- Retinal ischemia: mechanisms of damage and potential therapeutic strategies
Neville N Osborne
Nuffield Laboratory of Ophthalmology, University of Oxford, Walton Street, Oxford OX2 6AW, UK
Prog Retin Eye Res 23:91-147. 2004
..Given the increasing understanding of the events involved in ischemic neuronal injury it is hoped that clinically effective treatments for retinal ischemia will soon be available...
- The genomic response to retinal disease and injury: evidence for endothelin signaling from photoreceptors to glia
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Neurosci 25:4540-9. 2005
- Genetic and phenotypic variations of inherited retinal diseases in dogs: the power of within- and across-breed studies
Section of Ophthalmology, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, 3900 Delancey St, Philadelphia, PA 19104, USA
Mamm Genome 23:40-61. 2012
..Different forms of retinal diseases occur in specific breed(s) caused by mutations segregating within each isolated breeding population...
- Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model
Daniel M Rosenbaum
Department of Neurology, SUNY Downstate Medical Center, Brooklyn, New York, USA
J Neurosci Res 88:1569-76. 2010
..Necroptosis is programmed necrosis triggered by death receptor signaling. We investigated whether necroptosis contributes to neuronal damage and functional impairment in a model of retinal ischemia...
- Retinal microvascular abnormalities and incident stroke: the Atherosclerosis Risk in Communities Study
T Y Wong
Department of Ophthalmology, University of Wisconsin, Madison, WI 53705 2397, USA
Lancet 358:1134-40. 2001
..Retinal microvascular abnormalities reflect damage from hypertension and other vascular processes. We examined the relation of such abnormalities to incident stroke...
- Optic vesicle-like structures derived from human pluripotent stem cells facilitate a customized approach to retinal disease treatment
Jason S Meyer
Waisman Center, University of Wisconsin, Madison, Wisconsin, USA
Stem Cells 29:1206-18. 2011
..The production of OV-like populations from human pluripotent stem cells should facilitate the study of human retinal development and disease and advance the use of hiPSCs in personalized medicine...
- Distribution, markers, and functions of retinal microglia
Zhongshan Ophthalmic Center, Sun Yat Sen University of Medical Sciences, Guangzhou, P R China
Ocul Immunol Inflamm 10:27-39. 2002
..The goal of this article was to review the present knowledge about retinal microglia and the function of retinal microglia in pathological conditions...
- Perfusion abnormalities in children with cerebral malaria and malarial retinopathy
Nicholas A V Beare
St Paul s Eye Unit, Royal Liverpool University Hospital, Prescot Street, Liverpool, United Kingdom
J Infect Dis 199:263-71. 2009
..We aimed to examine retinal perfusion in children with CM by use of fluorescein angiography to investigate the pathophysiology of CM...
- Retinopathy and attenuated circadian entrainment in Crx-deficient mice
Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, USA
Nat Genet 23:466-70. 1999
..Mutations in human CRX are associated with the retinal diseases, cone-rod dystrophy-2 (adCRD2; refs 3, 4, 5), retinitis pigmentosa (RP) and Leber congenital amaurosis (LCA), ..
- State-of-the-art retinal optical coherence tomography
Biomedical Imaging Group, School of Optometry and Vision Sciences, Cardiff University, Maindy Road, CF24 4LU, Wales, United Kingdom
Prog Retin Eye Res 27:45-88. 2008
..Functional OCT promises to enable the differentiation of retinal pathologies via localized, functional retinal response or metabolic properties. These advances promise to have a powerful impact on fundamental as well as clinical studies...
- Relationship of retinal vascular caliber with diabetes and retinopathy: the Multi-Ethnic Study of Atherosclerosis (MESA)
Thanh Tan Nguyen
Centre for Eye Research Australia, University of Melbourne, 32 Gisborne Street, Victoria 3002, Australia
Diabetes Care 31:544-9. 2008
..To examine the relationship of retinal vascular caliber with diabetes, glycemia, and diabetic retinopathy...
- Protective effects of human iPS-derived retinal pigment epithelium cell transplantation in the retinal dystrophic rat
Amanda Jayne Carr
Department of Ocular Biology and Therapeutics, Institute of Ophthalmology, University College London, London, United Kingdom
PLoS ONE 4:e8152. 2009
..These findings have identified an alternative source of replacement tissue for use in human retinal cellular therapies, and provide a new in vitro cellular model system in which to study RPE diseases affecting human patients...
- Irish setter dogs affected with rod/cone dysplasia contain a nonsense mutation in the rod cGMP phosphodiesterase beta-subunit gene
M L Suber
College of Optometry, University of Houston, TX 77204
Proc Natl Acad Sci U S A 90:3968-72. 1993
- Ophthalmic drug discovery: novel targets and mechanisms for retinal diseases and glaucoma
Department of Ophthalmology and Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
Nat Rev Drug Discov 11:541-59. 2012
..This Review discusses the current state of ocular drug therapy and highlights future therapeutic opportunities...
- Relationships between age, blood pressure, and retinal vessel diameters in an older population
Department of Ophthalmology, Centre for Vision Research, and the Westmead Millennium and Save Sight Institutes, The University of Sydney, NSW, Australia
Invest Ophthalmol Vis Sci 44:2900-4. 2003
..To describe the cross-sectional relationships between age, blood pressure (BP), and quantitative measures of retinal vessel diameters in an older Australian population...
- Development and application of a next-generation-sequencing (NGS) approach to detect known and novel gene defects underlying retinal diseases
INSERM, U968, Paris, F 75012, France
Orphanet J Rare Dis 7:8. 2012
..However, these methods are time consuming, expensive and unable to provide a result if the patient carries a new gene mutation. In addition, multiplicity of phenotypes associated with the same gene defect may be overlooked...
- Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis
Kip M Connor
Department of Ophthalmology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
Nat Protoc 4:1565-73. 2009
..In this protocol we describe standards for mouse size, sample size, retinal preparation, quantification of vascular loss, vascular regrowth, NV and neovascular regression...
- Retinal microvascular abnormalities and their relationship with hypertension, cardiovascular disease, and mortality
T Y Wong
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53705 2397, USA
Surv Ophthalmol 46:59-80. 2001
..When reliably quantified, retinal microvascular abnormalities may be useful as risk indicators for cerebrovascular diseases...
- Increased dietary intake of omega-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis
Kip M Connor
Department of Ophthalmology, Harvard Medical School, Children s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
Nat Med 13:868-73. 2007
..Supplementing omega-3-PUFA intake may be of benefit in preventing retinopathy...
- Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography
Department of Medical Physics, University of Vienna, Christian Doppler Laboratory, Austria
Arch Ophthalmol 121:695-706. 2003
- Retinal vessel diameter and cardiovascular mortality: pooled data analysis from two older populations
Jie Jin Wang
Centre for Vision Research, Department of Ophthalmology, Westmead Hospital, and the Westmead Millennium Institute, University of Sydney, Australia
Eur Heart J 28:1984-92. 2007
..The retinal microvasculature may reflect pre-clinical changes in the cerebral and coronary microcirculations. We assessed whether smaller retinal arterioles and larger venules predicted coronary heart disease (CHD)- and stroke-mortality...
- Retinal vascular caliber: systemic, environmental, and genetic associations
Centre for Eye Research Australia, University of Melbourne, Victoria, Australia
Surv Ophthalmol 54:74-95. 2009
- Modulation of pro-survival and death-associated pathways under retinal ischemia/reperfusion: effects of NMDA receptor blockade
Department of Pharmacobiology, Section of Neuropharmacology of Normal and Pathological Neuronal Plasticity, University of Calabria, Arcavacata di Rende, Italy
J Neurochem 107:1347-57. 2008
..In addition, these data implicate the pro-survival PI3K/Akt pathway and the observed reduced expression of Bad in the neuroprotection afforded by MK801...
- Retinal toxicity associated with hydroxychloroquine and chloroquine: risk factors, screening, and progression despite cessation of therapy
Oregon Retinal Degeneration Center, Casey Eye Institute, Oregon Health and Science University, Portland, OR 97239 4197, USA
Arch Ophthalmol 129:30-9. 2011
..To report the detailed clinical findings of patients with retinal toxicity that developed secondary to the use of hydroxychloroquine sulfate (n = 13), chloroquine phosphate (n = 2), or a combination of the agents (n = 1)...
- Myeloid progenitors differentiate into microglia and promote vascular repair in a model of ischemic retinopathy
Matthew R Ritter
Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
J Clin Invest 116:3266-76. 2006
..These findings suggest what we believe to be a novel therapeutic approach for the treatment of ischemic retinopathies that promotes vascular repair rather than destruction...
- Retinal microvascular abnormalities and 10-year cardiovascular mortality: a population-based case-control study
Tien Yin Wong
Singapore National Eye Center and National University of Singapore, Singapore, Republic of Singapore
Ophthalmology 110:933-40. 2003
..Retinal microvascular abnormalities reflect persistent arteriolar damage from hypertension and independently predict stroke. We examined their associations with long-term cardiovascular mortality...
- Neuroprotection against retinal ischemia-reperfusion injury by blocking the angiotensin II type 1 receptor
Departments of Ophthalmology, Kagawa University Faculty of Medicine, Kagawa, Japan
Invest Ophthalmol Vis Sci 51:3629-38. 2010
..Both the ACE inhibitor and the AT1-R antagonist that were examined can block the stimulation of the AT1-R and attenuate the subsequent ischemic damage in the rat retina...
- Identification of malaria retinopathy improves the specificity of the clinical diagnosis of cerebral malaria: findings from a prospective cohort study
Gretchen L Birbeck
International Neurologic and Psychiatric Epidemiology Program, Michigan State University, East Lansing, Michigan, USA
Am J Trop Med Hyg 82:231-4. 2010
..This subset of patients may represent children with a pre-existing propensity to adverse neurologic symptoms and outcomes...
- Autoantibodies in melanoma-associated retinopathy target TRPM1 cation channels of retinal ON bipolar cells
Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Neurosci 31:3962-7. 2011
..We conclude that the vision of at least some patients with MAR is compromised due to autoantibody-mediated inactivation of the TRPM1 channel...
- Polypoidal choroidal vasculopathy with choroidal vascular hyperpermeability
Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
Am J Ophthalmol 142:601-7. 2006
..To describe the incidence and clinical characteristics of polypoidal choroidal vasculopathy (PCV) associated with choroidal vascular hyperpermeability...
- Ligation of the pterygopalatine and external carotid arteries induces ischemic damage in the murine retina
Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu, Japan
Invest Ophthalmol Vis Sci 52:9710-20. 2011
..This study aimed to characterize the functional and morphologic changes in a murine model of ocular ischemic disease caused by vascular occlusion...
- Pluripotent human stem cells for the treatment of retinal disease
Teisha J Rowland
Center for Stem Cell Biology and Engineering, University of California, Santa Barbara, California, USA
J Cell Physiol 227:457-66. 2012
Despite advancements made in our understanding of ocular biology, therapeutic options for many debilitating retinal diseases remain limited...
- Risk prediction of coronary heart disease based on retinal vascular caliber (from the Atherosclerosis Risk In Communities [ARIC] Study)
School of Public Health, University of Sydney, Sydney, Australia
Am J Cardiol 102:58-63. 2008
..In conclusion, although retinal vascular caliber independently predicted CHD risk in women, the incremental predictive ability over that of the Framingham model was modest and unlikely to translate meaningfully into clinical practice...
- In vivo confocal imaging of the retina in animal models using scanning laser ophthalmoscopy
Mathias W Seeliger
Retinal Diagnostics Research Group, Tuebingen, Germany
Vision Res 45:3512-9. 2005
..Important fields of application are studies in retinal degenerations and the follow-up of therapeutic intervention...
- Pathophysiology of stroke and stroke-induced retinal ischemia: emerging role of stem cells
Department of Neurology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
J Cell Physiol 227:1269-79. 2012
..In this review, we highlight the advantages and limitations of this approach with a focus on key observations from preclinical animal studies and clinical trials. Further research, especially on treatment with EPCs is warranted...
- High-definition and 3-dimensional imaging of macular pathologies with high-speed ultrahigh-resolution optical coherence tomography
Vivek J Srinivasan
Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Ophthalmology 113:2054.e1-14. 2006
..To assess high-speed ultrahigh-resolution optical coherence tomography (OCT) image resolution, acquisition speed, image quality, and retinal coverage for the visualization of macular pathologies...
- Retinopathy and risk of congestive heart failure
Tien Y Wong
Centre for Eye Research Australia, University of Melbourne, Victoria, Australia
JAMA 293:63-9. 2005
..The pathogenesis of CHF is uncertain, but microvascular disease has been hypothesized as a possible factor...
- Using multifocal ERG ring ratios to detect and follow Plaquenil retinal toxicity: a review : Review of mfERG ring ratios in Plaquenil toxicity
Jonathan S Lyons
Georgetown University Washington National Eye Center, Washington, DC, USA
Doc Ophthalmol 118:29-36. 2009
..It appears appropriate to recommend that mfERG testing be done on all patients on Plaquenil therapy...
- Inhibition of reactive gliosis prevents neovascular growth in the mouse model of oxygen-induced retinopathy
Research Department, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
PLoS ONE 6:e22244. 2011
..In addition, the study reveals that YC-1 may exert promising therapeutic effects in the treatment of retinal and neuronal pathologies...
- Neuroprotective effects of angiotensin II type 1 receptor (AT1-R) blocker via modulating AT1-R signaling and decreased extracellular glutamate levels
Department of Ophthalmology, Kagawa University, Kagawa, Japan
Invest Ophthalmol Vis Sci 53:4099-110. 2012
..To investigate the mechanism of the neuroprotective effects of the angiotensin II type 1 receptor (AT1-R) blocker against retinal ischemia-reperfusion injury in the rat...
- 25-gauge vs 20-gauge system for pars plana vitrectomy: a prospective randomised clinical trial
Department of Ophthalmology, Rudolph Foundation Clinic, Vienna, Austria
Br J Ophthalmol 91:945-8. 2007
..To compare 25-gauge vs 20-gauge system for pars plana vitrectomy in a prospective, randomised, controlled clinical trial...
- A novel antiangiogenic and vascular normalization therapy targeted against human CD160 receptor
Institut National de la Santé et de la Recherche Médicale U1043, F 31300 Toulouse, France
J Exp Med 208:973-86. 2011
..These studies validate CD160 as a potential new target in cases of human pathological ocular and tumor neoangiogenesis that do not respond or become resistant to existing antiangiogenic drugs...
- STAT3 activation protects retinal ganglion cell layer neurons in response to stress
Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA
Exp Eye Res 86:991-7. 2008
..Our results suggest that persistent activation of STAT3 by neurotrophic factors provides strong neuroprotection and will be an effective strategy in a number of chronic retinal diseases.
- The spectrum of retinopathy in adults with Plasmodium falciparum malaria
Richard J Maude
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Trans R Soc Trop Med Hyg 103:665-71. 2009
..Portable retinal photography has potential as a valuable tool to study malarial retinopathy...
- Canine CNGB3 mutations establish cone degeneration as orthologous to the human achromatopsia locus ACHM3
Duska J Sidjanin
Center for Canine Genetics and Reproduction, James A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Hum Mol Genet 11:1823-33. 2002
- Inducible nitric oxide synthase mediates retinal apoptosis in ischemic proliferative retinopathy
Developpement, Vieillissement et Pathologie de la Retine, Institut National de la Santé et de la Recherche Médicale U450, Association Claude Bernard, 75270 Paris Cedex 06, France
J Neurosci 22:3987-93. 2002
..We show that it is an ideal target to protect the hypoxic retina from degeneration and to improve its vascularization...
- Autoimmunity in retinal degeneration: autoimmune retinopathy and age-related macular degeneration
Dobbs Ocular Immunology Laboratories, Emory Eye Center and Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA 30322, USA
J Autoimmun 33:247-54. 2009
..Finally, we outline unanswered questions and exciting areas of future study related to autoimmune retinal degeneration...
- The expanded clinical spectrum of deferoxamine retinopathy
Department of Ophthalmology, Boston University School of Medicine, DOB 10 720 Harrison Avenue, Boston, MA 02118, USA
Ophthalmology 109:164-71. 2002
..To describe early and unusual features in 16 patients with deferoxamine-induced retinal toxicity and to assess the role of diagnostic tests in the diagnosis and management of patients with the disorder...
- Prevalence of vitreoretinal disorders in a rural population of southern India: the Aravind Comprehensive Eye Study
Praveen K Nirmalan
Aravind Medical Research Foundation, Aravind Eye Care System, Madurai, India
Arch Ophthalmol 122:581-6. 2004
..To determine the magnitude of vitreoretinal disorders in a rural southern Indian population...
- Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells
Laboratory for Retinal Regeneration, Center for Developmental Biology, RIKEN, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe, 650 0047, Japan
Nat Biotechnol 26:215-24. 2008
..Subsequent treatment with retinoic acid and taurine induced photoreceptor differentiation. These findings may facilitate the development of human ES cell-based transplantation therapies for retinal diseases.
- The cis-regulatory logic of the mammalian photoreceptor transcriptional network
Timothy H C Hsiau
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, United States of America
PLoS ONE 2:e643. 2007
..This study represents the first systematic identification and in vivo validation of CREs in a mammalian neuronal cell type and lays the groundwork for a systems biology of photoreceptor transcriptional regulation...
- Blood-retinal barrier disruption and ultrastructural changes in the hypoxic retina in adult rats: the beneficial effect of melatonin administration
Department of Anatomy, Yong Loo Lin School of Medicine, Blk MD10, 4 Medical Drive, National University of Singapore, Singapore 117597
J Pathol 212:429-39. 2007
- Leukocytes mediate retinal vascular remodeling during development and vaso-obliteration in disease
Angiogenesis Retina Research Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 325 Cambridge Street, Boston, Massachusetts 02114, USA
Nat Med 9:781-8. 2003
..Targeting these pathways may prove useful in the treatment of retinal ischemia, a leading cause of vision loss and blindness...
- The role of vitamin E and oxidative stress in diabetes complications
Department of Foods and Nutrition, Purdue University, 700 West State Street, West Lafayette, IN 47907, USA
Mech Ageing Dev 131:276-86. 2010
..More studies are required to make definitive conclusions about the effect of vitamin E treatment on diabetes complications in human subjects...
- Clinical application of rapid serial fourier-domain optical coherence tomography for macular imaging
Department of Ophthalmology and Vision Science, University of California Davis, Sacramento, California 95817, USA
Ophthalmology 113:1425-31. 2006
..To introduce and examine the utility of a retinal imaging technique using high-speed optical coherence tomography (OCT) for creating a more complete retinal structural map to aid in the evaluation of patients with macular pathology...
- Fundus autofluorescence imaging: review and perspectives
Department of Ophthalmology, University of Bonn, Bonn, Germany
Retina 28:385-409. 2008
..epithelium cells represents a common downstream pathogenetic pathway in various hereditary and complex retinal diseases, including age-related macular degeneration...
- Spectral-domain optical coherence tomography with multiple B-scan averaging for enhanced imaging of retinal diseases
Department of Ophthalmology and Visual Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
Ophthalmology 115:1071-1078.e7. 2008
..To determine whether multiple B-scan averaging improves the quality of spectral-domain optical coherence tomography (SD OCT) images of the retina...
- Differential expression of pro- and antiangiogenic factors in mouse strain-dependent hypoxia-induced retinal neovascularization
Candy K Chan
Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Lab Invest 85:721-33. 2005
..02). Strain-dependent expression of both pro- and antiangiogenic growth factors may determine heterogeneity in the angiogenic response and potentially, susceptibility to angiogenesis-dependent diseases...
- Associations between the metabolic syndrome and retinal microvascular signs: the Atherosclerosis Risk In Communities study
Tien Yin Wong
Centre for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia
Invest Ophthalmol Vis Sci 45:2949-54. 2004
..To examine the cross-sectional relationship of the metabolic syndrome (hypertension, hyperglycemia, central obesity, and dyslipidemia) and retinal microvascular abnormalities in middle-aged men and women...
- Origin and turnover of ECM proteins from the inner limiting membrane and vitreous body
Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 14262, USA
Eye (Lond) 22:1207-13. 2008
..Our data explain why ILM and VB do not regenerate after vitrectomy and ILM peeling...
- Alterations in retinal microvascular geometry in young type 1 diabetes
Muhammad Bayu Sasongko
Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, Australia
Diabetes Care 33:1331-6. 2010
..To describe retinal microvascular geometric parameters in young patients with type 1 diabetes...
- Effect of an inducer of BiP, a molecular chaperone, on endoplasmic reticulum (ER) stress-induced retinal cell death
Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, Gifu, Japan
Invest Ophthalmol Vis Sci 50:334-44. 2009
- RPE transplantation and its role in retinal disease
Lyndon da Cruz
Division of Cellular Therapy, Institute of Ophthalmology, 11 43 Bath Street, London EC1V 9EL, UK
Prog Retin Eye Res 26:598-635. 2007
..in the Royal College of Surgeons (RCS) rat and in humans, photoreceptor dystrophies as well as complex retinal diseases such as atrophic and neovascular age-related macular degeneration (AMD)...
- Evaluation of image artifact produced by optical coherence tomography of retinal pathology
Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina 27710, USA
Am J Ophthalmol 139:18-29. 2005
..To determine the frequency and type of optical coherence tomography (OCT) fast macular thickness map (FMTM) scan artifacts, and whether these artifacts depend on patient diagnosis, demographics, and ocular therapy...
- Mitochondrial dysfunction in retinal diseases
School of Pharmacy, University of Missouri Kansas City, Kansas City, MO 64108, USA
Curr Eye Res 36:1069-77. 2011
..review highlights the role of mitochondrial dysfunction originating from oxidative stress in the etiology of retinal diseases including diabetic retinopathy, glaucoma and age-related macular degeneration (AMD)...
- The eye in hypertension
Tien Yin Wong
Centre for Eye Research Australia, University of Melbourne, Australia
Lancet 369:425-35. 2007
..Recognition of the ocular effects of blood pressure could allow physicians to better manage patients with hypertension, and to monitor its end-organ effects...
- RPE lipofuscin and its role in retinal pathobiology
Janet R Sparrow
Department of Ophthalmology, Columbia University, 630 W 168th Street, New York, NY 10032, USA
Exp Eye Res 80:595-606. 2005
..Since recent findings with respect to the origin, composition and adverse effects of RPE lipofuscin have informed our view of this material, the goal of this article is to review our current understanding of these issues...
- Retinal angiogenesis in development and disease
Ray F Gariano
Department of Ophthalmology, A 157, 300 Pasteur Drive, Stanford University School of Medicine, Palo Alto, California 94305, USA
Nature 438:960-6. 2005
..The retina and its clinical disorders have a pivotal role in angiogenesis research and provide model systems in which to investigate neurovascular relationships and angiogenic diseases...
- Spare the rod and spoil the eye
G B Arden
Henry Wellcome Laboratories, Applied Vision Research Centre, Department of Optometry and Visual Science, City University, Northampton Square, London EC1V 0HB, UK
Br J Ophthalmol 89:764-9. 2005
- Memantine blocks mitochondrial OPA1 and cytochrome c release and subsequent apoptotic cell death in glaucomatous retina
Won Kyu Ju
Hamilton Glaucoma Center, University of California San Diego, La Jolla, California 92037, USA
Invest Ophthalmol Vis Sci 50:707-16. 2009
- Retinal inner nuclear layer microcystic changes in optic nerve atrophy: a novel spectral-domain OCT finding
Rothschild Ophthalmologic Foundation, Paris, France and Centre Ophtalmologique Rabelais, Lyon, France
Retina 33:2133-8. 2013
..Optic atrophy constitutes the final stage in the evolution of optic neuropathy. The aim of this study was to describe the presence of macular microcystic changes or pseudocysts in patients with advanced optic atrophy...
- Metabolic effects of hypothermia and its neuroprotective effects on the recovery of metabolic and electrophysiological function in the ischemic retina in vitro
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
Neurosurgery 52:1178-86; discussion 1186-7. 2003
..We describe experiments using hypothermia in the rabbit retina in vitro that show a correlation between hypothermia-induced reductions in energy usage and neuroprotection...
- Pleiotropic effects of YC-1 selectively inhibit pathological retinal neovascularization and promote physiological revascularization in a mouse model of oxygen-induced retinopathy
Research Department, King Khaled Eye Specialist Hospital, Aruba Street, P O Box 7191, Riyadh 11462, Kingdom of Saudi Arabia
Mol Pharmacol 77:348-67. 2010
..The pleiotropic effects of YC-1 allude to its possible use as a promising therapeutic iNOS inhibitor candidate for the treatment of retinal neovascularization...
- Slowly progressive cancer-associated retinopathy
Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Nishi 7 chome, Kita 15 jou, Kita ku, Sapporo 060 8638, Japan
Arch Ophthalmol 125:1431-3. 2007
- Translating induced pluripotent stem cells from bench to bedside: application to retinal diseases
Alona O Cramer
Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neuroscience, NIHR Biomedical Research Centre, University of Oxford, Oxford OX3 9DU, UK
Curr Gene Ther 13:139-51. 2013
- Intravitreal triamcinolone
Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht Karls University, Heidelberg, Germany
Ophthalmologica 225:1-20. 2011
..to provide an update on the intravitreal use of triamcinolone acetonide...
- Rates and predictors of hydroxychloroquine retinal toxicity in patients with rheumatoid arthritis and systemic lupus erythematosus
National Data Bank for Rheumatic Diseases and University of Kansas School of Medicine, Wichita, KS 67214, USA
Arthritis Care Res (Hoboken) 62:775-84. 2010
..We have studied the largest unselected series of patients to date to evaluate the risk of toxicity and the relevance of purported risk factors...
- Comparison of screening procedures in hydroxychloroquine toxicity
Michael F Marmor
Department of Ophthalmology, Stanford University School of Medicine, Byers Eye Institute at Stanford, 2452 Watson Ct, Palo Alto, CA 94303 5353, USA
Arch Ophthalmol 130:461-9. 2012
..To compare different screening procedures for hydroxychloroquine sulfate (Plaquenil) toxicity at different stages of damage...
- Detection and monitoring of sickle cell retinopathy using ultra wide-field color photography and fluorescein angiography
Department of Ophthalmology, Weill Cornell Medical College, New York, New York 10021, USA
Retina 31:738-47. 2011
..In this study, we demonstrate the use of wide-field photography and fluorescein angiography to visualize the peripheral vascular changes and to identify patients with risk factors for developing proliferative sickle cell retinopathy...
- Retinal vessel diameters and risk of hypertension: the Multiethnic Study of Atherosclerosis
Department of Ophthalmology, Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, Australia
J Hypertens 27:2386-93. 2009
..To describe the prospective relationship of retinal vessel diameters with risk of hypertension in a multiethnic population-based cohort...
- Transcriptional code and disease map for adult retinal cell types
Neural Circuit Laboratories, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
Nat Neurosci 15:487-95, S1-2. 2012
- Astroglial NF-κB mediates oxidative stress by regulation of NADPH oxidase in a model of retinal ischemia reperfusion injury
David J Barakat
Department of Molecular, Cell and Developmental Biology, University of Miami Miller School of Medicine, Miami, Florida, USA
J Neurochem 120:586-97. 2012
..Collectively, our results suggest that astroglial NF-κB-regulated PHOX activity is a crucial toxicity pathway in the pathogenesis of retinal IR injury...
- Gene deletion and pharmacological inhibition of aldose reductase protect against retinal ischemic injury
Alvin K H Cheung
Department of Anatomy, The University of Hong Kong, Pokfulam Road, Hong Kong, China
Exp Eye Res 85:608-16. 2007
..Therefore, AR inhibition should be considered for the treatment of retinal ischemic injury often observed in diabetic patients...
- Microplasmin intravitreal administration in patients with vitreomacular traction scheduled for vitrectomy: the MIVI I trial
Marc D de Smet
Department of Ophthalmology, ZNA Middelheim Campus, Antwerp, Belgium
Ophthalmology 116:1349-55, 1355.e1-2. 2009
..To evaluate the safety and preliminary efficacy of 4 doses and several exposure times of intravitreal microplasmin given before pars plana vitrectomy for vitreomacular traction maculopathy...
- Surgical outcomes of epiretinal membranes associated with combined hamartoma of the retina and retinal pigment epithelium
Aaron D Cohn
Beaumont Eye Institute, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
Retina 29:825-30. 2009
- Retinal arteriolar caliber and urine albumin excretion: the Multi-Ethnic Study of Atherosclerosis
Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Nephrol Dial Transplant 26:3523-8. 2011
..Changes in retinal microvascular caliber, which occur prior to onset of retinopathy, may indicate presence of kidney damage...
- Transconjunctival sutureless 23-gauge vitrectomy
Department of Ophthalmology, Staedtische Kliniken Frankfurt am Main Hoechst, Frankfurt, Germany
Retina 25:208-11. 2005
- An atypical form of Bietti crystalline dystrophy
Department of Ophthalmology, Second University of Naples, Napoli, Italy
Ophthalmic Genet 32:118-21. 2011
..To describe clinical and functional features of a patient with Bietti crystalline dystrophy and atypical electroretinogram responses...
- A selective inhibitor of drp1, mdivi-1, increases retinal ganglion cell survival in acute ischemic mouse retina
Sang Woo Park
Sophie and Arthur Brody Optic Nerve Laboratory, Hamilton Glaucoma Center, University of California San Diego, La Jolla, California 92037, USA
Invest Ophthalmol Vis Sci 52:2837-43. 2011
- Dietary hyperglycemia, glycemic index and metabolic retinal diseases
Chung Jung Chiu
Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Department of Ophthalmology, School of Medicine, Tufts University, 711 Washington Street, Boston, MA 02111, United States
Prog Retin Eye Res 30:18-53. 2011
..In this context, these diseases can be considered as metabolic retinal diseases. Molecular theories that explain hyperglycemic pathogenesis involve a mitochondria-associated pathway and ..
- Effects of ischemia-reperfusion on physiological properties of Müller glial cells in the porcine retina
Paul Flechsig Institut für Hirnforschung, Universitat Leipzig, Jahnallee 59, 04109 Leipzig, Germany
Invest Ophthalmol Vis Sci 52:3360-7. 2011
..A viable animal model for human ischemic events should display similarities in eye size and retinal blood supply. Therefore, pigs were used in this investigation of physiological alterations in Müller cells after ischemia-reperfusion...
- Short communication: PPAR gamma mediates a direct antiangiogenic effect of omega 3-PUFAs in proliferative retinopathy
Department of Ophthalmology, Harvard Medical School, Children s Hospital, Boston, Mass 02115, USA
Circ Res 107:495-500. 2010
..Omega3 long-chain polyunsaturated fatty acids (omega3-PUFAs) are powerful modulators of angiogenesis. However, little is known about the mechanisms governing omega3-PUFA-dependent attenuation of angiogenesis...
- Neuroglobin protection in retinal ischemia
Anita S Y Chan
Doheny Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Invest Ophthalmol Vis Sci 53:704-11. 2012
..To explore the role of Ngb in retinal neuroprotection during ischemia reperfusion (IR), the authors examined the effect of Ngb overexpression in the retina in vivo by using Ngb-transgenic (Ngb-Tg) mice...
- Identification of autoantibodies against TRPM1 in patients with paraneoplastic retinopathy associated with ON bipolar cell dysfunction
Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
PLoS ONE 6:e19911. 2011
..The purpose of the current study is to investigate whether there are autoantibodies against TRPM1 in the sera of PR patients exhibiting ON bipolar cell dysfunction...
- Protective effects of catalase on retinal ischemia/reperfusion injury in rats
Department of Ophthalmology, Second Xiangya Hospital, Central South University, 139 Renming Middle Road, Changsha Hunan Province 410011, PR China
Exp Eye Res 93:599-606. 2011
- Surgical management of epiretinal membrane in combined hamartomas of the retina and retinal pigment epithelium
Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
Retina 30:305-9. 2010
..The purpose of this study was to evaluate the surgical outcome of combined hamartomas of the retina and retinal pigment epithelium in five patients...
- 15-year cumulative incidence and associated risk factors for retinopathy in nondiabetic persons
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, 53726, USA
Arch Ophthalmol 128:1568-75. 2010
..To investigate the relationship of systemic factors to the 15-year cumulative incidence of retinopathy in nondiabetic persons in the Beaver Dam Eye Study...
- Optical coherence tomographic findings of combined hamartoma of the retina and retinal pigment epithelium in 11 patients
Carol L Shields
Ocular Oncology Service, Wills Eye Hospital, 840 Walnut St, Philadelphia, PA 19107, USA
Arch Ophthalmol 123:1746-50. 2005
- PIII and derived PII analysis in a patient with retinal dysfunction with supernormal scotopic ERG
Division of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Niigata University, 1 757, Asahimachi, Niigata, 951 8510, Japan
Doc Ophthalmol 110:219-26. 2005
..To present electroretinographic (ERG) findings in a patient with retinal dysfunction with supernormal scotopic ERG, and to analyze rod and cone PIII components and rod inner nuclear layer (derived PII) responses...
- Repeatability of in vivo parafoveal cone density and spacing measurements
Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Optom Vis Sci 89:632-43. 2012
..To assess the repeatability and measurement error associated with cone density and nearest neighbor distance (NND) estimates in images of the parafoveal cone mosaic obtained with an adaptive optics scanning light ophthalmoscope (AOSLO)...
- The value of measurement of macular carotenoid pigment optical densities and distributions in age-related macular degeneration and other retinal disorders
Paul S Bernstein
Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT, USA
Vision Res 50:716-28. 2010