type 2 diabetes mellitus

Summary

Summary: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.

Top Publications

  1. ncbi Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance
    J Tuomilehto
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    N Engl J Med 344:1343-50. 2001
  2. ncbi Physical activity and television watching in relation to risk for type 2 diabetes mellitus in men
    F B Hu
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Arch Intern Med 161:1542-8. 2001
  3. ncbi Television watching and other sedentary behaviors in relation to risk of obesity and type 2 diabetes mellitus in women
    Frank B Hu
    Department of Nutrition, Harvard School of Public Health, Boston, Mass 02115, USA
    JAMA 289:1785-91. 2003
  4. ncbi Global prevalence of diabetes: estimates for the year 2000 and projections for 2030
    Sarah Wild
    Public Health Sciences, University of Edinburgh, Edinburgh, Scotland
    Diabetes Care 27:1047-53. 2004
  5. ncbi Mechanisms linking obesity to insulin resistance and type 2 diabetes
    Steven E Kahn
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, 1660 South Columbian Way, Seattle, Washington 98108, USA
    Nature 444:840-6. 2006
  6. pmc Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
    William C Knowler
    Diabetes Prevention Program Coordinating Center, Biostatistics Center, George Washington University, 6110 Executive Blvd, Suite 750, Rockville, MD 20852, USA
    N Engl J Med 346:393-403. 2002
  7. ncbi The metabolic syndrome--a new worldwide definition
    K George M M Alberti
    Department of Endocrinology and Metabolism, St Marys Hospital, London W2 1NY, UK
    Lancet 366:1059-62. 2005
  8. ncbi PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
    Vamsi K Mootha
    Whitehead Institute MIT Center for Genome Research, Cambridge, Massachusetts, USA
    Nat Genet 34:267-73. 2003
  9. ncbi Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
    Alexandra E Butler
    Division of Endocrinology and Diabetes, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Diabetes 52:102-10. 2003
  10. ncbi Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement
    Scott M Grundy
    Circulation 112:2735-52. 2005

Detail Information

Publications259 found, 100 shown here

  1. ncbi Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance
    J Tuomilehto
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    N Engl J Med 344:1343-50. 2001
    b>Type 2 diabetes mellitus is increasingly common, primarily because of increases in the prevalence of a sedentary lifestyle and obesity...
  2. ncbi Physical activity and television watching in relation to risk for type 2 diabetes mellitus in men
    F B Hu
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Arch Intern Med 161:1542-8. 2001
    ..Television (TV) watching, a major sedentary behavior in the United States, has been associated with obesity. We hypothesized that prolonged TV watching may increase risk for type 2 diabetes...
  3. ncbi Television watching and other sedentary behaviors in relation to risk of obesity and type 2 diabetes mellitus in women
    Frank B Hu
    Department of Nutrition, Harvard School of Public Health, Boston, Mass 02115, USA
    JAMA 289:1785-91. 2003
    ..Current public health campaigns to reduce obesity and type 2 diabetes have largely focused on increasing exercise, but have paid little attention to the reduction of sedentary behaviors...
  4. ncbi Global prevalence of diabetes: estimates for the year 2000 and projections for 2030
    Sarah Wild
    Public Health Sciences, University of Edinburgh, Edinburgh, Scotland
    Diabetes Care 27:1047-53. 2004
    ..The goal of this study was to estimate the prevalence of diabetes and the number of people of all ages with diabetes for years 2000 and 2030...
  5. ncbi Mechanisms linking obesity to insulin resistance and type 2 diabetes
    Steven E Kahn
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, 1660 South Columbian Way, Seattle, Washington 98108, USA
    Nature 444:840-6. 2006
    ..This knowledge is fostering exploration of the molecular and genetic basis of the disease and new approaches to its treatment and prevention...
  6. pmc Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
    William C Knowler
    Diabetes Prevention Program Coordinating Center, Biostatistics Center, George Washington University, 6110 Executive Blvd, Suite 750, Rockville, MD 20852, USA
    N Engl J Med 346:393-403. 2002
    ..We hypothesized that modifying these factors with a lifestyle-intervention program or the administration of metformin would prevent or delay the development of diabetes...
  7. ncbi The metabolic syndrome--a new worldwide definition
    K George M M Alberti
    Department of Endocrinology and Metabolism, St Marys Hospital, London W2 1NY, UK
    Lancet 366:1059-62. 2005
  8. ncbi PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
    Vamsi K Mootha
    Whitehead Institute MIT Center for Genome Research, Cambridge, Massachusetts, USA
    Nat Genet 34:267-73. 2003
    ..Our results associate this gene set with clinically important variation in human metabolism and illustrate the value of pathway relationships in the analysis of genomic profiling experiments...
  9. ncbi Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
    Alexandra E Butler
    Division of Endocrinology and Diabetes, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Diabetes 52:102-10. 2003
    ....
  10. ncbi Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement
    Scott M Grundy
    Circulation 112:2735-52. 2005
  11. ncbi Cardiovascular morbidity and mortality associated with the metabolic syndrome
    B Isomaa
    Department of Internal Medicine, Jakobstad Hospital, Finland
    Diabetes Care 24:683-9. 2001
    ..To estimate the prevalence of and the cardiovascular risk associated with the metabolic syndrome using the new definition proposed by the World Health Organization..
  12. ncbi Insulin signalling and the regulation of glucose and lipid metabolism
    A R Saltiel
    Life Sciences Institute, Department of Medicine, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA
    Nature 414:799-806. 2001
    ..But recent studies have shown that numerous other hormones and signalling events attenuate insulin action, and are important in type 2 diabetes...
  13. pmc A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
    Timothy M Frayling
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter, UK
    Science 316:889-94. 2007
    ..67-fold increased odds of obesity when compared with those not inheriting a risk allele. This association was observed from age 7 years upward and reflects a specific increase in fat mass...
  14. ncbi The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
    Daniel J Drucker
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Lancet 368:1696-705. 2006
    ..However, long-term clinical studies are needed to determine the benefits of targeting the incretin axis for the treatment of type 2 diabetes...
  15. ncbi Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    J Clin Endocrinol Metab 86:1930-5. 2001
    ....
  16. pmc Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
    Takashi Kadowaki
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Clin Invest 116:1784-92. 2006
    ..This Review describes the pathophysiology of adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome...
  17. pmc Metformin and reduced risk of cancer in diabetic patients
    Josie M M Evans
    Division of Community Health Sciences, Section of Public Health, University of Dundee, Dundee DD2 4BF
    BMJ 330:1304-5. 2005
  18. ncbi Effect of a multifactorial intervention on mortality in type 2 diabetes
    Peter Gaede
    Steno Diabetes Center, Copenhagen, Denmark
    N Engl J Med 358:580-91. 2008
    ..agents - has been shown to reduce the risk of nonfatal cardiovascular disease among patients with type 2 diabetes mellitus and microalbuminuria...
  19. doi Effects of intensive glucose lowering in type 2 diabetes
    Hertzel C Gerstein
    N Engl J Med 358:2545-59. 2008
    ....
  20. pmc Long-term effects of a lifestyle intervention on weight and cardiovascular risk factors in individuals with type 2 diabetes mellitus: four-year results of the Look AHEAD trial
    Rena R Wing
    Department of Psychiatry, The Miriam Hospital Brown Medical School, Providence, RI 02860, USA
    Arch Intern Med 170:1566-75. 2010
    ..short-term improvements in glycemia and cardiovascular disease (CVD) risk factors in individuals with type 2 diabetes mellitus, but no long-term data are available...
  21. ncbi Global and societal implications of the diabetes epidemic
    P Zimmet
    International Diabetes Institute, 260 Kooyong Road, Caulfield, Victoria 3162, Australia
    Nature 414:782-7. 2001
    ..The prevention of diabetes and control of its micro- and macrovascular complications will require an integrated, international approach if we are to see significant reduction in the huge premature morbidity and mortality it causes...
  22. ncbi The hormone resistin links obesity to diabetes
    C M Steppan
    Department of Medicine, The Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Nature 409:307-12. 2001
    ..Insulin-stimulated glucose uptake by adipocytes is enhanced by neutralization of resistin and is reduced by resistin treatment. Resistin is thus a hormone that potentially links obesity to diabetes...
  23. ncbi Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis
    Leanne Bellamy
    Northwick Park Hospital, London, UK
    Lancet 373:1773-9. 2009
    ..We therefore did a comprehensive systematic review and meta-analysis to assess the strength of association between these conditions and the effect of factors that might modify the risk...
  24. doi Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes
    Anushka Patel
    N Engl J Med 358:2560-72. 2008
    ..In patients with type 2 diabetes, the effects of intensive glucose control on vascular outcomes remain uncertain...
  25. ncbi Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients
    K Hotta
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Arterioscler Thromb Vasc Biol 20:1595-9. 2000
    ..These results suggest that the decreased plasma adiponectin concentrations in diabetes may be an indicator of macroangiopathy...
  26. ncbi Diet, lifestyle, and the risk of type 2 diabetes mellitus in women
    F B Hu
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    N Engl J Med 345:790-7. 2001
    ..Previous studies have examined individual dietary and lifestyle factors in relation to type 2 diabetes, but the combined effects of these factors are largely unknown...
  27. ncbi The diabetes risk score: a practical tool to predict type 2 diabetes risk
    Jaana Lindström
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Diabetes Care 26:725-31. 2003
    ..Interventions to prevent type 2 diabetes should be directed toward individuals at increased risk for the disease. To identify such individuals without laboratory tests, we developed the Diabetes Risk Score...
  28. pmc Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study
    I M Stratton
    Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Radcliffe Infirmary, Oxford OX2 6HE
    BMJ 321:405-12. 2000
    ..To determine the relation between exposure to glycaemia over time and the risk of macrovascular or microvascular complications in patients with type 2 diabetes...
  29. ncbi Mitochondrial dysfunction and type 2 diabetes
    Bradford B Lowell
    Department of Medicine, Beth Israel Deaconess Medical Center, 99 Brookline Avenue, Harvard Medical School, Boston, MA 02215, USA
    Science 307:384-7. 2005
    ..Emerging evidence supports the potentially unifying hypothesis that both of these prominent features of type 2 diabetes are caused by mitochondrial dysfunction...
  30. ncbi Interleukin-1-receptor antagonist in type 2 diabetes mellitus
    Claus M Larsen
    Steno Diabetes Center, Gentofte, Denmark
    N Engl J Med 356:1517-26. 2007
    The expression of interleukin-1-receptor antagonist is reduced in pancreatic islets of patients with type 2 diabetes mellitus, and high glucose concentrations induce the production of interleukin-1beta in human pancreatic beta cells, ..
  31. pmc Islet beta cell failure in type 2 diabetes
    Marc Prentki
    Molecular Nutrition Unit and Montreal Diabetes Research Center, University of Montreal and Centre Hospitalier de l Université de Montréal, Montreal, Quebec, Canada
    J Clin Invest 116:1802-12. 2006
    ..The likely mechanisms of beta cell failure are discussed within the two broad categories: those with initiation and those with progression roles...
  32. ncbi Active smoking and the risk of type 2 diabetes: a systematic review and meta-analysis
    Carole Willi
    Department of Ambulatory Care and Community Medicine, University of Lausanne, Lausanne, Switzerland
    JAMA 298:2654-64. 2007
    ..Observational studies have suggested an association between active smoking and the incidence of type 2 diabetes...
  33. ncbi 10-year follow-up of intensive glucose control in type 2 diabetes
    Rury R Holman
    Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, Headington, Oxford OX3 7LJ, United Kingdom
    N Engl J Med 359:1577-89. 2008
    During the United Kingdom Prospective Diabetes Study (UKPDS), patients with type 2 diabetes mellitus who received intensive glucose therapy had a lower risk of microvascular complications than did those receiving conventional dietary ..
  34. ncbi Diabetes and atherosclerosis: epidemiology, pathophysiology, and management
    Joshua A Beckman
    Leducq Center for Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    JAMA 287:2570-81. 2002
    ..Complications of atherosclerosis cause most morbidity and mortality in patients with diabetes mellitus. Despite the frequency and severity of disease, proven medical therapy remains incompletely understood and underused...
  35. ncbi The influence of glucose-lowering therapies on cancer risk in type 2 diabetes
    C J Currie
    School of Medicine, Cardiff University, The Pharma Research Centre, Cardiff Medicentre, Cardiff, CF14 4UJ, UK
    Diabetologia 52:1766-77. 2009
    ..We examined the risk of development of solid tumours in relation to treatment with oral agents, human insulin and insulin analogues...
  36. ncbi The prevalence of comorbid depression in adults with diabetes: a meta-analysis
    R J Anderson
    Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA
    Diabetes Care 24:1069-78. 2001
    ..CONCLUSIONS--The presence of diabetes doubles the odds of comorbid depression. Prevalence estimates are affected by several clinical and methodological variables that do not affect the stability of the ORs...
  37. ncbi Epidemic obesity and type 2 diabetes in Asia
    Kun Ho Yoon
    Divison of Endocrinology and Metabolism, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea
    Lancet 368:1681-8. 2006
    ..At the level of primary prevention, such programmes can be linked to other non-communicable disease prevention programmes that target lifestyle-related issues. The cost of inaction is clear and unacceptable...
  38. ncbi Metabolic syndrome as a precursor of cardiovascular disease and type 2 diabetes mellitus
    Peter W F Wilson
    The NHLBI s Framingham Heart Study, Framingham, Massachusetts, USA
    Circulation 112:3066-72. 2005
    The incidence of cardiovascular disease (CVD), coronary heart disease (CHD), and type 2 diabetes mellitus (T2DM) has not been well defined in persons with the metabolic syndrome (at least 3 of the following: abdominal adiposity, low HDL ..
  39. ncbi Human endothelial progenitor cells from type II diabetics exhibit impaired proliferation, adhesion, and incorporation into vascular structures
    Oren M Tepper
    Laboratory of Microvascular Research and Vascular Tissue Engineering, Institute of Reconstructive Plastic Surgery, New York University Medical Center, New York, NY 10016, USA
    Circulation 106:2781-6. 2002
    ..Because diabetic complications occur in conditions in which EPC contributions have been demonstrated, EPC dysfunction may be important in their pathophysiology...
  40. ncbi Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group
    R C Turner
    Radcliffe Infirmary, Oxford, England
    JAMA 281:2005-12. 1999
    ..with diet alone, insulin, sulfonylurea, or metformin is known to improve glycemia in patients with type 2 diabetes mellitus, but which treatment most frequently attains target fasting plasma glucose (FPG) concentration of less ..
  41. ncbi Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes
    Louis Monnier
    Department of Metabolic Diseases, Lapeyronie Hospital, University of Montpellier, Montpellier, France
    JAMA 295:1681-7. 2006
    ..Glycemic disorders, one of the main risk factors for cardiovascular disease, are associated with activation of oxidative stress...
  42. ncbi The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up study
    Guangwei Li
    Department of Endocrinology, China Japan Friendship Hospital, Beijing, China
    Lancet 371:1783-9. 2008
    ..We aimed to assess whether intensive lifestyle interventions have a long-term effect on the risk of diabetes, diabetes-related macrovascular and microvascular complications, and mortality...
  43. ncbi Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity
    E Bonora
    Division of Endocrinology and Metabolic Diseases, University of Verona Medical School, Italy
    Diabetes Care 23:57-63. 2000
    ..To evaluate whether the homeostasis model assessment (HOMA) is a reliable surrogate measure of in vivo insulin sensitivity in humans...
  44. ncbi Aortic pulse-wave velocity and its relationship to mortality in diabetes and glucose intolerance: an integrated index of vascular function?
    Kennedy Cruickshank
    Clinical Epidemiology Group, School of Epidemiology and Health Sciences, University of Manchester Medical School, Manchester, UK
    Circulation 106:2085-90. 2002
    ..We tested whether aortic PWV predicts cardiovascular and all-cause mortality in type 2 diabetes and glucose-tolerance-tested (GTT) multiethnic population samples...
  45. pmc Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): a randomised controlled trial
    D Russell-Jones
    Department of Diabetes and Endocrinology, Royal Guildford Hospital, UK
    Diabetologia 52:2046-55. 2009
    The aim of the study was to compare the efficacy and safety of liraglutide in type 2 diabetes mellitus vs placebo and insulin glargine (A21Gly,B31Arg,B32Arg human insulin), all in combination with metformin and glimepiride.
  46. ncbi A central role for JNK in obesity and insulin resistance
    Jiro Hirosumi
    Division of Biological Sciences and Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA
    Nature 420:333-6. 2002
    Obesity is closely associated with insulin resistance and establishes the leading risk factor for type 2 diabetes mellitus, yet the molecular mechanisms of this association are poorly understood...
  47. ncbi Depression and diabetes: impact of depressive symptoms on adherence, function, and costs
    P S Ciechanowski
    Box 356560, Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA
    Arch Intern Med 160:3278-85. 2000
    ..We explored the impact of depressive symptoms in primary care patients with diabetes on diabetes self-care, adherence to medication regimens, functioning, and health care costs...
  48. ncbi Sugar-sweetened beverages, weight gain, and incidence of type 2 diabetes in young and middle-aged women
    Matthias B Schulze
    Department of Nutrition, Harvard School of Public Health, Boston, Mass, USA
    JAMA 292:927-34. 2004
    ....
  49. ncbi Atorvastatin in patients with type 2 diabetes mellitus undergoing hemodialysis
    Christoph Wanner
    Division of Nephrology, Department of Medicine, University of Wurzburg, Wurzburg, Germany
    N Engl J Med 353:238-48. 2005
    Statins reduce the incidence of cardiovascular events in persons with type 2 diabetes mellitus. However, the benefit of statins in such patients receiving hemodialysis, who are at high risk for cardiovascular disease and death, has not ..
  50. ncbi Glucose control and vascular complications in veterans with type 2 diabetes
    William Duckworth
    Phoenix Veterans Affairs Health Care Center, Phoenix, AZ 85012, USA
    N Engl J Med 360:129-39. 2009
    The effects of intensive glucose control on cardiovascular events in patients with long-standing type 2 diabetes mellitus remain uncertain.
  51. ncbi Effectiveness of self-management training in type 2 diabetes: a systematic review of randomized controlled trials
    S L Norris
    Division of Diabetes Translation, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Diabetes Care 24:561-87. 2001
    ..To systematically review the effectiveness of self-management training in type 2 diabetes...
  52. pmc An Environment-Wide Association Study (EWAS) on type 2 diabetes mellitus
    Chirag J Patel
    Department of Pediatrics and Medicine, Stanford University School of Medicine, Stanford, California, USA
    PLoS ONE 5:e10746. 2010
    ..We conducted a pilot Environmental-Wide Association Study (EWAS), in which epidemiological data are comprehensively and systematically interpreted in a manner analogous to a Genome Wide Association Study (GWAS)...
  53. ncbi Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress
    Katherine Esposito
    Department of Geriatric and Metabolic Diseases, Second University of Naples, Italy
    Circulation 106:2067-72. 2002
    ..We assessed the role of glucose in the regulation of circulating levels of IL-6, TNF-alpha, and interleukin-18 (IL-18) in subjects with normal or impaired glucose tolerance (IGT), as well as the effect of the antioxidant glutathione...
  54. ncbi The Indian Diabetes Prevention Programme shows that lifestyle modification and metformin prevent type 2 diabetes in Asian Indian subjects with impaired glucose tolerance (IDPP-1)
    A Ramachandran
    Diabetes Research Centre, M V Hospital for Diabetes, WHO Collaborating Centre for Research, Education and Training in Diabetes, Royapuram, Chennai, India
    Diabetologia 49:289-97. 2006
    ..In a prospective community-based study, we tested whether the progression to diabetes could be influenced by interventions in native Asian Indians with IGT who were younger, leaner and more insulin resistant than the above populations...
  55. ncbi The prevalence of co-morbid depression in adults with Type 2 diabetes: a systematic review and meta-analysis
    S Ali
    University of Leicester, Leicester, UK
    Diabet Med 23:1165-73. 2006
    ..To conduct a systematic literature review in order to estimate the prevalence and odds ratio of clinically relevant depression in adults with Type 2 diabetes compared with those without...
  56. ncbi Medical management of hyperglycaemia in type 2 diabetes mellitus: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes
    D M Nathan
    Diabetes Center, Massachusetts General Hospital, Boston, MA 02114, USA
    Diabetologia 52:17-30. 2009
    ..In this revision, we focus on the new classes of medications that now have more clinical data and experience...
  57. ncbi The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes
    S E Kahn
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle, Washington, USA
    Diabetologia 46:3-19. 2003
    ....
  58. ncbi Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?
    Joseph L Evans
    Medical Research Institute, San Francisco, California University of California at San Francisco, San Francisco, California 94107, USA
    Diabetes 52:1-8. 2003
    ....
  59. ncbi Comparison of abdominal adiposity and overall obesity in predicting risk of type 2 diabetes among men
    Youfa Wang
    Department of Human Nutrition and Division of Epidemiology and Biostatistics, University of Illinois at Chicago, USA
    Am J Clin Nutr 81:555-63. 2005
    ..However, few studies have compared the predictive power of overall obesity with that of central obesity. The cutoffs for waist circumference (WC) and waist-to-hip ratio (WHR) as measures of abdominal adiposity remain controversial...
  60. ncbi Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study
    Joachim Spranger
    Department of Endocrinology, Diabetes and Nutrition, Benjamin Franklin Medical Center, Free University Berlin, Berlin, Germany
    Diabetes 52:812-7. 2003
    ..These data strongly support the hypothesis that a subclinical inflammatory reaction has a role in the pathogenesis of type 2 diabetes...
  61. ncbi Comparison of body mass index, waist circumference, and waist/hip ratio in predicting incident diabetes: a meta-analysis
    Gabriela Vazquez
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 South Second Street, Minneapolis, MN 55454, USA
    Epidemiol Rev 29:115-28. 2007
    ..Although the clinical perspective focusing on central obesity is appealing, further research is needed to determine the usefulness of waist circumference or waist/hip ratio over body mass index...
  62. ncbi Self-management education for adults with type 2 diabetes: a meta-analysis of the effect on glycemic control
    Susan L Norris
    Division of Diabetes Translation, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Diabetes Care 25:1159-71. 2002
    ..To evaluate the efficacy of self-management education on GHb in adults with type 2 diabetes...
  63. ncbi The summary of diabetes self-care activities measure: results from 7 studies and a revised scale
    D J Toobert
    Chronic Illness Research Group, Oregon Research Institute, Eugene 97403 1983, USA
    Diabetes Care 23:943-50. 2000
    ..To review reliability, validity, and normative data from 7 different studies, involving a total of 1,988 people with diabetes, and provide a revised version of the Summary of Diabetes Self-Care Activities (SDSCA) measure...
  64. ncbi Thiazolidinediones
    Hannele Yki-Jarvinen
    Division of Diabetes, Department of Medicine, University of Helsinki, Finland
    N Engl J Med 351:1106-18. 2004
  65. pmc Obesity-induced inflammatory changes in adipose tissue
    Kathryn E Wellen
    Department of Genetics and Complex Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA
    J Clin Invest 112:1785-8. 2003
    ..These studies prompt consideration of new models to include a major role for macrophages in the molecular changes that occur in adipose tissue in obesity...
  66. pmc New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes
    Gillian Libby
    Division of Clinical and Population Sciences and Education, University of Dundee, Dundee, UK
    Diabetes Care 32:1620-5. 2009
    ..Activation of AMPK can suppress tumor formation and inhibit cell growth in addition to lowering blood glucose levels. We tested the hypothesis that metformin reduces the risk of cancer in people with type 2 diabetes...
  67. ncbi Inflammation: the link between insulin resistance, obesity and diabetes
    Paresh Dandona
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo and Kaleida Health, 3 Gates Circle, Buffalo, NY 14209, USA
    Trends Immunol 25:4-7. 2004
    ..This might interfere with the anti-inflammatory effect of insulin, which in turn might promote inflammation...
  68. ncbi Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes
    Joseph L Evans
    University of California at San Francisco, San Francisco, California 94143, USA
    Endocr Rev 23:599-622. 2002
    ..Studies with antioxidants such as vitamin E, alpha-lipoic acid, and N-acetylcysteine suggest that new strategies may become available to treat these conditions...
  69. pmc Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice
    Charlotte Bonnard
    INSERM, U870, IFR62, Oullins, France
    J Clin Invest 118:789-800. 2008
    ..These data suggest that mitochondrial alterations do not precede the onset of insulin resistance and result from increased ROS production in muscle in diet-induced diabetic mice...
  70. pmc Trajectories of glycaemia, insulin sensitivity, and insulin secretion before diagnosis of type 2 diabetes: an analysis from the Whitehall II study
    Adam G Tabák
    Department of Epidemiology and Public Health, University College London, London, UK
    Lancet 373:2215-21. 2009
    ..We aimed to characterise trajectories of fasting and postload glucose, insulin sensitivity, and insulin secretion in individuals who develop type 2 diabetes...
  71. pmc Pharmacological and lifestyle interventions to prevent or delay type 2 diabetes in people with impaired glucose tolerance: systematic review and meta-analysis
    Clare L Gillies
    Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, University of Leicester, Leicester LE1 7RH
    BMJ 334:299. 2007
    ..To quantify the effectiveness of pharmacological and lifestyle interventions to prevent or delay type 2 diabetes in people with impaired glucose tolerance...
  72. ncbi Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin
    Samantha L Bowker
    Institute of Health Economics, Edmonton, Alberta, Canada
    Diabetes Care 29:254-8. 2006
    ..We explored the association between antidiabetic therapies and cancer-related mortality in patients with type 2 diabetes, postulating that agents that increase insulin levels might promote cancer...
  73. pmc Risk of malignancies in patients with diabetes treated with human insulin or insulin analogues: a cohort study
    L G Hemkens
    Institute for Quality and Efficiency in Health Care IQWiG, Dillenburger Strasse 27, D 51105, Cologne, Germany
    Diabetologia 52:1732-44. 2009
    ..The aim of this cohort study was to investigate the risk of malignant neoplasms and mortality in patients with diabetes treated either with human insulin or with one of three insulin analogues...
  74. pmc Excess risk of fatal coronary heart disease associated with diabetes in men and women: meta-analysis of 37 prospective cohort studies
    Rachel Huxley
    George Institute for International Health, University of Sydney, PO Box M201, Sydney, NSW 2050, Australia
    BMJ 332:73-8. 2006
    ..To estimate the relative risk for fatal coronary heart disease associated with diabetes in men and women...
  75. ncbi Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
    Steven E Nissen
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
    N Engl J Med 356:2457-71. 2007
    Rosiglitazone is widely used to treat patients with type 2 diabetes mellitus, but its effect on cardiovascular morbidity and mortality has not been determined.
  76. ncbi Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene
    M Elchebly
    Department of Biochemistry, McGill University, 3655 Drummond Street, Montreal, Quebec, Canada, H3G 1Y6
    Science 283:1544-8. 1999
    ..These results demonstrate that PTP-1B has a major role in modulating both insulin sensitivity and fuel metabolism, thereby establishing it as a potential therapeutic target in the treatment of type 2 diabetes and obesity...
  77. ncbi Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes
    R Paul Robertson
    Pacific Northwest Research Institute and the Departments of Medicine and Pharmacology, University of Washington, Seattle, Washington 98122, USA
    Diabetes 53:S119-24. 2004
    ....
  78. ncbi Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats
    G Xu
    Elliott P Joslin Research Laboratories, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    Diabetes 48:2270-6. 1999
    ..Thus, GLP-I and analogs thereof hold promise as a novel therapy to stimulate beta-cell growth and differentiation when administered to diabetic individuals with reduced beta-cell mass...
  79. ncbi Inflammation and metabolic disorders
    Gokhan S Hotamisligil
    Department of Genetics and Complex Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA
    Nature 444:860-7. 2006
    ..Collectively, these diseases constitute the greatest current threat to global human health and welfare...
  80. pmc Type-II diabetes and pancreatic cancer: a meta-analysis of 36 studies
    R Huxley
    The George Institute for International Health, The University of Sydney, PO Box M201, Missenden Road, Sydney NSW 2050, Australia
    Br J Cancer 92:2076-83. 2005
    ..1 vs 1.5; P=0.005). These results support a modest causal association between type-II diabetes and pancreatic cancer...
  81. ncbi Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes
    S J Creely
    Diabetes and Metabolism Research Laboratories, Clinical Sciences Research Institute, Warwick Medical School, Clinical Sciences Bldg, University Hospital Coventry and Warwickshire, Clifford Bridge Road, Coventry CV2 2DX, West Midlands, UK
    Am J Physiol Endocrinol Metab 292:E740-7. 2007
    ..Thus, increased adiposity may increase proinflammatory cytokines and therefore contribute to the pathogenic risk of T2DM...
  82. ncbi Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia
    Johan Rung
    McGill University and Genome Quebec Innovation Centre, Montreal, Canada
    Nat Genet 41:1110-5. 2009
    ....
  83. ncbi Low-grade systemic inflammation and the development of type 2 diabetes: the atherosclerosis risk in communities study
    Bruce B Duncan
    Graduate Studies Program in Epidemiology, School of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
    Diabetes 52:1799-805. 2003
    ..7 (P for linear trend = 0.008). In conclusion, a low-grade inflammation predicts incident type 2 diabetes. The association is absent in smokers and African-Americans...
  84. ncbi The brief illness perception questionnaire
    Elizabeth Broadbent
    Department of Psychological Medicine, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    J Psychosom Res 60:631-7. 2006
    ..This study evaluates the Brief Illness Perception Questionnaire (Brief IPQ), a nine-item scale designed to rapidly assess the cognitive and emotional representations of illness...
  85. pmc Fruit and vegetable intake and incidence of type 2 diabetes mellitus: systematic review and meta-analysis
    Patrice Carter
    Diabetes Research, Department of Cardiovascular Sciences, University of Leicester, Leicester LE1 5WW
    BMJ 341:c4229. 2010
    ..To investigate the independent effects of intake of fruit and vegetables on incidence of type 2 diabetes...
  86. ncbi Fatty liver: a novel component of the metabolic syndrome
    Anna Kotronen
    Department of Medicine, Division of Diabetes, University of Helsinki, Finland, FIN 00029 HUCH, Helsinki, Finland
    Arterioscler Thromb Vasc Biol 28:27-38. 2008
    ..Intervention studies have shown that liver fat can be decreased by weight loss, PPARgamma agonists, and insulin therapy...
  87. ncbi Insulin resistance and chronic cardiovascular inflammatory syndrome
    Jose Manuel Fernandez-Real
    Section of Diabetes, Endocrinology and Nutrition, University Hospital of Girona Dr Josep Trueta, 17007 Girona, Spain
    Endocr Rev 24:278-301. 2003
    ..Dysregulation of the inflammatory axis predicts the development of insulin resistance and type 2 diabetes mellitus. The knowledge of how interactions between metabolic and inflammatory pathways occur will be useful in ..
  88. ncbi Coffee, decaffeinated coffee, and tea consumption in relation to incident type 2 diabetes mellitus: a systematic review with meta-analysis
    Rachel Huxley
    The George Institute for International Health, The University of Sydney, Australia
    Arch Intern Med 169:2053-63. 2009
    Coffee consumption has been reported to be inversely associated with risk of type 2 diabetes mellitus. Similar associations have also been reported for decaffeinated coffee and tea...
  89. pmc Genotype score in addition to common risk factors for prediction of type 2 diabetes
    James B Meigs
    General Medicine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    N Engl J Med 359:2208-19. 2008
    Multiple genetic loci have been convincingly associated with the risk of type 2 diabetes mellitus. We tested the hypothesis that knowledge of these loci allows better prediction of risk than knowledge of common phenotypic risk factors ..
  90. ncbi The Diabetes Surgery Summit consensus conference: recommendations for the evaluation and use of gastrointestinal surgery to treat type 2 diabetes mellitus
    Francesco Rubino
    Department of Surgery, Section of Metabolic Surgery, Weill Cornell Medical College New York Presbyterian Hospital, New York, NY, USA
    Ann Surg 251:399-405. 2010
    ..To develop guidelines for the use of gastrointestinal surgery to treat type 2 diabetes and to craft an agenda for further research...
  91. ncbi Prediction of incident diabetes mellitus in middle-aged adults: the Framingham Offspring Study
    Peter W F Wilson
    Emory Program in Cardiovascular Outcomes Research and Epidemiology, Emory University School of Medicine, Atlanta, GA 30306, USA
    Arch Intern Med 167:1068-74. 2007
    Prediction rules for type 2 diabetes mellitus (T2DM) have been developed, but we lack consensus for the most effective approach.
  92. ncbi Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trial
    Philip D Home
    Newcastle Diabetes Centre and Newcastle University, Newcastle upon Tyne, UK
    Lancet 373:2125-35. 2009
    ..We assessed cardiovascular outcomes after addition of rosiglitazone to either metformin or sulfonylurea compared with the combination of the two over 5-7 years of follow-up. We also assessed comparative safety...
  93. ncbi Hypertensive pregnancy disorders and subsequent cardiovascular morbidity and type 2 diabetes mellitus in the mother
    Jacob A Lykke
    Department of Obstetrics, Rigshospitalet, Copenhagen, Denmark
    Hypertension 53:944-51. 2009
    ..between hypertensive pregnancy disorders and various subsequent cardiovascular events and the effect of type 2 diabetes mellitus on these...
  94. pmc Inflammation and insulin resistance
    Steven E Shoelson
    Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 116:1793-801. 2006
    ....
  95. pmc Cardiac outcomes after screening for asymptomatic coronary artery disease in patients with type 2 diabetes: the DIAD study: a randomized controlled trial
    Lawrence H Young
    Yale University School of Medicine, Section of Cardiovascular Medicine, Department of Internal Medicine, New Haven, CT 06520, USA
    JAMA 301:1547-55. 2009
    ..Coronary artery disease (CAD) is the major cause of mortality and morbidity in patients with type 2 diabetes. But the utility of screening patients with type 2 diabetes for asymptomatic CAD is controversial...
  96. pmc The estimated GFR, but not the stage of diabetic nephropathy graded by the urinary albumin excretion, is associated with the carotid intima-media thickness in patients with type 2 diabetes mellitus: a cross-sectional study
    Hiroyuki Ito
    Department of Diabetes, Metabolism and Kidney Disease, Edogawa Hospital, Tokyo, Japan
    Cardiovasc Diabetol 9:18. 2010
    ..carotid artery and the stage of chronic kidney disease (CKD) based on the estimated glomerular filtration rate (eGFR) and diabetic nephropathy graded by the urinary albumin excretion (UAE) in the patients with type 2 diabetes mellitus.
  97. pmc Role of AMP-activated protein kinase in mechanism of metformin action
    G Zhou
    Department of Molecular Endocrinology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    J Clin Invest 108:1167-74. 2001
    ..Activation of AMPK provides a unified explanation for the pleiotropic beneficial effects of this drug; these results also suggest that alternative means of modulating AMPK should be useful for the treatment of metabolic disorders...
  98. pmc Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1
    Mary Elizabeth Patti
    Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 100:8466-71. 2003
    b>Type 2 diabetes mellitus (DM) is characterized by insulin resistance and pancreatic beta cell dysfunction. In high-risk subjects, the earliest detectable abnormality is insulin resistance in skeletal muscle...
  99. ncbi Metformin: an update
    Dmitri Kirpichnikov
    State University of New York Health Science Center at Brooklyn, 450 Clarkson Avenue, Box 1205, Brooklyn, New York 11203, USA
    Ann Intern Med 137:25-33. 2002
    ..Its efficacy in reducing hyperglycemia in type 2 diabetes mellitus is similar to that of sulfonylureas, thiazolidinediones, and insulin...
  100. ncbi Selective beta-cell loss and alpha-cell expansion in patients with type 2 diabetes mellitus in Korea
    Kun Ho Yoon
    Department of Endocrinology and Metabolism, Immunology, and Cell Biology Core Laboratory, Institutes of Medical Science, The Catholic University of Korea, Seoul, Korea 137 701
    J Clin Endocrinol Metab 88:2300-8. 2003
    ..Moreover, decreased beta-cell but increased alpha-cell proportion in the islets suggests for a selective beta-cell loss in the pathogenesis of Korean type 2 diabetes...
  101. pmc Metabolic syndrome and its components as predictors of incident type 2 diabetes mellitus in an Aboriginal community
    Sylvia H Ley
    Department of Nutritional Sciences, University of Toronto, Toronto, Ont
    CMAJ 180:617-24. 2009
    ..We aimed to determine the incidence of type 2 diabetes in an Aboriginal community and to evaluate prospective associations with metabolic syndrome and its components...

Research Grants71

  1. Pyruvate Dehydrogenase kinase as Therapeutic Target for Hepatic Steatosis, Obesit
    Robert A Harris; Fiscal Year: 2012
    ..27,000 Americans die each year from cirrhosis. Hepatic steatosis, obesity, insulin resistance, and type 2 diabetes mellitus are all closely linked [64]...
  2. Correction of glutathione deficiency for treatment of diabetic nephropathy
    Paolo Fanti; Fiscal Year: 2013
    ..high production and low disposal of toxic pro-oxidant chemicals, and it is very common in patients with Type 2 Diabetes Mellitus (T2DM) and diabetic kidney disease...
  3. Effects of Evoked Resistance Training and Testosterone after Spinal Cord Injury
    Ashraf Gorgey; Fiscal Year: 2012
    ..for the deterioration in body composition and metabolic profiles and leads to increase obesity, type 2 diabetes mellitus, dyslipidemia and subsequently cardiovascular disease...
  4. Ang II and Overnutrition and Insulin resistance in Cardiovascular Tissue
    JAMES RUSSELL SOWERS; Fiscal Year: 2013
    ..normal metabolic actions of insulin is often present in persons with hypertension and is a precursor for type 2 diabetes mellitus and cardiovascular disease...
  5. MOLECULAR BASIS OF INSULIN RESISTANCE
    Maureen J Charron; Fiscal Year: 2010
    The incidence of Type 2 diabetes mellitus (T2DM) and the Metabolic Syndrome has reached epidemic proportions. Human and rodent studies provide strong support for a genetic predisposition to these pathologies...
  6. REGULATION OF GENE EXPRESSION BY DIETARY FAT
    Lisa M Salati; Fiscal Year: 2012
    ..This project will provide important new data on the ways in which dietary fat can regulate intracellular metabolism. ..
  7. INSULIN RECEPTORS AND THE GLUCOSE TRANSPORT SYSTEM
    JERROLD MICHAEL OLEFSKY; Fiscal Year: 2013
    ..These studies should lead to an improved understanding of the basic causes of Type 2 diabetes mellitus and hold the potential for new therapeutic modalities.
  8. Regulation of microRNA-375 by cyclic-AMP in pancreatic beta-cells
    DAVID MATTHEW KELLER; Fiscal Year: 2010
    ..For this reason, the cAMP signaling pathway is currently being targeted by therapeutics for type 2 diabetes mellitus (Drucker and Nauck, 2006)...
  9. Surgical amelioration of type 2 diabetes: Hormones, microbiota and mitochondria
    PETER J contact HAVEL; Fiscal Year: 2010
    ..The contributions of alterations in the production of gastrointestinal and adipocyte hormones, changes of bile acids and intestinal microbial composition, as well as mitochondrial function will be assessed. ..
  10. A2b Adenosine Receptor Regulation of Metabolic Disease and Inflammation
    Anna Eisenstein; Fiscal Year: 2013
    ..Ravid, a Biochemist and expert in vascular and adenosine biology, and Dr. Gokce, a Clinician Scientist with access to human samples and expertise in studying human adipose tissue. ..
  11. N-Acetylcysteine and Milk Thistle for Treatment of Diabetic Nephropathy
    Paolo Fanti; Fiscal Year: 2011
    ..of oxidative stress and inflammation, which are characteristically observed in patients with type 2 diabetes mellitus (T2DM) and related nephropathy...
  12. Obesity: neural control of body weight and metabolism
    Barry E Levin; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Obesity and its related morbities of type 2 diabetes mellitus and hypertension have reached epidemic proportions in adults and children in the United States...
  13. PET Imaging of Myocardial Oxidative Stress in T2DM
    KOORESH ISAAC SHOGHI; Fiscal Year: 2013
    ..abstract_text> ..
  14. Atypical PKC Knockout Models: Effect on Glucose and Lipid Homeostasis
    Robert V Farese; Fiscal Year: 2013
    ..e., a "metabolic syndrome" (MS), and ultimately type 2 diabetes mellitus (T2DM)...
  15. A Culturally Tailored LIfestyle Intervention to Prevent Diabetes in South Asians:
    KABAYAM M VENKAT NARAYAN; Fiscal Year: 2010
    ..South Asians, a rapidly growing segment of the US population, have significantly higher rates of Type 2 Diabetes Mellitus (T2DM), get T2DM at younger ages, and do worse health-wise once they have T2DM than the general ..
  16. Protein alterations in skeletal muscle cells with improved mtDNA repair
    Lyudmila I Rachek; Fiscal Year: 2010
    ..muscular free fatty acids (FFA) accumulation might be responsible for mitochondrial dysfunction in type 2 diabetes mellitus (T2DM)...
  17. Effects of periodontitis on insulin target organs and glucose homeostasis
    Keiko Watanabe; Fiscal Year: 2013
    ..Epidemiological and clinical studies have established an association between periodontitis and Type 2 Diabetes Mellitus (T2DM)/obesity. However, the causality and mechanisms linking periodontitis to T2DM are not known...
  18. Beta Cell Adaptation to Stress in Baboon Pancreas After Partial Pancreatectomy
    FRANCO BATTISTA FOLLI; Fiscal Year: 2010
    ..unreadable]-amyloid (A[unreadable]) fibrils and oligomers, suggesting a similar pathogenesis of type 2 diabetes mellitus (T2DM) and AD...
  19. Improving Hmong Health through Community Based Participatory Research
    DIAN LORENE BAKER; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The U.S. Hmong population experiences Type 2 diabetes mellitus (T2DM) at disproportionate rates when compared to Non-Hispanic whites (24 percent vs. 10.2 percent)...
  20. The Role of Circadian Periodicity in Human Cardiovascular Disease and Diabetes
    John P Forman; Fiscal Year: 2013
    ..in cross- sectional studies;furthermore, polymorphisms in the melatonin receptors are associated with type 2 diabetes mellitus (T2DM)...
  21. Characterization of an essential mitochondrial rRNA methyltransferase
    Kip E Guja; Fiscal Year: 2013
    ..The goal of this proposal is to provide a more complete understanding of how TFB proteins influence disease pathogenesis by elucidating the roles that they play in mitochondrial gene expression. ..
  22. Metabolic Crosstalk Between Immune Cells and the Liver in Obesity
    BENJAMIN MANTELL; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Obesity and type 2 diabetes mellitus (T2DM) are two devastating diseases that are growing in prevalence to epidemic proportions...
  23. Genome-wide DNA Methylation Profiles Associated with Abnormal Intrauterine Growth
    Cristina Montagna; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Type 2 diabetes mellitus (T2DM) is an example of a major age-related disease that has risen dramatically in adults in the last two decades(1)...
  24. Nonenzymatic glycation, bone quality, and microdamage in type 2 diabetic bone
    Eve Donnelly; Fiscal Year: 2013
    ..Research: Individuals with type 2 diabetes mellitus (T2DM) paradoxically have increased fracture risk despite normal or greater bone mineral density relative ..
  25. PERIPHERAL AND CENTRAL INTERACTIONS IN ENERGY BALANCE
    Barbara B Kahn; Fiscal Year: 2010
    ..Obesity and related disorders such as Type 2 diabetes mellitus are major healthcare issues in the United States, and decreasing their incidence in adults and children ..
  26. Fatty Acid Defects &Oxidative Stress Modulate Islet Function in Cystic Fibrosis
    Aliye Uc; Fiscal Year: 2013
    ..and fatty acid perturbations have well-established roles in the pathophysiology of lung disease in CF and type 2 diabetes mellitus, but have not been studied in CFRD...
  27. Progesterone's Role in Pubertal Maturation in Normal and Hyperandrogenemic Adoles
    JESSICAH S P COLLINS; Fiscal Year: 2011
    ..menstrual cycles and infertility and causes an increased risk for obesity, the metabolic syndrome, and type 2 diabetes mellitus. Although PCOS is common and associated with significant morbidity, the etiology remains unknown...
  28. Endogenous Aldosterone and Glucose Homeostasis
    JAMES MATTHEW LUTHER; Fiscal Year: 2013
    ..They also reduce the incidence of type 2 Diabetes Mellitus (T2DM) in retrospective analyses of clinical trials...
  29. Tunable Insulin Resistance in a Drosophila Model of Diabetes
    ELENA M GRACHEVA; Fiscal Year: 2010
    ....
  30. A PROOF-OF-CONCEPT CLINICAL TRIAL OF XENIN-25 IN THE TREATMENT OF TYPE 2 DIABETES
    Burton M Wice; Fiscal Year: 2010
    ..b>Type 2 diabetes mellitus (T2DM) is the commonest form of diabetes accounting for well over 80% of cases...
  31. Epigenomic Regulation of Gene Expression in Diet Induced Obesity
    Donald K Scott; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Obesity and its related disorders, including type 2 diabetes mellitus, metabolic syndrome, and cardiovascular disease, have reached epidemic levels in the United States...
  32. INSULIN ACTION IN MUSCLE AND FAT CELLS
    JAMES CARLTON GARRISON; Fiscal Year: 2010
    ..A defect in the ability of these cells to respond to insulin is a primary cause of Type 2 diabetes mellitus, which in turn is a leading cause of vision disorders, neuropathy, kidney disease, peripheral vascular ..
  33. NAFLD in T2DM: Prevalence in Hispanics and Role of Treatment
    Kenneth Cusi; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: It is well known that nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) are major public health problems...
  34. Skeletal Muscle Mitochondrial Adaptations to a Two-Year Caloric Restiction
    STEVEN RICHARD SMITH; Fiscal Year: 2012
    ..DYSFUNCTION is an important component of many of the pathologies associated with aging, such as type 2 diabetes mellitus, Alzheimer's disease, Parkinson's disease, and some cancers...
  35. NKT cells, fatty acids, and insulin resistance
    CURTIS LEE GABRIEL; Fiscal Year: 2010
    ..for Disease Control, nearly 33% of adults can be classified as obese or overweight and the incidence of type 2 diabetes mellitus (T2DM) is rapidly rising...
  36. North Lawndale Diabetes Community Action Project
    STEVEN contact WHITMAN; Fiscal Year: 2010
    ..5 among persons with type 2 diabetes mellitus living in a medically underserved urban neighborhood...
  37. PET Imaging Agent for Diabetes Mellitus
    JOGESH MUKHERJEE; Fiscal Year: 2010
    ..application addresses broad Challenge Area (03) Biomarker Discovery and Validation and specific Challenge Topic 03-DK-101: "Discovery of biomarkers for disease risk, progression or response to therapy in diseases of interest to NINDK" ..
  38. Autophagy and human islet amyloid polypeptide in animal models of type 2 diabetes
    Jacqueline Rivera; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Type 2 diabetes mellitus (T2DM) is a major cause of premature morbidity and mortality in the US and many emerging nations...
  39. Mechanisms of Coronary Arteriolar Dysfunction in Type 2 Diabetes
    Khalid Matrougui; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Type 2 diabetes mellitus and cardiovascular disease contribute to a high proportion of the burden of disease in the UNITED STATES...
  40. Predictors of tuberculosis by stage of insulin resistance
    Alicia Hsin Ming Chang; Fiscal Year: 2013
    ..S. and in the world. ..
  41. VITAMIN D DEFICIENCY, INSULIN RESISTANCE AND CARDIOVASCULAR DISEASE
    Carlos Bernal-Mizrachi; Fiscal Year: 2013
    ..by applicant): Cardiovascular disease is the leading cause of morbidity and mortality in patients with Type 2 diabetes mellitus (Type 2 DM)...
  42. The Magnesium and Metabolic Syndrome Trial
    Stella Lucia Volpe; Fiscal Year: 2010
    ..with the metabolic syndrome could improve insulin sensitivity and prevent or delay the onset of type 2 diabetes mellitus and its complications...
  43. Insulin action in human cardiac and skeletal muscle microvasculature
    Zhenqi Liu; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Patients with type 2 diabetes mellitus (T2DM) frequently develop cardiovascular complications which contribute significantly to morbidity and mortality...
  44. A Clinical Trial to Prevent New Onset Diabetes After Transplantation
    Akinlolu O Ojo; Fiscal Year: 2013
    ..NODAT is a form type 2 diabetes mellitus that afflicts up to 30% of kidney transplant recipients who survive through the third post transplant ..
  45. Lactation and Incidence of Diabetes Mellitus in CARDIA Women
    ERICA PAULINE GUNDERSON; Fiscal Year: 2013
    ..effects on cardiometabolic risk factor levels that persist after weaning, and may prevent the onset of type 2 diabetes mellitus (DM) in women in mid to late life...
  46. MAP KINASE IN ISLET FUNCTION
    Melanie H Cobb; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Type 2 diabetes mellitus is now found not only in adults but also in children in the United States...
  47. TPL2: A Central Node in Obesity-Associated Inflammation and Metabolic Disorders
    Andrew S Greenberg; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Obesity is a major independent risk factor for type 2 diabetes mellitus (T2DM), obesity promotes chronic macrophage-mediated adipose tissue inflammation, resulting in increased release of free fatty ..
  48. MAP Kinase Phosphatase 3 (MKP-3) and Obesity-related Gluconeogenesis
    Haiyan Xu; Fiscal Year: 2013
    Obesity-related type 2 diabetes mellitus, characterized by insulin resistance, currently affects 150 million people worldwide...
  49. Activation of Atypical PKC by Insulin and Other Agonists
    ROBERT VITO FARESE; Fiscal Year: 2013
    ..Also, in multiple rodent models of obesity (O) and type 2 diabetes mellitus (T2DM), we defined the following tissue-specific defects in insulin signaling factors: (a) aPKC ..
  50. The regulation and activation of STATs in adipocytes
    Jacqueline M Stephens; Fiscal Year: 2013
    ..Our studies focus on understanding the function of STAT 5 proteins in fat cells and how these transcription factors affect lipogenesis, insulin sensitivity, and the production of endocrine factors in adipocytes. ..
  51. THE ROLE OF THE AKT/PKB SIGNALING IN INSULIN ACTION
    MORRIS JAY BIRNBAUM; Fiscal Year: 2013
    ..It is the aim of these studies to understand why lipid metabolism is so disturbed in Type II Diabetes Mellitus and to identify novel targets to treat this aspect of the disease. ..
  52. A novel axis regulates adipocyte plasticity
    Sean Hartig; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Obesity, insulin resistance, and type 2 diabetes mellitus (T2DM) affects one in 10 U.S. adults with direct annual medical costs near $120 billion...
  53. Environmental arsenic and diabetes mellitus
    Miroslav Styblo; Fiscal Year: 2012
    ..linked chronic exposures to high or moderate levels of iAs in drinking water to an increased risk for type 2 diabetes mellitus (T2D)...
  54. Cardiovascular effects of GLP-1 in obesity/metabolic syndrome
    Johnathan D Tune; Fiscal Year: 2013
    ..impaired myocardial GLP-1 responses in the setting of the obese-metabolic syndrome (MetS) in swine and type 2 diabetes mellitus in humans...
  55. ACCORD
    Faramarz Ismail Beigi; Fiscal Year: 2010
    ACCORD Trial Purpose and Design (June 30, 2006). Patients with type 2 diabetes mellitus die of cardiovascular disease (CVD) at rates two to four times higher than non-diabetic populations of similar demographic characteristics...
  56. ACCORD
    Richard Grimm; Fiscal Year: 2010
    ACCORD Trial Purpose and Design (June 30, 2006). Patients with type 2 diabetes mellitus die of cardiovascular disease (CVD) at rates two to four times higher than non-diabetic populations of similar demographic characteristics...
  57. Isoform specific effects of the autoinhibitory element and the C-terminus of nitr
    JOHN SALERNO; Fiscal Year: 2009
    ..More sophisticated kinetic analysis will allow us to obtain deeper insights than previous experiments with control element chimera. ..
  58. Identification of Muscle-Specific Biomarkers of Fatty Acid beta-Oxidation
    SEAN HARRISON ADAMS; Fiscal Year: 2012
    ..hormone insulin to trigger tissue uptake of blood sugar is an early event in the course of development of type 2 diabetes mellitus (T2DM), and the muscle beds are important sites for this phenomenon in many people...
  59. Virtual Screening Development to Complement Experimental Screening for PPAR Modul
    Stephanie N Lewis; Fiscal Year: 2012
    ....
  60. DIABETES WELLNESS--AMERICAN INDIAN TALKING CIRCLES
    Felicia Hodge; Fiscal Year: 2001
    ..During this final year, control sites will be provided all educational materials and one training session per site. ..
  61. Targeting Inflammation to Improve Endothelial Function in Type 2 Diabetes: A Subs
    Mark A Creager; Fiscal Year: 2010
    ..Insulin resistance states, including type 2 diabetes mellitus, are associated with decreased bioavailability of endothelium-derived nitric oxide (NO) and impaired ..
  62. Molecular Mechanisms Mediating Resistance to Leptin Signaling During Fat Gain
    Virend Somers; Fiscal Year: 2009
    Obesity is associated with increased risk for the development of type 2 diabetes mellitus and cardiovascular disorders...
  63. OBESITY, GLUCOSE METABOLISM AND DIET IN OLDER WOMEN
    ALICE RYAN; Fiscal Year: 2001
    ..The proposed work will provide the candidate with the requisite skills and training to embark on an independent research career. ..
  64. EXERCISE AND ENERGY/SUBSTRATE UTIL IN BLACKS WITH NIDDM
    Dara Schuster; Fiscal Year: 2002
    African Americans (AA) have a 2-3 fold higher prevalence of type 2 diabetes mellitus (DM), greater disease-associated morbidity and mortality and earlier age of onset than Caucasian Americans (CA)...
  65. A novel model of reproductive and metabolic features of polycystic ovary syndrome
    Romana A Nowak; Fiscal Year: 2010
    ....
  66. TREATING PERIODONTAL INFECTION: GLYCEMIC CONTROL
    George Taylor; Fiscal Year: 2002
    ..clinical evidence to suggest that periodontal infection adversely affects glycemic control in people with type 2 diabetes mellitus. The purpose of this project is to establish important preliminary data necessary to support design of a ..