eye neoplasms

Summary

Summary: Tumors or cancer of the EYE.

Top Publications

  1. ncbi Ocular melanoma: a review and the relationship to cutaneous melanoma
    Eva A Hurst
    Division of Dermatology, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Dermatol 139:1067-73. 2003
  2. pmc Ocular surface squamous neoplasia in patients with HIV infection in sub-Saharan Africa
    Govardhanan Nagaiah
    Department of Medicine, Mary Babb Randolph Cancer Center, West Virginia University School of Medicine, 1 Medical Center Drive, Morgantown, WV 26506, USA
    Curr Opin Oncol 22:437-42. 2010
  3. ncbi Assessment of anterior segment tumors with ultrasound biomicroscopy versus anterior segment optical coherence tomography in 200 cases
    Carlos Bianciotto
    Wills Eye Institute, Thomas Jefferson University, Philadelphia, PA, USA
    Ophthalmology 118:1297-302. 2011
  4. pmc Association of human papilloma virus with pterygia and ocular-surface squamous neoplasia
    N Di Girolamo
    Inflammation and Infection Research Centre, School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia
    Eye (Lond) 26:202-11. 2012
  5. ncbi Rapidly increasing incidence of ocular non-hodgkin lymphoma
    Roxana Moslehi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
    J Natl Cancer Inst 98:936-9. 2006
  6. ncbi T(14;18)(q32;q21) involving IGH and MALT1 is a frequent chromosomal aberration in MALT lymphoma
    Berthold Streubel
    Department of Pathology, Division of Oncology, Vienna General Hospital, University of Vienna, Vienna, Austria
    Blood 101:2335-9. 2003
  7. pmc Extranodal marginal zone lymphoma of the ocular adnexa
    Alexandra Stefanovic
    Division of Hematology Oncology, Department of Medicine, Sylvester Comprehensive Cancer Center, University of Miami, 1475 NW 12th Ave, Miami, FL 33136, USA
    Blood 114:501-10. 2009
  8. ncbi Understanding intraocular lymphomas
    Sarah E Coupland
    Department of Cellular and Molecular Pathology, University of Liverpool, Liverpool, UK
    Clin Experiment Ophthalmol 36:564-78. 2008
  9. ncbi Tumors of the conjunctiva and cornea
    Carol L Shields
    Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Surv Ophthalmol 49:3-24. 2004
  10. pmc Ocular adnexal lymphoma: a clinicopathologic study of a large cohort of patients with no evidence for an association with Chlamydia psittaci
    Manuel F Rosado
    Sylvester Comprehensive Cancer Center, Division of Hematology Oncology, Department of Medicine, University of Miami, FL 33136, USA
    Blood 107:467-72. 2006

Research Grants

Detail Information

Publications245 found, 100 shown here

  1. ncbi Ocular melanoma: a review and the relationship to cutaneous melanoma
    Eva A Hurst
    Division of Dermatology, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Dermatol 139:1067-73. 2003
    ..We review the incidence and characteristics of OM, evaluate the existent data regarding its potential relationship to CM, and provide some guidance for the dermatologist regarding the evaluation and diagnosis of this ocular tumor...
  2. pmc Ocular surface squamous neoplasia in patients with HIV infection in sub-Saharan Africa
    Govardhanan Nagaiah
    Department of Medicine, Mary Babb Randolph Cancer Center, West Virginia University School of Medicine, 1 Medical Center Drive, Morgantown, WV 26506, USA
    Curr Opin Oncol 22:437-42. 2010
    ....
  3. ncbi Assessment of anterior segment tumors with ultrasound biomicroscopy versus anterior segment optical coherence tomography in 200 cases
    Carlos Bianciotto
    Wills Eye Institute, Thomas Jefferson University, Philadelphia, PA, USA
    Ophthalmology 118:1297-302. 2011
    ..To compare ultrasound biomicroscopy (UBM) versus anterior segment optical coherence tomography (AS-OCT) for imaging of tumors of the anterior segment of the eye...
  4. pmc Association of human papilloma virus with pterygia and ocular-surface squamous neoplasia
    N Di Girolamo
    Inflammation and Infection Research Centre, School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia
    Eye (Lond) 26:202-11. 2012
    ..Currently, over 60 million people worldwide have been immunized with HPV vaccines, but any effect on pterygium and OSSN development may not be known for some time as these lesions can evolve over decades or occur in older individuals...
  5. ncbi Rapidly increasing incidence of ocular non-hodgkin lymphoma
    Roxana Moslehi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
    J Natl Cancer Inst 98:936-9. 2006
    ..By contrast, other NHLs showed evidence of peaking in recent years. The distinctive patterns of ocular NHL call for further studies to identify risk factors and mechanisms, including the potential role of C. psittaci or other infections...
  6. ncbi T(14;18)(q32;q21) involving IGH and MALT1 is a frequent chromosomal aberration in MALT lymphoma
    Berthold Streubel
    Department of Pathology, Division of Oncology, Vienna General Hospital, University of Vienna, Vienna, Austria
    Blood 101:2335-9. 2003
    ..In contrast to t(11;18)(q21;q21)(+) MALT lymphomas, those with t(14;18)(q32;q21) may harbor additional genetic abnormalities...
  7. pmc Extranodal marginal zone lymphoma of the ocular adnexa
    Alexandra Stefanovic
    Division of Hematology Oncology, Department of Medicine, Sylvester Comprehensive Cancer Center, University of Miami, 1475 NW 12th Ave, Miami, FL 33136, USA
    Blood 114:501-10. 2009
    ..In this review, we present a state-of-the-art summary of ocular adnexal MALT lymphomas...
  8. ncbi Understanding intraocular lymphomas
    Sarah E Coupland
    Department of Cellular and Molecular Pathology, University of Liverpool, Liverpool, UK
    Clin Experiment Ophthalmol 36:564-78. 2008
    ..It would be preferable to refer to the various forms of intraocular lymphoma according to whether they are retinal, choroidal, ciliary or iridal and whether they are primary or secondary in these locations...
  9. ncbi Tumors of the conjunctiva and cornea
    Carol L Shields
    Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Surv Ophthalmol 49:3-24. 2004
    ..In this report, we provide clinical description and illustration of the many conjunctival and corneal tumors and we discuss tumor management...
  10. pmc Ocular adnexal lymphoma: a clinicopathologic study of a large cohort of patients with no evidence for an association with Chlamydia psittaci
    Manuel F Rosado
    Sylvester Comprehensive Cancer Center, Division of Hematology Oncology, Department of Medicine, University of Miami, FL 33136, USA
    Blood 107:467-72. 2006
    ..In South Florida, OALs are not associated with C psittaci infections...
  11. ncbi A novel approach for the adsorption of iodine-125 on silver wire as matrix for brachytherapy source for the treatment of eye and prostate cancer
    C Mathew
    Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India
    Appl Radiat Isot 57:359-67. 2002
    ..01%). 125I adsorbed on Pd coated silver wires could be used as a matrix for the preparation of interstitial sources in eye and prostate cancer therapy...
  12. ncbi Palladium-103 plaque radiotherapy for choroidal melanoma: an 11-year study
    Paul T Finger
    The New York Eye Cancer Center, St Vincent s Comprehensive Cancer Center, New York, NY 10021, USA
    Int J Radiat Oncol Biol Phys 54:1438-45. 2002
    ..To describe 11 years of experience with 103Pd ophthalmic plaque brachytherapy for intraocular melanoma...
  13. ncbi A pilot study of bevacizumab and interferon-α2b in ocular melanoma
    Kristan D Guenterberg
    Division of Surgical Oncology, The Ohio State University, Columbus, Ohio 43210, USA
    Am J Clin Oncol 34:87-91. 2011
    ....
  14. ncbi A case-control study of ocular surface squamous neoplasia (OSSN) in Uganda
    Keith Waddell
    Ruharo Eye Hospital, Uganda
    Int J Cancer 127:427-32. 2010
    ..We did not identify any additional factors that point to an underlying infectious cause, although this is an area of on-going research...
  15. ncbi Studies on the production and quality assurance of miniature (125)I radioactive sources suitable for treatment of ocular and prostate cancers
    S K Saxena
    Therapeutic and Reference Sources Section, Radiopharmaceuticals Division, RLG, BARC, Mumbai 400 085, India
    Appl Radiat Isot 64:441-7. 2006
    ..The surface contamination on the sealed capsules was found to be<0.05 nCi or 1.85 Bq per source. The sources were used in the treatment of a child having retinoblastoma...
  16. ncbi Squamous carcinoma and dysplasia of the conjunctiva and cornea: an analysis of 101 cases
    Yacoub A Yousef
    The New York Eye Cancer Center, The New York Eye and Ear Infirmary and the New York University School of Medicine, New York, New York, USA
    Ophthalmology 119:233-40. 2012
    ..To evaluate clinical and histopathologic factors of squamous conjunctival neoplasia associated with recurrence...
  17. ncbi A TNM-based clinical staging system of ocular adnexal lymphomas
    Sarah E Coupland
    Department of Pathology, School of Cancer Studies, University of Liverpool, Duncan Bldg, Daulby St, Liverpool L69 3GA, England
    Arch Pathol Lab Med 133:1262-7. 2009
    ..The Ann Arbor system has several shortcomings, particularly when staging extranodal non- Hodgkin lymphomas, such as OAL, which show different dissemination patterns from nodal lymphomas...
  18. ncbi Ultra-high resolution optical coherence tomography for differentiation of ocular surface squamous neoplasia and pterygia
    Jeremy Z Kieval
    Bascom Palmer Eye Institute, University of Miami, Miami, FL 33136, USA
    Ophthalmology 119:481-6. 2012
    ..To assess the use of an ultra-high-resolution (UHR) optical coherence tomography (OCT) as an adjuvant diagnostic tool in distinguishing ocular surface squamous neoplasia (OSSN) and pterygia...
  19. ncbi Vitreous cytokine levels
    Lesley A Wolf
    Ophthalmology 110:1671-2. 2003
  20. ncbi Clinical, histopathological, and immunogenetic analysis of ocular adnexal lymphoproliferative disorders: characterization of malt lymphoma and reactive lymphoid hyperplasia
    T Mannami
    Second Department of Internal Medicine, Okayama University Medical School, Okayama, Japan
    Mod Pathol 14:641-9. 2001
    ..PCR analysis was useful for differentiation between MALT lymphoma and RLH. Sequence analysis of VH genes showed that an autoimmune mechanism may be involved in the lymphomagenesis of ocular adnexal MALT lymphoma...
  21. ncbi Ocular and central nervous system lymphoma: clinical features and diagnosis
    N Cassoux
    Department of Ophthalmology, Pitie Salpetriere Hospital, Paris, France
    Ocul Immunol Inflamm 8:243-50. 2000
    ..To evaluate the clinical, angiographic, and cytopathologic features of ocular and central nervous system (CNS) lymphoma...
  22. pmc IL-10 measurement in aqueous humor for screening patients with suspicion of primary intraocular lymphoma
    Nathalie Cassoux
    Department of Ophthalmology, Hopital Pitie Salpetriere, Paris, France
    Invest Ophthalmol Vis Sci 48:3253-9. 2007
    ..To determine the value of IL-10 measurement in aqueous humor (AH) for screening in primary intraocular lymphoma (PIOL)...
  23. ncbi Ocular Adnexal Lymphoma: no evidence for bacterial DNA associated with lymphoma pathogenesis
    Julie M Matthews
    Sylvester Comprehensive Cancer Center, Division of Hematology Oncology, Department of Medicine, University of Miami, Miami, FL 33136, USA
    Br J Haematol 142:246-9. 2008
    ..No bacterial DNA that could be implicated in OAL pathogenesis was detected, suggesting that bacterial infection is not associated with OAL in South Florida...
  24. ncbi Macrophages are vital in spontaneous intraocular tumor eradication
    Zita F H M Boonman
    Department of Ophthalmology, Leiden University Medical Center, The Netherlands
    Invest Ophthalmol Vis Sci 47:2959-65. 2006
    ..This study was conducted to determine whether macrophages are involved in the natural elimination of this intraocular tumor...
  25. ncbi Primary intraocular lymphoma: clinical, cytologic, and flow cytometric analysis
    Renzo A Zaldivar
    Department of Ophthalmology, Emory University, Atlanta, Georgia, USA
    Ophthalmology 111:1762-7. 2004
    ..To compare cytologic with flow cytometric results of vitreous biopsy specimens obtained to rule out primary intraocular lymphoma (PIOL)...
  26. ncbi Analysis of clonal immunoglobulin heavy chain rearrangements in ocular lymphoma
    Joachim M Baehring
    Brain Tumor Center, Department of Neurology, Massachusetts General Hospital, 100 Blossom Street, Boston, MA 02114, USA
    Cancer 104:591-7. 2005
    ..The analysis of immunoglobulin heavy chain (IgH) gene rearrangements (AIGHR) was used as an adjunct to cytopathology and flow cytometry in systemic lymphoma. In IOL, the sensitivity and specificity of AIGHR are unknown...
  27. ncbi The Collaborative Ocular Melanoma Study: an overview
    Curtis E Margo
    Department of Opthalmology, Watson Clinic, LLP, Lakeland, FL 33805, USA
    Cancer Control 11:304-9. 2004
    ..The third arm is an observational study of small choroidal melanomas. Patient accrual ran from 1987 to 1998...
  28. ncbi Human papillomavirus: a predictor of better survival in ocular surface squamous neoplasia patients
    Sheetal Chauhan
    Department of Ocular Pathology, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India
    Br J Ophthalmol 96:1517-21. 2012
    ..In this study the presence and significance of HPV in OSSN and its correlation with p16(INK4a) immunoexpression was determined...
  29. ncbi Epicorneal polypoidal lipodermoid: lack of association of central corneal lesions with goldenhar syndrome verified with a review of the literature
    Frederick A Jakobiec
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA
    Surv Ophthalmol 55:78-84. 2010
    ..Other epibulbar choristomas that can be confused with lipodermoids are described...
  30. ncbi Fine-needle aspiration biopsy and other biopsies in suspected intraocular malignant disease: a review
    Nils Eide
    Vitreoretinal and Ocular Oncology Service, Department of Ophthalmology, Ulleval University Hospital, Oslo, Norway
    Acta Ophthalmol 87:588-601. 2009
    ..Our view is controversial and contrary to opinion that supports current standards of care for this group of patients...
  31. ncbi The past decade of experience with isolated hepatic perfusion
    Amelia Grover
    Surgical Metabolism Section, National Cancer Institute NIH, 10 Center Drive, Building 10, Room 2B07, Bethesda, Maryland 20892 1502, USA
    Oncologist 9:653-64. 2004
    ..Patient selection is important to ensure good results with minimal morbidity and mortality. Work to define the appropriate clinical groups is ongoing at many clinical centers...
  32. ncbi Treatment of mucosa-associated lymphoid tissue-type ocular adnexal lymphoma
    Didier Decaudin
    Department of aClinical Hematology, Translational Research Department, Institut Curie, France
    Anticancer Drugs 19:673-80. 2008
    ..The aims of this review are therefore to present the various treatment modalities and to discuss the place of each modality in the management of ophthalmologic lymphomas...
  33. ncbi Feasibility of the TNM-based staging system of ocular adnexal extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)
    Sung Eun Lee
    Department of Hematology, Catholic University Lymphoma Group, The Catholic University of Korea, College of Medicine, Seoul, Korea
    Am J Hematol 86:262-6. 2011
    ..Thus, further studies to develop treatment strategies for reducing relapse after treatment for OAML should use the TNM staging system...
  34. ncbi Vision-threatening complications of nasal T/NK lymphoma
    Charmaine Hon
    Department of Ophthalmology, Queen Mary Hospital, Hong Kong, China
    Am J Ophthalmol 134:406-10. 2002
    ..CONCLUSION: Both oncologists and ophthalmologists should be aware of ocular complications when dealing with known or suspected cases of T/NK lymphoma at diagnosis and relapse. Regular ophthalmic assessment of these patients is warranted...
  35. ncbi Primary intraocular lymphoma: a review
    Gregory S Vosganian
    Division of Hematology Oncology, Scripps Clinic, 10666 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Neurooncol 105:127-34. 2011
    ..She enjoyed a 16-month remission but ultimately recurred in the brain. We reviewed the literature and present a discussion of the diagnostic criteria for PIOL and current strategies for treating PIOL in immunocompetent patients...
  36. ncbi Ocular surface squamous neoplasia (OSSN) and human immunodeficiency virus at Sekuru Kaguvi Eye Unit in Zimbabwe: the role of operational research studies in a resource poor environment?
    T S Chinogurei
    Department of Surgery, University of Zimbabwe, College of Health Sciences, Avondale
    Cent Afr J Med 52:56-8. 2006
    ..To determine the extent of association and relative risk of developing ocular surface squamous neoplasia (OSSN) among HIV positive patients seen in July 2004 at Sekuru Kaguvi Eye Unit, in Harare, Zimbabwe...
  37. ncbi Lacrimal gland extranodal marginal zone B-cell lymphoma of MALT-type
    Shu Ching Kao
    Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    Am J Ophthalmol 143:311-316. 2007
    ..To evaluate the clinical features and outcome of extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type (MALT lymphoma) in the lacrimal gland...
  38. ncbi Diagnosis and management of conjunctival and corneal intraepithelial neoplasia using ultra high-resolution optical coherence tomography
    Mohamed Abou Shousha
    Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, Florida, USA
    Ophthalmology 118:1531-7. 2011
    ..To report a novel diagnostic technique and a case series of conjunctival and corneal intraepithelial neoplasia (CCIN) diagnosed and followed up using prototype ultra high-resolution (UHR) optical coherence tomography (OCT)...
  39. ncbi The National Cancer Data Base report on cutaneous and noncutaneous melanoma: a summary of 84,836 cases from the past decade. The American College of Surgeons Commission on Cancer and the American Cancer Society
    A E Chang
    Division of Surgical Oncology, University of Michigan Medical Center, Ann Arbor, USA
    Cancer 83:1664-78. 1998
    ..This study reviews the case-mix characteristics, management, and outcomes of melanoma cases occuring in the U.S. within the last decade...
  40. ncbi Radiotherapy and cataract formation
    Zandra K Ferrufino-Ponce
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Comprehensive Ophthalmology Service, Boston, MA 02114, USA
    Semin Ophthalmol 21:171-80. 2006
    ..Recently, additional studies have given insight into this important relationship and the efficacy of treatment options...
  41. pmc Diagnosis of ocular surface lesions using ultra-high-resolution optical coherence tomography
    Mohamed Abou Shousha
    Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, Miami, Florida 33136, USA
    Ophthalmology 120:883-91. 2013
    ..To assess the use of ultra-high-resolution (UHR) optical coherence tomography (OCT) in the diagnosis of ocular surface lesions...
  42. pmc Molecular pathology of primary intraocular lymphoma
    Chi Chao Chan
    National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA
    Trans Am Ophthalmol Soc 101:275-92. 2003
    ..To evaluate immunoglobulin heavy chain (IgH) gene rearrangements, cytokines and chemokines, and infectious agents in primary intraocular B-cell lymphoma (PIOL) cells, in order to better diagnose and understand PIOL...
  43. ncbi Vitreous and retinal metastasis from gastric cancer
    Chang Yeom Kim
    Department of Ophthalmology, Cheju Halla General Hospital, Jeju Korea
    Eur J Ophthalmol 20:615-7. 2010
    ..Intraocular metastasis from gastric cancer is not common and metastatic carcinoma to the vitreous or retina is exceedingly rare. We describe a case of gastric cancer metastatic to the vitreous and retina...
  44. ncbi Orbital rhabdomyosarcoma
    Zeynel A Karcioglu
    Department of Ophthalmology and Cancer Center, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Cancer Control 11:328-33. 2004
    ..Although rhabdomyosarcoma (RMS) is a rare tumor among the entire group of mesenchymal malignancies, it is a relatively common lesion and significant challenge for the ocular oncologist in terms of its diagnosis and management...
  45. pmc Detection of the bcl-2 t(14;18) translocation and proto-oncogene expression in primary intraocular lymphoma
    Dana J Wallace
    Laboratory of Immunology, Division of Epidemiology and Clinical Research, National Eye Institute, National Institutes of Health, Bethesda, MD 20895 1857, USA, and Department of Ophthalmology, Tokyo Medical and Dental University, Japan
    Invest Ophthalmol Vis Sci 47:2750-6. 2006
    ..This study examined the expression of the bcl-2 t(14;18) translocation, the bcl-10 gene, and high expression of bcl-6 mRNA in PIOL cells...
  46. ncbi Cutaneous malignant melanoma metastatic to the eye, lids, and orbit
    Caroline Rosenberg
    The New York Eye Cancer Center, New York, NY 10065, USA
    Surv Ophthalmol 53:187-202. 2008
    ..Therefore, patients with ocular metastasis should be managed to prevent loss of vision or loss of the eye, and to maximize their quality of life...
  47. ncbi Disseminated metastasis following periampullary cancer resection masquerading as uveitis
    Sushmita Kaushik
    Department of Ophthalmology, Postgraduate Institute of Medical Education and Research, Chandigarh 160 012, India
    Indian J Ophthalmol 53:57-9. 2005
    ..The Masquerade Syndrome was detected by cytological examination of the vitreous...
  48. pmc 25-Gauge transconjunctival sutureless vitrectomy for the diagnosis of intraocular lymphoma
    Steven Yeh
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Building 10, 10N 112, 10 Center Drive, Bethesda, MD 20892, USA
    Br J Ophthalmol 94:633-8. 2010
    ..The availability of expert ophthalmic pathological consultation, flow cytometry, cytokine evaluation and gene rearrangement studies were essential to the diagnosis...
  49. ncbi Ocular neoplastic disease
    Amit Mahajan
    Department of Diagnostic Radiology, Yale New Haven Hospital, New Haven, CT, USA
    Semin Ultrasound CT MR 32:28-37. 2011
    ....
  50. ncbi [A case of intraocular malignant lymphoma diagnosed by immunoglobulin gene rearrangement and translocation, and IL-10/IL-6 ratio in the vitreous fluid]
    Mako Yokota
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 0034, Japan
    Nihon Ganka Gakkai Zasshi 107:287-91. 2003
    ..We report here a case where we used the new diagnostic tests and the results aided us to make a diagnosis of intraocular lymphoma...
  51. pmc Anterior chamber paracentesis cytology (cytospin technique) for the diagnosis of intraocular lymphoma
    P T Finger
    The New York Eye Cancer Center, 115 E 61st Street, New York City, NY 10021, USA
    Br J Ophthalmol 90:690-2. 2006
    ..To report on the diagnosis of intraocular lymphoma by aqueous cytology...
  52. ncbi Sun exposure predicts risk of ocular melanoma in Australia
    Claire M Vajdic
    Cancer Research and Registers Division, New South Wales Cancer Council, Sydney, Australia
    Int J Cancer 101:175-82. 2002
    ..There was inconclusive evidence for an association between sun exposure and iris (n = 25) or conjunctival (n = 19) melanomas. Sun exposure is an independent risk factor for choroidal and ciliary body melanoma in Australia...
  53. ncbi Incidence of noncutaneous melanomas in the U.S
    Colleen C McLaughlin
    New York State Cancer Registry, New York State Department of Health, Albany, New York 12237, USA
    Cancer 103:1000-7. 2005
    ..The current report was the largest in-depth descriptive analysis of incidence of noncutaneous melanoma in the United States, using data from the North American Association of Central Cancer Registries...
  54. ncbi SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene
    J A DeCaprio
    Division of Neoplastic Disease Mechanisms, Dana Farber Cancer Institute, Boston, Massachusetts
    Cell 54:275-83. 1988
    ..These results are consistent with a model for transformation by SV40 which, at least in part, involves T/p110-114 complex formation and the perturbation of Rb protein and/or T function...
  55. doi Rare occurrence of IgVH gene translocations and restricted IgVH gene repertoire in ocular MALT-type lymphoma
    Patrick Adam
    Haematologica 93:319-20. 2008
    ..Three out of 8 cases analyzed used the highly mutated VH3-23 gene and showed ongoing somatic hypermutations...
  56. ncbi Temporally distinct patterns of p53-dependent and p53-independent apoptosis during mouse lens development
    H Pan
    Department of Anatomy, University of Wisconsin Medical School, Madison 53706, USA
    Genes Dev 9:2157-69. 1995
    ....
  57. ncbi Chlamydia infection and lymphomas: association beyond ocular adnexal lymphomas highlighted by multiple detection methods
    Maurilio Ponzoni
    Pathology Unit, San Raffaele Scientific Institute, Milano, Italy
    Clin Cancer Res 14:5794-800. 2008
    ..Herein, we used multiple Chlamydia detection tools to identify Cp elementary bodies-containing cell and to assess Cp prevalence in both nodal and extranodal lymphomas...
  58. ncbi Evidence for an association between Chlamydia psittaci and ocular adnexal lymphomas
    Andres J M Ferreri
    Department of Radiochemotherapy, San Raffaele H Scientific Institute, Milan, Italy
    J Natl Cancer Inst 96:586-94. 2004
    ..Hence, we assessed whether Chlamydiae infection is associated with the development of ocular adnexal lymphomas...
  59. ncbi Expression of vascular endothelial growth factor (VEGF) and its receptors is regulated in eyes with intra-ocular tumours
    A W Stitt
    Department of Ophthalmology, Queen s University of Belfast, Northern Ireland, U K
    J Pathol 186:306-12. 1998
    ..Retinal vascular endothelia may respond to high intra-ocular levels of VEGF by increasing expression of their VEGF receptors, a phenomenon which could have relevance to neoplasm-related ocular neovascularization...
  60. ncbi Trends in the incidence of ocular melanoma in the United States, 1974-1998
    Peter D Inskip
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 7238, USA
    Cancer Causes Control 14:251-7. 2003
    ..A recent report noted a fourfold risk of ocular melanoma associated with employment in occupations involving use of cellular telephones...
  61. ncbi Absence of Chlamydia psittaci in ocular adnexal lymphoma from Japanese patients
    Masanori Daibata
    Br J Haematol 132:651-2. 2006
  62. ncbi Radiotherapy for orbital lymphoma : outcome and late effects
    Marc Bischof
    Department of Radiooncology, University of Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany
    Strahlenther Onkol 183:17-22. 2007
    ..To analyze the effectiveness of radiotherapy in the management of orbital non-Hodgkin's lymphoma (NHL)...
  63. ncbi Chlamydia psittaci infection and clinicopathologic analysis of ocular adnexal lymphomas in Korea
    Changhoon Yoo
    Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    Am J Hematol 82:821-3. 2007
    ..Our study demonstrates an association between OAL and Cp infection in Korea, suggesting that Cp plays a role as a causative antigen in Korean OAL patients...
  64. ncbi Diagnostic testing of vitrectomy specimens
    Janet L Davis
    Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Am J Ophthalmol 140:822-829. 2005
    ..To assess the usefulness of diagnostic tests that are performed on vitrectomy specimens from patients with suspected lymphoma or infection...
  65. ncbi A mass of the right lacrimal sac in a 53-year-old man
    Changlee Seo Pang
    Department of Pathology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614 0568, USA
    Arch Pathol Lab Med 129:1493-4. 2005
  66. ncbi Bilateral metastases to extraocular muscles from lobular breast carcinoma
    John R Kouvaris
    Department of Radiation Oncology, Aretaieion Hospital, Athens, Greece
    Onkologie 31:387-9. 2008
    ..Metastastic carcinoma to extraocular muscles is extremely rare, but even more so is the case of a bilateral one...
  67. ncbi Epigenetic silencing of the CIITA gene and posttranscriptional regulation of class II MHC genes in ocular melanoma cells
    Michael Radosevich
    Department of Immunology, University College London, University of London, Moorfields Eye Hospital, London, United Kingdom
    Invest Ophthalmol Vis Sci 45:3185-95. 2004
    ..However, the mechanism(s) of this suppression is unknown. In this study, we have probed the molecular basis of this phenotype and report two distinct mechanisms underlying this phenotype...
  68. ncbi Sebaceous carcinoma of the ocular region: a review
    Jerry A Shields
    Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Surv Ophthalmol 50:103-22. 2005
    ....
  69. ncbi Lack of an association between Chlamydia psittaci and ocular adnexal lymphoma
    Grace S Zhang
    Department of Ophthalmology, Northwestern University Chicago, IL 60611, USA
    Leuk Lymphoma 48:577-83. 2007
    ..psittaci infection in various geographic regions or technical differences in the application of the assays may underlie the variability in the association between C. psittaci and ocular adnexal lymphoma...
  70. ncbi Clinical features associated with survival of patients with lymphoma of the ocular adnexa
    C Jenkins
    Orbital Clinic Moorfields Eye Hospital City Road, London, UK
    Eye (Lond) 17:809-20. 2003
    ..The outcome of malignant ocular adnexal lymphoma was, therefore, related to presenting clinical symptoms and signs...
  71. ncbi Neoplastic masquerade syndromes
    Russell W Read
    Doheny Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Surv Ophthalmol 47:81-124. 2002
    ....
  72. ncbi Chlamydia psittaci is variably associated with ocular adnexal MALT lymphoma in different geographical regions
    E Chanudet
    Department of Pathology, University of Cambridge, UK, and Nanfang Hospital, Southern Medical University, Guangzhou, China
    J Pathol 209:344-51. 2006
    ..In conclusion, our results show that C. psittaci, but not C. pneumoniae, C. trachomatis, HSV1, HSV2, ADV8 or ADV19, is associated with ocular adnexal MALT lymphoma and that this association is variable in different geographical areas...
  73. ncbi Variable association between Chlamydophila psittaci infection and ocular adnexal lymphomas: methodological biases or true geographical variations?
    Didier Decaudin
    Department of Clinical Hematology, Institut Curie, Paris, France
    Anticancer Drugs 19:761-5. 2008
    ..psittaci antibodies. This paper also provides some methodological suggestions for future studies in the field of chlamydia-lymphoma associations...
  74. ncbi Impaired th1/tc1 cytokine production of tumor-infiltrating lymphocytes in a model of primary intraocular B-cell lymphoma
    Valerie Touitou
    Immune Microenvironment and Tumors Group, INSERM UMRS872, Université Pierre et Marie Curie Paris, France
    Invest Ophthalmol Vis Sci 48:3223-9. 2007
    ..To study the immune microenvironment in intraocular lymphomas and to characterize the cytokine polarization of infiltrating T-lymphocytes, a new murine model of intraocular B-cell lymphoma was developed...
  75. ncbi Radiotherapy for extranodal, marginal zone, B-cell lymphoma of mucosa-associated lymphoid tissue originating in the ocular adnexa: a multiinstitutional, retrospective review of 50 patients
    Takashi Uno
    Department of Radiology, Chiba University Graduate School of Medicine, Chiba, Japan
    Cancer 98:865-71. 2003
    ....
  76. ncbi Hyperthermic isolated hepatic perfusion using melphalan for patients with ocular melanoma metastatic to liver
    H Richard Alexander
    Surgical Metabolism Section, Surgery Branch, Center for Cancer, National Cancer Institute, NIH, Bethesda, Maryland 20892 1502, USA
    Clin Cancer Res 9:6343-9. 2003
    ..Because median survival after diagnosis of liver metastases is short and no satisfactory treatment options exist, we have conducted clinical trials evaluating isolated hepatic perfusion (IHP) for patients afflicted with this condition...
  77. ncbi Lymphoma of the ocular adnexa: A study of 353 cases
    Judith A Ferry
    James Homer Wright Pathology Laboratories of the Massachusetts General Hospital, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Surg Pathol 31:170-84. 2007
    ..High-grade B-cell lymphomas only occasionally involve the ocular adnexa, and T-cell lymphoma, NK-cell lymphoma, and Hodgkin lymphoma are only rarely encountered in this site...
  78. ncbi Clinicopathologic analysis of ocular adnexal lymphomas: extranodal marginal zone b-cell lymphoma constitutes the vast majority of ocular lymphomas among Koreans and affects younger patients
    Eun Yoon Cho
    Department of Diagnostic Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    Am J Hematol 73:87-96. 2003
    ..Histologic subtype by WHO classification has a significant correlation with the final outcome, with the most favorable outcome associated with OALs of the MALT type...
  79. ncbi High-dose methotrexate for intraocular lymphoma
    Tracy T Batchelor
    Massachusetts General Hospital Brain Tumor Center and Neurology Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Clin Cancer Res 9:711-5. 2003
    ..We also sought to determine whether micromolar levels of MTX could be achieved in the aqueous and vitreous humor of the eye after i.v. administration of the drug...
  80. ncbi Intraocular lymphoma
    Chi Chao Chan
    Laboratory of Immunology National Eye Institute, National Institutes of Health, Building 10 Room 10N103, 10 Center Drive, Bethesda, MD 20892 1857, USA
    Curr Opin Ophthalmol 13:411-8. 2002
    ..Compared with PIOL, metastatic systemic lymphomas have a much lower prevalence, better prognosis, and are less likely to create a diagnostic dilemma...
  81. ncbi Management of lacrimal sac tumours
    D N Parmar
    Lacrimal Clinic, Moorfields Eye Hospital, London, UK
    Eye (Lond) 17:599-606. 2003
    ..To report a series of 15 primary lacrimal sac tumours and present an algorithm in managing this rare condition...
  82. pmc Complications of mitomycin C therapy in 100 eyes with ocular surface neoplasia
    J J Khong
    Department of Ophthalmology and Visual Science, Royal Adelaide Hospital, North Terrace, SA 5000, Australia
    Br J Ophthalmol 90:819-22. 2006
    ..To determine the complications associated with mitomycin C (MMC) in the treatment of ocular surface neoplasia...
  83. ncbi Role of topical chemotherapy for primary acquired melanosis and malignant melanoma of the conjunctiva and cornea: review of the evidence and recommendations for treatment
    Rajeev Chalasani
    Ocular Oncology Unit, Save Sight Institute, Sydney Eye Hospital, Sydney, New South Wales, Australia
    Clin Experiment Ophthalmol 34:708-14. 2006
    ..Topical MMC was well tolerated and shows considerable promise, particularly in the treatment of diffuse PAM with atypia. However, long-term data are lacking and further studies are required...
  84. pmc Long term outcome of ocular adnexal lymphoma subtyped according to the REAL classification. Revised European and American Lymphoma
    C Auw-Haedrich
    University Eye Hospital, Freiburg, Germany
    Br J Ophthalmol 85:63-9. 2001
    ..To classify ocular adnexal lymphomas according to the Revised European and American Lymphoma (REAL) classification and to determine any correlation between clinical features or histomorphological variables with the patients' outcome...
  85. ncbi Topical medical therapies for ocular surface tumors
    Antony M Poothullil
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Semin Ophthalmol 21:161-9. 2006
    ..Topical agents were used as both primary and adjuvant therapy. Rates of tumor regression for CIN and squamous cell carcinoma ranged from 80 to 96%, and 70% of pigmented tumors regressed after an average follow-up of 27 months...
  86. ncbi Positron emission tomography in the detection and staging of ocular adnexal lymphoproliferative disease
    Alejandra A Valenzuela
    Eyelid, Lacrimal and Orbital Clinic, Department of Ophthalmology, Division of Surgery, Royal Brisbane and Women s Hospital and the University of Queensland Medical School, Herston, Australia
    Ophthalmology 113:2331-7. 2006
    ..To evaluate the role of fluorine 18 deoxyglucose positron emission tomography (FDG PET) in the initial staging of ocular adnexal lymphoma (OAL)...
  87. pmc International Central Nervous System and Ocular Lymphoma Workshop: recommendations for the future
    Robert B Nussenblatt
    Laboratory of Immunology, National Eye Institute, NIH, 10 Center Drive, Building 10, Room 10S219, Bethesda, MD, 20892, USA
    Ocul Immunol Inflamm 14:139-44. 2006
    ..To bring together multidisciplinary experts to discuss primary central nervous system lymphoma (PCNSL) and primary intraocular lymphoma (PIOL)...
  88. ncbi Schneiderian papillomas and carcinomas: a review
    J G Batsakis
    Division of Pathology, University of Texas M. D. Anderson Cancer Center, Houston, USA
    Adv Anat Pathol 8:53-64. 2001
    ..Keratinization and hyperkeratosis in papillomas, however, are suggested to be sufficiently ominous as to warrant further study...
  89. ncbi Adenoid cystic carcinoma of the lacrimal gland with wide and severe myoepithelial differentiation
    Hiroyuki Mizokami
    Department of Otolaryngology Head and Neck Surgery, Saga Medical School, Saga 849 8501, Japan
    Auris Nasus Larynx 29:77-82. 2002
    ..Accurate diagnosis is important because tumor histopathology is generally believed to be the most significant factor in patient survival...
  90. ncbi A gene transfer comparative study of HSA-conjugated antiangiogenic factors in a transgenic mouse model of metastatic ocular cancer
    E Frau
    CNRS UMR 8121 Univ Paris Sud, Vectorologie et Transfert de Gènes, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif, France
    Cancer Gene Ther 14:251-61. 2007
    ..Our study indicates that systemic antiangiogenic factors production by recombinant adenoviruses, particularly Can, might represent an effective way of delaying metastatic growth via inhibition of angiogenesis...
  91. ncbi Treatment outcomes for primary intraocular lymphoma: implications for external beam radiotherapy
    A Berenbom
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO, USA
    Eye (Lond) 21:1198-201. 2007
    ..Our aim was to confirm whether these concerns about radiotherapy were borne out in patients treated at our institution over the last decade...
  92. ncbi An Asian patient with intraocular lymphoma treated by intravitreal methotrexate
    Jia kang Wang
    Department of Ophthalmology, Far Eastern Memorial Hospital, Taipei, Taiwan
    Jpn J Ophthalmol 50:474-8. 2006
    ..To demonstrate the efficacy of intravitreal methotrexate for treating intraocular lymphoma...
  93. ncbi Efficacy of chemotherapy as a first-line treatment in ocular adnexal extranodal marginal zone B-cell lymphoma
    E K Song
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Ann Oncol 19:242-6. 2008
    ..This study was undertaken to analyze the efficacy of first-line chemotherapy in treating EMZBL. Chemotherapy was followed by radiotherapy only in recurrent cases...
  94. ncbi Regression of ocular adnexal lymphoma after Chlamydia psittaci-eradicating antibiotic therapy
    Andres J M Ferreri
    Department of Radiochemotherapy, San Raffaele H Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
    J Clin Oncol 23:5067-73. 2005
    ..The present pilot study was carried out to assess whether C psittaci-eradicating antibiotic therapy is associated with tumor regression in ocular adnexal lymphomas...
  95. ncbi Ocular melanoma in a Long Evans rat
    Walter S Manning
    Veterinary Consultant, 2055 Mary Ann Lane, Burleson, Texas 76028 2229, USA
    Contemp Top Lab Anim Sci 43:44-6. 2004
    ..By visual examination, a presumptive diagnosis of ocular melanoma was made. Subsequent surgical removal of the eye, followed by histopathology, confirmed the lesion as a highly pigmented epitheliod melanoma...
  96. ncbi Intravitreal methotrexate for treating vitreoretinal lymphoma: 10 years of experience
    S Frenkel
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Br J Ophthalmol 92:383-8. 2008
    ..To describe our experience in treating vitreoretinal involvement of primary central nervous system lymphoma, by intravitreal injections of methotrexate (MTX)...
  97. pmc Non-cell-autonomous induction of tissue overgrowth by JNK/Ras cooperation in a Drosophila tumor model
    Mirka Uhlirova
    Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 102:13123-8. 2005
    ..Thus, depending on the genetic context, JNK signaling can eradicate tumors by removing premalignant cells, or promote aberrant overgrowth in tissues surrounding primary lesions...
  98. ncbi Diagnosis of intraocular lymphoma
    Janet L Davis
    University of Miami School of Medicine, Bascom Palmer Eye Institute, Miami, FL 33136, USA
    Ocul Immunol Inflamm 12:7-16. 2004
    ..To review current techniques for the diagnosis of intraocular lymphoma...
  99. ncbi Extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue-type of the orbit and ocular adnexa
    Jae Lyun Lee
    Department of Medicine, Yeungnam University College of Medicine, Nam Gu, 705 717 Daegu, South Korea
    Ann Hematol 84:13-8. 2005
    ..Radiotherapy alone can produce excellent local control and survival in patients with localized MALT lymphoma of OOA. Systemic chemotherapy should be considered in patients with advanced stages or systemic manifestation...
  100. ncbi Ocular adnexal lymphoma: clinical behavior of distinct World Health Organization classification subtypes
    Claire Y Fung
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Int J Radiat Oncol Biol Phys 57:1382-91. 2003
    ..To evaluate the clinical behavior and treatment outcome of ocular adnexal lymphomas classified by the World Health Organization system, with emphasis on marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT)...
  101. ncbi Regional treatment options for patients with ocular melanoma metastatic to the liver
    Elizabeth D Feldman
    Surgical Metabolism Section, Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 1502, USA
    Ann Surg Oncol 11:290-7. 2004
    ..This article reviews the efficacy, outcomes, and morbidities of the multiple locoregional therapies available today...

Research Grants12

  1. OCULAR MELANOMA
    Paul Finger; Fiscal Year: 2003
    ..Standardized clinical and data collection procedures will be employed, and standardized forms will be used in all centers. Central training and certification of all study staff will be required. ..
  2. Prediction of Second Cancer Risks for Children Treated with Proton - vs. - Photon
    Wayne D Newhauser; Fiscal Year: 2010
    ..In the future, we expect that the lower-risk treatments will result in fewer second cancers and this will translate into longer, higher-quality lives for survivors of childhood cancer (presently 270,000 persons in the United States). ..
  3. Molecular Classification and Therapy of CNS Lymphomas
    James Rubenstein; Fiscal Year: 2008
    ..We will perform gene expression profile analysis of these tumors from diagnostic specimens obtained from a frozen tumor bank to identify a set of genes, which can be used to predict outcome. ..
  4. Requirements for Normal Rb Function In Vivo
    David W Goodrich; Fiscal Year: 2010
    ..Successful completion of these specific aims will identify a new mechanism contributing to Rb1 tumor suppression and suggest new therapeutic strategies to treat prostate cancer. ..
  5. The Role of Thoc1 in Normal Development and Cancer
    David W Goodrich; Fiscal Year: 2011
    ..The experiments proposed will determine whether pThod is a promising target for the development of new therapies and prognostic tests. ..
  6. MICROARRAY ANALYSIS OF RETINAL DEGENERATION IN MICE
    Caroline Zeiss; Fiscal Year: 2007
    ..Colin Barnstable, Professor of Neurobiology and Ophthalmology, who is an internationally recognized molecular biologist using mouse models of retinal development and degeneration. ..
  7. Modulation of Aflatoxin B1-induced hepatocarcinogenesis by RB loss
    Erik Knudsen; Fiscal Year: 2007
    ..These studies will identify critical facets of RB function in vivo and delineate specific consequences of RB loss that are germane to tumor formation following genotoxic insult. [unreadable] [unreadable] [unreadable]..
  8. Experimental Uveal Melanoma and Ocular Immune Privilege
    KYLE MCKENNA; Fiscal Year: 2007
    ..abstract_text> ..
  9. Ultrasound-Enhanced Delivery of Medications to the Eye
    Ronald Silverman; Fiscal Year: 2008
    ..We will visualize the distribution of the molecules within the sclera, choroid and retina to evaluate transport and characterize any tissue damage that might have occurred microscopically and by apoptosis assays. ..
  10. Mechanism of mutant TIMP-3 induced neovascularization
    Michael Tolentino; Fiscal Year: 2004
    ..Specific aim 3: To develop and test gene vectors expressing inhibitors of angiogenesis (angiostatin, endostatin, PEDF) and test their ability to inhibit subretinal neovascularization in the mutant transgenic mouse. ..
  11. Molecular Targets for Drug and Radiation Sensitivity
    Stephen Hahn; Fiscal Year: 2007
    ..abstract_text> ..
  12. Clinical Trials of FTI Radiosensitization
    Stephen Hahn; Fiscal Year: 2005
    ..Specific molecular markers that are associated with activation of the Ras signaling pathway will be measured in NSCLC tumor biopsy specimens and will be related to the clinical efficacy of R115777 and radiotherapy. ..