optic nerve diseases

Summary

Summary: Conditions which produce injury or dysfunction of the second cranial or optic nerve, which is generally considered a component of the central nervous system. Damage to optic nerve fibers may occur at or near their origin in the retina, at the optic disk, or in the nerve, optic chiasm, optic tract, or lateral geniculate nuclei. Clinical manifestations may include decreased visual acuity and contrast sensitivity, impaired color vision, and an afferent pupillary defect.

Top Publications

  1. ncbi Glaucoma: macrocosm to microcosm the Friedenwald lecture
    Harry A Quigley
    Glaucoma Service and Dana Center for Preventive Ophthalmology, Wilmer Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Invest Ophthalmol Vis Sci 46:2662-70. 2005
  2. pmc Progressive ganglion cell loss and optic nerve degeneration in DBA/2J mice is variable and asymmetric
    Cassandra L Schlamp
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI, USA
    BMC Neurosci 7:66. 2006
  3. ncbi Vision- and health-related quality of life in patients with visual field loss after postchiasmatic lesions
    Carolin Gall
    Otto von Guericke University of Magdeburg, Medical Faculty, Institute of Medical Psychology, Magdeburg, Germany
    Invest Ophthalmol Vis Sci 50:2765-76. 2009
  4. pmc The potential role of glutamate transporters in the pathogenesis of normal tension glaucoma
    Takayuki Harada
    Laboratory of Molecular Neuroscience, School of Biomedical Science and Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    J Clin Invest 117:1763-70. 2007
  5. pmc Longitudinal change detected by spectral domain optical coherence tomography in the optic nerve head and peripapillary retina in experimental glaucoma
    Nicholas G Strouthidis
    Optic Nerve Head Research Laboratory, Devers Eye Institute, Legacy Health System, Portland, OR 97208 3950, USA
    Invest Ophthalmol Vis Sci 52:1206-19. 2011
  6. pmc Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma
    Gareth R Howell
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Cell Biol 179:1523-37. 2007
  7. pmc High-dose radiation with bone marrow transfer prevents neurodegeneration in an inherited glaucoma
    Michael G Anderson
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Proc Natl Acad Sci U S A 102:4566-71. 2005
  8. pmc Optical coherence tomography longitudinal evaluation of retinal nerve fiber layer thickness in glaucoma
    Gadi Wollstein
    New England Eye Center, Tufts New England Medical Center, Tufts University School of Medicine, Boston, Mass, USA
    Arch Ophthalmol 123:464-70. 2005
  9. ncbi The immune system and glaucoma
    GULGUN TEZEL
    Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, Kentucky, USA
    Curr Opin Ophthalmol 15:80-4. 2004
  10. pmc Ability of cirrus HD-OCT optic nerve head parameters to discriminate normal from glaucomatous eyes
    Jean Claude Mwanza
    Bascom Palmer Eye Institute, Miami Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    Ophthalmology 118:241-8.e1. 2011

Detail Information

Publications275 found, 100 shown here

  1. ncbi Glaucoma: macrocosm to microcosm the Friedenwald lecture
    Harry A Quigley
    Glaucoma Service and Dana Center for Preventive Ophthalmology, Wilmer Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Invest Ophthalmol Vis Sci 46:2662-70. 2005
  2. pmc Progressive ganglion cell loss and optic nerve degeneration in DBA/2J mice is variable and asymmetric
    Cassandra L Schlamp
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI, USA
    BMC Neurosci 7:66. 2006
    ....
  3. ncbi Vision- and health-related quality of life in patients with visual field loss after postchiasmatic lesions
    Carolin Gall
    Otto von Guericke University of Magdeburg, Medical Faculty, Institute of Medical Psychology, Magdeburg, Germany
    Invest Ophthalmol Vis Sci 50:2765-76. 2009
    ....
  4. pmc The potential role of glutamate transporters in the pathogenesis of normal tension glaucoma
    Takayuki Harada
    Laboratory of Molecular Neuroscience, School of Biomedical Science and Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    J Clin Invest 117:1763-70. 2007
    ..We believe these mice are the first animal models of NTG that offer a powerful system for investigating mechanisms of neurodegeneration in NTG and developing therapies directed at IOP-independent mechanisms of RGC loss...
  5. pmc Longitudinal change detected by spectral domain optical coherence tomography in the optic nerve head and peripapillary retina in experimental glaucoma
    Nicholas G Strouthidis
    Optic Nerve Head Research Laboratory, Devers Eye Institute, Legacy Health System, Portland, OR 97208 3950, USA
    Invest Ophthalmol Vis Sci 52:1206-19. 2011
    ....
  6. pmc Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma
    Gareth R Howell
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Cell Biol 179:1523-37. 2007
    ..These experiments provide strong evidence for a local insult to axons in the optic nerve...
  7. pmc High-dose radiation with bone marrow transfer prevents neurodegeneration in an inherited glaucoma
    Michael G Anderson
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Proc Natl Acad Sci U S A 102:4566-71. 2005
    ..Because of the robust protective effect, this treatment offers another tool for studying mechanisms of neuroprotection...
  8. pmc Optical coherence tomography longitudinal evaluation of retinal nerve fiber layer thickness in glaucoma
    Gadi Wollstein
    New England Eye Center, Tufts New England Medical Center, Tufts University School of Medicine, Boston, Mass, USA
    Arch Ophthalmol 123:464-70. 2005
    ..To longitudinally evaluate optical coherence tomography (OCT) peripapillary retinal nerve fiber layer thickness measurements and to compare these measurements across time with clinical status and automated perimetry...
  9. ncbi The immune system and glaucoma
    GULGUN TEZEL
    Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, Kentucky, USA
    Curr Opin Ophthalmol 15:80-4. 2004
    ..Compelling evidence obtained from studies over the last decade strongly suggests the involvement of immune system regulation in cell fate decisions in glia and retinal ganglion cells that lead to glaucomatous optic nerve degeneration...
  10. pmc Ability of cirrus HD-OCT optic nerve head parameters to discriminate normal from glaucomatous eyes
    Jean Claude Mwanza
    Bascom Palmer Eye Institute, Miami Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    Ophthalmology 118:241-8.e1. 2011
    ..Dublin, CA) to discriminate between normal and glaucomatous eyes and to compare them with the discriminating ability of peripapillary retinal nerve fiber layer (RNFL) thickness measurements performed with Cirrus HD-OCT...
  11. pmc Optic nerve head and retinal nerve fiber layer analysis: a report by the American Academy of Ophthalmology
    Shan C Lin
    Ophthalmology 114:1937-49. 2007
    ..To evaluate the current published literature on the use of optic nerve head (ONH) and retinal nerve fiber layer (RNFL) measurement devices in diagnosing open-angle glaucoma and detecting progression...
  12. ncbi In vivo evaluation of focal lamina cribrosa defects in glaucoma
    Saman Kiumehr
    Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, NY 10003, USA
    Arch Ophthalmol 130:552-9. 2012
    ..To assess focal lamina cribrosa (LC) defects in glaucoma using enhanced depth imaging optical coherence tomography and to investigate their spatial relationships with neuroretinal rim and visual field loss...
  13. ncbi Progression detection capability of macular thickness in advanced glaucomatous eyes
    Kyung Rim Sung
    Department of Ophthalmology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea
    Ophthalmology 119:308-13. 2012
    ..To evaluate the progression rate of macular and circumpapillary retinal nerve fiber layer (RNFL) thickness in advanced glaucomatous eyes using spectral domain optical coherence tomography (Cirrus HD-OCT, Carl Zeiss Meditec, Dublin, CA)...
  14. ncbi Risk factors for visual field progression in treated glaucoma
    Carlos Gustavo V De Moraes
    Einhorn Clinical Research Center, New York Eye and Ear Infirmary, 310 E 14th St, New York, NY 10003, USA
    Arch Ophthalmol 129:562-8. 2011
    ..To determine intraocular pressure (IOP)-dependent and IOP-independent variables associated with visual field (VF) progression in treated glaucoma...
  15. ncbi Visualization of the lamina cribrosa using enhanced depth imaging spectral-domain optical coherence tomography
    Eun Ji Lee
    Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea
    Am J Ophthalmol 152:87-95.e1. 2011
    ..To investigate whether the enhanced depth imaging technique (EDI) may improve the visualization of the lamina cribrosa using spectral-domain optical coherence tomography (SD-OCT)...
  16. pmc Lack of neuroprotection against experimental glaucoma in c-Jun N-terminal kinase 3 knockout mice
    Harry A Quigley
    Glaucoma Research Laboratory, Wilmer Eye Institute, 600 North Wolfe Street, Johns Hopkins University School of Medicine, Baltimore, MD 21287 9205, USA
    Exp Eye Res 92:299-305. 2011
    ..Counts of RGC layer cells and optic nerve axons indicate that Jnk3(-/-) mice have an increased number of amacrine cells compared to WT controls...
  17. ncbi Histology of the parapapillary region in high myopia
    Jost B Jonas
    Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht Karls University Heidelberg, Germany
    Am J Ophthalmol 152:1021-9. 2011
    ..To examine histomorphometrically the parapapillary region in highly myopic eyes...
  18. pmc Decreased retinal nerve fibre layer thickness detected by optical coherence tomography in patients with ethambutol-induced optic neuropathy
    Samantha J Chai
    Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, 6565 Fannin NC 205, Houston, TX 77030, USA
    Br J Ophthalmol 91:895-7. 2007
    ..It is difficult to assess the degree of optic nerve damage in patients with ethambutol-induced optic neuropathy, especially just after the onset of visual loss, when the optic disc typically looks normal...
  19. ncbi Mitochondrial dysfunction and glaucoma
    George Y X Kong
    Centre for Eye Research Australia, University of Melbourne and Royal Victorian Eye and Ear Hospital, Australia
    J Glaucoma 18:93-100. 2009
    ..Eliciting the role of mitochondria in glaucoma pathogenesis may uncover novel therapeutic targets for protecting the optic nerve and preventing vision loss in glaucoma...
  20. ncbi Comparison of retinal nerve fiber layer thickness measured by Cirrus HD and Stratus optical coherence tomography
    Kyung Rim Sung
    Department of Ophthalmology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea
    Ophthalmology 116:1264-70, 1270.e1. 2009
    ..To study the relationship between retinal nerve fiber layer (RNFL) thickness measured by time domain (Stratus) and spectral domain (Cirrus HD) optical coherence tomography (OCT)...
  21. ncbi Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: a variability and diagnostic performance study
    Christopher Kai Shun Leung
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, People s Republic of China
    Ophthalmology 116:1257-63, 1263.e1-2. 2009
    ..Dublin, CA) and a time-domain OCT device (Stratus OCT; Carl Zeiss Meditec, Inc.)...
  22. ncbi Diagnostic capability of optical coherence tomography in evaluating the degree of glaucomatous retinal nerve fiber damage
    Ramanjit Sihota
    Glaucoma Research Facility, Dr Rajendra Prasad Center for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi
    Invest Ophthalmol Vis Sci 47:2006-10. 2006
    ..To evaluate the role and ability of optical coherence tomography (OCT) to detect differences in peripapillary retinal nerve fiber layer (RNFL) thickness between normal and glaucomatous eyes and also between different severities of glaucoma...
  23. ncbi Technique for detecting serial topographic changes in the optic disc and peripapillary retina using scanning laser tomography
    B C Chauhan
    Department of Ophthalmology, Dalhousie University, Halifax, Nova Scotia, Canada
    Invest Ophthalmol Vis Sci 41:775-82. 2000
    ..To describe and evaluate a new statistical technique for detecting topographic changes in the optic disc and peripapillary retina measured with confocal scanning laser tomography...
  24. ncbi Genetic etiologies of glaucoma
    Janey L Wiggs
    Department of Ophthalmology, Harvard Medical School, Boston, Mass, USA
    Arch Ophthalmol 125:30-7. 2007
    ....
  25. pmc Use of an adult rat retinal explant model for screening of potential retinal ganglion cell neuroprotective therapies
    Natalie D Bull
    Cambridge Centre for Brain Repair, University of Cambridge, United Kingdom
    Invest Ophthalmol Vis Sci 52:3309-20. 2011
    ....
  26. pmc Longitudinal detection of optic nerve head changes by spectral domain optical coherence tomography in early experimental glaucoma
    Lin He
    Optic Nerve Head Research Laboratory, Devers Eye Institute, Legacy Health, Portland, Oregon
    Invest Ophthalmol Vis Sci 55:574-86. 2014
    ....
  27. ncbi Cataract and glaucoma case detection for Vision 2020 programs in Africa: an evaluation of 6 possible screening tests
    Colin Cook
    Department of Ophthalmology, Groote Schuur Hospital, Observatory, Cape Town, South Africa
    J Glaucoma 18:557-62. 2009
    ..To determine if there is a screening test or a combination of screening tests that may be suitable for cataract and glaucoma case detection in Vision 2020 programs in Africa...
  28. ncbi Modeling individual-specific human optic nerve head biomechanics. Part I: IOP-induced deformations and influence of geometry
    Ian A Sigal
    Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Canada
    Biomech Model Mechanobiol 8:85-98. 2009
    ..Predicted strains within ONH tissues are potentially biologically significant and support the hypothesis that biomechanical factors contribute to the initial insult that leads to RGC loss in glaucoma...
  29. ncbi Optic atrophy 3 as a protein of the mitochondrial outer membrane induces mitochondrial fragmentation
    Seung Wook Ryu
    Cell Signaling and Bioimaging Laboratory, Department of Bio and Brain Engineering, KAIST, Yuseong Gu, Daejeon 305 701, Korea
    Cell Mol Life Sci 67:2839-50. 2010
    ..Together, these results indicate that OPA3, as an integral MOM protein, has a crucial role in mitochondrial fission, and provides a direct link between mitochondrial morphology and optic atrophy...
  30. ncbi Bayesian machine learning classifiers for combining structural and functional measurements to classify healthy and glaucomatous eyes
    Christopher Bowd
    Hamilton Glaucoma Center, Department of Ophthalmology, University of California, San Diego, La Jolla, CA 92037 0946, USA
    Invest Ophthalmol Vis Sci 49:945-53. 2008
    ....
  31. ncbi Animal models of optic nerve diseases
    H Levkovitch-Verbin
    Sam Rothberg Ophthalmic Molecular Biology Laboratory, Goldschleger Eye Institute, Sheba Medical Center, Tel Aviv University, Tel Hashomer, Israel
    Eye (Lond) 18:1066-74. 2004
  32. ncbi Glaucoma diagnostic capabilities of optic nerve head parameters as determined by Cirrus HD optical coherence tomography
    Kyung Rim Sung
    Department of Ophthalmology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea
    J Glaucoma 21:498-504. 2012
    ..0.0.326)...
  33. ncbi Glaucoma versus red disease: imaging and glaucoma diagnosis
    Gabriel T Chong
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Curr Opin Ophthalmol 23:79-88. 2012
    ....
  34. ncbi Short wavelength automated perimetry, frequency doubling technology perimetry, and pattern electroretinography for prediction of progressive glaucomatous standard visual field defects
    Andreas U Bayer
    Department of Ophthalmology, Eberhard Karls University, Tuebingen, Germany
    Ophthalmology 109:1009-17. 2002
    ....
  35. ncbi Detection of glaucomatous progression by spectral-domain optical coherence tomography
    Jung Hwa Na
    Department of Ophthalmology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea
    Ophthalmology 120:1388-95. 2013
    ....
  36. ncbi Factors associated with focal lamina cribrosa defects in glaucoma
    Sung Chul Park
    Moise and Chella Safra Advanced Ocular Imaging Laboratory, Einhorn Clinical Research Center, New York Eye and Ear Infirmary of the Mount Sinai Health System, New York, New York
    Invest Ophthalmol Vis Sci 54:8401-7. 2013
    ..To assess factors associated with focal lamina cribrosa (LC) defects in glaucoma...
  37. ncbi Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: a prospective analysis of age-related loss
    Christopher K S Leung
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, P R China
    Ophthalmology 119:731-7. 2012
    ..To investigate age-related changes of the retinal nerve fiber layer (RNFL) imaged by a spectral-domain optical coherence tomography (OCT)...
  38. ncbi Reversal of lamina cribrosa displacement and thickness after trabeculectomy in glaucoma
    Eun Ji Lee
    Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea
    Ophthalmology 119:1359-66. 2012
    ..To investigate the response of the lamina cribrosa (LC) and prelaminar tissue to glaucoma surgery using spectral-domain optical coherence tomography (SD-OCT) and to determine the factors influencing such responses...
  39. pmc Comparison of different spectral domain OCT scanning protocols for diagnosing preperimetric glaucoma
    Renato Lisboa
    Hamilton Glaucoma Center, Department of Ophthalmology, University of California San Diego, La Jolla, CA, USA
    Invest Ophthalmol Vis Sci 54:3417-25. 2013
    ..To compare the ability of spectral-domain optical coherence tomography (SDOCT) retinal nerve fiber layer (RNFL), optic nerve head (ONH), and macular measurements to detect preperimetric glaucomatous damage...
  40. ncbi Evaluation of lamina cribrosa in pseudoexfoliation syndrome using spectral-domain optical coherence tomography enhanced depth imaging
    Soa Kim
    Department of Ophthalmology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea
    Ophthalmology 120:1798-803. 2013
    ..The results were compared with those of patients with primary open-angle glaucoma (POAG)...
  41. pmc Understanding disparities among diagnostic technologies in glaucoma
    Carlos Gustavo V De Moraes
    Einhorn Clinical Research Center, The New York Eye and Ear Infirmary, and Department of Ophthalmology, New York University School of Medicine, New York, New York 10003, USA
    Arch Ophthalmol 130:833-40. 2012
    ..To investigate causes of disagreement among 3 glaucoma diagnostic techniques: standard automated achromatic perimetry (SAP), the multifocal visual evoked potential technique (mfVEP), and optical coherence tomography (OCT)...
  42. ncbi Astrocytes in glaucomatous optic neuropathy
    M Rosario Hernandez
    Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Prog Brain Res 173:353-73. 2008
    ..Our data also suggests that the creation of a non-supportive environment for the survival of RGC axons through remodeling of the ONH by reactive astrocytes leads to progression of glaucomatous optic neuropathy...
  43. ncbi Changes in retinal nerve fiber layer thickness after acute primary angle closure
    Tin Aung
    Glaucoma Department, Singapore National Eye Center, and National University of Singapore
    Ophthalmology 111:1475-9. 2004
    ..To evaluate the changes in retinal nerve fiber layer (RNFL) thickness in the first 16 weeks after acute primary angle closure (APAC) using scanning laser polarimetry (SLP)...
  44. ncbi Graves ophthalmopathy: the bony orbit in optic neuropathy, its apical angular capacity, and impact on prediction of risk
    L L Chan
    Department of Diagnostic Radiology, Singapore General Hospital, Singapore
    AJNR Am J Neuroradiol 30:597-602. 2009
    ..We examined herein bony and soft-tissue CT features associated with ON, including an angular assessment of orbital apex capacity, and their usefulness in the risk prediction of ON...
  45. ncbi Use of high-resolution MRI of the optic nerve in Graves' ophthalmopathy
    N I Dodds
    Division of Imaging Science and Biomedical Engineering, Stopford Medical School, Manchester, UK
    Br J Radiol 82:541-4. 2009
    ..The study supports the hypothesis and provides further evidence that the likely mechanism of Graves' ophthalmopathy is compression of the optic nerve at the apex...
  46. ncbi Glaucomatous retinal nerve fibre layer defects may be identified in Stratus OCT images classified as normal
    Jesper Leth Hougaard
    Department of Clinical Sciences, Ophthalmology, Malmo University Hospital, Lund University, Malmo, Sweden
    Acta Ophthalmol 86:569-75. 2008
    ..We aimed to compare the retinal nerve fibre layer (RNFL) in different Stratus optical coherence tomography (OCT) images in glaucoma eyes with RNFL thickness values within normal limits...
  47. ncbi Longitudinal changes in retinal nerve fiber layer thickness after acute primary angle closure measured with optical coherence tomography
    Jen Chia Tsai
    Department of Ophthalmology, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta Pei Road, Niao Sung Hsiang, Kaohsiung County 833, Taiwan
    Invest Ophthalmol Vis Sci 48:1659-64. 2007
    ..Longitudinal follow-up of peripapillary retinal nerve fiber layer (RNFL) thickness after an episode of acute primary angle closure (APAC) using Stratus optical coherence tomography (OCT)...
  48. ncbi Frequency-doubling threshold perimetry in predicting glaucoma in a population-based study: The Beijing Eye Study
    Ya Xing Wang
    Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China
    Arch Ophthalmol 125:1402-6. 2007
    ..To determine the predictive value of frequency-doubling threshold perimetry for glaucoma in a population-based study...
  49. pmc Reversal of dysthyroid optic neuropathy following orbital fat decompression
    M Kazim
    Department of Ophthalmology, Edward S Harkness Eye Institute, Columbia Presbyterian Medical Center, New York, NY 10032, USA
    Br J Ophthalmol 84:600-5. 2000
    ..To document the successful treatment of five patients with dysthyroid optic neuropathy by orbital fat decompression instead of orbital bone decompression after failed medical therapy...
  50. ncbi Comparison of retinal nerve fiber layer thickness and optic disk algorithms with optical coherence tomography to detect glaucoma
    Anita Manassakorn
    Glaucoma Division, Jules Stein Eye Institute, University of California Los Angeles, 100 Stein Plaza, Los Angeles, CA 90095, USA
    Am J Ophthalmol 141:105-115. 2006
    ..To compare the performance of the retinal nerve fiber layer (RNFL) thickness and optic disk algorithms as determined by optical coherence tomography to detect glaucoma...
  51. pmc Clinical features of dysthyroid optic neuropathy: a European Group on Graves' Orbitopathy (EUGOGO) survey
    David McKeag
    Centre for Endocrine and Diabetes Sciences, University Hospital of Wales, Cardiff CF 4 4XN, UK
    Br J Ophthalmol 91:455-8. 2007
    ..This study was performed to determine clinical features of dysthyroid optic neuropathy (DON) across Europe...
  52. ncbi Optic nerve degeneration in the DBA/2NNia mouse: is the lamina cribrosa important in the development of glaucomatous optic neuropathy?
    Christian Albrecht May
    Department of Anatomy, Carl Gustav Carus Medical Faculty, TU Dresden, Dresden, Germany
    Acta Neuropathol 111:158-67. 2006
    ..In addition, astrocytes in the ON head form extracellular material similar to that found in human glaucomatous eyes...
  53. ncbi Optic nerve compression in craniofacial fibrous dysplasia: the role and indications for decompression
    Ying Chien Tan
    Department of Plastic Surgery, Singapore General Hospital, Singapore
    Plast Reconstr Surg 120:1957-62. 2007
    ..The approach to visual disturbance caused by disease involvement of the optic canal has been varied and controversial. This is especially the case with regard to surgical decompression, particularly prophylactic decompression...
  54. ncbi Sensitivity and specificity of the Humphrey Matrix to detect homonymous hemianopias
    Parisa Taravati
    Department of Ophthalmology, University of Iowa, Iowa City, Iowa, USA
    Invest Ophthalmol Vis Sci 49:924-8. 2008
    ..To compare the sensitivity and specificity of the Humphrey Matrix frequency-doubling perimeter (Carl Zeiss Meditec, Inc., Dublin, CA) to that of standard automated perimetry (SAP) in detecting homonymous hemianopic visual field defects...
  55. ncbi Optic neuropathies. An overview
    G P Van Stavern
    Neuro-Ophthalmology Unit, Department of Ophthalmology, Emory University School of Medicine, Emory Eye Center, Atlanta, Georgia, USA
    Ophthalmol Clin North Am 14:61-71, viii. 2001
    ..Hereditary, toxic, nutritional, and compressive optic neuropathies often have characteristic clinical findings that may provide clues to a possible diagnosis...
  56. pmc Causes of severe visual impairment and blindness in children in schools for the blind in Ethiopia
    A B Kello
    Christoffel Blindenmission AROE II, Addis Ababa, Ethiopia London School of Hygiene and Tropical Medicine, London, UK
    Br J Ophthalmol 87:526-30. 2003
    ..To determine the causes of severe visual impairment and blindness in children in schools for the blind in Ethiopia, to aid in planning for the prevention and management of avoidable causes...
  57. ncbi Factors influencing optic nerve head biomechanics
    Ian A Sigal
    Department of Mechanical and Industrial Engineering, University of Toronto, Ontario, Canada
    Invest Ophthalmol Vis Sci 46:4189-99. 2005
    ..This was a systematic analysis in which finite element methods were used to determine which anatomic and biomechanical factors most influenced the biomechanical response of the ONH to acute changes in IOP...
  58. ncbi Comparison of macular and peripapillary measurements for the detection of glaucoma: an optical coherence tomography study
    Christopher K S Leung
    Department of Ophthalmology, Caritas Medical Centre, Hong Kong, China
    Ophthalmology 112:391-400. 2005
    ....
  59. ncbi Acute optic nerve infarction demonstrated by diffusion-weighted imaging in a case of rhinocerebral mucormycosis
    S Mathur
    Department of Radiology, University of Illinois Medical Center at Chicago, Chicago, Ill, USA
    AJNR Am J Neuroradiol 28:489-90. 2007
    ..This MR imaging abnormality of optic nerve infarction due to mucormycosis has not been reported previously...
  60. ncbi Long-term outcome of optic nerve encasement and optic nerve decompression in patients with fibrous dysplasia: risk factors for blindness and safety of observation
    Carolee M Cutler
    Department of General and Plastic Reconstructive Surgery, University of Utah, Salt Lake City, Utah, USA
    Neurosurgery 59:1011-7; discussion 1017-8. 2006
    ..Uncertainty exists as to the management of FD involving the optic nerves. In an effort to clarify management, the authors studied a large population of patients...
  61. ncbi Relationship between visual field sensitivity and retinal nerve fiber layer thickness as measured by scanning laser polarimetry
    Patricio G Schlottmann
    Glaucoma Research Unit, Moorfields Eye Hospital, London, United Kingdom
    Invest Ophthalmol Vis Sci 45:1823-9. 2004
    ..To evaluate the strength and pattern of the relationship between visual field (VF) sensitivity and retinal nerve fiber layer (RNFL) thickness measurements by scanning laser polarimetry (SLP)...
  62. ncbi Optic disc and visual field progression in ocular hypertensive subjects: detection rates, specificity, and agreement
    Nicholas G Strouthidis
    Glaucoma Research Unit, Moorfields Eye Hospital, London, United Kingdom
    Invest Ophthalmol Vis Sci 47:2904-10. 2006
    ....
  63. ncbi Evaluation of inducible nitric oxide synthase in glaucomatous optic neuropathy and pressure-induced optic nerve damage
    Iok Hou Pang
    Alcon Research, Ltd, Fort Worth, Texas, USA
    Invest Ophthalmol Vis Sci 46:1313-21. 2005
    ..To determine whether inducible nitric oxide synthase (NOS-2) is involved in glaucomatous optic neuropathy...
  64. pmc Blood vessel contributions to retinal nerve fiber layer thickness profiles measured with optical coherence tomography
    Donald C Hood
    Departments of Psychology and Ophthalmology, Columbia University, New York, NY 10027, USA
    J Glaucoma 17:519-28. 2008
    ..To understand better the influence of retinal blood vessels (BVs) on the interindividual variation in the retinal nerve fiber layer (RNFL) thickness measured with optical coherence tomography (OCT)...
  65. ncbi Biomechanics of the optic nerve head
    Ian A Sigal
    Department of Biomedical Engineering, Tulane University, New Orleans, LA, USA
    Exp Eye Res 88:799-807. 2009
    ..Further modeling, suitably informed by experiments, is needed to better understand lamina cribrosa biomechanics and how they may be involved in glaucomatous optic neuropathy...
  66. pmc Combining functional and structural tests improves the diagnostic accuracy of relevance vector machine classifiers
    Lyne Racette
    Department of Ophthalmology, Hamilton Glaucoma Center, University of California, San Diego, La Jolla, CA 92093 0946, USA
    J Glaucoma 19:167-75. 2010
    ....
  67. ncbi A new statistical approach for quantifying change in series of retinal and optic nerve head topography images
    Andrew J Patterson
    School of Biomedical and Natural Sciences, The Nottingham Trent University, Clifton Campus, Nottingham G11 8NS, United Kingdom
    Invest Ophthalmol Vis Sci 46:1659-67. 2005
    ....
  68. ncbi Characteristics of highly myopic eyes: the Beijing Eye Study
    Liang Xu
    Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China
    Ophthalmology 114:121-6. 2007
    ..To evaluate factors associated with high myopia (defined as a myopic refractive error exceeding -8 diopters) in a population-based study...
  69. pmc Diagnostic ability of Fourier-domain vs time-domain optical coherence tomography for glaucoma detection
    Mitra Sehi
    Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Palm Beach Gardens, Florida 33418, USA
    Am J Ophthalmol 148:597-605. 2009
    ..To compare retinal nerve fiber layer (RNFL) thickness assessments and the discriminating ability of Fourier-domain optical coherence tomography (FD-OCT) with that of time-domain optical coherence tomography (TD-OCT) for glaucoma detection...
  70. ncbi Comparison of Cirrus OCT and Stratus OCT on the ability to detect localized retinal nerve fiber layer defects in preperimetric glaucoma
    Jin Wook Jeoung
    Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea
    Invest Ophthalmol Vis Sci 51:938-45. 2010
    ..To evaluate and compare the diagnostic ability of Cirrus and Stratus optical coherence tomography (OCT) to detect localized retinal nerve fiber layer (RNFL) defects in patients with normal standard automated perimetry...
  71. ncbi Role of frequency doubling perimetry in detecting neuro-ophthalmic visual field defects
    D Thomas
    Schell Eye Hospital, Department of Ophthalmology, Christian Medical College, Vellore, India
    Am J Ophthalmol 131:734-41. 2001
    ..A normal 20-5 program (absence of a single abnormal point) almost "rules out" a defect. Frequency doubling perimetry could not accurately categorize hemianopic, quadrantanopic, or glaucomatous defects...
  72. pmc Dysthyroid optic neuropathy: a clinical diagnosis or a definable entity?
    Colin M Dayan
    Br J Ophthalmol 91:409-10. 2007
  73. pmc The mouse pattern electroretinogram
    Vittorio Porciatti
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Doc Ophthalmol 115:145-53. 2007
    ..While the use of the PERG as a tool to probe inner retina function in mammals is known since 25 years, relatively less information is available for the mouse. Here, the PERG technique and the main applications in the mouse are reviewed...
  74. ncbi Optic nerve head structure in glaucoma: astrocytes as mediators of axonal damage
    J E Morgan
    Department of Ophthalmology, University of Wales College of Medicine, Cardiff, UK
    Eye (Lond) 14:437-44. 2000
    ....
  75. ncbi Focal lamina cribrosa defects associated with glaucomatous rim thinning and acquired pits
    Jae Young You
    Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, NY 10003, USA
    JAMA Ophthalmol 131:314-20. 2013
    ....
  76. ncbi Reversal of lamina cribrosa displacement after intraocular pressure reduction in open-angle glaucoma
    Eun Ji Lee
    Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea
    Ophthalmology 120:553-9. 2013
    ..To compare the change in lamina cribrosa (LC) displacement in response to intraocular pressure (IOP) lowering in patients with open-angle glaucoma (OAG) using spectral-domain optical coherence tomography (SD-OCT)...
  77. ncbi Reasons for rim area variability in scanning laser tomography
    James C H Tan
    Moorfields Eye Hospital, London, United Kingdom
    Invest Ophthalmol Vis Sci 44:1126-31. 2003
    ..To determine reasons for rim area variability in scanning laser tomography...
  78. ncbi Evaluation of retinal nerve fiber layer progression in glaucoma: a comparison between spectral-domain and time-domain optical coherence tomography
    Christopher Kai Shun Leung
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, People s Republic of China
    Ophthalmology 118:1558-62. 2011
    ..To compare the performance of a spectral-domain optical coherence tomography (OCT) device and a time-domain OCT device to detect retinal nerve fiber layer (RNFL) progression in glaucoma patients...
  79. ncbi Ranking of optic disc variables for detection of glaucomatous optic nerve damage
    J B Jonas
    Department of Ophthalmology, Friedrich Alexander University Erlangen Nurnberg, Germany
    Invest Ophthalmol Vis Sci 41:1764-73. 2000
    ....
  80. ncbi Macular imaging for glaucoma using spectral-domain optical coherence tomography: a review
    Jessica J Wong
    Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Glaucoma Service, Harvard Medical School, Boston, MA, USA
    Semin Ophthalmol 27:160-6. 2012
    ....
  81. pmc Performance of time-domain and spectral-domain Optical Coherence Tomography for glaucoma screening
    Boel Bengtsson
    Department of Clinical Sciences, Ophthalmology in Malmö, Skånes University Hospital, Malmo, Sweden
    Acta Ophthalmol 90:310-5. 2012
    ....
  82. pmc Glaucomatous progression in series of stereoscopic photographs and Heidelberg retina tomograph images
    Neil O'Leary
    Department of Optometry and Visual Science, City University London, Northampton Square, London EC1V 0HB, United Kingdom
    Arch Ophthalmol 128:560-8. 2010
    ..To compare optic disc changes using automated analysis of Heidelberg retina tomograph (HRT) images with assessments, by glaucoma specialists, of change in stereoscopic photographs...
  83. ncbi SITA visual field testing in children
    S P Donahue
    Department of Ophthalmology and Visual Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 8808, USA
    J AAPOS 5:114-7. 2001
    ..The standard SITA algorithm shortens test time in adults without increasing variability, but its usefulness for detecting field defects in children has not been investigated...
  84. ncbi Observer experience and Cup:Disc ratio assessment
    S Hanson
    Department of Optometry and Vision Science, The University of Auckland, New Zealand
    Optom Vis Sci 78:701-5. 2001
    ..However, the agreement between different observers in assessing the C:D ratio (interobserver agreement) increases with experience...
  85. ncbi Neuro-ophthalmic sarcoidosis
    Yanny L Phillips
    Department of Neurology and Ophthalmology, Michigan State University, East Lansing, Michigan, USA
    Curr Opin Ophthalmol 21:423-9. 2010
    ..This review coalesces current literature on the neuro-ophthalmic manifestations of sarcoidosis and discusses the epidemiology, etiology, clinical presentation, diagnosis, and management of this disease...
  86. ncbi Measurement variability in Heidelberg Retina Tomograph imaging of neuroretinal rim area
    Victoria M F Owen
    Department of Optometry and Visual Science, City University, London, United Kingdom
    Invest Ophthalmol Vis Sci 47:5322-30. 2006
    ....
  87. ncbi Utilization of artificial neural networks in the diagnosis of optic nerve diseases
    Sadik Kara
    Department of Electrical and Electronics Engineering, Erciyes University, 38039 Kayseri, Turkey
    Comput Biol Med 36:428-37. 2006
    ..Testing results were found to be compliant with the expected results that are derived from the physician's direct diagnosis. The end benefit would be to assist the physician to make the final decision without hesitation...
  88. ncbi Retinal nerve fiber layer analysis in the diagnosis of glaucoma
    Linda M Zangwill
    Hamilton Glaucoma Center, Department of Ophthalmology, University of California, La Jolla, California 92093 0946, USA
    Curr Opin Ophthalmol 17:120-31. 2006
    ....
  89. ncbi Optic neuropathy in cancer patients. Report of a case possibly related to 5 fluorouracil toxicity and review of the literature
    L Delval
    Service de Médecine Interne et Laboratoire d Investigations Cliniques, Centre des Tumeurs de l Universite Libre de Bruxelles, Bruxelles, Belgique
    J Neurooncol 60:165-9. 2002
    ..We discuss the differential diagnosis of anterior ON and we suggest that 5FU can be responsible for optic nerve toxicity in patients with DPD deficiency...
  90. ncbi Comparison of quantitative imaging devices and subjective optic nerve head assessment by general ophthalmologists to differentiate normal from glaucomatous eyes
    Roberto M Vessani
    Department of Ophthalmology, University of Sao Paulo Medical School, Brazil
    J Glaucoma 18:253-61. 2009
    ....
  91. pmc Frequency doubling technology perimetry in non-arteritic ischaemic optic neuropathy with altitudinal defects
    C A Girkin
    Optic Nerve Imaging Center of the University of Alabama at Birmingham, Birmingham, AL, 35233, USA
    Br J Ophthalmol 88:1274-9. 2004
    ..To determine if frequency doubling technology perimetry (FDT) is more sensitive to optic nerve injury in non-arteritic ischaemic optic neuropathy (NAION) than standard automated perimetry (SAP)...
  92. ncbi [Treatment of optic neuropathies--state of the art]
    W Lagreze
    Universitäts Augenklinik Freiburg, Killianstrasse 5, Freiburg
    Klin Monbl Augenheilkd 226:875-80. 2009
    b>Optic nerve diseases have various causes and are together with macular degeneration the most common causes of severe irreversible visual dysfunction...
  93. ncbi Accuracy of combined GDx-VCC and matrix FDT in a glaucoma screening trial
    Marta Toth
    Department of Ophthalmology, Semmelweis University, Budapest, Hungary
    J Glaucoma 16:462-70. 2007
    ..To assess the advantage in glaucoma screening of the use of scanning laser polarimetry with customized cornea compensation (GDx-VCC) combined with Matrix Frequency Doubling Technology (M-FDT) testing...
  94. ncbi Comparison of macular optical coherence tomography findings between postacute retinal artery occlusion and nonacute optic neuropathy
    Nicola G Ghazi
    Department of Ophthalmology, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Retina 30:578-85. 2010
    ..The purpose of this study was to report differentiating optical coherence tomography (OCT) findings between postacute retinal arterial occlusion (PARAO) and nonacute optic neuropathy (NAON)...
  95. pmc Combining nerve fiber layer parameters to optimize glaucoma diagnosis with optical coherence tomography
    Ake Tzu Hui Lu
    Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine of University of Southern California, Los Angeles, California, USA
    Ophthalmology 115:1352-7, 1357.e1-2. 2008
    ..To identify the best combination of Stratus optical coherence tomography (OCT) retinal nerve fiber layer (RNFL) thickness parameters for the detection of glaucoma...
  96. ncbi The optic nerve
    John B Selhorst
    Department of Neurology and Psychiatry, Saint Louis University, St Louis, Missouri 63108, USA
    Semin Neurol 29:29-35. 2009
    ..The chief means of confirming the diagnosis, often neuroimaging, are given, and common treatment modalities are provided...
  97. pmc Predicting dysthyroid optic neuropathy using computed tomography volumetric analyses of orbital structures
    Allan C Pieroni Gonçalves
    Division of Ophthalmology, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    Clinics (Sao Paulo) 67:891-6. 2012
    ..To evaluate the ability of orbital apex crowding volume measurements calculated with multidetector-computed tomography to detect dysthyroid optic neuropathy...
  98. ncbi Retinal nerve fiber layer measurements using laser scanning polarimetry in different stages of glaucomatous optic nerve damage
    N X Nguyen
    Department of Ophthalmology and University Eye Hospital, Friedrich Alexander University Erlangen Nurnberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Graefes Arch Clin Exp Ophthalmol 240:608-14. 2002
    ..To evaluate the diagnostic value of polarimetric measurements of the retinal nerve fiber layer (RNFL) thickness in different stages of glaucomatous optic nerve damage...
  99. ncbi Serum cytokine alteration is associated with optic neuropathy in human primary open angle glaucoma
    Ping Huang
    Peking University Eye Center, Peking University Third Hospital, Peking University, Beijing, China
    J Glaucoma 19:324-30. 2010
    ..The purpose of this study is to compare human serum levels of TH1 and TH2 cytokines between 2 stages of primary open-angle glaucoma (POAG) and nonglaucomatous controls...
  100. ncbi Rapid, painless unilateral vision loss in a 37-year-old healthy woman
    Geert Craenen
    Department of Ophthalmology and Visual Sciences, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
    Surv Ophthalmol 49:343-8. 2004
    ..The aneurysm was treated with coil embolization, which was technically successful but which did not lead to significant improvement in vision...
  101. ncbi Optic disc hemorrhages in glaucoma and ocular hypertension: implications and recommendations
    Tara A Uhler
    Jefferson Medical College of Thomas Jefferson University, USA
    Curr Opin Ophthalmol 19:89-94. 2008
    ..To describe the epidemiology of disc hemorrhages and underscore the importance of detecting these markers of potential glaucomatous damage and progression...

Research Grants62

  1. Novel Mitochondrial Targeted Neuroprotectants for Glaucoma
    Leonard Levin; Fiscal Year: 2009
    b>Optic nerve diseases are common causes of irreversible blindness. Most are incurable or result in permanent visual loss by the time of diagnosis...
  2. Protein kinase inhibitors that promote RGC survival and function
    Donald J Zack; Fiscal Year: 2010
    ..Although the development of neuroprotective strategies for the treatment of the degenerative optic nerve diseases has great potential, and there have been important laboratory advances, neuroprotection- based treatment ..
  3. Studying models and mechanisms of optic nerve diseases.
    Donald C Hood; Fiscal Year: 2013
    ..We seek to improve our ability to detect and understand early damage to the most important region of the eye for everyday functions, the macula. ..
  4. Compact, cost-effective, and operator-friendly fundus camera for early detection
    DAVID MAXWELL KLEINMAN; Fiscal Year: 2010
    ..durable, hand-held and portable camera system for screening, early diagnosis and follow up of retinal and optic nerve diseases, a new affordable imaging system is required...
  5. OPTIC NEUROPATHY FROM MITOCHONDRIAL DERANGEMENT
    Alfredo Sadun; Fiscal Year: 1999
    ..involving impaired mitochondria and the ATP expensive mitochondrial axonal transportation underlies genetic optic nerve diseases such as Leber s metabolic and nutritional diseases such as CEON, and a variety of toxic optic neuropathies ..
  6. PHYSIOLOGICAL ANALYSIS OF OPTIC NERVE DISEASE
    P King Smith; Fiscal Year: 1991
    The main aim is the evaluation and application of a model of optic nerve diseases which assumes that there are four major systems of axons in the optic nerve, which may be selectively damaged by certain diseases...
  7. Compact, cost-effective, and operator-friendly fundus camera for early detection
    DAVID MAXWELL KLEINMAN; Fiscal Year: 2013
    ..the eye by developing an easy-to-use, pocket-sized, inexpensive digital camera for documenting retinal and optic nerve diseases. In order to reduce rates of preventable vision loss, the early diagnosis of treatable eye diseases has ..
  8. Development of an Orbital Endoscope for Neuroprotection
    Louise Mawn; Fiscal Year: 2003
    ..objectives are to design, construct and test an orbital endoscope for visualization and treatment of optic nerve diseases. Clinical applications of the proposed orbital endoscope include implantation of a slow release drug ..
  9. Novel Factors Promoting Retinal Ganglion Cell Growth
    Donald Zack; Fiscal Year: 2007
    ..may have translational, therapeutic benefit in preserving or restoring vision in patients with blinding optic nerve diseases such as glaucoma, optic nerve stroke, and optic neuritis...
  10. MOLECULAR MECHANISM OF RETINAL GANGLION CELL DEATH
    Robert Nickells; Fiscal Year: 2002
    DESCRIPTION (Adapted from applicant's abstract): Retinal ganglion cells die in a variety of optic nerve diseases, the most prevalent of which is glaucoma...
  11. PATHOGENESIS OF GLAUCOMATOUS OPTIC NERVE DAMAGE
    Harry Quigley; Fiscal Year: 2008
    ..Candidate molecules for genetic susceptibility to glaucoma are likely to be identified. ..
  12. Diagnostic Innovations in Glaucoma: Clinical Electrophysiology
    Christopher Bowd; Fiscal Year: 2008
    ..Findings will be important to the clinical community for determining future evidence-based changes in standard of care for glaucoma diagnosis and monitoring. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  13. Eicosanoids and the Outflow Pathways of the Eye
    Robert Weinreb; Fiscal Year: 2008
    ..The results of these studies have important implications for the discovery of new treatments for glaucoma and other vision-threatening eye diseases. ..
  14. OCULAR HYPERTENSION TREATMENT STUDY (OHTS)
    Robert Weinreb; Fiscal Year: 2008
    ....
  15. Low-cost, portable, computer assisted imaging for diabe*
    Michael Abramoff; Fiscal Year: 2008
    ..Our overall aim is to validate and optimize a low-cost, high quality, patient friendly imaging system for the early diagnosis of diabetic retinopathy. ..
  16. Proteomic Analysis of Retinal Ganglion Cell Death in Glaucoma
    GULGUN TEZEL; Fiscal Year: 2010
    ..These studies are expected to provide comprehensive information about the nerve cell death process, thereby allowing new treatment possibilities for 3 million Americans suffering from glaucoma. ..
  17. Quan11tification of Glaucomatous Optic Neuropathy
    Christopher Girkin; Fiscal Year: 2006
    ....
  18. Medical Advice from Glaucoma Informatics (MAGI)
    Michael Goldbaum; Fiscal Year: 2005
    ..In an effort to discover new and use useful information with unsupervised learning, we will mine our data in visual function and structural tests for glaucoma and in specific combinations of population groups. ..
  19. GLAUCOMA-CONNECTIVE TISSUE CHANGES IN OPTIC NERVE HEAD
    M Rosario Hernandez; Fiscal Year: 2008
    ..abstract_text> ..
  20. LIFE AND DEATH OF RETINAL GANGLION CELLS
    Vittorio Porciatti; Fiscal Year: 2007
    ..Such outcomes are significant, since exploiting an animal model for testing neuroprotective strategies that preserve visual function is an important component of future research on treatments for glaucoma. ..
  21. GLAUCOMA SURGICAL OUTCOMES STUDY
    Henry Jampel; Fiscal Year: 2001
    ..The results of the study may allow physicians to reduce the morbidity of glaucoma surgery by altering their indications for surgery, surgical technique, and postoperative follow-up. ..
  22. DATA COORDINATING CENTER FOR EARLY GLAUCOMA TRIAL
    M Leske; Fiscal Year: 2004
    ....
  23. EARLY DETECTION OF GLAUCOMA DAMAGE
    Henry Jampel; Fiscal Year: 2004
    ..This assessment of the RTA and NFA will help to establish their utility as outcome measures for clinical management of glaucoma, epidemiological research, and clinical trials. ..
  24. COLLABORATIVE INITIAL GLAUCOMA TREATMENT STUDY
    Henry Jampel; Fiscal Year: 2002
    ....
  25. OCULAR MELANOMA
    Paul Finger; Fiscal Year: 2003
    ..Standardized clinical and data collection procedures will be employed, and standardized forms will be used in all centers. Central training and certification of all study staff will be required. ..
  26. PREVALENCE AND IMPACT OF GLAUCOMA AMONG THE VERY ELDERLY
    David Friedman; Fiscal Year: 2003
    ..Finally, the interactions between comorbidities (including cognitive deficits) and visual field loss will be explored. ..
  27. Outcome Measures in Idiopathic Intracranial Hypertension
    Deborah Friedman; Fiscal Year: 2008
    ..Acquire the training, mentoring and experience necessary to conduct independent, funded clinical research in ophthalmologic and neurological disorders Obtain a Masters Degree in Public Health/Clinical Investigator track ..
  28. Prevention of Neuronal Damage in Optic Neuritis
    KENNETH SHINDLER; Fiscal Year: 2008
    ..This proposal will serve as an ideal platform for the principal investigator to begin a career aimed at understanding mechanisms of optic nerve damage and its correlation to clinical findings. [unreadable] [unreadable]..
  29. OCULAR HYPERTENSION TREATMENT STUDY (OHTS)
    Donald Budenz; Fiscal Year: 2008
    ....
  30. Genetic Etiologies of Primary Open Angle Glaucoma
    Janey Wiggs; Fiscal Year: 2009
    ..Specific genetic defects will be correlated with clinical phenotype by investigating familial aggregation of clinical parameters and looking for evidence of gene/gene interactions and how these interactions may influence phenotype. ..
  31. LINKAGE STUDY OF JUVENILE GLAUCOMA
    Janey Wiggs; Fiscal Year: 2008
    ..3) Screen candidate genes located in the RIEG2 region on chromosome 13q14. 4) Correlate mutations in genes known to cause glaucoma with clinical phenotypes. ..
  32. 3D Reconstruction of Optic Nerve Heads
    J Downs; Fiscal Year: 2008
    ..Using these 3D reconstructions of the ONH and principles of biomechanical engineering, we can model the mechanical and vascular effects of elevated IOP in glaucoma. [unreadable] [unreadable] [unreadable]..
  33. In Vivo Measurement of Optic Nerve Axon Loss
    JAMES LINDSEY; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  34. Optic Nerve Axon Loss and Metalloproteinases in Glaucoma
    JAMES LINDSEY; Fiscal Year: 2008
    ..These studies will investigate MMP-9 knockout mice and a drug that inhibits MMP activity. ..
  35. Hinxton Retreat Workshop on Membranoproliferative Glomerulonephritis Type II
    Richard Smith; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  36. Testing therapeutic pathways in genetic glaucoma
    RICHARD LIBBY; Fiscal Year: 2004
    ..These experiments will provide insight into pathways responsible for pressure induced RGC degeneration. Additionally these experiments will provide insight into the location of neuronal insults in glaucoma. ..
  37. Membranoproliferative Glomerulonephritis Workshop
    Richard Smith; Fiscal Year: 2004
    ..abstract_text> ..
  38. EGPS/OHTS Collaborative Analysis
    MAE GORDON; Fiscal Year: 2005
    ..A Joint Committee will be responsible for implementing the study, overseeing the analyses and preparing presentations and publications. ..
  39. SHORT WAVELENGTH AUTOMATED PERIMETRY IN THE OHTS TRIAL
    Chris Johnson; Fiscal Year: 2004
    ..Additionally, the prevalence of SWAP deficits in African American patients participating in OHTS will be evaluated to determine whether African-American ocular hypertensives have a higher prevalence of SWAP deficits. ..
  40. COLLABORATIVE INITIAL GLAUCOMA TREATMENT STUDY
    Rohit Varma; Fiscal Year: 2003
    ....
  41. Family Clustering of Incidence & Progression of Cataract
    Barbara Klein; Fiscal Year: 2003
    ..We currently have no funds to support the proposed analyses. We believe this project offers the possibility of examining important hypotheses in a large group of families in a population-based framework. ..
  42. MYOPIA AND OCULAR GROWTH--NEURAL MECHANISMS
    Richard Stone; Fiscal Year: 2004
    ..We hope that our studies will continue to lead to improved understanding of ocular growth and ultimately towards rational approaches to prevent refractive errors in children. ..
  43. HEAT SHOCK PROTEINS AND THEIR ANTIBODIES IN GLAUCOMA
    Martin Wax; Fiscal Year: 2002
    ..Finally, they will utilize a yeast "two-hydrid" system to identify genes encoding potentially novel proteins that bind and interact with retinal heat shock proteins. ..
  44. CLEK-COORDINATING CENTER
    MAE GORDON; Fiscal Year: 2004
    ..The DCC is responsible for the study design, management of study data, monitoring the performance of the Reading Center and participating clinics, preparation of performance reports, analysis of data and presentation of results. ..
  45. GENE EXPRESSION IN AXOTOMIZED RETINAL GANGLION CELLS
    Leonard Levin; Fiscal Year: 2004
    ..The initial insult in most optic nerve diseases is injury to the RGC axon, from either compression, ischemia, inflammation, or transection...
  46. PROGRESSION OF NUCLEAR DENSITY OVER A 10-YEAR INTERVAL
    Barbara Klein; Fiscal Year: 2002
    ....
  47. Mapping RGC susceptibility alleles
    Robert Nickells; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  48. Role of Retinal Microvasculature in Posterior Uveitis
    Justine Smith; Fiscal Year: 2006
    ..The studies should also have implications for unrelated diseases affecting the retinal circulation, as well as tissue-specific inflammations and infections at other body sites. [unreadable] [unreadable]..
  49. Otosclerosis-A Molecular Genetic Study
    Richard Smith; Fiscal Year: 2006
    ....
  50. OCULAR HYPERTENSION TREATMENT STUDY (OHTS)
    Anne L Coleman; Fiscal Year: 2008
    ....
  51. CLINICAL CHARACTERIZATION&GENETICS OF OPTIC NERVE DRUSEN
    Bradley Katz; Fiscal Year: 2005
    ..These data may suggest novel therapies to prevent the visual field loss associated with OND. In addition, these data may yield information about other diseases of the optic nerve. ..
  52. Incidence of late macular degeneration in older women
    Anne Coleman; Fiscal Year: 2006
    ..This will allow the identification of women in SOF who have had progression of their ARM and developed late ARM since 1997 and 1998...
  53. Structure-Function of the Retina With Neuroprotection
    Arthur Weber; Fiscal Year: 2009
    ....
  54. Cell-type Specific Genomics in the Aging Human Retina
    DAVID CALKINS; Fiscal Year: 2007
    ..The information generated will provide a basis for more extensive investigations of the mechanisms that mediate neuronal aging in the retina and brain. [unreadable] [unreadable] [unreadable]..
  55. Transcriptional silencing in damaged retinal ganglia
    Robert Nickells; Fiscal Year: 2004
    DESCRIPTION: (Applicant's Abstract) Retinal ganglion cells die in a variety of optic nerve diseases, the most prevalent of which is glaucoma. The mechanism of cell death is a genetically controlled program with 4 distinct stages...
  56. Molecular Characterization of Chick Retina during Refractive Development
    RICHARD ALAN STONE; Fiscal Year: 2010
    ....
  57. Visual outcomes & quality of life in CMV retinitis
    Jennifer Thorne; Fiscal Year: 2006
    ..abstract_text> ..
  58. CIGTS-2 Optic Disc Reading Center
    Richard Parrish; Fiscal Year: 2005
    ..To provide the Coordinating Center with optic disc progression rates ..
  59. Perimetry and Psychophysics in Glaucoma
    Chris Johnson; Fiscal Year: 2006
    ..Together, these objectives will provide a better understanding of the underlying basis of early glaucomatous damage. ..
  60. Hinxton Conference of Excellence - Dense Deposit Disease: Therapeutic Options
    Richard Smith; Fiscal Year: 2008
    ..We will also publish the proceedings of this meeting and hope this publication will foster continued interest in developing DDD-specific therapies to treat patients with this disease. [unreadable] [unreadable] [unreadable]..
  61. Genetic Studies of Pseudoexfoliation Glaucoma
    Janey Wiggs; Fiscal Year: 2004
    ....