diabetic retinopathy

Summary

Summary: Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.

Top Publications

  1. ncbi Diabetic retinopathy
    Ning Cheung
    Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia
    Lancet 376:124-36. 2010
  2. pmc Global prevalence and major risk factors of diabetic retinopathy
    Joanne W Y Yau
    Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia
    Diabetes Care 35:556-64. 2012
  3. ncbi Ranibizumab for diabetic macular edema: results from 2 phase III randomized trials: RISE and RIDE
    Quan Dong Nguyen
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ophthalmology 119:789-801. 2012
  4. ncbi The RESTORE study: ranibizumab monotherapy or combined with laser versus laser monotherapy for diabetic macular edema
    Paul Mitchell
    Centre for Vision Research Westmead Millennium Institute, University of Sydney, Sydney, Australia
    Ophthalmology 118:615-25. 2011
  5. ncbi A central role for inflammation in the pathogenesis of diabetic retinopathy
    Antonia M Joussen
    Department of Vitreoretinal Surgery and Angiogenesis Laboratory, Center of Ophthalmology, University of Cologne, Koln, Germany
    FASEB J 18:1450-2. 2004
  6. ncbi Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales
    C P Wilkinson
    Greater Baltimore Medical Center, Baltimore, Maryland, USA
    Ophthalmology 110:1677-82. 2003
  7. ncbi One-year outcomes of the da Vinci Study of VEGF Trap-Eye in eyes with diabetic macular edema
    Diana V Do
    Wilmer Eye Institute, Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ophthalmology 119:1658-65. 2012
  8. pmc Inflammation in diabetic retinopathy
    Johnny Tang
    Department of Ophthalmology and Visual Sciences, University Hospitals Eye Institute, Case Western Reserve University, Cleveland, OH, USA
    Prog Retin Eye Res 30:343-58. 2011
  9. ncbi Diabetic retinopathy
    Robert N Frank
    Kresge Eye Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    N Engl J Med 350:48-58. 2004
  10. pmc The significance of vascular and neural apoptosis to the pathology of diabetic retinopathy
    Alistair J Barber
    Department of Ophthalmology, Penn State Hershey Eye Center, Penn State Hershey College of Medicine, Hershey, Pennsylvania 17033, USA
    Invest Ophthalmol Vis Sci 52:1156-63. 2011

Detail Information

Publications390 found, 100 shown here

  1. ncbi Diabetic retinopathy
    Ning Cheung
    Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia
    Lancet 376:124-36. 2010
    b>Diabetic retinopathy is a common and specific microvascular complication of diabetes, and remains the leading cause of preventable blindness in working-aged people...
  2. pmc Global prevalence and major risk factors of diabetic retinopathy
    Joanne W Y Yau
    Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia
    Diabetes Care 35:556-64. 2012
    To examine the global prevalence and major risk factors for diabetic retinopathy (DR) and vision-threatening diabetic retinopathy (VTDR) among people with diabetes.
  3. ncbi Ranibizumab for diabetic macular edema: results from 2 phase III randomized trials: RISE and RIDE
    Quan Dong Nguyen
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ophthalmology 119:789-801. 2012
    ..To evaluate the efficacy and safety of intravitreal ranibizumab in diabetic macular edema (DME) patients...
  4. ncbi The RESTORE study: ranibizumab monotherapy or combined with laser versus laser monotherapy for diabetic macular edema
    Paul Mitchell
    Centre for Vision Research Westmead Millennium Institute, University of Sydney, Sydney, Australia
    Ophthalmology 118:615-25. 2011
    ..To demonstrate superiority of ranibizumab 0.5 mg monotherapy or combined with laser over laser alone based on mean average change in best-corrected visual acuity (BCVA) over 12 months in diabetic macular edema (DME)...
  5. ncbi A central role for inflammation in the pathogenesis of diabetic retinopathy
    Antonia M Joussen
    Department of Vitreoretinal Surgery and Angiogenesis Laboratory, Center of Ophthalmology, University of Cologne, Koln, Germany
    FASEB J 18:1450-2. 2004
    b>Diabetic retinopathy is a leading cause of adult vision loss and blindness. Much of the retinal damage that characterizes the disease results from retinal vascular leakage and nonperfusion...
  6. ncbi Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales
    C P Wilkinson
    Greater Baltimore Medical Center, Baltimore, Maryland, USA
    Ophthalmology 110:1677-82. 2003
    To develop consensus regarding clinical disease severity classification systems for diabetic retinopathy and diabetic macular edema that can be used around the world, and to improve communication and coordination of care among physicians ..
  7. ncbi One-year outcomes of the da Vinci Study of VEGF Trap-Eye in eyes with diabetic macular edema
    Diana V Do
    Wilmer Eye Institute, Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ophthalmology 119:1658-65. 2012
    ..To compare different doses and dosing regimens of Vascular Endothelial Growth Factor (VEGF) Trap-Eye with laser photocoagulation in eyes with diabetic macular edema (DME)...
  8. pmc Inflammation in diabetic retinopathy
    Johnny Tang
    Department of Ophthalmology and Visual Sciences, University Hospitals Eye Institute, Case Western Reserve University, Cleveland, OH, USA
    Prog Retin Eye Res 30:343-58. 2011
    ..abnormalities in the retina, but which of these abnormalities contribute to recognized features of diabetic retinopathy (DR) is less clear...
  9. ncbi Diabetic retinopathy
    Robert N Frank
    Kresge Eye Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    N Engl J Med 350:48-58. 2004
  10. pmc The significance of vascular and neural apoptosis to the pathology of diabetic retinopathy
    Alistair J Barber
    Department of Ophthalmology, Penn State Hershey Eye Center, Penn State Hershey College of Medicine, Hershey, Pennsylvania 17033, USA
    Invest Ophthalmol Vis Sci 52:1156-63. 2011
    The most striking features of diabetic retinopathy are the vascular abnormalities that are apparent by fundus examination. There is also strong evidence that diabetes causes apoptosis of neural and vascular cells in the retina...
  11. ncbi Advances in our understanding of diabetic retinopathy
    Alan W Stitt
    Centre for Vision and Vascular Science, Queen s University of Belfast, The Royal Victoria Hospital, Belfast BT12 6BA, UK
    Clin Sci (Lond) 125:1-17. 2013
    b>Diabetic retinopathy remains the most common complication of diabetes mellitus and is a leading cause of visual loss in industrialized nations...
  12. pmc Update on animal models of diabetic retinopathy: from molecular approaches to mice and higher mammals
    Remya Robinson
    Singapore Eye Research Institute, Singapore
    Dis Model Mech 5:444-56. 2012
    b>Diabetic retinopathy (DR) is the most common microvascular complication of diabetes and one of the major causes of blindness worldwide. The pathogenesis of DR has been investigated using several animal models of diabetes...
  13. ncbi Diabetic retinopathy: seeing beyond glucose-induced microvascular disease
    David A Antonetti
    Department of Ophthalmology, Penn State College of Medicine, Hershey, PA 17033, USA
    Diabetes 55:2401-11. 2006
    b>Diabetic retinopathy remains a frightening prospect to patients and frustrates physicians. Destruction of damaged retina by photocoagulation remains the primary treatment nearly 50 years after its introduction...
  14. pmc Prevalence of diabetic retinopathy in the United States, 2005-2008
    Xinzhi Zhang
    Division of Diabetes Translation, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Hwy, NE, Atlanta, GA 30341 3727, USA
    JAMA 304:649-56. 2010
    The prevalence of diabetes in the United States has increased. People with diabetes are at risk for diabetic retinopathy. No recent national population-based estimate of the prevalence and severity of diabetic retinopathy exists.
  15. ncbi A common polymorphism in the 5'-untranslated region of the VEGF gene is associated with diabetic retinopathy in type 2 diabetes
    Takuya Awata
    Fourth Department of Internal Medicine, Saitama Medical School, Saitama, Japan
    Diabetes 51:1635-9. 2002
    ..permeability and angiogenesis, may play a pivotal role in mediating the development and progression of diabetic retinopathy. In the present study, we examined the genetic variations of the VEGF gene to assess its possible relation ..
  16. ncbi Does microvascular disease predict macrovascular events in type 2 diabetes?
    R S Rosenson
    Mount Sinai Heart, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
    Atherosclerosis 218:13-8. 2011
    ..The aim of this review was to investigate whether this association extended to the presence of any diabetic microvascular complication...
  17. ncbi Diabetic retinopathy and angiogenesis
    Talia N Crawford
    Charleston Neuroscience Institute, Retina Division, Charleston, SC 29412, USA
    Curr Diabetes Rev 5:8-13. 2009
    b>Diabetic retinopathy, a secondary microvascular complication of diabetes mellitus is the leading cause of blindness in the Unites States amongst individuals age 20 to 64...
  18. pmc Safety and efficacy of ranibizumab in diabetic macular edema (RESOLVE Study): a 12-month, randomized, controlled, double-masked, multicenter phase II study
    Pascale Massin
    Assistance Publique des Hopitaux de Paris, Ophthalmology Department, Hôpital Lariboisièe, Paris, France
    Diabetes Care 33:2399-405. 2010
    ..Ranibizumab binds to and inhibits multiple VEGF variants. We investigated the safety and efficacy of ranibizumab in DME involving the foveal center...
  19. pmc Marrow-derived cells regulate the development of early diabetic retinopathy and tactile allodynia in mice
    Guangyuan Li
    Case Western Reserve University and Case Medical Center, Cleveland, Ohio, USA
    Diabetes 61:3294-303. 2012
    ..iNOS and PARP1 are known to play a role in inflammatory processes, and we conclude that proinflammatory processes within marrow-derived cells play a central role in the development of diabetes complications in the retina and nerve...
  20. ncbi Role of intravitreal inflammatory cytokines and angiogenic factors in proliferative diabetic retinopathy
    Jinzi Zhou
    Department of Ophthalmology, Huaian No 1 People s Hospital Affiliated to Nanjing Medical University, Huaian, Jiangsu, PR China
    Curr Eye Res 37:416-20. 2012
    ..We, therefore, examined the effects of inflammatory cytokines and angiogenic factors in the pathogenesis of proliferative diabetic retinopathy (PDR) in type 2 diabetes.
  21. pmc Intravitreal ranibizumab for diabetic macular edema with prompt versus deferred laser treatment: three-year randomized trial results
    Michael J Elman
    Elman Retina Group, Baltimore, Maryland, USA
    Ophthalmology 119:2312-8. 2012
    ..5 mg ranibizumab for diabetic macular edema (DME)...
  22. ncbi High-mobility group box-1 protein activates inflammatory signaling pathway components and disrupts retinal vascular-barrier in the diabetic retina
    Ghulam Mohammad
    Department of Ophthalmology, College of Medicine, King Abdul Aziz University Hospital, King Saud University, P O Box 245, 11411 Riyadh, Saudi Arabia
    Exp Eye Res 107:101-9. 2013
    ..Our findings provide evidence that in the diabetic retina, HMGB-1 possibly interacts with RAGE and activates ERK(1/2) and NF-κB to generate an inflammatory response and disrupt retinal vascular barrier...
  23. pmc Intervention with an erythropoietin-derived peptide protects against neuroglial and vascular degeneration during diabetic retinopathy
    Carmel M McVicar
    Centre for Vision and Vascular Science, Queen s University Belfast, Belfast, Northern Ireland, UK
    Diabetes 60:2995-3005. 2011
    Erythropoietin (EPO) may be protective for early stage diabetic retinopathy, although there are concerns that it could exacerbate retinal angiogenesis and thrombosis...
  24. ncbi Expression profiles of cytokines and chemokines in vitreous fluid in diabetic retinopathy and central retinal vein occlusion
    Yukihiko Suzuki
    Department of Ophthalmology, Hirosaki University Graduate School of Medicine, 5 Zaifu, Hirosaki, Aomori, 036 8562, Japan
    Jpn J Ophthalmol 55:256-63. 2011
    ..of cytokines and chemokines in vitreous fluid is important in the development and progression of diabetic retinopathy (DR) and central retinal vein occlusion (CRVO)...
  25. pmc Preconditioning with endoplasmic reticulum stress mitigates retinal endothelial inflammation via activation of X-box binding protein 1
    Jingming Li
    Department of Medicine, Endocrinology and Diabetes, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 286:4912-21. 2011
    ....
  26. ncbi Important causes of visual impairment in the world today
    Nathan G Congdon
    Dana Center for Preventive Ophthalmology, Johns Hopkins University Schools of Medicine and Public Health, Baltimore, MD, USA
    JAMA 290:2057-60. 2003
  27. ncbi Two-year outcomes of the ranibizumab for edema of the mAcula in diabetes (READ-2) study
    Quan Dong Nguyen
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ophthalmology 117:2146-51. 2010
    ..To determine the long-term effects of ranibizumab (RBZ) in patients with diabetic macular edema (DME)...
  28. ncbi Retinopathy in diabetes
    Donald S Fong
    Diabetes Care 27:S84-7. 2004
  29. ncbi The Ins2Akita mouse as a model of early retinal complications in diabetes
    Alistair J Barber
    Penn State Retina Research Group, The Ulerich Ophthalmology Research Laboratory, Penn State College of Medicine, Hershey, 17033, USA
    Invest Ophthalmol Vis Sci 46:2210-8. 2005
    ..Male mice heterozygous for this mutation have progressive loss of beta-cell function, decreased pancreatic beta-cell density, and significant hyperglycemia, as early as 4 weeks of age...
  30. pmc Renal and retinal effects of enalapril and losartan in type 1 diabetes
    Michael Mauer
    Department of Pediatrics, University of Minnesota, Minneapolis 55455, USA
    N Engl J Med 361:40-51. 2009
    ..Nephropathy and retinopathy remain important complications of type 1 diabetes. It is unclear whether their progression is slowed by early administration of drugs that block the renin-angiotensin system...
  31. ncbi Retinal angiogenesis in development and disease
    Ray F Gariano
    Department of Ophthalmology, A 157, 300 Pasteur Drive, Stanford University School of Medicine, Palo Alto, California 94305, USA
    Nature 438:960-6. 2005
    ..angiogenesis also occurs in the retina and is a major feature of leading blinding diseases, particularly diabetic retinopathy. The retina and its clinical disorders have a pivotal role in angiogenesis research and provide model ..
  32. ncbi The prevalence of diabetic retinopathy among adults in the United States
    John H Kempen
    Department of Ophthalmology, Johns Hopkins School of Medicine, 550 N Broadway, Suite 700, Baltimore, MD 21205, USA
    Arch Ophthalmol 122:552-63. 2004
    To determine the prevalence of diabetic retinopathy among adults 40 years and older in the United States.
  33. ncbi Serum inflammatory markers in diabetic retinopathy
    Annal D Meleth
    Howard Hughes Medical Institute, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Invest Ophthalmol Vis Sci 46:4295-301. 2005
    To evaluate the association of serum factors with the severity of diabetic retinopathy and to assess their presence in retinal tissue obtained at autopsy.
  34. pmc Incidence of diabetic retinopathy in people with type 2 diabetes mellitus attending the Diabetic Retinopathy Screening Service for Wales: retrospective analysis
    R L Thomas
    Diabetes Research Unit, Centre for Endocrine and Diabetes Sciences, University Hospital of Wales, Cardiff CF14 4XW, UK
    BMJ 344:e874. 2012
    To determine the incidence of any and referable diabetic retinopathy in people with type 2 diabetes mellitus attending an annual screening service for retinopathy and whose first screening episode indicated no evidence of retinopathy.
  35. pmc Lipid peroxidation and total antioxidant capacity in vitreous, aqueous humor, and blood samples from patients with diabetic retinopathy
    Raffaele Mancino
    Ophthalmology Unit, Department of Biopathology, Tor Vergata University of Rome, Rome, Italy
    Mol Vis 17:1298-304. 2011
    ..To evaluate levels of malondialdehyde and the total antioxidant capacity (TAC) in the blood, aqueous humor, and vitreous bodies of diabetic and nondiabetic patients. We also measured the blood energy charge potential (ECP)...
  36. ncbi Diabetic retinopathy in type 1 diabetes-a contemporary analysis of 8,784 patients
    H P Hammes
    Fifth Medical Department, Medical Faculty Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Diabetologia 54:1977-84. 2011
    The aim of this study was to analyse the risk profile for diabetic retinopathy under real-life conditions in a large cohort of patients with type 1 diabetes.
  37. pmc Abrogation of MMP-9 gene protects against the development of retinopathy in diabetic mice by preventing mitochondrial damage
    Renu A Kowluru
    Kresge Eye Institute, Wayne State University, Detroit, Michigan, USA
    Diabetes 60:3023-33. 2011
    In the development of diabetic retinopathy, mitochondrial dysfunction is considered to play an important role in the apoptosis of retinal capillary cells...
  38. ncbi Fenofibrate - a potential systemic treatment for diabetic retinopathy?
    Tien Yin Wong
    Singapore Eye Research Institute, National University of Singapore, Singapore
    Am J Ophthalmol 154:6-12. 2012
    To review clinical and experimental data for fenofibrate as a possible systemic treatment for diabetic retinopathy.
  39. ncbi Angiogenic and antiangiogenic factors in proliferative diabetic retinopathy
    Rafael Simo
    Diabetes Research Unit, Endocrinology Division, Hospital Universitari Vall d Hebron, Barcelona, Spain
    Curr Diabetes Rev 2:71-98. 2006
    b>Diabetic retinopathy continues to be the leading cause of legal blindness among working-age individuals...
  40. ncbi A 2-year prospective randomized controlled trial of intravitreal bevacizumab or laser therapy (BOLT) in the management of diabetic macular edema: 24-month data: report 3
    Ranjan Rajendram
    Department of Medical Retina, Moorfields Eye Hospital, 162 City Rd, London EC1V 2PD, England, UK
    Arch Ophthalmol 130:972-9. 2012
    ..a prospective randomized controlled trial evaluating intravitreous bevacizumab and modified Early Treatment Diabetic Retinopathy Study (ETDRS) macular laser therapy (MLT) in patients with persistent clinically significant macular edema (..
  41. pmc Comparison of aqueous humor cytokine and chemokine levels in diabetic patients with and without retinopathy
    Chui Ming Gemmy Cheung
    Ocular Inflammation and Immunology Services, Singapore National Eye Centre, Singapore
    Mol Vis 18:830-7. 2012
    ..To compare the aqueous humor levels of proinflammatory and angiogenic factors of diabetic patients with and without retinopathy...
  42. ncbi Prevalence of diabetic retinopathy in various ethnic groups: a worldwide perspective
    Sobha Sivaprasad
    King s College Hospital NHS Foundation Trust, Denmark Hill, London, UK
    Surv Ophthalmol 57:347-70. 2012
    The alarming rise in diabetes prevalence is a global public health and economic problem. Diabetic retinopathy is the most common complication of diabetes and the leading cause of blindness among working-age populations in the Western ..
  43. ncbi Recent advances in understanding the biochemical and molecular mechanism of diabetic retinopathy
    Mohammad Shamsul Ola
    Department of Ophthalmology, College of Medicine, King Saud University, KAUH, Riyadh, KSA
    J Diabetes Complications 26:56-64. 2012
    One of the major complications in patients with diabetes is diabetic retinopathy (DR), a leading cause of blindness worldwide...
  44. pmc High-mobility group box-1 and biomarkers of inflammation in the vitreous from patients with proliferative diabetic retinopathy
    Ahmed M Abu El-Asrar
    Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia
    Mol Vis 17:1829-38. 2011
    ..receptor for advanced glycation end products (sRAGE) in the vitreous fluid from patients with proliferative diabetic retinopathy (PDR) and to correlate their levels with clinical disease activity and the levels of the inflammatory ..
  45. ncbi Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1. A potential mechanism for vascular permeability in diabetic retinopathy and tumors
    D A Antonetti
    Penn State Retina Research Group, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 274:23463-7. 1999
    ..may have a physiologic role in regulating vessel permeability and contributes to the pathophysiology of diabetic retinopathy as well as tumor development...
  46. pmc TNF-α signals through PKCζ/NF-κB to alter the tight junction complex and increase retinal endothelial cell permeability
    Célia A Aveleira
    Centre of Ophthalmology and Vision Sciences, Institute of Biomedical Research in Light and Image, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    Diabetes 59:2872-82. 2010
    ..In this study, the effects of IL-1β and TNF-α on retinal endothelial cell permeability were compared and the molecular mechanisms by which TNF-α increases cell permeability were elucidated...
  47. ncbi UKPDS 50: risk factors for incidence and progression of retinopathy in Type II diabetes over 6 years from diagnosis
    I M Stratton
    Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, UK
    Diabetologia 44:156-63. 2001
    AIMS/HYPOTHESIS: To determine risk factors related to the incidence and progression of diabetic retinopathy over 6 years from diagnosis of Type II (non-insulin-dependent) diabetes mellitus...
  48. ncbi Oxidative stress and diabetic retinopathy: pathophysiological mechanisms and treatment perspectives
    Sally A Madsen-Bouterse
    K 404, Kresge Eye Institute, Wayne State University, 4717 St Antoine, Detroit, MI, 48201, USA
    Rev Endocr Metab Disord 9:315-27. 2008
    ..Oxidative stress is considered as one of the crucial contributors in the pathogenesis of diabetic retinopathy, but oxidative stress appears to be highly interrelated with other biochemical imbalances that lead to ..
  49. pmc TNF-alpha mediated apoptosis plays an important role in the development of early diabetic retinopathy and long-term histopathological alterations
    Antonia M Joussen
    Department of Ophthalmology, Heinrich Heine University, Duesseldorf, Germany
    Mol Vis 15:1418-28. 2009
    The pathophysiology of diabetic retinopathy involves leukocyte adhesion to retinal vasculature, early blood-retinal barrier breakdown, capillary nonperfusion, and endothelial cell death...
  50. ncbi Vascular damage in a mouse model of diabetic retinopathy: relation to neuronal and glial changes
    Rachel A Feit-Leichman
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 46:4281-7. 2005
    Lack of information about the development of diabetic retinopathy in mice has greatly hindered the use of genetic mouse models for the study of disease mechanisms and the development of therapeutic strategies...
  51. ncbi Clinical review: The role of advanced glycation end products in progression and complications of diabetes
    Su Yen Goh
    Albert Einstein Juvenile Diabetes Research Foundation, Centre for Diabetes Complications, Diabetes and Metabolism Division, Baker Medical Research Institute, Melbourne, Victoria, Australia 8008
    J Clin Endocrinol Metab 93:1143-52. 2008
    ....
  52. pmc Vascular endothelial growth factor in eye disease
    J S Penn
    Vanderbilt University School of Medicine, Nashville, TN, USA
    Prog Retin Eye Res 27:331-71. 2008
    ..In the US, for example, retinopathy of prematurity, diabetic retinopathy and age-related macular degeneration are the principal causes of blindness in the infant, working age and ..
  53. ncbi Primary End Point (Six Months) Results of the Ranibizumab for Edema of the mAcula in diabetes (READ-2) study
    Quan Dong Nguyen
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9277, USA
    Ophthalmology 116:2175-81.e1. 2009
    ..To compare ranibizumab with focal/grid laser or a combination of both in diabetic macular edema (DME)...
  54. pmc Expression of stem cell factor/c-kit signaling pathway components in diabetic fibrovascular epiretinal membranes
    Ahmed M Abu El-Asrar
    Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia
    Mol Vis 16:1098-107. 2010
    ..components of this pathway, including c-kit, SCF, granulocyte colony-stimulating factor (G-CSF), endothelial nitric oxide synthase (eNOS), and the chemokine receptor CXCR4, in proliferative diabetic retinopathy (PDR) epiretinal membranes.
  55. pmc Quantitative assessment of early diabetic retinopathy using fractal analysis
    Ning Cheung
    Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia
    Diabetes Care 32:106-10. 2009
    ..In this study, we examined the relationship between retinal fractal dimension and retinopathy in young individuals with type 1 diabetes...
  56. ncbi Diabetic macular edema: pathogenesis and treatment
    Neelakshi Bhagat
    The Institute of Ophthalmology and Visual Science, New Jersey Medical School, Newark, New Jersey, USA
    Surv Ophthalmol 54:1-32. 2009
    ..It seems that combined pharmacologic and surgical therapy may be the best approach for the management of macular edema in diabetic patients...
  57. ncbi A prospective randomized trial of intravitreal bevacizumab or laser therapy in the management of diabetic macular edema (BOLT study) 12-month data: report 2
    Michel Michaelides
    Department of Medical Retina, Moorfields Eye Hospital, London, United Kingdom
    Ophthalmology 117:1078-1086.e2. 2010
    ..at 1 year of a study comparing repeated intravitreal bevacizumab (ivB) and modified Early Treatment of Diabetic Retinopathy Study (ETDRS) macular laser therapy (MLT) in patients with persistent clinically significant diabetic ..
  58. ncbi Expression of apoptosis markers in the retinas of human subjects with diabetes
    Ahmed M Abu-El-Asrar
    Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia
    Invest Ophthalmol Vis Sci 45:2760-6. 2004
    ..To investigate the expression of the apoptotic mediators in the retinas from human subjects with diabetes mellitus...
  59. ncbi Sustained delivery fluocinolone acetonide vitreous inserts provide benefit for at least 3 years in patients with diabetic macular edema
    Peter A Campochiaro
    Wilmer Eye Institute, Baltimore, Maryland, USA
    Ophthalmology 119:2125-32. 2012
    ..To assess long-term efficacy and safety of intravitreal inserts releasing 0.2 μg/d (low dose) or 0.5 μg/d (high dose) fluocinolone acetonide (FAc) in patients with diabetic macular edema (DME)...
  60. pmc Mitochondrial biogenesis and the development of diabetic retinopathy
    Julia M Santos
    Kresge Eye Institute, Wayne State University, Detroit, MI 48201, USA
    Free Radic Biol Med 51:1849-60. 2011
    ..parameters were confirmed in isolated retinal endothelial cells and in the retinas from human donors with diabetic retinopathy. Diabetes in WT mice increased retinal mtDNA damage and decreased copy number...
  61. pmc Epigenetic changes in mitochondrial superoxide dismutase in the retina and the development of diabetic retinopathy
    Qing Zhong
    Kresge Eye Institute, Wayne State University, Detroit, Michigan, USA
    Diabetes 60:1304-13. 2011
    ..the role of epigenetic regulation of the manganese superoxide dismutase gene (sod2) in the development of diabetic retinopathy and the metabolic memory phenomenon associated with its continued progression after hyperglycemia is ..
  62. ncbi Glial reactivity and impaired glutamate metabolism in short-term experimental diabetic retinopathy. Penn State Retina Research Group
    E Lieth
    Department of Neuroscience and Anatomy, Pennsylvania State University College of Medicine, Hershey Medical Center, 17033, USA
    Diabetes 47:815-20. 1998
    The early pathophysiology of diabetic retinopathy and the involvement of neural and vascular malfunction are poorly understood...
  63. ncbi Anti-vascular endothelial growth factor pharmacotherapy for diabetic macular edema: a report by the American Academy of Ophthalmology
    Allen C Ho
    American Academy of Ophthalmology, San Francisco, California, USA
    Ophthalmology 119:2179-88. 2012
    ..To review the evidence regarding the safety and efficacy of current anti-vascular endothelial growth factor (VEGF) pharmacotherapies for the treatment of diabetic macular edema (DME)...
  64. pmc Is diabetic retinopathy an inflammatory disease?
    A P Adamis
    Br J Ophthalmol 86:363-5. 2002
  65. ncbi Effect of antioxidant N-acetylcysteine on diabetic retinopathy and expression of VEGF and ICAM-1 from retinal blood vessels of diabetic rats
    Yuan Zhu
    Department of Ophthalmology, The First Affiliate Hospital of Xi an Jiaotong University College of Medicine, Xi an, 710061, Shaanxi, China
    Mol Biol Rep 39:3727-35. 2012
    b>Diabetic retinopathy (DR) is a leading cause of blindness globally and its pathogenesis has still not been completely elucidated. Some studies show a close relation between oxidative stress and DR...
  66. pmc Continued reduction in the prevalence of retinopathy in adolescents with type 1 diabetes: role of insulin therapy and glycemic control
    Elizabeth Downie
    Institute of Endocrinology and Diabetes, The Children s Hospital at Westmead, Sydney, New South Wales, Australia
    Diabetes Care 34:2368-73. 2011
    ..To examine trends in microvascular complications in adolescents with type 1 diabetes between 1990 and 2009 in Sydney, Australia...
  67. pmc Polymorphisms in the vascular endothelial growth factor gene and the risk of diabetic retinopathy in Chinese patients with type 2 diabetes
    Xiufen Yang
    Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China
    Mol Vis 17:3088-96. 2011
    To investigate whether single nucleotide polymorphisms (SNPs) in the vascular endothelial growth factor (VEGF) gene are associated with diabetic retinopathy (DR) in a cohort of Chinese patients with type 2 diabetes mellitus (T2DM).
  68. pmc Early neurodegeneration in the retina of type 2 diabetic patients
    Hille W van Dijk
    Department of Ophthalmology, Academic Medical Center, Amsterdam, The Netherlands
    Invest Ophthalmol Vis Sci 53:2715-9. 2012
    ..thinning of retinal layers as a sign of neurodegeneration and to investigate the possible relationship between this thinning and duration of diabetes mellitus, diabetic retinopathy (DR) status, age, sex, and glycemic control (HbA1c).
  69. pmc Expanded 2-year follow-up of ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema
    Michael J Elman
    Elman Retina Group, PA, Baltimore, Maryland, USA
    Ophthalmology 118:609-14. 2011
    ..5 mg ranibizumab or 4 mg triamcinolone combined with focal/grid laser compared with focal/grid laser alone for treatment of diabetic macular edema (DME)...
  70. pmc Müller cell-derived VEGF is essential for diabetes-induced retinal inflammation and vascular leakage
    Juanjuan Wang
    Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha, China
    Diabetes 59:2297-305. 2010
    Vascular endothelial growth factor (VEGF-A or VEGF) is a major pathogenic factor and therapeutic target for diabetic retinopathy (DR)...
  71. ncbi AGEs, RAGE, and diabetic retinopathy
    Hongliang Zong
    Centre for Vision and Vascular Science, Queen s University Belfast, Royal Victoria Hospital, Belfast, BT12 6BA, Northern Ireland, UK
    Curr Diab Rep 11:244-52. 2011
    b>Diabetic retinopathy is a major diabetic complication with a highly complex etiology...
  72. ncbi Hyperglycemia increases mitochondrial superoxide in retina and retinal cells
    Yunpeng Du
    Department of Medicine, Case Western Reserve University, Cleveland, OH 44106 4951, USA
    Free Radic Biol Med 35:1491-9. 2003
    Oxidative stress is believed to play a significant role in the development of diabetic retinopathy. In this study, we have investigated the effects of elevated glucose concentration on the production of superoxide anion by retina and ..
  73. pmc Beneficial effects of a novel RAGE inhibitor on early diabetic retinopathy and tactile allodynia
    Guangyuan Li
    Case Western Reserve University, Cleveland, OH, USA
    Mol Vis 17:3156-65. 2011
    ..We assessed the effect of a novel RAGE fusion protein inhibitor on retinal histopathology and nerve function, and on retinal inflammation and oxidative stress...
  74. ncbi MicroRNAs in early diabetic retinopathy in streptozotocin-induced diabetic rats
    Beatrix Kovacs
    Department of Ophthalmology and Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    Invest Ophthalmol Vis Sci 52:4402-9. 2011
    b>Diabetic retinopathy (DR) is one of the leading causes of blindness. However, the roles of microRNAs (miRNAs) in DR are still unknown...
  75. ncbi Matrix metalloproteinases in early diabetic retinopathy and their role in alteration of the blood-retinal barrier
    Stephen J Giebel
    Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA
    Lab Invest 85:597-607. 2005
    One of the early features of diabetic retinopathy is the alteration of the blood-retinal barrier (BRB), which may involve the breakdown of endothelial cell tight junctions...
  76. ncbi Inhibition of caspase-1/interleukin-1beta signaling prevents degeneration of retinal capillaries in diabetes and galactosemia
    Jason A Vincent
    Case Western Reserve University, Department of Medicine, Division of Clinical and Molecular Endocrinology, Center for Diabetes Research, Cleveland, OH 44106, USA
    Diabetes 56:224-30. 2007
    ..results indicate that the caspase-1/IL-1beta signaling pathway plays an important role in diabetes-induced retinal pathology, and its inhibition might represent a new strategy to inhibit capillary degeneration in diabetic retinopathy.
  77. ncbi Immunological mechanisms in the pathogenesis of diabetic retinopathy
    Anthony P Adamis
    Jerini Ophthalmic, Time and Life Building, 111 West 50th Street, 7th Floor, Gilman 7 422A, New York, NY 10020, USA
    Semin Immunopathol 30:65-84. 2008
    ..an accumulating body of evidence that immunological mechanisms play a prominent role in the pathogenesis of diabetic retinopathy (DR), which is characterized by many features typical of inflammation...
  78. pmc Single periocular injection of celecoxib-PLGA microparticles inhibits diabetes-induced elevations in retinal PGE2, VEGF, and vascular leakage
    Aniruddha C Amrite
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha 68198 5840, USA
    Invest Ophthalmol Vis Sci 47:1149-60. 2006
    ....
  79. ncbi Prevalence of diabetic retinopathy in rural China: the Handan Eye Study
    Feng Hua Wang
    Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Lab, Beijing, China
    Ophthalmology 116:461-7. 2009
    To describe the age- and gender-specific prevalence, characteristics, and severity of diabetic retinopathy (DR) in a rural population in northern China.
  80. ncbi Long-term benefit of sustained-delivery fluocinolone acetonide vitreous inserts for diabetic macular edema
    Peter A Campochiaro
    The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9277, USA
    Ophthalmology 118:626-635.e2. 2011
    ..To assess the efficacy and safety of intravitreal inserts releasing 0.2 μg/day (low dose) or 0.5 μg/day (high dose) fluocinolone acetonide (FA) in patients with diabetic macular edema (DME)...
  81. pmc A phase II randomized clinical trial of intravitreal bevacizumab for diabetic macular edema
    Ingrid U Scott
    Jaeb Center for Health Research, 15310 Amberly Drive, Suite 350, Tampa, FL 33647, USA
    Ophthalmology 114:1860-7. 2007
    ..To provide data on the short-term effect of intravitreal bevacizumab for diabetic macular edema (DME)...
  82. pmc Diabetic retinopathy in a multi-ethnic cohort in the United States
    Tien Yin Wong
    Centre for Eye Research Australia, University of Melbourne, 32 Gisborne Street, Melbourne, Victoria 3002, Australia
    Am J Ophthalmol 141:446-455. 2006
    To describe the prevalence and risk factors of diabetic retinopathy in a multi-ethnic US population of whites, blacks, hispanics, and chinese.
  83. ncbi Randomized trial of intravitreal bevacizumab alone or combined with triamcinolone versus macular photocoagulation in diabetic macular edema
    Masoud Soheilian
    Ophthalmology Department, Labbafinejad Medical Center, Shaheed Beheshti Medical University, Tehran, Iran
    Ophthalmology 116:1142-50. 2009
    ..To compare the results of intravitreal bevacizumab (IVB) injection alone or in combination with intravitreal triamcinolone acetonide (IVT) versus macular laser photocoagulation (MPC) as a primary treatment of diabetic macular edema (DME)...
  84. ncbi Proteolytic degradation of VE-cadherin alters the blood-retinal barrier in diabetes
    Deepti Navaratna
    Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA
    Diabetes 56:2380-7. 2007
    ....
  85. pmc Vitrectomy outcomes in eyes with diabetic macular edema and vitreomacular traction
    Julia A Haller
    Wills Eye Institute
    Ophthalmology 117:1087-1093.e3. 2010
    ..To evaluate vitrectomy for diabetic macular edema (DME) in eyes with at least moderate vision loss and vitreomacular traction...
  86. pmc Contributions of inflammatory processes to the development of the early stages of diabetic retinopathy
    Timothy S Kern
    Department of Medicine, Case Western Reserve University, Cleveland, OH 44106 5029, USA
    Exp Diabetes Res 2007:95103. 2007
    ..abnormalities in the retina, and these changes suggest a role for inflammation in the development of diabetic retinopathy. These changes include upregulation of iNOS, COX-2, ICAM-1, caspase 1, VEGF, and NF-kappaB, increased ..
  87. ncbi Intraocular oxygen distribution in advanced proliferative diabetic retinopathy
    Clemens A K Lange
    University College London, Institute of Ophthalmology and Moorfields Eye Hospital, National Institute for Health Research and Biomedical Research Centre, London, United Kingdom
    Am J Ophthalmol 152:406-412.e3. 2011
    To determine the preretinal distribution of oxygen in advanced proliferative diabetic retinopathy, and to investigate the relationship between intraocular oxygen tensions and vitreous cytokine concentrations.
  88. pmc Retinal microglial activation and inflammation induced by amadori-glycated albumin in a rat model of diabetes
    Ahmed S Ibrahim
    epartment of Ophthalmology, Medical College of Georgia, Augusta, Georgia, USA
    Diabetes 60:1122-33. 2011
    ..to release inflammatory cytokines that initiate neuronal loss and blood-retinal barrier breakdown seen in diabetic retinopathy (DR)...
  89. pmc Effects of p38 MAPK inhibition on early stages of diabetic retinopathy and sensory nerve function
    Yunpeng Du
    Case Western Reserve University, Cleveland, Ohio, USA
    Invest Ophthalmol Vis Sci 51:2158-64. 2010
    ..Inflammation has been linked also to the development of diabetic retinopathy in rodents...
  90. ncbi Microvascular modifications in diabetic retinopathy
    Jennifer T Durham
    Sackler School of Graduate Biomedical Sciences, Program in Cellular and Molecular Physiology, Department of Molecular Physiology and Pharmacology and the Center for Innovation in Wound Healing Research, Tufts University, 150 Harrison Avenue, Boston, MA 02111, USA
    Curr Diab Rep 11:253-64. 2011
    ..with diabetes are at elevated risks for several sight-threatening diseases, including proliferative diabetic retinopathy (DR)...
  91. pmc The retinal pigment epithelium: something more than a constituent of the blood-retinal barrier--implications for the pathogenesis of diabetic retinopathy
    Rafael Simo
    CIBER de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Instituto de Salud Carlos III ISCIII, Unitat de Diabetis i Metabolisme, Institut de Recerca Hospital Universitari Vall d Hebron, Passeig Vall d Hebron 119 129, 08035 Barcelona, Spain
    J Biomed Biotechnol 2010:190724. 2010
    ..An overview of these functions will be given. Most of the research on the physiopathology of diabetic retinopathy has been focused on the impairment of the neuroretina and the breakdown of the inner BRB...
  92. ncbi A 5-year follow-up of antioxidant supplementation in type 2 diabetic retinopathy
    Jose Javier Garcia-Medina
    Ophthalmology Research Unit Santiago Grisolia, University Hospital Doctor Peset, Valencia, Spain
    Eur J Ophthalmol 21:637-43. 2011
    This study was designed to evaluate the effect of antioxidant supplementation on diabetic retinopathy (DR) over a 5-year follow-up period. To our knowledge, this is the first such clinical trial performed.
  93. pmc Comparison of the modified Early Treatment Diabetic Retinopathy Study and mild macular grid laser photocoagulation strategies for diabetic macular edema
    Donald S Fong
    Arch Ophthalmol 125:469-80. 2007
    ..2 laser photocoagulation techniques for treatment of diabetic macular edema: the modified Early Treatment Diabetic Retinopathy Study (ETDRS) direct/grid photocoagulation technique and a potentially milder (but potentially more ..
  94. ncbi Prevalence and healthcare costs of diabetic retinopathy: a population-based register study in Sweden
    E Heintz
    Center for Medical Technology Assessment, Department of Medical and Health Sciences, Linkoping University, SE 582 83 Linköping, Sweden
    Diabetologia 53:2147-54. 2010
    The aim of the present study was to estimate the prevalence and healthcare costs of diabetic retinopathy (DR).
  95. ncbi Angiogenic growth factors and their inhibitors in diabetic retinopathy
    Anna Praidou
    2nd Department of Ophthalmology, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Curr Diabetes Rev 6:304-12. 2010
    b>Diabetic retinopathy is considered one of the vision-threatening diseases among working-age population...
  96. ncbi Macular perfusion determined by fundus fluorescein angiography at the 4-month time point in a prospective randomized trial of intravitreal bevacizumab or laser therapy in the management of diabetic macular edema (Bolt Study): Report 1
    Michel Michaelides
    Department of Medical Retina, Moorfields Eye Hospital, London, UK
    Retina 30:781-6. 2010
    ....
  97. pmc The Wisconsin Epidemiologic Study of Diabetic Retinopathy XXIII: the twenty-five-year incidence of macular edema in persons with type 1 diabetes
    Ronald Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726 2336, USA
    Ophthalmology 116:497-503. 2009
    ..To examine the 25-year cumulative incidence of macular edema (ME) and its relation to various risk factors...
  98. ncbi Sustained ocular delivery of fluocinolone acetonide by an intravitreal insert
    Peter A Campochiaro
    The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9277, USA
    Ophthalmology 117:1393-9.e3. 2010
    ..To compare Iluvien intravitreal inserts that release 0.2 or 0.5 microg/day of fluocinolone acetonide (FA) in patients with diabetic macular edema (DME)...
  99. pmc Neurodegenerative influence of oxidative stress in the retina of a murine model of diabetes
    M Sasaki
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Diabetologia 53:971-9. 2010
    b>Diabetic retinopathy is a progressive neurodegenerative disease, but the underlying mechanism is still obscure...
  100. pmc Randomized trial evaluating short-term effects of intravitreal ranibizumab or triamcinolone acetonide on macular edema after focal/grid laser for diabetic macular edema in eyes also receiving panretinal photocoagulation
    Joseph Googe
    Southeastern Retina Associates, P C, Knoxville, Tennessee, USA
    Retina 31:1009-27. 2011
    ..To evaluate 14-week effects of intravitreal ranibizumab or triamcinolone in eyes receiving focal/grid laser for diabetic macular edema and panretinal photocoagulation...
  101. ncbi Burden of illness of diabetic macular edema: literature review
    Er Chen
    Quorum Consulting Inc, San Francisco, CA 94104 3716, USA
    Curr Med Res Opin 26:1587-97. 2010
    ..To provide an overview of the literature on the burden of diabetic macular edema (DME) in the United States and selected European countries...

Research Grants77

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..such as, centralized NEI Intramural Research database, the Eye Disease Case Control Study, Early Treatment Diabetic Retinopathy Study, Framingham Eye Study, and intramural AIDS and uveitis databases...
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..such as, centralized NEI Intramural Research database, the Eye Disease Case Control Study, Early Treatment Diabetic Retinopathy Study, Framingham Eye Study, and intramural AIDS and uveitis databases...
  3. Cystathionine beta synthase (CBS) and angiogenesis
    Priyabrata Mukherjee; Fiscal Year: 2013
    ..outcome due to CBS deficiency but combat angiogenesis dependent disorders such as macular degeneration, diabetic retinopathy, etc. as well...
  4. Prolonged Inhibition of Pathologic Neovascularization by Catalytic Antioxidants
    JAMES FRANCIS MCGINNIS; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): In some forms of Diabetic Retinopathy (DR) and Macular Degeneration (AMD), blindness results from the pathologic development of new blood vessels which are incomplete, weak and porous...
  5. Role of the kallikrein-kinin system in diabetic retinopathy
    Edward P Feener; Fiscal Year: 2012
    ..XII, and high molecular weight kininogen, are present in their activated forms in vitreous from people with diabetic retinopathy. In preliminary studies, we have shown that intravitreal injection with activated purified plasma ..
  6. Cyr61/CCN1-Induced Angiogenesis and Vasculogenesis in the Retina
    Brahim Chaqour; Fiscal Year: 2010
    ..g., retinopathy of prematurity, age-related macular degeneration, diabetic retinopathy, etc)...
  7. MECHANISMS OF RETINAL VASCULAR PERMEABILITY IN DIABETES
    DAVID ANTONETTI; Fiscal Year: 2013
    b>Diabetic retinopathy remains a leading cause of blindness in the United States with no FDA approved medical therapy...
  8. Multimodal Retinal Functional Imaging for Diabetic Retinopathy
    Hao F Zhang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Diabetic retinopathy (DR) is a leading cause of irreversible blindness among working-age adults, which is a typical type of ischemia driven retinal disease characterized by microvascular damage to the ..
  9. Development of a novel method for inhibiting diabetic retinopathy
    David R Clemmons; Fiscal Year: 2012
    ..objective of the proposed study is to develop a monoclonal antibody that inhibits the progression of diabetic retinopathy. Insulin-like growth factor-I (IGF-I) has been implicated in both endothelial dysfunction as well as the ..
  10. Characterization of the thioredoxins system in the diabetic retina
    Folami Lamoke; Fiscal Year: 2013
    ..Retinal capillary loss, due to hyperglycemia-induced vascular cell death, is a prominent feature of diabetic retinopathy (DR), a common complication of diabetes and the leading cause of blindness in adults...
  11. Role of lipoxygenase pathway in early microvascular dysfunction during diabetic r
    MOHAMED AL SAYED AL-SHABRAWEY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Features of diabetic retinopathy (DR) include leukocyte/endothelial interaction (leukostasis), breakdown of blood retinal barrier (BRB) and hyperpermeability...
  12. Astrocyte Development and Reactive Gliosis
    Teri L Belecky-Adams; Fiscal Year: 2012
    ..present in many eye diseases, including glaucoma, age-related macular degeneration, retinitis pigmentosa, diabetic retinopathy and retinopathy of prematurity...
  13. Vision Sciences Training Grant
    Carol A Mason; Fiscal Year: 2013
    ..diagnostics and therapy of retinal disorders, with a focus on macular degeneration, retinitis pigmentosa, diabetic retinopathy, and retinopathy of prematurity...
  14. Gene Therapy for Retinitis Pigmentosa
    Rajendra Kumar-Singh; Fiscal Year: 2012
    ..The molecular tools developed in this study will also have application in developing therapies for diabetic retinopathy, age related macular degeneration, glaucoma etc...
  15. CYP1B1, NF-kB , and Regulation of Angiogenesis
    TAMMY LYNN PALENSKI; Fiscal Year: 2012
    ..of angiogenesis is associated with pathogenesis many diseases including retinopathy of prematurity, diabetic retinopathy and age-related macular degeneration...
  16. Role of H-Ras in Retinal Cell Death in Diabetes
    Renu A Kowluru; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Diabetic retinopathy remains the leading cause of blindness among young adults...
  17. Epidemiology of Retinopathy and other Complications in Long Term Type 1 Diabetes
    Michael Y Tsai; Fiscal Year: 2013
    ..thickness, markers of antioxidant stress, and related candidate genes and their relationships to diabetic retinopathy, diabetic nephropathy, diabetic neuropathy, myocardial infarction, stroke, and cognitive dysfunction ..
  18. SECOND MESSENGERS IN THE RETINA
    RAJU VS RAJALA; Fiscal Year: 2012
    ..In humans, age-related macular degeneration and diabetic retinopathy are the most common disorders affecting cones...
  19. PROTEIN KINASE C IN THE LENS
    DOLORES JEAN TAKEMOTO; Fiscal Year: 2010
    ..Both could cause severe damage to ocular tissues such as retina (i.e., diabetic retinopathy, stroke, or macular degeneration) or lens (cataracts) and this could result in blindness...
  20. Molecular mechanism of antiangiogenic properties of gold nanoparticle
    Priyabrata Mukherjee; Fiscal Year: 2013
    ..impact in various angiogenesis-dependent disorders such as rheumatoid arthritis, macular degeneration, diabetic retinopathy, and cancer...
  21. Integrated Multidisciplinary Strategies for Detection of Diabetic Retinopathies
    Hao F Zhang; Fiscal Year: 2010
    ..The clinical course of diabetic retinopathy is classified into stages reflecting the progression of the disease and the prognostic risk of blindness...
  22. Molecular Regulation of Vascular Regression
    Roberto Nicosia; Fiscal Year: 2013
    ..The same consideration applies to patients with wet age related macular degeneration or diabetic retinopathy. On the other hand, inducing the formation of regression-resistant blood vessels will benefit patients with ..
  23. Sphingosine 1-Phosphate: A New Target for Early Diabetic Retinopathy
    Arup Das; Fiscal Year: 2013
    ..7 million hospital bed days. Diabetic retinopathy is the leading cause of vision loss in middle-aged adults...
  24. LEUKOTRIENES AND DIABETIC RETINOPATHY
    Rose A Gubitosi-Klug; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Diabetic retinopathy is a leading cause of blindness. Prior studies implicate that, early in the disease process;chronic inflammation damages the capillaries in the retina...
  25. Role of homocysteine in retinal disease
    Sylvia B Smith; Fiscal Year: 2013
    ..g. pseudoexfoliation glaucoma), macular degeneration, and diabetic retinopathy. Mild HHcy occurs in ~5%-12% of the population;hence understanding how HHcy contributes to retinal disease ..
  26. ACCORD
    Richard Grimm; Fiscal Year: 2010
    ..nhlbi.nih.gov/health/prof/heart/other/accord/. The ACCORD Eye Study examines diabetic retinopathy with 2 eye exams of fundus photography of 7 stereoscopic fields, done in the baseline year (2003) and ..
  27. ACCORD
    Faramarz Ismail Beigi; Fiscal Year: 2010
    ..nhlbi.nih.gov/health/prof/heart/other/accord/. The ACCORD Eye Study examines diabetic retinopathy with 2 eye exams of fundus photography of 7 stereoscopic fields, done in the baseline year (2003) and ..
  28. Diabetic retinopathy: sigma receptor 1 (??R1) as a novel therapeutic target.
    Sylvia B Smith; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Diabetic retinopathy is the major sight-threatening disease in the American working-aged population. It affects retinal vasculature and neurons...
  29. Cell Communication of the Vertebrate Retina
    ROBERT FRANCIS MILLER; Fiscal Year: 2012
    ..can be additive to the ganglion cell risk factors found in conditions such as glaucoma, ischemia, injury or diabetic retinopathy. A second health-related matter of importance comes from the modern treatment of schizophrenia, where ..
  30. Partnership for Primary Care Imaging
    Stephen A Boppart; Fiscal Year: 2013
    ..prevalent diseases encountered in the primary care office, namely otitis media (middle ear infections) and diabetic retinopathy. Recent evidence has strongly associated chronic, recurrent episodes of otitis media with the presence of ..
  31. Protein Kinase D2 Function and Signaling in Angiogenesis
    Hua Tang; Fiscal Year: 2012
    ..of human diseases, including ischemic vascular diseases, atherosclerosis, tumor growth and metastasis, diabetic retinopathy, age-related macular degeneration, and rheumatoid arthritis...
  32. Mesenchymal Stem Cells for Treatment of Retinal Diseases
    Martin L Katz; Fiscal Year: 2011
    ..The results of these studies will be relevant to the treatment of diseases such as age-related macular degeneration, diabetic retinopathy, retinitis pigmentosa, and many other disorders affecting the retina and other tissues as well.
  33. Dietary control of angiogenesis in retinopathy models
    Lois Smith; Fiscal Year: 2013
    ..processed enzymatically from COX, LOX and Cyp450, mediate both vascular and neuronal homeostasis in OIR and diabetic retinopathy. Using COX1,2, LOX5,12/15 KO mice and Cyp450 endothelial specific trangenics on ?6 or ?3 PUFA diets in OIR ..
  34. Effectiveness of Immediate vs. Delayed Use of Metformin in New-Onset T2 Diabetes
    JOE VANDIVER SELBY; Fiscal Year: 2010
    ..Differences in incidence of microvascular complications (new onset diabetic retinopathy, microalbuminuria, or rate of decline in estimated glomerular filtration rate)...
  35. MATRIX MEDIATORS OF WOUND HEALING
    Paul J Higgins; Fiscal Year: 2010
    ..g., arthritis, psoriasis, cancer, cardiovascular and pulmonary fibrosis, diabetic retinopathy, macular degeneration, excessive scaring disorders)...
  36. Developing A Novel Therapy for Diabetic Retinopathy
    Danyang Chen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Diabetic retinopathy (DR) is a common complication of diabetes and a leading cause of vision loss in the United States. Unfortunately, there is no FDA-approved pharmacotherapy for DR...
  37. Progressive impact of diabetes on retinal neuroprotection by ?-crystallins
    Patrice E Fort; Fiscal Year: 2013
    ..diabetes will lead to strategies to enhance retinal cell viability in chronic retinal diseases such as diabetic retinopathy, uveitis, and age-related macular degeneration...
  38. Regulation of endogenous antioxidant systems in diabetic retinopathy
    Manuela Bartoli; Fiscal Year: 2013
    ..Aim2. Test the hypothesis that TrxR1-NY contributes to retinal OxS and progression to DR. Aim3. Test the hypothesis that HDAC6-mediated de-acetylation of Trx1 contributes to retinal OxS, inflammation and progression to DR. ..
  39. The control of retinal vascular development by Norrin and Frizzled4
    Jeremy Nathans; Fiscal Year: 2013
    ..Age-related macular degeneration, diabetic retinopathy, and retinopathy of prematurity are all associated with the growth of new blood vessels (neovascularization)..
  40. Sphingolipid Metabolism and Signaling in the Retina
    Md Nawajes A Mandal; Fiscal Year: 2013
    ..and has relevance to many forms of human retinal dystrophies including age-related macular degeneration, diabetic retinopathy, and retinitis pigmentosa...
  41. Commercialization of iSONEP, a Humanized Monoclonal Antibody Against the Bioactiv
    ROGER ALLEN SABBADINI; Fiscal Year: 2010
    ..iii) several nonclinical animal studies to assess additional applications of iSONEP beyond wet AMD, like diabetic retinopathy, dry AMD and PVR, where there are significant unmet medical needs...
  42. Immune Mechanisms in Choroidal Neovascularization
    Rajendra Apte; Fiscal Year: 2009
    ..system on these processes has broad implications for the understanding of ophthalmic diseases such as AMD, diabetic retinopathy, retinopathy of prematurity and ocular melanomas which affect diverse age groups and wherein angiogenesis ..
  43. Portable Retinal Imaging Device for Urgent Referrals and Remote Treatment
    Matthew S Muller; Fiscal Year: 2012
    ..to implement and evaluate a low cost portable retinal camera, the DLP-Cam, in a community-based system for diabetic retinopathy (DR) screening and treatment. Untreated DR has reached epidemic levels in underserved populations worldwide...
  44. Characterization of Exudative Macular Degeneration and Diabetic Retinopathy Using
    Scott E Fraser; Fiscal Year: 2010
    ..g. diabetic retinopathy, retinal vein occlusions, and choroidal neovascularization associated with age-related macular degeneration ..
  45. Easy-to-Use, Low-Cost, Handheld Retinal Camera for Screening for Diabetic Retinop
    RANDAL CHINNOCK; Fiscal Year: 2009
    ..The device is intended as a screening or diagnostic tool for diabetic retinopathy and other abnormalities of the retina...
  46. MASP-2 Antibodies for Diabetic Neuropathy
    THOMAS ANTON DUDLER; Fiscal Year: 2012
    ..diabetes is frequently associated with microvascular complications: approx 5% of diabetics develop severe diabetic retinopathy which can cause blindness, while approx 2% develop diabetic nephropathy and progress to end stage renal ..
  47. Mechanisms of Diabetic Retinopathy: Oxidative Stress and Inflammation
    Ruth B Caldwell; Fiscal Year: 2013
    ..by applicant): The long term goal of this research is to delineate the molecular mechanisms that lead to diabetic retinopathy and identify novel strategies to prevent or reverse the vascular damage...
  48. STUDY OF DIABETIC RETINOPATHY
    Timothy S Kern; Fiscal Year: 2013
    ..provides evidence that inflammatory processes contribute to the development of at least the early stages of diabetic retinopathy, and especially the degeneration of retinal capillaries...
  49. Non-canonical VEGF receptor signaling regulates retinal neovascularization
    MICHAEL EDWIN BOULTON; Fiscal Year: 2012
    Neovascular diseases of the eye include retinopathy of prematurity, proliferative diabetic retinopathy, and the exudative or "wet" form of age-related macular degeneration (AMD)...
  50. NADPH Oxidase, Mitochondrial Dysfunction and Diabetic Retinopathy
    Renu A Kowluru; Fiscal Year: 2013
    Retinopathy remains one of the most feared debilitating complications of diabetes. In the pathogenesis of diabetic retinopathy, superoxide levels are significantly elevated, mitochondria are dysfunctional and their DNA is damaged ..
  51. Role of Caveolin-1 in the Maintenance of Blood-retinal Barrier Integrity
    Michael H Elliott; Fiscal Year: 2013
    ..Loss of BRB integrity is a common pathology in three major causes of blindness: diabetic retinopathy;age- related macular degeneration;and retinopathy of prematurity...
  52. Hyperglycemia-induced translational control of gene expression in the retina
    Michael D Dennis; Fiscal Year: 2013
    Project Summary/Abstract Diabetic retinopathy is the leading cause of blindness in working age Americans, accounting for more than 12,000 new cases in the United States each year...
  53. Targeted Delivery of a Novel Synthetic Curcumin Analog, EF24 to Glioblastoma and
    MAMORU NONE SHOJI; Fiscal Year: 2012
    ..the abnormal vessels in GBM, the approach may find application in other diseases with abnormal blood vessel growth, such as diabetic retinopathy, macular degeneration, endometriosis, Crohn's disease, psoriasis, and other cancers.
  54. IL-1 beta Signaling in Diabetic Retinopathy
    Susanne Mohr; Fiscal Year: 2010
    Hyperglycemia has been found experimentally to be sufficient to initiate the development of diabetic retinopathy, but the mechanism by which hyperglycemia causes the retinal disease remains unclear...
  55. Fatty Acid Binding Protein and Pathological Retinal Vascularization
    Magali Saint-Geniez; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Retinopathy of prematurity (ROP) and diabetic retinopathy (DR) are the two leading causes of blindness in children and working-age adults, respectively...
  56. Dynamic ICG and FA Software
    Timothy Holmes; Fiscal Year: 2009
    ..for laser treatment of neovascular conditions, and the early detection of vascular changes that occur in diabetic retinopathy. Because of these many applications, there is a good potential market to make the end-product profitable...
  57. High Performance Multimodal Adaptive Optics Retinal Imaging
    R Daniel Ferguson; Fiscal Year: 2011
    ..a multimodal adaptive optics (AO) retinal imager for diagnosis of retinal diseases, including glaucoma, diabetic retinopathy (DR), age-related macular degeneration (AMD), and retinitis pigmentosa (RP)...
  58. Autologous TGF-B-Modified HSC for Repair of Vasodegenerative Diabetic Retinopathy
    STEPHEN BARTELMEZ; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Diabetic retinopathy induces retinal vascular endothelial damage resulting in ischemia, edema, and hemorrhage...
  59. VISUAL FUNCTION IN RETINAL ISCHEMIA
    Mary Johnson; Fiscal Year: 1992
    ..issue in managing patients with branch retinal vein occlusion (BVO), central retinal vein occlusion (CRVO), diabetic retinopathy or other types of ischemic retinopathy is the identification of those patients who will go on to develop ..
  60. ENDOTHELIAL CELL AUTOIMMUNITY IN DIABETIC RETINOPATHY
    Ramesh Nayak; Fiscal Year: 2001
    b>Diabetic retinopathy is a disease of the retinal microvessels that is apparently a consequence of protracted high blood glucose levels...
  61. Angiotensin II and diabetic retinopathy
    ALFONSO SCICLI; Fiscal Year: 2006
    ..Clinical trials suggest that Angiotensin Converting Enzyme inhibitors (ACEi) slow the progression of diabetic retinopathy. However, there is little experimental evidence that Angiotensin II (Ang II) is a critical pathogenetic ..
  62. DYNAMICS OF RETINOPATHY AMONG MEXICAN AMERICAN DIABETICS
    Craig Hanis; Fiscal Year: 1990
    b>Diabetic retinopathy is among the most debilitating manifestations of diabetes and is the leading cause of adult blindness in the United States...
  63. Novel Combretastatin A4 analogs for Treatment of Retinal Neovascularization
    Danyang Chen; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Diabetic retinopathy (DR) is a common complication of diabetes mellitus and a leading cause of blindness in developed countries...
  64. COST EFFECTIVENESS OF EYE RESEARCH AND CARE
    Jonathan Javitt; Fiscal Year: 1993
    ..that the implementation of treatment based upon results of clinical trials in retinopathy of prematurity, diabetic retinopathy, and glaucoma benefit not only the patient, but result in net societal savings as well...
  65. Therapeutic Potential of A Novel Angiogenic Inhibitor
    James Ryan; Fiscal Year: 2003
    Retinal neovascularization and vascular leakage are common causes leading to retinal damage in diabetic retinopathy. Currently, there is no satisfactory treatment to stop neovascularization or to reduce vascular permeability in diabetic ..
  66. Novel Antioxidants for Treatment of Diabetic Retinopathy
    Danyang Chen; Fiscal Year: 2009
    b>Diabetic retinopathy is a common complication of diabetes mellitus and a leading cause of severe vision loss and blindness around the world...
  67. Treatment of Retinal Vascular Leakage Using Angiostatin
    Gennadiy Moiseyev; Fiscal Year: 2005
    b>Diabetic retinopathy is a common complication of diabetes. It affects millions people and is a leading cause of blindness in the industrialized countries...
  68. Release of Angiogenic Inhibitors for Macular Edema
    Yan Feng; Fiscal Year: 2004
    ..Increased vascular permeability or vascular leakage in the retina is an early and common feature of diabetic retinopathy and can result in diabetic macular edema...
  69. SODIUM MRI & CSI OF EXPERIMENTAL DIABETIC RETINOPATHY
    NANCY KOLODNY; Fiscal Year: 1990
    ..chemical shift imaging (23Na CSI) to characterize the state of the vitreous body in two animal models of diabetic retinopathy. Diabetic retinopathy, a complication of diabetes, is the major cause of new blindness in persons between ..
  70. Vascular Remodeling and Effects of Angiogenic Inhibition
    Patricia Parsons Wingerter; Fiscal Year: 2006
    Pathological, excessive neovascularization is the primary cause of blindness in proliferative diabetic retinopathy (PDR)...
  71. A New Therapy for Diabetic Macular Edema
    Jian Xing Ma; Fiscal Year: 2004
    ..Vascular leakage is an early feature of diabetic retinopathy and can result in diabetic macular edema...
  72. Vacsular Remodeling and Effects of Angiogenic Inhibition in Diabetic Retinopathy
    Peter Kaiser; Fiscal Year: 2006
    Pathological, excessive neovascularization is the primary cause of blindness in proliferative diabetic retinopathy (PDR)...