cataract

Summary

Summary: Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed)

Top Publications

  1. ncbi Causes and prevalence of visual impairment among adults in the United States
    Nathan Congdon
    Wilmer Eye Institute, Wilmer 120, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Arch Ophthalmol 122:477-85. 2004
  2. pmc Cat-Map: putting cataract on the map
    Alan Shiels
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Vis 16:2007-15. 2010
  3. ncbi Important causes of visual impairment in the world today
    Nathan G Congdon
    Dana Center for Preventive Ophthalmology, Johns Hopkins University Schools of Medicine and Public Health, Baltimore, MD, USA
    JAMA 290:2057-60. 2003
  4. pmc Mutation altering the miR-184 seed region causes familial keratoconus with cataract
    Anne E Hughes
    Centre for Public Health, The Queen s University of Belfast, Royal Victoria Hospital, Grosvenor Road, Belfast BT12 6BN, Northern Ireland, UK
    Am J Hum Genet 89:628-33. 2011
  5. pmc Genetics of human cataract
    A Shiels
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO, USA
    Clin Genet 84:120-7. 2013
  6. pmc Lutein and zeaxanthin supplementation reduces H2O2-induced oxidative damage in human lens epithelial cells
    Shasha Gao
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
    Mol Vis 17:3180-90. 2011
  7. pmc Danish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficits
    Robert Tamayev
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 107:20822-7. 2010
  8. pmc Cataract blindness--challenges for the 21st century
    G Brian
    Fred Hollows Foundation, Locked Bag 100, Rosebery, New South Wales 1445, Australia
    Bull World Health Organ 79:249-56. 2001
  9. ncbi Age-related cataract
    Penny A Asbell
    Department of Ophthalmology, Mount Sinai School of Medicine, 1 Gustave L Levy Place, Box 1183, New York, NY 10029, USA
    Lancet 365:599-609. 2005
  10. pmc Oxidative stress, lens gap junctions, and cataracts
    Viviana M Berthoud
    Department of Pediatrics, University of Chicago, Chicago, Illinois 60637, USA
    Antioxid Redox Signal 11:339-53. 2009

Research Grants

  1. GENE MANIPULATION & H202 DEGRADATION IN THE OCULAR LENS
    Abraham Spector; Fiscal Year: 2001
  2. DIETARY & GENETIC CONTROL OF ROS DAMAGE TO THE LENS
    Norman S Wolf; Fiscal Year: 2010
  3. Therapeutic Effect of a Novel Antioxidant on Degenerative Eye Disorders
    Nuran Ercal; Fiscal Year: 2012
  4. Suppression of Ocular Scarring - Controlled Delivery of an ALK-5 Inhibitor
    Hiroshi Nakamura; Fiscal Year: 2013
  5. Vision Sciences Training Grant
    Carol A Mason; Fiscal Year: 2013
  6. Environment, Novel Aging Outcomes, and Genetics
    Sung Kyun Park; Fiscal Year: 2013
  7. DEVELOPMENT AND MAINTENANCE OF LENS TRANSPARENCY
    JOHN IRWIN CLARK; Fiscal Year: 2013
  8. VOLUME REGULATION IN NORMAL AND CATARACTOUS LENSES
    Richard T Mathias; Fiscal Year: 2013
  9. 5500 Q-Trap Mass Spectrometer
    Stephen Barnes; Fiscal Year: 2010
  10. PROTEIN KINASE C IN THE LENS
    DOLORES JEAN TAKEMOTO; Fiscal Year: 2010

Detail Information

Publications311 found, 100 shown here

  1. ncbi Causes and prevalence of visual impairment among adults in the United States
    Nathan Congdon
    Wilmer Eye Institute, Wilmer 120, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Arch Ophthalmol 122:477-85. 2004
    ..To estimate the cause-specific prevalence and distribution of blindness and low vision in the United States by age, race/ethnicity, and gender, and to estimate the change in these prevalence figures over the next 20 years...
  2. pmc Cat-Map: putting cataract on the map
    Alan Shiels
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Vis 16:2007-15. 2010
    Lens opacities, or cataract(s), may be inherited as a classic Mendelian disorder usually with early-onset or, more commonly, acquired with age as a multi-factorial or complex trait...
  3. ncbi Important causes of visual impairment in the world today
    Nathan G Congdon
    Dana Center for Preventive Ophthalmology, Johns Hopkins University Schools of Medicine and Public Health, Baltimore, MD, USA
    JAMA 290:2057-60. 2003
  4. pmc Mutation altering the miR-184 seed region causes familial keratoconus with cataract
    Anne E Hughes
    Centre for Public Health, The Queen s University of Belfast, Royal Victoria Hospital, Grosvenor Road, Belfast BT12 6BN, Northern Ireland, UK
    Am J Hum Genet 89:628-33. 2011
    ..of miR-184 (MIR184) is responsible for familial severe keratoconus combined with early-onset anterior polar cataract by deep sequencing of a linkage region known to contain the mutation...
  5. pmc Genetics of human cataract
    A Shiels
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO, USA
    Clin Genet 84:120-7. 2013
    ..The set of genes currently known to be associated with cataract is far from complete, especially for age-related cataract, and there is much additional information to be ..
  6. pmc Lutein and zeaxanthin supplementation reduces H2O2-induced oxidative damage in human lens epithelial cells
    Shasha Gao
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
    Mol Vis 17:3180-90. 2011
    ..studies suggest that dietary intake of lutein and zeaxanthin is inversely related to the risk for senile cataract. The objectives of this work were to investigate the mechanisms by which these nutrients provide anti-cataract ..
  7. pmc Danish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficits
    Robert Tamayev
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 107:20822-7. 2010
    ..Together, the data suggest that clinical dementia in Danish patients occurs via a loss of function mechanism and not as a result of amyloidosis and tauopathy...
  8. pmc Cataract blindness--challenges for the 21st century
    G Brian
    Fred Hollows Foundation, Locked Bag 100, Rosebery, New South Wales 1445, Australia
    Bull World Health Organ 79:249-56. 2001
    b>Cataract prevalence increases with age. As the world's population ages, cataract-induced visual dysfunction and blindness is on the increase. This is a significant global problem...
  9. ncbi Age-related cataract
    Penny A Asbell
    Department of Ophthalmology, Mount Sinai School of Medicine, 1 Gustave L Levy Place, Box 1183, New York, NY 10029, USA
    Lancet 365:599-609. 2005
    b>Cataract, opacification of the lens, is one of the commonest causes of loss of useful vision, with an estimated 16 million people worldwide affected...
  10. pmc Oxidative stress, lens gap junctions, and cataracts
    Viviana M Berthoud
    Department of Pediatrics, University of Chicago, Chicago, Illinois 60637, USA
    Antioxid Redox Signal 11:339-53. 2009
    ..These observations suggest that oxidative stress-induced damage to connexins (and consequent altered intercellular communication) may contribute to cataract formation.
  11. pmc Mutation analysis of CRYAA, CRYGC, and CRYGD associated with autosomal dominant congenital cataract in Brazilian families
    Alessandro Santana
    Cataract Service, Department of Ophthalmology, Faculty of Medical Sciences, Irmandade da Santa Casa de Misericordia de Sao Paulo, Sao Paulo, Brazil
    Mol Vis 15:793-800. 2009
    ..Approximately 50% of all congenital cataract cases may have a genetic cause...
  12. pmc EPHA2 polymorphisms and age-related cataract in India
    Periasamy Sundaresan
    Department of Genetics, Dr G Venkataswamy Eye Research Institute, Aravind Medical Research Foundation, Aravind Eye Hospital, Madurai, Tamil Nadu, India
    PLoS ONE 7:e33001. 2012
    We investigated whether previously reported single nucleotide polymorphisms (SNPs) of EPHA2 in European studies are associated with cataract in India.
  13. pmc TGFbeta induces morphological and molecular changes similar to human anterior subcapsular cataract
    Frank J Lovicu
    Department of Anatomy and Histology and Institute for Biomedical Research, University of Sydney, NSW, Australia
    Br J Ophthalmol 86:220-6. 2002
    ..In the present study the authors have extended their analysis of these cataract models to determine how closely they mimic human cataract...
  14. pmc Genetic polymorphisms of superoxide dismutases, catalase, and glutathione peroxidase in age-related cataract
    Yi Zhang
    Eye Hospital, The First Affiliated Hospital, Harbin Medical University, Harbin, China
    Mol Vis 17:2325-32. 2011
    ..Therefore, we investigate the possible association between polymorphisms of Cu/Zn superoxide dismutase (SOD1), catalase (CAT), and glutathione peroxidase (GPX) genes and age -related cataract development.
  15. pmc Diverse roles of Eph/ephrin signaling in the mouse lens
    Catherine Cheng
    School of Optometry and Vision Science Program, University of California, Berkeley, California, United States of America
    PLoS ONE 6:e28147. 2011
    ..The anterior polar cataract of ephrin-A5⁻/⁻ lenses is correlated with multilayers of aberrant cells that express alpha smooth muscle ..
  16. pmc Characterization of a novel mutation in the CRYBB2 gene associated with autosomal dominant congenital posterior subcapsular cataract in a Chinese family
    Ke Yao
    Eye Center of the 2nd Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, China
    Mol Vis 17:144-52. 2011
    ..To identify the underlying genetic defect in four generations of a Chinese family affected with bilateral congenital posterior subcapsular cataracts...
  17. pmc β- but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia
    Robert Tamayev
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA
    EMBO Mol Med 4:171-9. 2012
    ..Our data and the failures of anti-Aβ therapies in humans advise against targeting γ-secretase cleavage of APP and/or Aβ...
  18. ncbi Association of glutathione S-transferases polymorphisms (GSTM1 and GSTT1) with senile cataract: a meta-analysis
    Lei Sun
    Department of Ophthalmology, Fourth Hospital of Harbin Medical University, Harbin, People s Republic of China
    Invest Ophthalmol Vis Sci 51:6381-6. 2010
    Glutathione S-transferase (GST) polymorphisms have been considered risk factors for the development of senile cataract. However, the results are not consistent...
  19. pmc Structural and aggregation behavior of the human γD-crystallin mutant E107A, associated with congenital nuclear cataract
    Venkata Pulla Rao Vendra
    Hyderabad Eye Research Foundation, L V Prasad Eye Institute, Hyderabad, India
    Mol Vis 16:2822-8. 2010
    To analyze the conformational features and aggregation properties of the mutant protein E107A human γD-crystallin (HGDC), associated with congenital nuclear cataract.
  20. ncbi Prevalence and causes of visual impairment in Chinese adults in urban southern China
    Shengsong Huang
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
    Arch Ophthalmol 127:1362-7. 2009
    ..To assess the prevalence and causes of visual impairment and blindness in adults living in an urban area of southern China...
  21. ncbi Multiplex cytokine analysis of aqueous humor in eyes with primary open-angle glaucoma, exfoliation glaucoma, and cataract
    Yasuyuki Takai
    Department of Ophthalmology, Shimane University Faculty of Medicine, Izumo, Japan
    Invest Ophthalmol Vis Sci 53:241-7. 2012
    To measure levels of various inflammatory cytokines in the aqueous humor of patients with primary open-angle glaucoma (POAG), exfoliation glaucoma (EXG), and senile cataract.
  22. ncbi Smoking and its association with cataract: results of the Andhra Pradesh eye disease study from India
    Sannapaneni Krishnaiah
    L V Prasad Eye Institute, Hyderabad, India
    Invest Ophthalmol Vis Sci 46:58-65. 2005
    ..To investigate the associations between tobacco smoking and various forms of cataracts among the people of a state in India...
  23. pmc Mutation analysis of congenital cataract in a Chinese family identified a novel missense mutation in the connexin 46 gene (GJA3)
    Zhou Zhou
    Department of Ophthalmology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
    Mol Vis 16:713-9. 2010
    To identify the genetic defects in a three-generation Chinese family with congenital nuclear cataract.
  24. ncbi Comprehensive mutational screening in a cohort of Danish families with hereditary congenital cataract
    Lars Hansen
    Wilhelm Johannsen Centre for Functional Genome Research, Institute of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark
    Invest Ophthalmol Vis Sci 50:3291-303. 2009
    Identification of the causal mutations in 28 unrelated families and individuals with hereditary congenital cataract identified from a national Danish register of hereditary eye diseases...
  25. ncbi The lens circulation
    Richard T Mathias
    Department of Physiology and Biophysics, State University of New York at Stony Brook, Stony Brook, New York, NY 11794 8661, USA
    J Membr Biol 216:1-16. 2007
    ..This review covers the membrane transport systems that are believed to generate and direct this internal circulatory system...
  26. ncbi Biologic mechanisms of the protective role of lutein and zeaxanthin in the eye
    Norman I Krinsky
    Department of Biochemistry, School of Medicine and the USDA Jean Mayer Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111 1837, USA
    Annu Rev Nutr 23:171-201. 2003
    ..Although increasing the intake of lutein or zeaxanthin might prove to be protective against the development of age-related macular degeneration, a causative relationship has yet to be experimentally demonstrated...
  27. pmc Congenital cataracts and their molecular genetics
    J Fielding Hejtmancik
    MOGS OGVFB NEI NIH, Building 10, Bethesda, MD 20892, USA
    Semin Cell Dev Biol 19:134-49. 2008
    b>Cataract can be defined as any opacity of the crystalline lens. Congenital cataract is particularly serious because it has the potential for inhibiting visual development, resulting in permanent blindness...
  28. pmc Rapid Assessment of Avoidable Blindness in India
    John Neena
    Community Ophthalmology Unit, Dr RP Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, Delhi State, India
    PLoS ONE 3:e2867. 2008
    ..The study determined magnitude and causes of avoidable blindness in India in 2007 among the 50+ population...
  29. ncbi Plasma lutein and zeaxanthin and other carotenoids as modifiable risk factors for age-related maculopathy and cataract: the POLA Study
    Cécile Delcourt
    Institut National de la Sante et de la Recherche Medicale INSERM, Research Unit U593 for Epidemiology, Public Health and Development, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    Invest Ophthalmol Vis Sci 47:2329-35. 2006
    To assess the associations of plasma lutein and zeaxanthin and other carotenoids with the risk of age-related maculopathy (ARM) and cataract in the population-based Pathologies Oculaires Liées à l'Age (POLA) Study.
  30. ncbi Causes of blindness and visual impairment in urban and rural areas in Beijing: the Beijing Eye Study
    Liang Xu
    Department of Ophthalmology and Eye Hospital, Tongren Hospital, Beijing, China
    Ophthalmology 113:1134.e1-11. 2006
    ..To evaluate the causes of visual impairment and blindness in adult Chinese in an urban and rural region of Beijing, China...
  31. ncbi Oxidative stress in primary open-angle glaucoma
    Vicente Zanon-Moreno
    Ophthalmologic Research Unit Santiago Grisolia, Dr Peset Universitary Hospital, Valencia, Spain
    J Glaucoma 17:263-8. 2008
    ..To analyze oxidative stress in primary open-angle glaucoma (POAG)...
  32. pmc EPHA2 is associated with age-related cortical cataract in mice and humans
    Gyungah Jun
    Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
    PLoS Genet 5:e1000584. 2009
    Age-related cataract is a major cause of blindness worldwide, and cortical cataract is the second most prevalent type of age-related cataract...
  33. pmc Risk factors associated with incident cataracts and cataract surgery in the Age-related Eye Disease Study (AREDS): AREDS report number 32
    Jessica R Chang
    Neurobiology, Neurodegeneration and Repair Laboratory, National Eye Institute National Institutes of Health, Bethesda, Maryland, USA
    Ophthalmology 118:2113-9. 2011
    To investigate potential risk factors associated with incident nuclear, cortical, and posterior subcapsular (PSC) cataracts and cataract surgery in participants in the Age-Related Eye Disease Study (AREDS).
  34. pmc Different consequences of cataract-associated mutations at adjacent positions in the first extracellular boundary of connexin50
    Jun Jie Tong
    Dept of Physiology and Biophysics, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Am J Physiol Cell Physiol 300:C1055-64. 2011
    ..We studied the consequences of two cataract-associated mutations at adjacent positions at the first extracellular boundary in human connexin50 (Cx50), W45S ..
  35. ncbi Prevalence of diabetic retinopathy, cataract and visual impairment in patients with diabetes in sub-Saharan Africa
    Simon J Glover
    Ophthalmology Research Unit, University of Liverpool, Royal Liverpool University Hospital, Liverpool L7 8XP, UK
    Br J Ophthalmol 96:156-61. 2012
    ..We report the prevalence of all grades of retinopathy and associations with systemic parameters in patients attending a secondary care diabetes clinic in Blantyre, Malawi...
  36. ncbi The genetic and molecular basis of congenital cataract
    Alessandro Santana
    Seção de Catarata Congênita, Departamento de Oftalmologia, Irmandade da Santa Casa de Misericordia de Sao Paulo, SP, Brasil
    Arq Bras Oftalmol 74:136-42. 2011
    ..Approximately fifty percent of all congenital cataract cases may have a genetic cause...
  37. pmc A novel 1-bp deletion in PITX3 causing congenital posterior polar cataract
    Vanita Berry
    Department of Genetics, Institute of Ophthalmology, University College London, London, UK
    Mol Vis 17:1249-53. 2011
    Cataracts are the most common cause of blindness worldwide. Inherited cataract is a clinically and genetically heterogeneous disease...
  38. ncbi Epidemiology of age-related cataract
    H R Taylor
    Centre for Eye Research, University of Melbourne, Victoria, Australia
    Eye (Lond) 13:445-8. 1999
    To investigate the aetiology of cataract, it is necessary to measure both the type and severity of lens opacities, as well as the dose and duration of exposure to the putative risk factor...
  39. ncbi Metabolic syndrome components in relation to risk of cataract extraction: a prospective cohort study of women
    Birgitta Ejdervik Lindblad
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Ophthalmology 115:1687-92. 2008
    To investigate the association between metabolic syndrome and some of its components with the incidence of cataract extraction.
  40. pmc Lens aging: effects of crystallins
    K Krishna Sharma
    Department of Ophthalmology, University of Missouri Columbia, 1 Hospital Drive, Columbia, MO 65212, USA
    Biochim Biophys Acta 1790:1095-108. 2009
    ..Age-related lens opacity, or cataract, is the major cause of blindness worldwide...
  41. pmc Population based outcomes of cataract surgery in three tribal areas of Andhra Pradesh, India: risk factors for poor outcomes
    Rohit C Khanna
    Brien Holden Eye Research Centre, L V Prasad Eye Institute, Banjara Hills, Hyderabad, India
    PLoS ONE 7:e35701. 2012
    To report visual outcomes and risk factors for poor outcomes of cataract surgery in three Integrated Tribal Development Agency (ITDA) areas of Andhra Pradesh, India.
  42. ncbi sHSP in the eye lens: crystallin mutations, cataract and proteostasis
    Alice R Clark
    Department of Biological Sciences, Crystallography, Institute of Structural and Molecular Biology, Birkbeck College, Malet Street, London WC1E 7HX, UK
    Int J Biochem Cell Biol 44:1687-97. 2012
    ..Inherited crystallin mutations are a common cause of childhood cataract, whereas miscellaneous changes to the long-lived crystallins cause age-related cataract, the most common cause of ..
  43. ncbi Cataracts among Chernobyl clean-up workers: implications regarding permissible eye exposures
    B V Worgul
    Eye Radiation and Environmental Research Laboratory, Columbia University, New York, New York 10032, USA
    Radiat Res 167:233-43. 2007
    The eyes of a prospective cohort of 8,607 Chernobyl clean-up workers (liquidators) were assessed for cataract at 12 and 14 years after exposure. The prevalence of strictly age-related cataracts was low, as expected (only 3...
  44. pmc Cerulean cataract mapped to 12q13 and associated with a novel initiation codon mutation in MIP
    Xueshan Xiao
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
    Mol Vis 17:2049-55. 2011
    To identify the genetic defect in a large Chinese family with autosomal dominant cerulean cataract.
  45. ncbi The impact of cataract surgery on quality of life
    Ecosse L Lamoureux
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore
    Curr Opin Ophthalmol 22:19-27. 2011
    This review summarizes the recent literature of the impact of cataract surgery from the patient's perspective, with a focus on second-generation patient reported outcome (PRO) measures that used Rasch analysis to explore their data.
  46. ncbi Influence of diabetes and cardiovascular disease on the long-term incidence of cataract: the Blue Mountains eye study
    Jennifer S L Tan
    Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Sydney, New South Wales, Australia
    Ophthalmic Epidemiol 15:317-27. 2008
    To assess associations between diabetes and selected cardiovascular risk factors and long-term incident cataract and cataract surgery.
  47. ncbi Prevalence and vision-related outcomes of cataract surgery in Gujarat, India
    Gudlavalleti V S Murthy
    International Center for Eye Health, London School of Hygiene and Tropical Medicine, London, UK
    Ophthalmic Epidemiol 16:400-9. 2009
    Investigate the prevalence and vision-related outcomes of cataract surgery in an area of high cataract surgical rate.
  48. ncbi Gap junctions or hemichannel-dependent and independent roles of connexins in cataractogenesis and lens development
    J X Jiang
    Department of Biochemistry, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Curr Mol Med 10:851-63. 2010
    ..Recent advances in basic research of lens connexins and the discoveries of clinical disorders as a result of lens connexin dysfunctions are summarized and discussed here...
  49. pmc A G→T splice site mutation of CRYBA1/A3 associated with autosomal dominant suture cataracts in a Chinese family
    Zhenfei Yang
    Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Lab, Beijing, China
    Mol Vis 17:2065-71. 2011
    ..To identify the genetic defect in a five-generation Chinese family with congenital Y-suture cataracts...
  50. ncbi Rapid assessment of avoidable blindness in Nakuru district, Kenya
    Wanjiku Mathenge
    Rift Valley Provincial Hospital, Nakuru, Kenya
    Ophthalmology 114:599-605. 2007
    ..To estimate the prevalence of avoidable blindness in > or =50-year-olds in Nakuru district, Kenya, and to evaluate the Rapid Assessment for Avoidable Blindness (RAAB), a new methodology to measure the magnitude and causes of blindness...
  51. ncbi The cataract-inducing S50P mutation in Cx50 dominantly alters the channel gating of wild-type lens connexins
    Adam M DeRosa
    Department of Physiology and Biophysics and the Graduate Program in Genetics, State University of New York, Stony Brook, NY 11794, USA
    J Cell Sci 120:4107-16. 2007
    Mutations within connexin50 (Cx50) have been linked to various cataract phenotypes...
  52. pmc Increased AβPP processing in familial Danish dementia patients
    Shuji Matsuda
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA
    J Alzheimers Dis 27:385-91. 2011
    ....
  53. ncbi The global burden of cataract
    Gullapalli N Rao
    L V Prasad Eye Institute, Hyderabad, India
    Curr Opin Ophthalmol 22:4-9. 2011
    To review the previous year's literature related to prevalence of blindness in general, blindness due to cataract, cataract surgical coverage (CSC) and cataract surgical rates (CSRs).
  54. pmc Cataract prevalence, cataract surgical coverage and barriers to uptake of cataract surgical services in Pakistan: the Pakistan National Blindness and Visual Impairment Survey
    Z Jadoon
    Pakistan Institute of Community Ophthalmlogy, Kyber Institute of Ophthalmic Medical Sciences, Peshawar, Pakistan
    Br J Ophthalmol 91:1269-73. 2007
    To estimate the prevalence of visual impairment and blindness caused by cataract, the prevalence of aphakia/pseudophakia, cataract surgical coverage (CSC) and to identify barriers to the uptake of cataract services among adults aged >or=..
  55. ncbi The impact of cataract surgery on health related quality of life in Kenya, the Philippines, and Bangladesh
    Sarah Polack
    London School of Hygiene and Tropical Medicine, London, UK
    Ophthalmic Epidemiol 17:387-99. 2010
    To assess the impact of cataract surgery on vision related quality of life (VRQoL) and generic health related quality of life (HRQoL) in Kenya, Bangladesh and the Philippines.
  56. pmc The G18V CRYGS mutation associated with human cataracts increases gammaS-crystallin sensitivity to thermal and chemical stress
    Zhiwei Ma
    National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biochemistry 48:7334-41. 2009
    ..An autosomal dominant cortical progressive cataract has been associated with a G18V mutation in human gammaS-crystallin...
  57. ncbi Rapid assessment of avoidable blindness in Kunming, china
    Min Wu
    Red Cross Hospital, Kunming, Yunnan, China
    Ophthalmology 115:969-74. 2008
    ..impairment (VI) in people aged > or = 50 years in Kunming using the Rapid Assessment for Avoidable Blindness methodology, and to assess the prevalence of a pupillary defect in participants diagnosed as cataract visually impaired.
  58. ncbi Quantitative genetic architecture of parasite-induced cataract in rainbow trout, Oncorhynchus mykiss
    H Kuukka-Anttila
    Department of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland
    Heredity (Edinb) 104:20-7. 2010
    ..infections that cause cataracts in fish. We estimated the heritability of cataract severity and examined phenotypic and genetic correlations between cataract and a set of performance traits ..
  59. pmc The ageing lens and cataract: a model of normal and pathological ageing
    R Michael
    Institut Universitari Barraquer, Universitat Autonoma de Barcelona, Laforja 88, 08021 Barcelona, Spain
    Philos Trans R Soc Lond B Biol Sci 366:1278-92. 2011
    b>Cataract is a visible opacity in the lens substance, which, when located on the visual axis, leads to visual loss. Age-related cataract is a cause of blindness on a global scale involving genetic and environmental influences...
  60. pmc Association of EPHA2 polymorphisms and age-related cortical cataract in a Han Chinese population
    Wei Tan
    Department of Ophthalmology, Research Institute of Field Surgery, Da Ping Hospital, Third Military Medical University, Chongqing, PR China
    Mol Vis 17:1553-8. 2011
    ..for Eph-receptor tyrosinekinase-type A2 (EPHA2) has been shown to be involved in the pathogenesis of age-related cataract (ARC)...
  61. pmc Cataract-causing αAG98R-crystallin mutant dissociates into monomers having chaperone activity
    Murugesan Raju
    Department of Ophthalmology, University of Missouri, Columbia, MO 65212, USA
    Mol Vis 17:7-15. 2011
    The G98R mutation in αA-crystallin is associated with autosomal dominant cataract in humans. We have reported that mutant G98R protein has substrate-dependent chaperone activity...
  62. ncbi Prevalence and causes of blindness, low vision and status of cataract in 50 years and older citizen of Qatar-a community based survey
    Hamad Al Gamra
    Department of Ophthalmology, Hamad Medical Corporation, Doha, Qatar
    Ophthalmic Epidemiol 17:292-300. 2010
    Rapid Assessment for the Avoidable Blindness (RAAB) was conducted in Qatar during 2009. We present the prevalence and determinants of visual disabilities and status of cataract among citizens aged 50 years and older.
  63. pmc A missense mutation in CRYBA4 associated with congenital cataract and microcornea
    Guangkai Zhou
    Department of Ophthalmology, Harbin Medical University The 2nd Affiliated Hospital, Harbin, Heilongjiang, China
    Mol Vis 16:1019-24. 2010
    To identify mutations in a Chinese family with congenital cataract and microcornea.
  64. ncbi Effects of congenital cataract mutation R116H on alphaA-crystallin structure, function and stability
    Min Pang
    State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Tsinghua University, Beijing 100084, PR China
    Biochim Biophys Acta 1804:948-56. 2010
    ..These results suggested that both the aggregation of the mutant upon stress and co-deposition with the target proteins were likely to be responsible for the onset of cataract.
  65. ncbi Prevalence of cataract and pseudophakia/aphakia among adults in the United States
    Nathan Congdon
    Wilmer Eye Institute, Wilmer 120, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Arch Ophthalmol 122:487-94. 2004
    To determine the prevalence of cataract and pseudophakia/aphakia in the United States and to project the expected change in these prevalence figures by 2020.
  66. pmc A case-control study to assess the relationship between poverty and visual impairment from cataract in Kenya, the Philippines, and Bangladesh
    Hannah Kuper
    International Centre for Eye Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Med 5:e244. 2008
    ..The aim of this study was to examine the association between visual impairment from cataract and poverty in adults in Kenya, Bangladesh, and the Philippines.
  67. ncbi Pharmacological prevention of diabetic cataract
    Z Kyselova
    Institute of Experimental Pharmacology, Slovak Academy of Sciences, Dubravska cesta 9, 841 04 Bratislava, Slovakia
    J Diabetes Complications 18:129-40. 2004
    b>Cataract--opacification of the lens--is closely related to diabetes as one of its major late complications...
  68. ncbi Protein oxidation and lens opacity in humans
    F Boscia
    Department of Ophthalmology, University of Bari, Italy
    Invest Ophthalmol Vis Sci 41:2461-5. 2000
    Oxidative damage to lens proteins is a major factor leading to cataract formation. It is of pathogenic importance to determine a threshold of protein oxidation over which opacification of the lens takes place.
  69. ncbi Epidemiologic study of age-related cataracts among an elderly Chinese population in Shih-Pai, Taiwan
    Su Ying Tsai
    Community Medicine Research Center and Institute of Public Health, National Yang Ming University, Taipei, Taiwan
    Ophthalmology 110:1089-95. 2003
    ..The purpose of this study was to determine the prevalence and risk factors for age-related cataracts in a metropolitan elderly Chinese population in Shihpai, Taipei, Taiwan...
  70. ncbi Pediatric cataract surgery in Nepal
    Jaya Thakur
    Tilganga Eye Center, Kathmandu, Nepal
    J Cataract Refract Surg 30:1629-35. 2004
    To describe the first pediatric cataract surgery case series report from Nepal.
  71. ncbi Genetic and environmental factors in age-related nuclear cataracts in monozygotic and dizygotic twins
    C J Hammond
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, Institute of Ophthalmology, London, United Kingdom
    N Engl J Med 342:1786-90. 2000
    ..Age-related cataracts are a major public health problem. The relative importance of genes and environment in the causation of nuclear cataracts, the most common form of age-related cataracts, is not known...
  72. pmc Rapid assessment of avoidable blindness in Western Rwanda: blindness in a postconflict setting
    Wanjiku Mathenge
    Rift Valley Provincial Hospital, Nakuru, Kenya
    PLoS Med 4:e217. 2007
    ....
  73. ncbi Three-dimensional 1060-nm OCT: choroidal thickness maps in normal subjects and improved posterior segment visualization in cataract patients
    Marieh Esmaeelpour
    School of Optometry and Vision Sciences, Cardiff University, Cardiff, UK
    Invest Ophthalmol Vis Sci 51:5260-6. 2010
    ..3D) 1060-nm OCT by generating choroidal thickness (ChT) maps in patients of different ages with different degrees of ametropia and axial lengths and to investigate the effect of cataract grade on OCT retinal imaging quality.
  74. ncbi The heritability of age-related cortical cataract: the twin eye study
    C J Hammond
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
    Invest Ophthalmol Vis Sci 42:601-5. 2001
    A classical twin study was performed to establish the relative importance of genes and environment in cortical cataract.
  75. ncbi Rapid assessment of avoidable blindness and cataract surgical services in kilimanjaro region, Tanzania
    Celestin Habiyakire
    Kilimanjaro Christian Medical College, Tumaini University, Tanzania
    Ophthalmic Epidemiol 17:90-4. 2010
    To estimate the prevalence and causes of avoidable blindness and visual impairment in persons 50 years of age and older, and to assess the impact of cataract surgical services.
  76. ncbi The prevalence of blindness and cataract surgery in rautahat district, Nepal
    Yuddha D Sapkota
    Nepal Netra Jyoti Sangh, Tripureshwor, Kathmandu, Nepal
    Ophthalmic Epidemiol 17:82-9. 2010
    ..Over 14,000 cataract surgeries were performed during this period...
  77. pmc Functions of the intermediate filament cytoskeleton in the eye lens
    Shuhua Song
    Center for Ophthalmic Research Surgery, Brigham and Women s Hospital, and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 119:1837-48. 2009
    ..For instance, mutations in both BFSP1 and BFSP2 cause cataract in humans. We also explore the potential role of BFSP1 and BFSP2 in aging processes in the lens.
  78. ncbi Contributions of polyol pathway to oxidative stress in diabetic cataract
    A Y Lee
    a Institute of Molecular Biology, University of Hong Kong, Pokfulam, Hong Kong, People s Republic of China
    FASEB J 13:23-30. 1999
    ..Despite a more than 100% increase of MDA, oxidative stress plays only a minor role in the development of cataract in this acute diabetic cataract model...
  79. ncbi The epidemiology of cataract in Australia
    C A McCarty
    Centre for Eye Research Australia, East Melbourne, Victoria
    Am J Ophthalmol 128:446-65. 1999
    To describe the prevalence and risk factors for cataract in an Australian population aged 40 years and older.
  80. pmc Mutation analysis of 12 genes in Chinese families with congenital cataracts
    Wenmin Sun
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
    Mol Vis 17:2197-206. 2011
    ..To identify mutations in 12 genes in Chinese families with congenital cataracts...
  81. pmc Prevalence and causes of blindness and visual impairment in Limbe urban area, South West Province, Cameroon
    Joseph Enyegue Oye
    Sight Savers International, West Africa Regional Office, P O Box 18190 KIA, Accra, Ghana
    Br J Ophthalmol 91:1435-9. 2007
    To conduct a rapid assessment of cataract surgical services to estimate the prevalence and causes of blindness and visual impairment in members of the population aged >/=40 years in the Limbe urban area, Cameroon.
  82. ncbi Prevelence and causes of visual impairment and blindness in older adults in an area of India with a high cataract surgical rate
    Gudlavalleti V S Murthy
    International Centre for Eye Health, London School of Hygiene and Tropical Medicine, London
    Ophthalmic Epidemiol 17:185-95. 2010
    The cataract surgical rate (CSR) in Gujarat, India is reported to be above 10,000 per million population...
  83. pmc A Chinese family with progressive childhood cataracts and IVS3+1G>A CRYBA3/A1 mutations
    Yanan Zhu
    Eye Center of the 2nd Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, China
    Mol Vis 16:2347-53. 2010
    ..To characterize the disease-causing mutations in a Chinese family with progressive childhood cataracts...
  84. ncbi Effects of alpha-crystallin on lens cell function and cataract pathology
    Usha P Andley
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Curr Mol Med 9:887-92. 2009
    ..Non-syndromic, hereditary human cataract development is linked to point mutations in the CRYAA and CRYAB genes which encode alphaA and alphaB-crystallin...
  85. pmc Hydrophobic core mutations associated with cataract development in mice destabilize human gammaD-crystallin
    Kate L Moreau
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Biol Chem 284:33285-95. 2009
    ..buried cores (two in the N-terminal domain (N-td) and one in the C-terminal domain (C-td)) cause early onset cataract in mice, presumably an aggregated state of the mutant crystallins...
  86. pmc A splice site mutation in CRYBA1/A3 causing autosomal dominant posterior polar cataract in a Chinese pedigree
    Zhensheng Gu
    Department of Ophthalmology, Xinhua Hospital, Medical College of Shanghai Jiao Tong University, Shanghai, China
    Mol Vis 16:154-60. 2010
    To identify the mutant gene for autosomal dominant posterior polar congenital cataract in a four-generation Chinese pedigree.
  87. pmc A novel mutation in the major intrinsic protein (MIP) associated with autosomal dominant congenital cataracts in a Chinese family
    Wei Wang
    Eye Center of the 2nd Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, China
    Mol Vis 16:534-9. 2010
    ..To detect the underlying genetic defect in a Chinese family affected with bilateral congenital cataracts...
  88. pmc Healthy diets and the subsequent prevalence of nuclear cataract in women
    Julie A Mares
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53726 2336, USA
    Arch Ophthalmol 128:738-49. 2010
    To assess the association between healthy diet scores and prevalence of nuclear cataract in women.
  89. pmc Prevalence of visual impairment, cataract surgery and awareness of cataract and glaucoma in Bhaktapur district of Nepal: the Bhaktapur Glaucoma Study
    Suman S Thapa
    Nepal Glaucoma Eye Clinic, Tilganga Institute of Ophthalmology, Kathmandu, Nepal
    BMC Ophthalmol 11:2. 2011
    b>Cataract and glaucoma are the major causes of blindness in Nepal. Bhaktapur is one of the three districts of Kathmandu valley which represents a metropolitan city with a predominantly agrarian rural periphery...
  90. ncbi Pediatric cataract and surgery outcomes in Central India: a hospital based study
    Rajiv Khandekar
    BCEIO, UBC, Canada
    Indian J Med Sci 61:15-22. 2007
    A review of pediatric cataract cases operated between January 2003 and March 2005 in the tribal belt of central India was carried out.
  91. ncbi Visual risk factors for crash involvement in older drivers with cataract
    C Owsley
    Department of Ophthalmology, Clinical Research Unit, School of Medicine, University of Alabama at Birmingham, 700 S 18th St, Suite 609, Birmingham, AL 35294 0009, USA
    Arch Ophthalmol 119:881-7. 2001
    The Impact of Cataracts on Mobility project has previously demonstrated that older drivers with cataract have an elevated risk of motor vehicle collision.
  92. pmc A 5-bp insertion in Mip causes recessive congenital cataract in KFRS4/Kyo rats
    Kei Watanabe
    Mammalian Genetics Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan
    PLoS ONE 7:e50737. 2012
    We discovered a new cataract mutation, kfrs4, in the Kyoto Fancy Rat Stock (KFRS) background. Within 1 month of birth, all kfrs4/kfrs4 homozygotes developed cataracts, with severe opacity in the nuclei of the lens...
  93. pmc Oxidative damage and the prevention of age-related cataracts
    David C Beebe
    Department of Ophthalmology and Visual Sciences, Washington University, Saint Louis, MO 63110, USA
    Ophthalmic Res 44:155-65. 2010
    ..Cataracts are often considered to be an unavoidable consequence of aging. Oxidative damage is a major cause or consequence of cortical and nuclear cataracts, the most common types of age-related cataracts...
  94. pmc Rapid assessment of avoidable blindness and needs assessment of cataract surgical services in Satkhira District, Bangladesh
    Z Wadud
    Child Sight Foundation, Dhaka, Bangladesh
    Br J Ophthalmol 90:1225-9. 2006
    To estimate the magnitude and causes of blindness in people aged > or =50 years in Satkhira district, Bangladesh, and to assess the availability of cataract surgical services.
  95. ncbi Eye fluke-induced cataract formation in fish: quantitative analysis using an ophthalmological microscope
    A Karvonen
    Department of Biological and Environmental Science, P O Box 35, FI 40014 University of Fyväskylä, Finland
    Parasitology 129:473-8. 2004
    We examined the parasite-induced cataract formation in rainbow trout (Oncorhynchus mykiss) using slit-lamp microscopy to determine the relationship between cataract intensity and number of Diplostomum spathaceum parasites that were ..
  96. ncbi Modern cataract surgery for radiation-induced cataracts in retinoblastoma
    Ihab M Osman
    Hopital Ophtalmique Jules Gonin, Lausanne, Switzerland
    Br J Ophthalmol 95:227-30. 2011
    ..This study analyses the safety and functional results of such surgery...
  97. pmc p21 both attenuates and drives senescence and aging in BubR1 progeroid mice
    Darren J Baker
    Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Cell Rep 3:1164-74. 2013
    ..here its antiaging effect is p21 independent, as we found p21 to promote senescence of lens epithelial cells and cataract formation...
  98. ncbi A new optical low coherence reflectometry device for ocular biometry in cataract patients
    P J Buckhurst
    Aston University, School of Life and Health Sciences, Ophthalmic Research Group, Aston Triangle, Birmingham, UK
    Br J Ophthalmol 93:949-53. 2009
    ..The study evaluates the validity and repeatability of these measurements compared with current clinical instrumentation...
  99. ncbi Poly(ADP-ribose)polymerase inhibition counteracts cataract formation and early retinal changes in streptozotocin-diabetic rats
    Viktor R Drel
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808, USA
    Invest Ophthalmol Vis Sci 50:1778-90. 2009
    ..This study evaluated the role for poly(ADP-ribose) polymerase (PARP) in diabetes-induced cataractogenesis and early retinal changes...
  100. ncbi Three and five year changes in intraocular pressures after clear corneal phacoemulsification in open angle glaucoma patients, glaucoma suspects, and normal patients
    Bradford J Shingleton
    Ophthalmic Consultants of Boston, Center for Eye Research and Education, Boston, MA, USA
    J Glaucoma 15:494-8. 2006
    ....
  101. pmc Deletion of autophagy-related 5 (Atg5) and Pik3c3 genes in the lens causes cataract independent of programmed organelle degradation
    Hideaki Morishita
    Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    J Biol Chem 288:11436-47. 2013
    ..However, deletion of Atg5 in the lens results in age-related cataract, which is accompanied by accumulation of polyubiquitinated and oxidized proteins, p62, and insoluble crystallins, ..

Research Grants73

  1. GENE MANIPULATION & H202 DEGRADATION IN THE OCULAR LENS
    Abraham Spector; Fiscal Year: 2001
    DESCRIPTION: Maturity onset cataract results in more than one million operations per year utilizing more than 12% of the Medicare budget...
  2. DIETARY & GENETIC CONTROL OF ROS DAMAGE TO THE LENS
    Norman S Wolf; Fiscal Year: 2010
    The studies proposed here follow 8 years of NEI supported work on the causes and mechanisms of age- related cataract (ARC)...
  3. Therapeutic Effect of a Novel Antioxidant on Degenerative Eye Disorders
    Nuran Ercal; Fiscal Year: 2012
    ..Preliminary animal studies have shown that intraperitoneal NACA reduces cataract formation while application of NACA to retinal epithelial cells prevents loss of cell viability...
  4. Suppression of Ocular Scarring - Controlled Delivery of an ALK-5 Inhibitor
    Hiroshi Nakamura; Fiscal Year: 2013
    ..g. endophthalmitis, 7.5% after GFS, than that after other ocular surgeries, e.g. 0.028-0.15% after cataract surgery (Wykoff et al, 2010;Freeman et al, 2010)...
  5. Vision Sciences Training Grant
    Carol A Mason; Fiscal Year: 2013
    ..the goals in NEI's long-standing plan for eye and vision research for retinal diseases, cornea, and lens and cataract programs, as well as the strabismus, amblyopia and visual processing...
  6. Environment, Novel Aging Outcomes, and Genetics
    Sung Kyun Park; Fiscal Year: 2013
    ..function, and two novel outcomes that have been relatively little studied in environmental health, age-related cataract and hearing loss...
  7. DEVELOPMENT AND MAINTENANCE OF LENS TRANSPARENCY
    JOHN IRWIN CLARK; Fiscal Year: 2013
    ..provides protection against protein unfolding, aggregation, and toxicity in aging disorders that include cataract, neurodegeneration, AMD, and possibly, neuromuscular disorders...
  8. VOLUME REGULATION IN NORMAL AND CATARACTOUS LENSES
    Richard T Mathias; Fiscal Year: 2013
    ..we began the process of putting together what we have learned to understand generation of the age-onset central cataract. Based on our findings, the overall hypothesis for this proposal is: The age-onset nuclear cataract is a ..
  9. 5500 Q-Trap Mass Spectrometer
    Stephen Barnes; Fiscal Year: 2010
    ..lung, mitochondrial-associated damage in models of oxidative stress (atherosclerosis, diabetes and cancer), lens cataract disease in aging, pathway robustness in the light of gene damage/loss, and in Cystic Fibrosis...
  10. PROTEIN KINASE C IN THE LENS
    DOLORES JEAN TAKEMOTO; Fiscal Year: 2010
    ..The long-term objective of this proposal is to determine how these stress switch PKC's protect the lens from cataract formation...
  11. Development of Small Heat Shock Proteins as Therapeutic Agents in the Eye
    JONATHAN MARK PETRASH; Fiscal Year: 2010
    ..phenotypic markers in a variety of disease models, including retinitis pigmentosa (RP) and aggregation-prone cataract mutants...
  12. Gene Regulation by and of LEDGF
    Dhirendra P Singh; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Environmental stress is a major cause of age related cataract (ARC). Acute or chronic stresses provoke multiple cellular reactions, including activation of the heat shock or stress protein response...
  13. Structural and Functional Changes in Myopia and Susceptibility to Glaucoma
    Lisa Ostrin; Fiscal Year: 2013
    ..Myopia is associated with retinal detachment, macular degeneration, cataract and glaucoma, with high myopia being one of the leading causes of blindness...
  14. Chinese American Eye Study
    Rohit Varma; Fiscal Year: 2013
    ..study we will determine cause-specific rates of blindness, visual impairment, and ocular disease (including cataract) in Chinese Americans aged 50 years and older...
  15. Ocular Oxygen Metabolism and the Etiology of Open Angle Glaucoma
    Carla J Siegfried; Fiscal Year: 2013
    ..for a longitudinal study in older Rhesus macaques that will sequentially undergo vitrectomy surgery and cataract extraction. We will map pO2 levels and measure aqueous humor antioxidants and outflow facility at each stage...
  16. AMINO-CARBONYL REACTIONS IN THE AGING HUMAN LENS
    Vincent M Monnier; Fiscal Year: 2013
    ..suggests oxidant stress from low glutathione (GSH) levels is important in the formation of age-related nuclear cataract (ARNC)...
  17. Membrane skeleton regulation of cell shape and interactions in lens development
    Velia M Fowler; Fiscal Year: 2013
    ..Mathias). These studies will establish basic mechanisms for gap junction control of lens transparency, and provide new insights for therapies in cataract prevention.
  18. Peroxiredoxin 6 and Cataractogenesis
    Dhirendra P Singh; Fiscal Year: 2010
    ..by applicant): Recent evidence implicates that the oxidative stress plays a role in the etiology of Age-Related Cataract, and suggests that aged lens cells are prone to this damage due to reduced expression of antioxidants...
  19. Unfolded Protein Response in Lens Epithelial Cells
    Toshimichi Shinohara; Fiscal Year: 2012
    ..Recently we showed that these drugs reduced ER stress, delayed LEC death, and alleviated cataract formation...
  20. Epidemiology of lens aging in older women
    JASON LEIGH SANDERS; Fiscal Year: 2013
    ..in early to mid adulthood and can be distinguished from known diseases of the lens, including specific types of cataract. The goal of this epidemiologic study is to determine the association of lens transparency with measures of ..
  21. Sensimmer Virtual Phaco Trainer for Cataract Surgery
    P Pat Banerjee; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): The SENSIMMER" Virtual Phaco Trainer for Cataract Surgery is a hardware and software solution aimed at a worldwide market of ophthalmology residency programs (including 118 programs in the US)...
  22. The Molecular Genetics of High Myopia
    Terri Lois Young; Fiscal Year: 2013
    ..Along with cataract, macular degeneration, infectious disease, and vitamin A deficiency, myopia is one of the most important causes ..
  23. EPR and Mossbauer Characterization of Mn and Fe Proteins, Models, Intermediates
    Michael P Hendrich; Fiscal Year: 2013
    ..metabolites of this pathway can lead to numerous physiological and pathological conditions, including: cataract formation, cerebral malaria, Alzheimer's disease, HIV infection, Huntington's disease and ischemic ..
  24. 11th International Symposium on the Maillard Reaction
    John W Baynes; Fiscal Year: 2012
    ..range of age-related chronic diseases, including arthritis, atherosclerosis, neurodegenerative disease, diabetes, cataract and macular degeneration...
  25. The Role of FGF Receptors in Lens Development
    Michael L Robinson; Fiscal Year: 2010
    ..This application is relevant to public health because cataract remains the most frequent worldwide cause of blindness and FGF/FGFR signaling plays an essential role in lens ..
  26. Variable Dose Rate X-ray Irradiator
    Howard B Lieberman; Fiscal Year: 2010
    ..molecular level, as well as specifically in relation to cancer of the brain, breast, ovary and/or prostate, and cataract formation...
  27. Cerebral Aneurysm Clipping Training Simulator using Virtual Reality and Haptics
    P Pat Banerjee; Fiscal Year: 2010
    ..g., acoustic neuromas). The Company is also active in ophthalmology, with a simulator for capsulorhexis during cataract surgery funded by NEI, and is working on open cholecystectomy...
  28. Asia-ARVO Travel Awards and Symposium
    Sally S Atherton; Fiscal Year: 2010
    ..of the United States National Institutes of Health (NIH), including: retinal diseases;corneal diseases;lens and cataract;glaucoma and optic neuropathies;strabismus, amblyopia, and visual processing;low vision and blindness ..
  29. Molecular characterization of congenital cataract
    Elena V Semina; Fiscal Year: 2013
    ..DO NOT EXCEED THE SPACE PROVIDED. Pediatric cataracts are observed in 1-15 per 10,000 births. Congenital cataract represents the most severe end of the spectrum due to interference with normal visual development and the ..
  30. Detoxification of Xenobiotics in Ocular Tissue
    YOGESH CHANDRA AWASTHI; Fiscal Year: 2010
    ..These studies would help in devising strategies to prevent/treat age-related degenerative ocular diseases such as cataract and ARMD.
  31. Effects of Long-Term Low Level Hydrogen Sulfide Exposure
    Michael N Bates; Fiscal Year: 2010
    ..of lung function testing by spirometry;and (5) the results of ocular and vision testing including examination for cataract and color vision impairment...
  32. Noninvasive Visualization and Analysis of Organ Systems using OCT and Digital Fun
    Steven J Pittler; Fiscal Year: 2010
    ..EY05922, Mechanisms of Ocular Development;and RO1 EY006400, Proteinase Inhibitors and Crystallin Fragments in Cataract)...
  33. ROLE OF TOXINS IN ENDOPHTHALMITIS
    MEREDITH GREGORY-KSANDER; Fiscal Year: 2012
    ..The numbers of cases, as well as the rate, has risen in recent years because of the increasing numbers of cataract surgery cases, increasing age of patients, and potentially increasing resistance of microbes to prophylactic ..
  34. ALDOSE REDUCTASE AND DIABETIC EYE DISEASE
    JONATHAN MARK PETRASH; Fiscal Year: 2013
    ..Aldose reductase (AR) has been implicated in the pathogenesis of diabetic cataract and retinopathy, but we do not understand the mechanism...
  35. Protein-thiol mixed disulfide in cataractogenesis
    Marjorie F Lou; Fiscal Year: 2013
    ..thioltransferase (TTase) and NADPH-dependent thioredoxin (TRx) protect against oxidative stress-induced cataract formation by their ability to repair oxidation damaged proteins and by their redox regulating functions of ..
  36. Smad3 inhibitors for ophthalmic applications
    Ching Yuan; Fiscal Year: 2010
    ..In addition, the anti-fibrosis potency of Smad3 inhibitors on lens and extraocular muscle injuries mimicking cataract and strabismus surgeries will be investigated in rabbits as well...
  37. The Role of Tdrd7 in Mammalian Lens Development
    Richard L Maas; Fiscal Year: 2013
    ..the molecular basis of tissue development, and it is also the target of the leading cause of blindness, cataract. During the prior grant period, we made major progress in elucidating the regulation of a key lens formation gene,..
  38. PROTEINS OF NORMAL AND CATARACTOUS LENSES
    FRANK JOSEPH GIBLIN; Fiscal Year: 2012
    ..of the proposed work is to better understand the role of oxidative stress in the development of human nuclear cataract, the most common type of lens opacity in older adults, and the type most likely to require surgery...
  39. Cloning zebrafish visual system mutants by whole-genome sequencing &SNP mapping
    Jeff Gross; Fiscal Year: 2013
    ..We will focus these further research efforts on the congenital cataract mutants...
  40. Transcriptional control of the mouse aA-crystallin locus
    Ales Cvekl; Fiscal Year: 2013
    ..Compromised lens transparency leads to cataract formation, a disease of the lens responsible for nearly half of the cases of blindness worldwide...
  41. Role and Molecular Mechanisms of Corneal Aldehyde Dehydrogenase
    Vasilis Vasiliou; Fiscal Year: 2013
    ..ALDH3A1 and ALDH1A1 detoxify 4-HNE, which has been implicated in the pathogenesis of several diseases including cataract and degenerative retinal disease...
  42. Therapeutic Effects of Cataract Removal in Alzheimer's Disease
    GROVER CLEVELAND GILMORE; Fiscal Year: 2013
    ..However, the value of cataract removal in patients already affected with AD is uncertain, and many ophthalmologists, geriatricians, and care-..
  43. Mechanisms of lens growth regulation
    Xiaohua Gong; Fiscal Year: 2013
    ..into interior metabolically inactive fibers, which likely impedes lens homeostasis to contribute to age-related cataract. It is unknown why lens equatorial epithelial cells continue to proliferate and differentiate into elongating ..
  44. Toll-like receptors and bacterial endophthalmitis
    Ashok Kumar; Fiscal Year: 2013
    ..endophthalmitis is a vision-threatening complication of penetrating eye injury and intraocular surgery, notably cataract surgery, the most common ophthalmic procedure performed in older populations in the United States...
  45. Development of a Biomimetic Vitreous Substitute
    Nathan Ravi; Fiscal Year: 2013
    ..Surgical complications include development of nuclear cataract, glaucoma, corneal decompensation, and retinal re-detachments...
  46. THE ROLE OF AQUAPORIN-0 IN LENS DEVELOPMENT AND AGING
    Kevin L Schey; Fiscal Year: 2013
    ..We propose three aims: 1) to spatially map the age- and cataract-related changes to the human lens membrane proteome, 2) to determine the role of AQP0 in lens cell morphology and ..
  47. MAILLARD REACTIONS AND OXIDATION IN CATARACTOGENESIS
    Ram H Nagaraj; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Lens proteins undergo numerous physico-chemical changes during aging and cataract formation;pigmentation and crosslinking are the two major ones...
  48. Micro Patterned Intraocular Lens Membrane for Reducing Incidence of PCO
    SHRAVANTHI REDDY; Fiscal Year: 2013
    ..S. has at least tripled cataract surgeries in just two decades...
  49. Longevity genes and calorie restriction: early post-natal effects
    Andrzej Bartke; Fiscal Year: 2013
    ..traits related to health span, including indices of immune function, locomotion, stress resistance, and cataract development...
  50. The role of DNA methylation in lens fiber cell terminal differentiation
    Rachel K Tittle; Fiscal Year: 2012
    ..This topic has relevance as a mechanism for understanding cataract formation, and it will increase our understanding of how deregulated DNA methylation can contribute to cancer...
  51. Identification of quantitative ocular trait genes in the Beaver Dam Eye
    Alison P Klein; Fiscal Year: 2013
    ..The leading causes of visual impairment are cataract, glaucoma, uncorrected refractive errors, diabetic retinopathy and age-related macular degeneration...
  52. Ocular Drug Delivery Devices for Improved Postoperative Cataract Care
    Buddy D Ratner; Fiscal Year: 2010
    ..Extracapsular cataract surgery (ECCS) is the most common ophthalmologic procedure performed worldwide;during this procedure the old lens ..
  53. MRI Biometry of the Pseudophakic Cadaver Eye
    Susan A Strenk; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Cataract surgery is a common procedure that results in removal of the human lens and its replacement with an intraocular lens (IOL). It is a safe procedure, but complications do occur...
  54. Caloric Restriction and Aging in Eyes
    Peter Gouras; Fiscal Year: 2010
    ..examinations whether CR retards the development of aging and age related ocular disease (macular degeneration, cataract, glaucoma, optic nerve atrophy) in these monkeys...
  55. Lens intercellular communication connexins and cataract
    Thomas W White; Fiscal Year: 2013
    ..communication is important in the development and maintenance of lens, as mutations in lens connexin genes cause cataract and developmental defects in humans and mice...
  56. SENSIMMER? Virtual Phaco Trainer for Cataract Surgery
    P Banerjee; Fiscal Year: 2009
    ..University of Illinois at Chicago, the Partnership proposes to develop and commercialize its training modules for cataract surgery...
  57. University of Miami Vision Loss Prevention Translational Research Center
    David J Lee; Fiscal Year: 2013
    ..patterns for patients with the following disabling ocular conditions: age-related macular degeneration (AMD), cataract, diabetic retinopathy, and open-angle glaucoma, as a function of insurance status, insurance type, ocular ..
  58. Ocular and Health Trajectories: The SEE Study
    David J Lee; Fiscal Year: 2012
    ..It will also determine if improvements in visual functioning due to either treatment (e.g., cataract surgery) and/or improvements in lifestyle (e.g...
  59. FIBER CELL JUNCTIONS IN NORMAL AND CATARACTOUS LENSES
    M Joseph Costello; Fiscal Year: 2011
    ..is a request to support further analysis of human age-related nuclear cataracts, the most common form of human cataract that causes visual decline and worldwide blindness...
  60. INTERCELLULAR COMMUNICATION IN THE LENS
    Lisa Ebihara; Fiscal Year: 2013
    ..In addition, the functional and cellular effects of several congenital cataract associated connexin mutations that localize to the N- terminal and E1 domains will be tested. Aim 2...
  61. Partitioning of Misfolded Membrane Proteins Between Different Degradatory Fates
    SCOTT ANDREW HOUCK; Fiscal Year: 2013
    ..in number of diseases, including the age-related diseases Alzheimer's disease, Parkinson's disease, and cataract. Cellular factors, including molecular chaperones and E3 ubiquitin ligases, recognize misfolded proteins and ..
  62. Guiding the Treatment of Anterior Eye Disease with Optical Coherence Tomography
    David Huang; Fiscal Year: 2013
    ..Currently, surgeons lack an accurate way to calculate precise intraocular lens (IOL) power for cataract patients who previously had laser vision correction...
  63. The Regulation of Lens Fiber Cell Differentiation
    Melinda K Duncan; Fiscal Year: 2012
    The underlying pathology of cataract can often be demonstrated to involve defects in the differentiation of lens fiber cells from their proliferative transitional zone precursors...
  64. A DATABASE OF IOL POSITION AND BEHAVIOR
    Susan A Strenk; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Cataract surgery is a common procedure that results in removal of the human lens and its replacement with an intraocular lens (IOL). It is a safe procedure, but complications do occur...
  65. ATP LINKED EFFECTORS OF NA+, K+ ATPASE AND CATARACTS
    MARGARET GARNER; Fiscal Year: 2001
    ..role of the lens Na,K-ATPases and their ATP-linked effectors (H+, Na+, K+, ATP, ADP, and digitalis alkaloids) in cataract formation...
  66. RANDOMIZED TRIALS OF VITAMIN SUPPLEMENTS AND EYE DISEASE
    William Christen; Fiscal Year: 2002
    ..that supplementation with antioxidant vitamins reduces the risk of age-related macular degeneration (AMD) and cataract. This proposal includes continuation of current ongoing investigations conducted as part of the Physicians' ..
  67. APOPTOSIS--LENS DIFFERENTIATION AND CATARACT DEVELOPMENT
    David Li; Fiscal Year: 2000
    ..However, the common cellular mechanism by which these different agents cause cataract has remained unknown...
  68. MECHANISM OF SELENIUM INDUCED CATARACT
    Thomas Shearer; Fiscal Year: 2002
    The overall goal of this project has been to provide a biochemical mechanism for formation of selenite cataract in young rats...
  69. Treatment for Canine Diabetic Cataracts
    Milton Wyman; Fiscal Year: 2007
    ..aldose reductase initiates sugar cataracts in both diabetic and galactosemic animals and that ARIs prevent sugar cataract formation in both of these animal models...
  70. BARBADOS INCIDENCE STUDY OF EYE DISEASES II
    M Leske; Fiscal Year: 2001
    ..II (BISED II) aims to collect 9-year incidence and progression data on open-angle glaucoma (OAG) and age-related cataract in the predominantly black population of Barbados, West Indies, as well as to obtain natural history data on age- ..
  71. IN VIVO ANALYSIS OF CORNEAL ENDOTHELIAL WOUND HEALING
    W Petroll; Fiscal Year: 1991
    b>Cataract extraction with intraocular lens placement has the potential to injure the endothelium of more than 1 million patients annually in the U.S...
  72. CALCIUM AND THE NORMAL LENS AND CATARACT
    George Duncan; Fiscal Year: 2000
    DESCRIPTION: Cataract and posterior capsule opacification (PCO) are major drains on health budgets throughout the world and it is a long-term objective of this project to develop strategies to prevent both of these conditions...
  73. MOLECULAR BIOLOGY OF DIABETIC CATARACT FORMATION
    PATRICK CAMMARATA; Fiscal Year: 2004
    DESCRIPTION (Adapted from applicant's abstract): Diabetic cataract is a significant and costly worldwide health problem. Intracellular osmotic stress has been implicated in the etiology of diabetic cataract...