retinal diseases

Summary

Top Publications

  1. ncbi Retinal ischemia: mechanisms of damage and potential therapeutic strategies
    Neville N Osborne
    Nuffield Laboratory of Ophthalmology, University of Oxford, Walton Street, Oxford OX2 6AW, UK
    Prog Retin Eye Res 23:91-147. 2004
  2. ncbi The genomic response to retinal disease and injury: evidence for endothelin signaling from photoreceptors to glia
    Amir Rattner
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 25:4540-9. 2005
  3. pmc Genetic and phenotypic variations of inherited retinal diseases in dogs: the power of within- and across-breed studies
    Keiko Miyadera
    Section of Ophthalmology, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, 3900 Delancey St, Philadelphia, PA 19104, USA
    Mamm Genome 23:40-61. 2012
  4. doi Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model
    Daniel M Rosenbaum
    Department of Neurology, SUNY Downstate Medical Center, Brooklyn, New York, USA
    J Neurosci Res 88:1569-76. 2010
  5. ncbi Retinal microvascular abnormalities and incident stroke: the Atherosclerosis Risk in Communities Study
    T Y Wong
    Department of Ophthalmology, University of Wisconsin, Madison, WI 53705 2397, USA
    Lancet 358:1134-40. 2001
  6. pmc Optic vesicle-like structures derived from human pluripotent stem cells facilitate a customized approach to retinal disease treatment
    Jason S Meyer
    Waisman Center, University of Wisconsin, Madison, Wisconsin, USA
    Stem Cells 29:1206-18. 2011
  7. ncbi Distribution, markers, and functions of retinal microglia
    Ling Chen
    Zhongshan Ophthalmic Center, Sun Yat Sen University of Medical Sciences, Guangzhou, P R China
    Ocul Immunol Inflamm 10:27-39. 2002
  8. pmc Perfusion abnormalities in children with cerebral malaria and malarial retinopathy
    Nicholas A V Beare
    St Paul s Eye Unit, Royal Liverpool University Hospital, Prescot Street, Liverpool, United Kingdom
    J Infect Dis 199:263-71. 2009
  9. ncbi Retinopathy and attenuated circadian entrainment in Crx-deficient mice
    T Furukawa
    Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, USA
    Nat Genet 23:466-70. 1999
  10. ncbi State-of-the-art retinal optical coherence tomography
    Wolfgang Drexler
    Biomedical Imaging Group, School of Optometry and Vision Sciences, Cardiff University, Maindy Road, CF24 4LU, Wales, United Kingdom
    Prog Retin Eye Res 27:45-88. 2008

Detail Information

Publications300 found, 100 shown here

  1. ncbi Retinal ischemia: mechanisms of damage and potential therapeutic strategies
    Neville N Osborne
    Nuffield Laboratory of Ophthalmology, University of Oxford, Walton Street, Oxford OX2 6AW, UK
    Prog Retin Eye Res 23:91-147. 2004
    ..Given the increasing understanding of the events involved in ischemic neuronal injury it is hoped that clinically effective treatments for retinal ischemia will soon be available...
  2. ncbi The genomic response to retinal disease and injury: evidence for endothelin signaling from photoreceptors to glia
    Amir Rattner
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 25:4540-9. 2005
    ....
  3. pmc Genetic and phenotypic variations of inherited retinal diseases in dogs: the power of within- and across-breed studies
    Keiko Miyadera
    Section of Ophthalmology, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, 3900 Delancey St, Philadelphia, PA 19104, USA
    Mamm Genome 23:40-61. 2012
    ..Different forms of retinal diseases occur in specific breed(s) caused by mutations segregating within each isolated breeding population...
  4. doi Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model
    Daniel M Rosenbaum
    Department of Neurology, SUNY Downstate Medical Center, Brooklyn, New York, USA
    J Neurosci Res 88:1569-76. 2010
    ..Necroptosis is programmed necrosis triggered by death receptor signaling. We investigated whether necroptosis contributes to neuronal damage and functional impairment in a model of retinal ischemia...
  5. ncbi Retinal microvascular abnormalities and incident stroke: the Atherosclerosis Risk in Communities Study
    T Y Wong
    Department of Ophthalmology, University of Wisconsin, Madison, WI 53705 2397, USA
    Lancet 358:1134-40. 2001
    ..Retinal microvascular abnormalities reflect damage from hypertension and other vascular processes. We examined the relation of such abnormalities to incident stroke...
  6. pmc Optic vesicle-like structures derived from human pluripotent stem cells facilitate a customized approach to retinal disease treatment
    Jason S Meyer
    Waisman Center, University of Wisconsin, Madison, Wisconsin, USA
    Stem Cells 29:1206-18. 2011
    ..The production of OV-like populations from human pluripotent stem cells should facilitate the study of human retinal development and disease and advance the use of hiPSCs in personalized medicine...
  7. ncbi Distribution, markers, and functions of retinal microglia
    Ling Chen
    Zhongshan Ophthalmic Center, Sun Yat Sen University of Medical Sciences, Guangzhou, P R China
    Ocul Immunol Inflamm 10:27-39. 2002
    ..The goal of this article was to review the present knowledge about retinal microglia and the function of retinal microglia in pathological conditions...
  8. pmc Perfusion abnormalities in children with cerebral malaria and malarial retinopathy
    Nicholas A V Beare
    St Paul s Eye Unit, Royal Liverpool University Hospital, Prescot Street, Liverpool, United Kingdom
    J Infect Dis 199:263-71. 2009
    ..We aimed to examine retinal perfusion in children with CM by use of fluorescein angiography to investigate the pathophysiology of CM...
  9. ncbi Retinopathy and attenuated circadian entrainment in Crx-deficient mice
    T Furukawa
    Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, USA
    Nat Genet 23:466-70. 1999
    ..Mutations in human CRX are associated with the retinal diseases, cone-rod dystrophy-2 (adCRD2; refs 3, 4, 5), retinitis pigmentosa (RP) and Leber congenital amaurosis (LCA), ..
  10. ncbi State-of-the-art retinal optical coherence tomography
    Wolfgang Drexler
    Biomedical Imaging Group, School of Optometry and Vision Sciences, Cardiff University, Maindy Road, CF24 4LU, Wales, United Kingdom
    Prog Retin Eye Res 27:45-88. 2008
    ..Functional OCT promises to enable the differentiation of retinal pathologies via localized, functional retinal response or metabolic properties. These advances promise to have a powerful impact on fundamental as well as clinical studies...
  11. ncbi Relationship of retinal vascular caliber with diabetes and retinopathy: the Multi-Ethnic Study of Atherosclerosis (MESA)
    Thanh Tan Nguyen
    Centre for Eye Research Australia, University of Melbourne, 32 Gisborne Street, Victoria 3002, Australia
    Diabetes Care 31:544-9. 2008
    ..To examine the relationship of retinal vascular caliber with diabetes, glycemia, and diabetic retinopathy...
  12. pmc Protective effects of human iPS-derived retinal pigment epithelium cell transplantation in the retinal dystrophic rat
    Amanda Jayne Carr
    Department of Ocular Biology and Therapeutics, Institute of Ophthalmology, University College London, London, United Kingdom
    PLoS ONE 4:e8152. 2009
    ..These findings have identified an alternative source of replacement tissue for use in human retinal cellular therapies, and provide a new in vitro cellular model system in which to study RPE diseases affecting human patients...
  13. pmc Irish setter dogs affected with rod/cone dysplasia contain a nonsense mutation in the rod cGMP phosphodiesterase beta-subunit gene
    M L Suber
    College of Optometry, University of Houston, TX 77204
    Proc Natl Acad Sci U S A 90:3968-72. 1993
    ....
  14. doi Ophthalmic drug discovery: novel targets and mechanisms for retinal diseases and glaucoma
    Kang Zhang
    Department of Ophthalmology and Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
    Nat Rev Drug Discov 11:541-59. 2012
    ..This Review discusses the current state of ocular drug therapy and highlights future therapeutic opportunities...
  15. ncbi Relationships between age, blood pressure, and retinal vessel diameters in an older population
    Harry Leung
    Department of Ophthalmology, Centre for Vision Research, and the Westmead Millennium and Save Sight Institutes, The University of Sydney, NSW, Australia
    Invest Ophthalmol Vis Sci 44:2900-4. 2003
    ..To describe the cross-sectional relationships between age, blood pressure (BP), and quantitative measures of retinal vessel diameters in an older Australian population...
  16. pmc Development and application of a next-generation-sequencing (NGS) approach to detect known and novel gene defects underlying retinal diseases
    Isabelle Audo
    INSERM, U968, Paris, F 75012, France
    Orphanet J Rare Dis 7:8. 2012
    ..However, these methods are time consuming, expensive and unable to provide a result if the patient carries a new gene mutation. In addition, multiplicity of phenotypes associated with the same gene defect may be overlooked...
  17. pmc Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis
    Kip M Connor
    Department of Ophthalmology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    Nat Protoc 4:1565-73. 2009
    ..In this protocol we describe standards for mouse size, sample size, retinal preparation, quantification of vascular loss, vascular regrowth, NV and neovascular regression...
  18. ncbi Retinal microvascular abnormalities and their relationship with hypertension, cardiovascular disease, and mortality
    T Y Wong
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53705 2397, USA
    Surv Ophthalmol 46:59-80. 2001
    ..When reliably quantified, retinal microvascular abnormalities may be useful as risk indicators for cerebrovascular diseases...
  19. ncbi Increased dietary intake of omega-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis
    Kip M Connor
    Department of Ophthalmology, Harvard Medical School, Children s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Med 13:868-73. 2007
    ..Supplementing omega-3-PUFA intake may be of benefit in preventing retinopathy...
  20. ncbi Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography
    Wolfgang Drexler
    Department of Medical Physics, University of Vienna, Christian Doppler Laboratory, Austria
    Arch Ophthalmol 121:695-706. 2003
    ....
  21. ncbi Retinal vessel diameter and cardiovascular mortality: pooled data analysis from two older populations
    Jie Jin Wang
    Centre for Vision Research, Department of Ophthalmology, Westmead Hospital, and the Westmead Millennium Institute, University of Sydney, Australia
    Eur Heart J 28:1984-92. 2007
    ..The retinal microvasculature may reflect pre-clinical changes in the cerebral and coronary microcirculations. We assessed whether smaller retinal arterioles and larger venules predicted coronary heart disease (CHD)- and stroke-mortality...
  22. doi Retinal vascular caliber: systemic, environmental, and genetic associations
    Cong Sun
    Centre for Eye Research Australia, University of Melbourne, Victoria, Australia
    Surv Ophthalmol 54:74-95. 2009
    ....
  23. doi Modulation of pro-survival and death-associated pathways under retinal ischemia/reperfusion: effects of NMDA receptor blockade
    R Russo
    Department of Pharmacobiology, Section of Neuropharmacology of Normal and Pathological Neuronal Plasticity, University of Calabria, Arcavacata di Rende, Italy
    J Neurochem 107:1347-57. 2008
    ..In addition, these data implicate the pro-survival PI3K/Akt pathway and the observed reduced expression of Bad in the neuroprotection afforded by MK801...
  24. doi Retinal toxicity associated with hydroxychloroquine and chloroquine: risk factors, screening, and progression despite cessation of therapy
    Michel Michaelides
    Oregon Retinal Degeneration Center, Casey Eye Institute, Oregon Health and Science University, Portland, OR 97239 4197, USA
    Arch Ophthalmol 129:30-9. 2011
    ..To report the detailed clinical findings of patients with retinal toxicity that developed secondary to the use of hydroxychloroquine sulfate (n = 13), chloroquine phosphate (n = 2), or a combination of the agents (n = 1)...
  25. pmc Myeloid progenitors differentiate into microglia and promote vascular repair in a model of ischemic retinopathy
    Matthew R Ritter
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Clin Invest 116:3266-76. 2006
    ..These findings suggest what we believe to be a novel therapeutic approach for the treatment of ischemic retinopathies that promotes vascular repair rather than destruction...
  26. ncbi Retinal microvascular abnormalities and 10-year cardiovascular mortality: a population-based case-control study
    Tien Yin Wong
    Singapore National Eye Center and National University of Singapore, Singapore, Republic of Singapore
    Ophthalmology 110:933-40. 2003
    ..Retinal microvascular abnormalities reflect persistent arteriolar damage from hypertension and independently predict stroke. We examined their associations with long-term cardiovascular mortality...
  27. doi Neuroprotection against retinal ischemia-reperfusion injury by blocking the angiotensin II type 1 receptor
    Kouki Fukuda
    Departments of Ophthalmology, Kagawa University Faculty of Medicine, Kagawa, Japan
    Invest Ophthalmol Vis Sci 51:3629-38. 2010
    ..Both the ACE inhibitor and the AT1-R antagonist that were examined can block the stimulation of the AT1-R and attenuate the subsequent ischemic damage in the rat retina...
  28. pmc Identification of malaria retinopathy improves the specificity of the clinical diagnosis of cerebral malaria: findings from a prospective cohort study
    Gretchen L Birbeck
    International Neurologic and Psychiatric Epidemiology Program, Michigan State University, East Lansing, Michigan, USA
    Am J Trop Med Hyg 82:231-4. 2010
    ..This subset of patients may represent children with a pre-existing propensity to adverse neurologic symptoms and outcomes...
  29. pmc Autoantibodies in melanoma-associated retinopathy target TRPM1 cation channels of retinal ON bipolar cells
    Anuradha Dhingra
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 31:3962-7. 2011
    ..We conclude that the vision of at least some patients with MAR is compromised due to autoantibody-mediated inactivation of the TRPM1 channel...
  30. ncbi Polypoidal choroidal vasculopathy with choroidal vascular hyperpermeability
    Manabu Sasahara
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Am J Ophthalmol 142:601-7. 2006
    ..To describe the incidence and clinical characteristics of polypoidal choroidal vasculopathy (PCV) associated with choroidal vascular hyperpermeability...
  31. doi Ligation of the pterygopalatine and external carotid arteries induces ischemic damage in the murine retina
    Hiromi Ogishima
    Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu, Japan
    Invest Ophthalmol Vis Sci 52:9710-20. 2011
    ..This study aimed to characterize the functional and morphologic changes in a murine model of ocular ischemic disease caused by vascular occlusion...
  32. doi Pluripotent human stem cells for the treatment of retinal disease
    Teisha J Rowland
    Center for Stem Cell Biology and Engineering, University of California, Santa Barbara, California, USA
    J Cell Physiol 227:457-66. 2012
    Despite advancements made in our understanding of ocular biology, therapeutic options for many debilitating retinal diseases remain limited...
  33. pmc Risk prediction of coronary heart disease based on retinal vascular caliber (from the Atherosclerosis Risk In Communities [ARIC] Study)
    Kevin McGeechan
    School of Public Health, University of Sydney, Sydney, Australia
    Am J Cardiol 102:58-63. 2008
    ..In conclusion, although retinal vascular caliber independently predicted CHD risk in women, the incremental predictive ability over that of the Framingham model was modest and unlikely to translate meaningfully into clinical practice...
  34. ncbi In vivo confocal imaging of the retina in animal models using scanning laser ophthalmoscopy
    Mathias W Seeliger
    Retinal Diagnostics Research Group, Tuebingen, Germany
    Vision Res 45:3512-9. 2005
    ..Important fields of application are studies in retinal degenerations and the follow-up of therapeutic intervention...
  35. doi Pathophysiology of stroke and stroke-induced retinal ischemia: emerging role of stem cells
    Rupadevi Muthaian
    Department of Neurology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
    J Cell Physiol 227:1269-79. 2012
    ..In this review, we highlight the advantages and limitations of this approach with a focus on key observations from preclinical animal studies and clinical trials. Further research, especially on treatment with EPCs is warranted...
  36. pmc High-definition and 3-dimensional imaging of macular pathologies with high-speed ultrahigh-resolution optical coherence tomography
    Vivek J Srinivasan
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Ophthalmology 113:2054.e1-14. 2006
    ..To assess high-speed ultrahigh-resolution optical coherence tomography (OCT) image resolution, acquisition speed, image quality, and retinal coverage for the visualization of macular pathologies...
  37. ncbi Retinopathy and risk of congestive heart failure
    Tien Y Wong
    Centre for Eye Research Australia, University of Melbourne, Victoria, Australia
    JAMA 293:63-9. 2005
    ..The pathogenesis of CHF is uncertain, but microvascular disease has been hypothesized as a possible factor...
  38. doi Using multifocal ERG ring ratios to detect and follow Plaquenil retinal toxicity: a review : Review of mfERG ring ratios in Plaquenil toxicity
    Jonathan S Lyons
    Georgetown University Washington National Eye Center, Washington, DC, USA
    Doc Ophthalmol 118:29-36. 2009
    ..It appears appropriate to recommend that mfERG testing be done on all patients on Plaquenil therapy...
  39. pmc Inhibition of reactive gliosis prevents neovascular growth in the mouse model of oxygen-induced retinopathy
    Michael Deniro
    Research Department, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    PLoS ONE 6:e22244. 2011
    ..In addition, the study reveals that YC-1 may exert promising therapeutic effects in the treatment of retinal and neuronal pathologies...
  40. doi Neuroprotective effects of angiotensin II type 1 receptor (AT1-R) blocker via modulating AT1-R signaling and decreased extracellular glutamate levels
    Tomoyoshi Fujita
    Department of Ophthalmology, Kagawa University, Kagawa, Japan
    Invest Ophthalmol Vis Sci 53:4099-110. 2012
    ..To investigate the mechanism of the neuroprotective effects of the angiotensin II type 1 receptor (AT1-R) blocker against retinal ischemia-reperfusion injury in the rat...
  41. pmc 25-gauge vs 20-gauge system for pars plana vitrectomy: a prospective randomised clinical trial
    Lukas Kellner
    Department of Ophthalmology, Rudolph Foundation Clinic, Vienna, Austria
    Br J Ophthalmol 91:945-8. 2007
    ..To compare 25-gauge vs 20-gauge system for pars plana vitrectomy in a prospective, randomised, controlled clinical trial...
  42. pmc A novel antiangiogenic and vascular normalization therapy targeted against human CD160 receptor
    Sophie Chabot
    Institut National de la Santé et de la Recherche Médicale U1043, F 31300 Toulouse, France
    J Exp Med 208:973-86. 2011
    ..These studies validate CD160 as a potential new target in cases of human pathological ocular and tumor neoangiogenesis that do not respond or become resistant to existing antiangiogenic drugs...
  43. doi STAT3 activation protects retinal ganglion cell layer neurons in response to stress
    Chun Zhang
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA
    Exp Eye Res 86:991-7. 2008
    ..Our results suggest that persistent activation of STAT3 by neurotrophic factors provides strong neuroprotection and will be an effective strategy in a number of chronic retinal diseases.
  44. pmc The spectrum of retinopathy in adults with Plasmodium falciparum malaria
    Richard J Maude
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Trans R Soc Trop Med Hyg 103:665-71. 2009
    ..Portable retinal photography has potential as a valuable tool to study malarial retinopathy...
  45. ncbi Canine CNGB3 mutations establish cone degeneration as orthologous to the human achromatopsia locus ACHM3
    Duska J Sidjanin
    Center for Canine Genetics and Reproduction, James A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Hum Mol Genet 11:1823-33. 2002
    ....
  46. ncbi Inducible nitric oxide synthase mediates retinal apoptosis in ischemic proliferative retinopathy
    Florian Sennlaub
    Developpement, Vieillissement et Pathologie de la Retine, Institut National de la Santé et de la Recherche Médicale U450, Association Claude Bernard, 75270 Paris Cedex 06, France
    J Neurosci 22:3987-93. 2002
    ..We show that it is an ideal target to protect the hypoxic retina from degeneration and to improve its vascularization...
  47. doi Autoimmunity in retinal degeneration: autoimmune retinopathy and age-related macular degeneration
    Kei Morohoshi
    Dobbs Ocular Immunology Laboratories, Emory Eye Center and Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Autoimmun 33:247-54. 2009
    ..Finally, we outline unanswered questions and exciting areas of future study related to autoimmune retinal degeneration...
  48. ncbi The expanded clinical spectrum of deferoxamine retinopathy
    Robert Haimovici
    Department of Ophthalmology, Boston University School of Medicine, DOB 10 720 Harrison Avenue, Boston, MA 02118, USA
    Ophthalmology 109:164-71. 2002
    ..To describe early and unusual features in 16 patients with deferoxamine-induced retinal toxicity and to assess the role of diagnostic tests in the diagnosis and management of patients with the disorder...
  49. ncbi Prevalence of vitreoretinal disorders in a rural population of southern India: the Aravind Comprehensive Eye Study
    Praveen K Nirmalan
    Aravind Medical Research Foundation, Aravind Eye Care System, Madurai, India
    Arch Ophthalmol 122:581-6. 2004
    ..To determine the magnitude of vitreoretinal disorders in a rural southern Indian population...
  50. doi Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells
    Fumitaka Osakada
    Laboratory for Retinal Regeneration, Center for Developmental Biology, RIKEN, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe, 650 0047, Japan
    Nat Biotechnol 26:215-24. 2008
    ..Subsequent treatment with retinoic acid and taurine induced photoreceptor differentiation. These findings may facilitate the development of human ES cell-based transplantation therapies for retinal diseases.
  51. pmc The cis-regulatory logic of the mammalian photoreceptor transcriptional network
    Timothy H C Hsiau
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 2:e643. 2007
    ..This study represents the first systematic identification and in vivo validation of CREs in a mammalian neuronal cell type and lays the groundwork for a systems biology of photoreceptor transcriptional regulation...
  52. ncbi Blood-retinal barrier disruption and ultrastructural changes in the hypoxic retina in adult rats: the beneficial effect of melatonin administration
    C Kaur
    Department of Anatomy, Yong Loo Lin School of Medicine, Blk MD10, 4 Medical Drive, National University of Singapore, Singapore 117597
    J Pathol 212:429-39. 2007
    ....
  53. ncbi Leukocytes mediate retinal vascular remodeling during development and vaso-obliteration in disease
    Susumu Ishida
    Angiogenesis Retina Research Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 325 Cambridge Street, Boston, Massachusetts 02114, USA
    Nat Med 9:781-8. 2003
    ..Targeting these pathways may prove useful in the treatment of retinal ischemia, a leading cause of vision loss and blindness...
  54. doi The role of vitamin E and oxidative stress in diabetes complications
    Robert Pazdro
    Department of Foods and Nutrition, Purdue University, 700 West State Street, West Lafayette, IN 47907, USA
    Mech Ageing Dev 131:276-86. 2010
    ..More studies are required to make definitive conclusions about the effect of vitamin E treatment on diabetes complications in human subjects...
  55. pmc Clinical application of rapid serial fourier-domain optical coherence tomography for macular imaging
    Suhail Alam
    Department of Ophthalmology and Vision Science, University of California Davis, Sacramento, California 95817, USA
    Ophthalmology 113:1425-31. 2006
    ..To introduce and examine the utility of a retinal imaging technique using high-speed optical coherence tomography (OCT) for creating a more complete retinal structural map to aid in the evaluation of patients with macular pathology...
  56. doi Fundus autofluorescence imaging: review and perspectives
    Steffen Schmitz-Valckenberg
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Retina 28:385-409. 2008
    ..epithelium cells represents a common downstream pathogenetic pathway in various hereditary and complex retinal diseases, including age-related macular degeneration...
  57. ncbi Spectral-domain optical coherence tomography with multiple B-scan averaging for enhanced imaging of retinal diseases
    Atsushi Sakamoto
    Department of Ophthalmology and Visual Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Ophthalmology 115:1071-1078.e7. 2008
    ..To determine whether multiple B-scan averaging improves the quality of spectral-domain optical coherence tomography (SD OCT) images of the retina...
  58. ncbi Differential expression of pro- and antiangiogenic factors in mouse strain-dependent hypoxia-induced retinal neovascularization
    Candy K Chan
    Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Lab Invest 85:721-33. 2005
    ..02). Strain-dependent expression of both pro- and antiangiogenic growth factors may determine heterogeneity in the angiogenic response and potentially, susceptibility to angiogenesis-dependent diseases...
  59. ncbi Associations between the metabolic syndrome and retinal microvascular signs: the Atherosclerosis Risk In Communities study
    Tien Yin Wong
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia
    Invest Ophthalmol Vis Sci 45:2949-54. 2004
    ..To examine the cross-sectional relationship of the metabolic syndrome (hypertension, hyperglycemia, central obesity, and dyslipidemia) and retinal microvascular abnormalities in middle-aged men and women...
  60. doi Origin and turnover of ECM proteins from the inner limiting membrane and vitreous body
    W Halfter
    Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 14262, USA
    Eye (Lond) 22:1207-13. 2008
    ..Our data explain why ILM and VB do not regenerate after vitrectomy and ILM peeling...
  61. pmc Alterations in retinal microvascular geometry in young type 1 diabetes
    Muhammad Bayu Sasongko
    Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, Australia
    Diabetes Care 33:1331-6. 2010
    ..To describe retinal microvascular geometric parameters in young patients with type 1 diabetes...
  62. doi Effect of an inducer of BiP, a molecular chaperone, on endoplasmic reticulum (ER) stress-induced retinal cell death
    Yuta Inokuchi
    Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, Gifu, Japan
    Invest Ophthalmol Vis Sci 50:334-44. 2009
    ....
  63. ncbi RPE transplantation and its role in retinal disease
    Lyndon da Cruz
    Division of Cellular Therapy, Institute of Ophthalmology, 11 43 Bath Street, London EC1V 9EL, UK
    Prog Retin Eye Res 26:598-635. 2007
    ..in the Royal College of Surgeons (RCS) rat and in humans, photoreceptor dystrophies as well as complex retinal diseases such as atrophic and neovascular age-related macular degeneration (AMD)...
  64. ncbi Evaluation of image artifact produced by optical coherence tomography of retinal pathology
    Robin Ray
    Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina 27710, USA
    Am J Ophthalmol 139:18-29. 2005
    ..To determine the frequency and type of optical coherence tomography (OCT) fast macular thickness map (FMTM) scan artifacts, and whether these artifacts depend on patient diagnosis, demographics, and ocular therapy...
  65. doi Mitochondrial dysfunction in retinal diseases
    Megha Barot
    School of Pharmacy, University of Missouri Kansas City, Kansas City, MO 64108, USA
    Curr Eye Res 36:1069-77. 2011
    ..review highlights the role of mitochondrial dysfunction originating from oxidative stress in the etiology of retinal diseases including diabetic retinopathy, glaucoma and age-related macular degeneration (AMD)...
  66. ncbi The eye in hypertension
    Tien Yin Wong
    Centre for Eye Research Australia, University of Melbourne, Australia
    Lancet 369:425-35. 2007
    ..Recognition of the ocular effects of blood pressure could allow physicians to better manage patients with hypertension, and to monitor its end-organ effects...
  67. ncbi RPE lipofuscin and its role in retinal pathobiology
    Janet R Sparrow
    Department of Ophthalmology, Columbia University, 630 W 168th Street, New York, NY 10032, USA
    Exp Eye Res 80:595-606. 2005
    ..Since recent findings with respect to the origin, composition and adverse effects of RPE lipofuscin have informed our view of this material, the goal of this article is to review our current understanding of these issues...
  68. ncbi Retinal angiogenesis in development and disease
    Ray F Gariano
    Department of Ophthalmology, A 157, 300 Pasteur Drive, Stanford University School of Medicine, Palo Alto, California 94305, USA
    Nature 438:960-6. 2005
    ..The retina and its clinical disorders have a pivotal role in angiogenesis research and provide model systems in which to investigate neurovascular relationships and angiogenic diseases...
  69. pmc Spare the rod and spoil the eye
    G B Arden
    Henry Wellcome Laboratories, Applied Vision Research Centre, Department of Optometry and Visual Science, City University, Northampton Square, London EC1V 0HB, UK
    Br J Ophthalmol 89:764-9. 2005
    ....
  70. pmc Memantine blocks mitochondrial OPA1 and cytochrome c release and subsequent apoptotic cell death in glaucomatous retina
    Won Kyu Ju
    Hamilton Glaucoma Center, University of California San Diego, La Jolla, California 92037, USA
    Invest Ophthalmol Vis Sci 50:707-16. 2009
    ....
  71. doi Retinal inner nuclear layer microcystic changes in optic nerve atrophy: a novel spectral-domain OCT finding
    Benjamin Wolff
    Rothschild Ophthalmologic Foundation, Paris, France and Centre Ophtalmologique Rabelais, Lyon, France
    Retina 33:2133-8. 2013
    ..Optic atrophy constitutes the final stage in the evolution of optic neuropathy. The aim of this study was to describe the presence of macular microcystic changes or pseudocysts in patients with advanced optic atrophy...
  72. ncbi Metabolic effects of hypothermia and its neuroprotective effects on the recovery of metabolic and electrophysiological function in the ischemic retina in vitro
    Alfredo Quinones-Hinojosa
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
    Neurosurgery 52:1178-86; discussion 1186-7. 2003
    ..We describe experiments using hypothermia in the rabbit retina in vitro that show a correlation between hypothermia-induced reductions in energy usage and neuroprotection...
  73. doi Pleiotropic effects of YC-1 selectively inhibit pathological retinal neovascularization and promote physiological revascularization in a mouse model of oxygen-induced retinopathy
    M DeNiro
    Research Department, King Khaled Eye Specialist Hospital, Aruba Street, P O Box 7191, Riyadh 11462, Kingdom of Saudi Arabia
    Mol Pharmacol 77:348-67. 2010
    ..The pleiotropic effects of YC-1 allude to its possible use as a promising therapeutic iNOS inhibitor candidate for the treatment of retinal neovascularization...
  74. ncbi Slowly progressive cancer-associated retinopathy
    Wataru Saito
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Nishi 7 chome, Kita 15 jou, Kita ku, Sapporo 060 8638, Japan
    Arch Ophthalmol 125:1431-3. 2007
  75. pmc Translating induced pluripotent stem cells from bench to bedside: application to retinal diseases
    Alona O Cramer
    Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neuroscience, NIHR Biomedical Research Centre, University of Oxford, Oxford OX3 9DU, UK
    Curr Gene Ther 13:139-51. 2013
    ....
  76. doi Intravitreal triamcinolone
    Yong Tao
    Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht Karls University, Heidelberg, Germany
    Ophthalmologica 225:1-20. 2011
    ..to provide an update on the intravitreal use of triamcinolone acetonide...
  77. doi Rates and predictors of hydroxychloroquine retinal toxicity in patients with rheumatoid arthritis and systemic lupus erythematosus
    Frederick Wolfe
    National Data Bank for Rheumatic Diseases and University of Kansas School of Medicine, Wichita, KS 67214, USA
    Arthritis Care Res (Hoboken) 62:775-84. 2010
    ..We have studied the largest unselected series of patients to date to evaluate the risk of toxicity and the relevance of purported risk factors...
  78. doi Comparison of screening procedures in hydroxychloroquine toxicity
    Michael F Marmor
    Department of Ophthalmology, Stanford University School of Medicine, Byers Eye Institute at Stanford, 2452 Watson Ct, Palo Alto, CA 94303 5353, USA
    Arch Ophthalmol 130:461-9. 2012
    ..To compare different screening procedures for hydroxychloroquine sulfate (Plaquenil) toxicity at different stages of damage...
  79. doi Detection and monitoring of sickle cell retinopathy using ultra wide-field color photography and fluorescein angiography
    Minhee Cho
    Department of Ophthalmology, Weill Cornell Medical College, New York, New York 10021, USA
    Retina 31:738-47. 2011
    ..In this study, we demonstrate the use of wide-field photography and fluorescein angiography to visualize the peripheral vascular changes and to identify patients with risk factors for developing proliferative sickle cell retinopathy...
  80. pmc Retinal vessel diameters and risk of hypertension: the Multiethnic Study of Atherosclerosis
    Ryo Kawasaki
    Department of Ophthalmology, Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, Australia
    J Hypertens 27:2386-93. 2009
    ..To describe the prospective relationship of retinal vessel diameters with risk of hypertension in a multiethnic population-based cohort...
  81. doi Transcriptional code and disease map for adult retinal cell types
    Sandra Siegert
    Neural Circuit Laboratories, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    Nat Neurosci 15:487-95, S1-2. 2012
    ....
  82. pmc Astroglial NF-κB mediates oxidative stress by regulation of NADPH oxidase in a model of retinal ischemia reperfusion injury
    David J Barakat
    Department of Molecular, Cell and Developmental Biology, University of Miami Miller School of Medicine, Miami, Florida, USA
    J Neurochem 120:586-97. 2012
    ..Collectively, our results suggest that astroglial NF-κB-regulated PHOX activity is a crucial toxicity pathway in the pathogenesis of retinal IR injury...
  83. ncbi Gene deletion and pharmacological inhibition of aldose reductase protect against retinal ischemic injury
    Alvin K H Cheung
    Department of Anatomy, The University of Hong Kong, Pokfulam Road, Hong Kong, China
    Exp Eye Res 85:608-16. 2007
    ..Therefore, AR inhibition should be considered for the treatment of retinal ischemic injury often observed in diabetic patients...
  84. doi Microplasmin intravitreal administration in patients with vitreomacular traction scheduled for vitrectomy: the MIVI I trial
    Marc D de Smet
    Department of Ophthalmology, ZNA Middelheim Campus, Antwerp, Belgium
    Ophthalmology 116:1349-55, 1355.e1-2. 2009
    ..To evaluate the safety and preliminary efficacy of 4 doses and several exposure times of intravitreal microplasmin given before pars plana vitrectomy for vitreomacular traction maculopathy...
  85. doi Surgical outcomes of epiretinal membranes associated with combined hamartoma of the retina and retinal pigment epithelium
    Aaron D Cohn
    Beaumont Eye Institute, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    Retina 29:825-30. 2009
    ....
  86. pmc Retinal arteriolar caliber and urine albumin excretion: the Multi-Ethnic Study of Atherosclerosis
    Stella Awua-Larbi
    Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Nephrol Dial Transplant 26:3523-8. 2011
    ..Changes in retinal microvascular caliber, which occur prior to onset of retinopathy, may indicate presence of kidney damage...
  87. ncbi Transconjunctival sutureless 23-gauge vitrectomy
    Claus Eckardt
    Department of Ophthalmology, Staedtische Kliniken Frankfurt am Main Hoechst, Frankfurt, Germany
    Retina 25:208-11. 2005
  88. pmc An atypical form of Bietti crystalline dystrophy
    Settimio Rossi
    Department of Ophthalmology, Second University of Naples, Napoli, Italy
    Ophthalmic Genet 32:118-21. 2011
    ..To describe clinical and functional features of a patient with Bietti crystalline dystrophy and atypical electroretinogram responses...
  89. pmc A selective inhibitor of drp1, mdivi-1, increases retinal ganglion cell survival in acute ischemic mouse retina
    Sang Woo Park
    Sophie and Arthur Brody Optic Nerve Laboratory, Hamilton Glaucoma Center, University of California San Diego, La Jolla, California 92037, USA
    Invest Ophthalmol Vis Sci 52:2837-43. 2011
    ....
  90. pmc Dietary hyperglycemia, glycemic index and metabolic retinal diseases
    Chung Jung Chiu
    Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Department of Ophthalmology, School of Medicine, Tufts University, 711 Washington Street, Boston, MA 02111, United States
    Prog Retin Eye Res 30:18-53. 2011
    ..In this context, these diseases can be considered as metabolic retinal diseases. Molecular theories that explain hyperglycemic pathogenesis involve a mitochondria-associated pathway and ..
  91. doi Effects of ischemia-reperfusion on physiological properties of Müller glial cells in the porcine retina
    Antje Wurm
    Paul Flechsig Institut für Hirnforschung, Universitat Leipzig, Jahnallee 59, 04109 Leipzig, Germany
    Invest Ophthalmol Vis Sci 52:3360-7. 2011
    ..A viable animal model for human ischemic events should display similarities in eye size and retinal blood supply. Therefore, pigs were used in this investigation of physiological alterations in Müller cells after ischemia-reperfusion...
  92. pmc Short communication: PPAR gamma mediates a direct antiangiogenic effect of omega 3-PUFAs in proliferative retinopathy
    Andreas Stahl
    Department of Ophthalmology, Harvard Medical School, Children s Hospital, Boston, Mass 02115, USA
    Circ Res 107:495-500. 2010
    ..Omega3 long-chain polyunsaturated fatty acids (omega3-PUFAs) are powerful modulators of angiogenesis. However, little is known about the mechanisms governing omega3-PUFA-dependent attenuation of angiogenesis...
  93. pmc Neuroglobin protection in retinal ischemia
    Anita S Y Chan
    Doheny Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 53:704-11. 2012
    ..To explore the role of Ngb in retinal neuroprotection during ischemia reperfusion (IR), the authors examined the effect of Ngb overexpression in the retina in vivo by using Ngb-transgenic (Ngb-Tg) mice...
  94. pmc Identification of autoantibodies against TRPM1 in patients with paraneoplastic retinopathy associated with ON bipolar cell dysfunction
    Mineo Kondo
    Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    PLoS ONE 6:e19911. 2011
    ..The purpose of the current study is to investigate whether there are autoantibodies against TRPM1 in the sera of PR patients exhibiting ON bipolar cell dysfunction...
  95. doi Protective effects of catalase on retinal ischemia/reperfusion injury in rats
    Baihua Chen
    Department of Ophthalmology, Second Xiangya Hospital, Central South University, 139 Renming Middle Road, Changsha Hunan Province 410011, PR China
    Exp Eye Res 93:599-606. 2011
    ....
  96. ncbi Surgical management of epiretinal membrane in combined hamartomas of the retina and retinal pigment epithelium
    Xiao Zhang
    Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
    Retina 30:305-9. 2010
    ..The purpose of this study was to evaluate the surgical outcome of combined hamartomas of the retina and retinal pigment epithelium in five patients...
  97. pmc 15-year cumulative incidence and associated risk factors for retinopathy in nondiabetic persons
    Ronald Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, 53726, USA
    Arch Ophthalmol 128:1568-75. 2010
    ..To investigate the relationship of systemic factors to the 15-year cumulative incidence of retinopathy in nondiabetic persons in the Beaver Dam Eye Study...
  98. ncbi Optical coherence tomographic findings of combined hamartoma of the retina and retinal pigment epithelium in 11 patients
    Carol L Shields
    Ocular Oncology Service, Wills Eye Hospital, 840 Walnut St, Philadelphia, PA 19107, USA
    Arch Ophthalmol 123:1746-50. 2005
  99. ncbi PIII and derived PII analysis in a patient with retinal dysfunction with supernormal scotopic ERG
    Naoyuki Tanimoto
    Division of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Niigata University, 1 757, Asahimachi, Niigata, 951 8510, Japan
    Doc Ophthalmol 110:219-26. 2005
    ..To present electroretinographic (ERG) findings in a patient with retinal dysfunction with supernormal scotopic ERG, and to analyze rod and cone PIII components and rod inner nuclear layer (derived PII) responses...
  100. pmc Repeatability of in vivo parafoveal cone density and spacing measurements
    Robert Garrioch
    Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Optom Vis Sci 89:632-43. 2012
    ..To assess the repeatability and measurement error associated with cone density and nearest neighbor distance (NND) estimates in images of the parafoveal cone mosaic obtained with an adaptive optics scanning light ophthalmoscope (AOSLO)...
  101. pmc The value of measurement of macular carotenoid pigment optical densities and distributions in age-related macular degeneration and other retinal disorders
    Paul S Bernstein
    Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT, USA
    Vision Res 50:716-28. 2010
    ....

Research Grants70

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..Title: NEI Intramural Biorepository for Retinal Diseases Number: 12-EI-0042 Background: - To understand diseases of the retina and the eye, information is needed ..
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..Title: NEI Intramural Biorepository for Retinal Diseases Number: 12-EI-0042 Background: - To understand diseases of the retina and the eye, information is needed ..
  3. Genetic Studies of Optic Atrophy
    Taosheng Huang; Fiscal Year: 2012
    ..Many degenerative retinal diseases share similar clinical features and therefore, the data from this study may be extended to those diseases...
  4. Ceramide Metabolism and Photoreceptor Homeostasis
    Usha R Acharya; Fiscal Year: 2013
    ..model to understand normal pathways in the visual process and to pinpoint mutated genes that can lead to retinal diseases due to similarities between fly and human vision and because mechanisms that disrupt sight in flies also lead ..
  5. Prevention of Inherited Retinal Diseases by Therapeutic Rare Earth Nanoparticles
    JAMES FRANCIS MCGINNIS; Fiscal Year: 2010
    ..Antioxidants and over-expression of antioxidant enzymes have been shown to inhibit the progression of many retinal diseases. Inorganic cerium oxide nanoparticles (nanoceria) are antioxidants which mimic the activities of catalase and ..
  6. New Molecular and Cellular Mechanisms of Glaucoma
    Andrei Surguchov; Fiscal Year: 2013
    ..Since defects in MMP-9 control play an important role in glaucoma and some retinal diseases, the results received will provide essential insight into understanding the mechanisms and developing ..
  7. Cyr61/CCN1-Induced Angiogenesis and Vasculogenesis in the Retina
    Brahim Chaqour; Fiscal Year: 2010
    ..of our studies will determine how specific portions of such extracellular compound can be used/modified to allow the formation of normally functioning retinal blood vessels and improve the pharmacotherapy of several retinal diseases.
  8. CCR3: a molecular marker for neovascular AMD
    Jayakrishna Ambati; Fiscal Year: 2010
    ..As such, this proposal is perfectly aligned with the 5-year program goals of the NEI's Retinal Diseases strategic plan...
  9. MECHANISMS OF RETINAL VASCULAR PERMEABILITY IN DIABETES
    DAVID ANTONETTI; Fiscal Year: 2013
    ..inhibitors may provide an effective means to control vascular permeability in diabetic retinopathy and other retinal diseases involving VEGF and inflammatory cytokines...
  10. Genetic Control of Axial Patterning in Drosophila Eye
    Amit Singh; Fiscal Year: 2010
    ..study will also contribute to the understanding of mammalian eye development and etiology of early childhood retinal diseases. PUBLIC HEALTH RELEVANCE: Axial patterning, a fundamental process of organogenesis in multi-cellular ..
  11. Genetically testing interactions of ER and oxidative stresses in retinal disease
    Douglas Gould; Fiscal Year: 2013
    ..mechanism(s) that lead from mutation to retinopathy will identify pathways that underlie AMD and/or other retinal diseases. Mutant COL4A1 is misfolded, and secretion is impaired, leading to intracellular accumulation...
  12. Vision Sciences Training Grant
    Carol A Mason; Fiscal Year: 2013
    ..the mentors and trainees matches the goals in NEI's long-standing plan for eye and vision research for retinal diseases, cornea, and lens and cataract programs, as well as the strabismus, amblyopia and visual processing...
  13. Serotonin Receptor Modulation of Neurotrophic Factors in the Retina
    Mark E Pennesi; Fiscal Year: 2013
    ..positive findings from this study could rapidly translate to human clinical trials for currently incurable retinal diseases. The hypothesis of this proposal is that administration of SSRIs or serotonin receptor modulators (SRMs) will ..
  14. Regulated Transgene Expression in the Retina
    James M Wilson; Fiscal Year: 2010
    ..of the ARGENT system for AMD will provide a platform of gene therapy that can be applied to a broad array of retinal diseases. Funding of this application will create 2 new jobs...
  15. Computational Design of Small Molecule Drugs Inhibiting the Zinc Finger Transcrip
    David Sherris; Fiscal Year: 2010
    ..off pathological protein manufacturing capability at its source in pathological conditions such as cancer and retinal diseases of neovasculature...
  16. Establishing a neuroprotection model in the nonhuman primate to support translati
    MATTHEW SWAN LAWRENCE; Fiscal Year: 2013
    Optic nerve and retinal diseases profoundly impact quality of life and overall health care burden...
  17. Mesenchymal Stem Cells for Treatment of Retinal Diseases
    Martin L Katz; Fiscal Year: 2011
    ..vehicles for long-term, sustained delivery of therapeutic agents to eye tissues of people with a variety of retinal diseases. This approach to therapy will be tested be evaluating the ability of intraocular implantation of ..
  18. Novel Adeno-Associated Viral Therapy for X-linked Retinitis Pigmentosa
    James M Wilson; Fiscal Year: 2010
    ..a novel "first-in-class" therapy that will provide a platform for treating additional forms of RP and other retinal diseases. PUBLIC HEALTH RELEVANCE: Retinitis pigmentosa is the most common inherited form of blindness, with an ..
  19. Regulation of UV-induced apoptosis
    Heinrich Jasper; Fiscal Year: 2013
    ..macrophages (or microglia) play an important role in promoting homeostasis of the retina, influencing retinal diseases, including age-related macular degeneration...
  20. Progressive impact of diabetes on retinal neuroprotection by ?-crystallins
    Patrice E Fort; Fiscal Year: 2013
    ..of ?-crystallins during diabetes will lead to strategies to enhance retinal cell viability in chronic retinal diseases such as diabetic retinopathy, uveitis, and age-related macular degeneration...
  21. Neuroprotective agents for retinal diseases
    CHRIS LINDSEY; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Mitochondrial dysfunction is a major contributor to retinal diseases. At this time, there are no effective therapies that can restore mitochondrial function to promote ..
  22. Circadian Clock Function in the Mammalian Retina
    Christophe P Ribelayga; Fiscal Year: 2013
    ..circadian regulation of retinal physiology may contribute to photoreceptor cell death in some degenerative retinal diseases. Therefore, establishing the basis of circadian rhythmicity in the retina is essential for our understanding ..
  23. MOLECULAR STUDIES OF RETINAL DEGENERATION IN DROSOPHILA
    Nansi J Colley; Fiscal Year: 2013
    ..provided by applicant): Our long-term objective is to understand the molecular genetics of hereditary human retinal diseases, such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD)...
  24. RPE MESSENGERS, TRANSCRIPTION AND PHOTORECEPTOR RENEWAL
    NICOLAS GUILLERMO BAZAN; Fiscal Year: 2013
    ..of photoreceptors and RPE cells, which will translate to new understandings regarding ocular health and retinal diseases. We will thus contribute to apply this knowledge to the prevention, repair or amelioration of retinal ..
  25. Survival and growth-promotion mechanisms of the GDNF family ligands (GFLs)
    BRIAN ANTHONY PIERCHALA; Fiscal Year: 2012
    ..treatment of neurodegenerative diseases such as Parkinson's disease, Huntington's disease, ALS, and retinal diseases, and for injuries of the nervous system such as spinal cord injury (SCI) and stroke...
  26. Investigation of autoimmune anti-retinal antibodies in diabetes
    John R Heckenlively; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Anti-retinal antibodies (ARAs) definitely have an effect on many retinal diseases. We have consistently found that elevated ARAs exacerbate the disease or cause additional complications that regress ..
  27. Achromatopsia - Disease Mechanisms and Cone-Directed Gene Therapy
    Andras Komaromy; Fiscal Year: 2013
    ..As such, it is of utmost importance to target cones when designing therapeutic treatment for retinal diseases such as achromatopsia, cone dystrophies, and cone-rod dystrophies that primarily affect cones...
  28. High Performance Multimodal Adaptive Optics Retinal Imaging
    R Daniel Ferguson; Fiscal Year: 2011
    ..completed a Phase I program to develop a multimodal adaptive optics (AO) retinal imager for diagnosis of retinal diseases, including glaucoma, diabetic retinopathy (DR), age-related macular degeneration (AMD), and retinitis ..
  29. Asia-ARVO Travel Awards and Symposium
    Sally S Atherton; Fiscal Year: 2010
    ..by the National Eye Institute (NEI) of the United States National Institutes of Health (NIH), including: retinal diseases;corneal diseases;lens and cataract;glaucoma and optic neuropathies;strabismus, amblyopia, and visual ..
  30. TRP channel expression and function in ON-bipolar cells
    Robert M Duvoisin; Fiscal Year: 2012
    Project Summary/Abstract Congenital stationary night blindness (CSNB) is a group of non-progressive retinal diseases characterized by impaired scotopic vision. Mutations in a number of genes have been shown to be associated with CSNB...
  31. Non-Viral Gene Therapy for Retinal Degeneration
    Rajendra Kumar-Singh; Fiscal Year: 2013
    ..gene therapy clinical trials have remarkably demonstrated that gene therapy is a valid approach to treat retinal diseases. Each of these clinical trials and almost every preclinical gene therapy study thus far have utilized viruses ..
  32. Role of Nrf2 in retinal vascularization and ROP
    Elia J Duh; Fiscal Year: 2013
    ..Indeed, promotion of revascularization is highly desirable in a variety of retinal diseases, particularly the ischemi retinopathies...
  33. Structure &Function of Ganglion-Cell Photoreceptors Contributing to Form Vision
    MAUREEN ESTRELLITA ESTEVEZ; Fiscal Year: 2013
    ..addition, this work may be shed new light on residual visual capacities in ocularly blind patients with outer retinal diseases, such as retinitis pigmentosa, age-related macular degeneration or Leber's congenital amaurosis, in ..
  34. RDS mutations: Gene therapy for ADRP, macular degeneration and pattern dystrophy
    Alfred S Lewin; Fiscal Year: 2010
    ..of other investigators suggest that these experiments will prove fruitful and will lead to a treatment for retinal diseases caused by RDS mutations...
  35. Defining the molecular mechanisms underlying human RPE plasticity
    Sally Temple; Fiscal Year: 2013
    ..Disruption of RPE stability is known to occur in several important retinal diseases such as epiretinal membrane formation, macular degeneration and phthsis bulbii, and understanding this ..
  36. Emp2: Potential Control Of Pathology In Retinal Pigment Epithelium
    Lynn Gordon; Fiscal Year: 2009
    ..2) Evaluate the association of EMP2 and its signaling pathways in human PVR and other scarring retinal diseases. The underlying and testable hypothesis of this aim is that EMP2 and its associated signaling pathways are ..
  37. Pharmacological Treatment of Retinal Diseases
    KRZYSZTOF NMI PALCZEWSKI; Fiscal Year: 2013
    ..partnership will employ its diverse scientific expertise to characterize and test potential therapies for retinal diseases in animal models by using a combination of cutting-edge physiological, chemical, analytical and imaging ..
  38. Mechanism of photoreceptor cell degeneration in animal models of retinal diseases
    Muna I Naash; Fiscal Year: 2012
    ..OSs) fail to develop, and over 80 different Rds mutations have been shown to cause several inherited retinal diseases. The goals of this program are: 1) to uncover the mechanisms underlying the differential behavior of Rds in ..
  39. Prevention of photoreceptor cell death with intravitreal Fas-receptor antagonist
    Jeffrey A Jamison; Fiscal Year: 2012
    ..provided by applicant): Death of photoreceptor cells is a consequence of many acute as well as chronic retinal diseases which lead to severe vision loss in patients...
  40. The Mechanism of the Outer Blood-Retina Barrier Breakdown
    Zsolt Ablonczy; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): A common element in several retinal diseases is the accumulation of fluid within the extracellular space of the neurosensory retina...
  41. Stimulation Thresholds of Ganglion Cells in the Degenerate Retina
    Ralph J Jensen; Fiscal Year: 2011
    ..and development of a retinal prosthesis to restore useful vision to blind veterans who have degenerative retinal diseases is a major goal of our Center at the VA Boston Healthcare System...
  42. Molecular Mechanisms of Retinal cGMP-Activated Ion Channels
    Michael D Varnum; Fiscal Year: 2012
    ..is to understand the mechanisms controlling the activity of these channels and the pathophysiology of retinal diseases associated with CNG channel mutations...
  43. Retinal Degeneration Conference
    Robert E Anderson; Fiscal Year: 2010
    ..a common interest among basic and clinical scientists in understanding the fundamental mechanisms underlying retinal diseases. This meeting, which has been held biennially since 1984, has been responsible for fostering many of the ..
  44. Transscleral Drug Delivery for Retinal Disorders
    HENRY FRANCIS EDELHAUSER; Fiscal Year: 2010
    ..The drugs to be tested are known to affect retinal diseases in basic science experiments, pre-clinical studies, or clinical studies...
  45. The Role of Vitamin D in Retinal Diseases in Aging
    AMY ELIZABETH MILLEN; Fiscal Year: 2013
    ..The long-term goal of the proposed research is to better understand the role of vitamin D status in retinal diseases highly prevalent in aging individuals...
  46. Rescue of GUCY1*B Phenotype Using Somatic Gene Therapy
    SUSAN LYNN SEMPLE-ROWLAND; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The goal of our research program is to develop therapies for inherited retinal diseases that support long-term photoreceptor function and survival...
  47. DEVELOPMENT OF SYNAPTIC PATHWAYS IN RETINA
    Ning Tian; Fiscal Year: 2013
    ..for the understanding of the molecular and synaptic mechanisms essential for the pathogenesis in degenerative retinal diseases. The long-term goal of this study is to identify the mechanism that regulates RGC dendritic remodeling under ..
  48. Dynamic Usage of Network Motifs in Retinal Development and Diseases
    Jiang Qian; Fiscal Year: 2012
    ..Perturbation of the retinal regulatory network can lead to various retinal diseases. High-throughput technologies (e.g...
  49. Genetic Modifiers of Photoreceptor Development and Maintenance
    Neena B Haider; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Retinal diseases are debilitating disorders that affect millions of individuals worldwide and can often lead to complete ..
  50. Molecular Genetics of Age-Dependent Retinal Degeneration
    Akihiro Ikeda; Fiscal Year: 2013
    ..Our long-term goal is to understand the molecular mechanisms causing retinal defects associated with human retinal diseases and aging...
  51. Disposable Instrument for Broader Patient Access to Vision Restoration Therapy
    Robert B Aramant; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Retinal diseases such as age-related macular degeneration (AMD), retinal dystrophies, and retinitis pigmentosa (RP) affect millions of Americans...
  52. RHODOPSIN TRAFFICKING AND PHOTORECEPTOR MEMBRANE RENEWAL
    DUSANKA DANIELLE DERETIC; Fiscal Year: 2013
    ..by which mutations in genes that regulate rhodopsin trafficking and photoreceptor membrane renewal lead to retinal diseases. Mutations in rhodopsin that affect the C- terminal VxPx motif cause severe forms of autosomal dominant ..
  53. Transport processes in photoreceptors
    Yiannis Koutalos; Fiscal Year: 2012
    ..Defects in all-trans retinal removal have been implicated in a variety of retinal diseases, ranging from impaired dark adaptation to complete blindness...
  54. Role of toll-like receptor signaling in retinal ischemia
    Dmitry V Ivanov; Fiscal Year: 2013
    ..the events involved in ischemic neuronal injury can provide us with clinically effective treatments for many retinal diseases. Although the cause of this injury is multifactorial, increasing experimental evidence suggests an important ..
  55. Genetic polymorphisms in retinal detachment with proliferative vitreoretinopathy
    COLLEEN MARIE CEBULLA; Fiscal Year: 2013
    ..The knowledge gained on the genetic basis of RD-PVR may also lead to a better understanding of other blinding fibrotic retinal diseases such as macular degeneration, ROP, and proliferative diabetic retinopathy.
  56. Rhodopsins: from biosynthesis and degradation to unconventional functions
    Craig Montell; Fiscal Year: 2013
    ..Multiple retinal diseases also result from defects in the production and regeneration of the chromophore in the retinal pigment ..
  57. Clinical trials of gene therapy for Leber congenital amaurosis
    SAMUEL GREGORY JACOBSON; Fiscal Year: 2013
    ..and clarify expectations of gene therapy in this disease and lead to better approaches to other human genetic retinal diseases that are queuing up as future candidates for this type of therapy...
  58. REGULATION OF CYCLIC GMP SYNTHESIS IN PHOTORECEPTORS
    Alexander M Dizhoor; Fiscal Year: 2013
    ..protein-protein interactions in GCAP and RetGC result in the cyclase activation and inhibition or triggering retinal diseases. Seeking answers to the questions addressed in this proposal conforms to the NEI mission to "conduct research ..
  59. Vitreal delivery of novel AAV vectors for CNGA3 achromatopsia cone gene therapy
    Jijing Pang; Fiscal Year: 2013
    ..gene-based therapies following intravitreal (IV) injection will be clinically useful for a wide variety of retinal diseases with cne dysfunctions...
  60. Membrane-targeting calcium sensors in vision
    James B Ames; Fiscal Year: 2013
    ..4) at the rod synapse to understand the Ca2+-dependent regulatory mechanism of ion channels linked to retinal diseases.
  61. Epidemiology of Age-related Macular Degeneration and Other Retinal Diseases
    Ronald Klein; Fiscal Year: 2012
    ..Dam, Blue Mountains and Rotterdam) of European ancestry;and (4) examine the natural history of AMD and other retinal diseases (e.g...
  62. Applied Statistics to a Secondary Analysis of Public Repositories for Microarray
    Haiyan Huang; Fiscal Year: 2010
    ..Currently, over 200 genes were identified that cause retinal diseases. We will apply the developed methods to retinal microarray expression databases to identify novel genes and ..
  63. Induction of the blood-retinal barrier
    DAVID ANTONETTI; Fiscal Year: 2010
    ..of retinopathy of prematurity, diabetic retinopathy, age related macular degeneration and other retinal diseases. Further, pathological angiogenesis produces highly permeable vessels that lack a proper blood-retinal ..
  64. Genetic basis of cone opsin gene expression
    KAREN CARLETON; Fiscal Year: 2005
    ..Defective opsin genes lead to a variety of retinal diseases including retinitis pigmentosa, congenital night blindness, and color blindness...
  65. ISOLATION & CHARACTERIZATION OF HRG4, A NEW RETINAL GENE
    George Inana; Fiscal Year: 2003
    ..and studied in the investigator's laboratory in order to identify etiologies for hereditary blinding retinal diseases, to study how these genes cause disease, and to use this information to find the best treatment or cure for ..
  66. The mechanism of IMPDH1-mediated retinitis pigmentosa
    Lizbeth Hedstrom; Fiscal Year: 2007
    ..by applicant): The long-term goal of our research is to understand the molecular mechanisms of hereditary retinal diseases and lay the foundation for the rational development of treatment...
  67. Noninvsive Imaging of Chorio-retinal Oxygen Tension
    Mahnaz Shahidi; Fiscal Year: 2005
    ..tissue in health and disease has not been adequately studied, and the role of oxygen in the development of retinal diseases, and their associated vascular pathologies, is not well understood...
  68. Hign Performance MEMS Deformable Mirror for Adaptive Optics Retinal Imaging
    MICHAEL HELMBRECHT; Fiscal Year: 2009
    ..expertise from DM manufacturing to building AO retinal-imaging systems for daily use in studying retinal diseases at the cellular-level will drive a revolution in advanced imaging techniques...
  69. PHOTOTRANSDUCTION, AGING AND RETINAL DEGENERATION
    Melvin Simon; Fiscal Year: 2003
    ..A variety of age related, late onset retinal diseases are the result of apoptotic signaling and neural degeneration...
  70. Retina Implantation Instrument Kit
    Robert Aramant; Fiscal Year: 2007
    ..b>Retinal diseases such as macular degeneration, retinal dystrophies, and retinitis pigmentosa (RP) afflict more than 8...