blepharoptosis

Summary

Summary: Drooping of the upper lid due to deficient development or paralysis of the levator palpebrae muscle.

Top Publications

  1. ncbi Comparison of silastic and banked fascia lata in pediatric frontalis suspension
    Dov Hersh
    Department of Pediatric Ophthalmology Childrens Hospital at Westmead, Sydney, Australia
    J Pediatr Ophthalmol Strabismus 43:212-8. 2006
  2. ncbi Modified technique and ptosis clamp for surgical correction of congenital pediatric ptosis by anterior levator resection
    Kayvan Keyhani
    Department of Ophthalmology, The New York Eye and Ear Infirmary, New York, New York, USA
    Facial Plast Surg 23:156-61. 2007
  3. ncbi Frontalis suspension with fascia lata for severe congenital blepharoptosis using enhanced involuntary reflex contraction of the frontalis muscle
    Kiyoshi Matsuo
    Department of Plastic and Reconstructive Surgery, Shinshu University School of Medicine and Graduate School of Medicine, 3 1 1 Asahi, Matsumoto, Nagano 390 8621, Japan
    J Plast Reconstr Aesthet Surg 62:480-7. 2009
  4. ncbi Spectrum of FOXL2 gene mutations in blepharophimosis-ptosis-epicanthus inversus (BPES) families demonstrates a genotype--phenotype correlation
    E De Baere
    Department of Medical Genetics, Ghent University Hospital, B 9000 Ghent, Belgium
    Hum Mol Genet 10:1591-600. 2001
  5. ncbi The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis/ptosis/epicanthus inversus syndrome
    L Crisponi
    Istituto di Ricerca sulle Talassemie ed Anemie Mediterranee CNR, and Dipartimento di Scienze Biomediche e Biotecnologie, Ospedale Regionale per le Microcitemie, Universita degli Studi di Cagliari, Cagliari, Italy
    Nat Genet 27:159-66. 2001
  6. ncbi Isolated unilateral neurogenic blepharoptosis secondary to eyelid trauma
    Timothy J McCulley
    Department of Ophthalmology, University of Cincinnati, and the Cincinnati Eye Institute, Ohio, USA
    Am J Ophthalmol 134:626-7. 2002
  7. ncbi Mutations in FOXL2 underlying BPES (types 1 and 2) in Colombian families
    J L Ramirez-Castro
    Unidad de Genética Médica, Facultad de Medicina, Universidad de Antioquia, Medellin, Colombia
    Am J Med Genet 113:47-51. 2002
  8. ncbi Comparative analysis of the FOXL2 gene and characterization of mutations in BPES patients
    Nitin Udar
    Jules Stein Eye Institute, University of California, Los Angeles, California 90095, USA
    Hum Mutat 22:222-8. 2003
  9. ncbi Not only hard contact lens wear but also soft contact lens wear may be associated with blepharoptosis
    Isabel Bleyen
    Department of Ophthalmology, Erasmus MC University Hospital, Rotterdam, The Netherlands
    Can J Ophthalmol 46:333-6. 2011
  10. ncbi Classification and surgical management of patients with familial and sporadic forms of congenital fibrosis of the extraocular muscles
    Ahmad Yazdani
    Department of Pediatric Ophthalmology and Strabismus and Center for Genetic Eye Diseases, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Ophthalmology 111:1035-42. 2004

Research Grants

  1. Pathogenesis of a Novel Limb-Girdle Muscular Dystrophy
    Michio Hirano; Fiscal Year: 2003
  2. Prednisone Ocular Myasthenia Gravis Trial Planning Grant
    Mark Kupersmith; Fiscal Year: 2004
  3. GENETICS OF PARKINSON DISEASE IN THE AMISH
    Brad Racette; Fiscal Year: 2006
  4. Epidemilogy of Parkinsonism in Welders
    Brad A Racette; Fiscal Year: 2011

Detail Information

Publications244 found, 100 shown here

  1. ncbi Comparison of silastic and banked fascia lata in pediatric frontalis suspension
    Dov Hersh
    Department of Pediatric Ophthalmology Childrens Hospital at Westmead, Sydney, Australia
    J Pediatr Ophthalmol Strabismus 43:212-8. 2006
    ..To compare the use of Silastic and banked fascia lata in pediatric frontalis suspension surgery for functional success, ptosis recurrence, and infection and granuloma rates...
  2. ncbi Modified technique and ptosis clamp for surgical correction of congenital pediatric ptosis by anterior levator resection
    Kayvan Keyhani
    Department of Ophthalmology, The New York Eye and Ear Infirmary, New York, New York, USA
    Facial Plast Surg 23:156-61. 2007
    ..The author has utilized this clamp and modified technique in over 350 lid surgeries over the past ten years...
  3. ncbi Frontalis suspension with fascia lata for severe congenital blepharoptosis using enhanced involuntary reflex contraction of the frontalis muscle
    Kiyoshi Matsuo
    Department of Plastic and Reconstructive Surgery, Shinshu University School of Medicine and Graduate School of Medicine, 3 1 1 Asahi, Matsumoto, Nagano 390 8621, Japan
    J Plast Reconstr Aesthet Surg 62:480-7. 2009
    ..this neurophysiological mechanism during surgery on 50 patients with severe unilateral or bilateral congenital blepharoptosis that does not have the levator muscle but has Mueller's muscle...
  4. ncbi Spectrum of FOXL2 gene mutations in blepharophimosis-ptosis-epicanthus inversus (BPES) families demonstrates a genotype--phenotype correlation
    E De Baere
    Department of Medical Genetics, Ghent University Hospital, B 9000 Ghent, Belgium
    Hum Mol Genet 10:1591-600. 2001
    ..Furthermore, we propose that in a fraction of the BPES patients the genetic defect does not reside within the coding region of the FOXL2 gene and may be caused by a position effect...
  5. ncbi The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis/ptosis/epicanthus inversus syndrome
    L Crisponi
    Istituto di Ricerca sulle Talassemie ed Anemie Mediterranee CNR, and Dipartimento di Scienze Biomediche e Biotecnologie, Ospedale Regionale per le Microcitemie, Universita degli Studi di Cagliari, Cagliari, Italy
    Nat Genet 27:159-66. 2001
    ..FOXL2 represents a candidate gene for the polled/intersex syndrome XX sex-reversal goat...
  6. ncbi Isolated unilateral neurogenic blepharoptosis secondary to eyelid trauma
    Timothy J McCulley
    Department of Ophthalmology, University of Cincinnati, and the Cincinnati Eye Institute, Ohio, USA
    Am J Ophthalmol 134:626-7. 2002
    To describe eyelid trauma as a cause of isolated neurogenic blepharoptosis.
  7. ncbi Mutations in FOXL2 underlying BPES (types 1 and 2) in Colombian families
    J L Ramirez-Castro
    Unidad de Genética Médica, Facultad de Medicina, Universidad de Antioquia, Medellin, Colombia
    Am J Med Genet 113:47-51. 2002
    ....
  8. ncbi Comparative analysis of the FOXL2 gene and characterization of mutations in BPES patients
    Nitin Udar
    Jules Stein Eye Institute, University of California, Los Angeles, California 90095, USA
    Hum Mutat 22:222-8. 2003
    ..548A>G (H104R); g.652G>T (E139X); and g.1178_1185del8 (A314fsX530). In addition we also identified two known mutations g.823C>T (Q196X) and g.1092_1108dup17, the latter in individuals from three unrelated pedigrees...
  9. ncbi Not only hard contact lens wear but also soft contact lens wear may be associated with blepharoptosis
    Isabel Bleyen
    Department of Ophthalmology, Erasmus MC University Hospital, Rotterdam, The Netherlands
    Can J Ophthalmol 46:333-6. 2011
    ..The authors attempt to establish an association between prolonged hard and soft contact lens wear and ptosis...
  10. ncbi Classification and surgical management of patients with familial and sporadic forms of congenital fibrosis of the extraocular muscles
    Ahmad Yazdani
    Department of Pediatric Ophthalmology and Strabismus and Center for Genetic Eye Diseases, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Ophthalmology 111:1035-42. 2004
    ....
  11. ncbi Novel and recurrent KIF21A mutations in congenital fibrosis of the extraocular muscles type 1 and 3
    Shasha Lu
    Department of Molecular Medicine and Surgery, Karolinska Institute, Karolinska University Hospital Solna, Stockholm, Sweden
    Arch Ophthalmol 126:388-94. 2008
    ..To characterize the disease-causing mutations and associated clinical phenotypes in 5 Chinese families with congenital fibrosis of the extraocular muscles (CFEOM)...
  12. doi Blepharophimosis, blepharoptosis, defects of the anterior chamber of the eye, caudal appendage, radioulnar synostosis, hearing loss and umbilical anomalies in sibs: 3MC syndrome?
    Gabriela F Leal
    Servico de Genetica Medica, Instituto Materno Infantil Prof Fernando Figueira, Recife PE, Brazil
    Am J Med Genet A 146:1059-62. 2008
  13. ncbi Sporadic and familial blepharophimosis -ptosis-epicanthus inversus syndrome: FOXL2 mutation screen and MRI study of the superior levator eyelid muscle
    H Dollfus
    LGME du CNRS, U 184 INSERM, Faculte de Medecine, Clinique Ophtalmologique and Département de Radiologie, Hopitaux Universitaires de Strasbourg, Strasbourg, France
    Clin Genet 63:117-20. 2003
    ..Magnetic Resonance Imaging (MRI) of the orbit, in one family, showed absence or hypotrophy of the eyelid superior levator muscle suggesting a possible role of FOXL2 in the development of this extra-ocular muscle...
  14. ncbi Blepharoptosis: evaluation, techniques, and complications
    Syed M Ahmad
    Department of Ophthalmology, St Luke s Roosevelt Hospital Center, New York, New York, USA
    Facial Plast Surg 23:203-15. 2007
    b>Blepharoptosis (ptosis) is one of the most common eyelid disorders encountered in ophthalmology. A detailed history and exam are crucial in the evaluation of a patient presenting with ptosis...
  15. ncbi One medial triangular Tutoplast sling as a frontalis suspension for adult myogenic blepharoptosis
    Nir Seider
    Alberto Moscona Department of Ophthalmology, Rambam Medical Centre, Haifa, Israel
    Acta Ophthalmol Scand 84:121-3. 2006
    The treatment of choice for medium to severe blepharoptosis with minimal or no levator function is frontalis suspension with a sling, using a rectangular or rhomboid sling placement technique...
  16. ncbi Mutation analysis of the FOXL2 gene in Chinese patients with blepharophimosis-ptosis-epicanthus inversus syndrome
    Shengjian Tang
    Plastic and Reconstructive Research Institute, Weifang Medical College, Weifang 261042, Shandong Province, Peoples Republic of China
    Mutagenesis 21:35-9. 2006
    ..So we speculate that in a fraction of the BPES patients the genetic defect may represent a change in gene dosage or a rearrangement outside the transcription unit of FOXL2...
  17. ncbi Congenital ptosis: Long-term outcome of frontalis suspension using autogenous temporal fascia or fascia lata in children
    C Philandrianos
    Service de Chirurgie Plastique Pédiatrique, Department of Pediatric Plastic Surgery, Hôpital Timone Enfants Timone Children s Hospital, 264 rue Saint Pierre, 13385 Marseille Cedex 05, France
    J Plast Reconstr Aesthet Surg 63:782-6. 2010
    Children with severe congenital blepharoptosis are at risk of developing amblyopia. For this reason, ptosis repair is indicated as soon as the diagnosis is made...
  18. ncbi Three novel FOXL2 gene mutations in Chinese patients with blepharophimosis-ptosis-epicanthus inversus syndrome
    Siu fong June Or
    Clinical Genetic Service, Department of Health, Hong Kong SAR, China
    Chin Med J (Engl) 119:49-52. 2006
  19. ncbi Surgical treatment of blepharoptosis caused by chronic progressive external ophthalmoplegia
    Kazutaka Soejima
    Department of Plastic Surgery, Tokyo Metropolitan Hiroo General Hospital, Tokyo, Japan
    Ann Plast Surg 56:439-42. 2006
    ..disorder characterized by progressive weakness of the extraocular and levator muscles, which causes blepharoptosis and impairment of ocular motility...
  20. ncbi Blepharoptosis surgery complicated by late suture migration
    J A Foster
    Department of Ophthalmic Plastic and Reconstructive Surgery, Cole Eye Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Ophthalmol 130:116-7. 2000
    To report late suture migration as a complication of blepharoptosis surgery.
  21. ncbi Mersilene mesh sling as an alternative to autogenous fascia lata in the management of ptosis
    E El-Toukhy
    Department of Ophthalmology, Faculty of Medicine, Cairo University, Egypt
    Eye (Lond) 15:178-82. 2001
    ..To evaluate the use of Mersilene mesh as a brow suspensory material and to compare it clinically against autogenous fascia lata...
  22. ncbi Topical naphazoline in the treatment of myasthenic blepharoptosis
    Yuriko Nagane
    Department of Neurology, Hanamaki General Hospital, 4 28 Kajoh chou, Hanamaki 025 0075, Japan
    Muscle Nerve 44:41-4. 2011
    ..We examined the efficacy of topical naphazoline in the treatment of myasthenic blepharoptosis.
  23. ncbi Frontalis suspension sling using a silicone rod in patients affected by myogenic blepharoptosis
    Francesco P Bernardini
    Clinica Oculistica, Universita di Genova, Genova, Italy
    Orbit 21:195-8. 2002
    ..A silicone rod, because of its elasticity, is the material of choice in this selected category of patients...
  24. ncbi Blepharoptosis in RGP and PMMA hard contact lens wearers
    Janice H J Thean
    Royal Victorian Eye and Ear Hospital, Melbourne, Australia
    Clin Exp Optom 87:11-4. 2004
    Contact lens wear has been documented to cause an acquired non-senile blepharoptosis. This is generally associated with prolonged wearing of hard contact lenses...
  25. ncbi Upgaze eyelid position allows differentiation between congenital and aponeurotic blepharoptosis according to the neurophysiology of eyelid retraction
    Chihiro Hirasawa
    Department of Plastic and Reconstructive Surgery, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
    Ann Plast Surg 57:529-34. 2006
    To differentiate between congenital and aponeurotic blepharoptosis, we investigated whether upgaze with stretching of the mechanoreceptor of Mueller muscle increases involuntary reflex contraction of the levator slow-twitch muscle fibers...
  26. ncbi Long-term outcome of strabismus and ptosis surgery in a mother and daughter with congenital fibrosis of extraocular muscles
    Branislav Stanković
    Clinical Center of Serbia, Institute of Ophthalmology, Belgrade, Serbia
    Vojnosanit Pregl 63:835-8. 2006
    ..The aim of this report was to describe a severe, atypical, exposure-induced corneal stromal lysis in two patients...
  27. ncbi Surgical desensitisation of the mechanoreceptors in Müller's muscle relieves chronic tension-type headache caused by tonic reflexive contraction of the occipitofrontalis muscle in patients with aponeurotic blepharoptosis
    Kiyoshi Matsuo
    Department of Plastic and Reconstructive Surgery, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
    J Plast Surg Hand Surg 47:21-9. 2013
    ..In aponeurotic blepharoptosis, since the levator aponeurosis is disinserted from the tarsus, stretching of the mechanoreceptors in Müller's ..
  28. ncbi 'Kite-tail' fascia lata strips technique: frontalis suspension using a non-endoscopic minimally invasive single-thigh incision approach
    Cem Evereklioglu
    Department of Ophthalmology, Division of Oculoplastic, Orbital and Lacrimal Surgery, Erciyes University Medical Faculty, Kayseri, Turkey
    Br J Ophthalmol 96:570-5. 2012
    To introduce 'kite-tail' strips or a 'multiple Z-plasty' technique on an autogenous fascia lata graft without a stripper to correct severe blepharoptosis by frontalis suspension and to evaluate its effectiveness on surgical outcome.
  29. ncbi A novel mutation in the FOXL2 gene in a patient with blepharophimosis syndrome: differential role of the polyalanine tract in the development of the ovary and the eyelid
    Kenjiro Kosaki
    Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan
    Ophthalmic Genet 23:43-7. 2002
    ..We suggest that the polyalanine tract may have a differential role in eyelid and ovarian development and function. Further work is required to clarify whether ovarian function can be predicted on the basis of genotype...
  30. ncbi Open loop fascial sling for severe congenital blepharoptosis
    Zakaria Yahya Arajy
    Scientific Council of Plastic Surgery, Iraqi Board for Medical Specializations, Baghdad, Iraq
    J Craniomaxillofac Surg 40:129-33. 2012
    ..We describe a simple open loop fascia lata suspension sling to the frontalis muscle to treat patients with severe eyelid ptosis and poor levator function...
  31. ncbi Frontalis suspension technique with a temporal-fasciae-complex sheet for repairing blepharoptosis
    J Fan
    Mid-2 Division of Plastic Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Beijing, PR China
    Aesthetic Plast Surg 25:147-51. 2001
    Congenital blepharoptosis presents as a drooping upper eyelid with an unpleasant appearance. Severe blepharoptosis usually has to be treated with varying modifications of frontalis suspension techniques...
  32. ncbi Mini-invasive ptosis surgery
    Francesco P Bernardini
    Ospedale Evangelico Internazionale, Genova and Ospedale Evangelico Valdese, Torino, Italy
    Orbit 25:111-5. 2006
    ..We believe that, in a selected group of patients, a less invasive approach with an upper lid skin incision of only 0.8 cm is equally effective for the final result and offers several advantages compared to the traditional technique...
  33. ncbi Double-eyelid blepharoplasty incorporating blepharoptosis surgery for 'latent' aponeurotic ptosis
    Jin Li
    Department of Ophthalmology, Ninth People s Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, PR China
    J Plast Reconstr Aesthet Surg 64:993-9. 2011
    ..Incorporation of the aponeurotic reinsertion and minimal dissection into the blepharoptosis surgery will correct the 'latent' aponeurotic ptosis successfully.
  34. ncbi Blepharoptosis repaired by frontalis-orbicularis oculi flap: a new technique
    Keerapat Bhiromekraibhak
    Plastic and Reconstructive Division, Department of Surgery, Faculty of Medicine, Panyananthaphikkhu Chonprathan Medical Center, Srinakharinwirot University, Nonthaburi, Thailand
    J Med Assoc Thai 93:S15-20. 2010
    The treatment of blepharoptosis depends on the degree of ptosis and the function of the levator muscle...
  35. ncbi Unilateral eyelid angiofibroma with complete blepharoptosis as the presenting sign of tuberous sclerosis
    Juan Pablo Lopez
    Department of Ophthalmology, Clinica Alemana de Santiago and Universidad Del Desarrollo, Santiago, Chile
    J AAPOS 13:413-4. 2009
    ..We report a case of a newborn with congenital eyelid angiofibroma mimicking complete congenital blepharoptosis that was revealed by central nervous system imaging to be part of the tuberous sclerosis complex.
  36. ncbi Paediatric blepharoptosis: a 10-year review
    A Berry-Brincat
    Eye Department Birmingham Children s Hospital, Birmingham, UK
    Eye (Lond) 23:1554-9. 2009
    To examine the characteristics of blepharoptosis and the success of surgical intervention in a large group of children presenting to a specialist at paediatric ophthalmology center.
  37. ncbi Diplopia, blepharoptosis, and ophthalmoplegia and 3-hydroxy-3-methyl-glutaryl-CoA reductase inhibitor use
    F W Fraunfelder
    Casey Eye Institute, Department of Ophthalmology, Oregon Health and Science University, Portland, Oregon 97239 4197, USA
    Ophthalmology 115:2282-5. 2008
    To report the association between 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase inhibitors (statins) and diplopia, blepharoptosis (ptosis), and ophthalmoplegia.
  38. ncbi Prediction of postoperative eyelid height after frontalis suspension using autogenous fascia lata for pediatric congenital ptosis
    Chang Yeom Kim
    The Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea
    Am J Ophthalmol 153:334-342.e2. 2012
    ..To predict eyelid height after frontalis suspension using autogenous fascia lata for congenital ptosis...
  39. ncbi [Bilateral primary pseudotumoral palpebral amyloidosis. A case report]
    M Lezrek
    Service d Ophtalmologie A, Hopital des specialites, Rabat, Morocco
    J Fr Ophtalmol 30:e17. 2007
    ..Clinical progression showed improvement of the ptosis and the patient's comfort. Although rare, palpebral amyloidosis poses management problems, particularly in advanced cases, because of corneal complications and recurrence...
  40. pmc Efficacy and efficiency of a new involutional ptosis correction procedure compared to a traditional aponeurotic approach
    Bartley R Frueh
    Department of Ophthalmology and Visual Sciences, W K Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan, USA
    Trans Am Ophthalmol Soc 102:199-206; discussion 206-7. 2004
    ..This was a retrospective study to compare the efficacy and efficiency of a new small anterior incision, minimal dissection ptosis procedure with that of a traditional anterior aponeurotic approach for the correction of aponeurotic ptosis...
  41. ncbi Primary bilateral silicone frontalis suspension for good levator function ptosis in oculopharyngeal muscular dystrophy
    Richard C Allen
    Department of Surgery, Division of Ophthalmology, University of New Mexico School of Medicine, Albuquerque, New Mexico USA
    Br J Ophthalmol 96:841-5. 2012
    ..To evaluate outcomes of patients with oculopharyngeal muscular dystrophy (OPMD) with levator function (LF) ≥ 10mm who underwent primary bilateral silicone frontalis suspension...
  42. ncbi Correction of congenital severe ptosis by suspension of a frontal muscle flap overlapped with an inferiorly based orbital septum flap
    Y Pan
    Department of Plastic Surgery, Xijing Hospital, Xi an, People s Republic of China
    Aesthetic Plast Surg 32:604-12; discussion 613. 2008
    ..This report introduces a new method for correction of congenital severe upper eyelid ptosis...
  43. ncbi Ptosis repair options and algorithm
    Altug Cetinkaya
    Department of Ophthalmology, University of Cincinnati, Cincinnati, Ohio, USA
    Curr Opin Ophthalmol 19:428-34. 2008
    ..Each patient needs to be individually assessed and treated. A surgeon needs to be familiar with all types of surgical repair to choose the best possible option for his/her particular patient...
  44. ncbi Blepharoptosis and external ophthalmoplegia associated with long-term antiretroviral therapy
    Warren L Dinges
    Department of Internal Medicine, Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390 9103, USA
    Clin Infect Dis 47:845-52. 2008
    ..b>Blepharoptosis, without prior ART association, is usually caused by age-associated involutional ptosis, but it is also seen ..
  45. ncbi Frontalis slings with palmaris tendon as an adjuvant treatment for myasthenic blepharoptosis: a case report
    Chien Chih Yu
    Division of Plastic Surgery, Department of Surgery, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    Ann Plast Surg 58:577-9. 2007
    ..The surgical result has been stable for more than 2 years. For patients who have failed to respond to medical therapy for MG, frontalis sling procedure is an appropriate adjuvant treatment option...
  46. ncbi Aesthetic blepharoptosis correction with release of fibrous web bands between the levator aponeurosis and orbital fat
    Joo Hyoung Kim
    Department of Plastic and Reconstructive Surgery, Ajou University Hospital, Suwon, Korea
    J Craniofac Surg 23:e52-5. 2012
    ..To correct these features, an accurate understanding of upper eyelid anatomy is essential, especially concerning the levator aponeurosis, orbital fat, and orbital septum...
  47. pmc Aetiology and surgical treatment of childhood blepharoptosis
    V Lee
    Oculoplastic Service, Moorfields Eye Hospital, London, UK
    Br J Ophthalmol 86:1282-6. 2002
    ..To describe the aetiology, demography, surgical management, and outcome of a cohort of paediatric ptosis patients in a large tertiary referral oculoplastic centre...
  48. ncbi Periocular and orbital amyloidosis: clinical characteristics, management, and outcome
    Igal Leibovitch
    Oculoplastic and Orbital Division, Department of Ophthalmology and Visual Sciences, Royal Adelaide Hospital, University of Adelaide, Adelaide, Australia
    Ophthalmology 113:1657-64. 2006
    ..To present the clinical features and management outcome in a large series of patients with periocular and orbital amyloidosis...
  49. ncbi Ptosis from localized A-lambda-amyloid deposits in the levator palpebrae muscle
    Stefan Dithmar
    Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany
    Ophthalmology 111:1043-7. 2004
    ..To describe a patient with unilateral ptosis caused by localized amyloid deposits of immunoglobulin lambda-light chains (A-lambda-amyloid) in the levator palpebrae muscle...
  50. ncbi Mapping a gene for congenital fibrosis of the extraocular muscles to the centromeric region of chromosome 12
    E C Engle
    Department of Neurology, Howard Hughes Medical Institute, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115
    Nat Genet 7:69-73. 1994
    ..9 (theta = 0.03) and 5.4 (theta = 0.03) respectively, defining a region of 8 cM. These data establish a map location for CFEOM and demonstrate that this may be a genetically homogeneous disorder...
  51. ncbi A simplified technique of ptosis repair using a single adjustable suture
    M A Meltzer
    Department of Ophthalmology, Mount Sinai School of Medicine, New York, New York, USA
    Ophthalmology 108:1889-92. 2001
    ..It is also useful when the "ideal" lid level may not be determined until the postoperative period, such as eyes subject to ptosis by Hering's law, levator dehiscence, or those at increased potential risk for corneal exposure...
  52. ncbi Advances in the diagnosis and treatment of ptosis
    Michael Baroody
    Danbury Hospital, Danbury, Connecticut, USA
    Curr Opin Ophthalmol 16:351-5. 2005
    The surgical correction of blepharoptosis, both congenital and acquired, has been intensively examined and reported on for many years...
  53. ncbi Frontalis muscle advancement: a dynamic structure for the treatment of severe congenital eyelid ptosis
    Oscar M Ramirez
    Johns Hopkins University and University of Maryland School of Medicine, Baltimore, MD, USA
    Plast Reconstr Surg 113:1841-9; discussion 1850-1. 2004
    ..Symmetry is created by intervention on the contralateral eyelid to provide symmetrical supratarsal creases...
  54. ncbi FOXL2-mutations in blepharophimosis-ptosis-epicanthus inversus syndrome (BPES); challenges for genetic counseling in female patients
    Siv Fokstuen
    Division of Medical Genetics, University of Geneva Medical School and University Hospitals, Geneva, Switzerland
    Am J Med Genet A 117:143-6. 2003
    ..As a consequence, FOXL2 mutation testing in female patients of child-bearing age with BPES should be handled with caution, and a two-step genetic counseling approach, including an initial pre-test information session, is proposed...
  55. ncbi Major review: the clinical spectrum of pediatric myasthenia gravis: blepharoptosis, ophthalmoplegia and strabismus. A report of 14 cases
    Kathryn M B McCreery
    Department of Ophthalmology, Baylor College of Medicine, Texas Children s Hospital, Houston, Texas 77030, USA
    Binocul Vis Strabismus Q 17:181-6. 2002
    ..The purpose of this study is to evaluate the clinical spectrum of this condition in children and to identify factors that may aid the clinician in its diagnosis and management...
  56. ncbi Neurological features of congenital fibrosis of the extraocular muscles type 2 with mutations in PHOX2A
    Thomas M Bosley
    Neuro Ophthalmology Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    Brain 129:2363-74. 2006
    ..Clinical presentation, neuroimaging and Phox2a-/- animal models all support the concept that CFEOM2 is a primary neurogenic abnormality with secondary myopathic changes...
  57. ncbi Magnetic resonance imaging evidence for widespread orbital dysinnervation in congenital fibrosis of extraocular muscles due to mutations in KIF21A
    Joseph L Demer
    Jules Stein Eye Institute, Department of Ophthalmology, University of California, Los Angeles, CA 90095 7002, USA
    Invest Ophthalmol Vis Sci 46:530-9. 2005
    ....
  58. ncbi Congential fibrosis of the extraocular muscles type I (CFEOM1) on the Arabian Peninsula
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, KSA
    Ophthalmic Genet 29:25-8. 2008
    ..To assess for KIF21A mutation in the first two reported Saudi Arabian families with the classic phenotype of congenital fibrosis of the extraocular muscles type I (CFEOM1)...
  59. pmc Congenital fibrosis of the extraocular muscles type 2, an inherited exotropic strabismus fixus, maps to distal 11q13
    S M Wang
    Division of Genetics, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Hum Genet 63:517-25. 1998
    ..We hypothesize that CFEOM2 results from an analogous developmental defect to CFEOM1, one that affects both the superior and inferior divisions of the oculomotor nerve and their corresponding alpha motoneurons and extraocular muscles...
  60. ncbi Blepharoptosis in Ibadan, Nigeria
    A M Baiyeroju
    Department of Ophthalmology, University College Hospital, Ibadan, Nigeria
    West Afr J Med 22:208-10. 2003
    To look into the cases of blepharoptosis in our environment as well as find out the causes and effects of the ptosis.
  61. ncbi KIF21A variant R954W in familial or sporadic cases of CFEOM1
    Guenther Rudolph
    Augenklinik der Ludwig Maximilians Universitat, München Germany
    Eur J Ophthalmol 19:667-74. 2009
    ..To demonstrate the clinical characteristics and determine mutations in the KIF21A gene, encoding a kinesin motor protein in patients with congenital fibrosis of the extraocular muscles (CFEOM) type 1...
  62. ncbi Ptosis: causes, presentation, and management
    Josef Finsterer
    Aesthetic Plast Surg 27:193-204. 2003
    ..Although improvement of the lid height is usually achieved, the eyelids may not appear perfectly symmetrical. In rare cases, full eyelid movement does not return. In some cases, more than one operation is required...
  63. ncbi EMG myokymia as a cause of ptosis in hypothyroidism
    Y L Lo
    Department of Neurology, Singapore General Hospital, Singapore
    Eur J Neurol 10:87-90. 2003
    ..In the absence of obvious aetiology, it is hypothesised that focal demyelination of terminal branches to the orbicularis oculi may play a role in the generation of the discharges...
  64. ncbi Long-term results of frontalis suspension using autogenous fascia lata for congenital ptosis in children under 3 years of age
    Igal Leibovitch
    Department of Ophthalmology, Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Am J Ophthalmol 136:866-71. 2003
    ..To evaluate the outcome of frontalis suspension surgery for congenital ptosis using autogenous fascia lata for children under 3 years of age...
  65. ncbi Genetic analysis of a five generation Indian family with BPES: a novel missense mutation (p.Y215C)
    Arun Kumar
    Department of Molecular Reproduction, Development, and Genetics, Indian Institute of Science, Bangalore, India
    Mol Vis 10:445-9. 2004
    ..The purpose of the present study was to carry out genetic analysis of BPES in a five-generation Indian family...
  66. ncbi Blepharoptosis correction with frontalis suspension using a supramid sling: duration of effect
    D Liu
    King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    Am J Ophthalmol 128:772-3. 1999
    ..To investigate the duration of effect after frontalis suspension with a Supramid (S. Jackson, Inc, Alexandria, Virginia) sling...
  67. ncbi Small incision transcutaneous levator aponeurotic repair for blepharoptosis
    Michael Baroody
    Division of Plastic Surgery, Pennsylvania State College of Medicine, Milton S Hershey Medical Center, Hershey, PA, USA
    Ann Plast Surg 52:558-61. 2004
    Patients presenting with blepharoptosis due to disinsertion or thinning of the levator aponeurosis require surgical repair...
  68. ncbi Intraoperative quantification using finger force for involutional blepharoptosis without postoperative lagophthalmos
    Hirohiko Kakizaki
    Department of Ophthalmology, Aichi Medical University, Aichi, Japan
    Jpn J Ophthalmol 50:135-40. 2006
    To report intraoperative quantification using finger force for involutional blepharoptosis, which helps in the prevention of postoperative lagophthalmos.
  69. ncbi A guide to making a natural eyelid margin curvature in blepharoptosis surgery
    Hirohiko Kakizaki
    Acta Ophthalmol Scand 82:240-1. 2004
  70. ncbi CFEOM3: a new extraocular congenital fibrosis syndrome that maps to 16q24.2-q24.3
    E J Doherty
    Department of Ophthalmology, Atlantic Health Sciences Corporation, Saint John, New Brunswick, Canada
    Invest Ophthalmol Vis Sci 40:1687-94. 1999
    ..To define the clinical characteristics and determine the gene localization for a previously undescribed form of congenital fibrosis of the extraocular muscles (CFEOM), referred to as CFEOM type 3 (CFEOM3)...
  71. ncbi Clinical phenotype and linkage analysis of the congenital fibrosis of the extraocular muscles in an Indian family
    C P Venkatesh
    Minto Eye Hospital, Bangalore, India
    Mol Vis 8:294-7. 2002
    ..To describe the clinical phenotype and linkage analysis of the congenital fibrosis of the extraocular muscles (CFEOM) in an Indian family...
  72. ncbi Histopathology of blepharoptosis induced by prolonged hard contact lens wear
    Akihide Watanabe
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Japan
    Am J Ophthalmol 141:1092-1096. 2006
    To clarify histopathologically the structural features of blepharoptosis in prolonged hard contact lens wearers.
  73. ncbi Long-term results of autogenous palmaris longus frontalis sling in children with congenital ptosis
    C Y Wong
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, People s Republic of China
    Eye (Lond) 19:546-8. 2005
    ..To investigate the long-term outcome of using autogenous palmaris longus tendon (PLT) sling for correcting congenital ptosis in children...
  74. ncbi Comparison of materials used in frontalis suspension
    B N Wasserman
    Princeton Eye Laser Center, NJ 08540, USA. hhtp://www.princetonlaser.com
    Arch Ophthalmol 119:687-91. 2001
    ..Other materials are useful for temporary eyelid elevation. All materials carry the risk of potential infection and/or granuloma formation...
  75. ncbi Outcomes of anterior levator resection in congenital blepharoptosis
    C A Cates
    Department of Ophthalmology, Salisbury District Hospital, Wiltshire, UK
    Eye 15:770-3. 2001
    PURPOSE: To identify any consistent factors which may predict over- or undercorrection of congenital blepharoptosis treated by anterior levator resection...
  76. ncbi Ruptured aneurysm of the sinus of Valsalva with Wildervanck syndrome (cervico-oculo-acoustic syndrome), blepharoptosis and short stature: case report
    Kotaro Oe
    Division of Internal Medicine, Houjukinen Hospital, Nomi, Japan
    Circ J 71:1485-7. 2007
    ..to these cardiovascular abnormalities, she had Wildervanck syndrome (Klippel-Feil syndrome, Duane syndrome and sensorineural hearing disturbance), blepharoptosis and short stature. This rare combination has not been reported previously.
  77. ncbi Restoration of involuntary tonic contraction of the levator muscle in patients with aponeurotic blepharoptosis or Horner syndrome by aponeurotic advancement using the orbital septum
    Kiyoshi Matsuo
    Department of Plastic and Reconstructive Surgery, Shinshu University School of Medicine, Matsumoto, Japan
    Scand J Plast Reconstr Surg Hand Surg 37:81-9. 2003
    ..from the tarsus by habitual rubbing, elongation of Müller's muscle secondary to thinning (aponeurotic blepharoptosis) or paralysis (Horner syndrome) desensitises the mechanoreceptor of Müller's muscle, resulting in ..
  78. ncbi Surgical correction of blepharoptosis using the levator aponeurosis-Müller's muscle complex readaptation technique: a 15-year experience
    Nicolo Scuderi
    Department of Plastic and Reconstructive Surgery, University of Rome La Sapienza, Italy
    Plast Reconstr Surg 121:71-8. 2008
    ..It may be caused by various abnormalities, both congenital and acquired. The aim of this article is to report the long-term follow-up of results obtained with the levator aponeurosis-Müller's muscle complex readaptation technique...
  79. ncbi Paradoxical use of frontalis muscle and the possible role of botulinum a toxin in permanent motor relearning
    Guy J Ben Simon
    Jules Stein Eye Institute and Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Ophthalmology 112:918-22. 2005
    ..Successful treatment with botulinum A toxin facilitated motor relearning and cessation of muscle contraction...
  80. ncbi Insertion of frontalis muscle relating to blepharoptosis repair
    Kun Hwang
    Department of Plastic Surgery, College of Medicine, Inha University, Incheon, Korea
    J Craniofac Surg 16:965-7. 2005
    ..aim of the study is to elucidate the precise anatomy and histologic structure of frontalis muscle relating to blepharoptosis repair. Five Korean adult cadavers were used...
  81. ncbi Isolated Muller's muscle resection for the correction of blepharoptosis
    R Khooshabeh
    Department of Opthalmology, Buckinghamshire Hospitals NHS Trust, Buckinghamshire, UK
    Eye (Lond) 22:267-72. 2008
    To assess the outcome of isolated Muller's muscle resection with preservation of conjunctiva in patients with blepharoptosis and good to moderate levator function.
  82. ncbi Two families with blepharophimosis/ptosis/epicanthus inversus syndrome have mutations in the putative forkhead transcription factor FOXL2
    R Bell
    The Medical Genetics Unit, St George s Hospital Medical School, Tooting, London SW17 ORE, UK
    Genet Test 5:335-8. 2001
    ....
  83. ncbi The molecular basis of the congenital fibrosis syndromes
    Elizabeth C Engle
    Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Strabismus 10:125-8. 2002
    ....
  84. ncbi Regional nerve block of the upper eyelid in oculoplastic surgery
    A R Ismail
    Portsmouth Eye Unit, Queen Alexandra Hospital, Cosham, Portsmouth, UK
    Eur J Ophthalmol 16:509-13. 2006
    ..To establish the efficacy of a regional nerve block of the upper eyelid and its effect on levator motor function...
  85. ncbi Revisiting upper eyelid anatomy: introduction of the septal extension
    Russell R Reid
    Division of Plastic Surgery, Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Plast Reconstr Surg 117:65-6; discussion 71-2. 2006
    ..In addition, this study may help to explain the increased rate of recurrence in ptosis repairs that incorporate plication techniques...
  86. ncbi Results of levator excision followed by fascia lata brow suspension in patients with congenital and jaw-winking ptosis
    Carolyn A Cates
    Department of Ophthalmology, West Suffolk Hospital, Bury St Edmunds, Suffolk, UK
    Orbit 27:83-9. 2008
    ..The purpose of the study was to examine the results of frontalis brow suspension after levator excision in patients with ptosis, and to determine whether satisfactory cosmetic results can be achieved with this procedure...
  87. ncbi Correcting aponeurotic ptosis
    David R Jordan
    Ophthalmology 113:163-4; author reply 164. 2006
  88. doi Re: "a randomized clinical trial of two methods of fascia lata suspension in congenital ptosis"
    Mohsen Bahmani Kashkouli
    Ophthal Plast Reconstr Surg 24:244; author reply 244-5. 2008
  89. ncbi [Analysis of treatment results 389 patients with congenital blepharoptosis]
    Kazimierz Kobus
    Kliniki Chirurgii Plastycznej Akademii Medycznej we Wrocławiu
    Klin Oczna 110:159-65. 2008
    Retrospective analysis of the results in the treatment of congenital blepharoptosis.
  90. ncbi Transient descent of the contralateral eyelid in unilateral ptosis surgery
    Edward J Wladis
    Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Ophthal Plast Reconstr Surg 24:348-51. 2008
    ..To report novel findings regarding contralateral eyelid height (i.e., intraoperative descent, followed by postoperative elevation) during unilateral ptosis surgery and to comment on their relevance in surgical planning...
  91. ncbi Safety and efficacy of silicone rod frontalis suspension surgery for childhood ptosis repair
    Carrie L Morris
    Duke University Eye Center, Durham, NC 27710, USA
    J Pediatr Ophthalmol Strabismus 45:280-8; quiz 289-90. 2008
    ..To evaluate the safety and efficacy of silicone rod frontalis suspension surgery for childhood ptosis...
  92. ncbi Re: "Horizontal eyelid movement on eyelid closure"
    Naser Owji
    Ophthal Plast Reconstr Surg 21:474; author reply 474-5. 2005
  93. ncbi Stability of silicone band frontalis suspension for the treatment of severe unilateral upper eyelid ptosis in infants
    P Fogagnolo
    G B Bietti Foundation IRCCS Istituto di Ricovero e Cura a Carattere Scientifico, Roma Italy
    Eur J Ophthalmol 18:723-7. 2008
    ..To address the efficacy, safety, and stability of frontalis suspension of the upper eyelid with a silicone band for the treatment of severe congenital ptosis in infants...
  94. ncbi Frontalis suspension for upper eyelid ptosis: evaluation of different surgical designs and suture material
    Guy J Ben Simon
    Division of Orbital and Ophthalmic Plastic Surgery, Jules Stein Eye Institute, CA 90095 7006, USA
    Am J Ophthalmol 140:877-85. 2005
    ..To compare two sling designs (single loop or double pentagon) and a variety of suture material that was used in frontalis suspension surgery for correction of upper eyelid ptosis...
  95. ncbi External levator advancement vs Müller's muscle-conjunctival resection for correction of upper eyelid involutional ptosis
    Guy J Ben Simon
    Jules Stein Eye Institute and Department of Ophthalmology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    Am J Ophthalmol 140:426-32. 2005
    ..To compare external levator advancement and Müller's muscle-conjunctival resection (conjunctivomullerectomy, or CJM) for correction of upper eyelid involutional ptosis...
  96. ncbi Re: "Effect of unilateral blepharoptosis on contralateral eyelid position"
    Allen M Putterman
    Ophthal Plast Reconstr Surg 21:323; author reply 324. 2005
  97. ncbi Modified tarsal resection operation for congenital ptosis with fair levator function
    Sarit M Patel
    Department of Ophthalmology, West Virginia University Eye Institute, West Virginia University, Morgantown, West Virginia, USA
    Ophthal Plast Reconstr Surg 24:1-6. 2008
    ..The authors review their 10-year experience with an en bloc resection of tarsus, Müller muscle, and conjunctiva in conjunction with graded levator aponeurosis advancement (a variation of the tarsectomy operation)...
  98. ncbi Predictability of conjunctival-Müellerectomy for blepharoptosis repair
    Eva Ayala
    Hospital San Juan de Dios, Santa Cruz, Tenerife, Spain
    Orbit 26:217-21. 2007
    To assess the predictability of the algorithm used to determine the amount of tissue resection for conjunctival-Müellerectomy during blepharoptosis repair.
  99. ncbi Approaches for correcting aponeurotic ptosis
    Kostas G Boboridis
    Ophthalmology 113:1889-90; author reply 1890-1. 2006
  100. ncbi The search for an ideal surgical procedure for pediatric congenital ptosis with poor to absent levator muscle function continues
    Rudolph S Wagner
    J Pediatr Ophthalmol Strabismus 43:206. 2006
  101. ncbi Tarsal switch levator resection for the treatment of blepharoptosis in patients with poor eye protective mechanisms
    Sheri L Demartelaere
    Texas Oculoplastic Consultants, Austin, Texas 78705, USA
    Ophthalmology 113:2357-63. 2006
    ..The authors report the use of a tarsal switch levator resection procedure that opens the palpebral fissure while reducing the risk of postoperative exposure in ptosis patients with poor eye protective mechanisms...

Research Grants6

  1. Pathogenesis of a Novel Limb-Girdle Muscular Dystrophy
    Michio Hirano; Fiscal Year: 2003
    ..For the patients, achieving the proposed goals will allow more accurate prenatal diagnosis, genetic counseling, and perhaps contribute to more rational therapies in the future. ..
  2. Prednisone Ocular Myasthenia Gravis Trial Planning Grant
    Mark Kupersmith; Fiscal Year: 2004
    ....
  3. GENETICS OF PARKINSON DISEASE IN THE AMISH
    Brad Racette; Fiscal Year: 2006
    ..abstract_text> ..
  4. Epidemilogy of Parkinsonism in Welders
    Brad A Racette; Fiscal Year: 2011
    ..The cohort assembled will provide unique opportunities for future research projects into gene-environment interactions and exposure related neuroimaging changes. ..