macular degeneration

Summary

Summary: Degenerative changes in the macula lutea of the retina.

Top Publications

  1. ncbi Ranibizumab for neovascular age-related macular degeneration
    Philip J Rosenfeld
    Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    N Engl J Med 355:1419-31. 2006
  2. ncbi Age-related macular degeneration
    Laurence S Lim
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Lancet 379:1728-38. 2012
  3. pmc Ranibizumab and bevacizumab for neovascular age-related macular degeneration
    Daniel F Martin
    N Engl J Med 364:1897-908. 2011
  4. pmc Mechanisms of age-related macular degeneration
    Jayakrishna Ambati
    Department of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, KY 40506, USA
    Neuron 75:26-39. 2012
  5. pmc Complement factor H polymorphism in age-related macular degeneration
    Robert J Klein
    Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 308:385-9. 2005
  6. pmc Seven new loci associated with age-related macular degeneration
    Lars G Fritsche
    Institute of Human Genetics, University of Regensburg, Regensburg, Germany
    Nat Genet 45:433-9, 439e1-2. 2013
  7. ncbi Ranibizumab versus verteporfin for neovascular age-related macular degeneration
    David M Brown
    Vitreoretinal Consultants, Methodist Hospital, Houston, TX 77030, USA
    N Engl J Med 355:1432-44. 2006
  8. ncbi Embryonic stem cell trials for macular degeneration: a preliminary report
    Steven D Schwartz
    Jules Stein Eye Institute Retina Division, Department of Ophthalmology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Lancet 379:713-20. 2012
  9. doi Age-related macular degeneration
    Rama D Jager
    Section of Ophthalmology and Visual Science, Department of Surgery, University of Chicago, Chicago, USA
    N Engl J Med 358:2606-17. 2008
  10. ncbi An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration
    G S Hageman
    Department of Ophthalmology and Visual Sciences, The University of Iowa Center for Macular Degeneration, PFP 11190E, 200 Hawkins Drive, The University of Iowa, Iowa City, IA 52240, USA
    Prog Retin Eye Res 20:705-32. 2001

Detail Information

Publications311 found, 100 shown here

  1. ncbi Ranibizumab for neovascular age-related macular degeneration
    Philip J Rosenfeld
    Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    N Engl J Med 355:1419-31. 2006
    Ranibizumab--a recombinant, humanized, monoclonal antibody Fab that neutralizes all active forms of vascular endothelial growth factor A--has been evaluated for the treatment of neovascular age-related macular degeneration.
  2. ncbi Age-related macular degeneration
    Laurence S Lim
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Lancet 379:1728-38. 2012
    Age-related macular degeneration is a major cause of blindness worldwide. With ageing populations in many countries, more than 20% might have the disorder...
  3. pmc Ranibizumab and bevacizumab for neovascular age-related macular degeneration
    Daniel F Martin
    N Engl J Med 364:1897-908. 2011
    Clinical trials have established the efficacy of ranibizumab for the treatment of neovascular age-related macular degeneration (AMD). In addition, bevacizumab is used off-label to treat AMD, despite the absence of similar supporting data.
  4. pmc Mechanisms of age-related macular degeneration
    Jayakrishna Ambati
    Department of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, KY 40506, USA
    Neuron 75:26-39. 2012
    Age-related macular degeneration (AMD), a progressive condition that is untreatable in up to 90% of patients, is a leading cause of blindness in the elderly worldwide...
  5. pmc Complement factor H polymorphism in age-related macular degeneration
    Robert J Klein
    Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 308:385-9. 2005
    Age-related macular degeneration (AMD) is a major cause of blindness in the elderly. We report a genome-wide screen of 96 cases and 50 controls for polymorphisms associated with AMD...
  6. pmc Seven new loci associated with age-related macular degeneration
    Lars G Fritsche
    Institute of Human Genetics, University of Regensburg, Regensburg, Germany
    Nat Genet 45:433-9, 439e1-2. 2013
    Age-related macular degeneration (AMD) is a common cause of blindness in older individuals...
  7. ncbi Ranibizumab versus verteporfin for neovascular age-related macular degeneration
    David M Brown
    Vitreoretinal Consultants, Methodist Hospital, Houston, TX 77030, USA
    N Engl J Med 355:1432-44. 2006
    ..monoclonal antibody Fab that neutralizes all active forms of vascular endothelial growth factor A--with photodynamic therapy with verteporfin in the treatment of predominantly classic neovascular age-related macular degeneration.
  8. ncbi Embryonic stem cell trials for macular degeneration: a preliminary report
    Steven D Schwartz
    Jules Stein Eye Institute Retina Division, Department of Ophthalmology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Lancet 379:713-20. 2012
    ..It has been 13 years since the discovery of human embryonic stem cells (hESCs). Our report provides the first description of hESC-derived cells transplanted into human patients...
  9. doi Age-related macular degeneration
    Rama D Jager
    Section of Ophthalmology and Visual Science, Department of Surgery, University of Chicago, Chicago, USA
    N Engl J Med 358:2606-17. 2008
  10. ncbi An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration
    G S Hageman
    Department of Ophthalmology and Visual Sciences, The University of Iowa Center for Macular Degeneration, PFP 11190E, 200 Hawkins Drive, The University of Iowa, Iowa City, IA 52240, USA
    Prog Retin Eye Res 20:705-32. 2001
    Age-related macular degeneration (AMD) is a blinding disease that afflicts millions of adults in the Western world...
  11. pmc The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited
    Don H Anderson
    Center for the Study of Macular Degeneration, Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA
    Prog Retin Eye Res 29:95-112. 2010
    ..During the past ten years, dramatic advances have been made in unraveling the biological bases of age-related macular degeneration (AMD), the most common cause of irreversible blindness in western populations...
  12. pmc Consequences of oxidative stress in age-related macular degeneration
    Stuart G Jarrett
    Department of Molecular and Biomedical Pharmacology, College of Medicine, University of Kentucky, Lexington, KY, USA
    Mol Aspects Med 33:399-417. 2012
    ..It appears that these age-related oxidative changes are a hallmark of early age-related macular degeneration (AMD) which, in combination with hereditary susceptibility and other retinal modifiers, can progress to the ..
  13. pmc Drusen proteome analysis: an approach to the etiology of age-related macular degeneration
    John W Crabb
    Cole Eye Institute and Lerner Research Institute, Cleveland Clinic Foundation, and Department of Chemistry, Case Western Reserve University, OH 44195, USA
    Proc Natl Acad Sci U S A 99:14682-7. 2002
    ..below the retinal pigment epithelium on Bruch's membrane and are risk factors for developing age-related macular degeneration (AMD). The progression of AMD might be slowed or halted if the formation of drusen could be modulated...
  14. ncbi Complement factor H variant increases the risk of age-related macular degeneration
    Jonathan L Haines
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Science 308:419-21. 2005
    Age-related macular degeneration (AMD) is a leading cause of visual impairment and blindness in the elderly whose etiology remains largely unknown. Previous studies identified chromosome 1q32 as harboring a susceptibility locus for AMD...
  15. ncbi Complement factor H binds malondialdehyde epitopes and protects from oxidative stress
    David Weismann
    Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria
    Nature 478:76-81. 2011
    ..and enhanced lipid peroxidation are linked to many chronic inflammatory diseases, including age-related macular degeneration (AMD)...
  16. pmc Understanding age-related macular degeneration (AMD): relationships between the photoreceptor/retinal pigment epithelium/Bruch's membrane/choriocapillaris complex
    Imran Bhutto
    Wilmer Ophthalmological Institute, Johns Hopkins Hospital, Baltimore, MD 21287 9115, USA
    Mol Aspects Med 33:295-317. 2012
    ..Loss of this functionally integrated relationship results in death and dysfunction of all of the components in the complex...
  17. pmc Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration
    Yi Yu
    Ophthalmic Epidemiology and Genetics Service, New England Eye Center, Tufts Medical Center, Tufts University School of Medicine, 800 WashingtonStreet, No 450, Boston, MA 02111, USA
    Hum Mol Genet 20:3699-709. 2011
    Despite significant progress in the identification of genetic loci for age-related macular degeneration (AMD), not all of the heritability has been explained...
  18. pmc DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration
    Hiroki Kaneko
    Department of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, Kentucky 40506, USA
    Nature 471:325-30. 2011
    Geographic atrophy (GA), an untreatable advanced form of age-related macular degeneration, results from retinal pigmented epithelium (RPE) cell degeneration...
  19. ncbi Ranibizumab versus verteporfin photodynamic therapy for neovascular age-related macular degeneration: Two-year results of the ANCHOR study
    David M Brown
    Vitreoretinal Consultants, Methodist Hospital, Houston, Texas 77030, USA
    Ophthalmology 116:57-65.e5. 2009
    ..Antibody for the Treatment of Predominantly Classic Choroidal Neovascularization (CNV) in Age-related Macular Degeneration (ANCHOR) compared ranibizumab with verteporfin photodynamic therapy (PDT) in treating predominantly classic ..
  20. ncbi An optical coherence tomography-guided, variable dosing regimen with intravitreal ranibizumab (Lucentis) for neovascular age-related macular degeneration
    Anne E Fung
    Pacific Eye Associates, California Pacific Medical Center, San Francisco, California, USA
    Am J Ophthalmol 143:566-83. 2007
    To evaluate an optical coherence tomography (OCT)-guided, variable-dosing regimen with intravitreal ranibizumab for the treatment of patients with neovascular age-related macular degeneration (AMD).
  21. ncbi Complement factor H polymorphism and age-related macular degeneration
    Albert O Edwards
    Department of Ophthalmology and McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center UTSWMC, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Science 308:421-4. 2005
    Age-related macular degeneration (AMD) is a common, late-onset, and complex trait with multiple risk factors...
  22. ncbi Para-inflammation in the aging retina
    Heping Xu
    Immunology and Infection, Division of Applied Medicine, University of Aberdeen School of Medicine, Foresterhill, UK
    Prog Retin Eye Res 28:348-68. 2009
    ..para-inflammation to various pathological conditions is essential for the better understanding of the pathogenesis of various age-related retinal diseases including diabetic retinopathy, glaucoma and age-related macular degeneration.
  23. ncbi Prevalence of age-related macular degeneration in the United States
    David S Friedman
    Wilmer Eye Institute, Wilmer 120, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Arch Ophthalmol 122:564-72. 2004
    To estimate the prevalence and distribution of age-related macular degeneration (AMD) in the United States by age, race/ethnicity, and gender.
  24. ncbi Causes and prevalence of visual impairment among adults in the United States
    Nathan Congdon
    Wilmer Eye Institute, Wilmer 120, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Arch Ophthalmol 122:477-85. 2004
    ..To estimate the cause-specific prevalence and distribution of blindness and low vision in the United States by age, race/ethnicity, and gender, and to estimate the change in these prevalence figures over the next 20 years...
  25. ncbi Age-related macular degeneration
    Paulus T V M De Jong
    Department of Ophthalmogenetics, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands
    N Engl J Med 355:1474-85. 2006
  26. pmc Molecular pathology of age-related macular degeneration
    Xiaoyan Ding
    Immunopathology Section, Laboratory of Immunology, National Eye Institute, Bethesda, MD 20892 1857, USA
    Prog Retin Eye Res 28:1-18. 2009
    Age-related macular degeneration (AMD) is a leading cause of irreversible blindness in the world...
  27. pmc CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration
    Christophe Combadiere
    INSERM U543, Laboratoire d Immunologie Cellulaire, Paris, France
    J Clin Invest 117:2920-8. 2007
    The role of retinal microglial cells (MCs) in age-related macular degeneration (AMD) is unclear...
  28. ncbi Prevention of age-related macular degeneration-like retinopathy by rapamycin in rats
    Nataliya G Kolosova
    Institute of Cytology and Genetics, The Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia
    Am J Pathol 181:472-7. 2012
    Age-related macular degeneration, a neurodegenerative and vascular retinal disease, is the most common cause of blindness in the Western countries...
  29. pmc Oxidative damage-induced inflammation initiates age-related macular degeneration
    Joe G Hollyfield
    Cole Eye Institute i31, Department of Ophthalmology, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio 44195, USA
    Nat Med 14:194-8. 2008
    Oxidative damage and inflammation are postulated to be involved in age-related macular degeneration (AMD). However, the molecular signal(s) linking oxidation to inflammation in this late-onset disease is unknown...
  30. ncbi Clinical classification of age-related macular degeneration
    Frederick L Ferris
    Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1204, USA
    Ophthalmology 120:844-51. 2013
    To develop a clinical classification system for age-related macular degeneration (AMD).
  31. pmc The estimated prevalence and incidence of late stage age related macular degeneration in the UK
    Christopher G Owen
    Division of Population Health Sciences and Education, St George s, University of London, Cranmer Terrace, London SW17 0RE, UK
    Br J Ophthalmol 96:752-6. 2012
    UK estimates of age related macular degeneration (AMD) occurrence vary.
  32. pmc The oil spill in ageing Bruch membrane
    Christine A Curcio
    Department of Ophthalmology, EyeSight Foundation of Alabama Vision Science Laboratories Room 360, University of Alabama School of Medicine, Birmingham, AL 35294 0019, USA
    Br J Ophthalmol 95:1638-45. 2011
    Ageing is the largest risk factor for age-related macular degeneration (AMD), and soft drusen and basal linear deposits are lipid-rich extracellular lesions specific to AMD...
  33. pmc Vascular endothelial growth factor-A is a survival factor for retinal neurons and a critical neuroprotectant during the adaptive response to ischemic injury
    Kazuaki Nishijima
    R and D Consultants, Barnet, Herts, UK
    Am J Pathol 171:53-67. 2007
    ..These findings have implications for both neural pathologies and ocular vascular diseases, such as diabetic retinopathy and age-related macular degeneration.
  34. pmc A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration
    Gregory S Hageman
    Department of Ophthalmology and Visual Sciences, Cell Biology and Functional Genomics Laboratory, University of Iowa, Iowa City, IA 52240, USA
    Proc Natl Acad Sci U S A 102:7227-32. 2005
    Age-related macular degeneration (AMD) is the most frequent cause of irreversible blindness in the elderly in developed countries...
  35. pmc Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration
    Wei Chen
    Center for Statistical Genetics, Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 107:7401-6. 2010
    We executed a genome-wide association scan for age-related macular degeneration (AMD) in 2,157 cases and 1,150 controls...
  36. ncbi Age-related macular degeneration--emerging pathogenetic and therapeutic concepts
    Karen M Gehrs
    Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, IA 52240, USA
    Ann Med 38:450-71. 2006
    ..often significantly diminished by the effects of age-related, degenerative diseases, including age-related macular degeneration (AMD), the leading cause of blindness in the elderly worldwide...
  37. ncbi A role for local inflammation in the formation of drusen in the aging eye
    Don H Anderson
    Center for the Study of Macular Degeneration, Neuroscience Research Institute, University of California, Santa Barbara 93106, USA
    Am J Ophthalmol 134:411-31. 2002
    ..confluent drusen, especially in the macula, is a significant risk factor for the development of age-related macular degeneration (AMD)...
  38. pmc Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC)
    Benjamin M Neale
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 107:7395-400. 2010
    Advanced age-related macular degeneration (AMD) is the leading cause of late onset blindness. We present results of a genome-wide association study of 979 advanced AMD cases and 1,709 controls using the Affymetrix 6...
  39. pmc Hypomethylation of the IL17RC promoter associates with age-related macular degeneration
    Lai Wei
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Rep 2:1151-8. 2012
    Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly population worldwide...
  40. pmc Common polymorphisms in C3, factor B, and factor H collaborate to determine systemic complement activity and disease risk
    Meike Heurich
    Department of Infection, Immunity and Biochemistry, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom
    Proc Natl Acad Sci U S A 108:8761-6. 2011
    ..AP) proteins C3 (C3(R102G)), factor B (fB(R32Q)), and factor H (fH(V62I)) are associated with age-related macular degeneration (AMD) and other pathologies...
  41. ncbi Oxidative stress activates NLRP3 inflammasomes in ARPE-19 cells--implications for age-related macular degeneration (AMD)
    Anu Kauppinen
    Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, P O Box 1627, FIN 70211 Kuopio, Finland
    Immunol Lett 147:29-33. 2012
    Oxidative stress and inflammation are known to be associated with age-related macular degeneration (AMD)...
  42. ncbi Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degeneration: the Veterans LAST study (Lutein Antioxidant Supplementation Trial)
    Stuart Richer
    Department of Veterans Affairs, Medical Center Eye Clinic, North Chicago, Illinois 60064 3095, USA
    Optometry 75:216-30. 2004
    Age-related macular degeneration (ARMD) is the leading cause of vision loss in aging Westem societies...
  43. ncbi Randomized, double-masked, sham-controlled trial of ranibizumab for neovascular age-related macular degeneration: PIER Study year 1
    Carl D Regillo
    Retina Service, Wills Eye Institute, 840 Walnut Street, Philadelphia, PA 19107, USA
    Am J Ophthalmol 145:239-248. 2008
    To evaluate the efficacy and safety of ranibizumab administered monthly for three months and then quarterly in patients with subfoveal choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD).
  44. ncbi Molecular mechanisms of retinal pigment epithelium damage and development of age-related macular degeneration
    Kati Kinnunen
    Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
    Acta Ophthalmol 90:299-309. 2012
    Age-related macular degeneration (AMD) is attributed to a complex interaction of genetic and environmental factors...
  45. ncbi A variable-dosing regimen with intravitreal ranibizumab for neovascular age-related macular degeneration: year 2 of the PrONTO Study
    Geeta A Lalwani
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Am J Ophthalmol 148:43-58.e1. 2009
    ..with ranibizumab in the Prospective Optical Coherence Tomography (OCT) Imaging of Patients with Neovascular Age-Related Macular Degeneration (AMD) Treated with intraOcular Ranibizumab (PrONTO) Study, patients were followed for 2 years.
  46. pmc Age-related macular degeneration: genetic and environmental factors of disease
    Yuhong Chen
    Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Fudan University, Shanghai, China
    Mol Interv 10:271-81. 2010
    Age-related macular degeneration (AMD) is the most common cause of visual impairment among the elderly in developed countries, and its prevalence is thus increasing as the population ages; however, treatment options remain limited because ..
  47. ncbi A Phase IIIb study to evaluate the safety of ranibizumab in subjects with neovascular age-related macular degeneration
    David S Boyer
    Retina Vitreous Associates Medical Group, 1127 Wilshire Boulevard, Los Angeles, CA 90017, USA
    Ophthalmology 116:1731-9. 2009
    To evaluate the safety and efficacy of intravitreal ranibizumab in a large population of subjects with neovascular age-related macular degeneration (AMD).
  48. ncbi The epidemiology of age-related macular degeneration
    Ronald Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53726, USA
    Am J Ophthalmol 137:486-95. 2004
    To review the epidemiology of age-related macular degeneration (AMD).
  49. pmc Age-related macular degeneration
    Hanna R Coleman
    Division of Epidemiology and Clinical Research, National Eye Institute, National Institutes of Health, Bethesda, MD, USA
    Lancet 372:1835-45. 2008
    Age-related macular degeneration is the leading cause of blindness in elderly populations of European descent. The most consistent risk factors associated with this ocular condition are increasing age and cigarette smoking...
  50. ncbi A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration
    Anne E Hughes
    Department of Medical Genetics, Queen s University, Belfast, Belfast BT12 6BL, UK
    Nat Genet 38:1173-7. 2006
    Age-related macular degeneration (AMD; OMIM #603075) is the most frequent cause of visual impairment in the elderly population, with severe disease affecting nearly 10% of individuals of European descent over the age of 75 years...
  51. pmc Mitochondrial DNA damage as a potential mechanism for age-related macular degeneration
    Pabalu P Karunadharma
    Department of Ophthalmology, University of Minnesota Twin Cities, Minneapolis, Minnesota 55455, USA
    Invest Ophthalmol Vis Sci 51:5470-9. 2010
    Increasing evidence suggests a central role for mitochondrial (mt) dysfunction in age-related macular degeneration (AMD)...
  52. ncbi Effects of lutein supplementation on macular pigment optical density and visual acuity in patients with age-related macular degeneration
    Günther Weigert
    Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
    Invest Ophthalmol Vis Sci 52:8174-8. 2011
    ..In addition, an investigation was conducted into whether lutein supplementation improves visual acuity (VA) and macular function (mean differential light threshold; MDLT), as assessed with microperimetry...
  53. ncbi Age-related macular degeneration (AMD): pathogenesis and therapy
    Jerzy Z Nowak
    Department of Pharmacology, Medical University, Zeligowskiego 7 9, PL 90 752 Łódź, Poland
    Pharmacol Rep 58:353-63. 2006
    Age-related macular degeneration (AMD) is a disease leading to severe visual loss and legal blindness in the elderly population...
  54. ncbi Age-related macular degeneration (AMD): Alzheimer's disease in the eye?
    Kai Kaarniranta
    Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
    J Alzheimers Dis 24:615-31. 2011
    Age-related macular degeneration (AMD) is a late-onset, neurodegenerative retinal disease that shares several clinical and pathological features with Alzheimer's disease (AD), including stress stimuli such as oxidative stress and ..
  55. ncbi Complement C3 variant and the risk of age-related macular degeneration
    John R W Yates
    Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    N Engl J Med 357:553-61. 2007
    Age-related macular degeneration is the most common cause of blindness in Western populations. Susceptibility is influenced by age and by genetic and environmental factors. Complement activation is implicated in the pathogenesis.
  56. ncbi The role of apoptosis in age-related macular degeneration
    Joshua L Dunaief
    305 Stellar Chance Labs, University of Pennsylvania, Philadelphia, PA 19104, USA
    Arch Ophthalmol 120:1435-42. 2002
    To investigate apoptosis in human age-related macular degeneration (AMD).
  57. pmc Impaired cholesterol efflux in senescent macrophages promotes age-related macular degeneration
    Abdoulaye Sene
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Cell Metab 17:549-61. 2013
    ..macrophages plays a central role in common age-associated diseases such as atherosclerosis, cancer, and macular degeneration. Here we demonstrate that abnormal polarization in older macrophages is caused by programmatic changes that ..
  58. ncbi Lutein: more than just a filter for blue light
    Aize Kijlstra
    University Eye Clinic Maastricht, Maastricht, The Netherlands
    Prog Retin Eye Res 31:303-15. 2012
    ..Whether lutein intake reduces the risk of age related macular degeneration (AMD) or cataract formation is currently a strong matter of debate and abundant research is carried out to ..
  59. pmc A rare penetrant mutation in CFH confers high risk of age-related macular degeneration
    Soumya Raychaudhuri
    Division of Genetics, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Nat Genet 43:1232-6. 2011
    ..1204C>T)(1-4) and the intronic rs1410996 SNP(5,6), explain 17% of age-related macular degeneration (AMD) liability...
  60. pmc Genetic insights into age-related macular degeneration: controversies addressing risk, causality, and therapeutics
    Michael B Gorin
    Department of Ophthalmology, David Geffen School of Medicine, UC, Los Angeles, CA, USA
    Mol Aspects Med 33:467-86. 2012
    Age-related macular degeneration (AMD) is a common condition among the elderly population that leads to the progressive central vision loss and serious compromise of quality of life for its sufferers...
  61. ncbi The impact of macular pigment augmentation on visual performance using different carotenoid formulations
    James Loughman
    Optometry Department, Dublin Institute of Technology, Dublin, Ireland
    Invest Ophthalmol Vis Sci 53:7871-80. 2012
    ..To investigate changes in macular pigment optical density (MPOD) and visual performance following supplementation with different macular carotenoid formulations...
  62. ncbi Association of age-related macular degeneration with polymorphisms in vascular endothelial growth factor and its receptor
    Alessandro Galan
    S Antonio Hospital, Department of Ophthalmology, Padova, Italy
    Ophthalmology 117:1769-74. 2010
    To analyze the association between age-related macular degeneration (AMD) and polymorphisms in vascular endothelial growth factor (VEGF) and VEGF receptor KDR gene polymorphisms...
  63. ncbi Development of ranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration
    Napoleone Ferrara
    Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Retina 26:859-70. 2006
    ..Among these, ranibizumab is a high affinity recombinant Fab that neutralizes all isoforms of VEGF-A. The article briefly reviews the biology of VEGF and then focuses on the path that led to clinical development of ranibizumab...
  64. ncbi Pegaptanib for neovascular age-related macular degeneration
    Evangelos S Gragoudas
    Retina Service, Massachusetts Eye and Ear Infirmary and Harvard Medical School, 243 Charles St, Boston, MA 02114, USA
    N Engl J Med 351:2805-16. 2004
    Pegaptanib, an anti-vascular endothelial growth factor therapy, was evaluated in the treatment of neovascular age-related macular degeneration.
  65. ncbi Prevalence of age-related macular degeneration in the US population
    Ronald Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, 610 N Walnut St, Room 417 WARF, Madison, WI 53726, USA
    Arch Ophthalmol 129:75-80. 2011
    To examine the prevalence of age-related macular degeneration (AMD) in non-Hispanic white, non-Hispanic black, Mexican American, and other racial/ethnic groups.
  66. ncbi Prevalence of age-related macular degeneration in 4 racial/ethnic groups in the multi-ethnic study of atherosclerosis
    Ronald Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin 53726 2336, USA
    Ophthalmology 113:373-80. 2006
    To describe the prevalence of age-related macular degeneration (AMD) in 4 racial/ethnic groups (white, black, Hispanic, and Chinese) that participated in the second examination of the Multi-ethnic Study of Atherosclerosis (MESA).
  67. ncbi Oxidative stress-induced mitochondrial DNA damage in human retinal pigment epithelial cells: a possible mechanism for RPE aging and age-related macular degeneration
    Fong Qi Liang
    Retina Foundation of the Southwest, Anderson Vision Research Center, 9900 N Central Expressway, Suite 400, Dallas, TX 75231, USA
    Exp Eye Res 76:397-403. 2003
    Oxidative stress is believed to contribute to the pathogenesis of many diseases, including age-related macular degeneration (AMD)...
  68. ncbi Activated microglia in human retinitis pigmentosa, late-onset retinal degeneration, and age-related macular degeneration
    Nisha Gupta
    Scheie Eye Institute, 51 North 39th Street, Philadelphia, PA 19104, USA
    Exp Eye Res 76:463-71. 2003
    ..in human retinas with retinitis pigmentosa (RP), late-onset retinal degeneration (L-ORD), or age-related macular degeneration (AMD)...
  69. pmc Clinical risk factors for age-related macular degeneration: a systematic review and meta-analysis
    Usha Chakravarthy
    Centre for Vision Science, Queen s University Belfast, Northern Ireland, UK
    BMC Ophthalmol 10:31. 2010
    Age-related macular degeneration (AMD) is the leading cause of blindness in Western countries. Numerous risk factors have been reported but the evidence and strength of association is variable...
  70. pmc Risk models for progression to advanced age-related macular degeneration using demographic, environmental, genetic, and ocular factors
    Johanna M Seddon
    Ophthalmic Epidemiology and Genetics Service, Tufts University School of Medicine and Tufts Medical Center, New England Eye Center, Boston, Massachusetts, USA
    Ophthalmology 118:2203-11. 2011
    To expand our predictive models for progression to advanced stages of age-related macular degeneration (AMD) based on demographic, environmental, genetic, and ocular factors, using longer follow-up, time varying analyses, calculation of ..
  71. pmc Drusen, choroidal neovascularization, and retinal pigment epithelium dysfunction in SOD1-deficient mice: a model of age-related macular degeneration
    Yutaka Imamura
    Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Proc Natl Acad Sci U S A 103:11282-7. 2006
    ..We show that mice deficient in Cu, Zn-superoxide dismutase (SOD1) have features typical of age-related macular degeneration in humans...
  72. ncbi Ranibizumab combined with verteporfin photodynamic therapy in neovascular age-related macular degeneration (FOCUS): year 2 results
    Andrew N Antoszyk
    Charlotte Eye, Ear, Nose and Throat Associates, Charlotte, North Carolina 28210, USA
    Am J Ophthalmol 145:862-74. 2008
    ..adverse-events profile of combined treatment with ranibizumab and verteporfin photodynamic therapy (PDT) in patients with predominantly classic choroidal neovascularization (CNV) secondary to neovascular age-related macular degeneration.
  73. ncbi Bayesian inference of epistatic interactions in case-control studies
    Yu Zhang
    Department of Statistics, The Pennsylvania State University, Thomas Building 422A, University Park, Pennsylvania 16802, USA
    Nat Genet 39:1167-73. 2007
    ..Testing this on an age-related macular degeneration genome-wide association data set, we demonstrate that the method is significantly more powerful than ..
  74. pmc Mitochondrial haplogroups and control region polymorphisms in age-related macular degeneration: a case-control study
    Edith E Mueller
    Research Program for Receptor Biochemistry and Tumor Metabolism, Department of Pediatrics, Paracelsus Medical University, Salzburg, Austria
    PLoS ONE 7:e30874. 2012
    Onset and development of the multifactorial disease age-related macular degeneration (AMD) are highly interrelated with mitochondrial functions such as energy production and free radical turnover...
  75. pmc Genome-wide analysis of copy number variants in age-related macular degeneration
    Kacie J Meyer
    Interdisciplinary Genetics Program, University of Iowa, Iowa City, IA 52242, USA
    Hum Genet 129:91-100. 2011
    Age-related macular degeneration (AMD) is a complex genetic disease, with many loci demonstrating appreciable attributable disease risk...
  76. pmc Endoplasmic reticulum stress in age-related macular degeneration: trigger for neovascularization
    Antero Salminen
    Department of Neurology, University of Eastern Finland, Kuopio, Finland
    Mol Med 16:535-42. 2010
    Age-related macular degeneration (AMD) can be classified into two main categories: the atrophic, dry form and the exudative, wet form...
  77. ncbi Choroidal thickness in polypoidal choroidal vasculopathy and exudative age-related macular degeneration
    Song Ee Chung
    Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Ophthalmology 118:840-5. 2011
    To compare choroidal thickness between eyes with polypoidal choroidal vasculopathy (PCV) and eyes with age-related macular degeneration (AMD).
  78. ncbi Age related macular degeneration and drusen: neuroinflammation in the retina
    Elisa Buschini
    NICO, Neuroscience Institute of the Cavalieri Ottolenghi Foundation, University of Torino, Regione Gonzole 10, Orbassano TO, Italy
    Prog Neurobiol 95:14-25. 2011
    ..Targeting these pathways could represent a new way to treat and prevent both exudative and dry forms of AMD...
  79. ncbi Efficacy and safety of monthly versus quarterly ranibizumab treatment in neovascular age-related macular degeneration: the EXCITE study
    Ursula Schmidt-Erfurth
    Department of Ophthalmology, University of Vienna, Waehringer Guertel, Vienna, Austria
    Ophthalmology 118:831-9. 2011
    To demonstrate noninferiority of a quarterly treatment regimen to a monthly regimen of ranibizumab in patients with subfoveal choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD).
  80. ncbi Randomized, double-masked, sham-controlled trial of ranibizumab for neovascular age-related macular degeneration: PIER study year 2
    Prema Abraham
    Black Hills Regional Eye Institute, 2800 Third Street, Rapid City, SD 57701, USA
    Am J Ophthalmol 150:315-324.e1. 2010
    ....
  81. ncbi Angiographic and optical coherence tomographic results of the MARINA study of ranibizumab in neovascular age-related macular degeneration
    Peter K Kaiser
    Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Ophthalmology 114:1868-75. 2007
    ..of minimally classic or occult with no classic choroidal neovascularization secondary to age-related macular degeneration (AMD) (designated MARINA [Minimally Classic/Occult Trial of the Anti-VEGF Antibody Ranibizumab in the ..
  82. pmc Preclinical aspects of anti-VEGF agents for the treatment of wet AMD: ranibizumab and bevacizumab
    C H Meyer
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Eye (Lond) 25:661-72. 2011
    ..growth factor (VEGF) therapies are currently used for the treatment of patients with wet age-related macular degeneration (AMD): pegaptanib, ranibizumab, and bevacizumab...
  83. pmc The drusenlike phenotype in aging Ccl2-knockout mice is caused by an accelerated accumulation of swollen autofluorescent subretinal macrophages
    Ulrich F O Luhmann
    Department of Genetics, UCL Institute of Ophthalmology, London, United Kingdom
    Invest Ophthalmol Vis Sci 50:5934-43. 2009
    ..are defined clinically as yellowish white spots in the outer retina, are cardinal features of age-related macular degeneration (AMD)...
  84. pmc Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: characterization, ethnic distribution and evolutionary implications
    Gregory S Hageman
    Department of Ophthalmology and Visual Sciences, Cell Biology and Functional Genomics Laboratory, The University of Iowa, 11190E PFP, 200 Hawkins Drive, Iowa City, Iowa 52240, USA
    Ann Med 38:592-604. 2006
    Variants in the complement factor H gene (CFH) are associated with age-related macular degeneration (AMD). CFH and five CFH-related genes (CFHR1-5) lie within the regulators of complement activation (RCA) locus on chromosome 1q32...
  85. pmc Variation near complement factor I is associated with risk of advanced AMD
    Jesen A Fagerness
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA
    Eur J Hum Genet 17:100-4. 2009
    A case-control association study for advanced age-related macular degeneration was conducted to explore several regions of interest identified by linkage...
  86. ncbi Smoking and age-related macular degeneration: a review of association
    J Thornton
    Evidence for Population Health Unit, Division of Epidemiology and Health Sciences, University of Manchester, Manchester, UK
    Eye (Lond) 19:935-44. 2005
    Age-related macular degeneration (AMD) is the leading cause of severe and irreversible vision loss in the Western world. As there is no effective treatment for all types of AMD, identifying modifiable risk factors is of great importance...
  87. pmc Mitochondrial DNA variants of respiratory complex I that uniquely characterize haplogroup T2 are associated with increased risk of age-related macular degeneration
    John Paul SanGiovanni
    National Eye Institute NEI National Institutes of Health NIH, Bethesda, Maryland, United States of America
    PLoS ONE 4:e5508. 2009
    Age-related macular degeneration (AMD), a chronic neurodegenerative and neovascular retinal disease, is the leading cause of blindness in elderly people of western European origin...
  88. ncbi The role of complement Factor H in age-related macular degeneration: a review
    Larry A Donoso
    The Philadelphia Retina Endowment Fund, the Eye Research Institute, Philadelphia, PA, USA
    Surv Ophthalmol 55:227-46. 2010
    ..polymorphisms) in Factor H have been implicated in a variety of human conditions including age-related macular degeneration (AMD), atypical hemolytic uremic syndrome, and membranoproliferative glomuleronephritis type II or dense ..
  89. pmc Localization of age-related macular degeneration-associated ARMS2 in cytosol, not mitochondria
    Gaofeng Wang
    Miami Institute for Human Genomics, University of Miami, Miami, Florida 33136, USA
    Invest Ophthalmol Vis Sci 50:3084-90. 2009
    To analyze the relationship between ARMS2 and HTRA1 in the association with age-related macular degeneration (AMD) in an independent case-control dataset and to investigate the subcellular localization of the ARMS2 protein in an in vitro ..
  90. ncbi Prevalence of age-related maculopathy in older Europeans: the European Eye Study (EUREYE)
    Cristina A Augood
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, England
    Arch Ophthalmol 124:529-35. 2006
    ..To estimate the prevalence of age-related maculopathy in an older population from 7 European countries...
  91. pmc Copy number variations in candidate genes in neovascular age-related macular degeneration
    Melissa M Liu
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA
    Invest Ophthalmol Vis Sci 52:3129-35. 2011
    The pathogenesis of age-related macular degeneration (AMD) is strongly influenced by genetic factors, and single nucleotide polymorphisms have been consistently linked to AMD...
  92. pmc A 32 kb critical region excluding Y402H in CFH mediates risk for age-related macular degeneration
    Theru A Sivakumaran
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS ONE 6:e25598. 2011
    Complement factor H shows very strong association with Age-related Macular Degeneration (AMD), and recent data suggest that multiple causal variants are associated with disease...
  93. ncbi Influence of saffron supplementation on retinal flicker sensitivity in early age-related macular degeneration
    Benedetto Falsini
    Dipartimento di Scienze Oftalmologiche e Otorinolaringologiche, Universita Cattolica del S Cuore, Rome, Italy
    Invest Ophthalmol Vis Sci 51:6118-24. 2010
    To evaluate the functional effect of short-term supplementation of saffron, a spice containing the antioxidant carotenoids crocin and crocetin, in early age-related macular degeneration (AMD).
  94. pmc Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration
    Jin Dong Ding
    Department of Ophthalmology, Duke Eye Center, Duke University, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 108:E279-87. 2011
    Age-related macular degeneration (AMD) is a leading cause of visual dysfunction worldwide. Amyloid β (Aβ) peptides, Aβ1-40 (Aβ40) and Aβ1-42 (Aβ42), have been implicated previously in the AMD disease process...
  95. pmc Immunopathological aspects of age-related macular degeneration
    Mrinali Patel
    Section of Immunopathology, Laboratory of Immunology, National Eye Institute, National Institutes of Health, 10 Center Drive, 10 10N103, NIH NEI, Bethesda, MD 20892 1857, USA
    Semin Immunopathol 30:97-110. 2008
    Age-related macular degeneration (AMD) represents a leading cause of blindness worldwide. While the clinical and histopathological aspects of AMD are well characterized, its etiology and pathogenesis remain unclear...
  96. ncbi Ranibizumab for predominantly classic neovascular age-related macular degeneration: subgroup analysis of first-year ANCHOR results
    Peter K Kaiser
    Cole Eye Institute, Cleveland, OH 44195, USA
    Am J Ophthalmol 144:850-857. 2007
    ..PDT) in patients with predominantly classic choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) were retrospectively analyzed to identify patient and disease characteristics that may predict visual ..
  97. ncbi Regulation of VEGF expression in human retinal cells by cytokines: implications for the role of inflammation in age-related macular degeneration
    Chandrasekharam N Nagineni
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Cell Physiol 227:116-26. 2012
    Chronic inflammation is implicated in the pathogenesis of age-related macular degeneration (AMD). Choroidal neovascularization (CNV) observed in exudative form of AMD results in vision loss...
  98. pmc Prediction model for prevalence and incidence of advanced age-related macular degeneration based on genetic, demographic, and environmental variables
    Johanna M Seddon
    Ophthalmic Epidemiology and Genetics Service, Tufts University School of Medicine and Tufts Medical Center, Boston, Massachusetts 02111, USA
    Invest Ophthalmol Vis Sci 50:2044-53. 2009
    ..The joint effects of genetic, ocular, and environmental variables were evaluated and predictive models for prevalence and incidence of AMD were assessed...
  99. ncbi Protective effect of complement factor B and complement component 2 variants in age-related macular degeneration
    Kylee L Spencer
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN, USA
    Hum Mol Genet 16:1986-92. 2007
    Age-related macular degeneration (AMD) is a devastating disorder of the central retina, causing significant visual impairment for 7.5 million elderly Americans...
  100. ncbi Phenotype and genotype characteristics of age-related macular degeneration in a Japanese population
    Keisuke Mori
    Department of Ophthalmology, Saitama Medical University, Iruma, Saitama, Japan
    Ophthalmology 117:928-38. 2010
    To describe phenotype and genotype characteristics of age-related macular degeneration (AMD) in Japanese patients.
  101. pmc Three major loci involved in age-related macular degeneration are also associated with polypoidal choroidal vasculopathy
    Luiz H Lima
    The Vitreous, Retina, Macula Consultants of New York and the LuEsther T Mertz Retina Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, USA
    Ophthalmology 117:1567-70. 2010
    To investigate the frequency of variants in 3 major age-related macular degeneration (AMD)-associated loci in patients of European-American descent with polypoidal choroidal vasculopathy (PCV).

Research Grants77

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..of Intravitreal Sirolimus in the Treatment of Bilateral Geographic Atrophy Associated with Age-Related Macular Degeneration Number: 11-EI-0249 Summary: Background: - Age-related macular degeneration (AMD) is a leading cause of ..
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..of Intravitreal Sirolimus in the Treatment of Bilateral Geographic Atrophy Associated with Age-Related Macular Degeneration Number: 11-EI-0249 Summary: Background: - Age-related macular degeneration (AMD) is a leading cause of ..
  3. Cystathionine beta synthase (CBS) and angiogenesis
    Priyabrata Mukherjee; Fiscal Year: 2013
    ..and neurovascular outcome due to CBS deficiency but combat angiogenesis dependent disorders such as macular degeneration, diabetic retinopathy, etc. as well...
  4. Prolonged Inhibition of Pathologic Neovascularization by Catalytic Antioxidants
    JAMES FRANCIS MCGINNIS; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): In some forms of Diabetic Retinopathy (DR) and Macular Degeneration (AMD), blindness results from the pathologic development of new blood vessels which are incomplete, weak and porous...
  5. Mechanism of action of omega-3 fatty acids in brain injury
    CHARLES NICHOLAS SERHAN; Fiscal Year: 2010
    ..is at the root of many chronic diseases, including coronary heart disease, diabetes, arthritis, obesity, macular degeneration, dry eye, osteoporosis, Alzheimer's disease and mental health disorders, and there is evidence from ..
  6. Therapeutic Effect of a Novel Antioxidant on Degenerative Eye Disorders
    Nuran Ercal; Fiscal Year: 2012
    ..damage in the pathogenesis of AREDs has been established for cataracts and the dry form of age-related macular degeneration (AMD)...
  7. Histone Chaperones in Angiogenesis
    Soumen Paul; Fiscal Year: 2012
    ..is also critical for certain pathological disorders including tumor growth/metastasis and age-related macular degeneration. Endothelial gene regulation is critical for blood vessel development and is also important during ..
  8. A Ribozyme Rescue Strategy for Dry Age-Related Macular Degeneration
    John M Sullivan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): In juvenile macular degeneration (JMD) (e...
  9. Cyr61/CCN1-Induced Angiogenesis and Vasculogenesis in the Retina
    Brahim Chaqour; Fiscal Year: 2010
    ..g., retinopathy of prematurity, age-related macular degeneration, diabetic retinopathy, etc)...
  10. Prevention of Retinal Degeneration by Crystallins in Experimental Uveitis
    Narsing A Rao; Fiscal Year: 2011
    ..Such oxidative damage has been implicated in various blinding diseases, including age-related macular degeneration, retinal vein occlusion, and glaucoma...
  11. Mitochondrial Oxidative Stress in the Retinal Pigment Epithelium as a Model for A
    Alfred S Lewin; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Age Related Macular Degeneration (AMD) is a major blinding disease of the elderly in this country and, while VEGF inhibitors often stem the late, exudative stages of the disease, there is no effective ..
  12. CCR3: a molecular marker for neovascular AMD
    Jayakrishna Ambati; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Age-related macular degeneration (AMD) affects as many Americans as all cancers combined and twice as many as Alzheimer's disease...
  13. Familial and Birth Cohort Effects on the Aging Senses
    Karen J Cruickshanks; Fiscal Year: 2013
    ..the 5-year incidence of hearing, vision, and olfactory impairments, sensory co-morbidity and age-related macular degeneration in the Beaver Dam Offspring Study (BOSS) cohort, the associations of potential risk factors with these ..
  14. Genetically testing interactions of ER and oxidative stresses in retinal disease
    Douglas Gould; Fiscal Year: 2013
    ..the type IV collagen alpha 1 gene (Col4a1) gene cause retinal phenotypes in mice that resemble age-related macular degeneration (AMD)...
  15. Endothelial Cell Dysregulation in Neovascular AMD
    Mark E Kleinman; Fiscal Year: 2013
    ..dysregulation, immuno-modulation in vascular growth, and therapeutic targets in neovascular age-related macular degeneration (AMD)...
  16. Astrocyte Development and Reactive Gliosis
    Teri L Belecky-Adams; Fiscal Year: 2012
    ..Reactive glia are present in many eye diseases, including glaucoma, age-related macular degeneration, retinitis pigmentosa, diabetic retinopathy and retinopathy of prematurity...
  17. Vision Sciences Training Grant
    Carol A Mason; Fiscal Year: 2013
    ..retinoid processing, and the genetics, diagnostics and therapy of retinal disorders, with a focus on macular degeneration, retinitis pigmentosa, diabetic retinopathy, and retinopathy of prematurity...
  18. Gross Hall Animal Resource Center
    Susan V Bryant; Fiscal Year: 2010
    ..medicine, Alzheimer's disease, cancer, diabetes and other metabolic disorders, immunology, macular degeneration, retinitis pigmentosa, herpes-related blindness, spinal cord injury, and stroke...
  19. Gene Therapy for Retinitis Pigmentosa
    Rajendra Kumar-Singh; Fiscal Year: 2012
    ..tools developed in this study will also have application in developing therapies for diabetic retinopathy, age related macular degeneration, glaucoma etc., that are collectively the most common causes of blindness in the United States.
  20. CYP1B1, NF-kB , and Regulation of Angiogenesis
    TAMMY LYNN PALENSKI; Fiscal Year: 2012
    ..with pathogenesis many diseases including retinopathy of prematurity, diabetic retinopathy and age-related macular degeneration. This is generally accomplished by down-regulation of negative and up-regulation of positive regulators of ..
  21. C3, CR1, CRRY: INTERACTIONS, HOMEOSTASIS AND TRANSLATIONAL IMPLICATIONS
    JOHN PATTERSON ATKINSON; Fiscal Year: 2013
    ..in the brain (Alzheimer's disease - AD) and lipofuscin pigments (drusen) in the retina (age-related macular degeneration - AMD)...
  22. Circadian Rhythm in Cone Photoreceptors: Cellular Mechanisms
    GLADYS Y KO; Fiscal Year: 2012
    ..since there is no treatment to reverse photoreceptor death associated with ocular diseases such as Macular Degeneration (MD), the leading cause of vision impairment and blindness...
  23. Gene therapy to support cone metabolism in retinitis pigmentosa
    Constance L Cepko; Fiscal Year: 2013
    ..If such therapies can be developed, it is also possible that these therapies can be extended to other diseases where cones are compromised, such as age-related macular degeneration (AMD).
  24. 2011 Nucleic Acids Gordon Research Conference
    Christopher D Lima; Fiscal Year: 2011
    ..discussed at the Nucleic Acids GRC, specifically RNAi therapeutics, are currently in clinical trials for macular degeneration and hepatitis C...
  25. Toll-Like Receptor-Mediated Photoreceptor Mitochondrial DNA Damage
    Narsing A Rao; Fiscal Year: 2010
    ..in the pathogenesis of CNS demyelination, ischemia/reperfusion injury of the organs, and age-related macular degeneration. In this application, TLR4 induced by heat-killed mycobacteria injected at distant sites initiates neuronal ..
  26. RPE Phenotype and Oxidative Stress
    Janice M Burke; Fiscal Year: 2013
    ..by applicant): Oxidative stress is implicated in virtually every disease of aging, including age-related macular degeneration. However, exactly how oxidative stress contributes to age-related disease in different tissues is poorly ..
  27. DEVELOPMENT AND MAINTENANCE OF LENS TRANSPARENCY
    JOHN IRWIN CLARK; Fiscal Year: 2013
    ..and amyloid/aggregate formation characterize disorders of aging that include cataract, age related macular degeneration (AMD), neurodegeneration, cardiomyopathy and muscular dystrophy...
  28. BIOCHEMISTRY AND PHARMACOLOGY OF THE MACULAR CAROTENOIDS
    PAUL STEVEN BERNSTEIN; Fiscal Year: 2013
    ..they are thought to provide protection against degenerative diseases of the retina including age-related macular degeneration (AMD) by multiple mechanisms including filtration of phototoxic blue light and antioxidant quenching of ..
  29. QUANTITATIVE ANALYSIS OF AGING RETINA
    Christine A Curcio; Fiscal Year: 2012
    ....
  30. SECOND MESSENGERS IN THE RETINA
    RAJU VS RAJALA; Fiscal Year: 2012
    ..In humans, age-related macular degeneration and diabetic retinopathy are the most common disorders affecting cones...
  31. CELLULAR MECHANISMS OF INHERITED RETINAL DEGENERATION
    Matthew M Lavail; Fiscal Year: 2013
    ..retinitis pigmentosa, and the most common cause of blindness in persons over the age of 60 is age-related macular degeneration. Blindness in both families of diseases is caused by photoreceptor (PR) cell death...
  32. Molecular mechanism of antiangiogenic properties of gold nanoparticle
    Priyabrata Mukherjee; Fiscal Year: 2013
    ..will have significant impact in various angiogenesis-dependent disorders such as rheumatoid arthritis, macular degeneration, diabetic retinopathy, and cancer...
  33. Development of Small Heat Shock Proteins as Therapeutic Agents in the Eye
    JONATHAN MARK PETRASH; Fiscal Year: 2010
    ..degeneration of the cells in the eye underlies various pathologies including cataracts, age related macular degeneration and glaucoma, currently there are no approved therapeutic agents for treating cellular degeneration ..
  34. Regulated Transgene Expression in the Retina
    James M Wilson; Fiscal Year: 2010
    ..AAV-encoded genes after introduction into the retina for the treatment of the wet form of age-related macular degeneration (AMD)...
  35. PROTEIN KINASE C IN THE LENS
    DOLORES JEAN TAKEMOTO; Fiscal Year: 2010
    ..Both could cause severe damage to ocular tissues such as retina (i.e., diabetic retinopathy, stroke, or macular degeneration) or lens (cataracts) and this could result in blindness...
  36. Establishing a neuroprotection model in the nonhuman primate to support translati
    MATTHEW SWAN LAWRENCE; Fiscal Year: 2013
    ..cell loss in the setting of models of retinal detachment, retinitis pigmentosa and age related macular degeneration (AMD), and retinal ganglion cells (RGCs) loss in disease models specifically impacting inner retinal and ..
  37. SYNTHESES AND CELLULAR STUDIES OF NEW PHOTOSENSITIZERS FOR MEDICAL APPLICATIONS
    Kevin M Smith; Fiscal Year: 2013
    ..photodynamic therapy (PDT) photosensitizers for use in diagnosis and treatment of cancer and age-related macular degeneration, for use against atherosclerotic lesions, in virus eradication from blood, bone marrow purging, and for ..
  38. Molecular Regulation of Vascular Regression
    Roberto Nicosia; Fiscal Year: 2013
    ..The same consideration applies to patients with wet age related macular degeneration or diabetic retinopathy...
  39. Lipid Activated Nuclear Receptors in Age-Related Macular Degeneration
    Goldis Malek; Fiscal Year: 2013
    ..epithelial (sub-RPE) deposit formation, the hallmark of the early 'dry'form of age-related macular degeneration (AMD), and the leading cause of vision loss in the elderly, are not known...
  40. Structural and Functional Changes in Myopia and Susceptibility to Glaucoma
    Lisa Ostrin; Fiscal Year: 2013
    ..Myopia is associated with retinal detachment, macular degeneration, cataract and glaucoma, with high myopia being one of the leading causes of blindness...
  41. AAV vectors for retinal delivery in a mouse model of age-related retinopathy
    KATHARINE LIANG; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Age-Related Macular Degeneration (AMD) is the leading cause of blindness in the United States, yet few therapeutics are approved to treat this disease...
  42. Role of homocysteine in retinal disease
    Sylvia B Smith; Fiscal Year: 2013
    ..g. pseudoexfoliation glaucoma), macular degeneration, and diabetic retinopathy...
  43. Novel Adeno-Associated Viral Therapy for Wet Age-Related Macular Degeneration
    James M Wilson; Fiscal Year: 2012
    ..goal of this project is to develop a novel gene-based delivery system to treat neovascular age- related macular degeneration (wet AMD), a debilitating ocular disease...
  44. COLLAGEN GENE STRUCTURE AND EXPRESSION
    Bjorn Reino Olsen; Fiscal Year: 2013
    ..XVIII leads to accumulation of protein deposits behind the retina similar to what is seen in age- dependent macular degeneration. Genetic strategies will test hypotheses of how interactions between cell surface receptors and endostatin ..
  45. Protein Kinase D2 Function and Signaling in Angiogenesis
    Hua Tang; Fiscal Year: 2012
    ..ischemic vascular diseases, atherosclerosis, tumor growth and metastasis, diabetic retinopathy, age-related macular degeneration, and rheumatoid arthritis...
  46. Quantitation of In Vivo Human Lutein Metabolism
    ANDREW JOSEPH CLIFFORD; Fiscal Year: 2010
    ..to protect the macula by acting as antioxidant and optical filters that may lower the risk of age related macular degeneration. Despite these relationships little is known about the quantitative aspects of lutein and zeaxanthin ..
  47. TRACE ELEMENT DYNAMICS IN THE VERTEBRATE EYE
    MARY C MCGAHAN; Fiscal Year: 2013
    ..in numerous ocular pathologies including cataractogenesis and retinal degenerations such as age-related macular degeneration. The study of ocular iron metabolism has been a focus of this laboratory for many years...
  48. BIOGENESIS OF MELANOSOMES
    Seth J Orlow; Fiscal Year: 2013
    ..diseases such as vitiligo, and in melanoma, and may be a modifier locus for primary congenital glaucoma and macular degeneration in X-linked retinoschisis...
  49. MEMBRANE BASIS OF VISUAL EXCITATION
    Michael F Brown; Fiscal Year: 2012
    ..Mutations of rhodopsin are implicated in macular degeneration and retinitis pigmentosa...
  50. Regulation of UV-induced apoptosis
    Heinrich Jasper; Fiscal Year: 2013
    ..important role in promoting homeostasis of the retina, influencing retinal diseases, including age-related macular degeneration. The signaling mechanisms that govern the interaction between neurons and macrophages, however, are only ..
  51. Health benefits of vigorous exercise in middle-aged versus older men and women
    Paul T Williams; Fiscal Year: 2010
    ..angina, cardiovascular disease, stroke, arthritis, gall bladder disease, vision (cataracts, glaucoma, macular degeneration), heart rhythm abnormalities, kidney stones, and cancer. Aim 2...
  52. The Role of Galectins in Corneal Hem- and Lymphangiogenesis
    Noorjahan Panjwani; Fiscal Year: 2013
    ..study extends far beyond diseases of the cornea because HA and LA dysfunctions have been found in numerous diseases including neovascular age-related macular degeneration, diabetes, cancer, AIDS and in all solid organ transplants.
  53. Mesenchymal Stem Cells for Treatment of Retinal Diseases
    Martin L Katz; Fiscal Year: 2011
    ..The results of these studies will be relevant to the treatment of diseases such as age-related macular degeneration, diabetic retinopathy, retinitis pigmentosa, and many other disorders affecting the retina and other ..
  54. Immune-mediated Neuroprotection of Retinal Ganglion Cells
    DALE SANNES GREGERSON; Fiscal Year: 2012
    ..neuroprotection in chronic diseases of the eye that have enormous health impacts on the retina (glaucoma, macular degeneration, diabetes, etc.)...
  55. Complement Factor H Haplotypes and Smoking in Age-Related Macular Degeneration
    Baerbel Rohrer; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Project Summary Age-related macular degeneration (AMD) is a slowly progressing multifactorial disease involving genetic ab- normalities and environmental insults...
  56. MATRIX MEDIATORS OF WOUND HEALING
    Paul J Higgins; Fiscal Year: 2010
    ..g., arthritis, psoriasis, cancer, cardiovascular and pulmonary fibrosis, diabetic retinopathy, macular degeneration, excessive scaring disorders)...
  57. Interphotoreceptor Matrix Based Cell Delivery Vehicle for Retinal Regeneration
    Rebecca L Carrier; Fiscal Year: 2012
    ..feasible clinical treatment for retinal degeneration associated with a wide variety of diseases, including macular degeneration and retinopathy of prematurity...
  58. Sphingolipid Metabolism and Signaling in the Retina
    Md Nawajes A Mandal; Fiscal Year: 2013
    ..area of retinal research and has relevance to many forms of human retinal dystrophies including age-related macular degeneration, diabetic retinopathy, and retinitis pigmentosa...
  59. The control of retinal vascular development by Norrin and Frizzled4
    Jeremy Nathans; Fiscal Year: 2013
    ..Age-related macular degeneration, diabetic retinopathy, and retinopathy of prematurity are all associated with the growth of new blood ..
  60. Progressive impact of diabetes on retinal neuroprotection by ?-crystallins
    Patrice E Fort; Fiscal Year: 2013
    ..retinal cell viability in chronic retinal diseases such as diabetic retinopathy, uveitis, and age-related macular degeneration. This hypothesis will be tested by pursuing three specific aims: i) determine the role of ?A- and ?B-..
  61. Immune Mechanisms in Choroidal Neovascularization
    Rajendra Apte; Fiscal Year: 2009
    ..Ocular involvement in age-related macular degeneration (AMD) often leads to significant visual impairment as a result of neovascularization in the sub-retinal ..
  62. Commercialization of iSONEP, a Humanized Monoclonal Antibody Against the Bioactiv
    ROGER ALLEN SABBADINI; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Exudative (or wet) AMD (age-related macular degeneration) is the leading cause of severe vision loss and blindness among older Americans...
  63. Pluripotent Adult Spermatogonial Stem Cells: Prospective for Retinal Degeneration
    Nady Golestaneh; Fiscal Year: 2010
    ..retina is subject to a number of degenerative conditions, including retinitis pigmentosa, age-related macular degeneration, and glaucoma...
  64. Characterization of Exudative Macular Degeneration and Diabetic Retinopathy Using
    Scott E Fraser; Fiscal Year: 2010
    ..diabetic retinopathy, retinal vein occlusions, and choroidal neovascularization associated with age-related macular degeneration (AMD))...
  65. Functional analysis of AMD-associated HTRA1 promoter polymorphism
    Noriko Esumi; Fiscal Year: 2010
    ..polymorphism that was recently identified as a variant associated with susceptibility to age-related macular degeneration (AMD), and to begin to understand the mechanism regulating HTRA1 expression...
  66. Sulfated Polysaccharide Derivatives for Treatment of Macular Degeneration
    Jianxing Zhang; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Age-related macular degeneration (AMD) is a leading cause of blindness in the U.S., affecting 8 million Americans over fifty years of age...
  67. Novel Mouse Models of Age-Related Macular Degeneration
    Jayakrishna Ambati; Fiscal Year: 2007
    Introduction: Age-related macular degeneration (AMD) is the leading cause of elderly blindness in the U.S. Absence of good animal models has limited mechanistic understanding and thwarted development of therapies...
  68. Validation and development of specific small molecule inhibitors of HTRA1 for tre
    Shuyuan Yao; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Age-related macular degeneration (AMD) is the most common cause of visual impairment of the elderly in developed countries...
  69. Mechanism of mutant TIMP-3 induced neovascularization
    Michael Tolentino; Fiscal Year: 2004
    ..and developing treatments for pathologic ocular neovascularization seen in blinding conditions such as macular degeneration and diabetic retinopathy. The training plan proposed is essential for Dr...
  70. NON-INVASIVE MEASUREMENT OF RPE LIPOFUSCIN
    Francois DeLori; Fiscal Year: 2005
    A major cause of blindness in older adults is age-related macular degeneration (AMD). Its hallmarks are neovascularization and/or atrophy of photoreceptors and retinal pigment epithelial cells (RPE)...
  71. Complement Inhibitors for Macular Degeneration
    REKHA BANSAL; Fiscal Year: 2009
    Age-related macular degeneration (AMD) affects nearly 10 million people in the U.S (Research to Prevent Blindness Foundation). Recently approved anti-VEGF therapy is the only cure for wet AMD as of today...
  72. MT1-MMP-based Animal Model of Age-related Macular Degeneration (AMD)
    George Inana; Fiscal Year: 2010
    Age-related macular degeneration (AMD) is the number one cause of blindness for the elderly population over 60. The primary damage in AMD occurs in the retinal pigment epithelium (RPE)...
  73. MASP-2 Therapy for Macular Degeneration
    CLARK TEDFORD; Fiscal Year: 2007
    ..capable of blocking human MASP-2 function as potential therapeutic agents for the treatment of age-related macular degeneration (AMD)...
  74. INDUCED APOPTOSIS IN AGE RELATED MACULAR DEGENERATION
    Thomas Ferguson; Fiscal Year: 2002
    ..Description) Neovascularization is the major cause of vision loss in patients with age- related macular degeneration (AMD), diabetic retinopathy, and retinopathy of prematurity...
  75. Identifying Cytoprotectants for Photoreceptors and RPE Cells to Treat Dry AMD
    Susan Henry; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Age-related macular degeneration (AMD) is the major cause of irreversible loss of vision in the adult population. AMD can be classified into the "dry" form and the "wet" form...
  76. Redox protein APE1/Ref-1 as a target for age-related macular degeneration (AMD)
    MARTIN HASLANGER; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Age-related macular degeneration (AMD) is the leading cause of severe vision loss in people over age 60 and an estimated 8 million older-age Americans are at high risk to develop advanced AMD...
  77. MACULAR BIOCHEMISTRY
    ALICE ADLER; Fiscal Year: 1999
    Age-related macular degeneration (AMD) is the leading cause of blindness among older Americans...