myopia

Summary

Summary: A refractive error in which rays of light entering the EYE parallel to the optic axis are brought to a focus in front of the RETINA when accommodation (ACCOMMODATION, OCULAR) is relaxed. This results from an overly curved CORNEA or from the eyeball being too long from front to back. It is also called nearsightedness.

Top Publications

  1. ncbi Myopia
    Ian G Morgan
    ARC Centre of Excellence in Vision Science, Research School of Biology, College of Medicine, Biology and Environment, Australian National University, Canberra, Australia
    Lancet 379:1739-48. 2012
  2. ncbi Results of small incision lenticule extraction: All-in-one femtosecond laser refractive surgery
    Rupal Shah
    New Vision Laser Centers, Vadodara, Gujarat, India
    J Cataract Refract Surg 37:127-37. 2011
  3. pmc Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia
    Virginie J M Verhoeven
    Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands
    Nat Genet 45:314-8. 2013
  4. ncbi Small incision corneal refractive surgery using the small incision lenticule extraction (SMILE) procedure for the correction of myopia and myopic astigmatism: results of a 6 month prospective study
    Walter Sekundo
    Department of Ophthalmology, Philipps University of Marburg, Robert Koch Strasse 4, 35037 Marburg, Germany
    Br J Ophthalmol 95:335-9. 2011
  5. ncbi Worldwide prevalence and risk factors for myopia
    Chen Wei Pan
    Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Ophthalmic Physiol Opt 32:3-16. 2012
  6. pmc A genome-wide association study identifies a susceptibility locus for refractive errors and myopia at 15q14
    Abbas M Solouki
    Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands
    Nat Genet 42:897-901. 2010
  7. ncbi High myopia and glaucoma susceptibility the Beijing Eye Study
    Liang Xu
    Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China
    Ophthalmology 114:216-20. 2007
  8. pmc Genetic variants on chromosome 1q41 influence ocular axial length and high myopia
    Qiao Fan
    Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore
    PLoS Genet 8:e1002753. 2012
  9. pmc Genome-wide analysis points to roles for extracellular matrix remodeling, the visual cycle, and neuronal development in myopia
    Amy K Kiefer
    23andMe, Mountain View, California, United States of America
    PLoS Genet 9:e1003299. 2013
  10. pmc Large scale international replication and meta-analysis study confirms association of the 15q14 locus with myopia. The CREAM consortium
    Virginie J M Verhoeven
    Department of Ophthalmology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    Hum Genet 131:1467-80. 2012

Detail Information

Publications361 found, 100 shown here

  1. ncbi Myopia
    Ian G Morgan
    ARC Centre of Excellence in Vision Science, Research School of Biology, College of Medicine, Biology and Environment, Australian National University, Canberra, Australia
    Lancet 379:1739-48. 2012
    b>Myopia has emerged as a major health issue in east Asia, because of its increasingly high prevalence in the past few decades (now 80-90% in school-leavers), and because of the sight-threatening pathologies associated with high myopia, ..
  2. ncbi Results of small incision lenticule extraction: All-in-one femtosecond laser refractive surgery
    Rupal Shah
    New Vision Laser Centers, Vadodara, Gujarat, India
    J Cataract Refract Surg 37:127-37. 2011
    ..To report the clinical results of small incision lenticule extraction to correct refractive errors using a femtosecond laser to refine the femtosecond lenticule extraction technique...
  3. pmc Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia
    Virginie J M Verhoeven
    Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands
    Nat Genet 45:314-8. 2013
    Refractive error is the most common eye disorder worldwide and is a prominent cause of blindness. Myopia affects over 30% of Western populations and up to 80% of Asians...
  4. ncbi Small incision corneal refractive surgery using the small incision lenticule extraction (SMILE) procedure for the correction of myopia and myopic astigmatism: results of a 6 month prospective study
    Walter Sekundo
    Department of Ophthalmology, Philipps University of Marburg, Robert Koch Strasse 4, 35037 Marburg, Germany
    Br J Ophthalmol 95:335-9. 2011
    ..This 6 month prospective multi-centre study evaluated the feasibility of performing myopic femtosecond lenticule extraction (FLEx) through a small incision using the small incision lenticule extraction (SMILE) procedure...
  5. ncbi Worldwide prevalence and risk factors for myopia
    Chen Wei Pan
    Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Ophthalmic Physiol Opt 32:3-16. 2012
    b>Myopia, the most common type of refractive error, is a complex trait including both genetic and environmental factors. Numerous studies have tried to elucidate the aetiology of myopia...
  6. pmc A genome-wide association study identifies a susceptibility locus for refractive errors and myopia at 15q14
    Abbas M Solouki
    Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands
    Nat Genet 42:897-901. 2010
    ..We identified a significant association at chromosome 15q14 (rs634990, P = 2.21 × 10⁻¹⁴). The odds ratio of myopia compared to hyperopia for the minor allele (minor allele frequency = 0.47) was 1.41 (95% CI 1.16-1...
  7. ncbi High myopia and glaucoma susceptibility the Beijing Eye Study
    Liang Xu
    Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China
    Ophthalmology 114:216-20. 2007
    To evaluate whether marked myopia, compared with moderate myopia and low myopia, is associated with a higher prevalence of glaucomatous optic nerve damage.
  8. pmc Genetic variants on chromosome 1q41 influence ocular axial length and high myopia
    Qiao Fan
    Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore
    PLoS Genet 8:e1002753. 2012
    As one of the leading causes of visual impairment and blindness, myopia poses a significant public health burden in Asia. The primary determinant of myopia is an elongated ocular axial length (AL)...
  9. pmc Genome-wide analysis points to roles for extracellular matrix remodeling, the visual cycle, and neuronal development in myopia
    Amy K Kiefer
    23andMe, Mountain View, California, United States of America
    PLoS Genet 9:e1003299. 2013
    b>Myopia, or nearsightedness, is the most common eye disorder, resulting primarily from excess elongation of the eye. The etiology of myopia, although known to be complex, is poorly understood...
  10. pmc Large scale international replication and meta-analysis study confirms association of the 15q14 locus with myopia. The CREAM consortium
    Virginie J M Verhoeven
    Department of Ophthalmology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    Hum Genet 131:1467-80. 2012
    b>Myopia is a complex genetic disorder and a common cause of visual impairment among working age adults...
  11. pmc A genome-wide association study for myopia and refractive error identifies a susceptibility locus at 15q25
    Pirro G Hysi
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London, UK
    Nat Genet 42:902-5. 2010
    b>Myopia and hyperopia are at opposite ends of the continuum of refraction, the measure of the eye's ability to focus light, which is an important cause of visual impairment (when aberrant) and is a highly heritable trait...
  12. ncbi The sclera and myopia
    Jody A Summers Rada
    Department of Cell Biology, University of Oklahoma Health Science Center, 940 Stanton L Young Boulevard, BMSB, Room 553, Oklahoma City, 73104, USA
    Exp Eye Res 82:185-200. 2006
    b>Myopia is a very common ocular problem, affecting perhaps one billion people worldwide. Most myopia is produced by lengthening of the vitreous chamber of the ocular globe...
  13. ncbi Myopia and associated pathological complications
    Seang Mei Saw
    Department of Community, Occupational and Family Medicine, National University of Singapore, 16 Medical Drive, Singapore 117597
    Ophthalmic Physiol Opt 25:381-91. 2005
    Besides the direct economic and social burden of myopia, associated ocular complications may lead to substantial visual loss...
  14. ncbi Outdoor activity and myopia in Singapore teenage children
    M Dirani
    Singapore Eye Research Institute, and Department of Community, Occupational and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, MD3, 16 Medical Drive, Singapore 117597
    Br J Ophthalmol 93:997-1000. 2009
    To investigate the relationship of outdoor activities and myopia in Singapore teenage children.
  15. pmc Time outdoors and physical activity as predictors of incident myopia in childhood: a prospective cohort study
    Jeremy A Guggenheim
    School of Optometry and Vision Sciences, Cardiff University, Cardiff, Wales, United Kingdom
    Invest Ophthalmol Vis Sci 53:2856-65. 2012
    Time spent in "sports/outdoor activity" has shown a negative association with incident myopia during childhood. We investigated the association of incident myopia with time spent outdoors and physical activity separately.
  16. ncbi Prevalence of myopia and its association with body stature and educational level in 19-year-old male conscripts in seoul, South Korea
    Su Kyung Jung
    Department of Ophthalmology and Visual Science, St Vincent s Hospital, College of Medicine, Catholic University of Korea, Suwon, Korea
    Invest Ophthalmol Vis Sci 53:5579-83. 2012
    ..To examine prevalence of refractive errors and its associated factors, such as body stature and educational level, among 19-year-old males in Seoul, Korea...
  17. ncbi Increased prevalence of myopia in the United States between 1971-1972 and 1999-2004
    Susan Vitale
    Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, 10 Center Dr, Room 10D45, Mail Stop 1863, Bethesda, MD 20892 1863, USA
    Arch Ophthalmol 127:1632-9. 2009
    To compare US population prevalence estimates for myopia in 1971-1972 and 1999-2004.
  18. pmc PAX6 haplotypes are associated with high myopia in Han chinese
    Bo Jiang
    Department of Ophthalmology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
    PLoS ONE 6:e19587. 2011
    The paired box 6 (PAX6) gene is considered as a master gene for eye development. Linkage of myopia to the PAX6 region on chromosome 11p13 was shown in several studies, but the results for association between myopia and PAX6 were ..
  19. ncbi Replication study supports CTNND2 as a susceptibility gene for high myopia
    Boyu Lu
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
    Invest Ophthalmol Vis Sci 52:8258-61. 2011
    The CTNND2 gene is located in the linkage interval of high myopia locus MYP16 and two single-nucleotide polymorphisms (SNPs; rs6885224 and rs12716080) in CTNND2 were recently shown to associate with high myopia...
  20. ncbi Association of 15q14 and 15q25 with high myopia in Japanese
    Hisako Hayashi
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Invest Ophthalmol Vis Sci 52:4853-8. 2011
    To investigate whether there are associations of genetic variations in chromosome 15q14 and 15q25, recently shown to confer risk of refractive error and myopia in Caucasians, with high myopia in Japanese.
  21. ncbi Outdoor activity reduces the prevalence of myopia in children
    Kathryn A Rose
    School of Applied Vision Sciences, Faculty of Health Sciences, University of Sydney, Sydney, Australia
    Ophthalmology 115:1279-85. 2008
    To assess the relationship of near, midworking distance, and outdoor activities with prevalence of myopia in school-aged children.
  22. ncbi The relationship between glaucoma and myopia: the Blue Mountains Eye Study
    P Mitchell
    Department of Ophthalmology, University of Sydney, Westmead Hospital, NSW, Australia
    Ophthalmology 106:2010-5. 1999
    To quantify the relationship between myopia and open-angle glaucoma, ocular hypertension (OH), and intraocular pressure (IOP) in a representative older population.
  23. ncbi First efficacy and safety study of femtosecond lenticule extraction for the correction of myopia: six-month results
    Walter Sekundo
    Department of Ophthalmology, Gutenberg University, Langenbeckstrasse 1, Mainz, Germany
    J Cataract Refract Surg 34:1513-20. 2008
    ..To prospectively study the feasibility of femtosecond lenticule extraction (FLE), a new method of refractive correction...
  24. ncbi Femtosecond laser versus mechanical keratome LASIK for myopia
    Robert Montes-Mico
    Optics Department, Faculty of Physics, University of Valencia, Valencia, Spain
    Ophthalmology 114:62-8. 2007
    To assess efficacy, safety, predictability, stability, and changes in corneal higher-order aberrations (CHOAs) and contrast sensitivity (CS) after a femtosecond laser for LASIK and standard LASIK for myopia.
  25. ncbi First clinical results with the femtosecond neodynium-glass laser in refractive surgery
    Imola Ratkay-Traub
    Focus Medical Eye Micro surgery and Laser Center, Budapest, Hungary
    J Refract Surg 19:94-103. 2003
    ..cutting procedures: creation of a corneal flap for laser in situ keratomileusis (LASIK), tunnel and entry cut for intracorneal ring, corneal flap and removable lens for keratomileusis, and intrastromal ablation for myopia and hyperopia.
  26. ncbi Femtosecond lenticule extraction (FLEx): clinical results, interface evaluation, and intraocular pressure variation
    Marcus Ang
    Singapore National Eye Centre, Singapore
    Invest Ophthalmol Vis Sci 53:1414-21. 2012
    ..To characterize the clinical profile of femtosecond lenticule extraction (FLEx) correlated with ultrastructural analysis of the corneal interface and in vivo real-time intraocular pressure (IOP)...
  27. ncbi Femtosecond lenticule extraction for the correction of myopia: preliminary 6-month results
    Marcus Blum
    Department of Ophthalmology, Helios Hospital Erfurt, Nordhäusser Str 74, 99089, Erfurt, Germany
    Graefes Arch Clin Exp Ophthalmol 248:1019-27. 2010
    ..To report the 6-month results of a new method of refractive correction, femtosecond lenticule extraction (FLEx), and the preliminary outcomes in the first 108 eyes...
  28. ncbi Prevalence and causes of low vision and blindness in a Japanese adult population: the Tajimi Study
    Aiko Iwase
    Department of Ophthalmology, Tajimi Municipal Hospital, Tajimi, Japan
    Ophthalmology 113:1354-62. 2006
    ..To determine the prevalence and causes of low vision and blindness in a Japanese adult population...
  29. pmc Exome sequencing identifies ZNF644 mutations in high myopia
    Yi Shi
    The Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Chengdu, Sichuan, China
    PLoS Genet 7:e1002084. 2011
    b>Myopia is the most common ocular disorder worldwide, and high myopia in particular is one of the leading causes of blindness. Genetic factors play a critical role in the development of myopia, especially high myopia...
  30. pmc Myopia genetics: a review of current research and emerging trends
    Dana M Hornbeak
    Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, USA
    Curr Opin Ophthalmol 20:356-62. 2009
    b>Myopia, or nearsightedness, is the most common human eye disorder in the world and is a significant global public health concern...
  31. ncbi Scleral remodeling during the development of and recovery from axial myopia in the tree shrew
    N A McBrien
    Department of Optometry and Vision Sciences, The University of Melbourne, Victoria, Australia
    Invest Ophthalmol Vis Sci 41:3713-9. 2000
    Recent investigations have suggested that scleral thinning in mammalian eyes with axial myopia is a consequence of the loss of scleral tissue, rather than the redistribution of existing tissue as the eye enlarges...
  32. ncbi Prevalence of myopia in Taiwanese schoolchildren: 1983 to 2000
    L L K Lin
    Department of Ophthalmology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Ann Acad Med Singapore 33:27-33. 2004
    To determine time trends in myopia over a 20-year period in Taiwan, we conducted 5 nationwide surveys pertaining to the ocular refraction of schoolchildren in 1983, 1986, 1990, 1995 and 2000.
  33. ncbi Phakic intraocular lens implantation for the correction of myopia: a report by the American Academy of Ophthalmology
    David Huang
    Ophthalmology 116:2244-58. 2009
    To review the published literature for evaluation of the safety and outcomes of phakic intraocular lens (pIOL) implantation for the correction of myopia and myopic astigmatism.
  34. pmc Effect of prophylactic and therapeutic mitomycin C on corneal apoptosis, cellular proliferation, haze, and long-term keratocyte density in rabbits
    Marcelo V Netto
    The Cole Eye Institute, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Refract Surg 22:562-74. 2006
    ..To determine the mechanism through which topical mitomycin C prevents and treats corneal haze after photorefractive keratectomy (PRK) and to examine the effects of dosage and duration of exposure...
  35. ncbi Prevalence of myopia in urban and rural children in mainland China
    Mingguang He
    Department of Preventive Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, People s Republic of China
    Optom Vis Sci 86:40-4. 2009
    It has been well recognized that myopia more likely affects East Asians, particularly the Japanese and Chinese population...
  36. pmc Genetic variants at 13q12.12 are associated with high myopia in the Han Chinese population
    Yi Shi
    The Sichuan Provincial Key Laboratory for Human Disease Gene Study and The Institute of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Chengdu, Sichuan 610072, China
    Am J Hum Genet 88:805-13. 2011
    High myopia, which is extremely prevalent in the Chinese population, is one of the leading causes of blindness in the world. Genetic factors play a critical role in the development of the condition...
  37. ncbi The role of the retinal pigment epithelium in eye growth regulation and myopia: a review
    Jodi Rymer
    School of Optometry, University of California Berkeley, 94720, USA
    Vis Neurosci 22:251-61. 2005
    b>Myopia is increasing in prevalence world-wide, nearing epidemic proportions in some populations. This has led to expanded research efforts to understand how ocular growth and refractive errors are regulated...
  38. ncbi Anterior chamber depth in relation to refractive status measured with the Orbscan II Topography System
    Tanja M Rabsilber
    Department of Ophthalmology, Ruprecht Karls University of Heidelberg, Heidelberg, Germany
    J Cataract Refract Surg 29:2115-21. 2003
    ....
  39. ncbi Comparison of higher order aberrations after LASIK and LASEK for myopia
    Colm McAlinden
    School of Biomedical Sciences, University of Ulster, Coleraine, United Kingdom
    J Refract Surg 26:45-51. 2010
    ..To compare the change in higher order aberrations (HOAs) after LASIK and laser epithelial keratomileusis (LASEK)...
  40. ncbi Sonic hedgehog expression and its role in form-deprivation myopia in mice
    Yi shan Qian
    Department of Ophthalmology, Eye, Ear, Nose, Throat Hospital, Fudan University, Shanghai Medical College, Shanghai
    Curr Eye Res 34:623-35. 2009
    To investigate whether sonic hedgehog (Shh) plays a role in postnatal eye development and the development of experimentally induced myopia.
  41. pmc Causes of visual impairment in people aged 75 years and older in Britain: an add-on study to the MRC Trial of Assessment and Management of Older People in the Community
    J R Evans
    Department of Epidemiology and International Eye Health, Institute of Ophthalmology, London, UK
    Br J Ophthalmol 88:365-70. 2004
    ..It is important to know the causes of visual impairment to develop health service and research priorities. The authors aimed to identify the causes of visual impairment in people aged 75 years and older in Britain...
  42. pmc Nature and nurture: the complex genetics of myopia and refractive error
    R Wojciechowski
    Statistical Genetics Section, Inherited Disease Branch, National Human Genome Research Institute NIH, 333 Cassell Drive, Baltimore, MD 21224, USA
    Clin Genet 79:301-20. 2011
    The refractive errors, myopia and hyperopia, are optical defects of the visual system that can cause blurred vision. Uncorrected refractive errors are the most common causes of visual impairment worldwide. It is estimated that 2...
  43. ncbi Collagen gene expression and the altered accumulation of scleral collagen during the development of high myopia
    Alex Gentle
    Department of Optometry and Vision Sciences, The University of Melbourne, Victoria 3010, Australia
    J Biol Chem 278:16587-94. 2003
    The development of high myopia is associated with reduced scleral collagen accumulation, scleral thinning, and loss of scleral tissue, in both humans and animal models...
  44. pmc Association of matrix metalloproteinase gene polymorphisms with refractive error in Amish and Ashkenazi families
    Robert Wojciechowski
    Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland 21224, USA
    Invest Ophthalmol Vis Sci 51:4989-95. 2010
    ..are involved in scleral extracellular matrix remodeling and have shown differential expression in experimental myopia. The genetic association of refractive error and polymorphisms in MMP and TIMP genes in Old Order Amish (AMISH) ..
  45. ncbi Shape of the retinal surface in emmetropia and myopia
    David A Atchison
    Centre for Health Research Optometry, Queensland University of Technology, Brisbane, Queensland, Australia
    Invest Ophthalmol Vis Sci 46:2698-707. 2005
    ..To determine and compare the shapes of the retinas of emmetropic and myopic eyes...
  46. ncbi A genetic perspective on myopia
    F K Jacobi
    Department of Pathophysiology of Vision and Neuro ophthalmology, University Eye Hospital, Schleichstr 12 16, 72076 Tubingen, Germany
    Cell Mol Life Sci 62:800-8. 2005
    b>Myopia is a refractive error of the eye that has a significant socioeconomic impact due to its increasing prevalence and the fact that it causes visual impairment...
  47. ncbi Comparing the ganglion cell complex and retinal nerve fibre layer measurements by Fourier domain OCT to detect glaucoma in high myopia
    Na Rae Kim
    Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, 134 Shinchon dong, Seodaemun gu, Seoul 120 752, Korea
    Br J Ophthalmol 95:1115-21. 2011
    ....
  48. ncbi Biomechanics of the sclera in myopia: extracellular and cellular factors
    Neville A McBrien
    Department of Optometry and Vision Sciences, The University of Melbourne, Victoria, Australia
    Optom Vis Sci 86:E23-30. 2009
    Excessive axial elongation of the eye is the principal structural cause of myopia. The increase in eye size results from active remodelling of the sclera, producing a weakened scleral matrix...
  49. ncbi United States Food and Drug Administration clinical trial of the Implantable Collamer Lens (ICL) for moderate to high myopia: three-year follow-up
    Donald R Sanders
    Center for Clinical Research, Chicago, Illinois, USA
    Ophthalmology 111:1683-92. 2004
    ..To report on 3-year postoperative safety and efficacy outcomes with the Myopic Implantable Collamer Lens (ICL)...
  50. ncbi Homeostasis of eye growth and the question of myopia
    Josh Wallman
    Department of Biology, City College of the City University of New York, New York, New York 10031, USA
    Neuron 43:447-68. 2004
    ..if the match between the length and optics of the eye is under homeostatic control, why do children so commonly develop myopia, and why does the myopia not limit itself? Long-neglected studies may provide an answer to this last question.
  51. ncbi Head-mounted goggles for murine form deprivation myopia
    Amanda E Faulkner
    Rehab R and D Center, Atlanta VAMC, Decatur, GA, USA
    J Neurosci Methods 161:96-100. 2007
    Recently a murine model has been developed for use in form deprivation myopia experiments. Due to the small size of the head and eye, methods to blur visual input to the mouse eye are challenging...
  52. ncbi Laser subepithelial keratomileusis: electron microscopy and visual outcomes of flap photorefractive keratectomy
    D T Azar
    Corneal and Refractive Surgery Services, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    Curr Opin Ophthalmol 12:323-8. 2001
    Laser epithelial keratomileusis (LASEK) is a surgical technique that may be performed in patients with low myopia who are considering conventional photorefractive keratectomy (PRK), in patients with thin corneas, and in patients with ..
  53. pmc Assessment of axial length measurements in mouse eyes
    Han Na Park
    Department of Ophthalmology, School of Medicine, Emory University, Atlanta, Georgia, USA
    Optom Vis Sci 89:296-303. 2012
    ..To compare measurements of murine ocular axial lengths (ALs) made with 780 nm partial coherence interferometry (PCI) and 1310 nm spectral domain-optical coherence tomography (SD-OCT)...
  54. ncbi The association between time spent outdoors and myopia using a novel biomarker of outdoor light exposure
    Justin C Sherwin
    Centre for Eye Research Australia, University of Melbourne, Department of Ophthalmology, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia
    Invest Ophthalmol Vis Sci 53:4363-70. 2012
    We sought to determine whether conjunctival ultraviolet autofluorescence (UVAF), a biomarker of outdoor light exposure, is associated with myopia.
  55. pmc Change in the synthesis rates of ocular retinoic acid and scleral glycosaminoglycan during experimentally altered eye growth in marmosets
    David Troilo
    Department of Biomedical Science and Disease, The New England College of Optometry, Boston, Massachusetts 02115, USA
    Invest Ophthalmol Vis Sci 47:1768-77. 2006
    ..The purpose of this study was to examine the possibility that all-trans-retinoic acid (RA) in the eye is a signal related to changes in scleral extracellular matrix in a primate model of postnatal eye growth...
  56. pmc Experimental murine myopia induces collagen type Iα1 (COL1A1) DNA methylation and altered COL1A1 messenger RNA expression in sclera
    Xiangtian Zhou
    School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China
    Mol Vis 18:1312-24. 2012
    To investigate whether myopia development is associated with changes of scleral DNA methylation in cytosine-phosphate-guanine (CpG) sites in the collagen 1A1 (COL1A1) promoter and messenger RNA (mRNA) levels following murine form ..
  57. ncbi Decreased proteoglycan synthesis associated with form deprivation myopia in mature primate eyes
    J A Rada
    Department of Anatomy and Cell Biology, University of North Dakota School of Medicine and Health Sciences, Grand Forks 58202 9037, USA
    Invest Ophthalmol Vis Sci 41:2050-8. 2000
    ..synthesis was measured in the scleras of adolescent marmosets that had undergone monocular form deprivation to characterize the scleral extracellular matrix changes associated with the development of myopia in a mature primate.
  58. pmc Cornea lenticule viability and structural integrity after refractive lenticule extraction (ReLEx) and cryopreservation
    Karim Mohamed-Noriega
    Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore
    Mol Vis 17:3437-49. 2011
    ..To assess and compare keratocyte viability and collagen structure in cornea stroma lenticules collected immediately after refractive lenticule extraction (ReLEx) and one month after cryopreservation...
  59. ncbi Evaluation of peripapillary intrachoroidal cavitation with swept source and enhanced depth imaging optical coherence tomography
    Richard F Spaide
    Vitreous, Retina, Macula Consultants of New York and the LuEsther T Mertz Retina Research Center, Manhattan Eye, Ear and Throat Hospital, New YorkNY 10022, USA
    Retina 32:1037-44. 2012
    ....
  60. ncbi Early clinical outcomes, including efficacy and endothelial cell loss, of refractive lenticule extraction using a 500 kHz femtosecond laser to correct myopia
    Kazutaka Kamiya
    Department of Ophthalmology, University of Kitasato School of Medicine, Kanagawa, Japan
    J Cataract Refract Surg 38:1996-2002. 2012
    To assess the early clinical outcomes, including the efficacy and the endothelial cell loss, of femtosecond lenticule extraction using a 500 kHz femtosecond laser system to correct myopia.
  61. ncbi Role of the corneal epithelium in refractive changes following laser in situ keratomileusis for high myopia
    L Spadea
    Department of Ophthalmology, University of L Aquila, Italy
    J Refract Surg 16:133-9. 2000
    ..We evaluated the role of the epithelium following excimer laser in situ keratomileusis (LASIK) performed on highly myopic eyes...
  62. ncbi Predictors for the outcome of small-incision lenticule extraction for Myopia
    Jesper Ø Hjortdal
    Department of Ophthalmology, Aarhus University Hospital, Denmark
    J Refract Surg 28:865-71. 2012
    To study the influence of patient- and surgery-related parameters on the predictability, efficacy, and safety of small-incision lenticule extraction (SMILE) for treatment of myopia.
  63. ncbi High prevalence of myopia and high myopia in 5060 Chinese university students in Shanghai
    Jing Sun
    Department of Ophthalmology, Ninth People s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Invest Ophthalmol Vis Sci 53:7504-9. 2012
    b>Myopia is an important cause of correctable visual impairment worldwide. Genetic and environmental factors contribute to its development...
  64. ncbi Choroidal neovascularization in pathological myopia
    Kumari Neelam
    Department of Ophthalmology and Visual Sciences, Khoo Teck Puat Hospital, Singapore
    Prog Retin Eye Res 31:495-525. 2012
    ..in Asian countries is particularly significant due to rising trend in the prevalence and severity of pathological myopia. The exact pathogenesis of myopic CNV remains unclear and there is paucity of information with respect to ..
  65. ncbi Myopia as a risk factor for open-angle glaucoma: a systematic review and meta-analysis
    Michael W Marcus
    Department of Ophthalmology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Ophthalmology 118:1989-1994.e2. 2011
    To determine the association between myopia and open-angle glaucoma.
  66. pmc SLITRK6 mutations cause myopia and deafness in humans and mice
    Mustafa Tekin
    John P Hussman Institute for Human Genomics and Dr John T Macdonald Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    J Clin Invest 123:2094-102. 2013
    b>Myopia is by far the most common human eye disorder that is known to have a clear, albeit poorly defined, heritable component...
  67. ncbi Spherical aberration after laser in situ keratomileusis and photorefractive keratectomy. Clinical results and theoretical models of etiology
    Peter S Hersh
    Institute of Ophthalmology and Visual Science, UMDNJ New Jersey Medical School, Newark, NJ, USA
    J Cataract Refract Surg 29:2096-104. 2003
    ..To assess changes in corneal asphericity after laser refractive surgery and mathematically model possible causes of the changes...
  68. pmc Whole-exome sequencing identifies mutations in GPR179 leading to autosomal-recessive complete congenital stationary night blindness
    Isabelle Audo
    Institut National de la Sante et de la Recherche Medicale, Paris, France
    Am J Hum Genet 90:321-30. 2012
    ..Interestingly, Gpr179 was highly concentrated in horizontal cells and Müller cell endfeet. The involvement of these cells in cCSNB and the specific function of GPR179 remain to be elucidated...
  69. pmc Mutations in zebrafish lrp2 result in adult-onset ocular pathogenesis that models myopia and other risk factors for glaucoma
    Kerry N Veth
    Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
    PLoS Genet 7:e1001310. 2011
    ..and family history, other significant risk factors for glaucoma include elevated intraocular pressure (IOP) and myopia. The complexity of glaucoma has made it difficult to model in animals, but also challenging to identify ..
  70. ncbi Prevalence, incidence, and progression of myopia of school children in Hong Kong
    Dorothy S P Fan
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, Kowloon, Hong Kong, People s Republic of China
    Invest Ophthalmol Vis Sci 45:1071-5. 2004
    To determine the prevalence, incidence, and progression of myopia of Chinese children in Hong Kong.
  71. pmc Insulin, insulin-like growth factor-1, insulin receptor, and insulin-like growth factor-1 receptor expression in the chick eye and their regulation with imposed myopic or hyperopic defocus
    Alexandra Marcha Penha
    University Eye Hospital, Institute for Ophthalmic Research, Section of Neurobiology of the Eye, Tuebingen, Germany
    Mol Vis 17:1436-48. 2011
    ....
  72. ncbi Component dependent risk factors for ocular parameters in Singapore Chinese children
    Seang Mei Saw
    Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Republic of Singapore Singapore Eye Research Institute, Singapore, Republic of Singapore
    Ophthalmology 109:2065-71. 2002
    To examine the risk factors for variations in ocular biometry parameters in Singapore Chinese children, a population with a known high prevalence rate of myopia at an early age.
  73. ncbi Changes in higher order aberrations after wavefront-guided PRK for correction of low to moderate myopia and myopic astigmatism: two-year follow-up
    D Wigledowska-Promienska
    1st Department of Ophthalmology, Silesian University of Medicine, ul Caglana 35, 40 952 Katowice, Poland
    Eur J Ophthalmol 17:507-14. 2007
    ..in higher order aberrations after wavefront-guided photorefractive keratectomy (PRK) in comparison with conventional PRK for low to moderate myopia with myopic astigmatism using a WASCA Workstation with the MEL 70 G-Scan excimer laser.
  74. ncbi IntraLase femtosecond laser vs mechanical microkeratomes in LASIK for myopia: a systematic review and meta-analysis
    Shihao Chen
    The Affiliated Eye Hospital, Wenzhou Medical College, Zhejiang, China
    J Refract Surg 28:15-24. 2012
    ..To evaluate the safety, efficacy, and predictability of IntraLase (Abbott Medical Optics) femtosecond laser-assisted compared to microkeratome-assisted myopic LASIK...
  75. ncbi Laser in situ keratomileusis for myopia and astigmatism: safety and efficacy: a report by the American Academy of Ophthalmology
    Alan Sugar
    Ophthalmic Technology Assessment Committee 2000 2001 Refractive Surgery Panel
    Ophthalmology 109:175-87. 2002
    This document describes laser in situ keratomileusis (LASIK) for myopia and astigmatism and examines the evidence to answer key questions about the efficacy and safety of the procedure.
  76. pmc Replication study of significant single nucleotide polymorphisms associated with myopia from two genome-wide association studies
    Qin Wang
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, 54 Xianlie Road, Guangzhou, China
    Mol Vis 17:3290-9. 2011
    Two previous genome-wide association studies (GWAS) of high myopia in a Japanese population found several single nucleotide polymorphisms (SNPs) associated with the disease...
  77. ncbi Precision of flap measurements for laser in situ keratomileusis in 4428 eyes
    Gerald W Flanagan
    Gordon Binder Vision Institute, San Diego, CA, USA
    J Refract Surg 19:113-23. 2003
    ..To determine the factor(s) that influence the dimensions and predictability of the LASIK corneal flap with the Automated Corneal Shaper (ACS) or the Summit Krumeich Barraquer microkeratome (SKBM)...
  78. pmc Homozygous mutations in ADAMTS10 and ADAMTS17 cause lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature
    Jose Morales
    King Khaled Eye Specialist Hospital, and College of Medicine, King Saud University, Riyadh 11462, Saudi Arabia
    Am J Hum Genet 85:558-68. 2009
    ....
  79. pmc Genetic association of insulin-like growth factor-1 polymorphisms with high-grade myopia in an international family cohort
    Ravikanth Metlapally
    Center for Human GeneticsDepartment of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC 27710, USA
    Invest Ophthalmol Vis Sci 51:4476-9. 2010
    Evidence from human myopia genetic mapping studies (MYP3 locus), modulated animal models, and observations of glycemic control in humans suggests that insulin-like growth factor (IGF)-1 plays a role in the control of eye growth...
  80. ncbi Elevated intraocular pressure and myopic shift linked to topiramate use
    Christian P Guier
    Department of Ophthalmology, Mayo Clinic, Jacksonville, FL 32224, USA
    Optom Vis Sci 84:1070-3. 2007
    The purpose of this report is to describe acute myopia as an ocular adverse reaction to topiramate (Topamax, Ortho-McNeil, Raritan, NJ) and discuss the importance of recognizing this syndrome.
  81. pmc Mitochondrial DNA haplogroup distribution in Chaoshanese with and without myopia
    Qin Wang
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
    Mol Vis 16:303-9. 2010
    ..The objective of this study is to investigate whether an mtDNA background is associated with myopia.
  82. ncbi Refractive errors, intraocular pressure, and glaucoma in a white population
    Tien Yin Wong
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, USA
    Ophthalmology 110:211-7. 2003
    ..To examine the relation of refractive errors to glaucoma and intraocular pressure (IOP) in a defined white population...
  83. ncbi LASIK outcomes in patients with underlying systemic contraindications: a preliminary study
    Rosario Cobo-Soriano
    Clinica Baviera, Instituto Oftalmológico Europeo, Madrid, Spain
    Ophthalmology 113:1118.e1-8. 2006
    ..To determine the anatomic and functional outcomes of photorefractive surgery in patients with underlying systemic diseases that are traditionally listed as relative or absolute contraindications...
  84. ncbi Risk factors for open-angle glaucoma in a Japanese population: the Tajimi Study
    Yasuyuki Suzuki
    Department of Ophthalmology, Teikyo University School of Medicine, Tokyo, Japan
    Ophthalmology 113:1613-7. 2006
    ..To identify the risk factors associated with primary open-angle glaucoma (POAG) in the Tajimi Study...
  85. pmc AC and AG dinucleotide repeats in the PAX6 P1 promoter are associated with high myopia
    Tsz Kin Ng
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong S A R
    Mol Vis 15:2239-48. 2009
    The PAX6 gene, located at the reported myopia locus MYP7 on chromosome 11p13, was postulated to be associated with myopia development...
  86. ncbi Power vector analysis of the optical outcome of refractive surgery
    L N Thibos
    School of Optometry, Indiana University, Bloomington, Indiana 47405, USA
    J Cataract Refract Surg 27:80-5. 2001
    ..To demonstrate the power vector method of representing and analyzing spherocylindrical refractive errors...
  87. ncbi Epidemiologic study of the prevalence and severity of myopia among schoolchildren in Taiwan in 2000
    L L Lin
    Department of Ophthalmology, College of Medicine and Hospital, Taipei, Taiwan
    J Formos Med Assoc 100:684-91. 2001
    BACKGROUND AND PURPOSE: A nationwide survey was performed in 2000 to determine the prevalence and severity of myopia among schoolchildren in Taiwan and to compare these findings with the results of the last survey performed in 1995...
  88. ncbi Expression of collagen-binding integrin receptors in the mammalian sclera and their regulation during the development of myopia
    Neville A McBrien
    Department of Optometry and Vision Sciences, The University of Melbourne, Melbourne, Australia 3010
    Invest Ophthalmol Vis Sci 47:4674-82. 2006
    ..This study identified the major collagen-binding integrin receptors in the mammalian sclera and investigated their mRNA expression during the development of and recovery from experimental myopia.
  89. ncbi Comparison of ray-tracing method and thin-lens formula in intraocular lens power calculations
    Haiying Jin
    International Vision Correction Research Centre, Department of Ophthalmology, University of Heidelberg, Germany
    J Cataract Refract Surg 35:650-62. 2009
    ..To compare the accuracy of the thin-lens and ray-tracing methods in intraocular lens (IOL) power calculations in normal eyes and eyes after corneal refractive surgery...
  90. ncbi LASIK for myopia with Aspheric "aberration neutral" ablations using the ESIRIS laser system
    Maria Clara Arbelaez
    Muscat Eye Laser Center, Muscat, Sultanate of Oman
    J Refract Surg 25:991-9. 2009
    ..To evaluate the clinical outcomes of LASIK using optimized "aberration neutral" ablation profiles...
  91. ncbi Short-term follow-up after implantation of a foldable iris-fixated intraocular lens in phakic eyes
    Mana Tehrani
    Department of Ophthalmology, Johannes Gutenberg University, Mainz, Germany
    Ophthalmology 112:2189-95. 2005
    To evaluate efficiency, predictability, stability, complications, and patient satisfaction after implantation of a foldable iris-fixated phakic intraocular lens (PIOL) for the correction of myopia.
  92. ncbi A retrospective analysis of the first Indian experience on Artisan phakic intraocular lens
    Sirisha Senthil
    Maxivision Eye Hospital, Alladin Mansion, Begumpet, Hyderabad 500 016, India
    Indian J Ophthalmol 54:251-5. 2006
    To evaluate the efficacy, safety, predictability and stability of implanting a polymethylmethacrylate phakic intraocular lens (PIOL) in high myopia.
  93. ncbi Full-thickness macular hole after LASIK for the correction of myopia
    J Fernando Arevalo
    Retina and Vitreous Service, Clinica Oftalmologica Centro Caracas, Caracas, Venezuela
    Ophthalmology 112:1207-12. 2005
    To describe 19 patients (20 eyes) who developed a macular hole (MH) after undergoing bilateral LASIK for the correction of myopia.
  94. ncbi Two-year follow-up of the Artisan/Verisyse iris-supported phakic intraocular lens for the correction of high myopia
    Majid Moshirfar
    John A Moran Eye Center, Salt Lake City, Utah 84121, USA
    J Cataract Refract Surg 33:1392-7. 2007
    To evaluate the implantation of Artisan/Verisyse phakic intraocular lenses (pIOLs) (Advanced Medical Optics) as an effective and safe method for the correction of high myopia.
  95. ncbi Evidence of shared genes in refraction and axial length: the Genes in Myopia (GEM) twin study
    Mohamed Dirani
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
    Invest Ophthalmol Vis Sci 49:4336-9. 2008
    ..However, no study has attempted to determine whether the correlation between axial length and refraction is explained by shared genetic or environmental factors...
  96. ncbi Wavefront-guided laser in situ keratomileusis using the WaveScan system for correction of low to moderate myopia with astigmatism: 6-month results in 277 eyes
    Nada S Jabbur
    Refractive Surgery Center, The Wilmer Eye Institute, The Johns Hopkins University Jabbur, Baltimore, Maryland, USA
    J Cataract Refract Surg 31:1493-501. 2005
    To assess the safety and effectiveness of wavefront guided LASIK surgery using the Visx WaveScan system for correction of low to moderate myopia with astigmatism.
  97. ncbi Wavefront aberration outcomes of LASIK for high myopia and high hyperopia
    Konrad Pesudovs
    Department of Ophthalmology, Flinders Medical Center and Flinders University of South Australia, Bedford Park, South Australia, Australia
    J Refract Surg 21:S508-12. 2005
    To determine the higher order aberrations at the corneal first surface after conventional LASIK for high myopia and high hyperopia.
  98. ncbi Spontaneous high myopia in one eye will affect the development of form deprivation myopia in the fellow eye
    Yueping Ren
    School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China
    Curr Eye Res 36:513-21. 2011
    ..This study investigated whether spontaneous high myopia in one eye will affect refractive development of the fellow eye treated with form deprivation.
  99. ncbi Refractive error and visual impairment in school children in Northern Ireland
    L O'Donoghue
    School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, BT52 1SA, UK
    Br J Ophthalmol 94:1155-9. 2010
    To describe the prevalence of refractive error (myopia and hyperopia) and visual impairment in a representative sample of white school children.
  100. ncbi Laser-assisted subepithelial keratectomy for myopia: two-year follow-up
    Rudolf Autrata
    Department of Ophthalmology, Masaryk University Hospital, Brno, Czech Republic
    J Cataract Refract Surg 29:661-8. 2003
    ..the clinical results (efficacy, safety, stability, and postoperative pain or discomfort) of laser-assisted subepithelial keratectomy (LASEK) and conventional photorefractive keratectomy (PRK) for the correction of low to moderate myopia.
  101. ncbi Prevalence and progression of myopic retinopathy in Chinese adults: the Beijing Eye Study
    Hai Hua Liu
    Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China
    Ophthalmology 117:1763-8. 2010
    ..To determine the prevalence and progression of myopic retinopathy in Chinese adults...

Research Grants72

  1. Role in Myopia Development of Retinal Pigment Epithelium - A New Therapeutic Targ
    Yan Zhang; Fiscal Year: 2013
    Zhang Y. Role in Myopia Development of Retinal Pigment Epithelium - A New Therapeutic Target ? Project Summary The Mentored Clinical Scientist Research Career Development Award (K08) candidate, Yan Zhang, earned her clinical degrees in ..
  2. Forward Genetics to Identify Complex Gene Interactions Involved in Glaucoma
    Elena V Semina; Fiscal Year: 2010
    ..0% overall. However, specific groups including aged individuals, African-Americans, and those with myopia are at greater risk. For example, for individuals over 40 years of age the incidence of glaucoma is 1.9%...
  3. Structural and Functional Changes in Myopia and Susceptibility to Glaucoma
    Lisa Ostrin; Fiscal Year: 2013
    ..Christine Wildsoet. Myopia (nearsightedness) refers to the condition in which light rays from distant objects come to focus in front of the ..
  4. Mouse model for eyelid disease: Congenital blepharophimosis
    Chia Yang Liu; Fiscal Year: 2013
    ..People with BPES are at an increased risk of developing vision problems such as nearsightedness (myopia) or farsightedness (hyperopia)...
  5. COLLAGEN GENE STRUCTURE AND EXPRESSION
    Bjorn Reino Olsen; Fiscal Year: 2013
    ..Knobloch patients have abnormalities that include high myopia, vitreoretinal degeneration, retinal detachment and midline defects in bones of the skull;some patients have ..
  6. Mechanotransduction in the Ciliary Muscle
    Andrew D Pucker; Fiscal Year: 2013
    ..needed to become an independent translational researcher in the field of ciliary muscle physiology and juvenile myopia. The applicant will gain an understanding of how to induce myopia in the guinea pig, and he will receive advanced ..
  7. The Molecular Genetics of High Myopia
    Terri Lois Young; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Myopia, or nearsightedness, is the most common human eye disorder in the world, and is a significant global public health concern...
  8. MECHANISMS OF OCULAR DEVELOPMENT
    Thomas T Norton; Fiscal Year: 2012
    ..However, nearly 30% of the U.S. population develops axial myopia, in which the eyes are elongated relative to the focal plane...
  9. Asia-ARVO Travel Awards and Symposium
    Sally S Atherton; Fiscal Year: 2010
    ..processing;low vision and blindness rehabilitation;ocular genetics;ocular infection, inflammation, and immunology;myopia and refractive error;and collaborative clinical research...
  10. TRP channel expression and function in ON-bipolar cells
    Robert M Duvoisin; Fiscal Year: 2012
    ..for synaptic transmission between cones and cone bipolar cells, further visual symptoms are apparent such as myopia, hyperopia, nystagmus, and reduced visual acuity...
  11. Gene Discovery in Familial Keratoconus
    Yutao Liu; Fiscal Year: 2013
    ..It is characterized by progressive corneal thinning and protrusion of the thinned corneal, which leads to high myopia and irregular astigmatism...
  12. Micro-RNAs in the Sclera: Role in Ocular Growth, and Implications for Myopia
    Ravikanth Metlapally; Fiscal Year: 2013
    ..independent clinician scientist, contributing to the advancement of our understanding of ocular growth and myopia, and more generally, to vision science research. Dr...
  13. Retinal Mechanisms of Refractive Development
    Machelle T Pardue; Fiscal Year: 2013
    ..When successful, the eye reaches emmetropia or zero refractive error. However, ~25% of the US population develops myopia while only 10% develop hyperopia...
  14. Retinal Laser Burn Abolishes Ocular Immunity Privilege
    Kenyatta G Lucas; Fiscal Year: 2010
    ..This is of interest because lasers are gaining increase usage for treatment of glaucoma, myopia and Age-related macular degeneration...
  15. Genetic Epidemiology of Refractive Error
    DWIGHT EDWARD STAMBOLIAN; Fiscal Year: 2013
    ..Glaucoma is a complication of myopia;prevalence of glaucoma is 4.2% in eyes with low myopia and 4.4% of eyes with moderate to high myopia compared to 1...
  16. Identification of quantitative ocular trait genes in the Beaver Dam Eye
    Alison P Klein; Fiscal Year: 2013
    ..Refractive errors(Myopia and Hyperopia) are a common eye disorders and which lead to blurred vision and visual impairment if not corrected...
  17. The Role of Attention in Self-Regulation
    TRACI L MANN; Fiscal Year: 2012
    ..When those resources are limited in some fashion, the result is a state of affairs we term attentional myopia, in which individuals can focus on only the most salient internal and external cues, to the neglect of more distal ..
  18. MRI Biometry of the Pseudophakic Cadaver Eye
    Susan A Strenk; Fiscal Year: 2010
    ..However, despite this renewed interest in IOLs for the correction of presbyopia (as well as myopia, hyperopia, and astigmatism), many questions remain regarding the: optic and haptic sizing and post-operative ..
  19. REGULATION OF SCLERAL GROWTH AND REMODELING IN MYOPIA
    Jody A Summers; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Myopia is a significant global public health concern...
  20. Circadian Organization of the Retina
    Douglas G McMahon; Fiscal Year: 2013
    ..function, the retina as a model biological clock system, and contribute to our understanding of clinically relevant circadian and dopaminergic retinal mechanisms associated with photoreceptor degeneration and myopia.
  21. Myopia: the role of cone opsin mutations &glasses that control axial elongation
    Jay Neitz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Myopia is a major problem worldwide with the number of affected individuals estimated to be as high as 90% for some Asian countries...
  22. Ocular diurnal rhythms and eye growth
    Debora L Nickla; Fiscal Year: 2012
    In the United States, myopia affects nearly 25% of the population, while in certain other developed countries the proportion of the population affected increases to 80% or more. Pathological myopia is also a leading cause of blindness...
  23. Pediatric Eye Disease Investigator Group Coordinating Center
    RAYMOND KRAKER; Fiscal Year: 2013
    ..in esotropia, 12 protocols in amblyopia, two protocols in nasolacrimal duct obstruction, and one protocol in myopia. In addition, several pilot studies have been conducted...
  24. A DATABASE OF IOL POSITION AND BEHAVIOR
    Susan A Strenk; Fiscal Year: 2010
    ..However, despite this renewed interest in IOLs for the correction of presbyopia (as well as myopia, hyperopia, and astigmatism), many questions remain regarding the: optic and haptic sizing and post-operative ..
  25. Gene-environment-wide interaction studies of ocular refraction
    ROBERT J WOJCIECHOWSKI; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Refractive errors (myopia and hyperopia) are the most widespread human eye disorders. By the year 2020, one third of the world's population-over 2...
  26. Alcohol and Condom Use Resistance in Sexually Coercive/Violent Men
    Kelly Cue Davis; Fiscal Year: 2013
    ..Drawing upon Alcohol Myopia Theory, Alcohol Expectancy Theory, and the Theories of Reasoned Action and Planned Behavior (TRA/TPB), two ..
  27. Effects of alcohol intoxication and arousal on discounting and risk behavior
    TYLER BLAKE WRAY; Fiscal Year: 2012
    ..The alcohol myopia model predicts that, due to alcohol's impact on attention, the behavior of intoxicated individuals who ..
  28. VISION SCIENCE RESEARCH CENTER
    Steven J Pittler; Fiscal Year: 2013
    ..Other areas of research include myopia, biochemistry of the lens and cornea, and vitreous biochemistry...
  29. Short Term Research Training at the New England College of Optometry
    Jane E Gwiazda; Fiscal Year: 2013
    ..b>Myopia is a central theme and is pursued with both animal models and human studies...
  30. Feasibility of a mouse model of myopia
    Andrei V Tkatchenko; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Myopia continues to be a significant health problem with increasing prevalence and high morbidity related to pathological complications associated with high myopia...
  31. RESEARCH ON NORMAL AND ABNORMAL MECHANISMS OF VISION
    Larry A Palmer; Fiscal Year: 2013
    ..molecularbiology);retina (circuitry, computation, neurochemistry, developmental genetics);eye (cataract, myopia, tears);central pathways (physiology, computation);higher processes (psychophysics, cognitive neuroscience, ..
  32. Imaging the fronto-limbic-striatal circuit in adolescent cannabis users
    JOHN CLYBURN CHURCHWELL; Fiscal Year: 2010
    ..Underdeveloped cortical structures, such as prefrontal cortex, may also lead to myopia for future outcomes...
  33. Alcohol Myopia and Aggression
    Peter R Giancola; Fiscal Year: 2013
    ..provided by applicant): This application has 2 main goals: 1) to test a psychological model [the Alcohol Myopia Model (AMM);Steele &Josephs, 1990] that can explain the relation between alcohol intoxication and aggression ..
  34. Near Infrared Detector for Advanced Ophthalmology
    Richard Myers; Fiscal Year: 2013
    ..This information will be used in their studies to better understand the pathogenesis of Pathological Myopia.
  35. Alcohol Effects on Cognitive &Affective Mediation of Women's Decision Making
    Jeanette Norris; Fiscal Year: 2013
    ..mediate the influence of background and situational factors on emotional responses and sexual outcomes;2) Alcohol Myopia Theory (Taylor &Leonard, 1983), which explicates the influence of alcohol-related cognitive impairment on ..
  36. Analysis of the Data from Vision in Preschoolers (VIP) Study
    Gui Shuang Ying; Fiscal Year: 2010
    ..moderately severe), all VIP-targeted vision conditions, and for detecting each specific type of refractive error (myopia, hyperopia, astigmatism, and anisometropia) with various levels of severity, by using receiver operating ..
  37. Mechanisms underlying emmetropization and local eye growth regulation
    CHRISTINE FRANCES WILDSOET; Fiscal Year: 2012
    ..b>Myopia, or shortsightedness, is the failure of emmetropization in which the eye grows too long for its optical power...
  38. Optical Coherence Elastography of the Cornea
    Kirill V Larin; Fiscal Year: 2013
    ..characteristics of the ocular globe and may be altered in several disease states including axial elongation in myopia, pathological deformation in keratoconus, and iatrogenic keratoectasia following corneal refractive surgery...
  39. Neurocognitive Deficits, Substance Use, and HIV Risk Behavior
    Sarit A Golub; Fiscal Year: 2010
    ..g. impulsivity, sensation seeking, myopia) and HIV risk behavior...
  40. Optical coherence tomography equipped wavefront system for studying accommodation
    Ji chang He; Fiscal Year: 2013
    ..leads to presbyopia in almost every eye and meanwhile inaccurate accommodation increases the risk to develop myopia in schoolchildren...
  41. Signaling and Gene Interactions Underlying Glaucoma Risk Phenotypes
    Brian A Link; Fiscal Year: 2013
    ..Risk factors include age, family history, anterior segment dysgenesis, elevated intraocular pressure, and high myopia. The complex nature and constraints of traditional genetic approaches in humans and mammalian model systems has ..
  42. Drug Abuse, Social Decision-Making, and Sex-Related Functional Brain Asymmetry
    DANIEL T TRANEL; Fiscal Year: 2010
    ..deficits in VMPC patients have striking similarities with those evident in drug and alcohol abusers and addicts ("myopia for the future")...
  43. Alcohol Use and Sex in College: Developmental Change and Situational Fluctuations
    Jennifer L Maggs; Fiscal Year: 2010
    ..data/Analyses will test predictions from alcohol expectancy models, alcohol myopia theory, and a routine activities perspective on situational deviance using latent growth curve modeling and multi-..
  44. EPIKERATOPHAKIA: THE SURGICAL CORRECTION OF APHAKIA
    MARGUERITE MC DONALD; Fiscal Year: 1991
    ..grafts have been used to treat keratoconus, and epikeratophakia lenses have been shaped to correct unilateral high myopia, and more recently for bilateral high myopia in children and adults with extraordinary amounts of optical ..
  45. MYOPIA DEVELOPMENT IN CHILDREN
    KARLA S ZADNIK; Fiscal Year: 2010
    ..Longitudinal Study of Myopia (OLSM)...
  46. MECHANISMS OF RETINAL SYNAPTIC PLASTICITY
    Douglas McMahon; Fiscal Year: 2009
    ..retinal function and will contribute to our understanding of clinically relevant dopaminergic mechanisms associated with photoreceptor degeneration, myopia, and visual deficits in Parkinsonism and diabetic retinopathy.
  47. Alcohol, Relationships and Risk: Women and HIV
    TINA M ZAWACKI; Fiscal Year: 2013
    ..are the Cognitive Mediation Model of Sexual Decision Making (Norris, Masters, &Zawacki, 2004), Alcohol Myopia Theory (Taylor &Leonard, 1983), and Alcohol Expectancy Theory (MacAndrew &Edgerton, 1969)...
  48. MRI Biometry of the Pseudophakic Cadaver Eye
    Susan Strenk; Fiscal Year: 2007
    ..However, despite this renewed interest in IOLs for the correction of presbyopia (as well as myopia, hyperopia, and astigmatism), results have been disappointing and many questions remain regarding the optic and ..
  49. Novel Tissue-Engineered Treatments for Myopia Control
    CHRISTINE FRANCES contact WILDSOET; Fiscal Year: 2010
    Biopolymer Application for Myopia Control Abstract Significance: This proposal describes a novel approach to the prevention and treatment of myopia (near- sightedness), which results from increased scleral remodeling, leading to ..
  50. MECHANISMS OF RETINAL SYNAPTIC PLASTICITY
    Douglas G McMahon; Fiscal Year: 2013
    ..understanding normal retinal function and contribute to our understanding of clinically relevant dopaminergic mechanisms associated with photoreceptor degeneration, myopia, and visual deficits in Parkinsonism and diabetic retinopathy.
  51. DYNAMIC ANALYSES OF SINGLE MOTHERHOOD
    LAWRENCE L WU; Fiscal Year: 2010
    ..versus contraception, we develop and estimate formal behavioral models to clarify the potential roles of myopia, time inconsistency, uncertainty, and misperception bias...
  52. Ocular Growth, Emmetropia, and Interphotoreceptor Retinoid-Binding Protein (IRBP)
    John M Nickerson; Fiscal Year: 2013
    ..In testing this hypothesis, we unexpectedly find that IRBP knockout (KO) mice develop high myopia, with aberrant eye growth starting after P7 and before P10, well before eyes open...
  53. Technology Development of Electromagnetically Tracked Flexible Endoscope
    LOUISE ANN contact MAWN; Fiscal Year: 2010
    ..We plan to solve the myopia problem and provide the needed information of where the endoscope is and what it is looking at...
  54. Homocysteine's role in the causation of presbyopia
    CHARLES PRINCE; Fiscal Year: 2002
    ..commonly observed pathological changes related to the eye are ectopia lentis preceded by presbyopia and severe myopia. We propose the hypothesis that mild to moderate hyperhomocysteinemia is a risk factor for presbyopia...
  55. Translating Drinking and Driving Risk Information into Risk Perception
    Mark B Johnson; Fiscal Year: 2013
    ..Second, the research will show that alcohol consumption (via the phenomenon of alcohol myopia) exacerbates the effect of cognitive manipulation...
  56. Video Vignettes: Measuring Risk Perception in Alcohol-Related Sexual Assault
    KATHLEEN A PARKS MARSH; Fiscal Year: 2012
    ..At greater levels of alcohol consumption, women may fail to recognize (e.g., alcohol myopia) risk cues for impending SA which may result in failure to extract themselves from a high risk situation (Norris ..
  57. Effects of Alcohol Intoxication and Neurocognitive Processing on Partner Violence
    ROSALITA CRUZ MALDONADO; Fiscal Year: 2013
    ..Drawing on the Alcohol Myopia Model (AMM;Steele &Josephs, 1990), the present study utilizes an experimental approach to test the impact of ..
  58. COLLAGEN GENE EXPRESSION DURING SCLERAL MATURATION
    MARK ZORN; Fiscal Year: 1991
    b>Myopia affects approximately 25% of the population of the United States. Of these, 1%-2% develop pathological myopia--the seventh most frequent cause of legal blindness in the U.S. Pathological myopia results in an elongated eye...
  59. OPTICALLY INDUCED ANISOMETROPIA
    Earl L Smith; Fiscal Year: 2013
    ..g., myopia or nearsightedness) and ultimately to develop effective optical treatment strategies that reduce the impact of ..
  60. Novel Treatment for Degenerative Myopia
    JULIA KORNFIELD; Fiscal Year: 2009
    b>Myopia affects 30% of the population in the U.S. and Europe, and 70-90% of the population in some Asian countries. High myopia of greater than 8 diopters affects 0.2 0...
  61. Progression of Myopia
    CHRISTOPHER ANDERSON CLARK; Fiscal Year: 2013
    ..shown to respond to defocus to produce axial length changes that may result in abnormal refractive error, such as myopia. One of the primary receptors that can detect this defocus is the cone photoreceptor, which has a wide variation ..
  62. COLLABORATIVE OBSERVATIONAL STUDY OF MYOPIA IN COMET CHILDREN
    Mitchell M Scheiman; Fiscal Year: 2013
    ..and summarized briefly here: 1) to use mathematical functions (the Gompertz function and others) to model myopia progression in the 58% of COSMICC subjects with progressing myopia and to develop predictive models and test ..
  63. CONTACT LENSES AND MYOPIA (CLAMP) STUDY
    JEFFREY WALLINE; Fiscal Year: 2003
    The Contact Lenses and Myopia Progression (CLAMP) Study will serve two purposes: 1) it will provide the training mechanism for Jeffrey J. Walline, O.D...
  64. Advanced Graduate Training for Optometrists
    KARLA S ZADNIK; Fiscal Year: 2011
    ..funded through cooperative agreements and industry sources, focuses on the areas of such clinical disorders as myopia, keratoconus, low vision, and children's vision problems...
  65. Collaborative Observational Study of Myopia in COMET Children 2 (COSMICC2) Chair
    Jane E Gwiazda; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Limited data are available on the slowing of myopia progression, its eventual stabilization, and related risk factors...
  66. Adaptive Optics Imager for Study of Pediatric Retinal Disorders
    Anne Fulton; Fiscal Year: 2009
    ..b>Myopia and other significant refractive errors are common in subjects with these disorders...
  67. Adjustable Phakic Intraocular Lens
    Shiao Chang; Fiscal Year: 2003
    ..refractive correction has generated interest in the use of phakic IOLs for refractive correction of high myopia. While LASIK has been highly successful for hyperopia and myopia up to approximately 10 D, the correction of ..
  68. MOLECULAR GENETICS OF MYOPIA
    Terri Young; Fiscal Year: 2002
    ..for success by providing support for investigations into the molecular genetics of exaggerate eye growth, or myopia. Myopia, or nearsightedness is a refractive condition of the eyes with high incidence in the United States and one ..
  69. VISION AND ETIOLOGY OF AXIAL MYOPIA
    JOSHUA WALLMAN; Fiscal Year: 2001
    DESCRIPTION (Investigator's Abstract): This project seeks to contribute to the understanding of the etiology of myopia, a leading cause of blindness, by studying the severe myopia produced by deprivation of form vision in chickens...
  70. Analysis of the Whole Genome CNV and SNP Data for Myopia from the SCORM Cohort
    Yi Ju Li; Fiscal Year: 2009
    b>Myopia (nearsightedness) is the most common human eye disorder. Familial aggregation studies have strongly supported that genetic factors play an important role in myopia development...
  71. The Role of Visual Stimuli in Emmetropization and Myopia
    Alan Busby; Fiscal Year: 2006
    ..S. in vision science to obtain expertise and proficiency in research on myopia, emmetropization, and accommodation...
  72. COGNITIVE AND NEURAL MECHANISMS OF SUBSTANCE ABUSE
    Antoine Bechara; Fiscal Year: 2004
    ..The long-term goal of this project is to understand the neurobiological mechanisms underlying this "myopia" for the future in substance addicts...