANCY OUTCOMES
    Kenneth Ward; Fiscal Year: 2002
    ..Failed volume expansion and failed or abnormal physiologic change are associated with a variety of common pregnancy complications, including preeclampsia, intrauterine growth retardation (IUGR), and preterm labor...
  63. International Conference on Tobacco Induced Diseases
    Denis Kinane; Fiscal Year: 2004
    ..COPD; 10. Diabetes - animal models of pancreatic dysfunction; 11. Periodontitis;12. Heart disease;13. Pregnancy complications; 14. Sudden Infant Death Syndrome (Cot Death); 15. Birth Defects Treatment: 15...
  64. COMPARISON OF CHORION VILLUS SAMPLING AND AMNIOCENTESIS
    Joe Simpson; Fiscal Year: 1990
    ..Ultrasound will be performed one week thereafter, and again at 16 weeks. Pregnancy complications will be recorded at 4-week intervals throughout gestation...