nodular goiter

Summary

Summary: An enlarged THYROID GLAND containing multiple nodules (THYROID NODULE), usually resulting from recurrent thyroid HYPERPLASIA and involution over many years to produce the irregular enlargement. Multinodular goiters may be nontoxic or may induce THYROTOXICOSIS.

Top Publications

  1. ncbi L-thyroxine-treated patients with nodular goiter have lower serum TSH and lower frequency of papillary thyroid cancer: results of a cross-sectional study on 27 914 patients
    E Fiore
    Department of Endocrinology, University of Pisa, Via Paradisa 2, 56100 Pisa, Italy
    Endocr Relat Cancer 17:231-9. 2010
  2. ncbi Iodine-131 given for therapeutic purposes modulates differently interferon-gamma-inducible alpha-chemokine CXCL10 serum levels in patients with active Graves' disease or toxic nodular goiter
    Alessandro Antonelli
    Metabolism Unit, Department of Medicine, Regional Center of Nuclear Medicine, University of Pisa Medical School, Via Roma, 67, I 56100 Pisa, Italy
    J Clin Endocrinol Metab 92:1485-90. 2007
  3. ncbi Evaluation of routine basal serum calcitonin measurement for early diagnosis of medullary thyroid carcinoma in seven hundred seventy-three patients with nodular goiter
    A G Ozgen
    Endocrinology Department, Bornova Izmir, Turkey
    Thyroid 9:579-82. 1999
  4. ncbi The occurrence of hypothyroidism following radioactive iodine treatment of toxic nodular goiter is related to the TSH level
    H I Adamali
    Department of Endocrinology and Diabetes Mellitus, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    Ir J Med Sci 176:199-203. 2007
  5. ncbi Current treatment of nodular goiter with hyperthyroidism (Plummer's disease): surgery versus radioiodine
    Ajaipal S Kang
    Division of Gastroenterologic and General Surgery, Mayo Clinic and Mayo Foundation, 200 2nd Street SW, Rochester, MN 55905, USA
    Surgery 132:916-23; discussion 923. 2002
  6. ncbi Exogenous subclinical hyperthyroidism impairs endothelial function in nodular goiter patients
    Dilek Gogas Yavuz
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Marmara University Medical School, Istanbul, Turkey
    Thyroid 18:395-400. 2008
  7. ncbi Risk factors for recurrent nodular goiter after thyroidectomy for benign disease: case-control study of 244 patients
    Helene Gibelin
    Department of Endocrine Surgery, Jean Bernard Hospital, 86000 Poitiers, France
    World J Surg 28:1079-82. 2004
  8. ncbi Differential expression of miRNAs in papillary thyroid carcinoma compared to multinodular goiter using formalin fixed paraffin embedded tissues
    Michael T Tetzlaff
    Department of Pathology and Laboratory Medicine, Hospital for the University of Pennsylvania, 3400 Spruce Street, 7 Founders Pavilion, Philadelphia, PA 19040, USA
    Endocr Pathol 18:163-73. 2007
  9. ncbi Recombinant human thyrotropin markedly changes the 131I kinetics during 131I therapy of patients with nodular goiter: an evaluation by a randomized double-blinded trial
    Viveque Egsgaard Nielsen
    Department of Endocrinology and Metabolism, Odense University Hospital, DK 5000 Odense C, Denmark
    J Clin Endocrinol Metab 90:79-83. 2005
  10. ncbi Management of simple nodular goiter: current status and future perspectives
    Laszlo Hegedus
    Department of Endocrinology and Metabolism, Odense University Hospital, DK 5000 Odense C, Denmark
    Endocr Rev 24:102-32. 2003

Research Grants

Detail Information

Publications221 found, 100 shown here

  1. ncbi L-thyroxine-treated patients with nodular goiter have lower serum TSH and lower frequency of papillary thyroid cancer: results of a cross-sectional study on 27 914 patients
    E Fiore
    Department of Endocrinology, University of Pisa, Via Paradisa 2, 56100 Pisa, Italy
    Endocr Relat Cancer 17:231-9. 2010
    ..and the development of thyroid autonomy by reducing TSH levels decreases the frequency of PTC in patients with nodular goiter. Our aim was to investigate the effect of L-thyroxine (LT(4)) on the frequency of PTC diagnosed by cytology in ..
  2. ncbi Iodine-131 given for therapeutic purposes modulates differently interferon-gamma-inducible alpha-chemokine CXCL10 serum levels in patients with active Graves' disease or toxic nodular goiter
    Alessandro Antonelli
    Metabolism Unit, Department of Medicine, Regional Center of Nuclear Medicine, University of Pisa Medical School, Via Roma, 67, I 56100 Pisa, Italy
    J Clin Endocrinol Metab 92:1485-90. 2007
    ..of the present study was to measure the serum CXCL10 levels in 20 patients with GD and 10 patients with toxic nodular goiter (TNG) before and 6 months after 131I treatment, when patients had achieved euthyroidism...
  3. ncbi Evaluation of routine basal serum calcitonin measurement for early diagnosis of medullary thyroid carcinoma in seven hundred seventy-three patients with nodular goiter
    A G Ozgen
    Endocrinology Department, Bornova Izmir, Turkey
    Thyroid 9:579-82. 1999
    ..and to determine whether basal serum calcitonin measurements should be a part of the routine evaluation of a nodular goiter. Basal serum calcitonin levels were obtained from 75 patients (female:male 57:18, mean age 42...
  4. ncbi The occurrence of hypothyroidism following radioactive iodine treatment of toxic nodular goiter is related to the TSH level
    H I Adamali
    Department of Endocrinology and Diabetes Mellitus, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    Ir J Med Sci 176:199-203. 2007
    ..Strategies to increase frequency of euthyroidism following radioactive (RAI) treatment of hyperthyroidism are required...
  5. ncbi Current treatment of nodular goiter with hyperthyroidism (Plummer's disease): surgery versus radioiodine
    Ajaipal S Kang
    Division of Gastroenterologic and General Surgery, Mayo Clinic and Mayo Foundation, 200 2nd Street SW, Rochester, MN 55905, USA
    Surgery 132:916-23; discussion 923. 2002
    First described 9 decades ago by H. S. Plummer, thyroidectomy and radioiodine remain the 2 therapeutic modalities for toxic nodular goiter. The aim of this study was to determine its optimal treatment.
  6. ncbi Exogenous subclinical hyperthyroidism impairs endothelial function in nodular goiter patients
    Dilek Gogas Yavuz
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Marmara University Medical School, Istanbul, Turkey
    Thyroid 18:395-400. 2008
    ..The aim of this study was to evaluate the effect of levothyroxine (LT4) suppression on endothelial function and insulin sensitivity in euthyroid nodular goiter patients.
  7. ncbi Risk factors for recurrent nodular goiter after thyroidectomy for benign disease: case-control study of 244 patients
    Helene Gibelin
    Department of Endocrine Surgery, Jean Bernard Hospital, 86000 Poitiers, France
    World J Surg 28:1079-82. 2004
    Surgery for recurrent nodular goiter is associated with a significant risk of parathyroid and recurrent laryngeal nerve (RLN) morbidity. Total thyroidectomy for benign disease is assessed...
  8. ncbi Differential expression of miRNAs in papillary thyroid carcinoma compared to multinodular goiter using formalin fixed paraffin embedded tissues
    Michael T Tetzlaff
    Department of Pathology and Laboratory Medicine, Hospital for the University of Pennsylvania, 3400 Spruce Street, 7 Founders Pavilion, Philadelphia, PA 19040, USA
    Endocr Pathol 18:163-73. 2007
    ..The ability to utilize FFPE tissue in the molecular characterization of human malignancy will unlock a rich resource for future cancer studies...
  9. ncbi Recombinant human thyrotropin markedly changes the 131I kinetics during 131I therapy of patients with nodular goiter: an evaluation by a randomized double-blinded trial
    Viveque Egsgaard Nielsen
    Department of Endocrinology and Metabolism, Odense University Hospital, DK 5000 Odense C, Denmark
    J Clin Endocrinol Metab 90:79-83. 2005
    ..3 mg recombinant human (rh)TSH (n = 35) or placebo (n = 28) given 24 h before (131)I therapy in patients with nodular goiter (median volume, 69 ml; range, 20-440 ml)...
  10. ncbi Management of simple nodular goiter: current status and future perspectives
    Laszlo Hegedus
    Department of Endocrinology and Metabolism, Odense University Hospital, DK 5000 Odense C, Denmark
    Endocr Rev 24:102-32. 2003
    The simple nodular goiter, the etiology of which is multifactorial, encompasses the spectrum from the incidental asymptomatic small solitary nodule to the large intrathoracic goiter, causing pressure symptoms as well as cosmetic ..
  11. ncbi Value of repeated fine needle aspiration cytology in patients with nodular goiter
    Edelmiro Menéndez Torre
    Unidad de Patología Tiroidea, Hospital de Navarra y Hospital Virgen del Camino, Servicio Navarro de Salud, Pamplona, Spain
    Acta Cytol 51:850-2. 2007
    ..To assess the value of reaspiration cytology in benign nodular thyroid disease...
  12. ncbi Multinucleated giant cells in fine needle aspirates. Can they help differentiate papillary thyroid cancer from benign nodular goiter?
    Pei Ling Tsou
    Department of Internal Medicine, College of Medicine, National Taiwan University, National Taiwan University Hospital, Taipei, Taiwan
    Acta Cytol 46:823-7. 2002
    To determine whether multinucleated giant cells (MGCs) in fine needle aspirates can help differentiate papillary thyroid carcinoma (PTC) from benign nodular goiter (BNG).
  13. ncbi Ultrasound-guided fine-needle aspiration biopsy and ultrasonographic features of infracentimetric nodules in patients with nodular goiter: correlation with pathological findings
    Mustafa Sahin
    Department of Endocrinology and Metabolic Disease, Baskent University, Ankara, Turkey
    Endocr Pathol 17:67-74. 2006
    ..The cytopathological results of 472 US-FNABs from 207 nodular goiter patients (170 women, 37 men; mean age, 51.5 +/- 13...
  14. ncbi Ultrasound-guided laser thermal ablation in the treatment of autonomous hyperfunctioning thyroid nodules and compressive nontoxic nodular goiter
    Stefano Spiezia
    Department of Surgery, Ultrasound Guided and Neck Pathologies Surgery Unit, S Maria del Popolo degli Incurabili Hospital ASL NA1, Naples, Italy
    Thyroid 13:941-7. 2003
    ..Percutaneous laser thermal ablation (LTA) has been applied in several tumors. In this study we evaluated the safety and long-term efficacy of LTA in the treatment of benign thyroid nodules...
  15. ncbi Recombinant human thyrotropin-stimulated radioiodine therapy of nodular goiter allows major reduction of the radiation burden with retained efficacy
    Søren Fast
    Department of Endocrinology and Metabolism, Odense University Hospital, DK 5000 Odense C, Denmark
    J Clin Endocrinol Metab 95:3719-25. 2010
    ..Observations indicate that rhTSH has a preconditioning effect beyond increasing thyroid (131)I uptake. We test the hypothesis that an equivalent GVR might be obtained by an absorbed thyroid dose well below what has been used previously...
  16. ncbi Spontaneous rupture with pseudoaneurysm formation in a nodular goiter presenting as a large neck mass
    Chia Che Chang
    Department of Emergency Medicine, Lotung Poh Ai Hospital, Lotung, Ilan, Taiwan
    J Clin Ultrasound 35:518-20. 2007
    ..We report a case of nodular goiter in which spontaneous rupture with active bleeding developed suddenly, presenting as a large neck mass with ..
  17. ncbi [The LISA trial-a- randomized, double-blind, placebo-controlled four-arm study of 1,000 patients with nodular goiter in Germany. Study Design and first results of feasibility]
    Martin Grussendorf
    Endokrinologie und Diabetologie im Zentrum, Stuttgart
    Med Klin (Munich) 100:542-6. 2005
    Although levothyroxine is the mostly prescribed medicament in Germany, its therapeutic effectiveness in nodular goiter was never studied in a randomized, double-blind trial with sufficient power...
  18. ncbi Serum hepatocyte growth factor is increased in Hashimoto's thyroiditis whether or not it is associated with nodular goiter as compared with healthy non-goitrous individuals
    R M Ruggeri
    Unit of Endocrinology, Clinical Experimental Department of Medicine and Pharmacology, University of Messina, Messina, Italy
    J Endocrinol Invest 32:465-9. 2009
    ..Some growth factors and cytokines are known to cooperate with TSH in thyroid nodular growth, but few data are available on their circulating levels in Hashimoto's thyroiditis (HT)...
  19. ncbi Subclinical hyperthyroidism in cats: a spontaneous model of subclinical toxic nodular goiter in humans?
    Jennifer Wakeling
    Department of Veterinary Clinical Sciences, Royal Veterinary College, London, United Kingdom
    Thyroid 17:1201-9. 2007
    ..in cats, caused by nodular hyperplasia or adenomas, is clinically and histologically similar to toxic nodular goiter in humans...
  20. ncbi Video-assisted surgery of the thyroid diseases
    M Ruggieri
    Department of Surgical Sciences and Applied Medical Technologies Francisco Durante, University of Rome La Sapienza, Rome, Italy
    Eur Rev Med Pharmacol Sci 7:91-6. 2003
    ..The patients were considered eligible for MIVA hemithyroidectomy and thyroidectomy on the basis of some criteria...
  21. ncbi Effects on bone mineral density by treatment of benign nodular goiter with mildly suppressive doses of L-thyroxine in a cohort women study
    M Appetecchia
    Endocrinology Unit, Regina Elena Cancer Institute, Rome, Italy
    Horm Res 64:293-8. 2005
    ..inhibiting serum thyroid-stimulating hormone (TSH) doses on bone mineral density (BMD) and biochemical bone remodeling markers in a cohort of women with benign nodular goiter, and to verify the efficacy of the treatment on nodule size.
  22. ncbi Dosimetry of radioiodine therapy in patients with nodular goiter after pretreatment with a single, low dose of recombinant human thyroid-stimulating hormone
    Willy Anne Nieuwlaat
    Department of Nuclear Medicine, Catharina Hospital, Eindhoven, The Netherlands
    J Nucl Med 45:626-33. 2004
    ..24-h RAIU and causes a more homogeneous distribution of radioiodine on thyroid scintigrams of patients with nodular goiter. Pretreatment with rhTSH allows the therapeutic dose of (131)I to be reduced by 50%-60% without compromising ..
  23. ncbi Serum levels of cytokines in children and adolescents with Graves' disease and non-toxic nodular goiter
    A Bossowski
    2nd Department of Children s Diseases, Medical Academy of Białystok, Poland
    J Pediatr Endocrinol Metab 14:741-7. 2001
    ..8 years), in patients with nontoxic nodular goiter (NTNG) (n=36, mean age 15.6 years) and in a group of healthy controls (n=20, mean age 14.5 years)...
  24. ncbi Retrospective analysis of the association of nodular goiter with primary and secondary hyperparathyroidism
    S Baldari
    Nuclear Medicine Service, Di Venere Hospital, Bari, Italy
    Eur J Endocrinol 145:429-34. 2001
    ..5%), but only 92/246 patients in group B (38.2%) had thyroid disorders (notably nodular goiter) associated with HPT (P=0.0035)...
  25. ncbi Calcitonin measurement to detect medullary thyroid carcinoma in nodular goiter: German evidence-based consensus recommendation
    W Karges
    Department of Internal Medicine, University of Ulm, Ulm, Germany
    Exp Clin Endocrinol Diabetes 112:52-8. 2004
    ..evidence, we propose multidisciplinary consensus recommendations for the clinical use of CT in patients with nodular goiter. To exclude MTC, serum CT should be determined in patients with nodular thyroid disease, using a two-site CT ..
  26. ncbi Stimulation with 0.3-mg recombinant human thyrotropin prior to iodine 131 therapy to improve the size reduction of benign nontoxic nodular goiter: a prospective randomized double-blind trial
    Viveque Egsgaard Nielsen
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Arch Intern Med 166:1476-82. 2006
    ..Use of recombinant human thyrotropin increases the thyroid radioiodine (iodine 131 [(131)I]) uptake and may have a role in the context of (131)I therapy of benign goiter...
  27. ncbi Pretreatment with a single, low dose of recombinant human thyrotropin allows dose reduction of radioiodine therapy in patients with nodular goiter
    Willy Anne Nieuwlaat
    Department of Nuclear Medicine, Catharina Hospital, 5602 ZA Eindhoven, The Netherlands
    J Clin Endocrinol Metab 88:3121-9. 2003
    In patients with nodular goiter, radioiodine ((131)I) therapy results in a mean reduction in thyroid volume (TV) of approximately 40% after 1 yr...
  28. ncbi Transient goiter enlargement after administration of 0.3 mg of recombinant human thyrotropin in patients with benign nontoxic nodular goiter: a randomized, double-blind, crossover trial
    Viveque Egsgaard Nielsen
    Department of Endocrinology and Metabolism, Odense University Hospital, DK 5000 Odense C, Denmark
    J Clin Endocrinol Metab 91:1317-22. 2006
    ..01 to 0.9 mg, has been used to augment the effect of radioiodine ((131)I) therapy in patients with a benign nontoxic nodular goiter. Transient thyroid enlargement and thyrotoxicosis may be seen following (131)I therapy.
  29. ncbi Smoking as a risk factor for Graves' disease, toxic nodular goiter, and autoimmune hypothyroidism
    Peter Vestergaard
    The Osteoporosis Clinic, Aarhus Amtssygehus, Aarhus University Hospital, Denmark
    Thyroid 12:69-75. 2002
    ..5, 95% confidence interval [CI]: 1.8-3.5), toxic nodular goiter (OR = 1.7, 95% CI: 1.1-2.5), and autoimmune hypothyroidism (OR = 1.5, 95% CI: 1.1-2...
  30. ncbi Comparison between echo-color Doppler sonography features and angioarchitecture of thyroid nodules
    Maria P Foschini
    Department of Anatomic Pathology, University of Bologna Ospedale Bellaria, Italy
    Int J Surg Pathol 15:135-42. 2007
    ..This architectural pattern is not seen in benign nodules or in papillary carcinomas. Comparison with histology suggests that echo-color Doppler images can visualize vessels showing a muscular wall...
  31. ncbi [Management of subclinical hyperthyroidism]
    Juan Carlos Galofré
    Departamento de Endocrinología y Nutrición, Clinica Universitaria, Facultad de Medicina, Universidad de Navarra, Espana
    Rev Med Univ Navarra 51:18-22. 2007
    ..In its management, the same treatments are used as in overt hyperthyroidism...
  32. ncbi Diagnosis and surgical management for retrosternal thyroid mass
    Yushang Cui
    Department of Thoracic Surgery, PUMC Hospital, CAMS and PUMC, Beijing 100730
    Chin Med Sci J 17:173-7. 2002
    ..To understand the clinical manifestations, diagnostic methods, surgical management and prognosis of retrosternal thyroid masses in various pathological types...
  33. ncbi Determination of remnant thyroid volume: comparison of ultrasonography, radioactive iodine uptake and serum thyroid-stimulating hormone level
    Y Erbil
    Department of General Surgery, Medical Faculty, Istanbul University, Turkey
    J Laryngol Otol 122:615-22. 2008
    ..We aimed to evaluate the accuracy of ultrasonography, radioactive iodine uptake and serum thyroid-stimulating hormone level in predicting the volume of remnant thyroid gland...
  34. ncbi [How to treat benign thyroid gland nodules]
    Th Siegmund
    Krankenhaus Munchen Bogenhausen
    MMW Fortschr Med 146:24-7. 2004
    ..Depending on the individual situation of the patient, the therapeutic option of choice is surgical operation or treatment with iodine-31 therapy. Medical treatment of nodular goiter is currently still controversial.
  35. ncbi [Video-assisted thyroidectomy with minimally invasive central cervicotomy: initial experience in an endocrine surgery division]
    Antonio Ambrosi
    UO di Chirurgia Generale, Dipartimento di Scienze Chirurgiche, Universita degli Studi di Foggia
    Chir Ital 58:549-56. 2006
    ..In our experience the clinical impact was limited as a result of the small percentage of patients fulfilling the strict inclusion criteria...
  36. ncbi Importance of thyroglobulin levels for diagnosis and monitoring of follicular thyroid carcinoma in an adolescent with severe iodine deficiency
    Zeynep Siklar
    Department of Pediatric Endocrinology, Ankara University Medical School, Ankara, Turkey
    J Pediatr Endocrinol Metab 19:1175-8. 2006
    ..A 14.6 year-old girl was diagnosed with nodular goiter, subclinical hypothyroidism and severe iodine deficiency. She had a very high hTG level...
  37. ncbi The advantage of near-total thyroidectomy to avoid postoperative hypoparathyroidism in benign multinodular goiter
    Yesim Erbil
    Istanbul Medical Faculty, Department of General Surgery, Istanbul University, 34340, Capa, Istanbul, Turkey
    Langenbecks Arch Surg 391:567-73. 2006
    ....
  38. ncbi Radiotherapy-induced thyroid disorders
    Barbara A Jereczek-Fossa
    Department of Radiation Oncology, European Institute of Oncology, 435 Via Ripamonti, 20141 Milan, Italy
    Cancer Treat Rev 30:369-84. 2004
    ..Further improvements in radiotherapy techniques and progress in endocrine diagnostics and therapy may allow better prevention and management of radiation-related thyroid injury...
  39. ncbi Thyroid tissue: US-guided percutaneous laser thermal ablation
    Claudio Maurizio Pacella
    Departments of Radiology and Diagnostic Imaging, Ospedale Regina Apostolorum, Via San Francesco 50, 00041 Albano Laziale, Rome, Italy
    Radiology 232:272-80. 2004
    ..To evaluate in vivo the safety and effectiveness of percutaneous laser thermal ablation (LTA) in the debulking of thyroid lesions...
  40. ncbi The newly developed three-dimensional (3D) and two-dimensional (2D) thyroid ultrasound are strongly correlated, but 2D overestimates thyroid volume in the presence of nodules
    T Rago
    Department of Endocrinology, University of Pisa, Pisa, Italy
    J Endocrinol Invest 29:423-6. 2006
    ..This intrinsic defect of 2D US should be taken into account when evaluating TV in patients with nodular goiter.
  41. pmc The minimally invasive open video-assisted approach in surgical thyroid diseases
    Massimo Ruggieri
    Department of Surgical Sciences and Applied Medical Technologies Francesco Durante, University of Rome La Sapienza, Rome, Italy
    BMC Surg 5:9. 2005
    ..This is due to less dissection and destruction of tissues. Pathologies treated are mainly nodular goiter; the only kind of thyroid cancer which may be approached with endoscopic surgery is a small differentiated ..
  42. ncbi Does Hurthle cell lesion/neoplasm predict malignancy more than follicular lesion/neoplasm on thyroid fine-needle aspiration?
    Robert T Pu
    Department of Pathology, Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Diagn Cytopathol 34:330-4. 2006
    ..0077). Our results suggest that an FNA diagnosis of HLN does not predict more malignancy than FLN. Males and older patients with a HLN FNA diagnosis carry a higher risk of Hurthle cell carcinoma upon thyroidectomy...
  43. ncbi [Treatment of hyperthyroidisms in Brazzaville Teaching Hospital, Congo]
    H G Monabeka
    Service des maladies métaboliques et endocriniennes CHU Brazzaville, Congo
    Bull Soc Pathol Exot 98:91-3. 2005
    ..Ten patients (8.5%/) underwent subtotal thyroidectomy, among them one developed hypothyroidism a year later. The result of this study shows that thyrotoxicosis is not a rare condition in Congo...
  44. pmc Marine-Lenhart syndrome
    Mehtap Cakir
    Division of Endocrinology and Metabolism, Selcuk University, Meram School of Medicine, Konya, Turkey
    J Natl Med Assoc 97:1036-8. 2005
    Graves' disease and toxic nodular goiter both cause thyrotoxicosis by different pathophysiological mechanisms. Cases with both etiologies have the diagnosis of Marine-Lenhart syndrome. Such a case is presented in this paper.
  45. ncbi Increased serum CXCL10 in Graves' disease or autoimmune thyroiditis is not associated with hyper- or hypothyroidism per se, but is specifically sustained by the autoimmune, inflammatory process
    Alessandro Antonelli
    Metabolism Unit, Department of Internal Medicine and CNR Institute of Clinical Physiology, University of Pisa School of Medicine, Via Roma, 67, I 56100, Pisa, Italy
    Eur J Endocrinol 154:651-8. 2006
    ..Longitudinal assessment of sCXCL10 in autoimmune hypo- or hyperthyroidism has not yet been performed...
  46. ncbi Gray-scale three-dimensional sonography of thyroid nodules: feasibility of the method and preliminary studies
    Rafal Z Slapa
    Department of Diagnostic Imaging, Medical Faculty II, Medical University of Warsaw, ul Kondratowicza 8, 03 242, Warsaw, Poland
    Eur Radiol 16:428-36. 2006
    ..41). Three-dimensional thin-slice surface rendering sonography appears to be a feasible and effective method for thyroid nodule evaluation...
  47. ncbi Thyroid surgery and recurrent laryngeal nerve monitoring
    S Bailleux
    Department of ENT and Maxillofacial Surgery, Pasteur Hospital, Nice, France
    J Laryngol Otol 120:566-9. 2006
    ..Recurrent laryngeal nerve paralysis is a much-dreaded complication of thyroid surgery...
  48. ncbi Low-energy interstitial laser photocoagulation for treatment of nonfunctioning thyroid nodules: therapeutic outcome in relation to pretreatment and treatment parameters
    Gerardo Amabile
    Unit of Thyroid Pathology Villa Cinzia, Naples, Italy
    Thyroid 16:749-55. 2006
    ..However, results supporting the routine use of ILP are still limited...
  49. ncbi Association of medullary and differentiated thyroid carcinomas
    A Rios
    Servicio de Cirugia General y del Aparato Digestivo I, Hospital Universitario Virgen de la Arrixaca, Avenida de la Libertad no 208, Casillas, 30007 Murcia, Spain
    Otolaryngol Head Neck Surg 135:473-5. 2006
  50. ncbi Radioiodine therapy in hyperthyroidism: inverse correlation of pretherapeutic iodine uptake level and post-therapeutic outcome
    M A Walter
    Institute of Nuclear Medicine, University Hospital Basel, Basel, Switzerland
    Eur J Clin Invest 34:365-70. 2004
    ..The aim of this study was to analyze the influence of RAI uptake on the outcome after RAI treatment and to estimate uptake-dependent success rates...
  51. ncbi [Update endocrinology: Thyroid sonography]
    P Bischof
    Innere Medizin, Spital Rorschach
    Praxis (Bern 1994) 93:695-700. 2004
    ..Clinical findings, laboratory results, ultrasonography and fine needle aspiration biopsy can be used alone or in combination, depending on the indication observed, to help find the accurate diagnosis...
  52. ncbi Fine needle aspiration of poorly differentiated oxyphilic (Hürthle cell) thyroid carcinoma: a case report
    Mohiedean Ghofrani
    Cytology Division, Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520 8023, USA
    Acta Cytol 50:560-2. 2006
    ..Although the histology of these rare thyroid tumors has been reported in the literature, the cytologic features on fine needle aspiration biopsy have not been described before...
  53. ncbi Ultrasound in head and neck surgery: thyroid, parathyroid, and cervical lymph nodes
    Alex Senchenkov
    Department of Surgery, Medical College of Ohio, 3065 Arlington Avenue, Toledo, OH 43614 5807, USA
    Surg Clin North Am 84:973-1000, v. 2004
    ..It has thus become an important adjunct to the practice of head and neck surgery...
  54. ncbi Radioiodine treatment of hyperthyroidism: prognostic factors affecting outcome
    Cihangir Erem
    Department of Internal Medicine, Division of Endocrinology and Metabolism, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey
    Endocrine 25:55-60. 2004
    ..To assess the effectiveness of radioactive iodine (RAI) treatment in patients with hyperthyroidism and to evaluate prognostic factors affecting outcome...
  55. ncbi [Endocrinology. II]
    Petra Maria Schumm-Draeger
    3 Medizinische Abteilung, Endokrinologie, Diabetologie und Angiologie, Krankenhaus Munchen Bogenhausen, München Bogenhausen
    Med Klin (Munich) 99:372-82. 2004
  56. ncbi Clinical implementation of endoscopic thyroidectomy in selected patients
    David J Terris
    Department of Otolaryngology Head and Neck Surgery, Medical College of Georgia, Augusta, Georgia, USA
    Laryngoscope 116:1745-8. 2006
    ..Systematic investigation of minimal access thyroid compartment surgery combined with the advent of several key new technologies has culminated in the implementation of endoscopic thyroidectomy in specific clinical situations...
  57. ncbi Effectiveness of radioiodine (131-I) as definitive therapy in patients with autoimmune and non-autoimmune hyperthyroidism
    B Tarantini
    Section of Endocrinology and Metabolism, Department of Internal Medicine, Endocrinology and Metabolism and Biochemistry, University of Siena, 53100 Siena, Italy
    J Endocrinol Invest 29:594-8. 2006
    ..No influence was found between outcome and clinical parameters at the moment of 131-I therapy. In conclusion, our results indicate that RAI therapy is highly effective and safe for the control of hyperthyroidism...
  58. ncbi [The role of intraoperative parathyroid hormone assay in the surgical management of hyperparathyroidism]
    R Balzano
    II Divisione di Chirurgia Generale, Spedali Civili di Brescia
    G Chir 25:242-4. 2004
    ....
  59. ncbi [Quantification of the risk of relapses after thyroid loboisthmusectomy for benign thyroid nodules]
    Gregorio Scerrino
    Universita degli Studi di Palermo, Facolta di Medicina e Chirurgia, Dipartimento GEN UR TO, Unità Operativa di Chirurgia Generale e d Urgenza
    Ann Ital Chir 76:321-8; discussion 328-9. 2005
    ..To evaluate correlations between pre-operating epidemiological, clinical and diagnostic data and relapses concerning to patients operated on for benign thyroid nodules...
  60. ncbi [The expression of G proteins alpha-subunit mRNA in different thyroid diseases]
    Zhao Hui Lu
    Department of Endocrinology, Chinese PLA General Hospital, Beijing 100853, China
    Zhonghua Nei Ke Za Zhi 42:103-5. 2003
    ..To investigate the expression of G proteins alpha subunit mRNA in different thyroid diseases...
  61. ncbi [A comparative study of cytological and histological studies of the thyroid gland]
    P Emmrich
    ,
    Zentralbl Chir 126:267-72. 2001
    ..Preoperative fine-needle aspiration cytology of the thyroid gland reduces the number of patients operated on for multinodular goitre or cold nodules especially in cases suspicious of carcinoma...
  62. ncbi Multinodular goiter: surgical management and histopathological findings
    Jean Michel Prades
    Department of Otolaryngology, Head and Neck Surgery, Bellevue Hospital, St Etienne University Hospital Center, France
    Eur Arch Otorhinolaryngol 259:217-21. 2002
    ..1%). Our results suggest that near total thyroidectomy with minimal residual tissue is a versatile surgical procedure for various histopathological features in MNG patients. Low rates of postoperative complications were observed...
  63. ncbi Differentiated thyroid carcinoma in children and adolescents. Clinical characteristics, treatment and outcome of 15 patients
    Cumhur Arici
    Department of General Surgery, Akdeniz University Medical Faculty, Antalya, Turkey
    Horm Res 57:153-6. 2002
    ..The aim of this study was to perform a retrospective analysis of treatment results for differentiated thyroid carcinoma in this age group treated in our clinic...
  64. ncbi Blood coagulation and fibrinolysis in patients with hyperthyroidism
    C Erem
    Division of Endocrinology and Metabolism, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey
    J Endocrinol Invest 25:345-50. 2002
    ..Hyperthyroid patients may experience vascular endothelial dysfunction and decreased fibrinolytic activity in blood. This endothelial activation may represent a situation with a higher thromboembolic potential...
  65. ncbi [The management of thyrotoxicosis: a schematic approach]
    G Papi
    Dipartimento di Medicina Interna, AUSL Modena, Ospedale Ramazzini, Carpi, Italy
    Minerva Endocrinol 27:119-26. 2002
    ..authors propose to begin therapy whether subclinical thyrotoxicosis develop in the following four subgroups of subjects: patients with nodular goiter; women in post-menopause; patients with cardiac diseases; patients with osteoporosis.
  66. ncbi Gamma probe-guided surgery for revision thyroidectomy: in comparison with conventional technique
    Y Erbil
    Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, CAPA 34390 Istanbul, Turkey
    J Endocrinol Invest 28:583-8. 2005
    ..02). These results indicate that intraoperative gamma probe application may be beneficial to detect and remove residual thyroid tissue in revision thyroidectomy...
  67. ncbi [Thyroid autonomy, cyst or thyroid cancer]
    Klaus Mann
    Klinik fur Endokrinologie, Zentrum für Innere Medizin Universität Duisburg Essen
    MMW Fortschr Med 150:25, 27-29; quiz 30. 2008
  68. ncbi [Unifocal autonomy and carcinoma of the thyroid gland]
    P Emmrich
    ,
    Zentralbl Chir 126:672-5. 2001
    ..These cases show that under the clinical diagnosis of AFTN a differentiated thyroid carcinoma can be hidden occasionally...
  69. ncbi Effect of thyroid gland volume in preoperative detection of suspected malignant thyroid nodules in a multinodular goiter
    Yesim Erbil
    Department of General Surgery, Istanbul Medical Faculty, University of Istanbul, 34340 Capa, Istanbul, Turkey
    Arch Surg 143:558-63; discussion 563. 2008
    ..The detection of suspected malignant thyroid nodules by ultrasonography is associated with thyroid gland volume and tumor size...
  70. ncbi Utility of I-123 thyroid uptake scan in incidental thyroid nodules: an old test with a new role
    Scott M Wilhelm
    Division of Surgical Oncology, University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA
    Surgery 144:511-5; discussion 515-7. 2008
    ..In an incidentally discovered multinodular thyroid goiter, determining which nodule to biopsy is challenging. This study examined whether I-123 thyroid uptake scans (TUS) could guide this biopsy...
  71. ncbi Thyroidectomy or radioiodine? The value of ultrasonography and cytology in the assessment of nodular lesions in Graves' hyperthyroidism
    C Y Wang
    Graduate Institute of Physiology, College of Medicine, National Taiwan University, Taipei
    Am Surg 67:721-6. 2001
    ..Twenty-seven consecutive GD patients with nodular goiter were included in this study (21 women and six men, mean age 41.2 years, range 22-77 years)...
  72. ncbi Solitary adrenal gland metastasis of a follicular thyroid carcinoma presenting with hyperthyroidism
    P J Yunta
    Service de Chirurgie, , La Fe, Avda. Campanar 21, 46009 Valencia, Espagne
    Ann Endocrinol (Paris) 62:226-9. 2001
    ..A (131)I whole body scan is the diagnostic method of choice for functioning thyroid metastasis...
  73. doi [Malignant goiter--thyroid cancer]
    Chr Reiners
    Klinik und Poliklinik fur Nuklearmedizin, Universitat Wurzburg
    Dtsch Med Wochenschr 133:2215-28; quiz 2229-30. 2008
  74. ncbi Multinodular goiter in children
    S Al-Fifi
    Department of Child Health, College of Medicine, King Khalid University, Abha, Saudi Arabia
    J Pediatr Endocrinol Metab 14:749-56. 2001
    ..Ultrasound at the time of diagnosis and in follow up seems beneficial. Familial forms appear to warrant close follow up, given the apparent increased risk of malignancy. The risk of malignancy while low remains real...
  75. ncbi Telomerase activity and telomere length in thyroid neoplasia: biological and clinical implications
    P Matthews
    Department of Pathology, University of Wales College of Medicine, Cardiff CF14 4XN, UK
    J Pathol 194:183-93. 2001
    ..From a clinical standpoint, it is concluded that telomerase detection on unfractionated tissue, such as fine needle aspirates, is of no value as a marker of malignancy in follicular lesions, due to both low sensitivity and specificity...
  76. ncbi The incidence of hyperthyroidism in patients with thyroid cancer in an area of iodine deficiency
    Mehmet Ali Gulcelik
    Department of General Surgery, Ankara Oncology Training and Research Hospital, Ankara, Turkey
    J Surg Oncol 94:35-9. 2006
    ..The aim of the study was to evaluate the association of hyperthyroidism and thyroid cancer (TC) in an iodine deficient area...
  77. ncbi Hyperthyroidism and concurrent thyroid cancer
    R Vaiana
    Second Division of General Surgery, Spedali Civili, Brescia, Italy
    Tumori 85:247-52. 1999
    ....
  78. ncbi [The thyroid pyramidal lobe: frequency, morphological features and related diseases]
    Giovanni Sturniolo
    Cattedra di Chirurgia Generale, UOC di Chirurgia Generale a Indirizzo Endocrino, Universita degli Studi di Messina, Messina
    Chir Ital 60:41-6. 2008
    ..5% of cases, mostly in women, the primary disease invariably arising from the main gland. The Authors conclude that the pyramidal lobe is an embryological remnant which may be involved in diseases arising from the main gland...
  79. ncbi Surgical management of thyroid diseases--a study on 78 cases
    M Monwar Hossain
    Department of ENT, MMC, Mymensingh
    Mymensingh Med J 11:6-8. 2002
    ..4%) patients. The study showed that females were the mostly affected group having benign single cold nodular goitre who were treated surgically by hemithyroidectomy...
  80. ncbi Thyroid nodular disease: an emerging problem
    E De Martino
    Dipartimento di Scienze Mediche e Chirurgiche, II Divisione di Medicina Interna ed Endocrinologia, Universita degli Studi di Brescia, Spedali Civili Brescia, Italia
    Minerva Endocrinol 33:15-25. 2008
    ..Aim of this work is to delineate a rational approach to thyroid nodules, taking in account literature data, the most recent guidelines and our clinical experience...
  81. ncbi Medullary thyroid carcinoma: a rare presentation as a hypervascular tumour
    W Y Li
    Department of General Surgery, Crawley Hospital, West Sussex, UK
    J Laryngol Otol 116:647-9. 2002
    ..The management of hypervascular thyroid tumours is discussed together with current controversies regarding persistent hypercalcitoninaemia...
  82. ncbi [Current indications for thyroidectomy]
    G Dionigi
    Centro di Ricerche in Endocrinochirurgia, Dipartimento di Scienze Chirurgiche, Universita degli Studi dell Insubria, Varese
    Minerva Chir 62:359-72. 2007
    ....
  83. ncbi Recombinant human thyroid-stimulating hormone: pharmacology, clinical applications and potential uses
    Charles H Emerson
    Department of Medicine, University of Massachusetts School of Medicine, Worcester, Massachusetts 01655, USA
    BioDrugs 17:19-38. 2003
    ..In the future, TSH analogues that have superagonist or antagonist properties may become available as therapeutic agents...
  84. ncbi Transient hypoparathyroidism following thyroidectomy: a prospective study and multivariate analysis of 604 consecutive patients
    Ottavio Cavicchi
    ENT Department, S Orsola Malpighi Hospital, Bologna University, Bologna, Italy
    Otolaryngol Head Neck Surg 137:654-8. 2007
    ..The purpose of this study was to identify the risk factors for postoperative transient hypoparathyroidism in a group of patients undergoing thyroid surgery...
  85. ncbi False-positive I-131 accumulation in a hepatic hydatid cyst
    Ozgur Omur
    Department of Nuclear Medicine, Ege University Medical Faculty, Bornova Izmir, Turkey
    Clin Nucl Med 32:930-2. 2007
    ..Hepatic cystic mass was removed, and postoperative histologic evaluation confirmed hydatid disease. Some cystic lesions of the kidney and liver have been previously reported as causes of false-positive radioiodine accumulation...
  86. ncbi [Diagnosis of thyroid disease. Part 2: thyroid gland nodes, diagnosis and treatment of thyroid carcinoma]
    S Delorme
    Abteilung für Onkologische Diagnostik und Therapie, Deutsches Krebforschungszentrum, Heidelberg
    Radiologe 43:179-94; quiz 194-5. 2003
  87. ncbi Contemporary diagnostic approach to the thyroid nodule
    Jennifer E Rosen
    Department of Surgery, Section of Surgical Oncology, Boston University School of Medicine, 88 East Newton Street D605, Boston, MA 02118, USA
    J Surg Oncol 94:649-61. 2006
    ..Given how many questions still exist for patients with thyroid nodules, partnership and collaboration, or the "bench to bedside" concept should find its way into most every thyroid surgeon and endocrinologist's lexicon...
  88. ncbi Radioiodine therapy of thyroid autonomy
    Christoph Reiners
    Clinic and Policlinic for Nuclear Medicine, University of Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Eur J Nucl Med Mol Imaging 29:S471-8. 2002
    ..Therapy-related risks, such as immunogenic hypothyroidism or thyroid cancer, are discussed. (131)I treatment of functional autonomy and hyperthyroidism is considered an effective and safe procedure...
  89. ncbi [Reoperations of the thyroid gland]
    M R Diaconescu
    Clinica a IV a Chirurgie, Universitatea de Medicină si Farmacie Gr T Popa Iaşi
    Chirurgia (Bucur) 102:297-302. 2007
    ....
  90. ncbi [Ultrasonography-guided therapeutic procedures in the neck region]
    Hrvojka Tomić Brzac
    Klinicki zavod za nuklearnu medicinu i zastitu od zracenja, Klinicki bolnicki centar Zagreb, Zagreb, Hrvatska
    Acta Med Croatica 63:21-7. 2009
    ..Other methods like laser photocoagulation (ILP) or radiofrequency ablation (RFA) are more aggressive and expensive...
  91. ncbi Serum insulin-like growth factor-I, insulin-like growth factor binding proteins, and bone mineral content in hyperthyroidism
    P Lakatos
    1st Department of Medicine, Semmelweis University Medical School, Budapest, Hungary
    Thyroid 10:417-23. 2000
    ..who had recently been diagnosed with hyperthyroidism (age: 29-67 years; 19 with Graves' disease, 17 with toxic nodular goiter) and 36 age-matched healthy women as controls...
  92. ncbi 99mTc-MIBI radio-guided minimally invasive parathyroidectomy: experience with patients with normal thyroids and nodular goiters
    Dario Casara
    Nuclear Medicine Service, Radiotherapy Department, Azienda Ospedaliera di Padova, Italy
    Thyroid 12:53-61. 2002
    ..was utilized during a standard bilateral neck exploration (BNE) because of the presence of concomitant nodular goiter (11 cases) or multiglandular disease (MGD) (3 cases)...
  93. ncbi Analysis of changes in the percentage of B (CD19) and T (CD3) lymphocytes, subsets CD4, CD8 and their memory (CD45RO), and naive (CD45RA) T cells in children with immune and non-immune thyroid diseases
    Artur Bossowski
    2nd Department of Children s Diseases, Medical Academy of Białystok, Poland
    J Pediatr Endocrinol Metab 16:63-70. 2003
    ..9 +/- 5.9 years) and non-toxic nodular goiter (NTNG) (n = 25, mean age 15...
  94. ncbi [Expression of mucin-l and beta-catenin in papillary thyroid carcinoma and the clinical significance thereof]
    Fei He
    Department of Endocrinology, Taizhou Municipal Hospital, Taizhou 318000, China
    Zhonghua Yi Xue Za Zhi 89:393-6. 2009
    ..To investigate the expression levels of mucin-1 (MUC1) and beta-catenin in papillary thyroid carcinoma, the significance thereof in the carcinogenesis and development of tumor...
  95. ncbi The value of ultrasonography in predicting autoimmune thyroid disease
    O M Pedersen
    Department of Clinical Biology, Haukeland Hospital, University of Bergen, Norway
    Thyroid 10:251-9. 2000
    ..in 352 patients; Graves' disease in 47 patients; subacute (granulomatous) thyroiditis in 7 patients; toxic nodular goiter in 3 patients; and toxic adenoma in 2 patients...
  96. ncbi [Expression of TTF-1 in thyroid tumors originating from follicular epithelium and its correlation with expression of RET, galectin-3 and mucin-1 genes]
    Yun Chen
    Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
    Zhonghua Yi Xue Za Zhi 82:257-61. 2002
    ....
  97. ncbi Relapses of hyperthyroidism in patients treated with radioiodine for nodular toxic goiter: relation to thyroid autoimmunity
    N Custro
    Institute of Internal Medicine and Geriatrics, University of Palermo, Italy
    J Endocrinol Invest 26:106-10. 2003
    Relapses of hyperthyroidism after treatment with radioiodine for uni- or multi-nodular goiter may be accompanied by the appearance of TSAb...
  98. ncbi Identification of a novel point mutation in the RET gene (Ala883Thr), which is associated with medullary thyroid carcinoma phenotype only in homozygous condition
    Rossella Elisei
    Department of Endocrinology, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    J Clin Endocrinol Metab 89:5823-7. 2004
    ..The mother (82 yr old) showed a nodular goiter but was negative both for basal and pentagastrin stimulated calcitonin...
  99. ncbi Thyroid disorders in hemodialysis patients in an iodine-deficient community
    Sim Kutlay
    Department of Nephrology, Ankara University School of Medicine, Ankara, Turkey
    Artif Organs 29:329-32. 2005
    ..Between patients with or without a nodular goiter the authors could not observe any difference for duration of dialysis and serum levels of TSH, FT4, FT3, ..
  100. ncbi Th1 and Th2 serum cytokine profiles characterize patients with Hashimoto's thyroiditis (Th1) and Graves' disease (Th2)
    Costas Phenekos
    Department of Endocrinology, Red Cross Hospital, Athens, Greece
    Neuroimmunomodulation 11:209-13. 2004
    The aim of this study was to document the pattern of immune response, assessed by the measurement of both Th1 and Th2 serum cytokines, in patients suffering from autoimmune thyroid disease and toxic nodular goiter.
  101. ncbi Increased thrombin-activatable fibrinolysis inhibitor and decreased tissue factor pathway inhibitor in patients with hyperthyroidism
    Cihangir Erem
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Karadeniz Technical University Faculty of Medicine, K T Ü Tıp Fakültesi, Ic Hastaliklari Anabilim Dali, 61080 Trabzon, Turkey
    Endocrine 36:473-8. 2009
    ..001 for all of them). We did not find a significant difference between Graves' disease and toxic nodular goiter for hemostatic parameters...

Research Grants4

  1. MOLECULAR GENETIC STUDIES OF THYROID CELL LINES
    Duncan Ferguson; Fiscal Year: 1993
    ..objectives of these studies are to establish spontaneous feline hyperfunctional adenomatous goiter (toxic nodular goiter) as a model for human benign thyroid tumors, and to probe for molecular genetic abnormalities associated with ..
  2. THYROID HORMONE REGULATION OF MOUSE SOMATOSTATIN TYPE 5
    WHITNEY WOODMANSEE; Fiscal Year: 2004
    ..The institution and her mentors provide a supportive setting for her to flourish as a physician- scientist. ..
  3. Regulation of Mouse Somatostatin Receptor Subtype 5 Gene
    WHITNEY WOODMANSEE; Fiscal Year: 2004
    ..abstract_text> ..
  4. Extracellular matrix and protease markers of malignant thyroid neoplasm
    Electron Kebebew; Fiscal Year: 2007
    ..We will use these results to design a multicenter clinical trial evaluating the diagnostic and prognostic value of ECM1 and TMPRSS4 expression in patients with thyroid neoplasm. [unreadable] [unreadable] [unreadable]..