retinopathy of prematurity

Summary

Summary: A bilateral retinopathy occurring in premature infants treated with excessively high concentrations of oxygen, characterized by vascular dilatation, proliferation, and tortuosity, edema, and retinal detachment, with ultimate conversion of the retina into a fibrous mass that can be seen as a dense retrolental membrane. Usually growth of the eye is arrested and may result in microophthalmia, and blindness may occur. (Dorland, 27th ed)

Top Publications

  1. ncbi Can changes in clinical practice decrease the incidence of severe retinopathy of prematurity in very low birth weight infants?
    Lily C Chow
    Division of Neonatology, Department of Pediatrics, Cedars Sinai Medical Center and UCLA School of Medicine, Los Angeles, California, USA
    Pediatrics 111:339-45. 2003
  2. pmc Vascular endothelial growth factor in eye disease
    J S Penn
    Vanderbilt University School of Medicine, Nashville, TN, USA
    Prog Retin Eye Res 27:331-71. 2008
  3. pmc Target ranges of oxygen saturation in extremely preterm infants
    Waldemar A Carlo
    N Engl J Med 362:1959-69. 2010
  4. ncbi Longitudinal postnatal weight measurements for the prediction of retinopathy of prematurity
    Carolyn Wu
    Department of Ophthalmology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Arch Ophthalmol 128:443-7. 2010
  5. ncbi Perinatal growth characteristics and associated risk of developing threshold retinopathy of prematurity
    Karel Allegaert
    Neonatal Intensive Care Unit, Department of Pediatrics, University Hospitals, Leuven, Belgium
    J AAPOS 7:34-7. 2003
  6. ncbi Retinopathy of prematurity
    Jing Chen
    Department of Ophthalmology, Harvard Medical School and Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    Angiogenesis 10:133-40. 2007
  7. pmc Efficacy of intravitreal bevacizumab for stage 3+ retinopathy of prematurity
    Helen A Mintz-Hittner
    Department of Ophthalmology and Visual Science, University of Texas Health Science Center at Houston Medical School, Houston, USA
    N Engl J Med 364:603-15. 2011
  8. ncbi Serum concentrations of bevacizumab (avastin) and vascular endothelial growth factor in infants with retinopathy of prematurity
    Tatsuhiko Sato
    Department of Applied Visual Science, Osaka University Graduate School of Medicine, Suita, Japan
    Am J Ophthalmol 153:327-333.e1. 2012
  9. pmc A clinical prediction model to stratify retinopathy of prematurity risk using postnatal weight gain
    Gil Binenbaum
    Division of Ophthalmology, Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, 9 Main, Philadelphia, PA 19104, USA
    Pediatrics 127:e607-14. 2011
  10. ncbi The incidence and course of retinopathy of prematurity: findings from the early treatment for retinopathy of prematurity study
    William V Good
    Smith Kettlewell Eye Research Institute, 2318 Fillmore St, San Francisco, CA 94115, USA
    Pediatrics 116:15-23. 2005

Research Grants

Detail Information

Publications274 found, 100 shown here

  1. ncbi Can changes in clinical practice decrease the incidence of severe retinopathy of prematurity in very low birth weight infants?
    Lily C Chow
    Division of Neonatology, Department of Pediatrics, Cedars Sinai Medical Center and UCLA School of Medicine, Los Angeles, California, USA
    Pediatrics 111:339-45. 2003
    A wide variability in the incidence of severe retinopathy of prematurity (ROP) is reported by different centers...
  2. pmc Vascular endothelial growth factor in eye disease
    J S Penn
    Vanderbilt University School of Medicine, Nashville, TN, USA
    Prog Retin Eye Res 27:331-71. 2008
    ..In the US, for example, retinopathy of prematurity, diabetic retinopathy and age-related macular degeneration are the principal causes of blindness in the ..
  3. pmc Target ranges of oxygen saturation in extremely preterm infants
    Waldemar A Carlo
    N Engl J Med 362:1959-69. 2010
    ..However, it is unclear what range of oxygen saturation is appropriate to minimize retinopathy without increasing adverse outcomes...
  4. ncbi Longitudinal postnatal weight measurements for the prediction of retinopathy of prematurity
    Carolyn Wu
    Department of Ophthalmology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Arch Ophthalmol 128:443-7. 2010
    To validate longitudinal postnatal weight gain as a method for predicting severe retinopathy of prematurity (ROP) in a US cohort.
  5. ncbi Perinatal growth characteristics and associated risk of developing threshold retinopathy of prematurity
    Karel Allegaert
    Neonatal Intensive Care Unit, Department of Pediatrics, University Hospitals, Leuven, Belgium
    J AAPOS 7:34-7. 2003
    To document perinatal growth characteristics in infants who developed threshold retinopathy of prematurity (ROP) in an attempt to describe prenatal and postnatal growth-related risk factors for threshold ROP.
  6. ncbi Retinopathy of prematurity
    Jing Chen
    Department of Ophthalmology, Harvard Medical School and Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    Angiogenesis 10:133-40. 2007
    b>Retinopathy of prematurity (ROP) is a common blinding disease in children in the developed world despite current treatment, and is becoming increasingly prevalent in the developing world. ROP progresses in two phases...
  7. pmc Efficacy of intravitreal bevacizumab for stage 3+ retinopathy of prematurity
    Helen A Mintz-Hittner
    Department of Ophthalmology and Visual Science, University of Texas Health Science Center at Houston Medical School, Houston, USA
    N Engl J Med 364:603-15. 2011
    b>Retinopathy of prematurity is a leading cause of childhood blindness worldwide...
  8. ncbi Serum concentrations of bevacizumab (avastin) and vascular endothelial growth factor in infants with retinopathy of prematurity
    Tatsuhiko Sato
    Department of Applied Visual Science, Osaka University Graduate School of Medicine, Suita, Japan
    Am J Ophthalmol 153:327-333.e1. 2012
    ..the serum concentrations of bevacizumab and vascular endothelial growth factor (VEGF) in infants with retinopathy of prematurity (ROP) who received intravitreal bevacizumab; and to determine whether the changes in the serum ..
  9. pmc A clinical prediction model to stratify retinopathy of prematurity risk using postnatal weight gain
    Gil Binenbaum
    Division of Ophthalmology, Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, 9 Main, Philadelphia, PA 19104, USA
    Pediatrics 127:e607-14. 2011
    ..prediction model that includes postnatal weight gain to identify infants at risk of developing severe retinopathy of prematurity (ROP)...
  10. ncbi The incidence and course of retinopathy of prematurity: findings from the early treatment for retinopathy of prematurity study
    William V Good
    Smith Kettlewell Eye Research Institute, 2318 Fillmore St, San Francisco, CA 94115, USA
    Pediatrics 116:15-23. 2005
    To estimate the incidence of retinopathy of prematurity (ROP) in the Early Treatment for Retinopathy of Prematurity (ETROP) Study and compare these results with those reported in the Cryotherapy for Retinopathy of Prematurity (CRYO-ROP) ..
  11. pmc Low IGF-I suppresses VEGF-survival signaling in retinal endothelial cells: direct correlation with clinical retinopathy of prematurity
    A Hellstrom
    Department of Clinical Neuroscience, Section of Ophthalmology, and International Pediatric Growth Research Center, The Queen Silvia Children's Hospital, , Sweden
    Proc Natl Acad Sci U S A 98:5804-8. 2001
    b>Retinopathy of prematurity is a blinding disease, initiated by lack of retinal vascular growth after premature birth...
  12. pmc Current update on retinopathy of prematurity: screening and treatment
    Jing Chen
    Department of Ophthalmology, Harvard Medical School, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Curr Opin Pediatr 23:173-8. 2011
    Despite current treatments, retinopathy of prematurity (ROP) remains a major cause of blindness in premature infants and the incidence is increasing with increased survival of infants born at very early gestational ages...
  13. pmc Desmin ensheathment ratio as an indicator of vessel stability: evidence in normal development and in retinopathy of prematurity
    Tailoi Chan-Ling
    Department of Anatomy, Institute for Biomedical Research, University of Sydney, Sydney, NSW 2006, Australia
    Am J Pathol 165:1301-13. 2004
    ..pericyte ensheathment and have examined the DER in normal retinal vascular development and in the kitten retinopathy of prematurity (ROP) model. We also examined the role of mural cells in the pathogenesis of ROP...
  14. ncbi Incidence of retinopathy of prematurity in the United States: 1997 through 2005
    Eleonora M Lad
    Department of Ophthalmology, Stanford University School of Medicine, Stanford, California 94025, USA
    Am J Ophthalmol 148:451-8. 2009
    To determine the incidence of retinopathy of prematurity (ROP) based on a national database and to identify baseline characteristics, demographic information, comorbidities, and surgical interventions.
  15. ncbi Evidence-based screening criteria for retinopathy of prematurity: natural history data from the CRYO-ROP and LIGHT-ROP studies
    James D Reynolds
    Department of Ophthalmology, University at Buffalo, 219 Bryant St, Buffalo, NY 14222, USA
    Arch Ophthalmol 120:1470-6. 2002
    The Multicenter Trial of Cryotherapy for Retinopathy of Prematurity (CRYO-ROP) demonstrated the efficacy of treatment for threshold ROP and indicated the need for worldwide ROP screening...
  16. ncbi Evolution of retinal detachment in posterior retinopathy of prematurity: impact on treatment approach
    Anand Vinekar
    Associated Retinal Consultants, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    Am J Ophthalmol 145:548-555. 2008
    To provide insight into the course of retinal detachment in eyes with aggressive posterior retinopathy of prematurity (APROP).
  17. ncbi Pain management during eye examinations for retinopathy of prematurity in preterm infants: a systematic review
    X Sun
    Department of Pediatrics, University of Ottawa, Ottawa, ON, Canada
    Acta Paediatr 99:329-34. 2010
    ..To assess whether non-pharmacological and/or pharmacological measures lead to decreased pain during an eye examination in preterm infants...
  18. pmc Threshold retinopathy at threshold of viability: the EpiBel study
    K Allegaert
    University Hospital, Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Br J Ophthalmol 88:239-42. 2004
    To describe incidence, co-morbidity characteristics, and risk factors associated with threshold retinopathy of prematurity (ROP) in survivors with a gestational age (GA) of < or =26 weeks at birth.
  19. ncbi Hyperglycemia, insulin and slower growth velocity may increase the risk of retinopathy of prematurity
    J W Kaempf
    Neonatal Intensive Care Unit, Women and Children s Program, Providence St Vincent Medical Center, Portland, OR 97225, USA
    J Perinatol 31:251-7. 2011
    Strategies to reduce Retinopathy of Prematurity (ROP) have focused primarily on respiratory management...
  20. ncbi Natural history of retinopathy of prematurity in infants born before 27 weeks' gestation in Sweden
    Dordi Austeng
    Department of Neuroscience, Uppsala University, 75185 Uppsala, Sweden
    Arch Ophthalmol 128:1289-94. 2010
    To investigate the natural history of retinopathy of prematurity (ROP) in 506 extremely preterm infants born before 27 weeks' gestation in Sweden during a 3-year period.
  21. ncbi Immaturity, perinatal inflammation, and retinopathy of prematurity: a multi-hit hypothesis
    Olaf Dammann
    Division of Newborn Medicine, Floating Hospital for Children at Tufts Medical Center, Boston, MA 02111, USA
    Early Hum Dev 85:325-9. 2009
    To explore the relationship among markers of infection/inflammation in their association with retinopathy of prematurity (ROP).
  22. pmc Wide-field digital imaging based telemedicine for screening for acute retinopathy of prematurity (ROP). Six-year results of a multicentre field study
    Birgit Lorenz
    Department of Ophthalmology, Justus Liebig University Giessen, Universitaetsklinikum Giessen and Marburg GmbH Giessen Campus, 35385 Giessen, Germany
    Graefes Arch Clin Exp Ophthalmol 247:1251-62. 2009
    To report on a 6-year experience with wide-field digital imaging based telemedicine (WFDI telemedicine) to reduce the risk for blindness from retinopathy of prematurity (ROP).
  23. ncbi Outcomes of a protocol-based management for zone 1 retinopathy of prematurity: the Indian Twin Cities ROP Screening Program report number 2
    Subhadra Jalali
    Srimati Kannuri Santhamma Centre for Vitreo retinal Diseases, Kallam Anji Reddy Campus, L V Prasad Eye Institute, L V Prasad Marg, Banjara Hills, Hyderabad, India
    Am J Ophthalmol 151:719-724.e2. 2011
    To report the outcomes of zone 1 aggressive posterior retinopathy of prematurity (ROP) treated with aggressive laser photocoagulation by a protocol-based approach over a 10-year period.
  24. pmc Perinatal infection, inflammation, and retinopathy of prematurity
    Jennifer Lee
    Division of Newborn Medicine, Box 44, Floating Hospital for Children at Tufts Medical Center, 800 Washington St, Boston, MA 02111 1526, USA
    Semin Fetal Neonatal Med 17:26-9. 2012
    The major known risk factors for retinopathy of prematurity (ROP) are extremely low gestational age, exposure to high levels of oxygen early after birth (phase I) and relatively lower oxygen levels later (phase II)...
  25. pmc The neurovascular retina in retinopathy of prematurity
    Anne B Fulton
    Department of Ophthalmology, Children s Hospital and Harvard Medical School, 300 Longwood Ave, Boston, MA 02115 5737, USA
    Prog Retin Eye Res 28:452-82. 2009
    The continuing worldwide epidemic of retinopathy of prematurity (ROP), a leading cause of childhood visual impairment, strongly motivates further research into mechanisms of the disease...
  26. ncbi Incidence and severity of retinopathy of prematurity in extremely premature infants
    Gloria Isaza
    Division of Ophthalmology, Department of Surgery, McMaster University, Hamilton, Ont
    Can J Ophthalmol 47:296-300. 2012
    To analyze incidence and severity of retinopathy of prematurity (ROP) among extremely premature infants.
  27. pmc Effects of oxygen on the development and severity of retinopathy of prematurity
    M Elizabeth Hartnett
    Moran Eye Center, University of Utah, Salt Lake City, UT 84132, USA
    J AAPOS 17:229-34. 2013
    In 1942, when retinopathy of prematurity (ROP) first manifested as retrolental fibroplasia, the technology to monitor or regulate oxygen did not exist, and a fundus examination of preterm infants was not routinely performed...
  28. ncbi Visual acuity, optical components, and macular abnormalities in patients with a history of retinopathy of prematurity
    Wei Chi Wu
    Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Ophthalmology 119:1907-16. 2012
    ..components and spectral-domain optical coherence tomography (OCT) findings in children with a history of retinopathy of prematurity (ROP) and to identify any associations between the OCT findings and the visual acuities of the patients.
  29. ncbi Poor postnatal weight gain: a risk factor for severe retinopathy of prematurity
    D K Wallace
    Departments of Ophthalmology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7040, USA
    J AAPOS 4:343-7. 2000
    This study aimed to investigate the relationship between rate of postnatal weight gain and severity of retinopathy of prematurity (ROP).
  30. pmc NeOProM: Neonatal Oxygenation Prospective Meta-analysis Collaboration study protocol
    Lisa M Askie
    NHMRC Clinical Trials Centre, University of Sydney, Parramatta Road, Camperdown, 2050, Australia
    BMC Pediatr 11:6. 2011
    ..oxygen saturations of >90%) have been reported to have greater rates of morbidity including retinopathy of prematurity and chronic lung disease...
  31. pmc Importance of early postnatal weight gain for normal retinal angiogenesis in very preterm infants: a multicenter study analyzing weight velocity deviations for the prediction of retinopathy of prematurity
    Carolyn Wu
    Department of Ophthalmology, Children s Hospital Boston, 300 Longwood Ave, Fegan 4, Boston, MA 02115, USA
    Arch Ophthalmol 130:992-9. 2012
    To assess WINROP (https://winrop.com), an algorithm using postnatal weight measurements, as a tool for the prediction of retinopathy of prematurity (ROP) in a large geographically and racially diverse study population.
  32. pmc The influence of gestational age on the dynamic behavior of other risk factors associated with retinopathy of prematurity (ROP)
    Joao Borges Fortes Filho
    Departments of Ophthalmology and Pediatrics, Newborn Section, Medical School, Federal University of Rio Grande do Sul and Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil
    Graefes Arch Clin Exp Ophthalmol 248:893-900. 2010
    Improved survival of preterm neonates has increased the incidence of retinopathy of prematurity (ROP) in many middle-income countries.
  33. ncbi Efficacy of topical anesthetics to reduce pain in premature infants during eye examinations for retinopathy of prematurity
    Virginia A Marsh
    Neonatal Intensive Care Unit, Nursing Department, Women s Hospital, Greensboro, NC, USA
    Ann Pharmacother 39:829-33. 2005
    Eye examinations for retinopathy of prematurity (ROP) are stressful and probably painful, but many ophthalmologists do not apply topical anesthetics because their efficacy in reducing pain has not been established.
  34. pmc Results of screening for retinopathy of prematurity in a large nursery in Kuwait: Incidence and risk factors
    Vivek B Wani
    Al Bahar Ophthalmology Center, Kuwait City, Kuwait
    Indian J Ophthalmol 58:204-8. 2010
    The aim of the study was to report the incidence of retinopathy of prematurity (ROP) and severe ROP and identify the risk factors for their development in a large nursery in Kuwait.
  35. ncbi Aggressive posterior retinopathy of prematurity
    Kimberly A Drenser
    Associated Retinal Consultants, Royal Oak, Michigan, USA
    Retina 30:S37-40. 2010
    The purpose of this study was to review the anatomic and functional outcomes of aggressive posterior retinopathy of prematurity occurring at the authors' institution.
  36. ncbi Risk factors and growth factors in ROP
    C Romagnoli
    Division of Neonatology, Catholic University of Rome, Largo A Gemelli, 8 00168, Rome, Italy
    Early Hum Dev 85:S79-82. 2009
    b>Retinopathy of prematurity (ROP) is a multifactorial disease which incidence is increasing with increasing survival of very preterm infants...
  37. ncbi Incidence of retinopathy of prematurity in infants born before 27 weeks' gestation in Sweden
    Dordi Austeng
    Department of Ophthalmology, University Hospital, Uppsala, Sweden
    Arch Ophthalmol 127:1315-9. 2009
    To determine the incidence of retinopathy of prematurity (ROP) in extremely preterm infants born before 27 weeks' gestation in Sweden during a 3-year period.
  38. ncbi Effects and complications of bevacizumab use in patients with retinopathy of prematurity: a multicenter study in taiwan
    Wei Chi Wu
    Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Ophthalmology 118:176-83. 2011
    To investigate the effects and complications of the anti-vascular endothelial growth factor agent bevacizumab in the treatment of retinopathy of prematurity (ROP) in Taiwanese patients.
  39. pmc Pulse oximetry, severe retinopathy, and outcome at one year in babies of less than 28 weeks gestation
    W Tin
    Department of Paediatrics, South Cleveland Hospital, Middlesbrough TS4 3BW, UK
    Arch Dis Child Fetal Neonatal Ed 84:F106-10. 2001
    ..whether differing policies with regard to the control of oxygen saturation have any impact on the number of babies who develop retinopathy of prematurity and the number surviving with or without signs of cerebral palsy at one year.
  40. pmc Retinopathy of prematurity: understanding ischemic retinal vasculopathies at an extreme of life
    Przemyslaw Sapieha
    Department of Ophthalmology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 120:3022-32. 2010
    b>Retinopathy of prematurity (ROP) is a major complication of preterm birth...
  41. ncbi Hyperglycemia and retinopathy of prematurity in very low birth weight infants
    Ruchira Garg
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287 3200, USA
    J Perinatol 23:186-94. 2003
    b>Retinopathy of prematurity (ROP) remains a leading cause of morbidity in the very low-birth-weight (VLBW) infant. This study investigates a possible association between serum/blood glucose and the development of ROP.
  42. ncbi Intravitreal injection of bevacizumab (avastin) for treatment of stage 3 retinopathy of prematurity in zone I or posterior zone II
    Helen A Mintz-Hittner
    Department of Ophthalmology and Visual Science, University of Texas Health Science Center Houston Medical School, Houston, TX 77030, USA
    Retina 28:831-8. 2008
    To report a retrospective, consecutive, noncomparative case series of moderate and severe stage 3 retinopathy of prematurity (ROP) in zone I or posterior zone II treated by bilateral intravitreal injections of bevacizumab (Avastin; ..
  43. pmc Suppression of retinal neovascularization by erythropoietin siRNA in a mouse model of proliferative retinopathy
    Jing Chen
    Department of Ophthalmology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Invest Ophthalmol Vis Sci 50:1329-35. 2009
    ..The authors investigated the inhibition of retinal EPO mRNA expression with RNA interference as a potential strategy to suppress retinal neovascularization and to prevent proliferative retinopathy...
  44. pmc The oscillatory potentials of the dark-adapted electroretinogram in retinopathy of prematurity
    James D Akula
    Department of Ophthalmology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Invest Ophthalmol Vis Sci 48:5788-97. 2007
    ..To study the development of the electroretinographic (ERG) oscillatory potentials (OPs) in two rat models of ROP and in human subjects with a history of ROP...
  45. ncbi Efficacy of intravitreal injection of bevacizumab for severe retinopathy of prematurity: a pilot study
    S Kusaka
    Department of Ophthalmology, Osaka University Medical School, Suita, Osaka, Japan
    Br J Ophthalmol 92:1450-5. 2008
    The aim of the study was to evaluate the short-term efficacy of intravitreal injections of bevacizumab for severe retinopathy of prematurity (ROP).
  46. ncbi Incidence and risk factors of retinopathy of prematurity in a tertiary care newborn unit in New Delhi
    R Maheshwari
    Department of Paediatrics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
    Natl Med J India 9:211-4. 1996
    BACKGROUND: Retinopathy of prematurity (RoP) has become more common in developed countries with an improvement in survival of very premature infants...
  47. ncbi Intravitreal bevacizumab for retinopathy of prematurity
    Björn C Harder
    Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht Karls University, Heidelberg, Germany
    J Ocul Pharmacol Ther 27:623-7. 2011
    To evaluate the therapeutic effect of a single intravitreal injection of bevacizumab for treatment of threshold retinopathy in retinopathy of prematurity (ROP).
  48. pmc A co-twin study of the relative effect of birth weight and gestational age on retinopathy of prematurity
    S J Woo
    Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea
    Eye (Lond) 25:1478-83. 2011
    To determine the relative effect of birth weight and gestational age on retinopathy of prematurity (ROP) using preterm twin pairs discordant for birth weight.
  49. ncbi Does candidemia predict threshold retinopathy of prematurity in extremely low birth weight (</=1000 g) neonates?
    M G Karlowicz
    Department of Pediatrics, Eastern Virginia Medical School, Children s Hospital of the King s Daughters, Norfolk, Virginia, USA
    Pediatrics 105:1036-40. 2000
    Extreme prematurity is a risk factor for both candidemia and threshold retinopathy of prematurity (ROP) and may confound the reported association between these conditions.
  50. ncbi Retinopathy of prematurity in the UK I: the organisation of services for screening and treatment
    L Haines
    Research Division, Royal College of Paediatrics and Child Health, London, UK
    Eye (Lond) 16:33-8. 2002
    To ascertain how closely services for the screening and treatment of retinopathy of prematurity (ROP) were organised on a national level in 1995.
  51. ncbi Pain management during retinopathy of prematurity eye examinations: a systematic review
    Haifa A Samra
    College of Nursing, South Dakota State University, Brookings, SD 57007, USA
    Adv Neonatal Care 9:99-110. 2009
    b>Retinopathy of prematurity (ROP) remains a concern for many preterm infants...
  52. ncbi [Retinopathy of prematurity in extremely low birth weight infants: a Tokyo multicenter study]
    Miina Hiraoka
    Department of Neonatology, Tokyo Metropolitan Bokutoh Hospital, Japan
    Nihon Ganka Gakkai Zasshi 108:600-5. 2004
    To investigate how the increase in survival rate in extremely low birth weight (a birth weight of 1,000 g or less) infants had affected the incidence of retinopathy of prematurity (ROP) and the frequency of laser treatment.
  53. ncbi Lower oxygen saturation alarm limits decrease the severity of retinopathy of prematurity
    Deborah K Vanderveen
    Department of Ophthalmology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J AAPOS 10:445-8. 2006
    To determine whether lowering oxygen saturation alarm limits for infants at risk for retinopathy of prematurity (ROP) reduces its incidence and/or severity.
  54. ncbi Retinopathy of prematurity
    Ann Hellstrom
    Department of Ophthalmology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden
    Lancet 382:1445-57. 2013
    ..retinas of preterm neonates are susceptible to insults that disrupt neurovascular growth, leading to retinopathy of prematurity. Suppression of growth factors due to hyperoxia and loss of the maternal-fetal interaction result in an ..
  55. pmc Prevalence and course of strabismus through age 6 years in participants of the Early Treatment for Retinopathy of Prematurity randomized trial
    Deborah K Vanderveen
    Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    J AAPOS 15:536-40. 2011
    To present strabismus data for children who participated in the Early Treatment for Retinopathy of Prematurity (ETROP) randomized trial.
  56. ncbi Efficacy of sucrose to reduce pain in premature infants during eye examinations for retinopathy of prematurity
    Peter Gal
    Pharmacy Division, Greensboro Area Health Education Center, Greensboro, NC 27401 1020, USA
    Ann Pharmacother 39:1029-33. 2005
    Eye examinations for retinopathy of prematurity (ROP) are painful to the neonate...
  57. ncbi New insight into the pathogenesis of retinopathy of prematurity: assessment of whole-genome expression
    Jacek J Pietrzyk
    Department of Pediatrics, Jagiellonian University, Krakow, Poland
    Pediatr Res 73:476-83. 2013
    b>Retinopathy of prematurity (ROP) is one of the most common preventable causes of blindness and impaired vision among children in developed countries...
  58. ncbi Neonatal bacteremia and retinopathy of prematurity: the ELGAN study
    Kristi Washburn Tolsma
    Division of Newborn Medicine, Floating Hospital for Children, Tufts Medical Center, 800 Washington St, PO Box 854, Boston, MA 02111 1526, USA
    Arch Ophthalmol 129:1555-63. 2011
    To explore whether early or late and presumed or definite neonatal bacteremia are associated with an increased risk of severe retinopathy of prematurity (ROP).
  59. ncbi Are we there yet? Bevacizumab therapy for retinopathy of prematurity
    Brian A Darlow
    Department of Paediatrics, Christchurch School of Medicine and Health Sciences, University of Otago Christchurch, PO Box 4345, Christchurch 8140, New Zealand
    Arch Dis Child Fetal Neonatal Ed 98:F170-4. 2013
    The publication of the BEAT-ROP study of bevacizumab (Avastin) treatment for Zone I and II retinopathy of prematurity (ROP) has raised hopes that there might now be a simpler, cheaper and more effective treatment than laser therapy, the ..
  60. pmc Retinopathy of prematurity: a study of prevalence and risk factors
    Abdel H A A Hakeem
    Department of Pediatrics, Faculty of Medicine, Al Minia University, Egypt
    Middle East Afr J Ophthalmol 19:289-94. 2012
    b>Retinopathy of prematurity (ROP) is a serious complication of prematurity treatment and can lead to blindness unless recognized and treated early.
  61. ncbi Incidence and risk factors for retinopathy of prematurity in the West Black Sea region, Turkey
    Atilla Alpay
    Department of Ophthalmology, Zonguldak Karaelmas University Faculty of Medicine, Zonguldak, Turkey
    Turk J Pediatr 54:113-8. 2012
    The objective of this study was to determine the incidence, risk factors and severity of retinopathy of prematurity (ROP) and to establish screening criteria for our region...
  62. ncbi Aggressive posterior retinopathy of prematurity in large preterm babies in South India
    Parag K Shah
    Department of Pediatric Retina and Ocular Oncology, Aravind Eye Hospital, Avinashi Road, Coimbatore 641 014, Tamil Nadu, India
    Arch Dis Child Fetal Neonatal Ed 97:F371-5. 2012
    To describe aggressive posterior retinopathy of prematurity (APROP) in a subset of premature babies, having gestational age (GA) of ≥28 weeks and birth weight (BW) of ≥1000 g.
  63. ncbi The influence of early postnatal nutrition on retinopathy of prematurity in extremely low birth weight infants
    Peter J Porcelli
    Department of Pediatrics, Wake Forest University, Winston Salem, NC 27157, United States
    Early Hum Dev 86:391-6. 2010
    b>Retinopathy of prematurity(ROP) is the most common serious ophthalmic disease in preterm infants. Human milk may provide a protective effect for ROP; however, beneficial effects of human milk preclude randomized trials...
  64. ncbi Retinopathy of prematurity as a major cause of severe visual impairment and blindness in children in schools for the blind in Guadalajara city, Mexico
    L C Zepeda-Romero
    Retinopathy of Prematurity Clinic, Hospital Civil de Guadalajara, Centro Universitario de Ciencias de Salud, Universidad de Guadalajara, Calle Hospital No 278, Guadalajara, Jalisco, Mexico
    Br J Ophthalmol 95:1502-5. 2011
    To determine the causes of blindness in students attending schools for the blind in Guadalajara city, Mexico and to assess the availability of screening for retinopathy of prematurity (ROP) in local neonatal intensive care units.
  65. ncbi Predicting proliferative retinopathy in a Brazilian population of preterm infants with the screening algorithm WINROP
    Anna Lena Hard
    Department of Ophthalmology, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden
    Arch Ophthalmol 128:1432-6. 2010
    To retrospectively validate the WINROP (weight, insulinlike growth factor I, neonatal, retinopathy of prematurity [ROP]) algorithm in a Brazilian population...
  66. ncbi Assessment of the contribution of cytokine plasma levels to detect retinopathy of prematurity in very low birth weight infants
    Rita C Silveira
    Department of Pediatrics, Newborn Section, Medical School, Federal University of Rio Grande do Sul, and Hospital de Clinicas de Porto Alegre, Porto Alegre RS, Brazil
    Invest Ophthalmol Vis Sci 52:1297-301. 2011
    To prospectively study the association of high cytokine plasma levels with later development of retinopathy of prematurity (ROP) in preterm infants with early-onset sepsis to assess a laboratory test to detect ROP.
  67. pmc Arginase 2 deletion reduces neuro-glial injury and improves retinal function in a model of retinopathy of prematurity
    Subhadra P Narayanan
    Vascular Biology Center, Georgia Health Sciences University, Augusta, Georgia, United States of America
    PLoS ONE 6:e22460. 2011
    b>Retinopathy of prematurity (ROP) is a major cause of vision impairment in low birth weight infants...
  68. ncbi Fish-oil fat emulsion supplementation may reduce the risk of severe retinopathy in VLBW infants
    Dorota Pawlik
    Department of Neonatology, Jagiellonian University Medical College, Krakow, Kopernika, Poland
    Pediatrics 127:223-8. 2011
    ..Moreover, within the first 2 to 3 weeks of life, the main sources of lipids for premature infants are fat emulsions, which do not contain DHA...
  69. ncbi Intravitreal bevacizumab in aggressive posterior retinopathy of prematurity
    Rajvardhan Azad
    Indian J Ophthalmol 55:319; author reply 320. 2007
  70. ncbi Risk factors for severe retinopathy of prematurity in preterm low birth weight neonates
    Pardeep Kumar
    Division of Neonatology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi 110029, India
    Indian J Pediatr 78:812-6. 2011
    To evaluate the risk factors predisposing to severe retinopathy of prematurity (ROP) in a level III neonatal unit. This retrospective study was conducted in a tertiary care neonatal and ophthalmic center.
  71. ncbi Association of systemic risk factors with the progression of laser-treated retinopathy of prematurity to retinal detachment
    Dan H Bourla
    Jules Stein Eye Institute, Los Angeles, California, USA
    Retina 28:S58-64. 2008
    To identify systemic risk factors associated with treatment failure of diode laser photocoagulation for threshold or prethreshold retinopathy of prematurity (ROP).
  72. ncbi The anatomy of the rat eye with oxygen-induced retinopathy
    James D Akula
    Department of Ophthalmology, Children s Hospital Boston, Boston, MA 02115, USA
    Doc Ophthalmol 120:41-50. 2010
    ..in fundus photographs) and retinal dysfunction (in electroretinographs) in Sprague-Dawley rat models of retinopathy of prematurity (ROP)...
  73. ncbi Pain relief for premature infants during ophthalmology assessment
    Yogavijayan Kandasamy
    Department of Neonatology, Townsville Hospital, Queensland, Australia
    J AAPOS 15:276-80. 2011
    The ophthalmological examination of premature infants, which is essential for the detection of retinopathy of prematurity (ROP), can be painful and distressing for the infant...
  74. ncbi Postnatal risk factors of retinopathy of prematurity
    Tae Im Kim
    Department of Ophthalmology, Asan Medical Centre, University of Ulsan College of Medicine, Seoul, Korea
    Paediatr Perinat Epidemiol 18:130-4. 2004
    To investigate the postnatal risk factors of retinopathy of prematurity (ROP), we analysed demographic and clinical data abstracted from the medical records of 425 premature babies who were examined for ROP between January 1994 and ..
  75. pmc Genetic screening of Wnt signaling factors in advanced retinopathy of prematurity
    Miki Hiraoka
    Department of Ophthalmology, Nippon Medical School, Tokyo, Japan
    Mol Vis 16:2572-7. 2010
    To evaluate the possibility of genetic involvement in retinopathy of prematurity (ROP). Although ROP is most often associated with low birthweight and low gestational age, these factors do not necessarily predict the severity of ROP...
  76. ncbi Systemic manifestations in response to mydriasis and physical examination during screening for retinopathy of prematurity
    Ryan Rush
    Department of Pediatrics, Texas Tech University Health Sciences Center and Northwest Texas Healthcare Systems, Amarillo, TX 79106, USA
    Retina 24:242-5. 2004
    ..determine whether adverse effects manifested via vital sign changes during the screening examination for retinopathy of prematurity (ROP) are due to the pharmacologic properties of the eye drops or to physical manipulation of the eyes...
  77. pmc Intraretinal calcium channels and retinal morbidity in experimental retinopathy of prematurity
    Bruce A Berkowitz
    Department of Anatomy and Cell Biology, Wayne State University, Detroit, MI, USA
    Mol Vis 17:2516-26. 2011
    To test the hypothesis that intraretinal calcium channels participate in retinal morbidity in a variable oxygen (VO) model of retinopathy of prematurity.
  78. ncbi Incidence and risk factors of retinopathy of prematurity in a tertiary eye hospital in Tehran
    R Karkhaneh
    Eye Research Centre, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran
    Br J Ophthalmol 92:1446-9. 2008
    To determine the incidence and risk factors of retinopathy of prematurity (ROP) in premature infants referred to a tertiary eye hospital during 2003-7 to provide preliminary evidence about ROP in Iran.
  79. ncbi Computer-assisted measurement of retinal vascular width and tortuosity in retinopathy of prematurity
    Amanda E Kiely
    School of Medicine, Department of Ophthalmology, Duke University Medical Center, Durham, NC 27710, USA
    Arch Ophthalmol 128:847-52. 2010
    ..To validate the accuracy of ROPtool software in measuring retinal vascular width and tortuosity in a large image set compared with expert diagnoses...
  80. ncbi Vascular abnormalities in aggressive posterior retinopathy of prematurity detected by fluorescein angiography
    Tadashi Yokoi
    Department of Ophthalmology, National Center for Child Health and Development, Tokyo, Japan
    Ophthalmology 116:1377-82. 2009
    To evaluate fluorescein angiography (FA) in eyes with aggressive posterior retinopathy of prematurity (AP-ROP).
  81. pmc Maintaining retinal astrocytes normalizes revascularization and prevents vascular pathology associated with oxygen-induced retinopathy
    Michael I Dorrell
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Glia 58:43-54. 2010
    ..Methods developed to target and protect glial cells may provide a novel strategy by which normalized revascularization can be promoted and the consequences of abnormal NV in retinal vascular diseases can be prevented...
  82. ncbi Antivascular endothelial growth factor for retinopathy of prematurity
    Helen A Mintz-Hittner
    Department of Ophthalmology and Visual Science, University of Texas Health Science Center, Houston University of Texas Houston Medical School, 6410 Fannin St, Houston, TX 77030 5204, USA
    Curr Opin Pediatr 21:182-7. 2009
    This review will discuss a potentially more effective treatment for retinopathy of prematurity (ROP) with fewer acute and long-term complications...
  83. ncbi Case series of angle-closure glaucoma after laser treatment for retinopathy of prematurity
    Lucas Trigler
    Duke University Eye Center, Durham, NC, USA
    J AAPOS 9:17-21. 2005
    Laser photocoagulation is the current treatment standard for severe retinopathy of prematurity (ROP). Uncommon, but well recognized complications include cataract, and vitreous and retinal hemorrhage...
  84. ncbi Retinopathy of prematurity: an epidemic in the making
    Graham E Quinn
    Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104, USA
    Chin Med J (Engl) 123:2929-37. 2010
    To explore the etiology, incidence and methods to prevent and treat severe retinopathy of prematurity (ROP), which is rapidly becoming a threat to the vision of babies in areas of the world where increasing numbers of premature babies are ..
  85. pmc Insulin-like growth factor binding protein-3 mediates vascular repair by enhancing nitric oxide generation
    Jennifer L Kielczewski
    Program in Stem Cell Biology and Regenerative Medicine, University of Florida, Gainesville, FL 32610, USA
    Circ Res 105:897-905. 2009
    ..This study was undertaken to investigate the mechanism of IGFBP-3 effects on EPC function and how IGFBP-3 mediates cytoprotection following vascular injury...
  86. pmc Foveal fine structure in retinopathy of prematurity: an adaptive optics Fourier domain optical coherence tomography study
    Daniel X Hammer
    Physical Sciences Inc, 20 New England Business Center, Andover, MA 01810, USA
    Invest Ophthalmol Vis Sci 49:2061-70. 2008
    To describe the fine structure of the fovea in subjects with a history of mild retinopathy of prematurity (ROP) using adaptive optics-Fourier domain optical coherence tomography (AO-FDOCT).
  87. ncbi Screening for retinopathy of prematurity: is it painful?
    Sylvia Belda
    Department of Pediatrics, Hospital Doce de Octubre, Madrid, Spain
    Biol Neonate 86:195-200. 2004
    Screening programmes for retinopathy of prematurity have shown to reduce unfavourable visual outcome and to be cost-effective...
  88. ncbi Retinopathy of prematurity in extremely premature infants
    Ronald G W Teed
    Storm Eye Institute, Medical University of South Carolina, Department of Ophthalmology, Charleston, South Carolina 29425 6760, USA
    J AAPOS 13:370-3. 2009
    The incidence and severity of retinopathy of prematurity (ROP) in extremely premature infants have not been reported since publication of the Early Treatment of ROP study results. The survival rate of these infants continues to increase...
  89. ncbi Pain in neonates during screening for retinopathy of prematurity using binocular indirect ophthalmoscopy and wide-field digital retinal imaging: a randomised comparison
    C A Dhaliwal
    Centre for Reproductive Biology, Queens Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Arch Dis Child Fetal Neonatal Ed 95:F146-8. 2010
    To compare the pain experienced by premature infants undergoing wide-field digital retinal imaging (WFDRI) and binocular indirect ophthalmoscopy (BIO) for retinopathy of prematurity (ROP) screening.
  90. doi Intravitreous bevacizumab as anti-vascular endothelial growth factor therapy for retinopathy of prematurity: a morphologic study
    Lingkun Kong
    Arch Ophthalmol 126:1161-3. 2008
  91. ncbi Characterization of changes in blood vessel width and tortuosity in retinopathy of prematurity using image analysis
    Conor Heneghan
    Department of Electronic and Electrical Engineering, University College Dublin, Belfield, Dublin 4, Ireland
    Med Image Anal 6:407-29. 2002
    ..For example, a common condition associated with retinopathy of prematurity (ROP) is so-called plus disease, characterised by increased vascular dilation and tortuosity...
  92. ncbi Screening for retinopathy of prematurity in a tertiary care newborn unit in Turkey: frequency, outcomes, and risk factor analysis
    Fatih Mehmet Mutlu
    Department of Ophthalmology, Gulhane Military Medical Academy and Medical School, Ankara, Turkey
    J Pediatr Ophthalmol Strabismus 45:291-8. 2008
    To report the frequency, risk factors, and outcomes of screening for retinopathy of prematurity (ROP).
  93. ncbi Diltiazem reduces retinal neovascularization in a mouse model of oxygen induced retinopathy
    R D Higgins
    Department of Pediatrics, Georgetown University Medical Center, Washington, DC 20007, USA
    Curr Eye Res 18:20-7. 1999
    ....
  94. ncbi Racial variation in retinopathy of prematurity. The Cryotherapy for Retinopathy of Prematurity Cooperative Group
    R A Saunders
    N Edgar Miles Center for Pediatric Ophthalmology, Department of Ophthalmology, Medical University of South Carolina, Charleston, USA
    Arch Ophthalmol 115:604-8. 1997
    To determine and compare the incidence of severe, vision-threatening retinopathy of prematurity (ROP) in black and white low-birth-weight infants.
  95. pmc HMG-CoA reductase inhibitors (statin) prevents retinal neovascularization in a model of oxygen-induced retinopathy
    Manuela Bartoli
    Department of Ophthalmology, University of South Carolina School of Medicine, Columbia, South Carolina 29203, USA
    Invest Ophthalmol Vis Sci 50:4934-40. 2009
    ..Recent studies have emphasized the beneficial effects of inhibitors of HMG-CoA reductase (statins) in preventing vascular dysfunction. In the present study, the authors characterized the therapeutic effects of statins on RNV...
  96. ncbi Multifocal ERG in subjects with a history of retinopathy of prematurity
    Anne B Fulton
    Department of Ophthalmology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Doc Ophthalmol 111:7-13. 2005
    Investigate the function of the central retina in subjects with a history of retinopathy of prematurity (ROP).
  97. pmc The role of supplemental oxygen and JAK/STAT signaling in intravitreous neovascularization in a ROP rat model
    Grace Byfield
    Department of Ophthalmology, University of North Carolina, Chapel Hill, North Carolina 27599 7041, USA
    Invest Ophthalmol Vis Sci 50:3360-5. 2009
    To investigate whether oxygen stresses experienced in retinopathy of prematurity (ROP) trigger signaling through reactive oxygen species (ROS) and whether the Janus kinase-signal transducer and activator of transcription (JAK/STAT) ..
  98. pmc A physiologic reduced oxygen protocol decreases the incidence of threshold retinopathy of prematurity
    Kenneth W Wright
    Cedars Sinai Medical Center, Los Angeles, California, USA
    Trans Am Ophthalmol Soc 104:78-84. 2006
    To report the incidence of threshold retinopathy of prematurity (ROP) in very low birth weight premature infants from three neonatal intensive care units (NICUs) before and after implementation of a physiologic reduced oxygen protocol (..
  99. ncbi Retinopathy of prematurity: the life of a lifetime disease
    William Tasman
    Department of Ophthalmology, Jefferson Medical College, and Wills Eye Hospital, 840 Walnut Street, Suite 1510, Philadelphia, PA 19107, USA
    Am J Ophthalmol 141:167-74. 2006
    To provide information on retrolental fibroplasias (RLF), later known as retinopathy of prematurity.
  100. ncbi Long-term ophthalmic outcome of low birth weight children with and without retinopathy of prematurity
    Anna R O'Connor
    Division of Child Health, University of Nottingham, Nottingham, United Kingdom
    Pediatrics 109:12-8. 2002
    A prospective study of retinopathy of prematurity (ROP) of 505 infants who weighed <1701 g at birth was undertaken in the mid-1980s...
  101. ncbi Long-term follow-up of visual functions in prematurely born children--a prospective population-based study up to 10 years of age
    Gerd Holmstrom
    Department of Ophthalmology, University Hospital, Uppsala, Sweden
    J AAPOS 12:157-62. 2008
    ..There is still no consensus on how they should be followed. The purpose of this study was to evaluate predictive factors for problems in premature children at ten years of age and to discuss follow-up recommendations...

Research Grants64

  1. A Novel Model to Study Retinopathy of Prematurity
    David Moscatelli; Fiscal Year: 2003
    DESCRIPTION: (Applicant's Abstract) Retinopathy of Prematurity (ROP) is a vasoproliferative disease affecting the retina of premature babies and is the major cause of blindness in children...
  2. Mechanisms of Angiogenesis in Retinopathy of Prematurity
    Mary Elizabeth Hartnett; Fiscal Year: 2009
    Oxygen fluctuations and hyperoxia are risk factors for severe retinopathy of prematurity (ROP)...
  3. Mechanisms of Angiogenesis of Retinopathy of Prematurity
    MARY ELIZABETH RUTH HARTNETT; Fiscal Year: 2013
    Oxygen fluctuations and increased inspired oxygen (hyperoxia) are risk factors for severe retinopathy of prematurity (ROP)...
  4. Cyr61/CCN1-Induced Angiogenesis and Vasculogenesis in the Retina
    Brahim Chaqour; Fiscal Year: 2010
    ..g., retinopathy of prematurity, age-related macular degeneration, diabetic retinopathy, etc)...
  5. Downregulation of Rod Metabolism in Retinopathy of Prematurity
    JAMES DANIEL AKULA; Fiscal Year: 2010
    ..Specifically, it will compare results from two preclinical trials of novel interventions in retinopathy of prematurity (ROP)...
  6. Astrocyte Development and Reactive Gliosis
    Teri L Belecky-Adams; Fiscal Year: 2012
    ..including glaucoma, age-related macular degeneration, retinitis pigmentosa, diabetic retinopathy and retinopathy of prematurity. The cells that transform into reactive glia arise from the region that becomes the optic nerve, and in ..
  7. Vision Sciences Training Grant
    Carol A Mason; Fiscal Year: 2013
    ..retinal disorders, with a focus on macular degeneration, retinitis pigmentosa, diabetic retinopathy, and retinopathy of prematurity. The research carried out by the mentors and trainees matches the goals in NEI's long-standing plan ..
  8. CYP1B1, NF-kB , and Regulation of Angiogenesis
    TAMMY LYNN PALENSKI; Fiscal Year: 2012
    ..However, dysregulation of angiogenesis is associated with pathogenesis many diseases including retinopathy of prematurity, diabetic retinopathy and age-related macular degeneration...
  9. Regulation and Function of the Matricellular Protein CCN1 in Ischemic Retinopathy
    Brahim Chaqour; Fiscal Year: 2013
    ..by applicant): Disorders of retinal vessel growth and function are responsible for vision loss in retinopathy of prematurity (ROP), a leading cause of vision impairment and blindness in childhood...
  10. Interphotoreceptor Matrix Based Cell Delivery Vehicle for Retinal Regeneration
    Rebecca L Carrier; Fiscal Year: 2012
    ..for retinal degeneration associated with a wide variety of diseases, including macular degeneration and retinopathy of prematurity. The specific aims of the project, designed to test the central hypothesis, include developing and ..
  11. The control of retinal vascular development by Norrin and Frizzled4
    Jeremy Nathans; Fiscal Year: 2013
    ..Age-related macular degeneration, diabetic retinopathy, and retinopathy of prematurity are all associated with the growth of new blood vessels (neovascularization) into or on the surface of ..
  12. Immune Mechanisms in Choroidal Neovascularization
    Rajendra Apte; Fiscal Year: 2009
    ..has broad implications for the understanding of ophthalmic diseases such as AMD, diabetic retinopathy, retinopathy of prematurity and ocular melanomas which affect diverse age groups and wherein angiogenesis is critical to the disease ..
  13. Ophthalmologic Follow-up Care for Children Born Very-Low-Birth-Weight
    CHIHHUNG JASON WANG; Fiscal Year: 2012
    ..b>Retinopathy of Prematurity (ROP) is the most common cause of long-term visual impairment in these infants, although even premature ..
  14. Extracellular Proteinases in Ocular Neovascularization
    Arup Das; Fiscal Year: 2010
    ..cause of blindness in the United States among working-age adults (diabetic retinopathy) and infants (retinopathy of prematurity)...
  15. The Role of the Nicotinic Cholinergic Pathway in Retinopathy of Prematurity
    John P Cooke; Fiscal Year: 2013
    b>Retinopathy of prematurity (ROP), is a leading cause of vision impairment and blindness in children in the United States, due to pathological retinal neovascularization...
  16. Atlas - A Handheld High Resolution Wide-field Retinal Imager
    PAUL ANDREW YATES; Fiscal Year: 2013
    7. Project Summary Retinopathy of prematurity (ROP) is a treatable eye disease which affects the vision of neonatal infants with a birth weight of <1500g or gestational age of <30 weeks...
  17. Role of Caveolin-1 in the Maintenance of Blood-retinal Barrier Integrity
    Michael H Elliott; Fiscal Year: 2013
    ..pathology in three major causes of blindness: diabetic retinopathy;age- related macular degeneration;and retinopathy of prematurity. Recent evidence indicates that caveolin-1 (Cav- 1), an integral protein component of specialized lipid ..
  18. Non-canonical VEGF receptor signaling regulates retinal neovascularization
    MICHAEL EDWIN BOULTON; Fiscal Year: 2012
    Neovascular diseases of the eye include retinopathy of prematurity, proliferative diabetic retinopathy, and the exudative or "wet" form of age-related macular degeneration (AMD)...
  19. Fatty Acid Binding Protein and Pathological Retinal Vascularization
    Magali Saint-Geniez; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Retinopathy of prematurity (ROP) and diabetic retinopathy (DR) are the two leading causes of blindness in children and working-age adults, respectively...
  20. CYP1B1 and Retinopathy of Prematurity
    Nader Sheibani; Fiscal Year: 2010
    ..Understanding how CYP1 B1 and its metabolites regulate retinal vascular homeostasis will provide insight into CYP1 B1 mechanisms of action and aid in the development of alternative ways to modulate retinal angiogenesis. ..
  21. Novel Angiogenesis Inhibitors Targeting the Anthrax Toxin Receptors
    MICHAEL SEAN ROGERS; Fiscal Year: 2012
    ..thus encompass disorders of ocular angiogenesis such as macular degeneration, diabetic retinopathy, retinopathy of prematurity, and glaucoma, corneal neovascularization associated with conditions such as Herpetic Keratitis, ..
  22. EYA in Retinal Angiogenesis
    Rashmi S Hegde; Fiscal Year: 2013
    ..This occurs in conditions such as retinopathy of prematurity (ROP), age-related macular degeneration, and diabetic retinopathy...
  23. Chronic intermittent hyperoxia and development of respiratory control
    Ryan W Bavis; Fiscal Year: 2013
    ..O2 exposures, however, since hyperoxia may contribute to pathologies such as bronchopulmonary dysplasia, retinopathy of prematurity, and cerebral palsy...
  24. Role of Nrf2 in retinal vascularization and ROP
    Elia J Duh; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Retinopathy of prematurity (ROP) is the leading cause of blindness in the U.S. and other developed countries in the pediatric population...
  25. Neuronal guidance molecules control revascularization in retinopathy
    Lois Smith; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Diabetic retinopathy (DR) and retinopathy of prematurity (ROP) are characterized by vessel loss followed by hyper-vascularization at the non-vascularized border...
  26. Bcl-2 and ocular neovascularization
    Christine M Sorenson; Fiscal Year: 2013
    ..provided by applicant): Retinal neovascularization and choroidal neovascularization (CNV), as occur in retinopathy of prematurity (ROP) and age-related macular degeneration (AMD), are major causes of blindness...
  27. Molecular and Clinical Pharmacology of Retinopathy of Prematurity
    Jacob V Aranda; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Retinopathy of prematurity (ROP) occurs in 50 to 80% of preterm babies born weighing less than 1250 grams...
  28. Vasculogenesis and hyperoxia in the developing retina.
    GERARD ANTHONY LUTTY; Fiscal Year: 2013
    ..acellular vascular segments) will be determined using the mouse oxygen-induced retinopathy model for retinopathy of prematurity (ROP)...
  29. Identification of Common Polymorphisms Affecting Angiogenesis
    ROBERT J D'AMATO; Fiscal Year: 2013
    ..In the posterior eye, conditions such as macular degeneration, diabetic retinopathy, and retinopathy of prematurity all disrupt retinal structure as a result of vessel growth and leakage...
  30. Ocular RTEF-1 Isoforms and Control of VEGF Expression: Implications for Therapy
    John T Stout; Fiscal Year: 2013
    ..gene within the eye leads to ocular neovascular disease, and included within this gamut of diseases is retinopathy of prematurity (ROP), retinal vascular occlusions (RVO), age-related macular degeneration (AMD) and diabetic ..
  31. Study of the RPE barrier
    Yun Zheng Le; Fiscal Year: 2013
    ..of BRBs is a major pathological change in age-related macular degeneration, diabetic retinopathy, retinopathy of prematurity, and uveitis...
  32. In Vivo Ocular Angiogenesis Assay
    WEN SENG; Fiscal Year: 2009
    ..Both conditions involve vascular abnormalities, proliferation and leakage of new blood vessels. Retinopathy of prematurity (ROP) is a major cause of newborn blindness in premature infants maintained by oxygen supplementation ..
  33. Training Program in the Molecular Bases of Eye Diseases
    PATRICIA ANN D'AMORE; Fiscal Year: 2013
    ..In addition, a variety of ocular pathologies are investigated such as macular degeneration, glaucoma, retinopathy of prematurity, corneal inflammation, wound healing, dry eye and corneal transplantation, among many others...
  34. HIF dysregulation as a novel genetic model to study retinal neovascular disease.
    AKRIT SINGH SODHI; Fiscal Year: 2013
    ..g. proliferative diabetic retinopathy, ischemic vascular occlusions, retinopathy of prematurity, and macular degeneration), these studies may promote a greater appreciation for the cause of other ..
  35. Circulating Immune Biomarkers and Retinopathy of Prematurity
    Olaf Dammann; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Retinopathy of prematurity (ROP) is a potentially preventable disorder of the retina that occurs predominantly in preterm newborns...
  36. A New Model for Eye Disease
    WEN SENG; Fiscal Year: 2009
    ..Both conditions involve vascular abnormalities, proliferation and leakage of new blood vessels. Retinopathy of prematurity (ROP) is a major cause of newborn blindness in premature infants maintained by oxygen supplementation ..
  37. Postnatal Growth and Retinopathy of Prematurity (G-ROP) Studies
    Gil Binenbaum; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Retinopathy of prematurity (ROP) is a leading cause of blindness in children...
  38. Potential target molecules for ischemic retinopathies
    GERARD ANTHONY LUTTY; Fiscal Year: 2011
    ..been identified as a key molecule in mediating the adverse effects of ischemic retinopathies such as DR, retinopathy of prematurity, and branch and central retinal vein occlusions, but PIGF and TNFa have been shown to potentiate the ..
  39. Complement Mediated Neovascularization in Retinopathy
    Kip M Connor; Fiscal Year: 2013
    Pathological neovascularization is a hallmark of retinopathy of prematurity (ROP) and diabetic retinopathy (DR), where the balance between neovessel formation and regression determines disease severity...
  40. PHOTORECEPTOR FUNCTION IN RETINOPATHY OF PREMATURITY
    Anne B Fulton; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Retinopathy of prematurity (ROP) remains the most frequent ocular cause of pediatric bilateral visual impairment...
  41. Regulating retinal microvascular morphogenesis
    Ira M Herman; Fiscal Year: 2010
    ..development, post-natally and in association with several visually-impairing diseases, including retinopathy of prematurity (ROP), age-related macular degeneration and diabetic retinopathy...
  42. THE IMPORTANCE OF MACROPHAGE SENESCENCE IN REGULATING ANGIOGENESIS IN THE EYE
    Rajendra S Apte; Fiscal Year: 2013
    ..in several disease states of the eye, including age-related macular degeneration, diabetic retinopathy, retinopathy of prematurity, and intraocular tumors...
  43. Eyes Absent phosphatase inhibitors in eye disease
    Richard A Lang; Fiscal Year: 2010
    ..These include retinopathy of prematurity (ROP), age-related macular degeneration (AMD) and diabetic retinopathy (DR)...
  44. Telemedicine Approaches to Evaluating Acute-phase ROP - eROP
    Graham E Quinn; Fiscal Year: 2013
    ..RELEVANCE (See instructions): Retinopathy of prematurity (ROP) is the leading cause of treatable childhood blindness...
  45. Automated retinopathy of prematurity classification using machine learning
    Jayashree Kalpathy-Cramer; Fiscal Year: 2013
    ..The goal of this project is to develop a web-based, semi-automated system for identifying severe retinopathy of prematurity (ROP) with "plus disease," using an existing data set of retinal images collected from previous NIH- ..
  46. Retinal Microglia and Angiogenesis
    Richard A Lang; Fiscal Year: 2013
    ..In particular, this work has implications for the vision-compromising ailments diabetic retinopathy, age-related macular degeneration and retinopathy of prematurity.
  47. Retinovascular pathophysiology: focus on proliferative retinopathy
    Donald G Puro; Fiscal Year: 2013
    ..the pathophysiology of proliferative retinopathy, which is a sight-threatening complication of diabetes, retinopathy of prematurity and other important disorders...
  48. Clinical and Genetic Analysis of Retinopathy of Prematurity
    Michael Chiang; Fiscal Year: 2012
    The long-term goal of this project is to identify clinical and genetic features of retinopathy of prematurity (ROP) development, and to analyze their relationships...
  49. Induction of the blood-retinal barrier
    DAVID ANTONETTI; Fiscal Year: 2010
    ..is essential for normal retinal function and loss of this barrier contributes to the pathophysiology of retinopathy of prematurity, diabetic retinopathy, age related macular degeneration and other retinal diseases...
  50. EARLY TMT/RETINOPATHY OF PREMATURITY (ETROP)- COORD CTR
    Robert Hardy; Fiscal Year: 2009
    b>Retinopathy of prematurity (ROP) is a potentially blinding disease of premature infants in which retinal blood vessels fail to develop properly...
  51. Placenta bacteriology and histology in the etiology of retinopathy of prematurity
    Olaf Dammann; Fiscal Year: 2010
    ..born preterm by providing solid data support about potentially preventable antenatal risk factors of retinopathy of prematurity (ROP) derived from placenta bacteriology and histology...
  52. CAN CD 133 CELLS PREVENT HYPOXIA DRIVEN RETINAL NEOVASCULARISATION IN A RODENT MO
    Bela Anand Apte; Fiscal Year: 2007
    ..Retinal neovascularization is observed in ischemic retinopathies such as diabetic retinopathy, retinopathy of prematurity, central vein occlusion and branch retinal vein occlusion...
  53. Quantum Dot-Based Profile Imaging of EPC Subpopulations and Effect on Retinal NV
    JOSHUA MCALISTER BARNETT; Fiscal Year: 2010
    ..the neovascular capacity of various endothelial progenitor subsets using an established animal model of retinopathy of prematurity, in conjunction with a real-time, multispectral, quantum dot nanocrystalbased imaging system which ..
  54. COST EFFECTIVENESS OF EYE RESEARCH AND CARE
    Jonathan Javitt; Fiscal Year: 1993
    ..to test the hypothesis that the implementation of treatment based upon results of clinical trials in retinopathy of prematurity, diabetic retinopathy, and glaucoma benefit not only the patient, but result in net societal savings as ..
  55. BETA 1 INTEGRIN ANTAGONISM & RETINAL NEOVASCULARIZATION
    DONALD SENGER; Fiscal Year: 2001
    ..that leads to blindness in patients with diabetic retinopathy, age-related macular degeneration, and retinopathy of prematurity. Vascular endothelial growth factor (VEGF), a potent hypoxia-inducible angiogenic cytokine, has been ..
  56. STOP-ROP--A MULTICENTER TRIAL OF OXYGEN FOR ROP
    DALE PHELPS; Fiscal Year: 2001
    b>Retinopathy of Prematurity (ROP) remains a serious public health problem causing significant visual sequelae in an estimated 2,060 premature survivors per year in the United States or 4,400 without the benefits of Cryotherapy...
  57. Adaptive Optics Imager for Study of Pediatric Retinal Disorders
    Anne Fulton; Fiscal Year: 2009
    ..It is well established that retinopathy of prematurity (ROP), and even premature birth alone, alters the neural and vascular elements of the retina, but there ..
  58. ADENOSINE RECEPTORS TO INHIBIT RETINAL ANGIOGENESIS
    Luiz Belardinelli; Fiscal Year: 2000
    Microvascular abnormalities of the retina, such as retinopathy of prematurity, macular degeneration and diabetic retinopathy are among the leading causes of non-traumatic blindness...
  59. EFFECT OF LIGHT REDUCTION ON RETINOPATHY OF PREMATURITY
    Rand Spencer; Fiscal Year: 1990
    ..applications for financial support to plan multi-protocol clinical-epidemiologic research involving retinopathy of prematurity (ROP)...
  60. INDUCED APOPTOSIS IN AGE RELATED MACULAR DEGENERATION
    Thomas Ferguson; Fiscal Year: 2002
    ..cause of vision loss in patients with age- related macular degeneration (AMD), diabetic retinopathy, and retinopathy of prematurity. AMD is the leading cause of blindness in the Western world in individuals over 60 years of age...
  61. A new approach to the treatment of Retinopathy of Prematurity
    Paul A Yates; Fiscal Year: 2013
    The long term objective of this application is to develop new treatments for retinopathy of prematurity (ROP), the leading cause of childhood blindness...
  62. THERAPEUTIC OXYGEN IN ROP
    DALE PHELPS; Fiscal Year: 1990
    ..interrelated applications for financial support to plan multiprotocol clinical-epidemiologic research in retinopathy of prematurity (ROP)...
  63. ANIMAL MODEL FOR RETINOPATHY OF PREMATURITY
    John Penn; Fiscal Year: 1992
    ..research seeks to characterize oxygen-induced retinopathy (OIR) in the rat as an animal model for retinopathy of prematurity (ROP)...
  64. Role of ADAMs 9 and 15 in Proliferative Retinopathy
    Carl Blobel; Fiscal Year: 2009
    ..have shown that adam 15-/- mice have strongly decreased pathological neovascularization in a model for retinopathy of prematurity (ROP model), whereas adam 9-/- mice, and adam 9/15-/- double knockout mice have strongly increased ..