Genomes and Genes
Summary: A state of intersex or sexual ambiguity, involving the GENOTYPE, the GONADS, the reproductive tract, and/or the external GENITALIA or PHENOTYPE. This concept covers TRUE HERMAPHRODITISM and PSEUDOHERMAPHRODITISM. True hermaphrodites are rare and they possess gonadal tissues of both SEXES, tissues from the OVARY and the TESTIS. Pseudohermaphrodites possess gonadal tissue of one sex but exhibit external phenotype of the opposite sex.
Publications217 found, 100 shown here
- Evidence of a mate-finding cue in the hermaphrodite nematode Caenorhabditis elegansJasper M Simon
Division of Biology and Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125, USA
Proc Natl Acad Sci U S A 99:1598-603. 2002..Finally, that males from multiple isolates of C. elegans also respond similarly to this cue indicates that this cue is robust and has been maintained during recent evolution...
- Temporal dynamics and linkage disequilibrium in natural Caenorhabditis elegans populationsAntoine Barrière
Institut Jacques Monod, CNRS Universities of Paris 6 and 7, 75251 Paris Cedex 05, France
Genetics 176:999-1011. 2007..C. elegans seems to follow metapopulation dynamics, and the maintenance of linkage disequilibrium despite a low yet significant level of outcrossing suggests that selection may act against the progeny of outcrossings...
- Altered sexual maturation and gamete production in wild roach (Rutilus rutilus) living in rivers that receive treated sewage effluentsS Jobling
Department of Biological Sciences, Brunel University, Uxbridge, Middlesex UB8 3PH, United Kingdom
Biol Reprod 66:272-81. 2002....
- Selection and maintenance of androdioecy in Caenorhabditis elegansAndrew D Stewart
Department of Biology, University of Texas, Arlington, Texas 76019 0498, USA
Genetics 160:975-82. 2002..Factors such as variation in male mating ability and inbreeding depression could potentially lead to the long-term maintenance of males...
- A CUL-2 ubiquitin ligase containing three FEM proteins degrades TRA-1 to regulate C. elegans sex determinationNatalia G Starostina
Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA
Dev Cell 13:127-39. 2007..This work demonstrates that the terminal step in C. elegans sex determination is controlled by ubiquitin-mediated proteolysis...
- Transgenic zebrafish with fluorescent germ cell: a useful tool to visualize germ cell proliferation and juvenile hermaphroditism in vivoChung Der Hsiao
Institute of Molecular and Cell Biology, and Institute of Fisheries Science, National Taiwan University, 1 Roosevelt Road, Section 4, 106, Taipei, Taiwan
Dev Biol 262:313-23. 2003..In order to fully capture the dynamic processes of germ cells' proliferation and juvenile hermaphroditism in zebrafish, we established transgenic lines TG(beta-actin:EGFP), harboring an enhanced green fluorescent ..
- Anticonvulsant medications extend worm life-spanKimberley Evason
Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
Science 307:258-62. 2005..These findings suggest that the life-span-extending activity of these compounds is related to the anticonvulsant activity and implicate neural activity in the regulation of aging...
- Diversity in mating behavior of hermaphroditic and male-female Caenorhabditis nematodesL Rene Garcia
Department of Biology, Texas A and M University, College Station, Texas 77843 3258, USA
Genetics 175:1761-71. 2007....
- Caenorhabditis phylogeny predicts convergence of hermaphroditism and extensive intron lossKarin Kiontke
Department of Biology, New York University, 100 Washington Square East, New York, NY 10003, USA
Proc Natl Acad Sci U S A 101:9003-8. 2004..a well resolved phylogeny that reveals three striking patterns in the evolution of this animal group: (i) Hermaphroditism has evolved independently in C...
- fog-2 and the evolution of self-fertile hermaphroditism in CaenorhabditisSudhir Nayak
Department of Genetics, Washington University School of Medicine St Louis, Missouri, USA
PLoS Biol 3:e6. 2005..briggsae, providing functional evidence in support of the independent evolution of self-fertile hermaphroditism. We speculate on the convergent evolution of hermaphroditism in Caenorhabditis based on the plasticity of the ..
- Mus poschiavinus Y chromosome in the C57BL/6J murine genome causes sex reversalE M Eicher
Science 217:535-7. 1982
- The genetics of caloric restriction in Caenorhabditis elegansB Lakowski
Department of Biology, McGill University, 1205 Dr Penfield Avenue, Montreal, Quebec, Canada H3A 1B1
Proc Natl Acad Sci U S A 95:13091-6. 1998..In contrast, we find that food restriction does not further increase the life span of long-lived clk-1 mutants, suggesting that clk-1 and caloric restriction affect similar processes...
- Elevated serum vitellogenin levels and gonadal abnormalities in wild male flounder (Pleuronectes yokohamae) from Tokyo Bay, JapanS Hashimoto
Department of Ocean Sciences, Tokyo University of Fisheries, 4 5 7 Konan, Minato ku, Tokyo 108 8477, Japan
Mar Environ Res 49:37-53. 2000..This study suggests that the abnormally high levels of VTG and the presence of oocytes in the testis of male flounder collected from Tokyo Bay could be the effect of environmental estrogens...
- Mate searching in Caenorhabditis elegans: a genetic model for sex drive in a simple invertebrateJonathan Lipton
Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Neurosci 24:7427-34. 2004..left food, in two cases with similar frequency, suggesting coordinate evolution of behavioral dimorphism with hermaphroditism. We use a quantitative behavioral assay to show that C...
- X-chromosome silencing in the germline of C. elegansWilliam G Kelly
Biology Department, Emory University, Atlanta, GA 30322, USA
Development 129:479-92. 2002..Silencing of the sex chromosome during early meiosis is a conserved feature throughout the nematode phylum, and is not limited to hermaphroditic species...
- Regulation of sperm activation by SWM-1 is required for reproductive success of C. elegans malesGillian M Stanfield
Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA
Curr Biol 16:252-63. 2006..In nematodes, spermiogenesis, or sperm activation, involves a rapid cellular morphogenesis that converts unpolarized round spermatids into polarized amoeboid spermatozoa capable of both motility and fertilization...
- A blend of small molecules regulates both mating and development in Caenorhabditis elegansJagan Srinivasan
Howard Hughes Medical Institute and Biology Division, California Institute of Technology, 1200 E California Boulevard, Pasadena, California 91125, USA
Nature 454:1115-8. 2008..The ascaroside signalling system thus connects reproductive and developmental pathways and represents a unique example of structure- and concentration-dependent differential activity of signalling molecules...
- A genetic pathway for the development of the Caenorhabditis elegans HSN motor neuronsC Desai
Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
Nature 336:638-46. 1988..Nearly all are pleiotropic, revealing that the genes specifying HSN development also function in the development of other cell types...
- Genome-wide germline-enriched and sex-biased expression profiles in Caenorhabditis elegansValerie Reinke
Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
Development 131:311-23. 2004..Comparison with data from large-scale RNAi screens demonstrates that genes expressed in the oogenic germline display visible phenotypes more frequently than expected...
- FOG-2, a novel F-box containing protein, associates with the GLD-1 RNA binding protein and directs male sex determination in the C. elegans hermaphrodite germlineR Clifford
Department of Genetics, Washington University School of Medicine, Campus Box 8232, St Louis, MO 63110, USA
Development 127:5265-76. 2000..fog-2 may have arisen during evolution of self-fertile hermaphroditism from an ancestral female/male species.
- A sperm cytoskeletal protein that signals oocyte meiotic maturation and ovulationM A Miller
Department of Cell Biology, Mass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Science 291:2144-7. 2001..Proteins with MSP-like domains are found in plants, fungi, and other animals, suggesting that related signaling functions may exist in other phyla...
- Effects of endocrine disruptors on prosobranch snails (Mollusca: Gastropoda) in the laboratory. Part III: Cyproterone acetate and vinclozolin as antiandrogensM Tillmann
Internationales Hochschulinstitut Zittau, Lehrstuhl Umweltverfahrenstechnik, Fachgruppe Human- und Okotoxikologie, Markt 23, D-02763 Zittau, Germany
Ecotoxicology 10:373-88. 2001..Compared with estrogens and androgens, the antiandrogen responses seem to be less drastic and might have--in contrast to the two other disruptor classes--no biologically significant effects at the population level...
- Genetic flexibility in the convergent evolution of hermaphroditism in Caenorhabditis nematodesRobin Cook Hill
Department of Biology, University of Maryland, College Park, 20742, USA
Dev Cell 10:531-8. 2006..These findings are consistent with convergent evolution of hermaphroditism, which is marked by considerable developmental genetic flexibility.
- Changes in the reproductive system of the snail Helix aspersa caused by mucus from the love dartJ M Koene
Department of Biology, McGill University, Montreal Quebec, H3A 1B1 Canada
J Exp Biol 201:2313-9. 1998..By influencing the female organs involved in the processing of foreign sperm, the dart shooter may increase the chance that his sperm will fertilise eggs...
- Molecular evolution in Panagrolaimus nematodes: origins of parthenogenesis, hermaphroditism and the Antarctic species P. davidiSamantha C Lewis
Department of Zoology and Center for Genome Research and Biocomputing, Oregon State University, Corvallis, Oregon 97331, USA
BMC Evol Biol 9:15. 2009..The evolutionary origins of these varying reproductive modes and the Antarctic species P. davidi, however, remain enigmatic...
- Parasites and the evolution of self-fertilizationA F Agrawal
Department of Biology, Indiana University, Bloomington 47405 3700, USA
Evolution 55:869-79. 2001..In addition, mixed mating, where it exits, tends to be biased toward selfing...
- Alterations to gonadal development and reproductive success in Japanese medaka (Oryzias latipes) exposed to 17alpha-ethinylestradiolGordon C Balch
Environmental and Resource Studies Program, Trent University, Peterborough, Ontario K9J 7B8, Canada
Environ Toxicol Chem 23:782-91. 2004..However, it is clear that concentrations of endocrine disrupting chemicals (EDCs) that cause gonadal intersex are sufficient to reduce reproductive performance...
- First observation of intersex cyprinids in the Po River (Italy)L Vigano
Istituto di Ricerca Sulle Acque, CNR, Brugherio Milan, Italy
Sci Total Environ 269:189-94. 2001..In fact, 50% of the barbel captured (8 of 16 fish) in the downstream reach showed intersex gonads...
- Management of the African child with true hermaphroditismR Wiersma
Department of Paediatric Surgery, University of Natal, Durban, South Africa
J Pediatr Surg 36:397-9. 2001BACKGROUND/PURPOSE: A disproportionally high incidence of true hermaphroditism is seen among the South African black people, constituting 51% of children in local study on all intersex types...
- Limited effectiveness of marine protected areas: imposex in Hexaplex trunculus (Gastropoda, Muricidae) populations from Italian marine reservesA Terlizzi
Laboratory of Zoology and Marine Biology, Department of Biological and Environmental Science and Technology, University of Lecce, CoNISMa, Strada Prov le Monteroni, Lecce 73100, Italy
Mar Pollut Bull 48:188-92. 2004
- Mechanisms of imposex induction in the mud snail, Ilyanassa obsoleta: TBT as a neurotoxin and aromatase inhibitorEva Oberdörster
Southern Methodist University, Dallas, TX 75275 0376, USA
Mar Environ Res 54:715-8. 2002..Although the role of vertebrate sex steroids is not known in gastropods, it is possible that the combination of changes in peptide and steroid hormones may lead to imposex induction at extremely low doses of TBT...
- Widespread genetic incompatibility in C. elegans maintained by balancing selectionHannah S Seidel
Lewis Sigler Institute for Integrative Genomics and Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA
Science 319:589-94. 2008..Our data suggest that long-term maintenance of a balanced polymorphism has permitted the incompatibility to persist despite gene flow across the rest of the genome...
- Endocrine disruption and altered gonadal development in white perch (Morone americana) from the lower Great Lakes regionRichard J Kavanagh
Environmental and Resource Studies, Trent University, 1600 West Bank Drive, Peterborough, Ontario K9J 7B8, Canada
Environ Health Perspect 112:898-902. 2004..These observations indicate that male white perch are exposed to estrogenic endocrine-disrupting substances that may be responsible for the induction of gonadal intersex...
- A cytogenetic investigation of inherited true hermaphroditism in BALB/cWt miceE M Eicher
Cytogenet Cell Genet 28:104-15. 1980A predictably high incidence of true hermaphroditism (3%) among fetal BALB/cWt mice provided the opportunity for studying the cause of inherited hermaphroditism...
- Molecular analysis in true hermaphroditism: demonstration of low-level hidden mosaicism for Y-derived sequences in 46,XX casesGloria Queipo
Hospital General de Mexico Facultad de Medicina, UNAM, Dr Balmis 148 Col Doctores CP 06726, Mexico City, Mexico
Hum Genet 111:278-83. 2002True hermaphroditism (TH) is an unusual form of sex reversal, characterized by the development of testicular and ovarian tissue in the same subject...
- gld-1, a tumor suppressor gene required for oocyte development in Caenorhabditis elegansR Francis
Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
Genetics 139:579-606. 1995..This function of gld-1 is inferred from a haplo-insufficient phenotype and from the properties of gain-of-function gld-1 mutations that cause alterations in the sexual identity of germ cells...
- Consensus statement on management of intersex disordersI A Hughes
Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital, Box 116, Level 8, Hills Road, Cambridge CB2 2QQ, UK
Arch Dis Child 91:554-63. 2006
- Animals mix it up too: the distribution of self-fertilization among hermaphroditic animalsPhilippe Jarne
Centre d Ecologie Fonctionnelle et Evolutive, Centre National de la Recherche Scientifique, 1919 Route de Mende, 34293, Montpellier 5, France
Evolution 60:1816-24. 2006Excluding insects, hermaphroditism occurs in about one-third of animal species, providing numerous opportunities for the evolution of selfing...
- Sediments are major sinks of steroidal estrogens in two United Kingdom riversMika Peck
University of Sussex, Department of Chemistry, Physics and Environmental Science, Falmer, Brighton BN1 9QJ, United Kingdom
Environ Toxicol Chem 23:945-52. 2004..These results suggest that riverine sediments are a major sink and a potential source of persistent estrogenic contaminants...
- Experimental insight into the proximate causes of male persistence variation among two strains of the androdioecious Caenorhabditis elegans (Nematoda)Viktoria Wegewitz
Department of Evolutionary Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
BMC Ecol 8:12. 2008..In the standard laboratory wild type strain N2 males disappear rapidly from populations. This is not the case in some other wild type isolates of C. elegans, among them the Hawaiian strain CB4856...
- Exploring the envelope. Systematic alteration in the sex-determination system of the nematode caenorhabditis elegansJonathan Hodgkin
Genetics Unit, Department of Biochemistry, University of Oxford, United Kingdom
Genetics 162:767-80. 2002..The creation of these strains demonstrates the ease with which one sex-determination system can be transformed into another...
- Phenotypically flexible sex allocation in a simultaneous hermaphroditeVerena S Brauer
Department of Evolutionary Biology, University of Muenster, Huefferstrasse 1, 48149 Muenster, Germany
Evolution 61:216-22. 2007..We argue that phenotypically flexible sex allocation in hermaphroditic animals may help us to understand the evolution and ecology of hermaphroditism.
- Sexual disruption in a second species of wild cyprinid fish (the gudgeon, Gobio gobio) in United Kingdom freshwatersR van Aerle
Environmental and Molecular Fish Biology, School of Biological Sciences, University of Exeter, United Kingdom
Environ Toxicol Chem 20:2841-7. 2001..Together with the findings in the roach, these data on the gudgeon confirm that sexual disruption in fish in UK rivers is not species specific...
- Herbicides: feminization of male frogs in the wildTyrone Hayes
Laboratory for Integrative Studies in Amphibian Biology, Museum of Vertebrate Zoology, and Department of Integrative Biology, University of California, Berkeley, California 94720 3140, USA
Nature 419:895-6. 2002
- Reproductive uncertainty and the relative competitiveness of simultaneous hermaphroditism versus dioecyW G Wilson
1 Department of Biology, Duke University, Durham, North Carolina 27708, USA
Am Nat 162:220-41. 2003b>Hermaphroditism is typically associated with a sedentary existence, whereas dioecy is associated with mobility. This pattern is reflected within flowering plants, as dioecious species commonly possess traits that promote high dispersal...
- Regulation of distinct muscle behaviors controls the C. elegans male's copulatory spicules during matingL R Garcia
Howard Hughes Medical Institute, Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
Cell 107:777-88. 2001..The male gonad then lengthens the duration of EGL-19-mediated prolonged muscle contraction. This regulation of muscle contraction provides a paradigm to explain how animals initiate, monitor, and maintain a behavioral motor program...
- True hermaphroditism and mixed gonadal dysgenesis in young children: a clinicopathologic study of 10 casesKyu Rae Kim
Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
Mod Pathol 15:1013-9. 2002True hermaphroditism (TH) refers to individuals who have both unequivocal ovarian tissue and testicular elements regardless of their karyotypes; whereas mixed gonadal dysgenesis (MGD) refers to individuals who usually have a ..
- Every sperm is sacred: fertilization in Caenorhabditis elegansA Singson
Waksman Institute and Department of Genetics, Rutgers University, Piscataway, New Jersey, 08854, USA
Dev Biol 230:101-9. 2001..This review describes progress in the genetic and molecular dissection of fertilization in C. elegans and related studies on sperm competition...
- The C. elegans spe-9 gene encodes a sperm transmembrane protein that contains EGF-like repeats and is required for fertilizationA Singson
Department of Biology, Emory University, Atlanta, Georgia 30322, USA
Cell 93:71-9. 1998..These results suggest that SPE-9 functions in the specialized cell-cell interactions required for fertilization...
- Testing three models on the adaptive significance of protandric simultaneous hermaphroditism in a marine shrimpJ Antonio Baeza
Department of Biology, The University of Louisiana at Lafayette, Lafayette, Louisiana 70504 2451, USA
Evolution 60:1840-50. 2006Protandric simultaneous hermaphroditism, as reported for shrimps in the genus Lysmata, is a sexual system in which individuals invariably reproduce as males first and later in life as simultaneous hermaphrodites. I tested three models (i...
- Sperm competition in the absence of fertilization in Caenorhabditis elegansA Singson
Department of Biology, Emory University, Atlanta, Georgia 30322, USA
Genetics 152:201-8. 1999..The sperm competition assays described in this study will be useful in further classifying the large number of currently identified mutations that alter sperm function and development in C. elegans...
- Sex-determining genes on mouse autosomes identified by linkage analysis of C57BL/6J-YPOS sex reversalE M Eicher
Jackson Laboratory, Bar Harbor, Maine 04609, USA
Nat Genet 14:206-9. 1996..The TDA proteins may regulate Sry expression or form complexes with the SRY protein to regulate other genes, or the tda genes may be activated or repressed by the SRY protein...
- The genetic and molecular analysis of spe-19, a gene required for sperm activation in Caenorhabditis elegansBrian Geldziler
Waksman Institute, Department of Genetics, Rutgers University, Piscataway, NJ 08854, USA
Dev Biol 283:424-36. 2005....
- Surveys of plasma vitellogenin and intersex in male flounder (Platichthys flesus) as measures of endocrine disruption by estrogenic contamination in United Kingdom estuaries: temporal trends, 1996 to 2001Mark F Kirby
Centre for Environment, Fisheries and Aquaculture Science Burnham Laboratory, Remembrance Avenue, Burnham on Crouch, Essex CM0 8HA, United Kingdom
Environ Toxicol Chem 23:748-58. 2004..The significance of the findings and possible mitigating influences are discussed in terms of the impacts on wild fish and the role of effluent treatment in reducing these...
- glp-1 is required in the germ line for regulation of the decision between mitosis and meiosis in C. elegansJ Austin
Laboratory of Cell and Molecular Biology, Graduate School University of Wisconsin, Madison 53706
Cell 51:589-99. 1987..Mosaic analyses suggest that glp-1 is produced in the germ line. We propose that glp-1 acts as part of the receiving mechanism in the interaction between the distal tip cell and germ line...
- Phylogeny of the nematode genus Pristionchus and implications for biodiversity, biogeography and the evolution of hermaphroditismWerner E Mayer
Max Planck Institute for Developmental Biology, Department of Evolutionary Biology, Tubingen, Germany
BMC Evol Biol 7:104. 2007..Evolutionary interpretations of differences in developmental, behavioral and ecological patterns require a phylogenetic framework of the genus Pristionchus...
- Response of larval Xenopus laevis to atrazine: assessment of growth, metamorphosis, and gonadal and laryngeal morphologyJames A Carr
Department of Biological Sciences, Texas Tech University, Lubbock, Texas 79409, USA
Environ Toxicol Chem 22:396-405. 2003..laevis. The incidence of atrazine-induced intersex animals was small (<5%) and occurred only at the greatest concentration of atrazine tested, a concentration that is rarely observed in surface waters in the United States...
- Persistence of Mhc heterozygosity in homozygous clonal killifish, Rivulus marmoratus: implications for the origin of hermaphroditismAkie Sato
Max Planck Institut fur Biologie, Abteilung Immungenetik, 72076 Tubingen, Germany
Genetics 162:1791-803. 2002..To shed light on its population structure and the origin of hermaphroditism, major histocompatibility complex (Mhc) class I genes of the killifish from seven different localities in ..
- The impact of oestrogenic and androgenic contamination on marine organisms in the United Kingdom--summary of the EDMAR programme. Endocrine Disruption in the Marine EnvironmentPeter Matthiessen
Centre for Ecology and Hydrology, Ambleside, Cumbria, UK
Mar Environ Res 54:645-9. 2002..The majority of the oestrogenic activity is adsorbed to sediments, and routes of exposure may include benthic food chain transfer. Some natural androgenic substances are also being discharged to estuaries, but their activity appears low...
- The sensory circuitry for sexual attraction in C. elegans malesJamie Q White
Howard Hughes Medical Institute, University of Utah, 257 South 1400 East, Salt Lake City, Utah 84112 0840, USA
Curr Biol 17:1847-57. 2007..Are the behavioral differences due to sex-specific or core neurons?..
- On the potential for extinction by Muller's ratchet in Caenorhabditis elegansLaurence Loewe
Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JT, UK
BMC Evol Biol 8:125. 2008..The potential for such a process to occur would inform our understanding of the time since the origin of self-fertilization in C. elegans history...
- Sexual selection and maintenance of sex: evidence from comparisons of rates of genomic accumulation of mutations and divergence of sex-related genes in sexual and hermaphroditic species of CaenorhabditisCarlo G Artieri
Department of Biology, McMaster University, Hamilton, Ontario, Canada
Mol Biol Evol 25:972-9. 2008..Here, we examine the advantages of dioecy versus hermaphroditism by comparing the rate of evolution in sex-related genes and the rate of accumulation of deleterious mutations ..
- Intersex in feral marine and freshwater fish from northeastern GermanyJens Gercken
Institute of Applied Ecology, Rostock Neu Broderstorf, Germany
Mar Environ Res 54:651-5. 2002..The findings suggest that feminised male fish were exposed to endocrine disrupting substances in the aquatic environment...
- Atrazine-induced hermaphroditism at 0.1 ppb in American leopard frogs (Rana pipiens): laboratory and field evidenceTyrone Hayes
Laboratory for Integrative Studies in Amphibian Biology, Group in Endocrinology, Museum of Vertebrate Zoology, and Department of Integrative Biology, University of California, Berkeley, California 94720, USA
Environ Health Perspect 111:568-75. 2003..1 ppb) resulted in retarded gonadal development (gonadal dysgenesis) and testicular oogenesis (hermaphroditism) in leopard frogs (Rana pipiens). Slower developing males even experienced oocyte growth (vitellogenesis)...
- Inbreeding and outbreeding depression in Caenorhabditis nematodesElie S Dolgin
Institute of Evolutionary Biology, University of Edinburgh, King s Buildings, Edinburgh, UK
Evolution 61:1339-52. 2007..elegans performed better than crosses between strains, indicating outbreeding depression. The results are discussed in relation to the evolution of androdioecy and the effect of mating system on the level of inbreeding depression...
- Distinct patterns of genetic variation in Pristionchus pacificus and Caenorhabditis elegans, two partially selfing nematodes with cosmopolitan distributionHans Zauner
Max Planck Institute for Developmental Biology, Department of Evolutionary Biology, 72076 Tubingen, Germany
Mol Ecol 16:1267-80. 2007b>Hermaphroditism has evolved several times independently in nematodes. The model organism Caenorhabditis elegans and Pristionchus pacificus are self-fertile hermaphrodites with rare facultative males...
- Nematodes of the genus Pristionchus are closely associated with scarab beetles and the Colorado potato beetle in Western EuropeMatthias Herrmann
Max Planck Institute for Developmental Biology, Department of Evolutionary Biology, Spemannstrasse 37 39, D 72076 Tubingen, Germany
Zoology (Jena) 109:96-108. 2006..We describe the initial evidence for the association of Pristionchus nematodes with beetles and provide a phylogeny based on sequence analysis of the small subunit ribosomal RNA gene...
- Mutation and the experimental evolution of outcrossing in Caenorhabditis elegansA D Cutter
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ, USA
J Evol Biol 18:27-34. 2005..This provides experimental evidence consistent with deleterious mutational explanations for the evolution of sex in principle, but the action of other processes is required to explain the evolution of sex in entirety...
- Caenorhabditis elegans germline patterning requires coordinated development of the somatic gonadal sheath and the germ lineDarrell J Killian
Department of Biology, New York University, 100 Washington Square East, New York, NY 10003, USA
Dev Biol 279:322-35. 2005..Our study underscores the importance of strict developmental coordination between neighboring tissues. We discuss these results in the context of mechanisms that may underlie tumorigenesis...
- Levels of inbreeding depression over seven generations of selfing in the androdioecious clam shrimp, Eulimnadia texanaS C Weeks
Department of Biology, The University of Akron, OH, USA
J Evol Biol 17:475-84. 2004..Therefore, delta in this species is likely due to associative overdominance caused by deleterious recessive alleles linked to the sex determining locus...
- Gender identity outcome in female-raised 46,XY persons with penile agenesis, cloacal exstrophy of the bladder, or penile ablationHeino F L Meyer-Bahlburg
New York State Psychiatric Institute, New York, NY 10032, USA
Arch Sex Behav 34:423-38. 2005....
- Redundant control of the Caenorhabditis elegans sperm/oocyte switch by PUF-8 and FBF-1, two distinct PUF RNA-binding proteinsJennifer L Bachorik
Program in Cellular and Molecular Biology, Department of Biochemistry, and Howard Hughes Medical Institute, University of Wisconsin, Madison, WI 53706, USA
Proc Natl Acad Sci U S A 102:10893-7. 2005..We suggest that PUF-8 and FBF-1 may control fog-2 expression, and that the sperm/oocyte decision occurs in the distal germ line...
- Sex determination: ways to evolve a hermaphroditeChristian Braendle
Institut Jacques Monod, CNRS Universités Paris 6 and 7, Tour 43, 2 place Jussieu, 75251 Paris Cedex 05, France
Curr Biol 16:R468-71. 2006..elegans and C. briggsae, however, produce self-fertile hermaphrodites instead of females. These transitions to hermaphroditism evolved convergently through distinct modifications of germline sex determination mechanisms.
- Precopulatory stabbing, hypodermic injections and unilateral copulations in a hermaphroditic sea slugNils Anthes
Animal Evolutionary Ecology, Zoological Institute, University of Tubingen, Auf der Morgenstelle 28, 72076 Tubingen, Germany
Biol Lett 3:121-4. 2007..quadrispinosum represents conflicting rather than complementary mating interests between mates...
- A C. elegans sperm TRP protein required for sperm-egg interactions during fertilizationX Z Shawn Xu
Howard Hughes Medical Institute and Division of Biology, California Institute of Technology, Pasadena, CA 91125 USA
Cell 114:285-97. 2003..As C. elegans oocytes lack egg coats, our data suggest that some TRPC family channels might function to mediate calcium influx during sperm-egg plasma membrane interactions leading to fertilization...
- The proximate determinants of sex ratio in C. elegans populationsAsher D Cutter
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
Genet Res 81:91-102. 2003..Finally, we discuss the short-term and long-term factors that are likely to affect sex ratio and breeding system evolution in species like C. elegans...
- Androgen imprinting of the brain in animal models and humans with intersex disorders: review and recommendationsZoltan Hrabovszky
Surgical Department, Royal Children s Hospital, Melbourne, Victoria, Australia
J Urol 168:2142-8. 2002..We reviewed the evidence in animal and human studies to determine the possible role of early postnatal androgen production in gender development...
- Evolution of sperm size in nematodes: sperm competition favours larger spermC W LaMunyon
Department of Molecular and Cellular Biology, University of Arizona, Tucson 85721, USA
Proc Biol Sci 266:263-7. 1999..Larger sperm have thus evolved in species with a greater risk of sperm competition. Our results support recent studies contending that sperm size may increase in response to sperm competition...
- True hermaphroditism in a 46,XY individual, caused by a postzygotic somatic point mutation in the male gonadal sex-determining locus (SRY): molecular genetics and histological findings in a sporadic caseA Braun
Institute of Anthropology and Human Genetics, Children s Hospital, University of Munich, Germany
Am J Hum Genet 52:578-85. 1993..The origin of the patient's intersexuality is a postzygotic mutation of the SRY occurring in part of the gonadal tissue. This event caused the loss of the testis-determining function in affected cells...
- Why are there males in the hermaphroditic species Caenorhabditis elegans?J R Chasnov
Department of Mathematics, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
Genetics 160:983-94. 2002..elegans can support male-specific genes against mutational degeneration. This results in the continuing presence of functional males in a 99.9% hermaphroditic species in which outcrossing is disadvantageous to hermaphrodites...
- Hermaphroditic, demasculinized frogs after exposure to the herbicide atrazine at low ecologically relevant dosesTyrone B Hayes
Laboratory for Integrative Studies in Amphibian Biology, Group in Endocrinology, Museum of Vertebrate Zoology, Department of Integrative Biology, University of California, Berkeley, CA 94720 3140, USA
Proc Natl Acad Sci U S A 99:5476-80. 2002..Atrazine (> or =0.1 ppb) induced hermaphroditism and demasculinized the larynges of exposed males (> or =1.0 ppb)...
- Suppressors of a lin-12 hypomorph define genes that interact with both lin-12 and glp-1 in Caenorhabditis elegansM Sundaram
Department of Molecular Biology, Princeton University, New Jersey 08544
Genetics 135:765-83. 1993..These sel genes may therefore function in both lin-12 and glp-1 mediated cell fate decisions...
- Larger sperm outcompete smaller sperm in the nematode Caenorhabditis elegansC W LaMunyon
Department of Molecular and Cellular Biology, University of Arizona, Tucson 85741, USA
Proc Biol Sci 265:1997-2002. 1998..Our results provide evidence of a mechanism to support recent theoretical and comparative studies that suggest sperm competition can favour not small, but large sperm...
- A reliable endocrine test with human menopausal gonadotropins for diagnosis of true hermaphroditism in early infancyJ P Mendez
Research Unit in Developmental Biology, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico, DF, Mexico
J Clin Endocrinol Metab 83:3523-6. 1998In true hermaphroditism diverse phenotypes and karyotypes are found; there are no distinctive laboratory features that can distinguish it from other intersex disorders, thus the diagnosis is made by the histological findings...
- RNA and sex determination in Caenorhabditis elegans. Post-transcriptional regulation of the sex-determining tra-2 and fem-3 mRNAs in the Caenorhabditis elegans hermaphroditeA Puoti
Department of Biology, University of Fribourg, Rue du Musée 10, 1700 Fribourg, Switzerland
EMBO Rep 2:899-904. 2001....
- Increased competitiveness of nematode sperm bearing the male X chromosomeC W LaMunyon
Department of Molecular and Cellular Biology, University of Arizona, Tucson 85721, USA
Proc Natl Acad Sci U S A 94:185-9. 1997..Thus, the multiple levels of sperm competitiveness found in C. briggsae maximize outcrossing after mating while delaying the cost of making male offspring...
- Evolution of the PP2C family in Caenorhabditis: rapid divergence of the sex-determining protein FEM-2Paul Stothard
Department of Biological Sciences, University of Alberta, Edmonton, Canada
J Mol Evol 54:267-82. 2002..fem-2 (RNAi) in C. elegans and C. briggsae caused germ-line feminization, but had no noticeable effect in CB5161. Thus the function of fem-2 in CB5161 remains uncertain...
- Sex-dependent resistance to the pathogenic fungus Cryptococcus neoformansMaaike C W van den Berg
Department of Molecular Pathobiology, University of Birmingham, UK
Genetics 173:677-83. 2006..Our results hint at an overlap between the pathways controlling immunity and longevity and raise the possibility that differential regulation of these pathways may contribute to sex-dependent and species-dependent variation...
- Evidence of a high percentage of intersex in the Mediterranean swordfish (Xiphias gladius L.)G De Metrio
Department of Animal Health and Welfare, University of Bari, s p per Casamassima km 3, I 70010 Valenzano BA, Italy
Mar Pollut Bull 46:358-61. 2003..The presence of vitellogenin was demonstrated immunohistochemically in the liver of both intersex and normal males. These findings could be due to the exposure to oestrogen-mimicking substances...
- Alterations in ribosome biogenesis cause specific defects in C. elegans hermaphrodite gonadogenesisRoumen Voutev
Department of Biology, New York University, New York, NY 10003 6688, USA
Dev Biol 298:45-58. 2006..We conclude that the C. elegans distal sheath is particularly sensitive to alterations in ribosome biogenesis and that ribosome biogenesis defects in one tissue can non-autonomously influence proliferation in an adjacent tissue...
- The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9B Conradt
Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
Cell 93:519-29. 1998..We propose that EGL-1 activates programmed cell death by binding to and directly inhibiting the activity of CED-9, perhaps by releasing the cell death activator CED-4 from a CED-9/CED-4-containing protein complex...
- lin-1 has both positive and negative functions in specifying multiple cell fates induced by Ras/MAP kinase signaling in C. elegansTeresa Tiensuu
Umeå Center for Molecular Pathogenesis, Umea University, SE 901 87 Umea, Sweden
Dev Biol 286:338-51. 2005..We also show that lin-1 apparently has both positive and negative functions during the specification of the fates of other cells in the worm requiring Ras/MAP kinase signaling...
- C. elegans EVI1 proto-oncogene, EGL-43, is necessary for Notch-mediated cell fate specification and regulates cell invasionByung Joon Hwang
Howard Hughes Medical Institute and Division of Biology, 156 29, California Institute of Technology, Pasadena, CA 91125, USA
Development 134:669-79. 2007..Thus, egl-43 integrates temporally distinct upstream regulatory events and helps program cell fate specification and cell invasion...
- Expression of ram-5 in the structural cell is required for sensory ray morphogenesis in Caenorhabditis elegans male tailR Y Yu
Department of Biology, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
EMBO J 19:3542-55. 2000..ram-5-dependent cell-cell communication is implicated in organizing the structural cell and the hypodermis, potentially through adhesion at the structural cell-hypodermal cell border...
- Genome-wide analysis of sex-enriched gene expression during C. elegans larval developmentKara Thoemke
Department of Genetics, Cell Biology, and Development, and Developmental Biology Center, University of Minnesota, Minneapolis, MN 55455, USA
Dev Biol 284:500-8. 2005..These results suggest that TRA-1 controls sexual dimorphism through a small number of intermediary regulators rather than by acting directly on the full constellation of genes involved in sex-specific differentiation...
- SDC-3 coordinates the assembly of a dosage compensation complex on the nematode X chromosomeT L Davis
Department of Molecular and Cell Biology, University of California, Berkeley 94720 3204, USA
Development 124:1019-31. 1997..Our experiments suggest the possible involvement of zinc finger motifs in X chromosome recognition and the amino-terminal region in interactions with other dosage compensation proteins...
- The C. elegans gene lin-9,which acts in an Rb-related pathway, is required for gonadal sheath cell development and encodes a novel proteinG J Beitel
Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Gene 254:253-63. 2000..We suggest that lin-9 is the founding member of a new protein family that functions in Rb-related pathways in many species...
- Embryonic morphogenesis in Caenorhabditis elegans integrates the activity of LET-502 Rho-binding kinase, MEL-11 myosin phosphatase, DAF-2 insulin receptor and FEM-2 PP2c phosphataseA J Piekny
Genes and Development Research Group and Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta T2N 4N1, Canada
Genetics 156:1671-89. 2000..fem-2 blocked the near-normal elongation of let-502; mel-11 indicating that fem-2 acts in a parallel elongation pathway. The action of two redundant pathways likely ensures accurate elongation of the C. elegans embryo...
- gon-4, a cell lineage regulator required for gonadogenesis in Caenorhabditis elegansL Friedman
Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
Dev Biol 228:350-62. 2000..We conclude that gon-4 is a regulator of the early lineage of Z1 and Z4 and suggest that it is a part of a genetic program common to the regulation of both hermaphrodite and male gonadogenesis...
- Reproduction and longevity: secrets revealed by C. elegansArnab Mukhopadhyay
Program in Gene Function and Expression, Program in Molecular Medicine, University of Massachusetts Medical School 364 Plantation Street, Worcester, MA 01605, USA
Trends Cell Biol 17:65-71. 2007..Here we discuss recent advances in our understanding of the regulation of life span by reproductive signaling, focusing on studies using Caenorhabditis elegans...
- Chromosome sites play dual roles to establish homologous synapsis during meiosis in C. elegansAmy J MacQueen
Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
Cell 123:1037-50. 2005..We speculate that concentration of these activities at one region per chromosome may have coevolved with the loss of a point centromere to safeguard karyotype stability...
- Single Centriole-Mediated Gynogenesis in the ZebrafishFrancisco J Pelegri; Fiscal Year: 2012..This potentially provides to the zebrafish model a power similar to that of the hermaphroditism-based C. elegans genetics...
- The genetics of gamete sex control in convergent Caenorhabditis hermaphroditesJOSEPH ANDREW ROSS; Fiscal Year: 2011..but different genetic alterations of the pathway independently produced the same sexual developmental trait, hermaphroditism, in both species...
- GONADAL AND PHENOTYPIC SEX DIFFERENTIATIONFREDRICK GEORGE; Fiscal Year: 1993..It is hoped that these studies will provide clues to disorders (such as true hermaphroditism, the XX male, pure gonadal dysgenesis, the vanishing testis, etc...
- STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF WT1J Joung; Fiscal Year: 2004..efficiency of the +KTS splicing event have been associated with Frasier syndrome characterized by male pseudo-hermaphroditism, progressive glomerulonephropathy with chronic renal failure, and an increased risk of gonadoblastoma...
- ATRAZINE: IMPACT ON ENVIRONMENTAL AND PUBLIC HEALTHTyrone Hayes; Fiscal Year: 2004..induction of aromatase, has now been identified in amphibians, fish, and reptiles, and is consistent with the hermaphroditism observed in wildlife exposed to atrazine in the laboratory and field...
- Molecular Genetics of HemicentinBruce Vogel; Fiscal Year: 2006....
- Gamete Interactions in Caenorhabditis elegansAndrew Singson; Fiscal Year: 2007..This work will complement fertility studies in other organisms as well as provide insights into the mechanisms of cell-cell interactions and the diversity of reproductive strategies. [unreadable] [unreadable] [unreadable]..
- Regulation and Function of Hox gene lin-39 in C elegansDAVID EISENMANN; Fiscal Year: 2007..elegans, for which full genomic sequence is available and functional genomic approaches are available. ..
- Gamete Interactions in Caenorhabditis elegansAndrew Singson; Fiscal Year: 2005..This work will provide new insight into cell-cell interactions, conception and complement studies of fertilization in other organisms. ..
- GENDER IDENTITY--SEX REASSIGNMENT DUE TO GENITAL DEFECTSWilliam Reiner; Fiscal Year: 2003..The results of these studies should lead to more rational, research-informed, surgical and psychiatric approaches to these children and their families. ..
- AUTOSOMAL MECHANISMS OF TESTIS INDUCTIONVICKI MEYERS WALLEN; Fiscal Year: 2005..At the end of this grant period, we will have identified the gene causing this disorder and the step in the testis pathway that is altered by the mutation in timing, quantity, or location of gene expression. ..
- MAP kinase signal specificity in the C. elegans germlineValerie Reinke; Fiscal Year: 2007..Together these experiments should build toward a comprehensive understanding of the mechanisms used to produce a specific cell fate in response to a generally used signaling pathway. ..
- The Genetics of Dauer LongevityPHILIP HARTMAN; Fiscal Year: 2003..Collectively these experiments should provide a foundational basis for future, more systematic examinations of dauer longevity. ..
- The molecular basis for an animal model of inherited hyperuricosuriaDanika Bannasch; Fiscal Year: 2007..The elucidation of a novel gene function should provide new avenues of investigation for the treatment of the human condition. [unreadable] [unreadable] [unreadable]..
- GENETIC CONTROL OF MEIOTIC CHROMOSOME SEGREGATIONPatricia Hunt; Fiscal Year: 2009..The combined data from these studies will allow us to understand the control of recombination In mammals and how the events of prophase influence meiotic chromosome segregation. ..
- Genetic Regulation of Mating Behavior in C. elegan MalesLuis Garcia; Fiscal Year: 2009..Additionally, this project will identify components of activating pathways that must be attenuated by unc-103 during periods between mating. ..
- Conference on Mammalian Gametogenesis & EmbryogenesisPatricia Hunt; Fiscal Year: 2002..A particularly important aspect of the Gordon Conference setting is the blending of young and established investigators to promote exchanges that will generate new ideas and foster new collaborations in the field. ..
- The Mouse Oocyte: A New Assay for Reproductive ToxinsPatricia Hunt; Fiscal Year: 2003..In addition, because the observed meiotic disruption (congression failure) is an age-related defect in human oocytes, the data may provide important insight to human age-related aneuploidy. ..