corneal neovascularization

Summary

Summary: New blood vessels originating from the corneal veins and extending from the limbus into the adjacent CORNEAL STROMA. Neovascularization in the superficial and/or deep corneal stroma is a sequel to numerous inflammatory diseases of the ocular anterior segment, such as TRACHOMA, viral interstitial KERATITIS, microbial KERATOCONJUNCTIVITIS, and the immune response elicited by CORNEAL TRANSPLANTATION.

Top Publications

  1. pmc Corneal angiogenic privilege: angiogenic and antiangiogenic factors in corneal avascularity, vasculogenesis, and wound healing (an American Ophthalmological Society thesis)
    Dimitri T Azar
    Massachusetts Eye and Ear Infirmary and Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts, USA
    Trans Am Ophthalmol Soc 104:264-302. 2006
  2. ncbi Bevacizumab as a potent inhibitor of inflammatory corneal angiogenesis and lymphangiogenesis
    Felix Bock
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 48:2545-52. 2007
  3. ncbi The mouse cornea micropocket angiogenesis assay
    Michael S Rogers
    The Vascular Biology Program, Children s Hospital Boston, and Department of Ophthalmology, Harvard Medical School, 300 Longwood Ave, Boston, Massachusetts 02115, USA
    Nat Protoc 2:2545-50. 2007
  4. ncbi Subconjunctival injection of recombinant AAV-angiostatin ameliorates alkali burn induced corneal angiogenesis
    Huey Chuan Cheng
    Department of Ophthalmology, Mackay Memorial Hospital, Taipei, Taiwan
    Mol Vis 13:2344-52. 2007
  5. ncbi Inhibition of hemangiogenesis and lymphangiogenesis after normal-risk corneal transplantation by neutralizing VEGF promotes graft survival
    Claus Cursiefen
    Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 45:2666-73. 2004
  6. ncbi Comparative evaluation of FGF-2-, VEGF-A-, and VEGF-C-induced angiogenesis, lymphangiogenesis, vascular fenestrations, and permeability
    Renhai Cao
    Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
    Circ Res 94:664-70. 2004
  7. pmc Localization of angiotensin converting enzyme in rabbit cornea and its role in controlling corneal angiogenesis in vivo
    Ajay Sharma
    Harry S Truman Memorial Veterans Hospital, Columbia, MO 65212, USA
    Mol Vis 16:720-8. 2010
  8. ncbi Topical bevacizumab therapy for corneal neovascularization
    John J Destafeno
    Duke University Eye Center, Erwin Road, Box 3802, Durham, NC 27710, USA
    Arch Ophthalmol 125:834-6. 2007
  9. pmc Corneal neovascularization: an anti-VEGF therapy review
    Jin Hong Chang
    Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago 60612, USA
    Surv Ophthalmol 57:415-29. 2012
  10. ncbi A potential therapeutic strategy for inhibition of corneal neovascularization with new anti-VEGF agents
    Hamid Hosseini
    Ophthalmology Department, Khalili Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
    Med Hypotheses 68:799-801. 2007

Research Grants

  1. Gene therapy in the cornea
    RAJIV RAVINDRA MOHAN; Fiscal Year: 2012
  2. The Role of Galectins in Corneal Hem- and Lymphangiogenesis
    Noorjahan Panjwani; Fiscal Year: 2013
  3. Identification and Characterization of the Mouse PPCD1 Gene
    Christopher A Bradfield; Fiscal Year: 2013
  4. Novel Angiogenesis Inhibitors Targeting the Anthrax Toxin Receptors
    MICHAEL SEAN ROGERS; Fiscal Year: 2012
  5. Endogenous Specific Inhibitor of Corneal Lymphangiogenesis
    Jayakrishna Ambati; Fiscal Year: 2013
  6. Mechanisms of anterior segment development and corneal neovascularization
    Tsutomu Kume; Fiscal Year: 2012
  7. Mechanisms of Herpetic Keratitis
    Barry T Rouse; Fiscal Year: 2013
  8. In Vivo Ocular Angiogenesis Assay
    WEN SENG; Fiscal Year: 2009
  9. Pre-mRNA Interference of VEGF Pathways in Ocular Angiogenesis
    Balamurali K Ambati; Fiscal Year: 2013
  10. Corneal Epithelial Proliferation and Neovascularization
    Sakae Ikeda; Fiscal Year: 2013

Detail Information

Publications252 found, 100 shown here

  1. pmc Corneal angiogenic privilege: angiogenic and antiangiogenic factors in corneal avascularity, vasculogenesis, and wound healing (an American Ophthalmological Society thesis)
    Dimitri T Azar
    Massachusetts Eye and Ear Infirmary and Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts, USA
    Trans Am Ophthalmol Soc 104:264-302. 2006
    ..To determine the molecular basis of corneal avascularity during wound healing and determine the role of angiogenic and antiangiogenic factors in corneal vasculogenesis...
  2. ncbi Bevacizumab as a potent inhibitor of inflammatory corneal angiogenesis and lymphangiogenesis
    Felix Bock
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 48:2545-52. 2007
    ..Bevacizumab (Avastin; Roche, Welwyn Garden City, UK) is a recombinant, humanized, monoclonal antibody against VEGF-A that has been approved by the U.S. Food and Drug Administration for the treatment of colon carcinomas...
  3. ncbi The mouse cornea micropocket angiogenesis assay
    Michael S Rogers
    The Vascular Biology Program, Children s Hospital Boston, and Department of Ophthalmology, Harvard Medical School, 300 Longwood Ave, Boston, Massachusetts 02115, USA
    Nat Protoc 2:2545-50. 2007
    ..A skilled investigator can implant and grade 40 eyes in about 2.5 h. The results of the assay are used to assess the ability of potential therapeutic molecules or genetic differences to modulate angiogenesis in vivo...
  4. ncbi Subconjunctival injection of recombinant AAV-angiostatin ameliorates alkali burn induced corneal angiogenesis
    Huey Chuan Cheng
    Department of Ophthalmology, Mackay Memorial Hospital, Taipei, Taiwan
    Mol Vis 13:2344-52. 2007
    ..To evaluate the effect of subconjunctival injection of recombinant adeno-associated virus (rAAV)-angiostatin in alkali burn-induced corneal angiogenesis...
  5. ncbi Inhibition of hemangiogenesis and lymphangiogenesis after normal-risk corneal transplantation by neutralizing VEGF promotes graft survival
    Claus Cursiefen
    Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 45:2666-73. 2004
    ..To evaluate the occurrence and time course of hem- and lymphangiogenesis after normal-risk corneal transplantation in the mouse model and to test whether pharmacologic strategies inhibiting both processes improve long-term graft survival...
  6. ncbi Comparative evaluation of FGF-2-, VEGF-A-, and VEGF-C-induced angiogenesis, lymphangiogenesis, vascular fenestrations, and permeability
    Renhai Cao
    Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
    Circ Res 94:664-70. 2004
    ..Such information is important to consider in development of novel therapeutic strategies using these angiogenic factors...
  7. pmc Localization of angiotensin converting enzyme in rabbit cornea and its role in controlling corneal angiogenesis in vivo
    Ajay Sharma
    Harry S Truman Memorial Veterans Hospital, Columbia, MO 65212, USA
    Mol Vis 16:720-8. 2010
    ....
  8. ncbi Topical bevacizumab therapy for corneal neovascularization
    John J Destafeno
    Duke University Eye Center, Erwin Road, Box 3802, Durham, NC 27710, USA
    Arch Ophthalmol 125:834-6. 2007
  9. pmc Corneal neovascularization: an anti-VEGF therapy review
    Jin Hong Chang
    Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago 60612, USA
    Surv Ophthalmol 57:415-29. 2012
    b>Corneal neovascularization is a serious condition that can lead to a profound decline in vision. The abnormal vessels block light, cause corneal scarring, compromise visual acuity, and may lead to inflammation and edema...
  10. ncbi A potential therapeutic strategy for inhibition of corneal neovascularization with new anti-VEGF agents
    Hamid Hosseini
    Ophthalmology Department, Khalili Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
    Med Hypotheses 68:799-801. 2007
    The factors triggering corneal neovascularization involve various growth factors. The data supporting a causal role for vascular endothelial growth factor (VEGF) in corneal neovascularization are extensive...
  11. pmc Inhibition of experimental corneal neovascularisation by bevacizumab (Avastin)
    Roberta P A Manzano
    Department of Ophthalmology, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
    Br J Ophthalmol 91:804-7. 2007
    ..To evaluate the effect of topically administered bevacizumab (Avastin) on experimental corneal neovascularisation in rats...
  12. ncbi Safety, penetration and efficacy of topically applied bevacizumab: evaluation of eyedrops in corneal neovascularization after chemical burn
    Efdal Yoeruek
    Department of Ophthalmology, Eberhard Karls University Tubingen, Germany
    Acta Ophthalmol 86:322-8. 2008
    ..This pilot study was designed to evaluate experimental treatment with bevacizumab eyedrops in corneal neovascularization induced by alkali burn...
  13. pmc VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment
    Claus Cursiefen
    The Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Invest 113:1040-50. 2004
    ..We conclude that VEGF-A recruitment of monocytes/macrophages plays a crucial role in inducing inflammatory neovascularization by supplying/amplifying signals essential for pathological hemangiogenesis and lymphangiogenesis...
  14. pmc Dose-dependent response of FGF-2 for lymphangiogenesis
    Lynn K Chang
    Vascular Biology Program, Department of Surgery, Children s Hospital Boston, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:11658-63. 2004
    ..e., in the absence of angiogenesis, in the mouse cornea...
  15. pmc Inhibitory effects of polysaccharide extract from Spirulina platensis on corneal neovascularization
    LingLing Yang
    State Key Laboratory Cultivation Base, Shandong Provincial Key Lab of Ophthalmology, Shandong Eye Institute, Qingdao, China
    Mol Vis 15:1951-61. 2009
    To assess the effects of polysaccharide extract from Spirulina platensis (PSP) on corneal neovascularization (CNV) in vivo and in vitro.
  16. pmc Multi-gene targeted antiangiogenic therapies for experimental corneal neovascularization
    Peng Chen
    Shandong Provincial Key Lab of Ophthalmology, Shandong Eye Institute, Qingdao, China
    Mol Vis 16:310-9. 2010
    To determine the effectiveness of multigene-based anti-angiogenic gene therapies for experimental murine corneal neovascularization (corneal NV).
  17. ncbi Subconjunctival bevacizumab injection for corneal neovascularization in recurrent pterygium
    Irit Bahar
    Department of Ophthalmology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    Curr Eye Res 33:23-8. 2008
    ..We report on the use of subconjunctival bevacizumab on corneal vessel density in recurrent pterygia...
  18. pmc Human tears reveal insights into corneal neovascularization
    Nadia Zakaria
    Department of Ophthalmology, Antwerp University Hospital, Antwerp, Belgium
    PLoS ONE 7:e36451. 2012
    b>Corneal neovascularization results from the encroachment of blood vessels from the surrounding conjunctiva onto the normally avascular cornea...
  19. ncbi The different effects of early and late bevacizumab (Avastin) injection on inhibiting corneal neovascularization and conjunctivalization in rabbit limbal insufficiency
    Chung Tien Lin
    Department of Veterinary Medicine, College of Bio Resource and Agriculture, National Taiwan University, Taipei, Taiwan
    Invest Ophthalmol Vis Sci 51:6277-85. 2010
    To compare the effects of early, mid, and late subconjunctival injection of bevacizumab on corneal neovascularization (NV) and conjunctivalization in a rabbit limbal insufficiency model.
  20. pmc Semaphorin 7A promotes angiogenesis in an experimental corneal neovascularization model
    Ramon C Ghanem
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, USA
    Curr Eye Res 36:989-96. 2011
    To characterize the involvement of Semaphorin 7A (Sema7a) in corneal neovascularization (NV).
  21. pmc Pericyte recruitment in human corneal angiogenesis: an ultrastructural study with clinicopathological correlation
    C Cursiefen
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Br J Ophthalmol 87:101-6. 2003
    ..This study analyses whether, and if so when, pathological vessels in human corneal neovascularisation (CN) acquire pericyte coverage. This can be of importance for future angioregressive therapeutic strategies...
  22. ncbi Corneal neovascularization as a risk factor for graft failure and rejection after keratoplasty: an evidence-based meta-analysis
    Bjorn Bachmann
    Department of Ophthalmology, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    Ophthalmology 117:1300-5.e7. 2010
    Preoperative corneal neovascularization (CNV) is thought to be associated with an increased rate of corneal graft failure and potentially also graft rejection.
  23. ncbi Treatment of inflamed pterygia or residual pterygial bed
    A M Mansour
    Department of Ophthalmology, American University of Beirut, PO Box 113 6044, Beirut, Lebanon
    Br J Ophthalmol 93:864-5. 2009
    ..To describe the use of subconjunctival bevacizumab or ranibizumab, an approved antivascular endothelial growth factor for wet macular degeneration, in halting the inflammation of a pterygium or a partially excised pterygium...
  24. pmc Inhibition of VEGF expression and corneal neovascularization by shRNA targeting HIF-1α in a mouse model of closed eye contact lens wear
    Peng Chen
    Qingdao University Medical College, Qingdao, China
    Mol Vis 18:864-73. 2012
    Inappropriate contact lens (CL) use and care often lead to corneal neovascularization (corneal NV). We used mouse eyes which wore CL as the animal model to assess the reason for corneal NV with CL wear...
  25. ncbi Matrix revolution: molecular mechanism for inflammatory corneal neovascularization and restoration of corneal avascularity by epithelial stem cell transplantation
    David Hui Kang Ma
    Limbal Stem Cell Laboratory, Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Ocul Surf 7:128-44. 2009
    b>Corneal neovascularization (CNV) associated with severe limbal stem cell (LSC) deficiency remains a challenging ocular surface disease in that corneal inflammation may persist and progress, and the condition will not improve without LSC ..
  26. ncbi Photodynamic therapy with verteporfin for corneal neovascularization
    Kyung Chul Yoon
    Department of Ophthalmology, Chonnam National University Medical School and Hospital, Gwangju, Korea
    Am J Ophthalmol 144:390-395. 2007
    To investigate the efficacy of photodynamic therapy with verteporfin for the treatment of patients with corneal neovascularization.
  27. ncbi The role of PDGF receptor inhibitors and PI3-kinase signaling in the pathogenesis of corneal neovascularization
    Susanne Dell
    Department of Vitreoretinal Surgery, Center for Ophthalmology, University of Cologne, Cologne, Germany
    Invest Ophthalmol Vis Sci 47:1928-37. 2006
    b>Corneal neovascularization remains an unsolved therapeutic problem. Platelet-derived growth factor (PDGF) is directly linked to vessel formation and stabilization...
  28. pmc Effects of topical and subconjunctival bevacizumab in high-risk corneal transplant survival
    Mohammad H Dastjerdi
    Schepens Eye Research Institute, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 51:2411-7. 2010
    ..To investigate whether corneal graft survival could be improved by topical or subconjunctival bevacizumab in a murine model of vascularized high-risk corneal transplantation...
  29. ncbi Subconjunctival injection of bevacizumab in the treatment of corneal neovascularization associated with lipid deposition
    Hsiao Sang Chu
    Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan
    Cornea 30:60-6. 2011
    To determine the effects on corneal neovascularization (NV) and lipid deposition after subconjunctival injection of bevacizumab in patients who had NV associated with lipid keratopathy.
  30. ncbi Photodynamic therapy with verteporfin combined with subconjunctival injection of bevacizumab for corneal neovascularization
    In Cheon You
    Department of Ophthalmology, Chonnam National University Medical School and Hospital, Gwangju, Korea
    Cornea 30:30-3. 2011
    To investigate the efficacy of combined photodynamic therapy with verteporfin and subconjunctival injection of bevacizumab for the treatment of patients with corneal neovascularization.
  31. ncbi Subconjunctival and intracorneal bevacizumab injection for corneal neovascularization in lipid keratopathy
    Joo Youn Oh
    Department of Ophthalmology, Seoul National University College of Medicine, Seoul 110 744, Korea
    Cornea 28:1070-3. 2009
    The purpose of this study was to evaluate the efficacy and safety of subconjunctival and corneal intrastromal bevacizumab injections on corneal neovascularization in patients with lipid keratopathy.
  32. pmc Celastrol nanoparticles inhibit corneal neovascularization induced by suturing in rats
    Zhanrong Li
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, People s Republic of China
    Int J Nanomedicine 7:1163-73. 2012
    ..However, the poor water solubility of celastrol restricts its further application. This paper aims to study the effect of celastrol nanoparticles (CNPs) on corneal neovascularization (CNV) and determine the possible mechanism.
  33. pmc Nanoparticle-mediated delivery of shRNA.VEGF-a plasmids regresses corneal neovascularization
    Yureeda Qazi
    John A Moran Eye Center, Salt Lake City, UT 84132, USA
    Invest Ophthalmol Vis Sci 53:2837-44. 2012
    ..shRNA) against VEGF-A-loaded poly(lactic co-glycolic acid) nanoparticles (PLGA NPs) in the sustained regression of murine corneal neovascularization.
  34. pmc Dexamethasone inhibits interleukin-1beta-induced corneal neovascularization: role of nuclear factor-kappaB-activated stromal cells in inflammatory angiogenesis
    Shintaro Nakao
    Department of Ophthalmology, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Am J Pathol 171:1058-65. 2007
    ....
  35. ncbi Diminished corneal angiogenesis in gelatinase A-deficient mice
    T Kato
    The Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    FEBS Lett 508:187-90. 2001
    ..26+/-0.14 mm(2)) as compared to wild-type littermates (0.44+/-0.06 mm(2); P<0.05). These results suggest that gelatinase A may play an important role in the regulation of corneal angiogenesis...
  36. pmc S100A proteins in the pathogenesis of experimental corneal neovascularization
    Changyou Li
    Qingdao University SEI Joint Ophthalmology Program, Qingdao, China
    Mol Vis 16:2225-35. 2010
    ..Two of its members, S100A4 and A13, are thought to be pro-angiogenic in tumor development. This study examines whether S100A proteins are involved in the pathogenesis of inflammation-associated corneal neovascularization (CorNV).
  37. pmc EphA2/Ephrin-A1 signaling complexes restrict corneal epithelial cell migration
    Nihal Kaplan
    Department of Dermatology, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Chicago, IL 60611, USA
    Invest Ophthalmol Vis Sci 53:936-45. 2012
    ..Eph/ephrin signaling proteins are present in the corneal epithelium, where their function remains unknown. The authors examined the role of the EphA2 receptor and ephrin-A1 ligand in human corneal epithelial cell migration...
  38. ncbi Suramab, a novel antiangiogenic agent, reduces tumor growth and corneal neovascularization
    Emiliano S Lopez
    Departments of Ophthalmology and Internal Medicine, Austral University Medical School and Austral University Hospital, Pilar, Buenos Aires, Argentina
    Cancer Chemother Pharmacol 67:723-8. 2011
    ..Our purpose was to evaluate the synergistic effect of two drugs, jointly administered as a pharmaceutical compound, in two animal models...
  39. ncbi Photodynamic therapy of corneal neovascularization with verteporfin
    Maurizio Fossarello
    Department of Surgical Sciences, Eye Clinic, University of Cagliari, Italy
    Cornea 22:485-8. 2003
    To describe the effect of photodynamic therapy (PDT) using verteporfin (Visudyne) on corneal neovascularization (CNV) in two patients.
  40. ncbi Inhibition of corneal neovascularization with endostatin delivered by adeno-associated viral (AAV) vector in a mouse corneal injury model
    Li Ju Lai
    Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Kwei San, Tao Yuan, 333, Taiwan
    J Biomed Sci 14:313-22. 2007
    ..adeno-associated viral (rAAV) vector carrying endostatin gene as an anti-angiogenesis strategy to treat corneal neovascularization in a mouse model was evaluated...
  41. pmc The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin
    Paola Bargagna-Mohan
    Department of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, KY 40536, USA
    Chem Biol 14:623-34. 2007
    ..Finally, we show that WFA-induced inhibition of capillary growth in a mouse model of corneal neovascularization is compromised in vimentin-deficient mice...
  42. ncbi Time course of angiogenesis and lymphangiogenesis after brief corneal inflammation
    Claus Cursiefen
    Department of Ophthalmology, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    Cornea 25:443-7. 2006
    ..To study the time course of angiogenesis and lymphangiogenesis in the cornea after a short inflammatory insult. This might be helpful for the timing of corneal transplantation in high-risk eyes...
  43. ncbi The effect of subconjunctival suramin on corneal neovascularization in rabbits
    Hyun Soo Lee
    Laboratory of Visual Science, St Mary s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Cornea 29:86-92. 2010
    To evaluate the effect of subconjunctival injection of suramin on corneal neovascularization in rabbits.
  44. ncbi Cellular-level characterization of lymph vessels in live, unlabeled corneas by in vivo confocal microscopy
    Beatrice Bourghardt Peebo
    Department of Ophthalmology, Linkoping University Hospital, Linkoping, Sweden
    Invest Ophthalmol Vis Sci 51:830-5. 2010
    ..To determine whether in vivo confocal microscopy (IVCM) of the cornea can be used for the label-free detection and monitoring of lymph vessels in live corneas...
  45. ncbi Opposite roles of CCR2 and CX3CR1 macrophages in alkali-induced corneal neovascularization
    Peirong Lu
    Department of Ophthalmology, Clinical Immunology Key Laboratory of Jiangsu Province, The First Affiliated Hospital of Soochow University, Suzhou, China
    Cornea 28:562-9. 2009
    The purpose of this study was to investigate the role of infiltrating macrophages in the development of experimental corneal neovascularization.
  46. ncbi Bevacizumab (Avastin) eye drops inhibit corneal neovascularization
    Felix Bock
    Department of Ophthalmology, Friedrich Alexander University Erlangen Nurnberg, Schwabachanlage 6, Erlangen, Germany
    Graefes Arch Clin Exp Ophthalmol 246:281-4. 2008
    To analyze the ability of bevacizumab (Avastin) eye drops to inhibit corneal neovascularization.
  47. pmc Genetic heterogeneity of lymphangiogenesis in different mouse strains
    Birgit Regenfuss
    Department of Ophthalmology, Friedrich Alexander University Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Am J Pathol 177:501-10. 2010
    ..Using the mouse cornea micropocket assay (VEGF-C) and the suture-induced corneal neovascularization model in different inbred and wild-derived mouse strains (Balb/cAnNCrl, C57BL/6NCrl, 129S1/SvImJ, SJL/..
  48. ncbi The effect of doxycycline temperature-sensitive hydrogel on inhibiting the corneal neovascularization induced by BFGF in rats
    Wenru Su
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, 54 Xianlie South Road, Guangzhou, 510060, China
    Graefes Arch Clin Exp Ophthalmol 249:421-7. 2011
    To study the effect of doxycycline temperature-sensitive hydrogel (DTSH) on inhibiting the corneal neovascularization (NV) induced by the basic fibroblast growth factor (bFGF).
  49. pmc Mediators of ocular angiogenesis
    Yureeda Qazi
    Department of Ophthalmology, John Moran Eye Center, University of Utah, Salt Lake City, UT 84132, USA
    J Genet 88:495-515. 2009
    ....
  50. ncbi Corneal graft surgery combined with subconjunctival bevacizumab (avastin)
    Richard J Symes
    Department of Ophthalmology, Frimley Park Hospital, Camberley, Surrey, United Kingdom
    Cornea 29:691-3. 2010
    ..To describe the use of subconjunctival bevacizumab (Avastin) as an adjunctive treatment in a vascularized cornea at the time of lamellar keratoplasty to reduce the risk of graft rejection...
  51. ncbi Anti-VEGF monoclonal antibody-induced regression of corneal neovascularization and inflammation in a rabbit model of herpetic stromal keratitis
    Mario Saravia
    Laboratory of Investigation in Ophthalmology, Department of Pathology, School of Medicine, University of Buenos Aires, J E Uriburu 950, Buenos Aires, Argentina
    Graefes Arch Clin Exp Ophthalmol 247:1409-16. 2009
    ..To determine the efficacy of bevacizumab (Avastin), an anti-VEGF monoclonal antibody, administrated via subconjunctival injection as a corneal anti-angiogenic treatment...
  52. pmc Trehalose 6,6'-dimycolate (cord factor) of Mycobacterium tuberculosis induces corneal angiogenesis in rats
    N Saita
    Department of Host Defense, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Infect Immun 68:5991-7. 2000
    ..Treatment with anti-TNF-alpha antibodies resulted in partial inhibition. TDM possesses pleiotropic activities, and the cytokine network plays an important role in the process of neovascularization...
  53. ncbi Inhibition of angiogenesis by adenovirus-mediated sFlt-1 expression in a rat model of corneal neovascularization
    C M Lai
    Centre for Ophthalmology and Visual Science, University of Western Australia, Nedlands, Western Australia 6009, Australia
    Hum Gene Ther 12:1299-310. 2001
    ..the anterior chamber is sufficient to inhibit new vessel formation in the cornea in an animal model of corneal neovascularization. A recombinant adenovirus vector that can mediate efficient in vivo gene transfer and expression in ..
  54. ncbi Neutrophils promote inflammatory angiogenesis via release of preformed VEGF in an in vivo corneal model
    Yue Gong
    Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Blk MD9, 2 Medical Drive, Singapore 117597, Singapore
    Cell Tissue Res 339:437-48. 2010
    ..Intervention measures targeting neutrophils may therefore help to deal with abnormal angiogenesis involved in chronic inflammatory diseases...
  55. ncbi Short- and long-term safety profile and efficacy of topical bevacizumab (Avastin) eye drops against corneal neovascularization
    Yanyan Koenig
    Department of Ophthalmology, Friedrich Alexander University Erlangen Nurnberg, Schwabachanlage 6, Erlangen, Germany
    Graefes Arch Clin Exp Ophthalmol 247:1375-82. 2009
    To evaluate the short- and long-term in vivo safety and efficacy of topical bevacizumab (Avastin) application for treatment of corneal neovascularization secondary to a variety of corneal diseases.
  56. pmc Anti-angiogenesis effect of the novel anti-inflammatory and pro-resolving lipid mediators
    Yiping Jin
    Department of Ophthalmology, Schepens Eye Research Institute, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 50:4743-52. 2009
    ..Here the authors investigated the potential of aspirin-triggered lipoxin (LX) A4 analog (ATLa), resolving (Rv) D1, and RvE1, in regulating angiogenesis in a murine model...
  57. ncbi Inhibition of corneal neovascularization by a peroxisome proliferator-activated receptor-gamma ligand
    Melvin A Sarayba
    Department of Ophthalmology, University of California, 118 Med Surge I, Irvine, CA 92697 4375, USA
    Exp Eye Res 80:435-42. 2005
    To determine the efficacy of the peroxisome proliferator-activated receptor gamma agonist, pioglitazone, in inhibiting corneal neovascularization.
  58. ncbi Roles of thrombospondin-1 and -2 in regulating corneal and iris angiogenesis
    Claus Cursiefen
    Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 45:1117-24. 2004
    ..This study was undertaken to investigate whether deficiencies of these factors altered developmental and inflammation-induced angiogenesis in the cornea and developmental angiogenesis of the iris of mice...
  59. ncbi Rapid ocular angiogenic control via naked DNA delivery to cornea
    S U Stechschulte
    The Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 42:1975-9. 2001
    ..of plasmid containing the cDNA for the soluble form of the VEGF receptor Flt-1 effectively prevented corneal neovascularization. CONCLUSIONS: The cornea is readily accessible for gene therapy in the laboratory and in the clinic...
  60. ncbi Vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 in the regulation of corneal neovascularization and wound healing
    Lisha Gan
    Department of Ophthalmology, University Hospital, Linkoping, Sweden
    Acta Ophthalmol Scand 82:557-63. 2004
    ..The influence of different cells on VEGF and VEGFR-2 expression was studied by excluding granulocytes from the wound area...
  61. ncbi Loss and restoration of immune privilege in eyes with corneal neovascularization
    M R Dana
    Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 37:2485-94. 1996
    To delineate the time course for loss of immune privilege after induction of corneal neovascularization (NV), and to test whether treatment with angiostatic agents can restore the eye's capacity to induce anterior chamber-associated ..
  62. ncbi Effect of subconjunctival bevacizumab (Avastin) on experimental corneal neovascularization in guinea pigs
    Volkan Hurmeric
    Gulhane Military Medical Academy, Ankara, Turkey
    Cornea 27:357-62. 2008
    To evaluate the effect of subconjunctival bevacizumab (Avastin) on experimental corneal neovascularization in guinea pigs.
  63. ncbi Bevacizumab inhibits corneal neovascularization in an alkali burn induced model of corneal angiogenesis
    Hamid Hosseini
    Shiraz University of Medical Sciences, Department of Ophthalmology, Khalili Hospital, Shiraz, Iran
    Clin Experiment Ophthalmol 35:745-8. 2007
    ..The data supporting a causal role for vascular endothelial growth factor in corneal neovascularization are extensive...
  64. ncbi Inhibition of corneal neovascularization by recombinant adenovirus mediated antisense VEGF RNA
    Chooi May Lai
    Centre for Ophthalmology and Vision Science, The University of Western Australia, Perth, Australia
    Exp Eye Res 75:625-34. 2002
    ..relevant antisense RNA to reduce vascular endothelial growth factor expression in a rat model of corneal neovascularization. Recombinant adenovirus constructs expressing short and long antisense and sense vascular endothelial ..
  65. pmc Lymphangiogenesis and angiogenesis: concurrence and/or dependence? Studies in inbred mouse strains
    Shintaro Nakao
    Department of Ophthalmology, Harvard Medical School, and Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA
    FASEB J 24:504-13. 2010
    ..Furthermore, we show strain-dependence of normal and GF-induced lymphangiogenesis. These differences may affect disease development in various strains...
  66. pmc KH906, a recombinant human VEGF receptor fusion protein, is a new effective topical treatment for corneal neovascularization
    Tao Li
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center of Sun Yat sen University, Guangzhou 510060, China
    Mol Vis 17:797-803. 2011
    The purpose of the current study was to investigate the effect of topical administration of KH906 on corneal neovascularization (NV).
  67. pmc Inhibition of mouse alkali burn induced-corneal neovascularization by recombinant adenovirus encoding human vasohibin-1
    Shi you Zhou
    Zhongshan Ophthalmic Center, Sun Yat Sen University, The State Key Laboratory of Ophthalmology, Guangzhou, China
    Mol Vis 16:1389-98. 2010
    ..To evaluate the activity of recombinant adenovirus encoding human vasohibin-1 (Ad-Vasohibin-1) on mouse corneal neovasularization induced by alkali burn...
  68. ncbi Topical bevacizumab and ocular surface neovascularization in patients with stevens-johnson syndrome
    Harvey S Uy
    Asian Eye Institute, Makati, Philippines
    Cornea 27:70-3. 2008
    ..To evaluate the efficacy and safety of topical bevacizumab on ocular surface neovascularization among patients with Stevens-Johnson syndrome...
  69. ncbi Subconjunctival bevacizumab for corneal neovascularization
    Priyanka P Doctor
    Ocular Immunology and Uveitis Foundation, Massachusetts Eye Research and Surgery Institute, Harvard Medical School, Cambridge, MA 02142, USA
    Cornea 27:992-5. 2008
    To describe whether subconjunctival bevacizumab decreases corneal neovascularization in patients with ocular surface inflammatory diseases.
  70. ncbi Inhibition of inflammatory corneal angiogenesis by TNP-470
    A M Joussen
    Department of Vitreoretinal Surgery, Center for Ophthalmology, University of Cologne, Koln, Germany
    Invest Ophthalmol Vis Sci 42:2510-6. 2001
    To determine the efficacy of the angiogenic inhibitor TNP-470 on inflammatory corneal neovascularization. Topical and systemic delivery of the drug were investigated in a murine model as well as inhibition of endothelial cell ..
  71. pmc Contribution of vascular endothelial growth factor in the neovascularization process during the pathogenesis of herpetic stromal keratitis
    M Zheng
    Department of Microbiology, University of Tennessee, Knoxville, Tennessee 37996, USA
    J Virol 75:9828-35. 2001
    ..Our results indicate that the control of angiogenesis represents a useful adjunct to therapy of herpetic ocular disease, an important cause of human blindness...
  72. ncbi The anti-inflammatory effect of subconjunctival bevacizumab on chemically burned rat corneas
    Joo Youn Oh
    Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea
    Curr Eye Res 34:85-91. 2009
    ..To investigate the effect of bevacizumab in a model of corneal inflammation...
  73. pmc The effect of bevacizumab versus ranibizumab in the treatment of corneal neovascularization: a preliminary study
    Jin Hyoung Kim
    Department of Ophthalmology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea
    Korean J Ophthalmol 27:235-42. 2013
    To compare the short term effects of bevacizumab and ranibizumab injections on the regression of corneal neovascularization (NV).
  74. ncbi Photodynamic therapy for corneal neovascularization using polymeric micelles encapsulating dendrimer porphyrins
    Kenji Sugisaki
    Department of Ophthalmology, Faculty of Medicine, University of Tokyo, Hongo, Bunkyo ku, Japan
    Invest Ophthalmol Vis Sci 49:894-9. 2008
    ..of new photosensitizers (PSs), dendrimer porphyrin (DP, free DP), and DP encapsulation into polymeric micelles (DP-micelle) and the efficacy of photodynamic therapy (PDT) in an experimental corneal neovascularization model in mice.
  75. ncbi Ocular neovascularization: Implication of endogenous angiogenic inhibitors and potential therapy
    Sarah X Zhang
    Department of Medicine Endocrinology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Prog Retin Eye Res 26:1-37. 2007
    ..This article reviews recent progress in studies on the mechanisms and treatment of ocular NV, focusing on the implication and therapeutic potential of endogenous angiogenic inhibitors in ocular NV...
  76. ncbi Prevention of corneal neovascularization: comparison of different doses of subconjunctival bevacizumab with its topical form in experimental rats
    Mohammad Naser Hashemian
    Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran
    Ophthalmic Res 46:50-4. 2011
    To compare the effect of different dosages of subconjunctival bevacizumab with its topical administration on preventing the development of corneal neovascularization (CNV) in a rat model of corneal chemical injury.
  77. ncbi Simultaneous but not prior inhibition of VEGF165 enhances the efficacy of photodynamic therapy in multiple models of ocular neovascularization
    Meihua Ju
    OSI Eyetech Pharmaceuticals, Farmingdale, NY, USA
    Invest Ophthalmol Vis Sci 49:662-70. 2008
    ..To investigate the effect of the combined treatment of photodynamic therapy and specific VEGF165 inhibition with pegaptanib sodium (Macugen; Eyetech Pharmaceuticals, Lexington, MA) on ocular neovascularization...
  78. ncbi Subconjunctival bevacizumab for vascularized rejected corneal grafts
    Ahmed Awadein
    Cairo University School of Medicine, Cairo, Egypt
    J Cataract Refract Surg 33:1991-3. 2007
    We describe 3 patients who experienced corneal neovascularization following keratoplasty and were treated with a single subconjunctival injection of 2.5 mg bevacizumab...
  79. ncbi Combined use of subconjunctival and intracorneal bevacizumab injection for corneal neovascularization
    Sonia N Yeung
    Department of Ophthalmology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    Cornea 30:1110-4. 2011
    To report on the safety and clinical use of combined subconjunctival and intracorneal bevacizumab for corneal neovascularization.
  80. ncbi Systemic soluble Tie2 expression inhibits and regresses corneal neovascularization
    Nirbhai Singh
    Department of Ophthalmology, Medical College of Georgia, Augusta, GA, USA
    Biochem Biophys Res Commun 332:194-9. 2005
    This study was designed to determine if soluble Tie2 (sTie2) expression inhibits and regresses corneal neovascularization, and if VEGF contributes to its effect...
  81. ncbi Doxycycline enhances the inhibitory effects of bevacizumab on corneal neovascularization and prevents its side effects
    Wenru Su
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, 54 XianlieSouth Road, Guangzhou, China
    Invest Ophthalmol Vis Sci 52:9108-15. 2011
    ..therapeutic effects of topical doxycycline temperature-sensitive hydrogel (DTSH) and bevacizumab on corneal neovascularization (CNV) and corneal wound healing (CWH) and to explore the underlying mechanisms of doxycycline on CNV and ..
  82. ncbi Gene transfer of kringle 5 of plasminogen by electroporation inhibits corneal neovascularization
    Wen Zhen Yu
    Department of Ophthalmology, Peking University People s Hospital, Beijing, China
    Ophthalmic Res 35:239-46. 2003
    To test the efficacy of naked plasmid that expresses human kringle 5 of plasminogen (K5) in suppressing experimental corneal neovascularization in a rat model.
  83. ncbi Treatment parameters for selective occlusion of experimental corneal neovascularization by photodynamic therapy using a water soluble photosensitizer, ATX-S10(Na)
    Y Gohto
    Department of Ophthalmology, Osaka City University Medical School, Abenoku, Osaka, Japan
    Exp Eye Res 72:13-22. 2001
    Time dependent change of an accumulation of an amphiphilic photosensitizer, ATX-S10(Na) on rabbit corneal neovascularization (CoNV) was evaluated by angiography using ATX-S10(Na) as a fluorescent dye on three rabbits...
  84. pmc Topical ranibizumab as a treatment of corneal neovascularization
    Giulio Ferrari
    G B Bietti Eye Foundation IRCCS, Rome, Italy
    Cornea 32:992-7. 2013
    To examine the effect of topical ranibizumab on clinically stable corneal neovascularization (NV).
  85. pmc Activin a in the regulation of corneal neovascularization and vascular endothelial growth factor expression
    Vassiliki Poulaki
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, and the Dana Faber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
    Am J Pathol 164:1293-302. 2004
    ..We examined the role of activin A and its downstream signaling pathway in a murine model of inflammatory corneal neovascularization induced by mechanical injury (debridement), and in vitro in corneal epithelial cells...
  86. ncbi Corneal neovascularization
    J H Chang
    Schepens Eye Research Institute and the Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Curr Opin Ophthalmol 12:242-9. 2001
    b>Corneal neovascularization (NV) is a sight-threatening condition usually associated with inflammatory or infectious disorders of the ocular surface...
  87. ncbi Critical role of TNF-α-induced macrophage VEGF and iNOS production in the experimental corneal neovascularization
    Peirong Lu
    Department of Ophthalmology, The First Affiliated Hospital of Soochow University, Suzhou City, China
    Invest Ophthalmol Vis Sci 53:3516-26. 2012
    We evaluated the roles of tumor necrosis factor (TNF)-α in alkali-induced corneal neovascularization (CNV).
  88. ncbi The artemisinin derivative artesunate inhibits corneal neovascularization by inducing ROS-dependent apoptosis in vascular endothelial cells
    Rui Cheng
    Department of Biochemistry, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, China
    Invest Ophthalmol Vis Sci 54:3400-9. 2013
    Without therapeutic intervention, corneal neovascularization rapidly compromises visual acuity, and is a leading cause of blindness...
  89. pmc Pharmacologic uncoupling of angiogenesis and inflammation during initiation of pathological corneal neovascularization
    Jeremy M Sivak
    Department of Vision Sciences, Toronto Western Hospital, Toronto, Ontario M5T 2S8, Canada
    J Biol Chem 286:44965-75. 2011
    ..We present data from an epithelial debridement model of corneal neovascularization describing an initial 3-day period when a substantial component of neovascular growth occurs...
  90. ncbi Corn1: a mouse model for corneal surface disease and neovascularization
    R S Smith
    Jackson Laboratory, Bar Harbor, Maine 04609 1500, USA
    Invest Ophthalmol Vis Sci 37:397-404. 1996
    ..To describe a new mouse model of corneal surface disease and neovascularization...
  91. pmc Corneal neovascularization and the utility of topical VEGF inhibition: ranibizumab (Lucentis) vs bevacizumab (Avastin)
    William Stevenson
    Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Ocul Surf 10:67-83. 2012
    ..The clinical relevance of corneal neovascularization has long been recognized, but management of this condition has been hindered by a lack of safe and ..
  92. ncbi Photodynamic therapy with verteporfin in a rabbit model of corneal neovascularization
    Mike P Holzer
    Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Invest Ophthalmol Vis Sci 44:2954-8. 2003
    To determine the efficacy of photodynamic therapy (PDT) with verteporfin (Visudyne; Novartis AG, Basel, Switzerland) for treatment of corneal neovascularization in a rabbit eye model.
  93. ncbi Suppression of corneal neovascularization by culture supernatant of human amniotic cells
    Namie Kobayashi
    Department of Biomolecular Science, Fukushima Medical University School of Medicine, Japan
    Cornea 21:62-7. 2002
    To examine the applicability of culture supernatant of human amniotic cells on basic fibroblast growth factor (bFGF)-induced corneal neovascularization.
  94. ncbi VEGF-dependent conjunctivalization of the corneal surface
    Antonia M Joussen
    Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA
    Invest Ophthalmol Vis Sci 44:117-23. 2003
    To investigate the mechanisms governing corneal neovascularization and the appearance of goblet cells in a murine model of limbal insufficiency.
  95. ncbi Treatment of corneal neovascularization with dietary isoflavonoids and flavonoids
    A M Joussen
    Department of Ophthalmology, University of Aachen RWTH, Aachen, Germany
    Exp Eye Res 71:483-7. 2000
    ..5 and 1 ng ml(-1). Corneal neovascularization was quantified under the microscope...
  96. ncbi The effect of topical infliximab on corneal neovascularization in rabbits
    Jae Woo Kim
    Department of Ophthalmology and Visual Science, St Mary s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Cornea 32:185-90. 2013
    To determine the efficacy of topical application of infliximab [tumor necrosis factor-α (TNF-α) monoclonal antibody] for the treatment of corneal neovascularization in the rabbit model.
  97. ncbi Anti-VEGF Treatment of Corneal Neovascularization
    Anne M Keating
    Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, USA
    Ocul Surf 9:227-37. 2011
    ..The experience of one clinician with the use of an anti-VEGF drug in the treatment of active corneal NV is presented...
  98. pmc Photodynamic therapy for corneal neovascularisation and lipid degeneration
    B J Brooks
    Br J Ophthalmol 88:840. 2004
  99. ncbi Survival of mushroom keratoplasty performed in corneas with postinfectious vascularized scars
    Vincenzo Scorcia
    Department of Ophthalmology, Casa di Cura Villa Igea, Forli, Italy
    Am J Ophthalmol 153:44-50.e1. 2012
    ..To report the visual outcomes and graft survival rates of mushroom keratoplasty for the treatment of postinfectious corneal scars...
  100. ncbi Anti-angiogenic role of angiostatin during corneal wound healing
    Eric Gabison
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, and the Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA
    Exp Eye Res 78:579-89. 2004
    ..artery endothelial (CPAE) cell proliferation assay with and without angiostatin immunoprecipitation; and corneal neovascularization was assayed by intrastromal injection of anti-plasminogen, anti-K1-3 or anti-B chain antibodies after ..
  101. ncbi Combined use of superficial keratectomy and subconjunctival bevacizumab injection for corneal neovascularization
    Cynthia Xin ya Qian
    Department of Ophthalmology, University of Montreal, Montreal, Quebec, Canada
    Cornea 27:1090-2. 2008
    To report the effect of superficial keratectomy combined with subconjunctival bevacizumab injection in 2 cases of corneal neovascularization (NV).

Research Grants51

  1. Gene therapy in the cornea
    RAJIV RAVINDRA MOHAN; Fiscal Year: 2012
    ..that tissue-selective AAV-PEDF gene therapy delivered into rabbit keratocytes in vivo inhibits corneal neovascularization in rabbits without significant adverse effects...
  2. The Role of Galectins in Corneal Hem- and Lymphangiogenesis
    Noorjahan Panjwani; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Corneal neovascularization is a vision-threatening condition affecting ~1.4 million individuals each year in the United States alone...
  3. Identification and Characterization of the Mouse PPCD1 Gene
    Christopher A Bradfield; Fiscal Year: 2013
    ..Secondary phenotypes observed in PPCD1 mice include corneal neovascularization, retinal ganglion cell loss, and photoreceptor loss, all significant causes of blindness in humans...
  4. Novel Angiogenesis Inhibitors Targeting the Anthrax Toxin Receptors
    MICHAEL SEAN ROGERS; Fiscal Year: 2012
    ..We have discovered that anthrax protective antigen mutants (e.g. PASSSR) can powerfully suppress corneal neovascularization induced by multiple growth factors...
  5. Endogenous Specific Inhibitor of Corneal Lymphangiogenesis
    Jayakrishna Ambati; Fiscal Year: 2013
    ..Numerous pathological disorders result in corneal neovascularization that is responsible for blindness in hundreds of millions of individuals worldwide...
  6. Mechanisms of anterior segment development and corneal neovascularization
    Tsutomu Kume; Fiscal Year: 2012
    ..abstract_text> ..
  7. Mechanisms of Herpetic Keratitis
    Barry T Rouse; Fiscal Year: 2013
    ..initiate the influx of inflammatory cells to the stroma, b) counteract the development and extent of corneal neovascularization (CV) that both facilitates inflammatory cell entrance and also contributes to visual impairment and c) ..
  8. In Vivo Ocular Angiogenesis Assay
    WEN SENG; Fiscal Year: 2009
    ..Another cause of blindness is corneal neovascularization, which often results from injury and infection in the cornea...
  9. Pre-mRNA Interference of VEGF Pathways in Ocular Angiogenesis
    Balamurali K Ambati; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Relevance to Veterans'Health: Corneal neovascularization is a sight-threatening complication of ocular injury, from shrapnel, improvised explosive devices (IEDs),..
  10. Corneal Epithelial Proliferation and Neovascularization
    Sakae Ikeda; Fiscal Year: 2013
    ..mutation develop a roughened, opaque corneal surface caused by hyperproliferation, and subsequent corneal neovascularization. We previously determined that deletion of destrin (Dstn), a major regulator of actin dynamics, is ..
  11. The Role of Extracelluar Enzymes in Regulating Corneal Repair
    Matilda Frances Chan; Fiscal Year: 2012
    ..various growth factors, particularly TGF-p2 and FGF, are critical to the corneal fibrotic phenotype and corneal neovascularization. Taken together, these extracellular enzymes may regulate various aspects of the repair process, both ..
  12. A New Model for Eye Disease
    WEN SENG; Fiscal Year: 2009
    ..Another cause of blindness is corneal neovascularization, which often results from injury and infection in the cornea...
  13. The Role of Soluble Flt-1 and Raver2 in Ocular Vascular Demarcations
    Balamurali K Ambati; Fiscal Year: 2013
    ..Morpholinos (synthetic morpholine-based oligonucleotides) upregulating sFlt-1 suppressed suture-induced corneal neovascularization and laser-induced choroidal neovascularization, and improve cornea transplant survival...
  14. Neovascularization Patterns in Corneal Graft Rejection
    RONI MINTZ SHTEIN; Fiscal Year: 2011
    b>Corneal neovascularization (CN) is an established risk factor for corneal allograft rejection and failure...
  15. New Strategies for Modulation of Corneal and Ocular Surface Inflammation
    Reza Dana; Fiscal Year: 2012
    ..Novel anti-cytokine strategies for management of ocular surface inflammation and corneal neovascularization (NV), wherein we propose to test molecular targeting strategies against specific cytokines known to be ..
  16. METALLOPROTEINASE EXPRESSION IN CORNEAL WOUNDS
    Dimitri T Azar; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Corneal neovascularization (NV) is a major cause of blindness worldwide...
  17. VEGFR2 Modulates Corneal Angiogenesis and Lymphangiogenesis
    Jin Hong Chang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Corneal neovascularization (NV) is a common, disabling condition and a major cause of blindness that can follow corneal injury or infection...
  18. Regulation of Corneal Repair by Metalloproteinases
    Matilda Frances Chan; Fiscal Year: 2013
    ..of expression of CCL2 and CCR2;(2) to determine the interplay of MMP12 and CCL2 in the regulation of corneal neovascularization;and (3) to characterize MMP12 expression and activity levels in patient corneal samples...
  19. MECHANISMS OF RADIATION SUPPRESSED CORNEAL ANGIOGENESIS
    MARK SCROGGS; Fiscal Year: 1991
    ..The progression of corneal neovascularization in experimental animals involves many distinct phases which can be broadly divided into: 1) a ..
  20. Role of Corneal Lymphangiogenesis in Alloimmunity
    Lu Chen; Fiscal Year: 2005
    ..our preliminary data have shown its increased expression on both lymphatics and APCs during inflammatory corneal neovascularization (NV)...
  21. Inhibition of corneal graft rejection by antioxidants
    Georges Tocco; Fiscal Year: 2003
    ..g: i) preservation of tissue before transplantation, ii) corneal neovascularization, iii) inflammation/immune rejection...
  22. HIGH PERMEABILITY, LONG WEAR CONTACT LENS MATERIALS
    Stuart Nemser; Fiscal Year: 1999
    ..corneal hypoxia) has been shown to cause stromal and epithelial edema, ulcerative keratitis and corneal neovascularization, as well as other complications...
  23. Collagen XVIII in Corneal Neovascularization
    Jin Hong Chang; Fiscal Year: 2006
    Background: Corneal neovascularization is a major cause of blindness worldwide. The objective of our research is to identify the role of collagen XVIII and its proteolytic fragments in corneal neovascularization...
  24. Signaling Pathway in Corneal Angiogenesis
    Erich Strauss; Fiscal Year: 2007
    Inflammatory corneal neovascularization results if1devastating impairment of visual function. Previous studies have provided insights into the multistep process of angiogenesis...
  25. IMMUNOBIOLOGY OF HIGH RISK CORNEAL TRANSPLANTATION
    Reza Dana; Fiscal Year: 1999
    ..factors that account for the loss of the anterior segment's normal state of 'immune privilege' in corneal neovascularization. The specific aims of the project are: 1) controlled induction and regression of murine corneal ..
  26. FAS L INDUCED APOPTOSIS IN CORNEA TRANSPLANTATION
    PATRICK STUART; Fiscal Year: 2004
    ..Consequently, we propose studies to better define the role that Fas and FasL play in corneal neovascularization.
  27. Hypoxia Induced Ocular Neovascularization Model
    WEN SENG; Fiscal Year: 2004
    ..Another cause of blindness is corneal neovascularization, which often results from injury and infection in the cornea...
  28. ENDOGENOUS STIMULATION OF CORNEAL NEOVASCULARIZATION
    Anthony Adamis; Fiscal Year: 2001
    ..VEGF expression increases 10-fold in inflamed cornea and is temporally and spatially correlated with corneal neovascularization. (2) Corneal epithelium and leukocytes express VEGF in inflamed cornea in vivo...
  29. In Vivo Ocular Angiogenesis Assay
    Maryann Haldi; Fiscal Year: 2005
    ..countries; retinopathy of prematurity, the major cause of vision loss in premature infants; and corneal neovascularization due to corneal injury, infection, or failed transplantation...
  30. EPITHELIAL AND ENDOTHELIAL PROLIFERATION IN CORN1 MICE
    Richard Smith; Fiscal Year: 2002
    The molecular basis of corneal neovascularization and corneal surface disease are still poorly understood...
  31. RNAi Therapeutics For Eye Neovascularization Diseases
    Qingquan Tang; Fiscal Year: 2004
    ..The latest studies have revealed that HSV infection stimulates the expression of VEGF, resulting in corneal neovascularization (NV)...
  32. Targeting Vasculogenesis and Interstitial Hypertension in Neurofibromatosis Type1
    Ugur Ozerdem; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  33. Thrombospondin-1 in prostate development and neoplasia
    Susan Crawford; Fiscal Year: 2004
    ..Results from these experiments should establish the function of TSP-1 in prostatic growth regulation and determine how TSP-1 may be useful as a prognostic indicator or as a treatment for prostatic diseases. ..
  34. Microbicidal peptides to prevent viral STD infection
    CURTIS BRANDT; Fiscal Year: 2004
    ..abstract_text> ..
  35. PECAM-1 and Alveolization
    Horace Delisser; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  36. Gene Gun Technology, Opioids, and Corneal Diseases
    IAN ZAGON; Fiscal Year: 2003
    ..Ultimately, such data can be employed to design molecular strategies to remedy visual dysfunction. ..
  37. PECAM-1'S INVOLVEMENT IN ANGIOGENESIS
    Horace Delisser; Fiscal Year: 2002
    ....
  38. Matrix and Morphogenesis Conference
    MARION GORDON; Fiscal Year: 2002
    ..This meeting provides a unique opportunity for senior and junior scientists to gather and discuss the latest and most advanced results in the field of extracellular matrix and morphogenesis. ..
  39. Angiogenic balance in a human tumor model of dormancy
    Taturo Udagawa; Fiscal Year: 2005
    ..An understanding of the interplay between angiogenic and antiangiogenic activities will yield insight into the biological basis for human tumor dormancy, and may also uncover new molecules for the treatment of cancer. ..
  40. CELL SIGNAL TRANSDUCTION IN CORNEAL WOUND HEALING
    Haydee Bazan; Fiscal Year: 2006
    ..This knowledge will allow us to characterize drugs that target selective steps of the signaling pathways. [unreadable] [unreadable]..
  41. VIRUS SPECIFIC FACTORS OF HSV TO CORNEAL DISEASE
    CURTIS BRANDT; Fiscal Year: 2008
    ..g. isoform A is involved with function B). These studies will add to our knowledge of the role of the US1 protein in ocular HSV infections and may lead to improved therapies. ..
  42. Expressions of Specialized Collagens in the Cornea
    Marion K Gordon; Fiscal Year: 2010
    ..The alterations in fibril architecture resulting from the dominant negative phenotype will be evaluated by transmission electron microscopy. ..
  43. Promoting Corneal Graft by Anti-Apoptotic Genes
    Reza Dana; Fiscal Year: 2006
    ..We believe that our goals are novel, innovative, and highly suited to the skills of our laboratory, and in delineating the role of apoptosis in corneal graft survival. ..
  44. The Molecular Basis of Pseudoexfoliation Syndrome
    Pratap Challa; Fiscal Year: 2007
    ..The Ophthalmology department at Duke University is an ideal setting for training physician-scientists and has an established track record of strong support for promising clinician-scientists. ..
  45. MOLECULAR BASIS OF OXIDATIVE MODIFICATION OF LDL
    ROBERT GERD SALOMON; Fiscal Year: 2010
    ..Our research is aimed at understanding why there is an accumulation of cholesterol in these cells because of their inability to efficiently break down the oxLDL and clear the released cholesterol. ..
  46. CORNEAL LIPID METABOLISM AND RESPONSE TO INFLAMMATION
    Haydee E P Bazan; Fiscal Year: 2010
    ..If our hypothesis and its corollaries are correct, then PAF antagonists can become effective therapeutic tools for maintaining the transparency and integrity of the cornea. ..
  47. Promoters for Glaucoma Gene Therapy
    CURTIS BRANDT; Fiscal Year: 2007
    ..abstract_text> ..
  48. EXPERIMENTAL PATHOGENESIS & THERAPY OF OCULAR ADENOVIRUS
    Y Gordon; Fiscal Year: 2006
    ..Furthermore, a better understanding of antiviral resistance and the innate immune host defenses will enable us to optimize our therapeutic options against this significant ocular pathogen. ..
  49. Assay for Inhibitors of Angiogenesis and Anthrax Toxin Receptor 1
    Michael Rogers; Fiscal Year: 2007
    ..They may also be useful in treating toxicity associated with anthrax infection. [unreadable]..