allergic conjunctivitis

Summary

Summary: Conjunctivitis due to hypersensitivity to various allergens.

Top Publications

  1. ncbi Allergic conjunctivitis: update on pathophysiology and prospects for future treatment
    Santa Jeremy Ono
    Department of Immunology, University College London, Institutes of Ophthalmology and Child Health and Moorfields Eye Hospital, NHS Trust, United Kingdom
    J Allergy Clin Immunol 115:118-22. 2005
  2. ncbi Contribution of IL-33 to induction and augmentation of experimental allergic conjunctivitis
    Saori Matsuba-Kitamura
    Department of Immunology and Medical Zoology, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan
    Int Immunol 22:479-89. 2010
  3. pmc Chemokines in the limbal form of vernal keratoconjunctivitis
    A M Abu El-Asrar
    Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia
    Br J Ophthalmol 84:1360-6. 2000
  4. ncbi Eotaxin-1 (CCL11) up-regulation in tears during seasonal allergic conjunctivitis
    Simone Eperon
    Ocular Immunology, Jules Gonin Eye Hospital, Av de France 15, 1000, Lausanne 7, Switzerland
    Graefes Arch Clin Exp Ophthalmol 242:966-70. 2004
  5. ncbi IL-10 confers protection from mast cell degranulation in a mouse model of allergic conjunctivitis
    Virgilio G Bundoc
    Exp Eye Res 85:575-9. 2007
  6. ncbi Blocking mast cell-mediated type I hypersensitivity in experimental allergic conjunctivitis by monocyte chemoattractant protein-1/CCR2
    Takeshi Tominaga
    Division of Ophthalmology and Visual Science, Tottori University Faculty of Medicine, Tottori, Japan
    Invest Ophthalmol Vis Sci 50:5181-8. 2009
  7. ncbi The economic and quality of life impact of seasonal allergic conjunctivitis in a Spanish setting
    Andrew F Smith
    Health Economics Unit, Alcon Laboratories U K Ltd, Hemel Hempstead, Herts, UK
    Ophthalmic Epidemiol 12:233-42. 2005
  8. ncbi Economic and quality-of-life impact of seasonal allergic conjunctivitis in Oxfordshire
    Andrew D Pitt
    Nuffield Laboratory of Ophthalmology, University of Oxford, Oxford, England, UK
    Ophthalmic Epidemiol 11:17-33. 2004
  9. ncbi Notch ligand Delta-like4 inhibits the development of murine experimental allergic conjunctivitis
    Atsuki Fukushima
    Department of Ophthalmology and Visual Science, Kochi Medical School, Nankoku, Japan
    Immunol Lett 121:140-7. 2008
  10. pmc Immune regulatory mechanisms in allergic conjunctivitis: insights from mouse models
    Jerry Y Niederkorn
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Curr Opin Allergy Clin Immunol 8:472-6. 2008

Detail Information

Publications233 found, 100 shown here

  1. ncbi Allergic conjunctivitis: update on pathophysiology and prospects for future treatment
    Santa Jeremy Ono
    Department of Immunology, University College London, Institutes of Ophthalmology and Child Health and Moorfields Eye Hospital, NHS Trust, United Kingdom
    J Allergy Clin Immunol 115:118-22. 2005
    b>Allergic conjunctivitis is in actuality a group of diseases affecting the ocular surface and is usually associated with type 1 hypersensitivity reactions...
  2. ncbi Contribution of IL-33 to induction and augmentation of experimental allergic conjunctivitis
    Saori Matsuba-Kitamura
    Department of Immunology and Medical Zoology, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan
    Int Immunol 22:479-89. 2010
    ..Thus, we tested the pathological role of IL-33 in allergic conjunctivitis (AC)...
  3. pmc Chemokines in the limbal form of vernal keratoconjunctivitis
    A M Abu El-Asrar
    Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia
    Br J Ophthalmol 84:1360-6. 2000
    ....
  4. ncbi Eotaxin-1 (CCL11) up-regulation in tears during seasonal allergic conjunctivitis
    Simone Eperon
    Ocular Immunology, Jules Gonin Eye Hospital, Av de France 15, 1000, Lausanne 7, Switzerland
    Graefes Arch Clin Exp Ophthalmol 242:966-70. 2004
    To compare in-season eotaxin-1 levels in tears of patients suffering from seasonal allergic conjunctivitis (SAC) with (1) tears of normal subjects and (2) tears of SAC patients out of season.
  5. ncbi IL-10 confers protection from mast cell degranulation in a mouse model of allergic conjunctivitis
    Virgilio G Bundoc
    Exp Eye Res 85:575-9. 2007
    ..This is the first in vivo rodent study which reports a novel role of IL-10 in stabilizing mast cells from degranulation by a secretagogue, by as of yet an unknown mechanism...
  6. ncbi Blocking mast cell-mediated type I hypersensitivity in experimental allergic conjunctivitis by monocyte chemoattractant protein-1/CCR2
    Takeshi Tominaga
    Division of Ophthalmology and Visual Science, Tottori University Faculty of Medicine, Tottori, Japan
    Invest Ophthalmol Vis Sci 50:5181-8. 2009
    ..To characterize the roles played by monocyte chemoattractant protein-1 and its preferential receptor CCR2 (MCP-1/CCL2) in acute allergic inflammation...
  7. ncbi The economic and quality of life impact of seasonal allergic conjunctivitis in a Spanish setting
    Andrew F Smith
    Health Economics Unit, Alcon Laboratories U K Ltd, Hemel Hempstead, Herts, UK
    Ophthalmic Epidemiol 12:233-42. 2005
    Seasonal allergic conjunctivitis (SAC) is a highly prevalent condition that exacts a range of costs from its sufferers...
  8. ncbi Economic and quality-of-life impact of seasonal allergic conjunctivitis in Oxfordshire
    Andrew D Pitt
    Nuffield Laboratory of Ophthalmology, University of Oxford, Oxford, England, UK
    Ophthalmic Epidemiol 11:17-33. 2004
    The purpose of this study was to examine the economic and quality-of-life (QoL) impact of seasonal allergic conjunctivitis (SAC) from the individual patient perspective.
  9. ncbi Notch ligand Delta-like4 inhibits the development of murine experimental allergic conjunctivitis
    Atsuki Fukushima
    Department of Ophthalmology and Visual Science, Kochi Medical School, Nankoku, Japan
    Immunol Lett 121:140-7. 2008
    To investigate the involvement of Notch ligands in the development of experimental allergic conjunctivitis (EC) in mice.
  10. pmc Immune regulatory mechanisms in allergic conjunctivitis: insights from mouse models
    Jerry Y Niederkorn
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Curr Opin Allergy Clin Immunol 8:472-6. 2008
    This review highlights recent findings regarding the immune regulation of allergic conjunctivitis. Mouse models have facilitated prospective studies that have not been possible in patients...
  11. ncbi Roles of galectin-9 in the development of experimental allergic conjunctivitis in mice
    Atsuki Fukushima
    Department of Ophthalmology and Visual Science, Kochi Medical School, Nankoku, Japan fukushima kochi u ac jp
    Int Arch Allergy Immunol 146:36-43. 2008
    ..Here, we investigated whether administration of anti-galectin-9 antibodies (Abs) affects the development of murine experimental allergic conjunctivitis (EC), a Th2-mediated disease.
  12. ncbi Seasonal and perennial allergic conjunctivitis
    Alex H C Wong
    Asian Medical Center, an affiliate with The University of Calgary Medical Clinic, Calgary, Alberta, Canada
    Recent Pat Inflamm Allergy Drug Discov 3:118-27. 2009
    Seasonal and perennial allergic conjunctivitis are IgE-mediated, hypersensitivity ophthalmic conditions characterized by ocular pruritus, epiphora, and hyperemia...
  13. ncbi Time to onset and duration of action of the antihistamine bepotastine besilate ophthalmic solutions 1.0% and 1.5% in allergic conjunctivitis: a phase III, single-center, prospective, randomized, double-masked, placebo-controlled, conjunctival allergen cha
    Mark B Abelson
    Ora, Inc, Andover, Massachusetts 01810, USA
    Clin Ther 31:1908-21. 2009
    ..Based on a history of clinical effectiveness and tolerability of oral bepotastine besilate in the treatment of allergic symptoms, bepotastine besilate is being tested as a potential ophthalmic medication for allergic conjunctivitis.
  14. ncbi Global map of the prevalence of symptoms of rhinoconjunctivitis in children: The International Study of Asthma and Allergies in Childhood (ISAAC) Phase Three
    N Ait-Khaled
    International Union Against Tuberculosis and Lung Disease, Paris, France
    Allergy 64:123-48. 2009
    ..Phase One of the International Study of Asthma and Allergies in Childhood (ISAAC) measured the global patterns of prevalence and severity of symptoms of rhinoconjunctivitis in children in 1993-1997...
  15. ncbi Efficacy and tolerability of ophthalmic epinastine assessed using the conjunctival antigen challenge model in patients with a history of allergic conjunctivitis
    Mark B Abelson
    Ophthalmic Research Associates, North Andover, USA
    Clin Ther 26:35-47. 2004
    ..Epinastine hydrochloride is a nonsedating antihistamine with a high affinity for histamine H(1) receptors, together with mast cell-stabilizing and anti-inflammatory activities...
  16. ncbi Optimal dose, efficacy, and safety of once-daily sublingual immunotherapy with a 5-grass pollen tablet for seasonal allergic rhinitis
    Alain Didier
    Department of Pneumology, Larrey Hospital, Toulouse, France
    J Allergy Clin Immunol 120:1338-45. 2007
    ..Sublingual immunotherapy is well tolerated and data suggest its effectiveness for the treatment of allergic rhinitis in adults, but it lacks optimum dose definition...
  17. ncbi Active matrix metalloproteinases in the tear fluid of individuals with vernal keratoconjunctivitis
    Naoki Kumagai
    Department of Biomolecular Recognition and Ophthalmology, Yamaguchi University School of Medicine, Ube City, Japan
    J Allergy Clin Immunol 110:489-91. 2002
    ..Tear fluid was collected from 6 eyes of 6 patients with active VKC, 14 eyes of 14 patients with active allergic conjunctivitis, and 6 eyes of 6 nonallergic healthy volunteers...
  18. ncbi Roles of chemokines in ocular allergy and possible therapeutic strategies
    Dai Miyazaki
    Division of Ophthalmology and Visual Science, Faculty of Medicine, Tottori University, 36 1 Nishimachi, Yonago 683 8504, Japan
    Cornea 23:S48-54. 2004
    ..We emphasize the functions as modulator of mast cell activation/differentiation. With the prospect of understanding these functions, new modalities of drugs specifically developed to target CCL11/CCR3 interaction have been discussed...
  19. ncbi Efficacy of levocabastine hydrochloride ophthalmic suspension in the conjunctival allergen challenge test in Japanese subjects with seasonal allergic conjunctivitis
    Etsuko Takamura
    Department of Ophthalmology, Tokyo Women s Medical University School of Medicine, Tokyo, Japan
    Allergol Int 55:157-65. 2006
    ..025% levocabastine hydrochloride in Japanese subjects with seasonal allergic conjunctivitis and its duration of action using the conjunctival allergen challenge (CAC) test.
  20. ncbi Modulation of murine experimental allergic conjunctivitis by treatment with alpha-galactosylceramide
    Atsuki Fukushima
    Department of Ophthalmology and Visual Science, Kochi Medical School, Kohasu, Nankoku city 783 8505, Japan
    Immunol Lett 107:32-40. 2006
    ..Here, we investigated whether alpha-GalCer treatment can also modulate the development of experimental allergic conjunctivitis (EC)...
  21. ncbi Apafant, a potent platelet-activating factor antagonist, blocks eosinophil activation and is effective in the chronic phase of experimental allergic conjunctivitis in guinea pigs
    Masatomo Kato
    Research and Development Center, Santen Pharmaceutical Co, Ltd, Nara 630 0101, Japan
    J Pharmacol Sci 95:435-42. 2004
    ..to confirm the efficacy of Apafant (a potent PAF antagonist) ophthalmic solution in chronic experimental allergic conjunctivitis. Guinea pigs were actively immunized and allergic conjunctivitis was induced by repetitive instillation ..
  22. ncbi Endogenous IL-17 does not play a significant role in the development of experimental murine allergic conjunctivitis
    Atsuki Fukushima
    Department of Ophthalmology, Kochi Medical School, Nankoku, Japan
    Int Arch Allergy Immunol 147:206-12. 2008
    ..Here, we aimed to investigate the role IL-17 plays in the development of murine experimental allergic conjunctivitis (EC) which is also a Th2-mediated disease.
  23. ncbi Clinical evaluation of total IgE in tears of patients with allergic conjunctivitis disease using a novel application of the immunochromatography method
    Noriko Inada
    Department of Ophthalmology, Division of Visual Sciences, Nihon University School of Medicine, Tokyo, Japan
    Allergol Int 58:585-9. 2009
    The determination of total IgE in tears is useful as a diagnostic tool in allergic conjunctivitis disease (ACD)...
  24. ncbi Transcriptional analyses before and after suppression of immediate hypersensitivity reactions by CCR3 blockade in eyes with experimental allergic conjunctivitis
    Naoki Komatsu
    Division of Ophthalmology and Visual Science, Faculty of Medicine, Tottori University, Totttori, Japan
    Invest Ophthalmol Vis Sci 49:5307-13. 2008
    To characterize the transcriptome of allergic conjunctivitis mediated by eosinophil-related chemokine receptor CCR3 and to identify a candidate for possible therapeutic intervention in eosinophilic inflammation of the eye.
  25. ncbi Evaluation of novel scoring system named 5-5-5 exacerbation grading scale for allergic conjunctivitis disease
    Jun Shoji
    Department of Ophthalmology, Division of Visual Sciences, Nihon University School of Medicine, Tokyo, Japan
    Allergol Int 58:591-7. 2009
    The objective of this study is to evaluate the practical usefulness of a scoring system using the 5-5-5 exacerbation grading scale for allergic conjunctivitis disease (ACD).
  26. ncbi Effects of multiple dexamethasone treatments on aggravation of allergic conjunctivitis associated with mast cell hyperplasia
    Takuya Nagata
    Department of Pharmacology, Kyoto Pharmaceutical University, Yamashina ku, Kyoto 607 8414, Japan
    Biol Pharm Bull 31:464-8. 2008
    In a Japanese cedar pollen-induced allergic conjunctivitis model in guinea pigs, symptoms were aggravated by repeated pollen challenges. In addition, the number of mast cells in the conjunctiva was increased by multiple challenges...
  27. pmc Demographic study of paediatric allergic conjunctivitis within a multiethnic patient population
    A J Singh
    Br J Ophthalmol 87:1195-6. 2003
  28. ncbi Allergic conjunctivitis and H1 antihistamines
    A Del Cuvillo
    Clínica Dr Lobatón, Cadiz, Spain
    J Investig Allergol Clin Immunol 19:11-8. 2009
    b>Allergic conjunctivitis is the most common form of ophthalmological allergy...
  29. ncbi Ambient particulate pollution and the world-wide prevalence of asthma, rhinoconjunctivitis and eczema in children: Phase One of the International Study of Asthma and Allergies in Childhood (ISAAC)
    H Ross Anderson
    Division of Community Health Sciences, MRC HPA Centre for Environment and Health, St George s, University of London, Cranmer Terrace, London SW17 0RE, UK
    Occup Environ Med 67:293-300. 2010
    ..To investigate the effect of ambient particulate matter on variation in childhood prevalence of asthma, rhinoconjunctivitis and eczema...
  30. ncbi Tear eotaxin levels in giant papillary conjunctivitis associated with ocular prosthesis
    Ozge Sarac
    Department of Ophthalmology, Hacettepe University School of Medicine, Ankara, Turkey
    Ocul Immunol Inflamm 11:223-30. 2003
    ..To examine the role of eotaxin and eosinophil recruitment in the immunopathogenesis of ocular prosthesis-associated giant papillary conjunctivitis (GPC)...
  31. ncbi A novel murine model of allergic conjunctivitis
    M T Magone
    National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1858, USA
    Clin Immunol Immunopathol 87:75-84. 1998
    b>Allergic conjunctivitis affects over 40 million patients per year in the United States...
  32. ncbi Meibomian gland duct distortion in patients with perennial allergic conjunctivitis
    Reiko Arita
    Itoh Clinic, Saitama, Japan
    Cornea 29:858-60. 2010
    To observe morphologic changes of meibomian glands in patients with and without perennial allergic conjunctivitis (AC) and to assess the relation between morphologic changes of the meibomian glands of both eyelids and tear film parameters.
  33. ncbi Allergic conjunctivitis and the impact of allergic rhinitis
    Leonard Bielory
    STARx Allergy and Center and Clinical Research Center, Rutgers University, 400 Mountain Avenue, Springfield, NJ, 07081, USA
    Curr Allergy Asthma Rep 10:122-34. 2010
    ..In the past year, knowledge of the relationships between allergic conjunctivitis and allergic rhinitis has increased...
  34. ncbi B7-H3 regulates the development of experimental allergic conjunctivitis in mice
    Atsuki Fukushima
    Department of Ophthalmology and Visual Science, Kochi Medical School, Kohasu, Oko cho, Nankoku city 783 8505, Japan
    Immunol Lett 113:52-7. 2007
    ..Here, we aimed to investigate whether B7-H3 is involved in the development of murine experimental allergic conjunctivitis (EC), which is predominantly mediated by Th2 cells...
  35. pmc A randomized, placebo-controlled clinical trial of tacrolimus ophthalmic suspension 0.1% in severe allergic conjunctivitis
    Yuichi Ohashi
    Department of Ophthalmology, University of Ehime School of Medicine, Shizukawa, Toon City Ehime, 7910295, Japan
    J Ocul Pharmacol Ther 26:165-74. 2010
    To examine the efficacy of tacrolimus ophthalmic suspension 0.1% in treating severe allergic conjunctivitis.
  36. pmc Conjunctival macrophages act as antigen-presenting cells in the conjunctiva during the development of experimental allergic conjunctivitis
    Waka Ishida
    Department of Ophthalmology, Kochi Medical School, Nankoku City, Japan
    Mol Vis 16:1280-5. 2010
    Antigen (Ag)-presenting cells (APCs) participate in the development of allergic conjunctivitis (AC). However, the conjunctival APCs that take up Ag in AC have not been identified...
  37. ncbi Allergic conjunctivitis: a national cross-sectional study of clinical characteristics and quality of life
    Jorge Palmares
    Ophthalmology Department, Hospital S Joao, Porto, Portugal
    Eur J Ophthalmol 20:257-64. 2010
    ..To characterize clinical and demographic aspects of allergic conjunctivitis in Portugal, using a structured questionnaire...
  38. ncbi Allergic conjunctivitis as a risk factor for laser in situ keratomileusis
    N Asano-Kato
    Minamiaoyama Eye Clinic, Tokyo, Japan
    J Cataract Refract Surg 27:1469-72. 2001
    To analyze the effect of allergic conjunctivitis (AC) on the outcome of laser in situ keratomileusis (LASIK) in myopic eyes.
  39. ncbi Allergic conjunctivitis as a risk factor for regression and haze after photorefractive keratectomy
    H Y Yang
    Department of Ophthalmology, Tokyo Dental College, Chiba, Japan
    Am J Ophthalmol 125:54-8. 1998
    To analyze the relation between allergic conjunctivitis and the results of photorefractive keratectomy performed with an excimer laser in myopic eyes.
  40. ncbi Role of interferon-gamma in a mouse model of allergic conjunctivitis
    Michael E Stern
    Allergan, Irvine, CA, USA
    Invest Ophthalmol Vis Sci 46:3239-46. 2005
    To characterize the effect of repeated topical exposure to allergen in a mouse model of allergic conjunctivitis and to determine the role of interferon-gamma (IFN-gamma) in the pathogenesis of allergic conjunctivitis.
  41. pmc Randomised controlled trial of topical ciclosporin A in steroid dependent allergic conjunctivitis
    M Daniell
    Centre for Eye Research Australia, University of Melbourne, Corneal Clinic, Royal Victorian Eye and Ear Hospital, Locked Bag 8, East Melbourne 8002, Australia
    Br J Ophthalmol 90:461-4. 2006
    To evaluate the efficacy, safety, and therapeutic effect of topical ciclosporin A 0.05% as a steroid sparing agent in steroid dependent allergic conjunctivitis.
  42. ncbi [Epidemiological and clinical features of allergic conjunctivitis in a reference center]
    Patricia Maria Fernandes Marback
    Departamento de Oftalmologia, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brasil
    Arq Bras Oftalmol 70:312-6. 2007
    To evaluate demographic and clinical features of patients with allergic conjunctivitis in a reference center.
  43. ncbi [Allergic conjunctivitis: diagnosis and treatment]
    F Marmouz
    Allergologue, 1, rue Thiers, 95300 Pontoise
    Eur Ann Allergy Clin Immunol 36:25-9. 2004
    b>Allergic conjunctivitis are the most frequent presentation of ocular allergy...
  44. ncbi The dendritic cell in allergic conjunctivitis
    Bita Manzouri
    Institute of Ophthalmology, Moorfields Eye Hospital, London, UK
    Ocul Surf 6:70-8. 2008
    ..We review what has been learned from studies of both human ocular allergy and murine models and comment on how this compares to allergic reactions in other mucosal tissues...
  45. ncbi Effects of Vasocon-A in the allergen challenge model of acute allergic conjunctivitis
    M B Abelson
    Department of Ophthalmology, Harvard Medical School, Boston, MA
    Arch Ophthalmol 108:520-4. 1990
    ..Three independent study sites were used. The allergen challenge model of acute allergic conjunctivitis was selected to assess the agent as it provided a standardized and precise way to measure drug ..
  46. ncbi Roles of OX40 in the development of murine experimental allergic conjunctivitis: exacerbation and attenuation by stimulation and blocking of OX40
    Atsuki Fukushima
    Department of Ophthalmology, Kochi Medical School, Nankoku City, Japan
    Invest Ophthalmol Vis Sci 47:657-63. 2006
    To investigate the roles of interaction between OX40 and OX40 ligand (OX40L) in the development of experimental allergic conjunctivitis (EC) in mice.
  47. ncbi Allergic conjunctivitis and nasal allergy
    Zdenek Pelikan
    Allergy Research Foundation, Breda, The Netherlands
    Curr Allergy Asthma Rep 10:295-302. 2010
    b>Allergic conjunctivitis (AC) can be divided into the primary form (caused by an allergic reaction occurring primarily in the conjunctivae) and the secondary form (induced by allergic reaction originating primarily in the nasal mucosa, ..
  48. ncbi Bilateral conjunctival mucosa-associated lymphoid tissue lymphoma misdiagnosed as allergic conjunctivitis
    D H Lee
    Department of Ophthalmology and Anatomic Pathology, Ilsan Paik Hospital, Ilsan, Korea
    Cornea 20:427-9. 2001
    This report aimed to discuss two nearly identical cases of primary conjunctival mucosa-associated lymphoid tissue (MALT) lymphoma mimicking allergic conjunctivitis.
  49. ncbi Increasing effect by simultaneous use of levocabastine and pemirolast on experimental allergic conjunctivitis in rats
    Kazuhisa Minami
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Okayama, Japan
    Biol Pharm Bull 28:473-6. 2005
    ..1% pemirolast potassium ophthalmic solution (pemirolast) on experimental allergic conjunctivitis in rats was investigated...
  50. ncbi Anterior uveitis and concurrent allergic conjunctivitis associated with long-term use of topical 0.2% brimonidine tartrate
    Heidi I Becker
    Department of Surgery Ophthalmology, Dartmouth Medical School, Hannover, NH 03755 3842, USA
    Arch Ophthalmol 122:1063-6. 2004
  51. ncbi Effects of nonsteroidal anti-inflammatory drugs on experimental allergic conjunctivitis in Guinea pigs
    Terumasa Hashimoto
    Medical Research and Development Department, Sagami Research Laboratories, Wakamoto Pharmaceutical Co, Ltd Tokyo, Japan
    J Ocul Pharmacol Ther 19:569-77. 2003
    The effects of nonsteroidal anti-inflammatory drugs (NSAIDs) on experimental allergic conjunctivitis, induced by ocular challenge with antigen in actively sensitized guinea pigs, were investigated...
  52. ncbi Allergic conjunctivitis in children with asthma, rhinitis and eczema in a secondary outpatient clinic
    Josefine Gradman
    Children s Clinic Randers, Randers, Denmark
    Pediatr Allergy Immunol 17:524-6. 2006
    Little evidence is available on the prevalence of allergic conjunctivitis in pediatric populations...
  53. ncbi Allergic conjunctivitis and latent infections
    Raimondo Forte
    Eye Department, University Federico II, Naples, Italy
    Cornea 28:839-42. 2009
    The purpose of this study was to evaluate in a large series the incidence of latent infection during chronic allergic conjunctivitis.
  54. ncbi Prostaglandin D2 induces chemotaxis in eosinophils via its receptor CRTH2 and eosinophils may cause severe ocular inflammation in patients with allergic conjunctivitis
    Hiroshi Fujishima
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Cornea 24:S66-S70. 2005
    Eosinophils are known to have important roles in the pathogenesis of allergic conjunctivitis. Prostaglandin (PG) D2, which has been implicated as a factor in allergic diseases, is known to have chemotactic activity for eosinophils...
  55. ncbi Seasonal and perennial allergic conjunctivitis: the possible role of nasal allergy
    Zdenek Pelikan
    Allergy Research Foundation, Breda, The Netherlands
    Clin Experiment Ophthalmol 37:448-57. 2009
    ..This work aims to investigate the possible role of nasal allergy in seasonal (SAC) and perennial (PAC) allergic conjunctivitis and the value of nasal challenges with allergens (nasal provocation tests [NPTs]) for the diagnostic ..
  56. ncbi Cyclosporin A eye drops inhibit fibrosis and inflammatory cell infiltration in murine type I allergic conjunctivitis without affecting the early-phase reaction
    Daisuke Shii
    Research and Development Center, Santen Pharmaceutical Co, Ltd, 8916 16 Takayama cho, Ikoma shi, Nara 630 0101, Japan
    Curr Eye Res 34:426-37. 2009
    ..cyclosporin A eye drops in severe allergic diseases such as vernal keratoconjunctivitis, the inhibitory effects of cyclosporin A eye drops on fibrosis and inflammatory cell infiltration in murine allergic conjunctivitis were evaluated.
  57. ncbi [Allergic conjunctivitis in children]
    Benjamin Zepeda Ortega
    Hospital Infantil de Mexico Federico Gomez
    Rev Alerg Mex 54:41-53. 2007
    b>Allergic conjunctivitis is a group of diseases that are frequent in childhood, associated to several allergic diseases affecting the ocular surface. It is related to type 1 hypersensitivity reactions...
  58. ncbi Differential contributions of B7-1 and B7-2 to the development of murine experimental allergic conjunctivitis
    Tamaki Sumi
    Department of Ophthalmology, Kochi Medical School, Kohasu, Oko cho, Nankoku city 783 8505, Japan
    Immunol Lett 108:62-7. 2007
    ..We investigated whether B7-1 and B7-2 play a role in the development of T cell-mediated experimental allergic conjunctivitis (EC)...
  59. pmc Allergic conjunctivitis exacerbates corneal allograft rejection by activating Th1 and th2 alloimmune responses
    Jerry Y Niederkorn
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9057, USA
    J Immunol 184:6076-83. 2010
    b>Allergic conjunctivitis (AC) and airway hyperreactivity exacerbate corneal allograft rejection...
  60. ncbi Relationship between refraction and allergic conjunctivitis
    T Mimura
    Department of Ophthalmology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Eye (Lond) 23:63-6. 2009
    ..We investigated the relationship between refractive error and allergic conjunctivitis in order to reveal possible insights into the pathogenesis in 1015 subjects.
  61. ncbi Effects of ketotifen 0.025% and lodoxamide 0.1% on eosinophil infiltration into the guinea pig conjunctiva in a model of allergic conjunctivitis
    Christian Schoch
    Novartis Ophthalmics AG, Basel, Switzerland
    J Ocul Pharmacol Ther 19:153-9. 2003
    The effects of ketotifen and lodoxamide on eosinophil infiltration were assessed in a guinea pig model of allergic conjunctivitis. The two active treatments were coded in this masked study in which 30 male guinea pigs, sensitized to ..
  62. ncbi Topical tacrolimus 0.03% ointment for intractable allergic conjunctivitis: an open-label pilot study
    Liat Attas-Fox
    Department of Ophthalmology, Assaf Harofeh Medical Center, Zerifin, Israel
    Curr Eye Res 33:545-9. 2008
    To evaluate the feasibility of tacrolimus 0.03% dermatological ointment (Protopic) in the treatment of intractable allergic conjunctivitis.
  63. ncbi Role of histamine H(4) receptor in allergic conjunctivitis in mice
    Yoshiyuki Nakano
    Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Eur J Pharmacol 608:71-5. 2009
    We investigated the character of histamine H(1) receptor and H(4) receptor in allergic conjunctivitis. Histamine is the most important mediator in allergic conjunctivitis...
  64. ncbi Analysis of the interaction between IFN-gamma and IFN-gammaR in the effector phase of experimental murine allergic conjunctivitis
    Atsuki Fukushima
    Department of Ophthalmology and Visual Science, Kochi Medical School, Japan
    Immunol Lett 107:119-24. 2006
    IFN-gamma acts to promote the severity of experimental allergic conjunctivitis (EC) during the effector phase...
  65. ncbi Staphylococcus aureus accelerates an experimental allergic conjunctivitis by Toll-like receptor 2-dependent manner
    So Hyang Chung
    Department of Ophthalmology and Visual Science, Kangnam St Mary s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
    Clin Immunol 131:170-7. 2009
    b>Allergic conjunctivitis is an inflammatory eye disease mediated by Th2-type cytokines and Staphylococcus aureus (S. aureus) colonization has been suggested as playing a role...
  66. ncbi Regulatory T cells participate in 4-1BB-mediated suppression of experimental allergic conjunctivitis
    Tamaki Sumi
    Department of Ophthalmology, Kochi Medical School, Kohasu Oko cho, Nankoku City, Japan
    Int Arch Allergy Immunol 148:305-10. 2009
    ..that treatment with an agonistic anti-4-1BB Ab during the induction phase of murine experimental allergic conjunctivitis (EC) suppresses the development of this model disease...
  67. pmc Ablation of type I hypersensitivity in experimental allergic conjunctivitis by eotaxin-1/CCR3 blockade
    Dai Miyazaki
    Division of Ophthalmology and Visual Science, Tottori University Faculty of Medicine, Tottori, Japan
    Int Immunol 21:187-201. 2009
    ..by chemokine receptor 3 (CCR3), an eotaxin-1 receptor, effects of CCR3 blockade were tested with an allergic conjunctivitis model and in ex vivo isolated connective tissue-type mast cells...
  68. ncbi Efficacy and safety of ketotifen fumarate 0.025% in the conjunctival antigen challenge model of ocular allergic conjunctivitis
    Jack V Greiner
    Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts, USA
    Am J Ophthalmol 136:1097-105. 2003
    ..To determine the duration of action of ketotifen 0.025% eye drops vs placebo taken as single or multiple doses in an allergen challenge model...
  69. ncbi Long-term safety of loteprednol etabonate 0.2% in the treatment of seasonal and perennial allergic conjunctivitis
    Haroon Ilyas
    Department of Ophthalmology, University of South Florida College of Medicine, Tampa, FL 33613, USA
    Eye Contact Lens 30:10-3. 2004
    To determine the long-term safety of the topical steroid, loteprednol etabonate 0.2%, in the treatment of seasonal and perennial allergic conjunctivitis.
  70. ncbi Allergic conjunctivitis
    Leonard Bielory
    Division of Allergy, Immunology, and Rheumatology, UMDNJ New Jersey Medical School, 90 Bergen Street, DOC Suite 4700, Newark, NJ 07103, USA
    Immunol Allergy Clin North Am 28:43-58, vi. 2008
    b>Allergic conjunctivitis is common, especially during the allergy season. Consultation with the allergist to perform skin tests or in vitro tests may be useful and confirmatory in the diagnosis of ocular allergy...
  71. pmc Novel transglutaminase inhibitors reverse the inflammation of allergic conjunctivitis
    Joonhong Sohn
    Department of Ophthalmology, Asan Medical Center, Seoul, Republic of Korea
    J Clin Invest 111:121-8. 2003
    ..peptides, which had dual inhibitory effects on purified TGase 2 and PLA(2), reversed the inflammation of allergic conjunctivitis to ragweed in a guinea pig model...
  72. ncbi Ocular comfort and drying effects of three topical antihistamine/mast cell stabilizers in adults with allergic conjunctivitis: a randomized, double-masked crossover study
    Gail L Torkildsen
    Andover Eye Associates, Andover, Massachusetts 01845, USA
    Clin Ther 30:1264-71. 2008
    The aim of this study was to compare short-term (5-minute) ocular comfort and drying effects of 3 topical antihistamine/mast cell stabilizers-epinastine, azelastine, and ketotifen-in patients with allergic conjunctivitis (AC).
  73. pmc Topical treatments for seasonal allergic conjunctivitis: systematic review and meta-analysis of efficacy and effectiveness
    Christopher G Owen
    Department of Community Health Sciences, St George s Hospital Medical School, London
    Br J Gen Pract 54:451-6. 2004
    ..Evidence for the effectiveness of topical treatments, in providing symptomatic relief from ocular allergy, remains uncertain...
  74. ncbi Multicenter clinical evaluation of bepotastine besilate ophthalmic solutions 1.0% and 1.5% to treat allergic conjunctivitis
    Thomas T Macejko
    Eye Care Associates of Greater Cincinnati, Inc, Fairfield, Ohio, USA
    Am J Ophthalmol 150:122-127.e5. 2010
    ..0% and 1.5% compared with placebo at reducing ocular itching and conjunctival hyperemia in the conjunctival allergen challenge (CAC) model of allergic conjunctivitis.
  75. ncbi Preliminary evidence of the efficacy of probiotic eye-drop treatment in patients with vernal keratoconjunctivitis
    Alfonso Iovieno
    Interdisciplinary Center for Biomedical Research CIR, Laboratory of Ophthalmology, University of Rome Campus Bio Medico, Via E Longoni, 83, 00155, Rome, Italy
    Graefes Arch Clin Exp Ophthalmol 246:435-41. 2008
    ..Probiotics have been shown to improve allergic inflammation. The aim of this study was to evaluate the efficacy of Lactobacillus Acidophilus eye-drops in controlling signs and symptoms of vernal keratoconjunctivitis (VKC)...
  76. ncbi Efficacy and safety of sublingual immunotherapy with grass allergen tablets for seasonal allergic rhinoconjunctivitis
    Ronald Dahl
    Department of Respiratory Diseases, Aarhus University Hospital, Aarhus, Denmark
    J Allergy Clin Immunol 118:434-40. 2006
    ..The sublingual route also has potential, although definitive evidence from large randomized controlled trials has been lacking...
  77. ncbi Engagement of 4-1BB inhibits the development of experimental allergic conjunctivitis in mice
    Atsuki Fukushima
    Department of Ophthalmology, Kochi Medical School, Nankoku City, Japan
    J Immunol 175:4897-903. 2005
    ..We investigated the effect of anti-4-1BB Abs on the development and progression of experimental allergic conjunctivitis in mice...
  78. ncbi Update on ocular allergy treatment
    Leonard Bielory
    UMDNJ Asthma and Allergy Research Center, Department of Medicine, Pediatrics and Ophthalmology, New Jersey Medical School, Newark, New Jersey 07103, USA
    Expert Opin Pharmacother 3:541-53. 2002
    ..The associated healthcare costs related to allergic conjunctivitis has been commonly nestled with allergic rhinitis and has been reported to be as high as US$5...
  79. ncbi Efficacy of olopatadine HCI 0.1%, ketotifen fumarate 0.025%, epinastine HCI 0.05%, emedastine 0.05% and fluorometholone acetate 0.1% ophthalmic solutions for seasonal allergic conjunctivitis: a placebo-controlled environmental trial
    Mehmet Borazan
    Department of Ophthalmology, Baskent University School of Medicine, Ankara, Turkey
    Acta Ophthalmol 87:549-54. 2009
    ..clinical efficacy and ocular surface variables of olopatadine, ketotifen fumarate, epinastine, emedastine and fluorometholone acetate ophthalmic solutions in preventing the signs and symptoms of seasonal allergic conjunctivitis (SAC).
  80. pmc Efficacy and safety of ketotifen eye drops in the treatment of seasonal allergic conjunctivitis
    M Kidd
    Department of General Practice, The University of Sydney, Sydney, NSW, Australia
    Br J Ophthalmol 87:1206-11. 2003
    ..These multiple, pharmacological mechanisms provided the rationale for assessing the efficacy and safety of ketotifen 0.025% eye drops in subjects with seasonal allergic conjunctivitis (SAC) in an environmental setting.
  81. ncbi Nonseasonal allergic conjunctivitis in the tropics: experience in a tertiary care institution
    Harold Choi
    Department of Ophthalmology, National University Hospital, Singapore
    Ocul Immunol Inflamm 16:141-5. 2008
    ..types of pathology, clinical features, precipitating factors, and treatment outcomes of patients with allergic conjunctivitis in a tropical climate receiving corneal subspecialist intervention...
  82. ncbi Bepotastine besilate, a highly selective histamine H(1) receptor antagonist, suppresses vascular hyperpermeability and eosinophil recruitment in in vitro and in vivo experimental allergic conjunctivitis models
    Tetsuo Kida
    Research Laboratories, Senju Pharmaceutical Co, Ltd, 1 5 4, Murotani, Nishi ku, Kobe, Hyogo 651 2241, Japan
    Exp Eye Res 91:85-91. 2010
    ..H(1) receptor antagonist, when compared with other histamine H(1) receptor antagonists, using guinea pig allergic conjunctivitis models and in vitro models of eosinophil recruitment and mast cell membrane stabilization...
  83. ncbi Management of severe allergic conjunctivitis with topical cyclosporin a 0.05% eyedrops
    Altan A Ozcan
    Department of Ophthalmology, Cukurova University, Faculty of Medicine, Adana, Turkey
    Cornea 26:1035-8. 2007
    To evaluate the efficacy of topical cyclosporin A 0.05% in the management of severe allergic conjunctivitis.
  84. pmc The effect of ketotifen on inflammatory markers in allergic conjunctivitis: an open, uncontrolled study
    Andrea P Martin
    Dpto Bioquímica Clínica, Facultad Ciencias Quimicas, Universidad Nacional de Cordoba, Argentina
    BMC Ophthalmol 3:2. 2003
    The efficacy and safety of ketotifen eye drop treatment in allergic conjunctivitis (AC) management is perfectly known by several studies, but the mechanism of action at the biochemical levels is poorly understood so we decided to perform ..
  85. ncbi Prostaglandin E receptor subtype EP3 in conjunctival epithelium regulates late-phase reaction of experimental allergic conjunctivitis
    Mayumi Ueta
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    J Allergy Clin Immunol 123:466-71. 2009
    ..We previously demonstrated that the prostaglandin E(2) (PGE(2))-EP3 pathway negatively regulates allergic reactions in a murine allergic asthma model...
  86. ncbi The role of neuromediators in ocular allergy
    Alessandra Micera
    CIR Laboratory of Ophthalmology, Bietti Eye Foundation, University Campus Bio Medico, Italy
    Curr Opin Allergy Clin Immunol 8:466-71. 2008
    ....
  87. ncbi Prevalence of allergic conjunctivitis in school children of Karachi
    Rashid Baig
    Section of Ophthalmology, Department of Surgery, Aga Khan University, Karachi, Pakistan
    J Pak Med Assoc 60:371-3. 2010
    To determine the prevalence of allergic conjunctivitis in children in selected schools in Karachi, Pakistan.
  88. ncbi DNA-based immunotherapeutics for the treatment of allergic disease
    A A Horner
    Department of Medicine and The Sam and Rose Stein Institute for Research on Aging, University of California, San Diego, La Jolla 92093-0663, USA
    Immunol Rev 179:102-18. 2001
    ..This review will focus on our present understanding of the biological activities of DNA-based immunotherapeutics and their application to the treatment of allergic diseases...
  89. ncbi Dynamic changes in conjunctival dendritic cell numbers, anatomical position and phenotype during experimental allergic conjunctivitis
    Masaharu Ohbayashi
    Department of Ophthalmology and Medicine, Emory University School of Medicine and Emory Eye Center, Atlanta, GA 30322, USA
    Exp Mol Pathol 83:216-23. 2007
    ..aims of this study are to characterize the phenotypes and numbers of DCs present in the murine model of allergic conjunctivitis using the technique of immunohistochemistry so as to aid the understanding of the mechanisms involved in ..
  90. pmc Nerve growth factor has a modulatory role on human primary fibroblast cultures derived from vernal keratoconjunctivitis-affected conjunctiva
    Alessandra Micera
    CIR Laboratory of Ophthalmology, University Campus Bio Medico, Rome, Italy
    Mol Vis 13:981-7. 2007
    ..NGF, a pleiotrophic factor with documented profibrogenic activities, is produced by inflammatory and structural cells populating the VKC conjunctiva and is increased in the serum and tears of VKC patients...
  91. ncbi Comparison of 0.1% bromfenac sodium and 0.1% pemirolast potassium for the treatment of allergic conjunctivitis
    Minori Miyake-Kashima
    Department of Ophthalmology, Tokyo Dental College, Chiba, Ichikawa, Japan
    Jpn J Ophthalmol 48:587-90. 2004
    ..1% bromfenac sodium (Bromfenac), with that of an antiallergic agent, 0.1% pemirolast potassium (Pemirolast), in the treatment of seasonal allergic conjunctivitis in Japanese patients.
  92. ncbi Immunopathogenesis of vernal keratoconjunctivitis
    A M Abu el Asrar
    Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia
    Bull Soc Belge Ophtalmol 261:15-24. 1996
    ....
  93. ncbi Azelastine eye drops in the treatment of perennial allergic conjunctivitis
    Ozod Nazarov
    Scientific Center for Allergy of Uzbekistan, Tashkent, Republic of Uzbekistan
    Arzneimittelforschung 53:167-73. 2003
    ..present double-blind study aimed to evaluate azelastine eye drops (Allergodil) in patients with perennial allergic conjunctivitis compared to placebo...
  94. ncbi Allergy and infections: long-term improvement of vernal keratoconjunctivitis following viral conjunctivitis
    R Sgrulletta
    Interdisciplinary Center for Biomedical Research CIR, Laboratory of Ophthalmology, University of Roma Campus Bio Medico and G B Bietti Eye Foundation, IRCCS, Roma Italy
    Eur J Ophthalmol 16:470-3. 2006
    ..Viral infection stimulates a Th1 type immune response, potentially attenuating allergen-induced inflammation. The purpose of this report is to describe the effect of viral keratoconjunctivitis in a patient with VKC...
  95. ncbi Effects of a new formulation of olopatadine ophthalmic solution on nasal symptoms relative to placebo in two studies involving subjects with allergic conjunctivitis or rhinoconjunctivitis
    Mark B Abelson
    Schepens Eye Research Institute, Boston, MA 01845, USA
    Curr Med Res Opin 21:683-91. 2005
    ..was evaluated in two separate, randomized, placebo-controlled, double-masked, hybrid environmental studies intended to determine efficacy and safety in subjects with histories of seasonal allergic conjunctivitis or rhinoconjunctivitis.
  96. ncbi Prevention of allergic eye disease by treatment with IL-1 receptor antagonist
    A M Keane-Myers
    Department of Ophthalmology, The Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 40:3041-6. 1999
    ..To determine the impact of interleukin-1 (IL-1) inhibition using IL-1 receptor antagonist (IL-1Ra) in a mouse model of allergic eye disease...
  97. ncbi Suppression of macrophage infiltration into the conjunctiva by clodronate liposomes in experimental immune-mediated blepharoconjunctivitis
    Atsuki Fukushima
    Laboratory of Immunology, Department of Ophthalmology, Kochi Medical School, Nankoku City, 783 8505 Japan
    Cell Biol Int 29:277-86. 2005
    Macrophages infiltrate the conjunctiva in severe cases of allergic conjunctivitis (AC) such as atopic keratoconjunctivitis (AKC)...
  98. ncbi Spectrum of ocular allergy
    Stefan D Trocme
    Department of Ophthalmology and Visual Sciences, University of Texas Medical School, Galveston, USA
    Curr Opin Allergy Clin Immunol 2:423-7. 2002
    ..To elaborate and review the immunologic spectrum of the five basic types of ocular allergy...
  99. ncbi Pharmacokinetic analysis of platelet-activating factor in the tears of guinea pigs with allergic conjunctivitis
    Naoki Okumura
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    J Ocul Pharmacol Ther 22:347-52. 2006
    The aim of this study was to examine the levels of platelet-activating factor (PAF) and lyso-PAF in tears from experimental animals developing allergic conjunctivitis (AC).
  100. ncbi Development of an animal model for allergic conjunctivitis: influence of genetic factors and allergen concentration on immune response
    Pedro Giavina-Bianchi
    Division of Clinical Immunology and Allergy, University of Sao Paulo, Sao Paulo, Brazil
    Acta Ophthalmol 86:670-5. 2008
    ..The present study aimed to develop an animal model that simulates human allergic conjunctivitis and to study how allergic response may be influenced by the allergen dose used for immunization and by ..
  101. ncbi Farm environment in childhood prevents the development of allergies
    M Kilpeläinen
    Departments of Pulmonary Diseases and Clinical Allergology, University of Turku, Finland
    Clin Exp Allergy 30:201-8. 2000
    ..A protective effect of infections in early life might explain the firmly reported finding of an inverse association between atopic disorders and large sibships...

Research Grants31

  1. ANTIGEN PRESENTATION--MODEL OF ALLERGIC EYE DISEASE
    Gilles Benichou; Fiscal Year: 2003
    ..We have recently developed a mouse model of allergic conjunctivitis to cat dander (Fel dl), and characterized the T helper responses in susceptible animals...
  2. THE IMMUNOBIOLOGY OF CORNEAL ALLOGRAFTS
    Jerry Niederkorn; Fiscal Year: 2013
    ..The first specific aim explores the immune mechanisms whereby allergic diseases such as asthma and allergic conjunctivitis abolish corneal immune privilege and profoundly increase the incidence and tempo of corneal allograft ..
  3. Conjunctival Goblet Cell Mucin Secretion in Inflammation and Its Resolution
    Darlene A Dartt; Fiscal Year: 2012
    ..of diseases of ocular surface inflammation and allergic inflammation such as dry eye and most forms of allergic conjunctivitis. Goblet cell mucins protect the ocular surface from the external environment and loss of filled goblet ..
  4. Roles of CC chemokine activity in mast cell responses and ocular allergy
    Santa Jeremy Ono; Fiscal Year: 2012
    ..specific aims: 1) to examine the mast cell-priming role of eotaxin-1-CCR3 activity in a murine model of allergic conjunctivitis; 2) to explore the costimulatory role of MIP-1[unreadable]-CCR1 signaling in mast cell activation in vivo;..
  5. Cellular and Molecular Mechanisms that Contribute to Ocular Surface Allergy
    DANIEL RAPHAEL SABAN; Fiscal Year: 2013
    PROJECT SUMMARY Allergic conjunctivitis (AC) affects nearly 30 million Americans, thereby constituting a major health problem and causing significant health care costs in the United States...
  6. PATHOGENESIS OF CONJUNCTIVITIS IN THE EYE
    SANTA ONO; Fiscal Year: 2000
    ..All data indicate that patients with allergic conjunctivitis share the same atopic condition with rhinitics and asthmatics...
  7. Interactions between ocular tissue and RSV
    Sailen Barik; Fiscal Year: 2004
    ..recent times, studies from our laboratory and others' have established a significant association between allergic conjunctivitis and the presence of RSV and cytokines in the eye...
  8. Advances in Allergy, Asthma and Immunology
    Leonard Bielory; Fiscal Year: 2002
    ..Summary: This application will provide the catalyst for establishing an ongoing forum for the review and promotion of scientifically based research assessing the impact of CAM in allergy, asthma and immunology. ..
  9. Cellular targets of IL-4 and IL-13 in worm expulsion
    Fred Finkelman; Fiscal Year: 2007
    ..It should also be useful for the intelligent prediction of risks associated with agents that inhibit allergic inflammation. ..
  10. FACTORS AFFECTING GROWTH OF BRUGIA MALAYI IN SCID MICE
    THIRUCHANDURAI RAJAN; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  11. The Role of Unc119 in T Cell Antigen Receptor Signaling1
    Rafeul Alam; Fiscal Year: 2008
    ..Further, it examines the molecular mechanism of idiopathic CD4 lymphopenia, which may pave the way to gene therapy for this rare immunodeficiency disorder. ..
  12. The Importance of the p38 MAP Kinase Signaling Pathways in Asthma
    Rafeul Alam; Fiscal Year: 2008
    ..Therapeutic interventions targeting the p38-MK2 pathway are likely to prevent asthma exacerbations induced with diverse triggers. ..
  13. Control of Conjuctival Goblet Cell Mucin Production
    Darlene Dartt; Fiscal Year: 2009
    ..Study of the signaling pathways that stimulate conjunctival goblet cell proliferation will lead to the development of treatments to replenish the mucin layer in these diseases. ..
  14. Environmentally-Induced Ocular Surface Inflammation Mimicking Sjogren's Syndrome
    Michael J Stern; Fiscal Year: 2010
    ..We further propose that the severity of this ALKC is worsened by defective self tolerance mechanisms. ..
  15. Direct IL-4 and IL-13 effects on pulmonary smooth muscle in allergic airway disea
    FRED DOUGLASS FINKELMAN; Fiscal Year: 2010
    ..Proposed studies with a mouse model in which airway hyperresponsiveness is induced solely by direct IL-4 and IL-13 effects on smooth muscle should help to elucidate these mechanisms and may reveal new approaches for asthma therapy. ..
  16. REGULATION OF IL4 PRODUCTION IN VIVO
    Fred Finkelman; Fiscal Year: 2002
    ..The results of these experiments will provide a better understanding of how IL-4 responses are regulated in vivo; this understanding will enhance the ability to control disorders that are regulated by IL-4. ..
  17. ENDOTHELIUM--SIGNALING FROM MAST CELLS TO EOSINOPHILS
    David Broide; Fiscal Year: 2002
    ....
  18. GROWTH OF B MALAYI IN MURINE MODELS--ROLE OF NK CELLS
    THIRUCHANDURAI RAJAN; Fiscal Year: 2001
    ..Identification of the molecule(s) involved in the interaction could help us formulate a rationale approach to immunoprophylaxis, as well as pharmacology of lymphatic filarial parasites. ..
  19. Role of Mouse Allergen in Childhood Asthma
    Wanda Phipatanakul; Fiscal Year: 2007
    ..This will help her translate knowledge gained from her research into direct community benefit. [unreadable] [unreadable]..
  20. Role of Inflammatory Cytokines in the Allergic Response
    Fred Finkelman; Fiscal Year: 2007
    ..abstract_text> ..
  21. IL4R AND IMMUNITY TO GI NEMATODE PARASITES
    Fred Finkelman; Fiscal Year: 2003
    ....
  22. RSV AND ASTHMA
    David Broide; Fiscal Year: 2003
    ..Overall these studies will contribute to our understanding of the mechanism of eosinophilic inflammation during RSV infection and suggest candidate vaccine strategies to inhibit RSV infection and airway inflammation. ..
  23. CYTOKINE REGULATION OF A MOUSE MODEL OF ASTHMA
    Fred Finkelman; Fiscal Year: 2003
    ..By clarifying the mechanisms by which cytokines induce pulmonary inflammation and airway responsiveness, the proposed studies will provide information important for rational therapy for asthma. ..
  24. FACTORS AFFECTING GROWTH OF BRUGIA MALAVI IN SCID MICE
    THIRUCHANDURAI RAJAN; Fiscal Year: 2005
    ....
  25. Brugia Infections in Mice: Role of Eosinophils
    THIRUCHANDURAI RAJAN; Fiscal Year: 2005
    ..We believe that the studies proposed herein will help us understand the mechanisms by which mammalian hosts combat infectious agents that are far larger than their own effector cells. ..
  26. Eosinophil Trafficking
    David Broide; Fiscal Year: 2005
    ..Overall, these studies should improve our understanding of the molecular mechanism of eosinophil recruitment in vivo and its effect on airway structure and function. ..
  27. The Signal Transduction Mechanism of Interleukin-5
    Rafeul Alam; Fiscal Year: 2005
    ..Lyn and IRIP may represent excellent therapeutic targets for intervention in asthma and other allergic diseases. ..
  28. IMMUNE MECHANISMS OF MIDDLE EAR DISEASE
    David Skoner; Fiscal Year: 2006
    ..The primary hypothesis is that cytokine genotype is predictive of illness expression and of OM incidence during a documented RSV infection in young children. ..
  29. Planning Grant:Research on Blinding Eye Diseases (RMI)
    Darlene Dartt; Fiscal Year: 2006
    ..Based on these findings, an application for an Interdisciplinary Center for Research on Blinding Eye Diseases will be prepared. [unreadable] [unreadable]..
  30. Biomarkers in sputum in COPD
    David Broide; Fiscal Year: 2005
    ..abstract_text> ..