hermaphroditism

Summary

Summary: A state of intersex or sexual ambiguity, involving the GENOTYPE, the GONADS, the reproductive tract, and/or the external GENITALIA or PHENOTYPE. This concept covers TRUE HERMAPHRODITISM and PSEUDOHERMAPHRODITISM. True hermaphrodites are rare and they possess gonadal tissues of both SEXES, tissues from the OVARY and the TESTIS. Pseudohermaphrodites possess gonadal tissue of one sex but exhibit external phenotype of the opposite sex.

Top Publications

  1. pmc Evidence of a mate-finding cue in the hermaphrodite nematode Caenorhabditis elegans
    Jasper M Simon
    Division of Biology and Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 99:1598-603. 2002
  2. pmc Temporal dynamics and linkage disequilibrium in natural Caenorhabditis elegans populations
    Antoine Barrière
    Institut Jacques Monod, CNRS Universities of Paris 6 and 7, 75251 Paris Cedex 05, France
    Genetics 176:999-1011. 2007
  3. ncbi Altered sexual maturation and gamete production in wild roach (Rutilus rutilus) living in rivers that receive treated sewage effluents
    S Jobling
    Department of Biological Sciences, Brunel University, Uxbridge, Middlesex UB8 3PH, United Kingdom
    Biol Reprod 66:272-81. 2002
  4. pmc Selection and maintenance of androdioecy in Caenorhabditis elegans
    Andrew D Stewart
    Department of Biology, University of Texas, Arlington, Texas 76019 0498, USA
    Genetics 160:975-82. 2002
  5. pmc A CUL-2 ubiquitin ligase containing three FEM proteins degrades TRA-1 to regulate C. elegans sex determination
    Natalia G Starostina
    Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA
    Dev Cell 13:127-39. 2007
  6. ncbi Transgenic zebrafish with fluorescent germ cell: a useful tool to visualize germ cell proliferation and juvenile hermaphroditism in vivo
    Chung Der Hsiao
    Institute of Molecular and Cell Biology, and Institute of Fisheries Science, National Taiwan University, 1 Roosevelt Road, Section 4, 106, Taipei, Taiwan
    Dev Biol 262:313-23. 2003
  7. ncbi Anticonvulsant medications extend worm life-span
    Kimberley Evason
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 307:258-62. 2005
  8. pmc Diversity in mating behavior of hermaphroditic and male-female Caenorhabditis nematodes
    L Rene Garcia
    Department of Biology, Texas A and M University, College Station, Texas 77843 3258, USA
    Genetics 175:1761-71. 2007
  9. pmc Caenorhabditis phylogeny predicts convergence of hermaphroditism and extensive intron loss
    Karin Kiontke
    Department of Biology, New York University, 100 Washington Square East, New York, NY 10003, USA
    Proc Natl Acad Sci U S A 101:9003-8. 2004
  10. pmc fog-2 and the evolution of self-fertile hermaphroditism in Caenorhabditis
    Sudhir Nayak
    Department of Genetics, Washington University School of Medicine St Louis, Missouri, USA
    PLoS Biol 3:e6. 2005

Research Grants

Detail Information

Publications217 found, 100 shown here

  1. pmc Evidence of a mate-finding cue in the hermaphrodite nematode Caenorhabditis elegans
    Jasper M Simon
    Division of Biology and Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 99:1598-603. 2002
    ..Finally, that males from multiple isolates of C. elegans also respond similarly to this cue indicates that this cue is robust and has been maintained during recent evolution...
  2. pmc Temporal dynamics and linkage disequilibrium in natural Caenorhabditis elegans populations
    Antoine Barrière
    Institut Jacques Monod, CNRS Universities of Paris 6 and 7, 75251 Paris Cedex 05, France
    Genetics 176:999-1011. 2007
    ..C. elegans seems to follow metapopulation dynamics, and the maintenance of linkage disequilibrium despite a low yet significant level of outcrossing suggests that selection may act against the progeny of outcrossings...
  3. ncbi Altered sexual maturation and gamete production in wild roach (Rutilus rutilus) living in rivers that receive treated sewage effluents
    S Jobling
    Department of Biological Sciences, Brunel University, Uxbridge, Middlesex UB8 3PH, United Kingdom
    Biol Reprod 66:272-81. 2002
    ....
  4. pmc Selection and maintenance of androdioecy in Caenorhabditis elegans
    Andrew D Stewart
    Department of Biology, University of Texas, Arlington, Texas 76019 0498, USA
    Genetics 160:975-82. 2002
    ..Factors such as variation in male mating ability and inbreeding depression could potentially lead to the long-term maintenance of males...
  5. pmc A CUL-2 ubiquitin ligase containing three FEM proteins degrades TRA-1 to regulate C. elegans sex determination
    Natalia G Starostina
    Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA
    Dev Cell 13:127-39. 2007
    ..This work demonstrates that the terminal step in C. elegans sex determination is controlled by ubiquitin-mediated proteolysis...
  6. ncbi Transgenic zebrafish with fluorescent germ cell: a useful tool to visualize germ cell proliferation and juvenile hermaphroditism in vivo
    Chung Der Hsiao
    Institute of Molecular and Cell Biology, and Institute of Fisheries Science, National Taiwan University, 1 Roosevelt Road, Section 4, 106, Taipei, Taiwan
    Dev Biol 262:313-23. 2003
    ..In order to fully capture the dynamic processes of germ cells' proliferation and juvenile hermaphroditism in zebrafish, we established transgenic lines TG(beta-actin:EGFP), harboring an enhanced green fluorescent ..
  7. ncbi Anticonvulsant medications extend worm life-span
    Kimberley Evason
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 307:258-62. 2005
    ..These findings suggest that the life-span-extending activity of these compounds is related to the anticonvulsant activity and implicate neural activity in the regulation of aging...
  8. pmc Diversity in mating behavior of hermaphroditic and male-female Caenorhabditis nematodes
    L Rene Garcia
    Department of Biology, Texas A and M University, College Station, Texas 77843 3258, USA
    Genetics 175:1761-71. 2007
    ....
  9. pmc Caenorhabditis phylogeny predicts convergence of hermaphroditism and extensive intron loss
    Karin Kiontke
    Department of Biology, New York University, 100 Washington Square East, New York, NY 10003, USA
    Proc Natl Acad Sci U S A 101:9003-8. 2004
    ..a well resolved phylogeny that reveals three striking patterns in the evolution of this animal group: (i) Hermaphroditism has evolved independently in C...
  10. pmc fog-2 and the evolution of self-fertile hermaphroditism in Caenorhabditis
    Sudhir Nayak
    Department of Genetics, Washington University School of Medicine St Louis, Missouri, USA
    PLoS Biol 3:e6. 2005
    ..briggsae, providing functional evidence in support of the independent evolution of self-fertile hermaphroditism. We speculate on the convergent evolution of hermaphroditism in Caenorhabditis based on the plasticity of the ..
  11. ncbi Mus poschiavinus Y chromosome in the C57BL/6J murine genome causes sex reversal
    E M Eicher
    Science 217:535-7. 1982
  12. pmc The genetics of caloric restriction in Caenorhabditis elegans
    B Lakowski
    Department of Biology, McGill University, 1205 Dr Penfield Avenue, Montreal, Quebec, Canada H3A 1B1
    Proc Natl Acad Sci U S A 95:13091-6. 1998
    ..In contrast, we find that food restriction does not further increase the life span of long-lived clk-1 mutants, suggesting that clk-1 and caloric restriction affect similar processes...
  13. ncbi Elevated serum vitellogenin levels and gonadal abnormalities in wild male flounder (Pleuronectes yokohamae) from Tokyo Bay, Japan
    S Hashimoto
    Department of Ocean Sciences, Tokyo University of Fisheries, 4 5 7 Konan, Minato ku, Tokyo 108 8477, Japan
    Mar Environ Res 49:37-53. 2000
    ..This study suggests that the abnormally high levels of VTG and the presence of oocytes in the testis of male flounder collected from Tokyo Bay could be the effect of environmental estrogens...
  14. ncbi Mate searching in Caenorhabditis elegans: a genetic model for sex drive in a simple invertebrate
    Jonathan Lipton
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 24:7427-34. 2004
    ..left food, in two cases with similar frequency, suggesting coordinate evolution of behavioral dimorphism with hermaphroditism. We use a quantitative behavioral assay to show that C...
  15. pmc X-chromosome silencing in the germline of C. elegans
    William G Kelly
    Biology Department, Emory University, Atlanta, GA 30322, USA
    Development 129:479-92. 2002
    ..Silencing of the sex chromosome during early meiosis is a conserved feature throughout the nematode phylum, and is not limited to hermaphroditic species...
  16. ncbi Regulation of sperm activation by SWM-1 is required for reproductive success of C. elegans males
    Gillian M Stanfield
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Curr Biol 16:252-63. 2006
    ..In nematodes, spermiogenesis, or sperm activation, involves a rapid cellular morphogenesis that converts unpolarized round spermatids into polarized amoeboid spermatozoa capable of both motility and fertilization...
  17. pmc A blend of small molecules regulates both mating and development in Caenorhabditis elegans
    Jagan Srinivasan
    Howard Hughes Medical Institute and Biology Division, California Institute of Technology, 1200 E California Boulevard, Pasadena, California 91125, USA
    Nature 454:1115-8. 2008
    ..The ascaroside signalling system thus connects reproductive and developmental pathways and represents a unique example of structure- and concentration-dependent differential activity of signalling molecules...
  18. ncbi A genetic pathway for the development of the Caenorhabditis elegans HSN motor neurons
    C Desai
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    Nature 336:638-46. 1988
    ..Nearly all are pleiotropic, revealing that the genes specifying HSN development also function in the development of other cell types...
  19. ncbi Genome-wide germline-enriched and sex-biased expression profiles in Caenorhabditis elegans
    Valerie Reinke
    Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
    Development 131:311-23. 2004
    ..Comparison with data from large-scale RNAi screens demonstrates that genes expressed in the oogenic germline display visible phenotypes more frequently than expected...
  20. ncbi FOG-2, a novel F-box containing protein, associates with the GLD-1 RNA binding protein and directs male sex determination in the C. elegans hermaphrodite germline
    R Clifford
    Department of Genetics, Washington University School of Medicine, Campus Box 8232, St Louis, MO 63110, USA
    Development 127:5265-76. 2000
    ..fog-2 may have arisen during evolution of self-fertile hermaphroditism from an ancestral female/male species.
  21. ncbi A sperm cytoskeletal protein that signals oocyte meiotic maturation and ovulation
    M A Miller
    Department of Cell Biology, Mass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Science 291:2144-7. 2001
    ..Proteins with MSP-like domains are found in plants, fungi, and other animals, suggesting that related signaling functions may exist in other phyla...
  22. ncbi Effects of endocrine disruptors on prosobranch snails (Mollusca: Gastropoda) in the laboratory. Part III: Cyproterone acetate and vinclozolin as antiandrogens
    M Tillmann
    Internationales Hochschulinstitut Zittau, Lehrstuhl Umweltverfahrenstechnik, Fachgruppe Human- und Okotoxikologie, Markt 23, D-02763 Zittau, Germany
    Ecotoxicology 10:373-88. 2001
    ..Compared with estrogens and androgens, the antiandrogen responses seem to be less drastic and might have--in contrast to the two other disruptor classes--no biologically significant effects at the population level...
  23. ncbi Genetic flexibility in the convergent evolution of hermaphroditism in Caenorhabditis nematodes
    Robin Cook Hill
    Department of Biology, University of Maryland, College Park, 20742, USA
    Dev Cell 10:531-8. 2006
    ..These findings are consistent with convergent evolution of hermaphroditism, which is marked by considerable developmental genetic flexibility.
  24. ncbi Changes in the reproductive system of the snail Helix aspersa caused by mucus from the love dart
    J M Koene
    Department of Biology, McGill University, Montreal Quebec, H3A 1B1 Canada
    J Exp Biol 201:2313-9. 1998
    ..By influencing the female organs involved in the processing of foreign sperm, the dart shooter may increase the chance that his sperm will fertilise eggs...
  25. pmc Molecular evolution in Panagrolaimus nematodes: origins of parthenogenesis, hermaphroditism and the Antarctic species P. davidi
    Samantha C Lewis
    Department of Zoology and Center for Genome Research and Biocomputing, Oregon State University, Corvallis, Oregon 97331, USA
    BMC Evol Biol 9:15. 2009
    ..The evolutionary origins of these varying reproductive modes and the Antarctic species P. davidi, however, remain enigmatic...
  26. ncbi Parasites and the evolution of self-fertilization
    A F Agrawal
    Department of Biology, Indiana University, Bloomington 47405 3700, USA
    Evolution 55:869-79. 2001
    ..In addition, mixed mating, where it exits, tends to be biased toward selfing...
  27. ncbi Alterations to gonadal development and reproductive success in Japanese medaka (Oryzias latipes) exposed to 17alpha-ethinylestradiol
    Gordon C Balch
    Environmental and Resource Studies Program, Trent University, Peterborough, Ontario K9J 7B8, Canada
    Environ Toxicol Chem 23:782-91. 2004
    ..However, it is clear that concentrations of endocrine disrupting chemicals (EDCs) that cause gonadal intersex are sufficient to reduce reproductive performance...
  28. ncbi First observation of intersex cyprinids in the Po River (Italy)
    L Vigano
    Istituto di Ricerca Sulle Acque, CNR, Brugherio Milan, Italy
    Sci Total Environ 269:189-94. 2001
    ..In fact, 50% of the barbel captured (8 of 16 fish) in the downstream reach showed intersex gonads...
  29. ncbi Management of the African child with true hermaphroditism
    R Wiersma
    Department of Paediatric Surgery, University of Natal, Durban, South Africa
    J Pediatr Surg 36:397-9. 2001
    BACKGROUND/PURPOSE: A disproportionally high incidence of true hermaphroditism is seen among the South African black people, constituting 51% of children in local study on all intersex types...
  30. ncbi Limited effectiveness of marine protected areas: imposex in Hexaplex trunculus (Gastropoda, Muricidae) populations from Italian marine reserves
    A Terlizzi
    Laboratory of Zoology and Marine Biology, Department of Biological and Environmental Science and Technology, University of Lecce, CoNISMa, Strada Prov le Monteroni, Lecce 73100, Italy
    Mar Pollut Bull 48:188-92. 2004
  31. ncbi Mechanisms of imposex induction in the mud snail, Ilyanassa obsoleta: TBT as a neurotoxin and aromatase inhibitor
    Eva Oberdörster
    Southern Methodist University, Dallas, TX 75275 0376, USA
    Mar Environ Res 54:715-8. 2002
    ..Although the role of vertebrate sex steroids is not known in gastropods, it is possible that the combination of changes in peptide and steroid hormones may lead to imposex induction at extremely low doses of TBT...
  32. pmc Widespread genetic incompatibility in C. elegans maintained by balancing selection
    Hannah S Seidel
    Lewis Sigler Institute for Integrative Genomics and Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA
    Science 319:589-94. 2008
    ..Our data suggest that long-term maintenance of a balanced polymorphism has permitted the incompatibility to persist despite gene flow across the rest of the genome...
  33. pmc Endocrine disruption and altered gonadal development in white perch (Morone americana) from the lower Great Lakes region
    Richard J Kavanagh
    Environmental and Resource Studies, Trent University, 1600 West Bank Drive, Peterborough, Ontario K9J 7B8, Canada
    Environ Health Perspect 112:898-902. 2004
    ..These observations indicate that male white perch are exposed to estrogenic endocrine-disrupting substances that may be responsible for the induction of gonadal intersex...
  34. ncbi A cytogenetic investigation of inherited true hermaphroditism in BALB/cWt mice
    E M Eicher
    Cytogenet Cell Genet 28:104-15. 1980
    A predictably high incidence of true hermaphroditism (3%) among fetal BALB/cWt mice provided the opportunity for studying the cause of inherited hermaphroditism...
  35. ncbi Molecular analysis in true hermaphroditism: demonstration of low-level hidden mosaicism for Y-derived sequences in 46,XX cases
    Gloria Queipo
    Hospital General de Mexico Facultad de Medicina, UNAM, Dr Balmis 148 Col Doctores CP 06726, Mexico City, Mexico
    Hum Genet 111:278-83. 2002
    True hermaphroditism (TH) is an unusual form of sex reversal, characterized by the development of testicular and ovarian tissue in the same subject...
  36. pmc gld-1, a tumor suppressor gene required for oocyte development in Caenorhabditis elegans
    R Francis
    Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Genetics 139:579-606. 1995
    ..This function of gld-1 is inferred from a haplo-insufficient phenotype and from the properties of gain-of-function gld-1 mutations that cause alterations in the sexual identity of germ cells...
  37. pmc Consensus statement on management of intersex disorders
    I A Hughes
    Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital, Box 116, Level 8, Hills Road, Cambridge CB2 2QQ, UK
    Arch Dis Child 91:554-63. 2006
  38. ncbi Animals mix it up too: the distribution of self-fertilization among hermaphroditic animals
    Philippe Jarne
    Centre d Ecologie Fonctionnelle et Evolutive, Centre National de la Recherche Scientifique, 1919 Route de Mende, 34293, Montpellier 5, France
    Evolution 60:1816-24. 2006
    Excluding insects, hermaphroditism occurs in about one-third of animal species, providing numerous opportunities for the evolution of selfing...
  39. ncbi Sediments are major sinks of steroidal estrogens in two United Kingdom rivers
    Mika Peck
    University of Sussex, Department of Chemistry, Physics and Environmental Science, Falmer, Brighton BN1 9QJ, United Kingdom
    Environ Toxicol Chem 23:945-52. 2004
    ..These results suggest that riverine sediments are a major sink and a potential source of persistent estrogenic contaminants...
  40. pmc Experimental insight into the proximate causes of male persistence variation among two strains of the androdioecious Caenorhabditis elegans (Nematoda)
    Viktoria Wegewitz
    Department of Evolutionary Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    BMC Ecol 8:12. 2008
    ..In the standard laboratory wild type strain N2 males disappear rapidly from populations. This is not the case in some other wild type isolates of C. elegans, among them the Hawaiian strain CB4856...
  41. pmc Exploring the envelope. Systematic alteration in the sex-determination system of the nematode caenorhabditis elegans
    Jonathan Hodgkin
    Genetics Unit, Department of Biochemistry, University of Oxford, United Kingdom
    Genetics 162:767-80. 2002
    ..The creation of these strains demonstrates the ease with which one sex-determination system can be transformed into another...
  42. ncbi Phenotypically flexible sex allocation in a simultaneous hermaphrodite
    Verena S Brauer
    Department of Evolutionary Biology, University of Muenster, Huefferstrasse 1, 48149 Muenster, Germany
    Evolution 61:216-22. 2007
    ..We argue that phenotypically flexible sex allocation in hermaphroditic animals may help us to understand the evolution and ecology of hermaphroditism.
  43. ncbi Sexual disruption in a second species of wild cyprinid fish (the gudgeon, Gobio gobio) in United Kingdom freshwaters
    R van Aerle
    Environmental and Molecular Fish Biology, School of Biological Sciences, University of Exeter, United Kingdom
    Environ Toxicol Chem 20:2841-7. 2001
    ..Together with the findings in the roach, these data on the gudgeon confirm that sexual disruption in fish in UK rivers is not species specific...
  44. ncbi Herbicides: feminization of male frogs in the wild
    Tyrone Hayes
    Laboratory for Integrative Studies in Amphibian Biology, Museum of Vertebrate Zoology, and Department of Integrative Biology, University of California, Berkeley, California 94720 3140, USA
    Nature 419:895-6. 2002
  45. ncbi Reproductive uncertainty and the relative competitiveness of simultaneous hermaphroditism versus dioecy
    W G Wilson
    1 Department of Biology, Duke University, Durham, North Carolina 27708, USA
    Am Nat 162:220-41. 2003
    b>Hermaphroditism is typically associated with a sedentary existence, whereas dioecy is associated with mobility. This pattern is reflected within flowering plants, as dioecious species commonly possess traits that promote high dispersal...
  46. ncbi Regulation of distinct muscle behaviors controls the C. elegans male's copulatory spicules during mating
    L R Garcia
    Howard Hughes Medical Institute, Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Cell 107:777-88. 2001
    ..The male gonad then lengthens the duration of EGL-19-mediated prolonged muscle contraction. This regulation of muscle contraction provides a paradigm to explain how animals initiate, monitor, and maintain a behavioral motor program...
  47. ncbi True hermaphroditism and mixed gonadal dysgenesis in young children: a clinicopathologic study of 10 cases
    Kyu Rae Kim
    Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    Mod Pathol 15:1013-9. 2002
    True hermaphroditism (TH) refers to individuals who have both unequivocal ovarian tissue and testicular elements regardless of their karyotypes; whereas mixed gonadal dysgenesis (MGD) refers to individuals who usually have a ..
  48. ncbi Every sperm is sacred: fertilization in Caenorhabditis elegans
    A Singson
    Waksman Institute and Department of Genetics, Rutgers University, Piscataway, New Jersey, 08854, USA
    Dev Biol 230:101-9. 2001
    ..This review describes progress in the genetic and molecular dissection of fertilization in C. elegans and related studies on sperm competition...
  49. ncbi The C. elegans spe-9 gene encodes a sperm transmembrane protein that contains EGF-like repeats and is required for fertilization
    A Singson
    Department of Biology, Emory University, Atlanta, Georgia 30322, USA
    Cell 93:71-9. 1998
    ..These results suggest that SPE-9 functions in the specialized cell-cell interactions required for fertilization...
  50. ncbi Testing three models on the adaptive significance of protandric simultaneous hermaphroditism in a marine shrimp
    J Antonio Baeza
    Department of Biology, The University of Louisiana at Lafayette, Lafayette, Louisiana 70504 2451, USA
    Evolution 60:1840-50. 2006
    Protandric simultaneous hermaphroditism, as reported for shrimps in the genus Lysmata, is a sexual system in which individuals invariably reproduce as males first and later in life as simultaneous hermaphrodites. I tested three models (i...
  51. pmc Sperm competition in the absence of fertilization in Caenorhabditis elegans
    A Singson
    Department of Biology, Emory University, Atlanta, Georgia 30322, USA
    Genetics 152:201-8. 1999
    ..The sperm competition assays described in this study will be useful in further classifying the large number of currently identified mutations that alter sperm function and development in C. elegans...
  52. ncbi Sex-determining genes on mouse autosomes identified by linkage analysis of C57BL/6J-YPOS sex reversal
    E M Eicher
    Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Nat Genet 14:206-9. 1996
    ..The TDA proteins may regulate Sry expression or form complexes with the SRY protein to regulate other genes, or the tda genes may be activated or repressed by the SRY protein...
  53. ncbi The genetic and molecular analysis of spe-19, a gene required for sperm activation in Caenorhabditis elegans
    Brian Geldziler
    Waksman Institute, Department of Genetics, Rutgers University, Piscataway, NJ 08854, USA
    Dev Biol 283:424-36. 2005
    ....
  54. ncbi Surveys of plasma vitellogenin and intersex in male flounder (Platichthys flesus) as measures of endocrine disruption by estrogenic contamination in United Kingdom estuaries: temporal trends, 1996 to 2001
    Mark F Kirby
    Centre for Environment, Fisheries and Aquaculture Science Burnham Laboratory, Remembrance Avenue, Burnham on Crouch, Essex CM0 8HA, United Kingdom
    Environ Toxicol Chem 23:748-58. 2004
    ..The significance of the findings and possible mitigating influences are discussed in terms of the impacts on wild fish and the role of effluent treatment in reducing these...
  55. ncbi glp-1 is required in the germ line for regulation of the decision between mitosis and meiosis in C. elegans
    J Austin
    Laboratory of Cell and Molecular Biology, Graduate School University of Wisconsin, Madison 53706
    Cell 51:589-99. 1987
    ..Mosaic analyses suggest that glp-1 is produced in the germ line. We propose that glp-1 acts as part of the receiving mechanism in the interaction between the distal tip cell and germ line...
  56. pmc Phylogeny of the nematode genus Pristionchus and implications for biodiversity, biogeography and the evolution of hermaphroditism
    Werner E Mayer
    Max Planck Institute for Developmental Biology, Department of Evolutionary Biology, Tubingen, Germany
    BMC Evol Biol 7:104. 2007
    ..Evolutionary interpretations of differences in developmental, behavioral and ecological patterns require a phylogenetic framework of the genus Pristionchus...
  57. ncbi Response of larval Xenopus laevis to atrazine: assessment of growth, metamorphosis, and gonadal and laryngeal morphology
    James A Carr
    Department of Biological Sciences, Texas Tech University, Lubbock, Texas 79409, USA
    Environ Toxicol Chem 22:396-405. 2003
    ..laevis. The incidence of atrazine-induced intersex animals was small (<5%) and occurred only at the greatest concentration of atrazine tested, a concentration that is rarely observed in surface waters in the United States...
  58. pmc Persistence of Mhc heterozygosity in homozygous clonal killifish, Rivulus marmoratus: implications for the origin of hermaphroditism
    Akie Sato
    Max Planck Institut fur Biologie, Abteilung Immungenetik, 72076 Tubingen, Germany
    Genetics 162:1791-803. 2002
    ..To shed light on its population structure and the origin of hermaphroditism, major histocompatibility complex (Mhc) class I genes of the killifish from seven different localities in ..
  59. ncbi The impact of oestrogenic and androgenic contamination on marine organisms in the United Kingdom--summary of the EDMAR programme. Endocrine Disruption in the Marine Environment
    Peter Matthiessen
    Centre for Ecology and Hydrology, Ambleside, Cumbria, UK
    Mar Environ Res 54:645-9. 2002
    ..The majority of the oestrogenic activity is adsorbed to sediments, and routes of exposure may include benthic food chain transfer. Some natural androgenic substances are also being discharged to estuaries, but their activity appears low...
  60. ncbi The sensory circuitry for sexual attraction in C. elegans males
    Jamie Q White
    Howard Hughes Medical Institute, University of Utah, 257 South 1400 East, Salt Lake City, Utah 84112 0840, USA
    Curr Biol 17:1847-57. 2007
    ..Are the behavioral differences due to sex-specific or core neurons?..
  61. pmc On the potential for extinction by Muller's ratchet in Caenorhabditis elegans
    Laurence Loewe
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JT, UK
    BMC Evol Biol 8:125. 2008
    ..The potential for such a process to occur would inform our understanding of the time since the origin of self-fertilization in C. elegans history...
  62. ncbi Sexual selection and maintenance of sex: evidence from comparisons of rates of genomic accumulation of mutations and divergence of sex-related genes in sexual and hermaphroditic species of Caenorhabditis
    Carlo G Artieri
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    Mol Biol Evol 25:972-9. 2008
    ..Here, we examine the advantages of dioecy versus hermaphroditism by comparing the rate of evolution in sex-related genes and the rate of accumulation of deleterious mutations ..
  63. ncbi Intersex in feral marine and freshwater fish from northeastern Germany
    Jens Gercken
    Institute of Applied Ecology, Rostock Neu Broderstorf, Germany
    Mar Environ Res 54:651-5. 2002
    ..The findings suggest that feminised male fish were exposed to endocrine disrupting substances in the aquatic environment...
  64. pmc Atrazine-induced hermaphroditism at 0.1 ppb in American leopard frogs (Rana pipiens): laboratory and field evidence
    Tyrone Hayes
    Laboratory for Integrative Studies in Amphibian Biology, Group in Endocrinology, Museum of Vertebrate Zoology, and Department of Integrative Biology, University of California, Berkeley, California 94720, USA
    Environ Health Perspect 111:568-75. 2003
    ..1 ppb) resulted in retarded gonadal development (gonadal dysgenesis) and testicular oogenesis (hermaphroditism) in leopard frogs (Rana pipiens). Slower developing males even experienced oocyte growth (vitellogenesis)...
  65. ncbi Inbreeding and outbreeding depression in Caenorhabditis nematodes
    Elie S Dolgin
    Institute of Evolutionary Biology, University of Edinburgh, King s Buildings, Edinburgh, UK
    Evolution 61:1339-52. 2007
    ..elegans performed better than crosses between strains, indicating outbreeding depression. The results are discussed in relation to the evolution of androdioecy and the effect of mating system on the level of inbreeding depression...
  66. ncbi Distinct patterns of genetic variation in Pristionchus pacificus and Caenorhabditis elegans, two partially selfing nematodes with cosmopolitan distribution
    Hans Zauner
    Max Planck Institute for Developmental Biology, Department of Evolutionary Biology, 72076 Tubingen, Germany
    Mol Ecol 16:1267-80. 2007
    b>Hermaphroditism has evolved several times independently in nematodes. The model organism Caenorhabditis elegans and Pristionchus pacificus are self-fertile hermaphrodites with rare facultative males...
  67. ncbi Nematodes of the genus Pristionchus are closely associated with scarab beetles and the Colorado potato beetle in Western Europe
    Matthias Herrmann
    Max Planck Institute for Developmental Biology, Department of Evolutionary Biology, Spemannstrasse 37 39, D 72076 Tubingen, Germany
    Zoology (Jena) 109:96-108. 2006
    ..We describe the initial evidence for the association of Pristionchus nematodes with beetles and provide a phylogeny based on sequence analysis of the small subunit ribosomal RNA gene...
  68. ncbi Mutation and the experimental evolution of outcrossing in Caenorhabditis elegans
    A D Cutter
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ, USA
    J Evol Biol 18:27-34. 2005
    ..This provides experimental evidence consistent with deleterious mutational explanations for the evolution of sex in principle, but the action of other processes is required to explain the evolution of sex in entirety...
  69. ncbi Caenorhabditis elegans germline patterning requires coordinated development of the somatic gonadal sheath and the germ line
    Darrell J Killian
    Department of Biology, New York University, 100 Washington Square East, New York, NY 10003, USA
    Dev Biol 279:322-35. 2005
    ..Our study underscores the importance of strict developmental coordination between neighboring tissues. We discuss these results in the context of mechanisms that may underlie tumorigenesis...
  70. ncbi Levels of inbreeding depression over seven generations of selfing in the androdioecious clam shrimp, Eulimnadia texana
    S C Weeks
    Department of Biology, The University of Akron, OH, USA
    J Evol Biol 17:475-84. 2004
    ..Therefore, delta in this species is likely due to associative overdominance caused by deleterious recessive alleles linked to the sex determining locus...
  71. ncbi Gender identity outcome in female-raised 46,XY persons with penile agenesis, cloacal exstrophy of the bladder, or penile ablation
    Heino F L Meyer-Bahlburg
    New York State Psychiatric Institute, New York, NY 10032, USA
    Arch Sex Behav 34:423-38. 2005
    ....
  72. pmc Redundant control of the Caenorhabditis elegans sperm/oocyte switch by PUF-8 and FBF-1, two distinct PUF RNA-binding proteins
    Jennifer L Bachorik
    Program in Cellular and Molecular Biology, Department of Biochemistry, and Howard Hughes Medical Institute, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 102:10893-7. 2005
    ..We suggest that PUF-8 and FBF-1 may control fog-2 expression, and that the sperm/oocyte decision occurs in the distal germ line...
  73. ncbi Sex determination: ways to evolve a hermaphrodite
    Christian Braendle
    Institut Jacques Monod, CNRS Universités Paris 6 and 7, Tour 43, 2 place Jussieu, 75251 Paris Cedex 05, France
    Curr Biol 16:R468-71. 2006
    ..elegans and C. briggsae, however, produce self-fertile hermaphrodites instead of females. These transitions to hermaphroditism evolved convergently through distinct modifications of germline sex determination mechanisms.
  74. pmc Precopulatory stabbing, hypodermic injections and unilateral copulations in a hermaphroditic sea slug
    Nils Anthes
    Animal Evolutionary Ecology, Zoological Institute, University of Tubingen, Auf der Morgenstelle 28, 72076 Tubingen, Germany
    Biol Lett 3:121-4. 2007
    ..quadrispinosum represents conflicting rather than complementary mating interests between mates...
  75. ncbi A C. elegans sperm TRP protein required for sperm-egg interactions during fertilization
    X Z Shawn Xu
    Howard Hughes Medical Institute and Division of Biology, California Institute of Technology, Pasadena, CA 91125 USA
    Cell 114:285-97. 2003
    ..As C. elegans oocytes lack egg coats, our data suggest that some TRPC family channels might function to mediate calcium influx during sperm-egg plasma membrane interactions leading to fertilization...
  76. ncbi The proximate determinants of sex ratio in C. elegans populations
    Asher D Cutter
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    Genet Res 81:91-102. 2003
    ..Finally, we discuss the short-term and long-term factors that are likely to affect sex ratio and breeding system evolution in species like C. elegans...
  77. ncbi Androgen imprinting of the brain in animal models and humans with intersex disorders: review and recommendations
    Zoltan Hrabovszky
    Surgical Department, Royal Children s Hospital, Melbourne, Victoria, Australia
    J Urol 168:2142-8. 2002
    ..We reviewed the evidence in animal and human studies to determine the possible role of early postnatal androgen production in gender development...
  78. pmc Evolution of sperm size in nematodes: sperm competition favours larger sperm
    C W LaMunyon
    Department of Molecular and Cellular Biology, University of Arizona, Tucson 85721, USA
    Proc Biol Sci 266:263-7. 1999
    ..Larger sperm have thus evolved in species with a greater risk of sperm competition. Our results support recent studies contending that sperm size may increase in response to sperm competition...
  79. pmc True hermaphroditism in a 46,XY individual, caused by a postzygotic somatic point mutation in the male gonadal sex-determining locus (SRY): molecular genetics and histological findings in a sporadic case
    A Braun
    Institute of Anthropology and Human Genetics, Children s Hospital, University of Munich, Germany
    Am J Hum Genet 52:578-85. 1993
    ..The origin of the patient's intersexuality is a postzygotic mutation of the SRY occurring in part of the gonadal tissue. This event caused the loss of the testis-determining function in affected cells...
  80. pmc Why are there males in the hermaphroditic species Caenorhabditis elegans?
    J R Chasnov
    Department of Mathematics, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
    Genetics 160:983-94. 2002
    ..elegans can support male-specific genes against mutational degeneration. This results in the continuing presence of functional males in a 99.9% hermaphroditic species in which outcrossing is disadvantageous to hermaphrodites...
  81. pmc Hermaphroditic, demasculinized frogs after exposure to the herbicide atrazine at low ecologically relevant doses
    Tyrone B Hayes
    Laboratory for Integrative Studies in Amphibian Biology, Group in Endocrinology, Museum of Vertebrate Zoology, Department of Integrative Biology, University of California, Berkeley, CA 94720 3140, USA
    Proc Natl Acad Sci U S A 99:5476-80. 2002
    ..Atrazine (> or =0.1 ppb) induced hermaphroditism and demasculinized the larynges of exposed males (> or =1.0 ppb)...
  82. pmc Suppressors of a lin-12 hypomorph define genes that interact with both lin-12 and glp-1 in Caenorhabditis elegans
    M Sundaram
    Department of Molecular Biology, Princeton University, New Jersey 08544
    Genetics 135:765-83. 1993
    ..These sel genes may therefore function in both lin-12 and glp-1 mediated cell fate decisions...
  83. pmc Larger sperm outcompete smaller sperm in the nematode Caenorhabditis elegans
    C W LaMunyon
    Department of Molecular and Cellular Biology, University of Arizona, Tucson 85741, USA
    Proc Biol Sci 265:1997-2002. 1998
    ..Our results provide evidence of a mechanism to support recent theoretical and comparative studies that suggest sperm competition can favour not small, but large sperm...
  84. ncbi A reliable endocrine test with human menopausal gonadotropins for diagnosis of true hermaphroditism in early infancy
    J P Mendez
    Research Unit in Developmental Biology, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico, DF, Mexico
    J Clin Endocrinol Metab 83:3523-6. 1998
    In true hermaphroditism diverse phenotypes and karyotypes are found; there are no distinctive laboratory features that can distinguish it from other intersex disorders, thus the diagnosis is made by the histological findings...
  85. pmc RNA and sex determination in Caenorhabditis elegans. Post-transcriptional regulation of the sex-determining tra-2 and fem-3 mRNAs in the Caenorhabditis elegans hermaphrodite
    A Puoti
    Department of Biology, University of Fribourg, Rue du Musée 10, 1700 Fribourg, Switzerland
    EMBO Rep 2:899-904. 2001
    ....
  86. pmc Increased competitiveness of nematode sperm bearing the male X chromosome
    C W LaMunyon
    Department of Molecular and Cellular Biology, University of Arizona, Tucson 85721, USA
    Proc Natl Acad Sci U S A 94:185-9. 1997
    ..Thus, the multiple levels of sperm competitiveness found in C. briggsae maximize outcrossing after mating while delaying the cost of making male offspring...
  87. ncbi Evolution of the PP2C family in Caenorhabditis: rapid divergence of the sex-determining protein FEM-2
    Paul Stothard
    Department of Biological Sciences, University of Alberta, Edmonton, Canada
    J Mol Evol 54:267-82. 2002
    ..fem-2 (RNAi) in C. elegans and C. briggsae caused germ-line feminization, but had no noticeable effect in CB5161. Thus the function of fem-2 in CB5161 remains uncertain...
  88. pmc Sex-dependent resistance to the pathogenic fungus Cryptococcus neoformans
    Maaike C W van den Berg
    Department of Molecular Pathobiology, University of Birmingham, UK
    Genetics 173:677-83. 2006
    ..Our results hint at an overlap between the pathways controlling immunity and longevity and raise the possibility that differential regulation of these pathways may contribute to sex-dependent and species-dependent variation...
  89. ncbi Evidence of a high percentage of intersex in the Mediterranean swordfish (Xiphias gladius L.)
    G De Metrio
    Department of Animal Health and Welfare, University of Bari, s p per Casamassima km 3, I 70010 Valenzano BA, Italy
    Mar Pollut Bull 46:358-61. 2003
    ..The presence of vitellogenin was demonstrated immunohistochemically in the liver of both intersex and normal males. These findings could be due to the exposure to oestrogen-mimicking substances...
  90. ncbi Alterations in ribosome biogenesis cause specific defects in C. elegans hermaphrodite gonadogenesis
    Roumen Voutev
    Department of Biology, New York University, New York, NY 10003 6688, USA
    Dev Biol 298:45-58. 2006
    ..We conclude that the C. elegans distal sheath is particularly sensitive to alterations in ribosome biogenesis and that ribosome biogenesis defects in one tissue can non-autonomously influence proliferation in an adjacent tissue...
  91. ncbi The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9
    B Conradt
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Cell 93:519-29. 1998
    ..We propose that EGL-1 activates programmed cell death by binding to and directly inhibiting the activity of CED-9, perhaps by releasing the cell death activator CED-4 from a CED-9/CED-4-containing protein complex...
  92. ncbi lin-1 has both positive and negative functions in specifying multiple cell fates induced by Ras/MAP kinase signaling in C. elegans
    Teresa Tiensuu
    Umeå Center for Molecular Pathogenesis, Umea University, SE 901 87 Umea, Sweden
    Dev Biol 286:338-51. 2005
    ..We also show that lin-1 apparently has both positive and negative functions during the specification of the fates of other cells in the worm requiring Ras/MAP kinase signaling...
  93. ncbi C. elegans EVI1 proto-oncogene, EGL-43, is necessary for Notch-mediated cell fate specification and regulates cell invasion
    Byung Joon Hwang
    Howard Hughes Medical Institute and Division of Biology, 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Development 134:669-79. 2007
    ..Thus, egl-43 integrates temporally distinct upstream regulatory events and helps program cell fate specification and cell invasion...
  94. pmc Expression of ram-5 in the structural cell is required for sensory ray morphogenesis in Caenorhabditis elegans male tail
    R Y Yu
    Department of Biology, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
    EMBO J 19:3542-55. 2000
    ..ram-5-dependent cell-cell communication is implicated in organizing the structural cell and the hypodermis, potentially through adhesion at the structural cell-hypodermal cell border...
  95. ncbi Genome-wide analysis of sex-enriched gene expression during C. elegans larval development
    Kara Thoemke
    Department of Genetics, Cell Biology, and Development, and Developmental Biology Center, University of Minnesota, Minneapolis, MN 55455, USA
    Dev Biol 284:500-8. 2005
    ..These results suggest that TRA-1 controls sexual dimorphism through a small number of intermediary regulators rather than by acting directly on the full constellation of genes involved in sex-specific differentiation...
  96. ncbi SDC-3 coordinates the assembly of a dosage compensation complex on the nematode X chromosome
    T L Davis
    Department of Molecular and Cell Biology, University of California, Berkeley 94720 3204, USA
    Development 124:1019-31. 1997
    ..Our experiments suggest the possible involvement of zinc finger motifs in X chromosome recognition and the amino-terminal region in interactions with other dosage compensation proteins...
  97. ncbi The C. elegans gene lin-9,which acts in an Rb-related pathway, is required for gonadal sheath cell development and encodes a novel protein
    G J Beitel
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Gene 254:253-63. 2000
    ..We suggest that lin-9 is the founding member of a new protein family that functions in Rb-related pathways in many species...
  98. pmc Embryonic morphogenesis in Caenorhabditis elegans integrates the activity of LET-502 Rho-binding kinase, MEL-11 myosin phosphatase, DAF-2 insulin receptor and FEM-2 PP2c phosphatase
    A J Piekny
    Genes and Development Research Group and Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    Genetics 156:1671-89. 2000
    ..fem-2 blocked the near-normal elongation of let-502; mel-11 indicating that fem-2 acts in a parallel elongation pathway. The action of two redundant pathways likely ensures accurate elongation of the C. elegans embryo...
  99. ncbi gon-4, a cell lineage regulator required for gonadogenesis in Caenorhabditis elegans
    L Friedman
    Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Dev Biol 228:350-62. 2000
    ..We conclude that gon-4 is a regulator of the early lineage of Z1 and Z4 and suggest that it is a part of a genetic program common to the regulation of both hermaphrodite and male gonadogenesis...
  100. ncbi Reproduction and longevity: secrets revealed by C. elegans
    Arnab Mukhopadhyay
    Program in Gene Function and Expression, Program in Molecular Medicine, University of Massachusetts Medical School 364 Plantation Street, Worcester, MA 01605, USA
    Trends Cell Biol 17:65-71. 2007
    ..Here we discuss recent advances in our understanding of the regulation of life span by reproductive signaling, focusing on studies using Caenorhabditis elegans...
  101. ncbi Chromosome sites play dual roles to establish homologous synapsis during meiosis in C. elegans
    Amy J MacQueen
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 123:1037-50. 2005
    ..We speculate that concentration of these activities at one region per chromosome may have coevolved with the loss of a point centromere to safeguard karyotype stability...

Research Grants18

  1. Single Centriole-Mediated Gynogenesis in the Zebrafish
    Francisco J Pelegri; Fiscal Year: 2012
    ..This potentially provides to the zebrafish model a power similar to that of the hermaphroditism-based C. elegans genetics...
  2. The genetics of gamete sex control in convergent Caenorhabditis hermaphrodites
    JOSEPH ANDREW ROSS; Fiscal Year: 2011
    ..but different genetic alterations of the pathway independently produced the same sexual developmental trait, hermaphroditism, in both species...
  3. GONADAL AND PHENOTYPIC SEX DIFFERENTIATION
    FREDRICK GEORGE; Fiscal Year: 1993
    ..It is hoped that these studies will provide clues to disorders (such as true hermaphroditism, the XX male, pure gonadal dysgenesis, the vanishing testis, etc...
  4. STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF WT1
    J Joung; Fiscal Year: 2004
    ..efficiency of the +KTS splicing event have been associated with Frasier syndrome characterized by male pseudo-hermaphroditism, progressive glomerulonephropathy with chronic renal failure, and an increased risk of gonadoblastoma...
  5. ATRAZINE: IMPACT ON ENVIRONMENTAL AND PUBLIC HEALTH
    Tyrone Hayes; Fiscal Year: 2004
    ..induction of aromatase, has now been identified in amphibians, fish, and reptiles, and is consistent with the hermaphroditism observed in wildlife exposed to atrazine in the laboratory and field...
  6. Molecular Genetics of Hemicentin
    Bruce Vogel; Fiscal Year: 2006
    ....
  7. Gamete Interactions in Caenorhabditis elegans
    Andrew Singson; Fiscal Year: 2007
    ..This work will complement fertility studies in other organisms as well as provide insights into the mechanisms of cell-cell interactions and the diversity of reproductive strategies. [unreadable] [unreadable] [unreadable]..
  8. Regulation and Function of Hox gene lin-39 in C elegans
    DAVID EISENMANN; Fiscal Year: 2007
    ..elegans, for which full genomic sequence is available and functional genomic approaches are available. ..
  9. Gamete Interactions in Caenorhabditis elegans
    Andrew Singson; Fiscal Year: 2005
    ..This work will provide new insight into cell-cell interactions, conception and complement studies of fertilization in other organisms. ..
  10. GENDER IDENTITY--SEX REASSIGNMENT DUE TO GENITAL DEFECTS
    William Reiner; Fiscal Year: 2003
    ..The results of these studies should lead to more rational, research-informed, surgical and psychiatric approaches to these children and their families. ..
  11. AUTOSOMAL MECHANISMS OF TESTIS INDUCTION
    VICKI MEYERS WALLEN; Fiscal Year: 2005
    ..At the end of this grant period, we will have identified the gene causing this disorder and the step in the testis pathway that is altered by the mutation in timing, quantity, or location of gene expression. ..
  12. MAP kinase signal specificity in the C. elegans germline
    Valerie Reinke; Fiscal Year: 2007
    ..Together these experiments should build toward a comprehensive understanding of the mechanisms used to produce a specific cell fate in response to a generally used signaling pathway. ..
  13. The Genetics of Dauer Longevity
    PHILIP HARTMAN; Fiscal Year: 2003
    ..Collectively these experiments should provide a foundational basis for future, more systematic examinations of dauer longevity. ..
  14. The molecular basis for an animal model of inherited hyperuricosuria
    Danika Bannasch; Fiscal Year: 2007
    ..The elucidation of a novel gene function should provide new avenues of investigation for the treatment of the human condition. [unreadable] [unreadable] [unreadable]..
  15. GENETIC CONTROL OF MEIOTIC CHROMOSOME SEGREGATION
    Patricia Hunt; Fiscal Year: 2009
    ..The combined data from these studies will allow us to understand the control of recombination In mammals and how the events of prophase influence meiotic chromosome segregation. ..
  16. Genetic Regulation of Mating Behavior in C. elegan Males
    Luis Garcia; Fiscal Year: 2009
    ..Additionally, this project will identify components of activating pathways that must be attenuated by unc-103 during periods between mating. ..
  17. Conference on Mammalian Gametogenesis & Embryogenesis
    Patricia Hunt; Fiscal Year: 2002
    ..A particularly important aspect of the Gordon Conference setting is the blending of young and established investigators to promote exchanges that will generate new ideas and foster new collaborations in the field. ..
  18. The Mouse Oocyte: A New Assay for Reproductive Toxins
    Patricia Hunt; Fiscal Year: 2003
    ..In addition, because the observed meiotic disruption (congression failure) is an age-related defect in human oocytes, the data may provide important insight to human age-related aneuploidy. ..