hypothyroidism

Summary

Summary: A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA.

Top Publications

  1. ncbi Cardiovascular effects of mild hypothyroidism
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Naples, Italy
    Thyroid 17:625-30. 2007
  2. pmc Variants near FOXE1 are associated with hypothyroidism and other thyroid conditions: using electronic medical records for genome- and phenome-wide studies
    Joshua C Denny
    Department of Biomedical Informatics, Vanderbilt University, Nashville, TN 37232, USA
    Am J Hum Genet 89:529-42. 2011
  3. ncbi Subclinical thyroid disease: scientific review and guidelines for diagnosis and management
    Martin I Surks
    Department of Medicine, Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, NY 10467 2490, USA
    JAMA 291:228-38. 2004
  4. ncbi Subclinical hypothyroidism and pregnancy outcomes
    Brian M Casey
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9032, USA
    Obstet Gynecol 105:239-45. 2005
  5. ncbi The clinical significance of subclinical thyroid dysfunction
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
    Endocr Rev 29:76-131. 2008
  6. ncbi Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association
    Jeffrey R Garber
    Endocrine Division, Harvard Vanguard Medical Associates, Boston, Massachusetts 02215, USA
    Endocr Pract 18:988-1028. 2012
  7. ncbi Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association
    Jeffrey R Garber
    Endocrine Division, Harvard Vanguard Medical Associates, Boston, Massachusetts 02215, USA
    Thyroid 22:1200-35. 2012
  8. ncbi Prospective evaluation of the natural course of idiopathic subclinical hypothyroidism in childhood and adolescence
    Malgorzata Wasniewska
    Department of Pediatrics, University of Messina, Messina, Italy
    Eur J Endocrinol 160:417-21. 2009
  9. ncbi Linear growth and intellectual outcome in children with long-term idiopathic subclinical hypothyroidism
    Manuela Cerbone
    Department of Pediatrics, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
    Eur J Endocrinol 164:591-7. 2011
  10. ncbi Neurodevelopmental and neurophysiological actions of thyroid hormone
    G R Williams
    Molecular Endocrinology Group, Division of Medicine and MRC Clinical Sciences Centre, Imperial College, London, UK
    J Neuroendocrinol 20:784-94. 2008

Detail Information

Publications347 found, 100 shown here

  1. ncbi Cardiovascular effects of mild hypothyroidism
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Naples, Italy
    Thyroid 17:625-30. 2007
    The cardiovascular risk is increased in patients with overt hypothyroidism, and several potential cardiovascular risk factors were similarly reported in patients with subclinical hypothyroidism...
  2. pmc Variants near FOXE1 are associated with hypothyroidism and other thyroid conditions: using electronic medical records for genome- and phenome-wide studies
    Joshua C Denny
    Department of Biomedical Informatics, Vanderbilt University, Nashville, TN 37232, USA
    Am J Hum Genet 89:529-42. 2011
    ..the Electronic Medical Records and Genomics network to perform a genome-wide association study for primary hypothyroidism, the most common thyroid disease...
  3. ncbi Subclinical thyroid disease: scientific review and guidelines for diagnosis and management
    Martin I Surks
    Department of Medicine, Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, NY 10467 2490, USA
    JAMA 291:228-38. 2004
    ..The necessity for further evaluation, possible treatment, and the urgency of treatment have not been clearly established...
  4. ncbi Subclinical hypothyroidism and pregnancy outcomes
    Brian M Casey
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9032, USA
    Obstet Gynecol 105:239-45. 2005
    ..The relationship between subclinical hypothyroidism and pregnancy outcomes has not been well studied...
  5. ncbi The clinical significance of subclinical thyroid dysfunction
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
    Endocr Rev 29:76-131. 2008
    ..However, the clinical significance of subclinical thyroid dysfunction is much debated. Subclinical hyper- and hypothyroidism can have repercussions on the cardiovascular system and bone, as well as on other organs and systems...
  6. ncbi Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association
    Jeffrey R Garber
    Endocrine Division, Harvard Vanguard Medical Associates, Boston, Massachusetts 02215, USA
    Endocr Pract 18:988-1028. 2012
    b>Hypothyroidism has multiple etiologies and manifestations. Appropriate treatment requires an accurate diagnosis and is influenced by coexisting medical conditions...
  7. ncbi Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association
    Jeffrey R Garber
    Endocrine Division, Harvard Vanguard Medical Associates, Boston, Massachusetts 02215, USA
    Thyroid 22:1200-35. 2012
    b>Hypothyroidism has multiple etiologies and manifestations. Appropriate treatment requires an accurate diagnosis and is influenced by coexisting medical conditions...
  8. ncbi Prospective evaluation of the natural course of idiopathic subclinical hypothyroidism in childhood and adolescence
    Malgorzata Wasniewska
    Department of Pediatrics, University of Messina, Messina, Italy
    Eur J Endocrinol 160:417-21. 2009
    To prospectively evaluate the course of subclinical hypothyroidism (SH) in children and adolescents with no underlying diseases and no risk factors, which might interfere with the progression of SH.
  9. ncbi Linear growth and intellectual outcome in children with long-term idiopathic subclinical hypothyroidism
    Manuela Cerbone
    Department of Pediatrics, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
    Eur J Endocrinol 164:591-7. 2011
    The treatment of children with subclinical hypothyroidism (SH) is controversial for TSH values between 4.5 and 10 mU/l...
  10. ncbi Neurodevelopmental and neurophysiological actions of thyroid hormone
    G R Williams
    Molecular Endocrinology Group, Division of Medicine and MRC Clinical Sciences Centre, Imperial College, London, UK
    J Neuroendocrinol 20:784-94. 2008
    ..Clinical observations of good neurological outcome following early treatment of congenital hypothyroidism were used to support the view that thyroid hormones are not required early in neurodevelopment...
  11. ncbi Thyroid V30 predicts radiation-induced hypothyroidism in patients treated with sequential chemo-radiotherapy for Hodgkin's lymphoma
    Laura Cella
    Institute of Biostructures and Bioimages, National Council of Research CNR, Naples, Italy
    Int J Radiat Oncol Biol Phys 82:1802-8. 2012
    b>Hypothyroidism (HT) is a frequent late side effect of Hodgkin's lymphoma (HL) therapy...
  12. pmc Excess mortality in patients diagnosed with hypothyroidism: a nationwide cohort study of singletons and twins
    Marianne Thvilum
    Department of Endocrinology and Metabolism, Odense University Hospital, Kløvervænget 6, 5000 Odense C, Denmark
    J Clin Endocrinol Metab 98:1069-75. 2013
    Although hypothyroidism is associated with increased morbidity, an association with increased mortality is still debated. Our objective was to investigate, at a nationwide level, whether a diagnosis of hypothyroidism influences mortality.
  13. ncbi A randomized controlled trial of the effect of thyroxine replacement on cognitive function in community-living elderly subjects with subclinical hypothyroidism: the Birmingham Elderly Thyroid study
    J Parle
    School of Health and Population Sciences, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B152TT, United Kingdom
    J Clin Endocrinol Metab 95:3623-32. 2010
    Subclinical hypothyroidism (SCH) and cognitive dysfunction are both common in the elderly and have been linked. It is important to determine whether T4 replacement therapy in SCH confers cognitive benefit.
  14. ncbi Age-specific distribution of serum thyrotropin and antithyroid antibodies in the US population: implications for the prevalence of subclinical hypothyroidism
    Martin I Surks
    Department of Medicine, Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, New York 10467, USA
    J Clin Endocrinol Metab 92:4575-82. 2007
    ..The TSH median, 97.5 centile and prevalence of subclinical hypothyroidism (SCH), normal serum T(4) and TSH greater than 4.5 mIU/liter, increased progressively with age...
  15. pmc Anxiety, memory impairment, and locomotor dysfunction caused by a mutant thyroid hormone receptor alpha1 can be ameliorated by T3 treatment
    Cesar Venero
    Psychobiology Department, Universidad Nacional de Educacion a Distancia, 28040 Madrid, Spain
    Genes Dev 19:2152-63. 2005
    ..properties of unliganded thyroid hormone receptors are thought to cause the misdevelopment during hypothyroidism of several functions essential for adult life...
  16. ncbi Psychological well-being in patients on 'adequate' doses of l-thyroxine: results of a large, controlled community-based questionnaire study
    P Saravanan
    Weston General Hospital, Weston Super Mare, Bristol, UK
    Clin Endocrinol (Oxf) 57:577-85. 2002
    ..To date there has been no large study to determine whether this is related to thyroxine replacement or coincidental psychological morbidity. We have therefore attempted to address this issue using a large, community-based study...
  17. ncbi Brain glucose metabolism in hypothyroidism: a positron emission tomography study before and after thyroid hormone replacement therapy
    M Bauer
    Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus Dresden, Technische Universitat Dresden, Fetscherstrasse 74, Dresden, Germany
    J Clin Endocrinol Metab 94:2922-9. 2009
    b>Hypothyroidism is frequently associated with subtle behavioral and psychiatric symptoms. The consequences of inadequate thyroid hormone availability to brain metabolism are poorly understood.
  18. pmc Subclinical hypothyroidism and the risk of coronary heart disease and mortality
    Nicolas Rodondi
    Department of Ambulatory Care and Community Medicine, University of Lausanne, Bugnon 44, 1011 Lausanne, Switzerland
    JAMA 304:1365-74. 2010
    Data regarding the association between subclinical hypothyroidism and cardiovascular disease outcomes are conflicting among large prospective cohort studies...
  19. ncbi Subclinical hypothyroidism and the risk of heart failure, other cardiovascular events, and death
    Nicolas Rodondi
    Department of Epidemiology and Biostatistics, University of California, San Francisco, USA
    Arch Intern Med 165:2460-6. 2005
    Subclinical hypothyroidism has been associated with systolic and diastolic cardiac dysfunction and an elevated cholesterol level, but data on cardiovascular outcomes and death are limited.
  20. ncbi Effect of iodine intake on thyroid diseases in China
    Weiping Teng
    Department of Endocrinology and Metabolism, First Affiliated Hospital, China Medical University, Shengyang, China
    N Engl J Med 354:2783-93. 2006
    ..We observed an increase in the prevalence of overt hypothyroidism, subclinical hypothyroidism, and autoimmune thyroiditis with increasing iodine intake in China in cohorts from ..
  21. pmc Thyroid status, cardiovascular risk, and mortality in older adults
    Anne R Cappola
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
    JAMA 295:1033-41. 2006
    ..Previous studies have suggested that subclinical abnormalities in thyroid-stimulating hormone levels are associated with detrimental effects on the cardiovascular system...
  22. ncbi Is age a risk factor for hypothyroidism in pregnancy? An analysis of 5223 pregnant women
    Eliska Potlukova
    Third Department of Medicine, General University Hospital and First Faculty of Medicine, Charles University in Prague, U Nemocnice 1, Prague 2, 128 08, Czech Republic
    J Clin Endocrinol Metab 97:1945-52. 2012
    The guidelines of American Thyroid Association from 2011 include age over 30 as one of the risk factors for hypothyroidism in pregnancy.
  23. ncbi Significance of (sub)clinical thyroid dysfunction and thyroid autoimmunity before conception and in early pregnancy: a systematic review
    Emmy VAN DEN Boogaard
    Department of Obstetrics and Gynaecology, Academic Medical Center, Centre for Reproductive Medicine, Amsterdam, The Netherlands
    Hum Reprod Update 17:605-19. 2011
    ..We conducted a systematic review of the literature on the clinical significance of thyroid dysfunction and thyroid autoimmunity before conception and in early pregnancy...
  24. pmc Novel associations for hypothyroidism include known autoimmune risk loci
    Nicholas Eriksson
    23andMe, Inc, Mountain View, California, United States of America
    PLoS ONE 7:e34442. 2012
    b>Hypothyroidism is the most common thyroid disorder, affecting about 5% of the general population. Here we present the current largest genome-wide association study of hypothyroidism, in 3,736 cases and 35,546 controls...
  25. ncbi A review of the evidence for and against increased mortality in hypothyroidism
    Marianne Thvilum
    Department of Endocrinology and Metabolism, Odense University Hospital, Kløvervænget 6, 5000 Odense C, Denmark
    Nat Rev Endocrinol 8:417-24. 2012
    The lifetime risk of overt hypothyroidism is around 5%, and this disease is usually preceded by subclinical hypothyroidism, which has an even higher prevalence (estimated to be up to 9%)...
  26. ncbi Combination treatment with T4 and T3: toward personalized replacement therapy in hypothyroidism?
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 97:2256-71. 2012
    ..T(4) treatment to improve the quality of life, cognition, and peripheral parameters of thyroid hormone action in hypothyroidism. The aim of this review is to assess the physiological basis and the results of current studies on this topic.
  27. ncbi Permanent and transient congenital hypothyroidism in Isfahan-Iran
    Mahin Hashemipour
    Endocrinology, Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Sedigheh Tahereh Medical Research Complex, Khorram Street, Jomhouri Square, Isfahan 8187698191, Iran
    J Med Screen 16:11-6. 2009
    To determine the prevalence of permanent and transient congenital hypothyroidism (CH) in Isfahan, Iran.
  28. ncbi Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism
    Jose C Moreno
    Department of Pediatric Endocrinology, Emma Children s Hospital, Academic Medical Center, University of Amsterdam, Amsterdam
    N Engl J Med 347:95-102. 2002
    Several genetic defects are associated with permanent congenital hypothyroidism. Immunologic, environmental, and iatrogenic (but not genetic) factors are known to induce transient congenital hypothyroidism, which spontaneously resolves ..
  29. ncbi Raised serum TSH levels in patients with morbid obesity: is it enough to diagnose subclinical hypothyroidism?
    Mario Rotondi
    Unit of Internal Medicine and Endocrinology, Fondazione Salvatore Maugeri IRCCS, ISPESL Laboratory for Endocrine Disruptors, Chair of Endocrinology, University of Pavia, Pavia, Italy
    Eur J Endocrinol 160:403-8. 2009
    ..BMI)> or =40 kg/m(2)) is associated with thyroid function disturbances, with a high rate of subclinical hypothyroidism (SH) being the most consistently reported...
  30. pmc Thyrotropin levels in a population with no clinical, autoantibody, or ultrasonographic evidence of thyroid disease: implications for the diagnosis of subclinical hypothyroidism
    Thomas E Hamilton
    Program in Epidermology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    J Clin Endocrinol Metab 93:1224-30. 2008
    The current debate regarding whether to decrease the upper limit for the TSH reference range to 2.5 microIU/ml has considerable potential impact on the diagnosis and treatment of subclinical hypothyroidism worldwide.
  31. ncbi Lipoprotein profile in subclinical hypothyroidism: response to levothyroxine replacement, a randomized placebo-controlled study
    Nadia Caraccio
    Metabolism Unit, Department of Internal Medicine, University of Pisa School of Medicine, 56126 Pisa, Italy
    J Clin Endocrinol Metab 87:1533-8. 2002
    The relationship between subclinical hypothyroidism (SCH) and an atherogenic lipoprotein profile is still controversial. We measured lipoproteins in 49 SCH patients by comparison with 33 euthyroid controls...
  32. ncbi The incidence of ischemic heart disease and mortality in people with subclinical hypothyroidism: reanalysis of the Whickham Survey cohort
    Salman Razvi
    Department of Endocrinology, Gateshead Health National Health Service Foundation Trust, Gateshead NE9 6SX, United Kingdom
    J Clin Endocrinol Metab 95:1734-40. 2010
    ..heart disease (IHD) and a composite autoimmune thyroid disease group, comprising individuals with subclinical hypothyroidism (SCH), with positive thyroid antibodies or those using levothyroxine, was found...
  33. ncbi Regression of the increased common carotid artery-intima media thickness in subclinical hypothyroidism after thyroid hormone replacement
    Soo Kyung Kim
    Department of Internal Medicine, CHA University School of Medicine, Sungnam, Korea
    Endocr J 56:753-8. 2009
    The association between subclinical hypothyroidism and cardiovascular disease and the beneficial effect of levothyroxine replacement in subclinical hypothyroidism are still under debate...
  34. ncbi Effects of thyroid hormone on the cardiovascular system
    Serafino Fazio
    Department of Clinical Medicine and Cardiovascular Sciences, University of Naples Federico II School of Medicine, 80131, Naples, Italy
    Recent Prog Horm Res 59:31-50. 2004
    ..and increased prevalence of supraventricular tachyarrhythmias - namely, atrial fibrillation - whereas overt hypothyroidism is characterized by the opposite changes...
  35. ncbi Lipid profile in subclinical hypothyroidism: is L-thyroxine substitution beneficial?
    Z Efstathiadou
    Division of Endocrinology, University of Ioannina School of Medicine, University Hospital of Ioannina, Ioannina, Greece
    Eur J Endocrinol 145:705-10. 2001
    The significance of dyslipidemia in subclinical hypothyroidism (SH) and the effect of thyroid substitution on lipids remain controversial...
  36. ncbi Thyroid developmental anomalies in first degree relatives of children with congenital hypothyroidism
    Juliane Leger
    Pediatric Endocrinology Unit and INSERM U457, Hopital Robert Debre, 75019 Paris, France
    J Clin Endocrinol Metab 87:575-80. 2002
    Congenital hypothyroidism (CH) is most frequently caused by thyroid developmental abnormalities and it has recently been seen to have a familial component...
  37. ncbi Maternal thyroid hypofunction and pregnancy outcome
    Jane Cleary-Goldman
    Columbia University Medical Center, New York, NY, USA
    Obstet Gynecol 112:85-92. 2008
    ..To estimate whether maternal thyroid hypofunction is associated with complications...
  38. ncbi Prevalence of congenital hypothyroidism in Isfahan, Iran: results of a survey on 20,000 neonates
    Mahin Hashemipour
    Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences and Health Services, Isfahan, Iran
    Horm Res 62:79-83. 2004
    To evaluate the prevalence of congenital hypothyroidism (CH) in a screening program performed for the first time in Isfahan, Iran.
  39. ncbi Impaired endothelium-dependent vasodilatation in subclinical hypothyroidism: beneficial effect of levothyroxine therapy
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, 56100 Pisa, Italy
    J Clin Endocrinol Metab 88:3731-7. 2003
    Subclinical hypothyroidism (sHT) is associated with enhanced cardiovascular risk...
  40. ncbi Role of thyroid hormone during early brain development
    Gabriella Morreale de Escobar
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas CSIC y Universidad Autonoma de Madrid UAM, Arturo Duperier, 4, 28029 Madrid, Spain
    Eur J Endocrinol 151:U25-37. 2004
    ....
  41. ncbi Hypothyroidism
    Caroline G P Roberts
    Division of Endocrinology and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Lancet 363:793-803. 2004
    b>Hypothyroidism is common, potentially serious, often clinically overlooked, readily diagnosed by laboratory testing, and eminently treatable. The condition is particularly prevalent in older women, in whom autoimmune thyroiditis is common...
  42. ncbi Epidemiology and prevention of clinical and subclinical hypothyroidism
    Mark P J Vanderpump
    Department of Endocrinology, Royal Free Hospital, London, United Kingdom
    Thyroid 12:839-47. 2002
    Iodine deficiency is the most common cause of hypothyroidism worldwide...
  43. ncbi 3,5-Diiodo-L-thyronine rapidly enhances mitochondrial fatty acid oxidation rate and thermogenesis in rat skeletal muscle: AMP-activated protein kinase involvement
    A Lombardi
    Università degli Studi del Napoli, Federic II, Napoli, Italy
    Am J Physiol Endocrinol Metab 296:E497-502. 2009
    ....
  44. ncbi Natural history of mild subclinical hypothyroidism: prognostic value of ultrasound
    Pedro W S Rosário
    Department of Thyroid, Endocrinology Service, Santa Casa de Belo Horizonte, Minas Gerais, Brazil
    Thyroid 19:9-12. 2009
    Clinical repercussions, progression to overt hypothyroidism, and treatment benefits have been well established in patients with subclinical hypothyroidism (SCH) and TSH >10 mIU/L...
  45. ncbi Evaluation of new measures of the impact of hypothyroidism on quality of life and symptoms: the ThyDQoL and ThySRQ
    Carolyn McMillan
    Royal Holloway, University of London, Egham, Surrey, UK
    Value Health 11:285-94. 2008
    ..Thyroid-Dependent Quality of Life Questionnaire (ThyDQoL) individualized measure of perceived impact of hypothyroidism on quality of life (QoL); and 2) the 15-item Underactive Thyroid Symptom Rating Questionnaire (ThySRQ), in ..
  46. ncbi Lower neonatal screening thyroxine concentrations in down syndrome newborns
    A S P van Trotsenburg
    Department of Pediatric Endocrinology, Emma Children s Hospital AMC, 1105 AZ Amsterdam, The Netherlands
    J Clin Endocrinol Metab 88:1512-5. 2003
    There is an unexplained higher incidence of congenital hypothyroidism (CH) detected by T(4)-based neonatal screening programs and a very high prevalence of (mild) plasma TSH elevation in young children with Down syndrome (DS)...
  47. ncbi Is hypothyroidism a risk factor for non-alcoholic steatohepatitis?
    Suthat Liangpunsakul
    Mount Sinai School of Medicine, Bronx, New York 10468, USA
    J Clin Gastroenterol 37:340-3. 2003
    ..Anecdotally, we have observed that a number of patients with NASH carried a diagnosis of hypothyroidism. However, it is unknown if thyroid dysfunction plays any role in the pathogenesis of NASH...
  48. ncbi Germline mutations of TSH receptor gene as cause of nonautoimmune subclinical hypothyroidism
    Luisella Alberti
    Institute of Endocrine Sciences, University of Milan, Istituto Auxologico Italiano Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, 20145 Milan, Italy
    J Clin Endocrinol Metab 87:2549-55. 2002
    ..Germline mutations of TSHR may be associated with serum TSH values fluctuating above the upper limit of the normal range, also in the heterozygous state...
  49. ncbi Longitudinal growth, sexual maturation and final height in patients with congenital hypothyroidism detected by neonatal screening
    M Salerno
    Department of Pediatrics, University of Naples Federico II, Italy
    Eur J Endocrinol 145:377-83. 2001
    To evaluate longitudinal growth, pubertal development and final height in patients with congenital hypothyroidism (CH) detected by a neonatal screening programme, and to identify factors potentially affecting growth outcome.
  50. ncbi National status of testing for hypothyroidism during pregnancy and postpartum
    Amy J Blatt
    Quest Diagnostics, West Norriton, PA 19403, USA
    J Clin Endocrinol Metab 97:777-84. 2012
    b>Hypothyroidism, overt or subclinical, is associated with adverse outcomes for pregnant women and their offspring. Knowledge of current national thyroid testing rates and positivity during pregnancy is limited.
  51. ncbi More than adequate iodine intake may increase subclinical hypothyroidism and autoimmune thyroiditis: a cross-sectional study based on two Chinese communities with different iodine intake levels
    Xiaochun Teng
    Department of Endocrinology and Metabolism, The First Affiliated Hospital, China Medical University, No 155 Nanjing Bei Street, Heping District, Shenyang, People s Republic of China
    Eur J Endocrinol 164:943-50. 2011
    ..g. thyroid dysfunction, thyroid autoimmunity, and thyroid structure) in two Chinese populations...
  52. ncbi Methimazole-induced hypothyroidism in rats ameliorates oxidative injury in experimental colitis
    C A Işman
    Department of Physiology, Marmara University, School of Medicine, 34716 Haydarpaşa, Istanbul, Turkey
    J Endocrinol 177:471-6. 2003
    Depression of metabolism by hypothyroidism decreases oxidant production and thus protects tIssues against oxidant damage. Moreover, it is well-known that abnormal gut motility is a common manifestation in hypo/hyperthyroidism...
  53. ncbi Increased serum CXCL10 in Graves' disease or autoimmune thyroiditis is not associated with hyper- or hypothyroidism per se, but is specifically sustained by the autoimmune, inflammatory process
    Alessandro Antonelli
    Metabolism Unit, Department of Internal Medicine and CNR Institute of Clinical Physiology, University of Pisa School of Medicine, Via Roma, 67, I 56100, Pisa, Italy
    Eur J Endocrinol 154:651-8. 2006
    ..Longitudinal assessment of sCXCL10 in autoimmune hypo- or hyperthyroidism has not yet been performed...
  54. ncbi Neonatal screening for congenital hypothyroidism in West Black Sea area, Turkey
    E Simsek
    Abant Izzet Baysal University, Duzce School of Medicine, Department of Pediatrics, Duzce, Turkey
    Int J Clin Pract 59:336-41. 2005
    The aim of this study was to investigate the incidence of congenital hypothyroidism (CH) in the West Black Sea Area, a mild-to-moderate iodine deficient area in Turkey...
  55. pmc Development of multivariate NTCP models for radiation-induced hypothyroidism: a comparative analysis
    Laura Cella
    Institute of Biostructures and Bioimaging, National Council of Research CNR, Naples, Italy
    Radiat Oncol 7:224. 2012
    b>Hypothyroidism is a frequent late side effect of radiation therapy of the cervical region...
  56. pmc Longitudinal study of thyroid function in Down's syndrome in the first two decades
    P A Gibson
    Department of Paediatrics, Royal Lancaster Infirmary, Lancaster, UK
    Arch Dis Child 90:574-8. 2005
    ..4 years). At the second test two were hypothyroid and two with isolated raised thyroid stimulating hormone (IR-TSH) were receiving thyroxine...
  57. ncbi Association between development of hypothyroidism and improved survival in patients with head and neck cancer
    Marc Nelson
    Head and Neck Institute, and Department of Radiation Oncology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Arch Otolaryngol Head Neck Surg 132:1041-6. 2006
    To determine if the development of hypothyroidism has an effect on the outcome of advanced-stage head and neck squamous cell carcinoma.
  58. ncbi Overt and subclinical hypothyroidism complicating pregnancy
    M Abalovich
    Division Endocrinologia, Hospital C Durand, Buenos Aires, Argentina
    Thyroid 12:63-8. 2002
    We studied the evolution of 150 pregnancies corresponding to 114 women (16-39 years old) with primary hypothyroidism. Fifty-one pregnancies (34%) were conceived under hypothyroidism: 16 overt (X +/- standard deviation [SD], thyroxine [T4]:..
  59. ncbi Rapid regulation of thyroid sodium-iodide symporter activity by thyrotrophin and iodine
    Andrea C F Ferreira
    Laboratório de Fisiologia Endócrina, Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    J Endocrinol 184:69-76. 2005
    ..Therefore, our data show that modulation of the thyroid NIS by TSH depends primarily on thyroid iodine content and, further, that the regulation of NIS activity is rapid...
  60. ncbi Role of ultrasonography in outcome prediction in subclinical hypothyroid patients treated with levothyroxine
    Dong Yeob Shin
    Endocrinology, Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    Endocr J 57:15-22. 2010
    Progression to overt hypothyroidism and the associated adverse effects on lipid metabolism and the cardiovascular system are major concerns for patients diagnosed with subclinical hypothyroidism (SCH)...
  61. pmc Genetics and phenomics of hypothyroidism and goiter due to NIS mutations
    Christine Spitzweg
    Department of Internal Medicine II, Klinikum Grosshadern, Ludwig Maximilians University Munich, Germany
    Mol Cell Endocrinol 322:56-63. 2010
    Molecular cloning of the NIS gene in 1996 allowed examination of the molecular basis of congenital hypothyroidism due to iodide transport defect (ITD) many years after the first case was described by Federman et al. in 1958...
  62. ncbi Meta-analysis: subclinical thyroid dysfunction and the risk for coronary heart disease and mortality
    Nicolas Ochs
    University of Lausanne, Lausanne, Switzerland
    Ann Intern Med 148:832-45. 2008
    ..Data on the association between subclinical thyroid dysfunction and coronary heart disease (CHD) and mortality are conflicting...
  63. ncbi Mutations of the human thyrotropin receptor gene causing thyroid hypoplasia and persistent congenital hypothyroidism
    H Biebermann
    Klinik und Poliklinik für Kinderheilkunde, Virchow Klinikum, Humboldt Unversität zu Berlin, Germany
    J Clin Endocrinol Metab 82:3471-80. 1997
    The pathogenesis of congenital hypothyroidism due to thyroid dysgenesis is still unknown. A point mutation in the TSH receptor (TSHR) of the hypothyroid hyt/hyt mouse invoked the TSHR as a candidate gene for congenital hypothyroidism...
  64. ncbi Impact of beta-myosin heavy chain isoform expression on cross-bridge cycling kinetics
    Veronica L M Rundell
    Center for Cardiovascular Research, Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Am J Physiol Heart Circ Physiol 288:H896-903. 2005
    ..05 (ANOVA)] Thus cross-bridge cycling, under high strain, for alpha-MHC is three times higher than for beta-MHC. Furthermore, under isometric conditions, alpha-MHC and beta-MHC cross bridges hydrolyze ATP independently of one another...
  65. pmc Serum resistin and high sensitive CRP levels in patients with subclinical hypothyroidism before and after L-thyroxine therapy
    Duygu Yazgan Aksoy
    Etlik Ihtisas Research and Training Hospital, Department of Endocrinology and Metabolism, Etlik, Ankara, Turkey
    Med Sci Monit 19:210-5. 2013
    Subclinical hypothyroidism (SH) is defined by increased thyrotropin (TSH) and normal free thyroxine (fT4) and free triiodothyronine (fT3) levels...
  66. pmc A lack of thyroid hormones rather than excess thyrotropin causes abnormal skeletal development in hypothyroidism
    J H Duncan Bassett
    Molecular Endocrinology Group, Medical Research Council Clinical Sciences Centre, Hammersmith Hospital, Du Cane Road, London, United Kingdom
    Mol Endocrinol 22:501-12. 2008
    ..importance of T(3) and TSH in bone, we compared the skeletal phenotypes of two mouse models of congenital hypothyroidism in which the normal reciprocal relationship between thyroid hormones and TSH was intact or disrupted...
  67. pmc Management of axitinib (AG-013736)-induced fatigue and thyroid dysfunction, and predictive biomarkers of axitinib exposure: results from phase I studies in Japanese patients
    Yutaka Fujiwara
    Medical Oncology Hematology, Department of Medicine, Kobe University Hospital, 7 5 2, Kusunoki cho, Chuo Ku, Kobe, 650 0017, Japan
    Invest New Drugs 30:1055-64. 2012
    ..We report on data obtained from 18 Japanese patients with advanced solid tumors in two phase I trials that evaluated the safety, pharmacokinetics and antitumor activity of axitinib and also examined potential biomarkers...
  68. ncbi Endogenous subclinical thyroid disorders, physical and cognitive function, depression, and mortality in older individuals
    Renate T de Jongh
    Department of Internal Medicine and Endocrinology EMGO Institute for Health and Care Research Department of Psychiatry, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Eur J Endocrinol 165:545-54. 2011
    ..To what extent endogenous subclinical thyroid disorders contribute to impaired physical and cognitive function, depression, and mortality in older individuals remains a matter of debate...
  69. ncbi Non-alcoholic fatty liver disease across the spectrum of hypothyroidism
    Goh Eun Chung
    Department of Internal Medicine, Healthcare Research Institute, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, South Korea
    J Hepatol 57:150-6. 2012
    The aim of this study was to characterize the relationship between the broad spectrum of hypothyroidism and NAFLD.
  70. ncbi Blood coagulation and fibrinolytic activity in hypothyroidism
    C Erem
    Department of Internal Medicine, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey
    Int J Clin Pract 57:78-81. 2003
    The influence of hypothyroidism on haemostasis is controversial; both hypocoagulable and hypercoagulable states have been reported...
  71. ncbi Spontaneous normalization of thyrotropin concentrations in patients with subclinical hypothyroidism
    Juan J Diez
    Department of Endocrinology, Hospital Ramon y Cajal, Carretera Colmenar km 9, 28034 Madrid, Spain
    J Clin Endocrinol Metab 90:4124-7. 2005
    Patients with subclinical hypothyroidism may revert to normal TSH values.
  72. pmc MiR-224 targets the 3'UTR of type 1 5'-iodothyronine deiodinase possibly contributing to tissue hypothyroidism in renal cancer
    Joanna Boguslawska
    Department of Biochemistry and Molecular Biology, The Medical Centre of Postgraduate Education, Warsaw, Poland
    PLoS ONE 6:e24541. 2011
    ..Finally, induced expression of miR-224 in Caki-2 cells resulted in significant (p<0.01) reduction of DIO1 mRNA. This study provides a novel miRNA-mediated regulatory mechanism of DIO1 expression in ccRCC...
  73. ncbi Dietary thyroid hormone replacement ameliorates hearing deficits in hypothyroid mice
    I Jill Karolyi
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan 48109 0618, USA
    Mamm Genome 18:596-608. 2007
    ..We conclude that TH supplement administered during the critical period of hearing development in mice can prevent deafness associated with congenital hypothyroidism of heterogeneous genetic etiology.
  74. ncbi Genetics and phenomics of hypothyroidism and goiter due to TPO mutations
    Carrie Ris-Stalpers
    Laboratory for Reproductive Biology, Academic Medical Center G2 133, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Mol Cell Endocrinol 322:38-43. 2010
    ..Inactivating mutations form the molecular basis for a specific subtype of congenital hypothyroidism: thyroid dyshormonogenesis due to an iodide organification defect...
  75. ncbi Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society Clinical Practice Guideline
    Marcos Abalovich
    Endocrinology Division, Durand Hospital, Buenos Aires, Argentina
    J Clin Endocrinol Metab 92:S1-47. 2007
    ..The objective is to provide clinical guidelines for the management of thyroid problems present during pregnancy and in the postpartum...
  76. pmc Levothyroxine dose and risk of fractures in older adults: nested case-control study
    Marci R Turner
    Department of Medicine, University of Toronto, Canada
    BMJ 342:d2238. 2011
    ..To quantify the effect of levothyroxine dose on risk of fractures in older adults...
  77. ncbi Induced hypothyroidism accelerates the regression of liver fibrosis in rats
    Rafael Bruck
    Department of Gastrointestinal and Liver Diseases, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    J Gastroenterol Hepatol 22:2189-94. 2007
    It has been shown in previous studies that hypothyroidism prevents the development of liver fibrosis in bile duct ligated rats and in rats chronically treated with thioacetamide (TAA)...
  78. ncbi Thyroid hormone early adjustment in pregnancy (the THERAPY) trial
    Leila Yassa
    Thyroid Unit, Division of Endocrinology, Metabolism, and Diabetes, Brigham and Women s Hospital, 75 Francis Street, Room PBB B4, Boston, MA 02115, USA
    J Clin Endocrinol Metab 95:3234-41. 2010
    Thyroid hormone requirement increases 20-40% during gestation. Women with treated hypothyroidism must increase their l-T(4) in pregnancy to prevent maternal hypothyroidism, although how this should be accomplished is unclear.
  79. ncbi Serum lipid levels in relation to serum thyroid-stimulating hormone and the effect of thyroxine treatment on serum lipid levels in subjects with subclinical hypothyroidism: the Tromsø Study
    A Iqbal
    Department of Cardiology, University Hospital of North Norway, Tromsø, Norway
    J Intern Med 260:53-61. 2006
    ..To evaluate the relation between serum thyroid-stimulating hormone (TSH) and lipids...
  80. ncbi Thyroid function is associated with components of the metabolic syndrome in euthyroid subjects
    Annemieke Roos
    Department of Endocrinology, University Medical Center Groningen and University of Groningen, P O Box 30001, 9700 RB Groningen, The Netherlands
    J Clin Endocrinol Metab 92:491-6. 2007
    ..Thyroid disease and the metabolic syndrome are both associated with cardiovascular disease...
  81. ncbi Sorafenib-induced hypothyroidism is associated with increased type 3 deiodination
    Randa M Abdulrahman
    Department of Endocrinology, C4 R, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Endocrinol Metab 95:3758-62. 2010
    ..Decreased serum thyroid hormone levels during tyrosine kinase inhibitors are also observed in athyreotic patients with thyroid carcinoma. We therefore hypothesized that tyrosine kinase inhibitors may influence thyroid hormone metabolism...
  82. ncbi Iodine deficiency and brain development in the first half of pregnancy
    Gabriella Morreale de Escobar
    Instituto de Investigaciones Biomedicas Alberto Sols, CSIC and UAM, Calle Arturo Duperier, 4, 28029 Madrid, Spain
    Public Health Nutr 10:1554-70. 2007
    ....
  83. ncbi Low thyroid function leads to cardiac atrophy with chamber dilatation, impaired myocardial blood flow, loss of arterioles, and severe systolic dysfunction
    Yi da Tang
    Cardiovascular Research Institute, South Dakota Health Research Foundation, University of South Dakota School of Medicine, Sioux Valley Hospitals and Health Systems, Sioux Falls, SD, USA
    Circulation 112:3122-30. 2005
    Although thyroid dysfunction has been linked to heart failure, it is not clear whether hypothyroidism alone can cause heart failure.
  84. ncbi Neuropsychological function and symptoms in subjects with subclinical hypothyroidism and the effect of thyroxine treatment
    Rolf Jorde
    Institute of Clinical Medicine R J, K W, University of Tromsø, 9037 Tromsø, Norway
    J Clin Endocrinol Metab 91:145-53. 2006
    Our objective was to examine the relation between neuropsychological function and subclinical hypothyroidism (SHT), defined as serum TSH of 3.5-10...
  85. ncbi Subclinical hypothyroidism is associated with insulin resistance in rheumatoid arthritis
    Patrick H Dessein
    Department of Rheumatology, Johannesburg Hospital and Milpark Hospital, University of the Witwatersrand, Johannesburg, South Africa
    Thyroid 14:443-6. 2004
    We investigated the prevalence of subclinical hypothyroidism and its association with insulin resistance and other cardiovascular (CV) risk factors in rheumatoid arthritis (RA)...
  86. ncbi Risk factors for cardiovascular disease in patients with subclinical hypothyroidism
    Fusun Toruner
    Department of Endocrinology and Metabolism, Gazi University, Faculty of Medicine, Ankara, Turkey
    Adv Ther 25:430-7. 2008
    The relationship between subclinical hypothyroidism (SCH) and cardiovascular disease is not fully understood...
  87. ncbi The influence of age on the relationship between subclinical hypothyroidism and ischemic heart disease: a metaanalysis
    Salman Razvi
    Department of Endocrinology, Queen Elizabeth Hospital, Gateshead, NE9 6SX, United Kingdom
    J Clin Endocrinol Metab 93:2998-3007. 2008
    Subclinical hypothyroidism (SCH) is a common condition that has been associated with ischemic heart disease (IHD) in some, but not all, studies. This may be due to differences in study design and the characteristics of participants.
  88. ncbi Cerebral blood flow abnormalities induced by transient hypothyroidism after thyroidectomy--analysis by tc-99m-HMPAO and SPM96
    Shigeki Nagamachi
    Department of Radiology, Miyazaki Medical College, Kihara, Japan
    Ann Nucl Med 18:469-77. 2004
    ..study is an investigation of alterations in regional cerebral blood flow (rCBF) distribution in patients with transient hypothyroidism after thyroidectomy. In addition, the effects of thyroxine treatment on rCBF changes were studied.
  89. ncbi Functional study of a novel single deletion in the TITF1/NKX2.1 homeobox gene that produces congenital hypothyroidism and benign chorea but not pulmonary distress
    Christian M Moya
    Biomedical Research Institute Alberto Sols, Spanish National Research Council Autonomous University of Madrid, Madrid, Spain
    J Clin Endocrinol Metab 91:1832-41. 2006
    We studied two sisters with congenital hypothyroidism and choreoathetosis but not respiratory distress.
  90. ncbi Antioxidant status in the serum of persons with intellectual disability and hypothyroidism: a pilot study
    Eli Carmeli
    Department of Physical Therapy, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel
    Res Dev Disabil 29:431-8. 2008
    b>Hypothyroidism (HPO) in humans is widely believed to impair health. The biochemical factors mediating decline in health, however, are poorly elucidated. Pathological consequences of HPO point to a high potential for antioxidant imbalance...
  91. ncbi Lipoprotein alterations, hepatic lipase activity, and insulin sensitivity in subclinical hypothyroidism: response to L-T(4) treatment
    Gabriela Brenta
    Division of Endocrinology and Metabolism, Hospital Francés de Buenos Aires, Buenos Aires, Argentina
    Thyroid 17:453-60. 2007
    Subclinical hypothyroidism (sH) has been associated with atherosclerotic cardiovascular disease even in the absence of hypercholesterolemia.
  92. ncbi Maternal hypothyroidism in early and late gestation: effects on neonatal and obstetric outcome
    Iskandar Idris
    Department of Diabetes and Endocrinology, Nottingham City Hospital, UK
    Clin Endocrinol (Oxf) 63:560-5. 2005
    Maternal hypothyroidism may be associated with a variety of adverse neonatal and obstetric outcomes...
  93. pmc Developmental delays consistent with cochlear hypothyroidism contribute to failure to develop hearing in mice lacking Slc26a4/pendrin expression
    Philine Wangemann
    Anatomy and Physiology Department, Kansas State University, Manhattan, KS 66506, USA
    Am J Physiol Renal Physiol 297:F1435-47. 2009
    ..of the present study was to determine whether developmental delays, possibly mediated by systemic or local hypothyroidism, contribute to the failure to develop hearing in mice lacking Slc26a4 (Slc26a4(-/-))...
  94. ncbi Are the effects of T3 on resting metabolic rate in euthyroid rats entirely caused by T3 itself?
    Maria Moreno
    Dipartimento di Scienze Biologiche ed Ambientali, Universita degli Studi del Sannio, 82100 Benevento, Italy
    Endocrinology 143:504-10. 2002
    ..Because the effects of T3 and 3,5-T2 are additive, in N rats, the two iodothyronines probably cooperate in vivo to determine the total metabolic rate...
  95. ncbi Comparative evaluation of therapy with L-thyroxine versus no treatment in children with idiopathic and mild subclinical hypothyroidism
    Malgorzata Wasniewska
    Department of Pediatrics, University of Messina, Messina, Italy
    Horm Res Paediatr 77:376-81. 2012
    The question of whether children with subclinical hypothyroidism (SH) should be treated or not is controversial due to the lack of studies on outcomes of SH children treated with L-thyroxine (L-T(4)) versus those receiving no therapy.
  96. ncbi Thyroid hormones and their effects: a new perspective
    A J Hulbert
    Metabolic Research Centre and Department of Biological Sciences, University of Wollongong, NSW, Australia
    Biol Rev Camb Philos Soc 75:519-631. 2000
    ..Findings from receptor 'knockout' mice supports an important role for receptors in the development of the thyroid axis. These iodothyronines may be better thought of as 'vitamone'-like molecules than traditional hormonal messengers...
  97. ncbi Serum concentrations of adipocytokines in patients with hyperthyroidism and hypothyroidism before and after control of thyroid function
    Pedro Iglesias
    Department of Endocrinology, Hospital General, Segovia, Spain
    Clin Endocrinol (Oxf) 59:621-9. 2003
    ..The aim of this study was to evaluate the circulating levels of leptin, adiponectin and resistin in patients with thyroid dysfunction before and after normalization of thyroid function with appropriate therapy...
  98. ncbi Timing and magnitude of increases in levothyroxine requirements during pregnancy in women with hypothyroidism
    Erik K Alexander
    Thyroid Section, Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 351:241-9. 2004
    b>Hypothyroidism during pregnancy has been associated with impaired cognitive development and increased fetal mortality. During pregnancy, maternal thyroid hormone requirements increase...
  99. ncbi Phosphodiesterase 8B gene polymorphism is associated with subclinical hypothyroidism in pregnancy
    Beverley M Shields
    Peninsula National Institute for Health Research Clinical Research Facility, Peninsula Medical School, Exeter University, Exeter EX2 5DW, United Kingdom
    J Clin Endocrinol Metab 94:4608-12. 2009
    Maternal subclinical hypothyroidism is associated with a number of adverse outcomes in pregnancy. The Endocrine Society's recent consensus guidelines have recommended treatment with T(4) for this condition in pregnancy...
  100. ncbi Thyroid autoimmunity and hypothyroidism before and during pregnancy
    Kris Poppe
    Academisch Ziekenhuis, Department of Endocrinology, Laarbeeklaan, Brussels
    Hum Reprod Update 9:149-61. 2003
    ..current knowledge and concepts concerning the complex relationships that link thyroid autoimmunity (TAI) and hypothyroidism with female and male infertility, as well as abnormalities occurring during pregnancy, such as pregnancy loss ..
  101. ncbi Thyrotropin suppression by metformin
    Robert A Vigersky
    Endocrinology Service, Walter Reed, Army Medical Center, Washington, DC 20307, USA
    J Clin Endocrinol Metab 91:225-7. 2006
    ..Metformin has been available in the United States for 9 yr and elsewhere for many years, but as of yet there are no reports that the drug modifies thyroid hormone economy...

Research Grants66

  1. Regulation of thyroid hormone levels by central and peripheral pathways
    KRISTEN RACHEL VELLA; Fiscal Year: 2013
    ..aims will be investigated using a combination of knockout mouse models, specialized diets to induce obesity or hypothyroidism, and Designer Receptors Exclusively Activated by Designer Drugs (DREADD) technology...
  2. Flame Retardant and Adverse Perinatal Outcome (FRAPO)
    Morgan R Peltier; Fiscal Year: 2013
    ..Women with hypothyroidism are at increased risk for preterm birth, the foremost problem in modern obstetrics, through an unknown ..
  3. Understanding thyroid hormone regulation of neurogenesis in the cochlea
    Mirna Mustapha; Fiscal Year: 2013
    ..This grant application builds on our observations that congenital secondary hypothyroidism causes profound deafness in Pit1dw mice and thyroid supplementation during pregnancy and early neonatal life ..
  4. Iodine Nutrition and Thyroid Disease During Pregnancy and Lactation
    ANGELA MEI TIN LEUNG; Fiscal Year: 2013
    ..The broad objective of this proposal is to test the hypotheses that: 1) hypothyroidism during pregnancy is associated with premature birth and other adverse obstetric/perinatal outcomes, and 2) ..
  5. ANIMAL MODELS OF HYPERTHYROIDISM
    Sandra M McLachlan; Fiscal Year: 2012
    ..immunization of some A-subunit transgenics depleted of Treg induces thyroid lymphocytic infiltrates, hypothyroidism and murine thyroglobulin and thyroid peroxidase antibodies. Mice without infiltrates lack these antibodies...
  6. Lab-on-a-chip for Neonatal Hyperbilirubinemia Screening
    Vijay Srinivasan; Fiscal Year: 2012
    ..Underlying causes such as glucose-6-phosphate dehydrogenase (G6PD) deficiency and congenital hypothyroidism (CH) should be strongly considered...
  7. Cardiometabolic Risk Factors and Obesity in Adolescents with Down Syndrome
    Sheela Natesh Magge; Fiscal Year: 2013
    ..risk factors, and quality of life (QOL) in pre-adolescents and adolescents with Down syndrome and subclinical hypothyroidism. Secondary Aim) To examine the relationship between obesity, lifestyle (physical activity, nutrition), body ..
  8. Integration of Signaling Pathways Regulating Chondrocyte Differentiation
    Sherrill L Adams; Fiscal Year: 2010
    ..g. hypothyroidism, which blocks T3 signaling) prevents differentiation, resulting in shortened bones...
  9. Cerebrospinal fluid proteome mediated signaling in the developing CNS
    Maria Lehtinen; Fiscal Year: 2013
    ..Bruce McEwen's laboratory, I investigated how hypothyroidism altered signaling molecules in the brain...
  10. Cerebrospinal fluid proteome mediated signaling in the developing CNS
    Maria Lehtinen; Fiscal Year: 2011
    ..Bruce McEwen's laboratory, I investigated how hypothyroidism altered signaling molecules in the brain...
  11. Brain aromatase availability in steroid users: PET studies with [11C]vorozole
    Thomas B Hildebrandt; Fiscal Year: 2013
    ..Medical consequences may include increased risk for cardiac events, liver toxicity, skeletal changes, and hypothyroidism, and overall higher mortality and morbidity...
  12. TSHR and thyrocyte development
    Reigh Yi Lin; Fiscal Year: 2013
    ..The hypothyroid mice display severe congenital hypothyroidism and thyroid hyperplasia and provide an opportunity to explore the pathophysiological manifestations of this ..
  13. Colorectal Cancer Prevention Through Thyroid Hormone Targets
    ADAM ROBERT BROWN; Fiscal Year: 2013
    ..Other studies have shown that many elderly patients exhibit sub-clinical hypothyroidism and decreased thyroid hormone sensitivity...
  14. MIF-Thyroxine Interactions in the Pathogenesis of Pulmonary Arterial Hypertension
    Edmund J Miller; Fiscal Year: 2013
    ..during the development of PAH alters the normal plasma MIF-free T4 ratio and underlies the high prevalence of hypothyroidism that has been reported in patients with pulmonary hypertension...
  15. The Down Syndrome Growing Up Study
    Babette S Zemel; Fiscal Year: 2012
    ..g., hypothyroidism, hydrocephalus) in a timely manner...
  16. Is thyroxine more than a prohormone?
    Valerie Anne Galton; Fiscal Year: 2013
    ..Analogous impairments result from perinatal hypothyroidism in rodents...
  17. Low Thyroid function and myocardial infarction
    Anthony Martin Gerdes; Fiscal Year: 2013
    ..MI-related mortality increases as THs decline and rT3 levels increase. Additionally, hypothyroidism alone can lead to dilated heart failure while promoting a maladaptive change in myocyte shape and increased ..
  18. THYROCYTE PROTEIN TRANSPORT TO THE CELL SURFACE
    Peter Arvan; Fiscal Year: 2012
    ..in its intracellular transport relate to patients and animal models with thyroid disease including congenital hypothyroidism with and without goiter...
  19. CARDIAC CONTRACTILE KINETICS
    Michael Regnier; Fiscal Year: 2009
    ..the leading cause of death in the United States and pathologies such as diabetes, hypertrophic cardiomyopathy, hypothyroidism and heart failure, as well as ischemia/reperfusion injury, involve alterations in myocardial contractile and ..
  20. Reductive Dehalogenation in Mammals by Iodotyrosine Deiodinase
    Steven E Rokita; Fiscal Year: 2012
    ..The process by which we recycle iodide from byproducts formed during hormone biosynthesis will be investigated and is crucial to understand the basis for certain congenital defects leading to hypothyroidism.
  21. Thyroid hormone regulation of vasculature in adult myocardium
    Anthony Martin Gerdes; Fiscal Year: 2010
    ..After demonstrating that hypothyroidism induced by either thyroidectomy or propylthioruacil (PTU) leads to a dramatic loss of myocardial arterioles ..
  22. Translational Recoding of UGA as Selenocysteine in Selenoprotein Synthesis
    Donna M Driscoll; Fiscal Year: 2013
    ..domain in SBP2 and showed that a naturally occurring point mutation in this domain, which is associated with hypothyroidism in humans, alters the SECIS-binding activity of the protein and selectively affects the expression of a subset ..
  23. Subclinical thyroid dysfunction in the elderly
    Anne R Cappola; Fiscal Year: 2013
    ..cardiovascular, musculoskeletal, and neurocognitive outcomes, whereas those with persistent subclinical hypothyroidism are not...
  24. Role of Neurogranin in Hippocampal Synaptic Plasticity
    Nashaat Z Gerges; Fiscal Year: 2013
    ..has been implicated in several neurological disorders, such as Alzheimer's disease, schizophrenia, aging, hypothyroidism and stress, and its levels correlate with memory performance...
  25. Regulators of Calcium Signaling
    JOHN ANTHONY PUTKEY; Fiscal Year: 2013
    ..In addition, Ng levels are down regulated in hypothyroidism, Alzheimer disease and schizophrenic patients...
  26. Corepressor Regulation of Nuclear Receptor Action
    Anthony N Hollenberg; Fiscal Year: 2013
    ..In the second Aim, we will focus on exploring the role of NCoR in both congenital hypothyroidism and resistance to thyroid hormone...
  27. THYROID HORMONE AND THE GUT
    Richard A Hodin; Fiscal Year: 2010
    ..be applied in the contexts of two susceptibility conditions in which IAP expression is lost, starvation and hypothyroidism. These studies in IAP KO and transgenic mice will allow us to determine the role that IAP plays in the gut ..
  28. Hyopthyroidism Treatment in Aging and Thyroid Cancer
    Offie P Soldin; Fiscal Year: 2013
    ..b>Hypothyroidism (HT) found in 4...
  29. Subclinical Hypothyroidism: Mood, Cognition and the effect of L-thyroxine treatme
    Robert A Stern; Fiscal Year: 2012
    Abstract Subclinical hypothyroidism is a biochemical diagnosis characterized by elevated thyrotropin (TSH) levels with normal circulating thyroxine (T4) and triiodothyronine (T3) levels...
  30. Risk Factors and Sequelae of Thyroid Disease in Patients with Renal Dysfunction
    CONNIE MEEYOUNG RHEE; Fiscal Year: 2012
    ..There is uncertainty as to whether, and in which direction, hyper- and hypothyroidism may influence mortality in the end-stage renal disease population based on limited data, and there has been no ..
  31. Neurocognitive and Metabolic Effects of Mild Hypothyroidism
    Mary H Samuels; Fiscal Year: 2012
    b>Hypothyroidism is common, affecting 3% of the U.S. population, and up to 20% of older women...
  32. Regulation of lipoprotein lipase in adipocytes
    Philip A Kern; Fiscal Year: 2011
    ..Aim 2. Is the increase in LPL translation from hypothyroidism due to changes in AKAP expression? Aim 3...
  33. 2013 MECHANISMS OF MEMBRANE TRANSPORT GRC
    Nancy Carrasco; Fiscal Year: 2013
    ..of a host of vital molecules, but also for the development of new therapeutic agents and approaches to a wide variety of diseases, including hypertension, depression, hypothyroidism, malabsorption syndromes, and cystic fibrosis.
  34. Planning a Multi-center Trial of Subclinical Hypothyroidism in Older Adults
    Douglas C Bauer; Fiscal Year: 2010
    ..thyrotropin (TSH) and corresponding low thyroid hormone levels, while the much more common entity, subclinical hypothyroidism (SCH), is defined as an elevated TSH but normal thyroid hormone levels...
  35. Data Coord. Center - NICHD Cooperative Multicenter Maternal Fetal Medicine Units
    ELIZABETH ANN THOM; Fiscal Year: 2013
    ..of obstetrical safety and the management of pregnant women with potential risk factors such as subclinical hypothyroidism. The GeorgeWashington UniversityBiostatistics Center proposes to continue to serve as the data coordinating ..
  36. Nutritional and Hormonal Pathways for Reduction of ApoB-lipoproteins
    Li Shin Huang; Fiscal Year: 2013
    ..of T2 and T3 require these gene products to reduce cholesterol or for increased cholesterol in the setting of hypothyroidism. The significance of the experiments is that our studies will define a non-LDL receptor dependent process for ..
  37. Direct analysis of perchlorate and iodide in human tissues by isotachophoresis-zo
    Vladislav Dolnik; Fiscal Year: 2012
    ..of health effect, perchlorate competes with iodide for the intake by mammalian thyroid gland and can cause hypothyroidism. Monitoring perchlorate level in human body fluids is therefore of outmost importance...
  38. NOVEL TECHNOLOGIES IN NEWBORN SCREENING
    STEVEN DOBROWOLSKI PHD; Fiscal Year: 2010
    ..xMAP assays by applying multiplex immunoassay techniques to test for the following conditions: congenital hypothyroidism, congenital adrenal hyperplasia. cystic fibrosis, Krabbe disease and other leukodystrophies...
  39. NOVEL TECHNOLOGIES IN NEWBORN SCREENING
    STEVEN DOBROWOLSKI PHD; Fiscal Year: 2011
    ..xMAP assays by applying multiplex immunoassay techniques to test for the following conditions: congenital hypothyroidism, congenital adrenal hyperplasia. cystic fibrosis, Krabbe disease and other leukodystrophies...
  40. Corepressor Regulation of Nuclear Receptor Action
    Anthony Hollenberg; Fiscal Year: 2009
    ..In the second Aim, we will focus on exploring the role of NCoR in both congenital hypothyroidism and resistance to thyroid hormone...
  41. MOLECULAR BASIS FOR ETHANOL-INDUCED HYPOTHYROIDISM
    Robert Zoeller; Fiscal Year: 1993
    The long term objectives of this research are to understand the molecular basis of ethanol-induced hypothyroidism, and to ultimately utilize this understanding to clarify the effects of ethanol on thermoregulatory function...
  42. MECHANISM OF TRH EFFECTS IN FETAL LUNG DEVELOPMENT
    UDAY DEVASKAR; Fiscal Year: 1999
    ..To investigate these possibilities, we will use the HYT/HYT mouse where primary hypothyroidism occurs due to a mutation (ProyieldsLeu,a.a...
  43. Thyroidal Macrophages in Autoimmune Hypothyroidism and Hurthle Cells
    Patrizio Caturegli; Fiscal Year: 2010
    ..thyroid architecture, mononuclear infiltration, oncocytic changes of the thyrocytes, and long-lasting hypothyroidism. The mice have contributed to discover that the thyroid cells affected by autoimmunity express elevated levels ..
  44. NEWBORN SCREENING TRANSLATIONAL RESEARCH NETWORK COORD CTR
    MELISSA FORBURGER; Fiscal Year: 2012
    ..mUltiplex microsphere sets with conjugated antibodies for specific analyte detection to screen for congenital hypothyroidism, cystic fibrosis, congenital adrenal hyperplasia, and the leukodystrophies Krabbe and Pompe disease...
  45. NEWBORN SCREENING TRANSLATIONAL RESEARCH NETWORK COORD CTR
    MELISSA T FORBURGER; Fiscal Year: 2011
    ..mUltiplex microsphere sets with conjugated antibodies for specific analyte detection to screen for congenital hypothyroidism, cystic fibrosis, congenital adrenal hyperplasia, and the leukodystrophies Krabbe and Pompe disease...
  46. NOVEL TECHNOLOGIES IN NEWBORN SCREENING
    Kenneth Pass; Fiscal Year: 2010
    ..mUltiplex microsphere sets with conjugated antibodies for specific analyte detection to screen for congenital hypothyroidism, cystic fibrosis, congenital adrenal hyperplasia, and the leukodystrophies Krabbe and Pompe disease...
  47. NEWBORN SCREEING TRANSLATIONAL RESEARCH NETWORK COORD CTR
    MELISSA T FORBURGER; Fiscal Year: 2010
    ..mUltiplex microsphere sets with conjugated antibodies for specific analyte detection to screen for congenital hypothyroidism, cystic fibrosis, congenital adrenal hyperplasia, and the leukodystrophies Krabbe and Pompe disease...
  48. Endocrine Disruption in Pregnant Women:Thyroid Disruption and Infant Development
    Ronald Wapner; Fiscal Year: 2011
    ..Recent data suggests that even in asymptomatic women with subclinical hypothyroidism, intelligence of their offspring is affected...
  49. HORMONAL REGULATION OF ENERGY METABOLISM
    Tarun Patel; Fiscal Year: 1993
    ..g. hypothyroidism) suggest that atriopeptin may participate in the regulation of hepatic gluconeogenesis...
  50. Midcareer Investigator Award in Patient-Oriented Research in Aging
    Anne R Cappola; Fiscal Year: 2013
    ..goal of this proposal is to investigate the physiologi underpinnings and clinical ramifications of subclinical hypothyroidism in the elderly...
  51. CNS DEVELOPMENT UNDER HYPERGRAVITY : MODULATION BY TH?
    ELIZABETH SAJDEL SULKOWSKA; Fiscal Year: 2004
    ..size and structure observed at 15G will become more pronounced at higher gravitational loading; (2) the mild hypothyroidism observed at 1.5 G will become more severe at higher gravitational loading...
  52. Lab-on-a-chip for Neonatal Hyperbilirubinemia Screening
    Vijay Srinivasan; Fiscal Year: 2009
    ..committee also identified the need for screening for hereditary causes such as G6PD deficiency and congenital hypothyroidism, which if present can change the treatment completely...
  53. COREPRESSORS AND NEGATIVE REGULATION BY THYROID HORMONE
    Ronald Cohen; Fiscal Year: 2002
    ..underlying thyroid hormone resistance and thyroid hormone action, which will shed light on the basis of human hypothyroidism and hyperthyroidism...
  54. Eunice Kennedy Shriver NICHD Maternal Fetal Medicine Units Network (U10)
    Brian M Casey; Fiscal Year: 2013
    ..5 year cycle, our center led the implementation of the randomized trial of thyroxine therapy for subclinical hypothyroidism or hypothyroxinemia diagnosed during pregnancy (TSH) study which successfully screened more than 97,000 women ..
  55. SIMPLIFIED POPULATION SCREENING FOR ADULT HYPOTHYROIDISM
    Edwin Naylor; Fiscal Year: 2000
    ..from the following three populations who are at high risk for the development of autoimmune thyroiditis and hypothyroidism: (a) An elderly population currently Living in Nursing and Personal Care Homes will be screened annually for ..
  56. Environmental Lead, Thyroid Function & Neurodevelopment
    Pam Factor Litvak; Fiscal Year: 2003
    ..Congenital hypothyroidism and transient hypothyroidism of prematurity are associated with deficits in cognition during early life...
  57. Mentored Patient-Oriented Research Career Development Award
    Jacqueline Jonklaas; Fiscal Year: 2006
    ..of this project is to determine what combination of thyroid hormones provides optimum replacement therapy for hypothyroidism. There are two circulating thyroid hormones, thyroxine and triiodothyronine, and standard thyroid hormone ..
  58. A Model Statewide Trial to Detect and Treat Maternal Hypothyroidism in Pregnancy
    James Haddow; Fiscal Year: 2009
    ..community-based trial in Rhode Island (RI), aimed at avoiding or minimizing morbidity from overt maternal hypothyroidism by systematic detection and treatment, beginning at the 1st prenatal visit...
  59. THYROID HORMONE, EPILEPSY, AND CNS MATURATION
    SIENYAO CHOW; Fiscal Year: 1992
    ..increase in activity at 3 and 12 postnatal days, responses that are attenuated by methimazole-induced hypothyroidism. These changes increase susceptibility to seizures...
  60. EXPERIMENTAL AUTOIMMUNE GRAVES' DISEASE
    Bellur Prabhakar; Fiscal Year: 2003
    ..either activate thyroid gland causing hyperthyroidism or block TSH mediated activation of thyroid and cause hypothyroidism. Until several years ago, it was not possible to develop an animal mode due to the unavailability of large ..
  61. Dry-reagent methods for detection of iodine in urine
    GEORGE PLUM; Fiscal Year: 2009
    ..still live under the threat of IDD complications that include: congenital myxedema (cretinism), brain damage, hypothyroidism and goiter...
  62. NEW ENGLAND HYPOTHYROIDISM COLLABORATIVE FOLLOW-UP STUDY
    Marvin Mitchell; Fiscal Year: 1993
    The objective of the proposed study is to complete the follow-up of children with hypothyroidism diagnosed as the result of the neonatal screening program in New England from January 1, 1976 through December 31, 1980...
  63. THYROID HORMONE ACTION IN NEUROGENESIS
    Richard Maas; Fiscal Year: 2001
    Perinatal deficiency of thyroid hormone (TH) or hypothyroidism results in abnormal development of the central nervous system, typified by poor neurite growth and synaptogenesis in the cerebellum...
  64. Interferon gamma in autoimmune thyroiditis & thyroid function
    Patrizio Caturegli; Fiscal Year: 2007
    ..mice that express IFNg specifically in the thyroid gland, and shown that IFNgamma a) directly induces primary hypothyroidism with decreased NIS expression; b) induces Hurthle cells-like and increase thyroidal fat; c) protects from ..