retinal neovascularization

Summary

Summary: Formation of new blood vessels originating from the retinal veins and extending along the inner (vitreal) surface of the retina.

Top Publications

  1. ncbi Diltiazem reduces retinal neovascularization in a mouse model of oxygen induced retinopathy
    R D Higgins
    Department of Pediatrics, Georgetown University Medical Center, Washington, DC 20007, USA
    Curr Eye Res 18:20-7. 1999
  2. pmc Animal models of choroidal and retinal neovascularization
    Hans E Grossniklaus
    Department of Ophthalmology, Emory University, Atlanta, GA 30322, USA
    Prog Retin Eye Res 29:500-19. 2010
  3. pmc Endogenous VEGF is required for visual function: evidence for a survival role on müller cells and photoreceptors
    Magali Saint-Geniez
    Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 3:e3554. 2008
  4. ncbi MicroRNA-126 inhibits ischemia-induced retinal neovascularization via regulating angiogenic growth factors
    Yanyan Bai
    Department of Medicine Cell Biology, Soochow University, Suzhou 215123, China
    Exp Mol Pathol 91:471-7. 2011
  5. pmc A shift in the balance of vascular endothelial growth factor and connective tissue growth factor by bevacizumab causes the angiofibrotic switch in proliferative diabetic retinopathy
    Rob J Van Geest
    Department of Ophthalmology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Br J Ophthalmol 96:587-90. 2012
  6. pmc Characterization of a mouse model of hyperglycemia and retinal neovascularization
    Elizabeth P Rakoczy
    Centre for Ophthalmology and Visual Science, The University of Western Australia, Crawley, Australia
    Am J Pathol 177:2659-70. 2010
  7. pmc Increased expression and activity of 12-lipoxygenase in oxygen-induced ischemic retinopathy and proliferative diabetic retinopathy: implications in retinal neovascularization
    Mohamed Al-Shabrawey
    Department of Oral Biology and Anatomy, Medical College of Georgia, Augusta, Georgia, USA
    Diabetes 60:614-24. 2011
  8. ncbi Development and pathology of the hyaloid, choroidal and retinal vasculature
    Magali Saint-Geniez
    Schepens Eye Research Institute, Boston, MA 02114, USA
    Int J Dev Biol 48:1045-58. 2004
  9. ncbi Pigment epithelium-derived factor: a potent inhibitor of angiogenesis
    D W Dawson
    Department of Microbiology Immunology, Department of Pathology, Robert H Lurie Comprehensive Cancer Center, Northwestern University Medical School, Chicago, IL 60611, USA
    Science 285:245-8. 1999
  10. ncbi Pigment epithelium-derived factor suppresses ischemia-induced retinal neovascularization and VEGF-induced migration and growth
    Elia J Duh
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Maumenee 809, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Invest Ophthalmol Vis Sci 43:821-9. 2002

Detail Information

Publications259 found, 100 shown here

  1. ncbi Diltiazem reduces retinal neovascularization in a mouse model of oxygen induced retinopathy
    R D Higgins
    Department of Pediatrics, Georgetown University Medical Center, Washington, DC 20007, USA
    Curr Eye Res 18:20-7. 1999
    ....
  2. pmc Animal models of choroidal and retinal neovascularization
    Hans E Grossniklaus
    Department of Ophthalmology, Emory University, Atlanta, GA 30322, USA
    Prog Retin Eye Res 29:500-19. 2010
    There have been numerous types of animal models of choroidal neovascularization (CNV) and retinal neovascularization (RNV). Understanding the pathobiology of CNV and RNV is important when evaluating and utilizing these models...
  3. pmc Endogenous VEGF is required for visual function: evidence for a survival role on müller cells and photoreceptors
    Magali Saint-Geniez
    Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 3:e3554. 2008
    ....
  4. ncbi MicroRNA-126 inhibits ischemia-induced retinal neovascularization via regulating angiogenic growth factors
    Yanyan Bai
    Department of Medicine Cell Biology, Soochow University, Suzhou 215123, China
    Exp Mol Pathol 91:471-7. 2011
    ..the potential transcriptional regulation and signal pathway of a single microRNA in ischemia-induced retinal neovascularization (NV), we used oxygen-induced retinopathy (OIR) in establishing retinal NV model, and quantitative real-..
  5. pmc A shift in the balance of vascular endothelial growth factor and connective tissue growth factor by bevacizumab causes the angiofibrotic switch in proliferative diabetic retinopathy
    Rob J Van Geest
    Department of Ophthalmology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Br J Ophthalmol 96:587-90. 2012
    ..This study investigated whether anti-VEGF agents induce accelerated fibrosis in patients with PDR, as predicted by this model...
  6. pmc Characterization of a mouse model of hyperglycemia and retinal neovascularization
    Elizabeth P Rakoczy
    Centre for Ophthalmology and Visual Science, The University of Western Australia, Crawley, Australia
    Am J Pathol 177:2659-70. 2010
    ..line not only retained the characteristics of the parental strains, such as developing hyperglycemia and retinal neovascularization, but developed higher blood glucose levels at a younger age and had worse kidney-body weight ratios than ..
  7. pmc Increased expression and activity of 12-lipoxygenase in oxygen-induced ischemic retinopathy and proliferative diabetic retinopathy: implications in retinal neovascularization
    Mohamed Al-Shabrawey
    Department of Oral Biology and Anatomy, Medical College of Georgia, Augusta, Georgia, USA
    Diabetes 60:614-24. 2011
    ..The goal of this study was to investigate whether 12-LOX plays a role in retinal neovascularization (NV).
  8. ncbi Development and pathology of the hyaloid, choroidal and retinal vasculature
    Magali Saint-Geniez
    Schepens Eye Research Institute, Boston, MA 02114, USA
    Int J Dev Biol 48:1045-58. 2004
    ..The characterization of the molecules and cell-cell interactions involved in the formation, stabilization and regression of new vessels has led to the identification of potential control points for therapeutic intervention...
  9. ncbi Pigment epithelium-derived factor: a potent inhibitor of angiogenesis
    D W Dawson
    Department of Microbiology Immunology, Department of Pathology, Robert H Lurie Comprehensive Cancer Center, Northwestern University Medical School, Chicago, IL 60611, USA
    Science 285:245-8. 1999
    ..with oxygen concentrations, suggesting that its loss plays a permissive role in ischemia-driven retinal neovascularization. These results suggest that PEDF may be of therapeutic use, especially in retinopathies where ..
  10. ncbi Pigment epithelium-derived factor suppresses ischemia-induced retinal neovascularization and VEGF-induced migration and growth
    Elia J Duh
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Maumenee 809, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Invest Ophthalmol Vis Sci 43:821-9. 2002
    To determine the effect of pigment epithelium-derived factor (PEDF) in a mouse model of ischemia-induced retinal neovascularization and on vascular endothelial growth factor (VEGF)--induced migration and growth of cultured microvascular ..
  11. ncbi Pigment epithelium-derived factor (PEDF) is an endogenous antiinflammatory factor
    Sarah X Zhang
    Department of Medicine Endocrinology, Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    FASEB J 20:323-5. 2006
    ..These findings suggest that PEDF is a novel endogenous anti-inflammatory factor in the eye. The decrease of ocular PEDF levels may contribute to inflammation and vascular leakage in DR...
  12. ncbi Rapid regression of disc and retinal neovascularization in a case of Eales disease after intravitreal bevacizumab
    Atul Kumar
    Can J Ophthalmol 42:335-6. 2007
  13. ncbi Leptin stimulates ischemia-induced retinal neovascularization: possible role of vascular endothelial growth factor expressed in retinal endothelial cells
    Eri Suganami
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Diabetes 53:2443-8. 2004
    ..This study was designed to elucidate the pathophysiologic role of leptin in the progression of retinal neovascularization. Using the retinopathy of prematurity model, a mouse model of ischemia-induced retinal ..
  14. ncbi HTRA1 promoter polymorphism in wet age-related macular degeneration
    Andrew Dewan
    Department of Epidemiology and Public Health, Yale University, 60 College Street, New Haven, CT 06520, USA
    Science 314:989-92. 2006
    ..Individuals with the risk-associated genotype were estimated to have a likelihood of developing wet AMD 10 times that of individuals with the wild-type genotype...
  15. pmc The mouse retina as an angiogenesis model
    Andreas Stahl
    Department of Ophthalmology, Harvard Medical School, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Invest Ophthalmol Vis Sci 51:2813-26. 2010
    ..From the multitude of studies performed in the mouse retina, a selection of representative works is discussed in more detail regarding their role in advancing the understanding of both the ocular and general mechanisms of angiogenesis...
  16. pmc Palomid 529, a novel small-molecule drug, is a TORC1/TORC2 inhibitor that reduces tumor growth, tumor angiogenesis, and vascular permeability
    Qi Xue
    Department of Pathology and Center for Vascular Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Res 68:9551-7. 2008
    ..However, P529 has the additional benefit of blocking pAktS473 signaling consistent with blocking TORC2 in all cells and thus bypassing feedback loops that lead to increased Akt signaling in some tumor cells...
  17. ncbi Evolution of retinal detachment in posterior retinopathy of prematurity: impact on treatment approach
    Anand Vinekar
    Associated Retinal Consultants, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    Am J Ophthalmol 145:548-555. 2008
    ..To provide insight into the course of retinal detachment in eyes with aggressive posterior retinopathy of prematurity (APROP)...
  18. ncbi Deguelin inhibits retinal neovascularization by down-regulation of HIF-1alpha in oxygen-induced retinopathy
    J H Kim
    Department of Ophthalmology, College of Medicine, Seoul National University and Seoul Artifical Eye Center Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
    J Cell Mol Med 12:2407-15. 2008
    b>Retinal neovascularization is the most common cause of blindness; Retinopathy of pre-maturity (ROP) for children and diabetic retinopathy for young age group. ROP still remains as the most serious cause of vision loss in children...
  19. ncbi Retinal endothelial angiogenic activity: effects of hypoxia and glial (Müller) cells
    Yousef Yafai
    University of Leipzig, Eye Hospital, Leipzig, Germany
    Microcirculation 11:577-86. 2004
    ..To explore the impact of retinal glial (Müller) cells on survival and neovascularization-related activities of cultured retinal endothelial cells under normoxic and hypoxic conditions...
  20. ncbi Reduced retinal angiogenesis in MMP-2-deficient mice
    Kyoko Ohno-Matsui
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113, Japan
    Invest Ophthalmol Vis Sci 44:5370-5. 2003
    To study the putative role of endogenous matrix metalloproteinases (MMPs) in retinal neovascularization, an established mouse model was used to compare the retinal neovascularization observed in wild-type mice with that in mice without ..
  21. ncbi Potential role of the angiopoietin/tie2 system in ischemia-induced retinal neovascularization
    Hitoshi Takagi
    Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawara cho, Sakyo ku, Kyoto 606 8397, Japan
    Invest Ophthalmol Vis Sci 44:393-402. 2003
    ..In the study described herein, the role of these molecules in ischemic retinal disorders was investigated...
  22. ncbi The activated form of gelatinase B/matrix metalloproteinase-9 is associated with diabetic vitreous hemorrhage
    Francis J Descamps
    Laboratory of Immunobiology, Rega Institute, University of Leuven, Belgium
    Exp Eye Res 83:401-7. 2006
    ..001) and strongly correlated with hemoglobin levels (r=0.7525; p<0.001). Activated MMP-9 was not detected in paired serum samples. We conclude that activated MMP-9 might be involved in hemorrhagic transformation in patients with PDR...
  23. ncbi Polyethylene glycol-modified pigment epithelial-derived factor: new prospects for treatment of retinal neovascularization
    Yu jing Bai
    Key Laboratory of Vision Loss and Restoration, Ministry of Education, Department of Ophthalmology, Peking University People s Hospital, Xizhimen South Street 11, Xi Cheng District, 100044 Beijing, China
    J Pharmacol Exp Ther 342:131-9. 2012
    Pathological retinal neovascularization and choroidal neovascularization are major causes of vision loss in a variety of clinical conditions, such as retinopathy of prematurity, age-related macular degeneration, and diabetic retinopathy...
  24. pmc Myeloid progenitors differentiate into microglia and promote vascular repair in a model of ischemic retinopathy
    Matthew R Ritter
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Clin Invest 116:3266-76. 2006
    ..with ischemic diseases such as retinopathy of prematurity and diabetic retinopathy are often due to retinal neovascularization. While significant progress has been made in the development of compounds useful for the treatment of ..
  25. pmc Connective tissue growth factor regulates retinal neovascularization through p53 protein-dependent transactivation of the matrix metalloproteinase (MMP)-2 gene
    Hembindu Chintala
    State University of New York Eye Institute, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
    J Biol Chem 287:40570-85. 2012
    ..The role of connective tissue growth factor (CTGF/CCN2) in pathological angiogenesis in the retina is unknown...
  26. ncbi Retinal angiomatous proliferation in age-related macular degeneration
    L A Yannuzzi
    LuEsther T Mertz Retinal Research Center of Manhattan Eye, Ear and Throat Hospital, New York, New York 10021, USA
    Retina 21:416-34. 2001
    ..This form of neovascular ARMD, termed retinal angiomatous proliferation (RAP) in this article, can be confused with CNV...
  27. pmc Mild endoplasmic reticulum stress promotes retinal neovascularization via induction of BiP/GRP78
    Shinsuke Nakamura
    Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu, Japan
    PLoS ONE 8:e60517. 2013
    ..into the intravitreal body of oxygen-induced retinopathy (OIR) model mice at postnatal day 14 (P14) and retinal neovascularization was quantified at P17...
  28. ncbi Ranibizumab in retinal angiomatous proliferation (RAP): influence of RAP stage on visual outcome
    Juan Reche-Frutos
    Ophthalmology Department, Hospital Clinico San Carlos, Madrid, Spain
    Eur J Ophthalmol 21:783-8. 2011
    ..To evaluate the influence of retinal angiomatous proliferation (RAP) stage on visual and anatomic outcome after ranibizumab (Lucentis®)...
  29. ncbi Anti-angiogenic effect of caffeic acid on retinal neovascularization
    Jeong Hun Kim
    Department of Ophthalmology, College of Medicine, Seoul National University and Seoul Artificial Eye Center Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
    Vascul Pharmacol 51:262-7. 2009
    ..we demonstrated caffeic acid (CA) has the anti-angiogenic activity to retinal endothelial cells and retinal neovascularization in a mouse model of ROP, which might be related to the suppression of ROS-induced VEGF expression...
  30. ncbi Circulating bone-marrow-derived endothelial precursor cells contribute to neovascularization in diabetic epiretinal membranes
    Ahmed M Abu El-Asrar
    Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia
    Acta Ophthalmol 89:222-8. 2011
    ..We investigated the presence of bone-marrow-derived endothelial precursor cells and the expression of the chemotactic pathway SDF-1 ⁄CXCL12)CXCR4 in PDR epiretinal membranes...
  31. ncbi Repeated intravitreal bevacizumab (Avastin(®)) treatment of persistent new vessels in proliferative diabetic retinopathy after complete panretinal photocoagulation
    Gerald Schmidinger
    Department of Ophthalmology, Medical University of Vienna, Austria
    Acta Ophthalmol 89:76-81. 2011
    ..To evaluate the effect of repeated intravitreal injections of bevacizumab (Avastin(®)) in patients with proliferative diabetic retinopathy and persistent new vessels after panretinal photocoagulation...
  32. pmc ADAM8 is a negative regulator of retinal neovascularization and of the growth of heterotopically injected tumor cells in mice
    Victor H Guaiquil
    Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, Caspary Research Building, Room 426, 535 East 70th Street, New York, NY 10021, USA
    J Mol Med (Berl) 88:497-505. 2010
    ..On the other hand, blocking ADAM8 could be detrimental in the context of rapidly growing tumors...
  33. pmc Inhibition of pathologic retinal neovascularization by alpha-defensins
    Matina Economopoulou
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Rm 4B17, 10 Center Dr, Bethesda, MD 20892, USA
    Blood 106:3831-8. 2005
    ..Systemic and local administration of alpha-defensins reduced retinal neovascularization by 45% and 60%, respectively, and this effect was comparable to the inhibitory effect of alpha5beta1-..
  34. ncbi Vascular endothelial growth factor-B and retinal vascular development in the mouse
    Melissa Reichelt
    School of Health Science, Griffith University Gold Coast, Southport, Australia
    Clin Experiment Ophthalmol 31:61-5. 2003
    ..The aim of this study was to analyse retinal vascular growth in the Vegfb-/- knockout mouse...
  35. ncbi SDF-1/CXCR4 contributes to the activation of tip cells and microglia in retinal angiogenesis
    Noriyuki Unoki
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Invest Ophthalmol Vis Sci 51:3362-71. 2010
    ..CONCLUSIONS. SDF-1/CXCR4 promotes retinal angiogenesis by both tip cell activation and the indirect angiogenic effects of microglia...
  36. ncbi Apelin is a crucial factor for hypoxia-induced retinal angiogenesis
    Atsushi Kasai
    Department of Pharmacotherapeutics, Setsunan University, Hirakata, Osaka 565 0871, Japan
    Arterioscler Thromb Vasc Biol 30:2182-7. 2010
    ..To investigate the role of endogenous apelin in pathological retinal angiogenesis...
  37. ncbi Müller cell-derived VEGF is a significant contributor to retinal neovascularization
    Yanyan Bai
    Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Pathol 219:446-54. 2009
    ..Ischaemia-induced retinal neovascularization and vascular leakage in the conditional VEGF knockout mice were analysed with fluorescein angiography, ..
  38. ncbi Leukocytes mediate retinal vascular remodeling during development and vaso-obliteration in disease
    Susumu Ishida
    Angiogenesis Retina Research Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 325 Cambridge Street, Boston, Massachusetts 02114, USA
    Nat Med 9:781-8. 2003
    ..Targeting these pathways may prove useful in the treatment of retinal ischemia, a leading cause of vision loss and blindness...
  39. ncbi Bevacizumab-augmented retinal laser photocoagulation in proliferative diabetic retinopathy: a randomized double-masked clinical trial
    A Mirshahi
    Eye Research Center, Farabi Eye Hospital, Medical Sciences University of Tehran, Tehran, Iran
    Eur J Ophthalmol 18:263-9. 2008
    ..To evaluate the additional therapeutic effect of single intravitreal bevacizumab injection on standard laser treatment in the management of proliferative diabetic retinopathy...
  40. ncbi Expression of cyclo-oxygenase-2 and downstream enzymes in diabetic fibrovascular epiretinal membranes
    A M Abu El-Asrar
    Department of Ophthalmology, King Abdulaziz University Hospital, Old Airport Road, Riyadh, Saudi Arabia
    Br J Ophthalmol 92:1534-9. 2008
    ....
  41. ncbi T2-TrpRS inhibits preretinal neovascularization and enhances physiological vascular regrowth in OIR as assessed by a new method of quantification
    Eyal Banin
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Invest Ophthalmol Vis Sci 47:2125-34. 2006
    ..The effects of T2-TrpRS on pathologic neovascularization were tested and compared with a potent VEGF antagonist using the mouse model of oxygen-induced retinopathy (OIR)...
  42. ncbi Implication of the hypoxia response element of the Vegf promoter in mouse models of retinal and choroidal neovascularization, but not retinal vascular development
    Stanley A Vinores
    Department of Ophthalmology, The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9289, USA
    J Cell Physiol 206:749-58. 2006
    b>Retinal neovascularization (NV) and macular edema, resulting from blood-retinal barrier (BRB) breakdown, are major causes of visual loss in ischemic retinopathies...
  43. pmc Suppression of retinal neovascularization by erythropoietin siRNA in a mouse model of proliferative retinopathy
    Jing Chen
    Department of Ophthalmology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Invest Ophthalmol Vis Sci 50:1329-35. 2009
    ..The authors investigated the inhibition of retinal EPO mRNA expression with RNA interference as a potential strategy to suppress retinal neovascularization and to prevent proliferative retinopathy.
  44. ncbi Pathologic features of vascular endothelial growth factor-induced retinopathy in the nonhuman primate
    Michael J Tolentino
    F M Kirby Center for Molecular Ophthalmology and Retina Service, Scheie Eye Institute University of Pennsylvania, Philadelphia, USA
    Am J Ophthalmol 133:373-85. 2002
    ..The purpose of this study was to further characterize the angiopathic changes that occur after intravitreal injections in a nonhuman primate and determine if preretinal neovascularization develops...
  45. ncbi Rosmarinic acid suppresses retinal neovascularization via cell cycle arrest with increase of p21(WAF1) expression
    Jeong Hun Kim
    Department of Ophthalmology, College of Medicine, Seoul National University and Seoul Artificial Eye Center Clinical Research Institute, Seoul National University Hospital, Seoul 110 744, Republic of Korea
    Eur J Pharmacol 615:150-4. 2009
    ..Herein, we demonstrated that rosmarinic acid has an anti-angiogenic activity to retinal neovascularization in a mouse model of retinopathy of prematurity, which is related to cell cycle arrest with increase of ..
  46. pmc Spare the rod and spoil the eye
    G B Arden
    Henry Wellcome Laboratories, Applied Vision Research Centre, Department of Optometry and Visual Science, City University, Northampton Square, London EC1V 0HB, UK
    Br J Ophthalmol 89:764-9. 2005
    ....
  47. ncbi Focal adhesion kinase overexpression induces enhanced pathological retinal angiogenesis
    Lori J Kornberg
    Department of Otolaryngology, College of Medicine, University of Florida, Gainesville, FL 32610, USA
    Invest Ophthalmol Vis Sci 45:4463-9. 2004
    ..The study was conducted to determine whether overexpression of FAK or FAK-related nonkinase (FRNK), an inhibitor of FAK, could influence human retinal endothelial cell (HREC) migration and in vivo angiogenesis...
  48. pmc Pharmacologic and genetic manipulation of MMP-2 and -9 affects retinal neovascularization in rodent models of OIR
    Joshua M Barnett
    Vanderbilt Eye Institute, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Invest Ophthalmol Vis Sci 48:907-15. 2007
    ..was investigated in a rat model of retinopathy of prematurity, to examine the roles of MMP-2 and -9 in retinal neovascularization. The susceptibilities of MMP-2(-/-) and -9(-/-) mice to preretinal neovascularization were investigated ..
  49. ncbi Novel anti-VEGF chimeric molecules delivered by AAV vectors for inhibition of retinal neovascularization
    P Pechan
    Department of Molecular Biology, Genzyme Corporation, Framingham, MA 01701, USA
    Gene Ther 16:10-6. 2009
    ..Our data suggest that AAV2-mediated intravitreal gene delivery of our novel molecules may be a safe and effective treatment for retinal neovascularization.
  50. ncbi Early vascular and neuronal changes in a VEGF transgenic mouse model of retinal neovascularization
    Pauline E van Eeden
    School of Animal Biology, The University of Western Australia, Crawley, Australia
    Invest Ophthalmol Vis Sci 47:4638-45. 2006
    ....
  51. ncbi Suppression of retinal neovascularization by shRNA targeting HIF-1alpha
    Xiao Bo Xia
    Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha, P R China
    Curr Eye Res 33:892-902. 2008
    ..whether vector-based HIF-1alpha -targeted shRNA expression system (pSUPER(siHIF-1alpha)) can inhibit HIF-1alpha and VEGF expression in vitro and suppress retinal neovascularization in the murine model of oxygen-induced retinopathy.
  52. pmc Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization
    E A Pierce
    Department of Ophthalmology, Children s Hospital, MA 02115
    Proc Natl Acad Sci U S A 92:905-9. 1995
    ..To investigate the role of vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) in retinal neovascularization, the expression of VEGF/VPF mRNA and protein were studied in a mouse model of proliferative retinopathy...
  53. ncbi Pleiotropic effects of YC-1 selectively inhibit pathological retinal neovascularization and promote physiological revascularization in a mouse model of oxygen-induced retinopathy
    M DeNiro
    Research Department, King Khaled Eye Specialist Hospital, Aruba Street, P O Box 7191, Riyadh 11462, Kingdom of Saudi Arabia
    Mol Pharmacol 77:348-67. 2010
    ..growth factor (VEGF) and inducible nitric-oxide synthase (iNOS) have been implicated in ischemia-induced retinal neovascularization. Retinal ischemia has been shown to induce VEGF and iNOS expression...
  54. ncbi Submacular haemorrhages associated with neovascular age-related macular degeneration
    David Henry William Steel
    Sunderland Eye Infirmary, Queen Alexandra Road, Sunderland SR2 9HP, UK
    Br J Ophthalmol 95:1051-7. 2011
    ..Using these techniques, outcomes better than the natural history have been achieved. This review aims to summarise what is known about SMH in nAMD and will discuss a variety of therapeutic interventions...
  55. ncbi Retinal neovascularization in choroidal melanoma without retinal ischemia
    Jan E E Keunen
    Ocular Oncology Service, Leiden University Medical Center, Leiden, The Netherlands
    Retina 22:371-4. 2002
  56. ncbi In vivo monitoring of VEGF-induced retinal damage in the Kimba mouse model of retinal neovascularization
    Ireni S Ali Rahman
    Centre for Ophthalmology and Visual Science, The University of Western Australia, Nedlands, Australia
    Curr Eye Res 36:654-62. 2011
    ..To monitor retinal and vascular changes associated with neovascularization, which were generated through photoreceptor-specific overexpression of human vascular endothelial growth factor (hVEGF), in transgenic trVEGF029 (Kimba) mice...
  57. ncbi Targeting CD9 produces stimulus-independent antiangiogenic effects predominantly in activated endothelial cells during angiogenesis: a novel antiangiogenic therapy
    Taro Kamisasanuki
    Department of Gene Therapy and Regenerative Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8544, Japan
    Biochem Biophys Res Commun 413:128-35. 2011
    ..These results shed light on the biological roles of CD9 and may lead to novel antiangiogenic therapies...
  58. ncbi Retinal neovascularization is suppressed with a matrix metalloproteinase inhibitor
    A Das
    Division of Ophthalmology, University of New Mexico School of Medicine, and Veterans Affairs Administration Medical Center, Albuquerque 87131, USA
    Arch Ophthalmol 117:498-503. 1999
    To determine the role of extracellular proteinases in ischemia-induced retinal neovascularization in an animal model and to examine the effect of proteinase inhibitors on retinal neovascularization.
  59. pmc Matrix metalloproteinases in diabetic retinopathy: potential role of MMP-9
    Renu A Kowluru
    Wayne State University, Kresge Eye Institute, Detroit, MI 48201, USA
    Expert Opin Investig Drugs 21:797-805. 2012
    ....
  60. ncbi Anti-angiogenic effect of luteolin on retinal neovascularization via blockade of reactive oxygen species production
    Sung Wook Park
    Fight against Angiogenesis Related Blindness Laboratory, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea
    Invest Ophthalmol Vis Sci 53:7718-26. 2012
    ..This study was performed to investigate the anti-angiogenic effect of luteolin against reactive oxygen species (ROS)-induced retinal neovascularization.
  61. ncbi Antiangiogenesis effects of endostatin in retinal neovascularization
    Yu jing Bai
    Key Laboratory of Vision Loss and Restoration, Ministry of Education, Department of Ophthalmology, Peking University People s Hospital, Beijing, PR China
    J Ocul Pharmacol Ther 29:619-26. 2013
    ..In this study, we investigated the efficacy and potential mechanisms of endostatin for the prevention of retinal neovascularization both in vitro and in vivo.
  62. pmc Computer-aided quantification of retinal neovascularization
    A Stahl
    Department of Ophthalmology, Harvard Medical School, Children s Hospital Boston, Boston, MA 02115, USA
    Angiogenesis 12:297-301. 2009
    ..This method greatly facilitates quantification of retinal angiogenesis while at the same time increasing lab-to-lab reproducibility of one of the most widely used in vivo models in angiogenesis research...
  63. ncbi Induction of IL-8, MCP-1, and bFGF by TNF-alpha in retinal glial cells: implications for retinal neovascularization during post-ischemic inflammation
    Shigeo Yoshida
    Department of Ophthalmology, Kyushu University Graduate School of Medicine, 3 1 1 Maidashi, 812 8582 Fukuoka, Japan
    Graefes Arch Clin Exp Ophthalmol 242:409-13. 2004
    ..that macrophages/microglia were activated during post-ischemic inflammation in a mouse model of ischemic retinal neovascularization, and that the angiogenesis induced by tumor necrosis factor-alpha (TNF-alpha) appeared to be modulated ..
  64. pmc Decursin inhibits retinal neovascularization via suppression of VEGFR-2 activation
    Jeong Hun Kim
    Fight against Angiogenesis Related Blindness FARB Laboratory, Department of Ophthalmology, College of Medicine, Seoul National University and Seoul Artificial Eye Center Clinical Research Institute, Seoul National University Hospital, Seoul 151 744, Korea
    Mol Vis 15:1868-75. 2009
    ..Retinopathy of prematurity (ROP), a vasoproliferative retinopathy, is a leading cause of blindness in children. We evaluated the inhibitory effect of decursin on retinal neovascularization.
  65. ncbi Trans-Chalcone prevents VEGF expression and retinal neovascularization in the ischemic retina
    Folami Lamoke
    Department of Ophthalmology, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912, USA
    Exp Eye Res 93:350-4. 2011
    b>Retinal neovascularization (RNV) is a critical pathological event and a major cause of blindness. Vascular inflammation and oxidative stress have been shown to play a key role in the induction and progression of RNV...
  66. ncbi The anatomy of the rat eye with oxygen-induced retinopathy
    James D Akula
    Department of Ophthalmology, Children s Hospital Boston, Boston, MA 02115, USA
    Doc Ophthalmol 120:41-50. 2010
    ..The ratio of anterior to posterior axial-lengths ranged from 0.45 in controls through 0.37 in the 75 model to 0.32 in the 50/10 model. Thus, eye growth is altered in these rat models of ROP...
  67. pmc Maintaining retinal astrocytes normalizes revascularization and prevents vascular pathology associated with oxygen-induced retinopathy
    Michael I Dorrell
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Glia 58:43-54. 2010
    ..However, relatively little is known about the role of glial cells during pathological retinal neovascularization (NV), a leading contributor to vision loss in industrialized nations...
  68. ncbi Treatment of retinal angiomatous proliferation in age-related macular degeneration: a series of 104 cases of retinal angiomatous proliferation
    Ferdinando Bottoni
    Department of Ophthalmology, San Giuseppe Hospital, Milan, Italy
    Arch Ophthalmol 123:1644-50. 2005
    ..To report the management of retinal angiomatous proliferation (RAP), a recently described intraretinal neovascular lesion occurring in age-related macular degeneration...
  69. ncbi New quantitative analysis, using high-resolution images, of oxygen-induced retinal neovascularization in mice
    Yuichi Chikaraishi
    Department of Biofunctional Molecules, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, 502 8585 Gifu, Japan
    Exp Eye Res 84:529-36. 2007
    Oxygen-induced retinopathy (OIR) has been widely studied as an animal model of retinal neovascularization diseases...
  70. pmc Human apolipoprotein(a) kringle V inhibits ischemia-induced retinal neovascularization via suppression of fibronectin-mediated angiogenesis
    Yangmi Lim
    Mogam Biotechnology Research Institute, Yongin, Kyonggi Do, Republic of Korea
    Diabetes 61:1599-608. 2012
    b>Retinal neovascularization is observed in progression of diabetic retinopathy. New vessels grow into the vitreous cavity in proliferative diabetic retinopathy, resulting in traction retinal detachment and vitreous hemorrhage...
  71. pmc Oxidative stress promotes ocular neovascularization
    Aling Dong
    Departments of Ophthalmology and Neuroscience, Johns Hopkins, University School of Medicine, Baltimore, Maryland, USA
    J Cell Physiol 219:544-52. 2009
    ..J. Cell. Physiol. 219: 544-552, 2009. (c) 2009 Wiley-Liss, Inc...
  72. ncbi How to overcome retinal neuropathy: the fight against angiogenesis-related blindness
    Dong Hyun Jo
    Department of Ophthalmology, College of Medicine, Seoul National University, Seoul, Korea
    Arch Pharm Res 33:1557-65. 2010
    ..In addition, because of the recent introduction of novel strategies, we describe pathogenesis-based treatment options to treat angiogenesis-related blindness...
  73. pmc Pathological angiogenesis is reduced by targeting pericytes via the NG2 proteoglycan
    Ugur Ozerdem
    La Jolla Institute for Molecular Medicine, Vascular Biology Division, La Jolla, California, USA
    Angiogenesis 7:269-76. 2004
    ..During ischemic retinal neovascularization, ectopic vessels protruding into the vitreous occur twice as frequently in wild type retinas as in NG2 ..
  74. ncbi Inhibition of Rho-dependent kinases ROCK I/II activates VEGF-driven retinal neovascularization and sprouting angiogenesis
    Jens Kroll
    Center for Biomedicine and Medical Technology Mannheim, Joint Research Division Vascular Biology Medical Faculty Mannheim, Univ of Heidelberg and the German Cancer Research Center, Ludolf Krehl Str 13 17, 68167 Mannheim, Germany
    Am J Physiol Heart Circ Physiol 296:H893-9. 2009
    ..Thus our data identify that the inhibition of Rho-dependent kinases ROCK I/II activates angiogenesis both, in vitro and in vivo...
  75. ncbi Kinetics of retinal vaso-obliteration and neovascularisation in the oxygen-induced retinopathy (OIR) mouse model
    C Lange
    Laboratory for Cell Biology, University Eye Hospital, 79106 Freiburg, Germany
    Graefes Arch Clin Exp Ophthalmol 247:1205-11. 2009
    ....
  76. ncbi Therapeutic interference with EphrinB2 signalling inhibits oxygen-induced angioproliferative retinopathy
    Christoph Ehlken
    University Eye Hospital, Freiburg, Germany
    Acta Ophthalmol 89:82-90. 2011
    ..To investigate whether EphrinB2 (EfnB2) or EphB4 influence retinal angiogenesis under physiological or pathological conditions...
  77. pmc Resveratrol inhibits pathologic retinal neovascularization in Vldlr(-/-) mice
    Jing Hua
    Department of Ophthalmology, Harvard Medical School, Children s Hospital, Boston, Massachusetts 02115, USA
    Invest Ophthalmol Vis Sci 52:2809-16. 2011
    ..low-density lipoprotein receptor mutant mice (Vldlr(-/-)) exhibit critical features of MacTel such as retinal neovascularization and photoreceptor degeneration...
  78. ncbi Evidence for a critical role of panretinal pathophysiology in experimental ROP
    Bruce A Berkowitz
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, 540 E Canfield, Detroit, MI 48201, USA
    Doc Ophthalmol 120:13-24. 2010
    ..of retinopathy of prematurity, which were largely focused on the temporal and spatial links between retinal neovascularization (NV), vascular oxygenation, and intraretinal ion regulation...
  79. ncbi Preoperative intravitreal bevacizumab use as an adjuvant to diabetic vitrectomy: histopathologic findings and clinical implications
    Hazem A El-Sabagh
    Magrabi Eye and Ear Center, Dammam, Saudi Arabia
    Ophthalmology 118:636-41. 2011
    ..To evaluate the effects of intervals between preoperative intravitreal injection of bevacizumab (IVB) and surgery on the components of removed diabetic fibrovascular proliferative membranes...
  80. pmc The development of the rat model of retinopathy of prematurity
    Joshua M Barnett
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA
    Doc Ophthalmol 120:3-12. 2010
    ..ROP is characterized by pathological ocular angiogenesis or retinal neovascularization (NV)...
  81. pmc Identification of genes and pathways involved in retinal neovascularization by microarray analysis of two animal models of retinal angiogenesis
    Franco M Recchia
    Retina Division, Vanderbilt Eye Institute, Nashville, Tennessee 37232, USA
    Invest Ophthalmol Vis Sci 51:1098-105. 2010
    Comparative retinal gene expression analysis in two rodent models of oxygen-induced retinopathy (OIR) was performed to identify the genes and pathways involved in retinal neovascularization.
  82. ncbi Ruboxistaurin, a PKCbeta inhibitor, inhibits retinal neovascularization via suppression of phosphorylation of ERK1/2 and Akt
    Shinsuke Nakamura
    Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, Gifu 502 8585, Japan
    Exp Eye Res 90:137-45. 2010
    ..In addition, the activation of PKC, specifically PKCbeta, plays a key role in the retinal neovascularization. However, the effect of ruboxistaurin on oxygen-induced retinopathy (OIR), an experimental murine model ..
  83. ncbi Bevacizumab pretreatment in vitrectomy with silicone oil for severe diabetic retinopathy
    Po Ting Yeh
    Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan
    Retina 29:768-74. 2009
    ..To evaluate the effects of intravitreal bevacizumab pretreatment in vitrectomy with silicone oil infusion for severe diabetic retinopathy...
  84. pmc Inhibition of NAD(P)H oxidase activity blocks vascular endothelial growth factor overexpression and neovascularization during ischemic retinopathy
    Mohamed Al-Shabrawey
    Vascular Biology Center, Medical College of Georgia, 1120 15th St, Augusta, GA 30912 2500, USA
    Am J Pathol 167:599-607. 2005
    ..in ischemic retinopathy, we evaluated the role of NAD(P)H oxidase in causing VEGF overexpression and retinal neovascularization. Dihydroethidium imaging analyses showed increased superoxide formation in areas of retinal ..
  85. ncbi Mouse model of subretinal neovascularization with choroidal anastomosis
    John R Heckenlively
    Jules Stein Eye Institute, UCLA School of Medicine, University of California at Los Angeles, 100 Stein Plaza, Los Angeles, CA 90095, USA
    Retina 23:518-22. 2003
    ..To characterize the phenotype and report a reliable genetic model of retinal angiogenesis and subretinal neovascularization in the mouse...
  86. pmc HMG-CoA reductase inhibitors (statin) prevents retinal neovascularization in a model of oxygen-induced retinopathy
    Manuela Bartoli
    Department of Ophthalmology, University of South Carolina School of Medicine, Columbia, South Carolina 29203, USA
    Invest Ophthalmol Vis Sci 50:4934-40. 2009
    b>Retinal neovascularization (RNV) is a primary cause of blindness and involves the dysfunction of retinal capillaries...
  87. ncbi Different plasma levels of vascular endothelial growth factor and nitric oxide between patients with choroidal and retinal neovascularization
    Der Chong Tsai
    Department of Ophthalmology, Taipei Veterans General Hospital and National Yang Ming University, Taipei, Taiwan, ROC
    Ophthalmologica 220:246-51. 2006
    ..explore whether choroidal neovascularization (CNV) is more influenced by plasma angiogenic factors than retinal neovascularization. The aim of this study was to investigate plasma profiles of vascular endothelial growth factor (VEGF) ..
  88. pmc TNF-alpha is critical for ischemia-induced leukostasis, but not retinal neovascularization nor VEGF-induced leakage
    Stanley A Vinores
    The Department of Ophthalmology, The Johns Hopkins University School of Medicine, Maumenee 825, 600 N Wolfe Street Baltimore, Maryland 21287 9289, United States
    J Neuroimmunol 182:73-9. 2007
    ..postulated that VEGF-induced leukostasis, breakdown of the blood-retinal barrier, and ischemia-induced retinal neovascularization may be mediated, at least in part, through TNF-alpha...
  89. ncbi Biochemical alterations in the retinas of very low-density lipoprotein receptor knockout mice: an animal model of retinal angiomatous proliferation
    Chao Li
    Department of Ophthalmology, University of Oklahoma Health Sciences Center, Dean A McGee Eye Institute, 608 Stanton L Young Blvd, Oklahoma City, OK 73104, USA
    Arch Ophthalmol 125:795-803. 2007
    ..To identify and characterize biochemical alterations in the retinas of very low-density lipoprotein receptor (VLDLr) knockout mice in an animal model of retinal angiomatous proliferation...
  90. ncbi Role of nonproteolytically activated prorenin in pathologic, but not physiologic, retinal neovascularization
    Shingo Satofuka
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 48:422-9. 2007
    ..The purpose of the present study was to investigate whether nonproteolytically activated prorenin plays a role in ischemia-induced retinal neovascularization.
  91. ncbi The significance of neuronal and glial cell changes in the rat retina during oxygen-induced retinopathy
    Erica L Fletcher
    Department of Anatomy and Cell Biology, The University of Melbourne, Grattan St, Parkville, VIC 3010, Australia
    Doc Ophthalmol 120:67-86. 2010
    ....
  92. pmc Inhibition of NAD(P)H oxidase reduces apoptosis and avascular retina in an animal model of retinopathy of prematurity
    Yuta Saito
    Department of Ophthalmology, University of North Carolina, Chapel Hill, NC 27599 7041, USA
    Mol Vis 13:840-53. 2007
    ....
  93. ncbi Calcitriol is a potent inhibitor of retinal neovascularization
    Daniel M Albert
    Departments of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53792 4673, USA
    Invest Ophthalmol Vis Sci 48:2327-34. 2007
    ..The purpose of this study was to evaluate the antiangiogenic activity of calcitriol (1,25-dihydroxyvitamin D(3)) in vivo and its effect on retinal endothelial cell (EC) proliferation, migration, and capillary morphogenesis in vitro...
  94. ncbi Histopathology of neovascular tissue from eyes with proliferative diabetic retinopathy after intravitreal bevacizumab injection
    Ri ichiro Kohno
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Am J Ophthalmol 150:223-229.e1. 2010
    ..To examine the histopathologic effect of a single intravitreal injection of bevacizumab on newly formed vessels in eyes with proliferative diabetic retinopathy (PDR)...
  95. ncbi Down-regulation of vascular endothelial growth factor and up-regulation of pigment epithelium-derived factor: a possible mechanism for the anti-angiogenic activity of plasminogen kringle 5
    Guoquan Gao
    Department of Ophthalmology, Medical University of South Carolina, Charleston, South Carolina 29403, USA
    J Biol Chem 277:9492-7. 2002
    ..injection of plasminogen kringle 5 (K5), a potent angiogenic inhibitor, inhibits ischemia-induced retinal neovascularization in a rat model...
  96. pmc IGFBP3 suppresses retinopathy through suppression of oxygen-induced vessel loss and promotion of vascular regrowth
    Chatarina Lofqvist
    Department of Ophthalmology, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:10589-94. 2007
    Vessel loss precipitates many diseases. In particular, vessel loss resulting in hypoxia induces retinal neovascularization in diabetic retinopathy and in retinopathy of prematurity (ROP), major causes of blindness...
  97. ncbi The dipeptide Arg-Gln inhibits retinal neovascularization in the mouse model of oxygen-induced retinopathy
    Josef Neu
    Departments of Pharmacology and Therapeutics, University of Florida, Gainesville 32610 0267, USA
    Invest Ophthalmol Vis Sci 47:3151-5. 2006
    ....
  98. ncbi Expression of VLDLR in the retina and evolution of subretinal neovascularization in the knockout mouse model's retinal angiomatous proliferation
    Wenzheng Hu
    Department of Ophthalmology, Indiana University School of Medicine, 702 Rotary Circle, Indianapolis, IN 46202, USA
    Invest Ophthalmol Vis Sci 49:407-15. 2008
    ..Therefore, VLDLR expression in the wild-type mouse retina was investigated and the retinal angiogenic process in vldlr(-/-) mice was characterized...
  99. ncbi Inhibition of retinal neovascularization by gene transfer of small interfering RNA targeting HIF-1alpha and VEGF
    Jian Jiang
    Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha, Hunan, China
    J Cell Physiol 218:66-74. 2009
    b>Retinal neovascularization (NV) occurs in various ocular disorders including proliferative diabetic retinopathy, retinopathy of prematurity and secondary neovascular glaucoma, which often result in blindness...
  100. ncbi Rapid resolution of severe retinal neovascularisation in proliferative diabetic retinopathy following adjunctive intravitreal bevacizumab (Avastin)
    Michael Thew
    Ophthalmology Department, Royal Brisbane and Women s Hospital, Herston, Queensland, Australia
    Clin Exp Optom 92:34-7. 2009
    ..Six days post-injection, there was almost complete resolution of new vessels...
  101. ncbi Intravitreal bevacizumab (Avastin) in proliferative diabetic retinopathy
    Angelo M Minnella
    Department of Ophthalmology, Catholic University of Sacred Hearth, Rome, Italy
    Acta Ophthalmol 86:683-7. 2008
    ..To evaluate the efficacy and safety of intravitreal bevacizumab in proliferative diabetic retinopathy (PDR) patients...

Research Grants62

  1. Novel Combretastatin A4 analogs for Treatment of Retinal Neovascularization
    Danyang Chen; Fiscal Year: 2007
    ..Abnormal angiogenesis in the retina or retinal neovascularization (NV) is one of the major pathological changes in DR...
  2. Multimodal Retinal Functional Imaging for Diabetic Retinopathy
    Hao F Zhang; Fiscal Year: 2013
    ..ischemia, and, in the final stage of DR, the growth of abnormal retinal blood vessels (pathological retinal neovascularization) known as proliferative diabetic retinopathy (PDR)...
  3. Role of lipoxygenase pathway in early microvascular dysfunction during diabetic r
    MOHAMED AL SAYED AL-SHABRAWEY; Fiscal Year: 2013
    ..upregulation of 12/15 lipoxygenase (12/15-LOX) and its lipid metabolites, 12-HETEs in DR contributes to retinal neovascularization via disrupting glial cells VEGF/PEDF balance...
  4. Dietary control of angiogenesis in retinopathy models
    Lois Smith; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The cost to society of treating retinal neovascularization (NV) is high, and the economic and human cost of not treating retinopathy is even higher. We must develop effective inexpensive interventions...
  5. The Role of the Nicotinic Cholinergic Pathway in Retinopathy of Prematurity
    John P Cooke; Fiscal Year: 2013
    ..a leading cause of vision impairment and blindness in children in the United States, due to pathological retinal neovascularization. We have discovered a novel angiogenic pathway that is involved in pathological neovascularization...
  6. Non-canonical VEGF receptor signaling regulates retinal neovascularization
    MICHAEL EDWIN BOULTON; Fiscal Year: 2012
    ..Understanding this novel non-canonical VEGF signalling pathway(s) will provide new information on angiogenesis and allow development of a sustainable treatment strategy for AMD and diabetic retinopathy. ..
  7. Fatty Acid Binding Protein and Pathological Retinal Vascularization
    Magali Saint-Geniez; Fiscal Year: 2012
    ..Based on these novel data, we hypothesize that FABP4 plays a critical role in enhancing the pathological retinal neovascularization in OIR by promoting EC activation and angiogenesis...
  8. CYP1B1 and Retinopathy of Prematurity
    Nader Sheibani; Fiscal Year: 2010
    ..We have also shown increased oxidative state mediates these effects of CYP1B1-deficiency on retinal neovascularization during OIR and can be reversed in the presence of an antioxidant...
  9. Mechanisms of retinal angiogenesis
    Gadiparthi N Rao; Fiscal Year: 2013
    ..CREB and STAT3 via enhancing the expression of DLL4 and thereby NOTCH1 signaling mediates pathological retinal neovascularization. To address this hypothesis, we will test the following three specific aims: Aim 1...
  10. Role of Nrf2 in retinal vascularization and ROP
    Elia J Duh; Fiscal Year: 2013
    ..the ischemic/hypoxic retina produces pro-angiogenic growth factors including VEGF which stimulates retinal neovascularization. Important pathophysiologic processes underlie retinal avascularity in ROP, including oxidative stress ..
  11. INTEGRINS AND OCULAR ANGIOGENESIS
    Martin Friedlander; Fiscal Year: 2013
    ..delivery systems for the delivery of combination angiostatic and neurotrophic therapies in models of retinal neovascularization. The overarching hypothesis driving this research program is that physiological angiogenesis differs ..
  12. Autologous TGF-B-Modified HSC for Repair of Vasodegenerative Diabetic Retinopathy
    STEPHEN BARTELMEZ; Fiscal Year: 2009
    ..address the primary pathology of retinal neurovascular degeneration during diabetes that precedes pre-retinal neovascularization and diabetic macular edema...
  13. Bcl-2 and ocular neovascularization
    Christine M Sorenson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Retinal neovascularization and choroidal neovascularization (CNV), as occur in retinopathy of prematurity (ROP) and age-related macular degeneration (AMD), are major causes of blindness...
  14. Regulation of diabetic retinopathy by Nrf2
    Elia J Duh; Fiscal Year: 2013
    ..edema) and capillary drop-out (which leads to retinal ischemia/hypoxia and the subsequent development of retinal neovascularization)...
  15. MicroRNAs for therapy of visual disorders
    Martin Friedlander; Fiscal Year: 2013
    ..endothelial ceils to promote angiogenesis and an anti-miR that neutralizes miR-132, thereby suppressing retinal neovascularization without affecting normal vessels...
  16. Molecular mechanisms of diabetic retinopathy
    Azza B el-Remessy; Fiscal Year: 2013
    ..glial reactivity, inflammation and acellular capillary formation that eventually lead to retinal neovascularization and blindness...
  17. Molecular Genetics of Dominant Neovascular Inflammatory Vitreoretinopathy
    Vinit B Mahajan; Fiscal Year: 2013
    ..of the ERG b-wave, progressive pigmentary retinal degeneration, peripheral field loss, and eventually retinal neovascularization, retinal detachment, and glaucoma...
  18. Potential target molecules for ischemic retinopathies
    GERARD ANTHONY LUTTY; Fiscal Year: 2011
    ..ischemic retinopathies cause significant visual loss through blood-retinal barrier (BRB) breakdown and retinal neovascularization (NV)...
  19. Neovascularization Patterns in Corneal Graft Rejection
    RONI MINTZ SHTEIN; Fiscal Year: 2011
    ..have already been shown to be safe and effective in human eyes, and are used on a routine basis for retinal neovascularization. This study will provide the basis for identifying those patients for whom such anti-angiogenic therapy ..
  20. Angiotensin II and diabetic retinopathy
    ALFONSO SCICLI; Fiscal Year: 2006
    ..Vascular Endothelial Growth Factor (VEGF) is responsible for retinal neovascularization and stimulates expression of Intercellular Adhesion Molecule-1 (ICAM-1), causing leukostasis, capillary ..
  21. A Novel BIV vector pseudotyped with thogoto virus gp75
    Tianci Luo; Fiscal Year: 2006
    ..Importantly, BlV-vector mediated delivery of an anti-angiogenic transgene efficiently blocked retinal neovascularization in a relevant rodent model, suggesting that the AVT vector is suitable for clinical applications...
  22. Therapeutic Potential of A Novel Angiogenic Inhibitor
    James Ryan; Fiscal Year: 2003
    b>Retinal neovascularization and vascular leakage are common causes leading to retinal damage in diabetic retinopathy...
  23. CAN CD 133 CELLS PREVENT HYPOXIA DRIVEN RETINAL NEOVASCULARISATION IN A RODENT MO
    Bela Anand Apte; Fiscal Year: 2007
    ..significance of ocular angiogenesis is enormous, due to the fact that in the western hemisphere, retinal neovascularization resulting from diabetic retinopathy is the most common cause of new blindness in young patients, and ..
  24. BETA 1 INTEGRIN ANTAGONISM & RETINAL NEOVASCULARIZATION
    DONALD SENGER; Fiscal Year: 2001
    ..term objective of this collaborative research plan is to identify new strategies for controlling the retinal neovascularization (NV) that leads to blindness in patients with diabetic retinopathy, age-related macular degeneration, ..
  25. Mechanism of mutant TIMP-3 induced neovascularization
    Michael Tolentino; Fiscal Year: 2004
    ..mice of adenovirus expressing mTIMP-3 will be performed to determine mTIMP-3's ability to cause sub retinal neovascularization in vivo...
  26. Treatment of Retinal Vascular Leakage Using Angiostatin
    Gennadiy Moiseyev; Fiscal Year: 2005
    ..there are two major pathological changes responsible for vision loss, diabetic macular edema (DME) and retinal neovascularization. DME can occur at early stages of diabetic retinopathy...
  27. Novel Linomide Analog for Treatment of Diabetic Retinopathy
    Kangmo Lu; Fiscal Year: 2006
    ..Diabetic macular edema (DME) and retinal neovascularization (NV) are the 2 major pathological alternations leading to the vision loss in diabetic retinopathy...
  28. Redox protein APE1/Ref-1 as a target for age-related macular degeneration (AMD)
    MARTIN HASLANGER; Fiscal Year: 2009
    ..of the proposed research is that blocking APE1/Ref-1 redox function will lead to inhibition of retinal neovascularization as a single agent efficacy, as well as enhancement of anti-VEGF treatments in AMD...
  29. Evaluation of novel BIV-based vectors in vivo
    Sheila Connelly; Fiscal Year: 2004
    ..When combined with an anti-angiogenic transgene, retinal neovascularization was effectively blocked in a transgenic mouse model of ocular disease...
  30. ADENOSINE RECEPTORS TO INHIBIT RETINAL ANGIOGENESIS
    Luiz Belardinelli; Fiscal Year: 2000
    ..Thus, blocking using adenosine receptor antagonists will inhibit retinal neovascularization by blocking the effect of adenosine...
  31. GROWTH FACTOR INDUCED TENASCIN C IN DIABETIC RETINOPATHY
    Alexander Ljubimov; Fiscal Year: 2000
    ..However, the role of basement membrane components in diabetic retinal neovascularization and the influence of growth factors on their expression remain obscure...
  32. Development of Novel BIV-based Lentiviral Vectors
    Tianci Luo; Fiscal Year: 2004
    ..Furthermore, BIV vector mediated delivery of an anti-angiogenic transgene efficiently blocked retinal neovascularization in vivo, suggesting that the vector is suitable for clinical applications...
  33. REGULATION OF RETINAL NEOVASCULARIZATION BY TIMP3
    Bela Anand Apte; Fiscal Year: 2002
    b>Retinal neovascularization is an important pathological feature of eye diseases such as diabetic retinopathy and age related macular degeneration...
  34. Novel Strategy for BIV Vector Site-Specific Integration
    Sheila Connelly; Fiscal Year: 2006
    ..Importantly, BlV-vector mediated delivery of an anti-angiogenic transgene efficiently blocked retinal neovascularization in a relevant rodent model, suggesting that the AVT vector is suitable for clinical applications...
  35. Role of ADAMs 9 and 15 in Proliferative Retinopathy
    Carl Blobel; Fiscal Year: 2009
    b>Retinal neovascularization is a major cause of blindness, and therefore improvements in our understanding of the molecular mechanism underlying this disease are needed to provide better options for treatment...
  36. Eye Mutant Resource
    Bo Chang; Fiscal Year: 2013
    ..of ocular mutants previously identified, focusing initially on eight models exhibiting sub-retinal neovascularization. The models themselves and the information gathered on each mutant will be available to the research ..
  37. MRI BIOMARKERS OF ANGIOGENESIS AND CELL INJURY IN RETINOPATHY OF PREMATURITY
    Junjie Chen; Fiscal Year: 2009
    ..therapy for proliferative retinopathy are: to develop anti-angiogenesis drug that specifically inhibit retinal neovascularization;to explore predictive markers of the diseases for preventive therapy...
  38. Developmental Retinal Neovascularization
    Lois Smith; Fiscal Year: 2007
    ..We expect this work will form the foundation of a clinical trial for IGF-1 replacement to prevent ROP and help define new therapeutic strategies to inhibit NV without compromising vessel survival. ..
  39. To Treat Some Ocular Diseases with Id1/Id3 Inhibitors
    Carol Meschter; Fiscal Year: 2004
    ..following three specific aims: (1) Examine the role of Id1/Id3 in retinal angiogenesis by quantifying retinal neovascularization in a mouse model of ischemia-induced retinal neovascularization in mice deficient in Id1 and Id3 and by ..
  40. New Thalidomide Analogs for Retinal Neovacularization
    Kangmo Lu; Fiscal Year: 2005
    ..DME) resulting from increased retinal vascular permeability and abnormal angiogenesis in the retina or retinal neovascularization (NV). Currently, there is no effective drug treatment for DME and retinal NV...
  41. CXCR4/SDF-1 Axis in Proliferation Diabetic Retinopathy
    Maria Grant; Fiscal Year: 2003
    ..of vascular endothelial growth factor (VEGF), which is currently viewed as the major effector for retinal neovascularization in diabetic retinopathy...
  42. Thrombospondin-1 and retininal vascular homeostasis
    Nader Sheibani; Fiscal Year: 2005
    ..homeostasis whose alterations under pathological conditions such as diabetes and/or ischemia results in retinal neovascularization. The studies proposed here will investigate the role of TSP1 in retinal vascular development and ..
  43. Peptide Eyedrops for Treatment of Diabetic Retinopathy
    Kangmo Lu; Fiscal Year: 2005
    ..Diabetic macular edema (DME) and retinal neovascularization are the two major pathological alternations leading to the vision loss in diabetic retinopathy...
  44. Supplemental Oxygen for Hypoxia-Related Retinal Deseases
    Quan Nguyen; Fiscal Year: 2005
    ..It is Clear that hypoxia is the driving force behind the development of retinal neovascularization (NV) in patients with ischemic retinopathies, including diabetic retinopathy and central and branch ..
  45. Antisense Morpholino Oligomers to Treat Retinopathy
    Gayathri Devi; Fiscal Year: 2003
    ..This application focuses on the inhibition of retinal neovascularization using antisense oligomers directed against endothelial cell alphav integrins, using a mouse model of ..
  46. Defining the Human Hemangioblast
    EDWARD SCOTT; Fiscal Year: 2003
    We recently developed a mouse model of retinal neovascularization that mimics many features of human disease...
  47. Drug Discovery for Diabetic Retinopathy
    ZOYA DEMIDENKO; Fiscal Year: 2007
    ..In addition, insulin and insulin-like growth factor (IGF-1) have a causative role in retinal neovascularization and diabetic retinopathy. Insulin induces HIF-1 in RPE cells, rendering such cells angiogenic...
  48. Novel Therapy for Wet Age-Related Macular Degeneration
    Sheila Connelly; Fiscal Year: 2006
    ..in Specific Aim 2 will be evaluated for efficacy following subretinal injection into a mouse model of retinal neovascularization. Inhibition of neovascularization/vascular leakage will be evaluated through several methods including ..
  49. Tissue Factor/Vlla modulation in Ocular angiogenesis
    PATRICIA PHILLIPS; Fiscal Year: 2006
    ..common cause of new-onset vision loss in young people in the USA and other industrialized countries, and retinal neovascularization is the significant contributory factor to this vision loss...
  50. Alternate Delivery of Potent Antiangiogenic Agent-AdPEDF
    Lisa Wei; Fiscal Year: 2004
    ..macular degeneration (AMD) and proliferative diabetic retinopathy (DR), due to aberrant choroidal and retinal neovascularization respectively, are two of the leading major causes of blindness in the US...
  51. kininiogen in Ocular angiogenesis-mediated disorders
    PATRICIA PHILLIPS; Fiscal Year: 2005
    ..our findings, we hypothesize that mAb C11C1 and D5 will inhibit angiogenesis in experimental models of retinal neovascularization. This novel strategy might alter the pathogenesis of retinal angiogenesis and provide an alternative ..
  52. Pharmacological Approaches to Treat Diabetic Retinopathy
    Uday Kompella; Fiscal Year: 2005
    ..animal models, VEGF-neutralizing macromolecules have been shown to reduce retinal vascular leakage and retinal neovascularization, two key pathological changes contributing to the complication of diabetic retinopathy...
  53. Adult Hemangioblast/HSC Recruitment and Maintenance
    EDWARD SCOTT; Fiscal Year: 2009
    ..Using a unique model of adult retinal neovascularization, we performed a series of experiments to ask if adult HSC exhibit hemangioblast activity by contributing ..
  54. Antiangiogenic action 16k hPRL in retinal microvessels
    Richard Weiner; Fiscal Year: 2007
    ..We hypothesize that the 16K hPRL-induced inhibition of retinal neovascularization in the OIR model is mediated by the induction of apoptosis and inhibition of MAPK signaling...
  55. TBDN-1 AS A REGULATOR OF RETINAL ANGIOGENESIS
    ROBERT GENDRON; Fiscal Year: 2001
    ..The findings of this project could indicate tbdn-1 as a potentially useful therapeutic target for treating eye diseases involving retinal neovascularization.
  56. RETINAL CAPILLARIES IN DIABETIC RETINOPATHY
    Jian Xing Ma; Fiscal Year: 2000
    ..3: Retinal neovascularization, induced by hyperoxia in KS-transgenic mice will help determine whether overexpression of KS can reduce ..
  57. Core Resources for Vision Research at MUSC
    Craig Crosson; Fiscal Year: 2007
    ..research on retinoid photochemistry, biology of phototransduction, retinal degeneration, glaucoma, retinal neovascularization, structure-function studies of the retina and retinal pigment epithelium proteins, genetics of ..
  58. The Role of SDF-1 in Hemangioblast Activity
    Jason Butler; Fiscal Year: 2006
    ..Using an animal model of adult retinal neovascularization, we performed a series of experiments that showed the adult HSC can contribute to both blood and blood ..
  59. HORMONES & NEOVASCULARIZATION IN DIABETIC RETINOPATHY
    Maria Grant; Fiscal Year: 1993
    ..I will concentrate on determining the role of insulin-like growth factor I in the development of retinal neovascularization, with emphasis on its interactions with other angiogenic agents...
  60. Protein Production of PEDF-Potent Antiangiogenic Agent
    Lisa Wei; Fiscal Year: 2003
    ..macular degeneration (AMD) and proliferative diabetic retinopathy (DR), due to aberrant choroidal and retinal neovascularization respectively, are two of the leading major causes of blindness in the US...
  61. PRECLINICAL EVALUATION OF INTERMEDIATE ENDPOINTS
    Ming You; Fiscal Year: 2000
    An experimental model of proliferative retinopathy produced in response to ischemia-induced retinal neovascularization in mice (Smith et al, 1994) lends itself as an ideal system in which to quantitate angiogenesis...
  62. STUDIES OF NORMAL AND PATHOLOGICAL RETINAL PO2
    JOHN WEITER; Fiscal Year: 1980
    ..It is hoped that long-term studies of this animal model of retinal hypoxia secondary to branch retinal vein occlusion will help elucidate the factors that contribute retinal neovascularization.