type 1 diabetes mellitus

Summary

Summary: A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.

Top Publications

  1. ncbi Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen
    A M Shapiro
    Surgical Medical Research Institute and the Department of Surgery, University of Alberta, Edmonton, Canada
    N Engl J Med 343:230-8. 2000
  2. ncbi Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: a multicentre prospective registration study
    Christopher C Patterson
    Epidemiology Research Group, Centre for Public Health, Queen s University Belfast, Belfast, UK
    Lancet 373:2027-33. 2009
  3. ncbi Global prevalence of diabetes: estimates for the year 2000 and projections for 2030
    Sarah Wild
    Public Health Sciences, University of Edinburgh, Edinburgh, Scotland
    Diabetes Care 27:1047-53. 2004
  4. ncbi The NOD mouse: a model of immune dysregulation
    Mark S Anderson
    Diabetes Center, University of California, San Francisco, California 94143, USA
    Annu Rev Immunol 23:447-85. 2005
  5. ncbi International trial of the Edmonton protocol for islet transplantation
    A M James Shapiro
    Clinical Islet Transplant Program, University of Alberta, Edmonton, AB, Canada
    N Engl J Med 355:1318-30. 2006
  6. ncbi Mortality and causes of death in the WHO Multinational Study of Vascular Disease in Diabetes
    N J Morrish
    North Bedfordshire Diabetes Centre, Bedford Hospital, UK
    Diabetologia 44:S14-21. 2001
  7. pmc Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes
    David M Nathan
    N Engl J Med 353:2643-53. 2005
  8. ncbi A randomized controlled trial of Sweet Talk, a text-messaging system to support young people with diabetes
    V L Franklin
    Maternal and Child Health Sciences, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
    Diabet Med 23:1332-8. 2006
  9. ncbi Mortality from heart disease in a cohort of 23,000 patients with insulin-treated diabetes
    S P Laing
    Section of Epidemiology, Brookes Lawley Building, Institute of Cancer Research, Cotswold Road, Sutton, Surrey SM2 5NG, UK
    Diabetologia 46:760-5. 2003
  10. ncbi Five-year follow-up after clinical islet transplantation
    Edmond A Ryan
    Department of Medicine, Clinical Islet Transplant Program, 2000 College Plaza, 8215 112th St, Edmonton, Alberta, Canada T6G 2C8
    Diabetes 54:2060-9. 2005

Detail Information

Publications297 found, 100 shown here

  1. ncbi Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen
    A M Shapiro
    Surgical Medical Research Institute and the Department of Surgery, University of Alberta, Edmonton, Canada
    N Engl J Med 343:230-8. 2000
    Registry data on patients with type 1 diabetes mellitus who undergo pancreatic islet transplantation indicate that only 8 percent are free of the need for insulin therapy at one year.
  2. ncbi Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: a multicentre prospective registration study
    Christopher C Patterson
    Epidemiology Research Group, Centre for Public Health, Queen s University Belfast, Belfast, UK
    Lancet 373:2027-33. 2009
    ..We aimed to establish 15-year incidence trends for childhood type 1 diabetes in European centres, and thereby predict the future burden of childhood diabetes in Europe...
  3. ncbi Global prevalence of diabetes: estimates for the year 2000 and projections for 2030
    Sarah Wild
    Public Health Sciences, University of Edinburgh, Edinburgh, Scotland
    Diabetes Care 27:1047-53. 2004
    ..The goal of this study was to estimate the prevalence of diabetes and the number of people of all ages with diabetes for years 2000 and 2030...
  4. ncbi The NOD mouse: a model of immune dysregulation
    Mark S Anderson
    Diabetes Center, University of California, San Francisco, California 94143, USA
    Annu Rev Immunol 23:447-85. 2005
    ..The information gained from this highly relevant model of human disease will lead to potential therapies that may alter the development of the disease and its progression in patients with T1D...
  5. ncbi International trial of the Edmonton protocol for islet transplantation
    A M James Shapiro
    Clinical Islet Transplant Program, University of Alberta, Edmonton, AB, Canada
    N Engl J Med 355:1318-30. 2006
    Islet transplantation offers the potential to improve glycemic control in a subgroup of patients with type 1 diabetes mellitus who are disabled by refractory hypoglycemia...
  6. ncbi Mortality and causes of death in the WHO Multinational Study of Vascular Disease in Diabetes
    N J Morrish
    North Bedfordshire Diabetes Centre, Bedford Hospital, UK
    Diabetologia 44:S14-21. 2001
    ..The low excess mortality in the Japanese cohort could have implications for the possible reduction of the burden of mortality associated with diabetes in other parts of the world...
  7. pmc Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes
    David M Nathan
    N Engl J Med 353:2643-53. 2005
    ..We studied whether the use of intensive therapy as compared with conventional therapy during the Diabetes Control and Complications Trial (DCCT) affected the long-term incidence of cardiovascular disease...
  8. ncbi A randomized controlled trial of Sweet Talk, a text-messaging system to support young people with diabetes
    V L Franklin
    Maternal and Child Health Sciences, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
    Diabet Med 23:1332-8. 2006
    ..To assess Sweet Talk, a text-messaging support system designed to enhance self-efficacy, facilitate uptake of intensive insulin therapy and improve glycaemic control in paediatric patients with Type 1 diabetes...
  9. ncbi Mortality from heart disease in a cohort of 23,000 patients with insulin-treated diabetes
    S P Laing
    Section of Epidemiology, Brookes Lawley Building, Institute of Cancer Research, Cotswold Road, Sutton, Surrey SM2 5NG, UK
    Diabetologia 46:760-5. 2003
    ..The Diabetes UK cohort, essentially one of patients with Type 1 diabetes, now has sufficient follow-up to report all heart disease, and specifically ischaemic heart disease, mortality rates by age...
  10. ncbi Five-year follow-up after clinical islet transplantation
    Edmond A Ryan
    Department of Medicine, Clinical Islet Transplant Program, 2000 College Plaza, 8215 112th St, Edmonton, Alberta, Canada T6G 2C8
    Diabetes 54:2060-9. 2005
    ..The results, though promising, still point to the need for further progress in the availability of transplantable islets, improving islet engraftment, preserving islet function, and reducing toxic immunosuppression...
  11. ncbi The Ins2Akita mouse as a model of early retinal complications in diabetes
    Alistair J Barber
    Penn State Retina Research Group, The Ulerich Ophthalmology Research Laboratory, Penn State College of Medicine, Hershey, 17033, USA
    Invest Ophthalmol Vis Sci 46:2210-8. 2005
    ..Male mice heterozygous for this mutation have progressive loss of beta-cell function, decreased pancreatic beta-cell density, and significant hyperglycemia, as early as 4 weeks of age...
  12. ncbi Vascular complications in diabetes mellitus: the role of endothelial dysfunction
    Casper G Schalkwijk
    Department of Internal Medicine, Academic Hospital Maastricht, The Netherlands
    Clin Sci (Lond) 109:143-59. 2005
    ..Finally, the components of the metabolic syndrome can impair endothelial function...
  13. ncbi beta-Cell death during progression to diabetes
    D Mathis
    Section on Immunology and Immunogenetics, Joslin Diabetes Centre, One Joslin Place, Boston, Massachusetts 02215, USA
    Nature 414:792-8. 2001
    ..beta-Cell apoptosis may also be involved in the occasional evolution of type 2 into type 1 diabetes...
  14. ncbi Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus
    Kevan C Herold
    Naomi Berrie Diabetes Center and the Department of Medicine, Division of Endocrinology, College of Physicians and Surgeons, Columbia University, New York 10032, USA
    N Engl J Med 346:1692-8. 2002
    b>Type 1 diabetes mellitus is a chronic autoimmune disease caused by the pathogenic action of T lymphocytes on insulin-producing beta cells...
  15. ncbi Overweight and the metabolic syndrome in adult offspring of women with diet-treated gestational diabetes mellitus or type 1 diabetes
    Tine D Clausen
    Center for Pregnant Women with Diabetes, Department of Obstetrics, Rigshospitalet, The Capital Region of Denmark, Faculty of Health Sciences, University of Copenhagen, 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 94:2464-70. 2009
    ..In animal studies, exposure to intrauterine hyperglycemia increases the risk of cardiovascular disease through only partly understood epigenetic mechanisms. Human long-term follow-up studies on the same topic are few...
  16. ncbi Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy
    Katalin Susztak
    Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Diabetes 55:225-33. 2006
    ....
  17. ncbi High prevalence of type 2 diabetes and pre-diabetes in adult offspring of women with gestational diabetes mellitus or type 1 diabetes: the role of intrauterine hyperglycemia
    Tine D Clausen
    Department of Obstetrics, Copenhagen Center for Pregnant Women with Diabetes, Copenhagen University Hospital, Rigshospitalet, Denmark
    Diabetes Care 31:340-6. 2008
    ..We studied glucose tolerance in adult offspring of women with either gestational diabetes mellitus (GDM) or type 1 diabetes, taking the impact of both intrauterine hyperglycemia and genetic predisposition to type 2 diabetes into account...
  18. pmc CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope
    Ania Skowera
    Department of Immunobiology, King s College London, London, United Kingdom
    J Clin Invest 118:3390-402. 2008
    ..Our findings suggest that autoreactive CTLs are important targets for immune-based interventions in type 1 diabetes and argue for early, aggressive insulin therapy to preserve remaining beta cells...
  19. pmc Mapping the genetic architecture of gene expression in human liver
    Eric E Schadt
    Rosetta Inpharmatics, Seattle, Washington, United States of America
    PLoS Biol 6:e107. 2008
    ..We also identify SORT1 and CELSR2 as candidate susceptibility genes for a locus recently associated with coronary artery disease and plasma low-density lipoprotein cholesterol levels in the process...
  20. ncbi Long-term mortality in a nationwide cohort of childhood-onset type 1 diabetic patients in Norway
    T Skrivarhaug
    Department of Pediatrics, Ulleval University Hospital, N 0407 Oslo, Norway
    Diabetologia 49:298-305. 2006
    ..We examined long-term total and cause-specific mortality in a nationwide, population-based Norwegian cohort of patients with childhood-onset type 1 diabetes...
  21. ncbi Diabetic nephropathy: diagnosis, prevention, and treatment
    Jorge L Gross
    Endocrine Division, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Diabetes Care 28:164-76. 2005
    ....
  22. ncbi Pathogenesis of type 1 diabetes mellitus: interplay between enterovirus and host
    Didier Hober
    Laboratoire de Virologie EA3610 Pathogenèse Virale du Diabète de Type 1, Faculte de Medecine, Universite Lille 2, CHRU Lille, Centre de Biologie et Pathologie et Institut Hippocrate Parc Eurasanté, Boulevard du Prof J Leclercq, 59037 Lille Cedex, France
    Nat Rev Endocrinol 6:279-89. 2010
    Enteroviruses are believed to contribute to the pathogenesis of type 1 diabetes mellitus (T1DM). In this Review, the interplay between infection with enteroviruses, the immune system and host genes is discussed...
  23. ncbi Hypoglycaemia: the limiting factor in the glycaemic management of Type I and Type II diabetes
    P E Cryer
    Division of Endocrinology, Diabetes and Metabolism, Washington University School of Medicine, St Louis, MO 63110, USA
    Diabetologia 45:937-48. 2002
    ....
  24. ncbi Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation
    B Salomon
    The Committee on Immunology, Ben May Institute for Cancer Research and Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA
    Annu Rev Immunol 19:225-52. 2001
    ..The implications of these complexities and the potential for use of these therapies in clinical immune intervention are discussed...
  25. pmc Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells
    Natalia Martin-Orozco
    Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
    Eur J Immunol 39:216-24. 2009
    ..These results indicate that islet-reactive Th17 cells promote pancreatic inflammation, but only induce IDDM upon conversion into IFN-gamma producers...
  26. ncbi Increased monocytic activity and biomarkers of inflammation in patients with type 1 diabetes
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology, UC Davis Medical Center, Sacramento, CA 95817, USA
    Diabetes 55:774-9. 2006
    ..These results have a major implication on our understanding of the role of inflammation in vasculopathies in type 1 diabetes...
  27. pmc Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes
    Sergey Nejentsev
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 0XY, UK
    Science 324:387-9. 2009
    ..This finding firmly establishes the role of IFIH1 in T1D and demonstrates that resequencing studies can pinpoint disease-causing genes in genomic regions initially identified by GWASs...
  28. ncbi Meta-analysis: glycosylated hemoglobin and cardiovascular disease in diabetes mellitus
    Elizabeth Selvin
    Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA
    Ann Intern Med 141:421-31. 2004
    ..In persons with diabetes, chronic hyperglycemia (assessed by glycosylated hemoglobin level) is related to the development of microvascular disease; however, the relation of glycosylated hemoglobin to macrovascular disease is less clear...
  29. pmc Genome-wide association scan for diabetic nephropathy susceptibility genes in type 1 diabetes
    Marcus G Pezzolesi
    Research Division, Joslin Diabetes Center, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 58:1403-10. 2009
    ..To search for genes that contribute to diabetic nephropathy, a genome-wide association scan was implemented on the Genetics of Kidneys in Diabetes collection...
  30. ncbi The rise of childhood type 1 diabetes in the 20th century
    Edwin A M Gale
    Department of Diabetes and Metabolism, Division of Medicine, University of Bristol, Medical School Unit, Southmead Hospital, Bristol BS10 5NB, U K
    Diabetes 51:3353-61. 2002
    ..The disease process underlying type 1 diabetes has changed over time and continues to evolve. Understanding why and how this produced the pandemic of childhood diabetes would be an important step toward reversing it...
  31. ncbi Telemedical support to improve glycemic control in adolescents with type 1 diabetes mellitus
    Birgit Rami
    Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Waehringer Guertel 18 20, A 1090, Vienna, Austria
    Eur J Pediatr 165:701-5. 2006
    ..feasibility of a telemedical (TM) support program and its effect on glycemic control in adolescents with type 1 diabetes mellitus (T1DM). Thirty-six adolescents (m=20, median age at the start of the study: 15.3 years (range: 10.7-19...
  32. ncbi Glomerular hyperfiltration and the salt paradox in early [corrected] type 1 diabetes mellitus: a tubulo-centric view
    Volker Vallon
    Department of Pharmacology, University of Tubingen, Tubingen, Germany
    J Am Soc Nephrol 14:530-7. 2003
    ..Finally, an outline is presented of potential therapeutic implications for the prevention of diabetic kidney disease...
  33. ncbi Timing of initial cereal exposure in infancy and risk of islet autoimmunity
    Jill M Norris
    Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver 80262, USA
    JAMA 290:1713-20. 2003
    Dietary exposures in infancy have been implicated, albeit inconsistently, in the etiology of type 1 diabetes mellitus (DM).
  34. ncbi The role of T-cells in the pathogenesis of Type 1 diabetes: from cause to cure
    Bart O Roep
    Dept Immunohaematology and Blood Transfusion, E3 Q, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Diabetologia 46:305-21. 2003
    b>Type 1 diabetes mellitus results from a T-cell mediated autoimmune destruction of the pancreatic beta cells in genetically predisposed individuals. The knowledge of the immunopathogenesis has increased enormously in the last two decades...
  35. ncbi Beta-cell function and the development of diabetes-related complications in the diabetes control and complications trial
    Michael W Steffes
    Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Diabetes Care 26:832-6. 2003
    ..Also, continuing C-peptide (insulin) secretion is important in avoiding hypoglycemia (the major complication of intensive diabetic therapy)...
  36. pmc Tissue expression of PD-L1 mediates peripheral T cell tolerance
    Mary E Keir
    Department of Pathology, Brigham and Women s Hospital and Children s Hospital Boston, MA 02115, USA
    J Exp Med 203:883-95. 2006
    ..These data provide evidence that PD-L1 expression on parenchymal cells rather than hematopoietic cells protects against autoimmune diabetes and point to a novel role for PD-1-PD-L1 interactions in mediating tissue tolerance...
  37. pmc Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice
    Chang yun Hu
    Section of Endocrinology, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Invest 117:3857-67. 2007
    ..Our results demonstrate clinical efficacy even in established disease and identify mechanisms for therapeutic action that will guide design and evaluation of parallel studies in patients...
  38. ncbi Increased risk of common infections in patients with type 1 and type 2 diabetes mellitus
    L M A J Muller
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Clin Infect Dis 41:281-8. 2005
    ..We intended to determine the relative risks of common infections in patients with type 1 and type 2 diabetes mellitus (DM1 and DM2, respectively)...
  39. pmc Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus
    Christopher G Bell
    Medical Genomics, UCL Cancer Institute, University College London, London, UK
    BMC Med Genomics 3:33. 2010
    ..of DNA methylation is associated with diabetic nephropathy in a case-control study of 192 Irish patients with type 1 diabetes mellitus (T1D). Cases had T1D and nephropathy whereas controls had T1D but no evidence of renal disease.
  40. pmc Long-term effect of diabetes and its treatment on cognitive function
    Alan M Jacobson
    N Engl J Med 356:1842-52. 2007
    ..Long-standing concern about the effects of type 1 diabetes on cognitive ability has increased with the use of therapies designed to bring glucose levels close to the nondiabetic range and the attendant increased risk of severe hypoglycemia...
  41. ncbi The reliability and validity of a brief diabetes knowledge test
    J T Fitzgerald
    Department of Medical Education, University of Michigan Medical School, Ann Arbor 48109, USA
    Diabetes Care 21:706-10. 1998
    ..To examine the reliability and validity of a brief diabetes knowledge test. The diabetes knowledge test has two components: a 14-item general test and a 9-item insulin-use subscale...
  42. pmc Glycation and carboxymethyllysine levels in skin collagen predict the risk of future 10-year progression of diabetic retinopathy and nephropathy in the diabetes control and complications trial and epidemiology of diabetes interventions and complications p
    Saul Genuth
    Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Diabetes 54:3103-11. 2005
    ..Glycation and subsequent AGE formation may explain the risk of these complications associated with prior A1C and provide a rational basis for the phenomenon of "metabolic memory" in the pathogenesis of these diabetes complications...
  43. ncbi Environmental triggers and determinants of type 1 diabetes
    Mikael Knip
    Hospital for Children and Adolescents, University of Helsinki, P O Box 281, FI 00029 Huch, Helsinki, Finland
    Diabetes 54:S125-36. 2005
    ..Accordingly, progression to clinical type 1 diabetes typically requires the unfortunate combination of genetic disease susceptibility, a diabetogenic trigger, and a high exposure to a driving antigen...
  44. pmc Pathway analysis of seven common diseases assessed by genome-wide association
    Ali Torkamani
    Scripps Genomic Medicine, The Scripps Translational Science Institute, and Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Genomics 92:265-72. 2008
    ..Additionally, we analyze the genetic relationships between the seven diseases, and based upon similarities with respect to the associated genes and pathways affected in each, propose a new way of categorizing the diseases...
  45. ncbi Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes
    Shelley Lindley
    Department of Immunobiology, Guy s, King s and St Thomas School of Medicine, 2nd Floor, New Guy s House, Guy s Hospital London SE1 9RT, UK
    Diabetes 54:92-9. 2005
    ..007) and intracellular CTLA-4 (P = 0.01). These data demonstrate deficiency in function of the CD4(+)CD25(+) Treg population that may influence the pathogenesis of type 1 diabetes...
  46. ncbi Endothelial dysfunction and increased arterial intima-media thickness in children with type 1 diabetes
    Mikko J Jarvisalo
    Department of Clinical Physiology, University of Turku, Turku, Finland
    Circulation 109:1750-5. 2004
    ....
  47. ncbi Prediction of autoantibody positivity and progression to type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY)
    Jennifer M Barker
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Clin Endocrinol Metab 89:3896-902. 2004
    ..Predictive value of autoantibodies increases with blinded duplicate and independent sample retesting and incorporation of the level of autoantibody in the predictive algorithm...
  48. ncbi Vascular risk factors and diabetic neuropathy
    Solomon Tesfaye
    Diabetes Research Unit, Royal Hallamshire Hospital, Sheffield, United Kingdom
    N Engl J Med 352:341-50. 2005
    ..We studied risk factors for the development of distal symmetric neuropathy in 1172 patients with type 1 diabetes mellitus from 31 centers participating in the European Diabetes (EURODIAB) Prospective Complications Study.
  49. ncbi Markers of inflammation are cross-sectionally associated with microvascular complications and cardiovascular disease in type 1 diabetes--the EURODIAB Prospective Complications Study
    M T Schram
    Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Diabetologia 48:370-8. 2005
    ..The pathogenesis of vascular complications in type 1 diabetes is poorly understood, but may involve chronic, low-grade inflammation. We investigated the association of markers of inflammation with vascular complications in type 1 diabetes...
  50. pmc Shared and distinct genetic variants in type 1 diabetes and celiac disease
    Deborah J Smyth
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    N Engl J Med 359:2767-77. 2008
    ..Since both diseases are associated with the HLA class II genes on chromosome 6p21, we tested whether non-HLA loci are shared...
  51. ncbi Increased serum adiponectin levels in type 1 diabetic patients with microvascular complications
    J Frystyk
    Medical Research Laboratories, Clinical Institute and Medical Department M Diabetes and Endocrinology, Aarhus University Hospital, Aarhus C, Denmark
    Diabetologia 48:1911-8. 2005
    ..In type 1 diabetic patients, the relationship between ADPN and the presence of vascular complications is largely unknown...
  52. pmc Physiological beta cell death triggers priming of self-reactive T cells by dendritic cells in a type-1 diabetes model
    Shannon Turley
    Section of Immunology and Immunogenetics, Joslin Diabetes Center and Dept of Medicine, Brigham and Women s Hospital, Harvard Medical School, One Joslin Pl, Boston, MA 02215, USA
    J Exp Med 198:1527-37. 2003
    ....
  53. ncbi Vascular disease and diabetes: is hypoglycaemia an aggravating factor?
    Rohana J Wright
    Department of Diabetes, Royal Infirmary of Edinburgh, UK
    Diabetes Metab Res Rev 24:353-63. 2008
    ..The concept that acute hypoglycaemia could aggravate vascular complications associated with diabetes is discussed in relation to evolving comprehension of the pathogenesis of atherosclerosis and blood vessel disease...
  54. ncbi Schistosoma mansoni antigens modulate the activity of the innate immune response and prevent onset of type 1 diabetes
    Paola Zaccone
    Immunology Division, Department of Pathology, University of Cambridge, Cambridge, GB
    Eur J Immunol 33:1439-49. 2003
    ..Soluble worm and egg antigens increase the numbers of V alpha 14i NKT cells in NOD mice. These effects of schistosome antigens on the innate immune system provide a mechanism for their ability to prevent type 1 diabetes in NOD mice...
  55. ncbi The electrophysiological findings of subclinical neuropathy in patients with recently diagnosed type 1 diabetes mellitus
    S Karsidag
    Institute of Neurological Sciences, Marmara University, Turkey
    Diabetes Res Clin Pract 67:211-9. 2005
    To assess the prevalence of subclinical neuropathy within the first year of type 1 diabetes mellitus, 30 patients and 14 healthy subjects have been studied prospectively...
  56. pmc The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice
    Mohammed Javeed I Ansari
    Laboratory of Immunogenetics and Transplantation, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Exp Med 198:63-9. 2003
    ....
  57. ncbi Assessment of atrial electromechanical delay, diastolic functions, and left atrial mechanical functions in patients with type 1 diabetes mellitus
    Gurkan Acar
    Department of Cardiology, Kahramanmaras Sutcu Imam University, Faculty of Medicine, Kahramanmaras, Turkey
    J Am Soc Echocardiogr 22:732-8. 2009
    ..study was to evaluate atrial electromechanical coupling obtained by tissue Doppler imaging (TDI), left and right ventricular diastolic functions, and left atrial (LA) mechanical functions in patients with type 1 diabetes mellitus (DM-1).
  58. pmc The Wisconsin Epidemiologic Study of Diabetic Retinopathy: XXII the twenty-five-year progression of retinopathy in persons with type 1 diabetes
    Ronald Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
    Ophthalmology 115:1859-68. 2008
    ..To examine the 25-year cumulative progression and regression of diabetic retinopathy (DR) and its relation to various risk factors...
  59. ncbi Antibiotic treatment partially protects against type 1 diabetes in the Bio-Breeding diabetes-prone rat. Is the gut flora involved in the development of type 1 diabetes?
    S Brugman
    Department of Cell Biology, Immunology Section, University Medical Center Groningen, University of Groningen, A Deusinglaan 1, 9713 AV, Groningen, The Netherlands
    Diabetologia 49:2105-8. 2006
    ..This study was designed to investigate the possible relationship between the development of diabetes and the composition of intestinal flora...
  60. pmc CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells
    Weihong Liu
    UCSF Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 203:1701-11. 2006
    ..Finally, we show that CD127 can be used to quantitate T reg cell subsets in individuals with type 1 diabetes supporting the use of CD127 as a biomarker for human T reg cells...
  61. ncbi Vascular endothelial growth factor (VEGF) in children, adolescents and young adults with Type 1 diabetes mellitus: relation to glycaemic control and microvascular complications
    F Chiarelli
    Department of Medicine, University of Chieti, Italy
    Diabet Med 17:650-6. 2000
    ..vascular endothelial growth factor (VEGF) in a large group of children, adolescents and young adults with Type 1 diabetes mellitus to investigate whether increased VEGF concentrations are associated with long-term glycaemic control and ..
  62. ncbi Microalbuminuria and the risk for early progressive renal function decline in type 1 diabetes
    Bruce A Perkins
    Section on Genetics and Epidemiology, Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    J Am Soc Nephrol 18:1353-61. 2007
    ..Together with testing for microalbuminuria, clinical protocols using cystatin C to diagnose early renal function decline and track response to therapeutic interventions should be developed...
  63. ncbi Beta cells are responsible for CXCR3-mediated T-cell infiltration in insulitis
    Simona Frigerio
    Pediatric Immunology, Department of Research and the University Children s Hospital, Basel, Switzerland
    Nat Med 8:1414-20. 2002
    ..In mice deficient for this receptor, the onset of type 1 diabetes is substantially delayed. Thus, in the absence of known etiological agents, CXC receptor 3 represents a novel target for therapeutic interference early in type 1 diabetes...
  64. pmc Significant vitamin D deficiency in youth with type 1 diabetes mellitus
    Britta M Svoren
    Pediatric, Adolescent, and Young Adult Section, Genetics and Epidemiology Section, Joslin Diabetes Center, Boston, MA 02215, USA
    J Pediatr 154:132-4. 2009
    Serum 25-hydroxyvitamin D was measured in 128 youth with type 1 diabetes mellitus. Less than 25% of the patients were vitamin D sufficient...
  65. ncbi Diabetes and gender
    E A Gale
    Diabetes and Metabolism, Division of Medicine, University of Bristol, UK
    Diabetologia 44:3-15. 2001
    ..Women are, however, more likely to transmit Type II diabetes to their offspring. Understanding these experiments of nature might suggest ways of influencing the early course of both forms of the disease...
  66. ncbi Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease
    Karl S Lang
    Institute of Experimental Immunology, University Hospital of Zurich, Schmelzbergstrasse 12, Zurich, Switzerland
    Nat Med 11:138-45. 2005
    ..These data identify the 'inflammatory status' of the target organ as a separate and limiting factor determining the development of autoimmune disease...
  67. pmc Immunomodulation by mesenchymal stem cells: a potential therapeutic strategy for type 1 diabetes
    Reza Abdi
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 57:1759-67. 2008
    ....
  68. pmc The 25-year incidence of visual impairment in type 1 diabetes mellitus the wisconsin epidemiologic study of diabetic retinopathy
    Ronald Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726 2336, USA
    Ophthalmology 117:63-70. 2010
    ..To examine the 25-year cumulative incidence of visual impairment (VI) and its relation to various risk factors...
  69. ncbi Ketosis-prone type 2 diabetes in patients of sub-Saharan African origin: clinical pathophysiology and natural history of beta-cell dysfunction and insulin resistance
    Franck Mauvais-Jarvis
    Department of Endocrinology and Diabetes, Saint Louis Hospital and University of Paris VII School of Medicine, Paris, France
    Diabetes 53:645-53. 2004
    ....
  70. ncbi Evidence for in vivo primed and expanded autoreactive T cells as a specific feature of patients with type 1 diabetes
    Paolo Monti
    Telethon Juvenile Diabetes Research Foundation Center for Beta Cell Replacement, San Raffaele Scientific Institute, Milan, Italy
    J Immunol 179:5785-92. 2007
    ..Prior selection of these cells is possible and is a way to identify diabetes-relevant target Ags and epitopes...
  71. pmc Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction
    Qizhi Tang
    Department of Surgery, University of California, San Francisco, 513 Parnassus Avenue, Box 0540, San Francisco, CA 94143 0540, USA
    Immunity 28:687-97. 2008
    ..Together, these results suggest intra-islet Treg cell dysfunction secondary to defective IL-2 production is a root cause of the progressive breakdown of self-tolerance and the development of diabetes in nonobese diabetic mice...
  72. pmc PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis
    Fabrice Moore
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Brussels, Belgium
    Diabetes 58:1283-91. 2009
    ..We hypothesized that PTPN2 plays a direct role in beta-cell demise and assessed PTPN2 expression in human islets and rat primary and clonal beta-cells, besides evaluating its role in cytokine-induced signaling and beta-cell apoptosis...
  73. ncbi Relation of hemoglobin A1c to left ventricular relaxation in patients with type 1 diabetes mellitus and without overt heart disease
    Mehdi H Shishehbor
    Department of Internal Medicine, Cardiovascular Imaging Center, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Am J Cardiol 91:1514-7, A9. 2003
  74. pmc Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway
    Brian T Fife
    UCSF Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, and Transplantation Research Center, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Exp Med 203:2737-47. 2006
    ....
  75. ncbi Type 1 diabetes
    Denis Daneman
    Division of Endocrinology, Department of Paediatrics, Hospital for Sick Children and University of Toronto, Toronto, ON, Canada M5G 1X8
    Lancet 367:847-58. 2006
    ..Nonetheless, major challenges remain in the development of approaches to the prevention and management of type 1 diabetes and its complications...
  76. pmc Autoreactive CD8 T cells associated with beta cell destruction in type 1 diabetes
    Gabrielle G M Pinkse
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands
    Proc Natl Acad Sci U S A 102:18425-30. 2005
    ..We demonstrate that CD8 T cell autoreactivity is associated with beta cell destruction in type 1 diabetes in humans...
  77. ncbi A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region
    Deborah J Smyth
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2XY, UK
    Nat Genet 38:617-9. 2006
    ..In 4,253 cases, 5,842 controls and 2,134 parent-child trio genotypes, the risk ratio for the minor allele of the nsSNP rs1990760 A --> G (A946T) was 0.86 (95% confidence interval = 0.82-0.90) at P = 1.42 x 10(-10)...
  78. ncbi Clinical outcomes and insulin secretion after islet transplantation with the Edmonton protocol
    E A Ryan
    Department of Medicine, Surgical Medical Research Institute, University of Alberta, Edmonton, Canada
    Diabetes 50:710-9. 2001
    ..An elevation of creatinine appears to be a contraindication to this immunosuppressive regimen. For the subjects who had labile type 1 diabetes that was difficult to control, the risk-to-benefit ratio is in favor of islet transplantation...
  79. pmc Immunotherapy of type 1 diabetes: where are we and where should we be going?
    Xunrong Luo
    Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Immunity 32:488-99. 2010
    ....
  80. pmc A common nonsynonymous single nucleotide polymorphism in the SLC30A8 gene determines ZnT8 autoantibody specificity in type 1 diabetes
    Janet M Wenzlau
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes 57:2693-7. 2008
    ..The type 2 diabetes nonsynonymous single nucleotide polymorphism (SNP) affecting aa(325) lies within the region of highest ZnT8 autoantibody (ZnT8A) binding, prompting an investigation of its relationship to type 1 diabetes...
  81. pmc The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes
    Janet M Wenzlau
    Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, 1775 North Ursula Street, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 104:17040-5. 2007
    ..The combination of bioinformatics and molecular engineering used here will potentially generate other diabetes autoimmunity markers and is also broadly applicable to other autoimmune disorders...
  82. ncbi Caesarean section is associated with an increased risk of childhood-onset type 1 diabetes mellitus: a meta-analysis of observational studies
    C R Cardwell
    Department of Epidemiology and Public Health, School of Medicine and Dentistry, Queen s University Belfast, Grosvenor Road, Belfast, BT12 6BJ, UK
    Diabetologia 51:726-35. 2008
    ....
  83. pmc Cognitive function in children with type 1 diabetes: a meta-analysis
    Patricia A Gaudieri
    Department of Psychiatry, University of Rochester, Rochester, New York, USA
    Diabetes Care 31:1892-7. 2008
    ..To quantify the magnitude and pattern of cognitive difficulties in pediatric type 1 diabetes as well as the effects associated with earlier disease onset and severe hypoglycemia...
  84. ncbi Clinical and genetic characteristics of type 2 diabetes with and without GAD antibodies
    T Tuomi
    Department of Endocrinology, Lund University, Sweden
    Diabetes 48:150-7. 1999
    ..Further, we propose that LADA be defined as GADab positivity (>5 relative units) in patients older than 35 years at onset of type 2 diabetes...
  85. pmc Mature high-affinity immune responses to (pro)insulin anticipate the autoimmune cascade that leads to type 1 diabetes
    Peter Achenbach
    Institut fur Diabetesforschung, Kolner Platz 1, 80804 Munich, Germany
    J Clin Invest 114:589-97. 2004
    ....
  86. ncbi Prolonged QTc interval predicts mortality in patients with Type 1 diabetes mellitus
    P Rossing
    Steno Diabetes Center, Gentofte, Denmark
    Diabet Med 18:199-205. 2001
    ..To evaluate prolonged QTc interval and QT dispersion as predictors of all-cause and cardiovascular mortality after adjustment for well-established risk factors in Type 1 diabetic patients...
  87. ncbi Increased intestinal permeability precedes clinical onset of type 1 diabetes
    E Bosi
    General Medicine, Diabetes and Endocrinology Unit, San Raffaele Scientific Institute and Vita Salute San Raffaele University, Via Olgettina 60, 20132, Milan, Italy
    Diabetologia 49:2824-7. 2006
    ..The aim of this study was to investigate this issue by examining intestinal permeability to sugars in subjects at different stages of type 1 diabetes: preclinical, new-onset and long-term established disease...
  88. pmc Rapamycin monotherapy in patients with type 1 diabetes modifies CD4+CD25+FOXP3+ regulatory T-cells
    Paolo Monti
    Telethon Juvenile Diabetes Research Foundation Center for Beta Cell Replacement, San Raffaele Scientific Institute, Milan, Italy
    Diabetes 57:2341-7. 2008
    ..Preclinical murine models have shown that rapamycin enhances nTreg proliferation and regulatory function also in vivo. Objective of this study was to assess whether rapamycin has in vivo effects on human nTregs...
  89. ncbi Immune therapy for type 1 diabetes mellitus-what is unique about anti-CD3 antibodies?
    Lucienne Chatenoud
    Universite Paris Descartes, INSERM U1013, Hopital Necker Enfants Malades, 161 rue de Sevres, Paris 75015, France
    Nat Rev Endocrinol 6:149-57. 2010
    b>Type 1 diabetes mellitus (T1DM) is a prototypic organ-specific autoimmune disease that results from selective destruction of insulin-secreting beta-cells by immune-mediated inflammation (insulitis), that is, the infiltration of pancreatic ..
  90. ncbi Higher incidence of childhood-onset type 1 diabetes mellitus in remote areas: a UK regional small-area analysis
    C R Cardwell
    School of Medicine and Dentistry, The Queen s University of Belfast, Belfast, UK
    Diabetologia 49:2074-7. 2006
    We investigated the association between the incidence of type 1 diabetes mellitus and remoteness (a proxy measure for exposure to infections) using recently developed techniques for statistical analysis of small-area data.
  91. ncbi Abnormal liver function tests in patients with Type 1 diabetes mellitus: prevalence, clinical correlations and underlying pathologies
    J S Leeds
    Departments of Gastroenterology, Royal Hallamshire Hospital, Sheffield, UK
    Diabet Med 26:1235-41. 2009
    ..Methods Patients with Type 1 diabetes mellitus were prospectively recruited and ALT, glycated haemoglobin and lipid profile were measured...
  92. pmc Tissue-specific remodeling of the mitochondrial proteome in type 1 diabetic akita mice
    Heiko Bugger
    Division of Endocrinology, Metabolism and Diabetes, and Program in Molecular Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Diabetes 58:1986-97. 2009
    ..To elucidate the molecular basis for mitochondrial dysfunction, which has been implicated in the pathogenesis of diabetes complications...
  93. ncbi Autoantibodies to zinc transporter 8 and SLC30A8 genotype stratify type 1 diabetes risk
    P Achenbach
    Diabetes Research Institute of Forschergruppe Diabetes e V, Helmholtz Center Munich, Ingolstaedter Landstr 1, 85764, Neuherberg, Germany
    Diabetologia 52:1881-8. 2009
    ..Our aim was to determine the relationships between autoantibodies to zinc transporter 8 (ZnT8), genotypes of the ZnT8-encoding gene SLC30A8 and type 1 diabetes risk...
  94. pmc Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes
    Matej Oresic
    VTT Technical Research Centre of Finland, Espoo, Finland
    J Exp Med 205:2975-84. 2008
    ..Recognition of these preautoimmune alterations may aid in studies of disease pathogenesis and may open a time window for novel type 1 diabetes prevention strategies...
  95. ncbi Single-donor, marginal-dose islet transplantation in patients with type 1 diabetes
    Bernhard J Hering
    Diabetes Institute for Immunology and Transplantation and Department of Surgery, University of Minnesota, Minneapolis 55455, USA
    JAMA 293:830-5. 2005
    ..However, for islet transplants to become a widespread clinical reality, diabetes reversal must be achieved with a single donor to reduce risks and costs and increase the availability of transplantation...
  96. ncbi The natural killer T-cell ligand alpha-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice
    S Hong
    Howard Hughes Medical Institute, Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Nat Med 7:1052-6. 2001
    ....
  97. ncbi Zonulin upregulation is associated with increased gut permeability in subjects with type 1 diabetes and their relatives
    Anna Sapone
    Mucosal Biology Research Center, University of Maryland School of Medicine, 20 Penn Street, Room 345, Baltimore, MD 21201, USA
    Diabetes 55:1443-9. 2006
    ....
  98. pmc ATP-sensitive K+ channel mediates the zinc switch-off signal for glucagon response during glucose deprivation
    Michela Slucca
    Pacific Northwest Diabetes Research Institute and the Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine and Department of Pharmacology, University of Washington, Seattle, Washington, USA
    Diabetes 59:128-34. 2010
    ..These studies were designed to determine whether closure of the alpha-cell ATP-sensitive K(+) channel (K(ATP) channel) is the mechanism through which the zinc switch-off signal triggers glucagon secretion during glucose deprivation...
  99. ncbi Cumulative incidence of type 1 diabetes in 10,168 siblings of Finnish young-onset type 1 diabetic patients
    Valma Harjutsalo
    Diabetes and Genetic Epidemiology Unit, Department of Epidemiology and Health Promotion, National Public Health Institute, Mannerheimintie 166, FIN 00300, Helsinki, Finland
    Diabetes 54:563-9. 2005
    ..This large prospective family study of type 1 diabetes in siblings of childhood-onset diabetic patients provides reliable empirical estimates for the sibling recurrence risk...
  100. pmc Lipid and lipoprotein profiles in youth with and without type 1 diabetes: the SEARCH for Diabetes in Youth case-control study
    John Guy
    Department of Epidemiology, Colorado School of Public Health, University of Colorado, Denver, Colorado, USA
    Diabetes Care 32:416-20. 2009
    ....
  101. ncbi Familial clustering of autoimmune diseases in patients with type 1 diabetes mellitus
    Juan Manuel Anaya
    Cellular Biology and Immunogenetics Unit, Corporacion para Investigaciones Biologicas, Cra 72 A No 78 B 141, Medellin, Colombia
    J Autoimmun 26:208-14. 2006
    ..familial aggregation of autoimmune diseases (AIDs) among first-degree relatives (FDR) of patients with type 1 diabetes mellitus (T1D)...

Research Grants76

  1. Prevention of Type I Diabetes Mellitus using a Cell Vac*
    Nick Giannoukakis; Fiscal Year: 2002
    ....
  2. Studying the effects of vitamin D on FOXP3 and IL-17 expression in human CD4+ T c
    Insoo Kang; Fiscal Year: 2010
    ..The results of the studies will advance our knowledge on how vitamin D can be used as a therapeutic agent to improve inflammation in humans. ..
  3. The voltage-gated Kv1.3 channel in psoriatic disease: A novel therapeutic target
    Siba P Raychaudhuri; Fiscal Year: 2012
    ..3+ lymphocytes pre and post treatment in the transplanted skin. The overall goal of this proposal is to determine whether Kv1.3 blockade constitutes a potential new therapeutic approach to the treatment of psoriasis. ..
  4. Autoimmunity Center of Excellence - Rochester
    R John Looney; Fiscal Year: 2013
    ..Therefore, we propose inhibiting CXCL13 using a human monoclonal antibody. The primary clinical outcome will again be adverse events. The primary mechanistic outcome will be changes in peripheral blood memory B cells. ..
  5. K-Channels in Lymphocyte Function and Autoimmunity
    GEORGE KANIANTHARA CHANDY; Fiscal Year: 2012
    ..Our strategy is to selectively target voltage-gated Kv1.3 potassium channels in effector memory T cells that are important mediators of autoimmune diseases. ..
  6. Synergistic Roles of Adiponectin & PPARgamma in Beta-Cell Survival/Proliferation
    William L Holland; Fiscal Year: 2010
    ..The PANIC ATTAC mouse allows the unique opportunity to evaluate beta cell regeneration following the cell specific and titratable induction of apoptosis. ..
  7. Epidemiology of Retinopathy and other Complications in Long Term Type 1 Diabetes
    Michael Y Tsai; Fiscal Year: 2013
    ..and Other Complications in Long Term Type 1 Diabetes Project Summary / Abstract Persons with long term type 1 diabetes mellitus (T1DM) are at high risk of developing severe complications, presenting a pressing need to prevent these ..
  8. AUTOIMMUNITY CENTER OF EXCELLENCE
    David Wofsy; Fiscal Year: 2013
    ..focuses primarily on three of these diseases (systemic lupus erythematosus, multiple sclerosis, and type 1 diabetes mellitus), but we also describe active programs in several other autoimmune diseases, including rheumatoid ..
  9. mt-Nd2 and Resistance to Autoimmune Diabetes
    Clayton E Mathews; Fiscal Year: 2013
    ..The studies, as proposed, will provide meaningful data on both the early apoptotic signals that result in human beta cell death as well as insights into how ND2a protects human beta cells. ..
  10. Intracellular Targeting of Proinflammatory Pathways to Ameliorate Type 1 Diabetes
    Daniel J Moore; Fiscal Year: 2010
    ..We will test new pathways in T1D development and apply innovative approaches to target these pathways to reveal new strategies for prevention and reversal of this devastating illness. ..
  11. The Insulin/IGF-I Axis in Diabetic Osteopathy
    John L Fowlkes; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Type 1 diabetes mellitus (T1D) is associated with several disorders of skeletal health, including decreased bone mineral density (BMD) and an increased risk for osteoporosis and fragility fracture...
  12. Role of macrophages in pancreatic islet graft rejection
    Midhat H Abdulreda; Fiscal Year: 2013
    ..provided by candidate): Pancreatic islet transplantation has emerged as a promising therapy for type 1 diabetes mellitus (T1D)...
  13. Modulation of Autoimmune Diabetes by N-acetyl-D-glucosamine Specific B cells
    BRIAN L DIZON; Fiscal Year: 2010
    ..Understanding the mechanisms involved in this link may provide insight on new strategies for earlier diagnosis, treatments, and prevention of T1D. ..
  14. Mechanism for Reduced Adrenomedullary Epinephrine Release in Type 1 Diabetes
    BRANLY OSVALDO ORBAN; Fiscal Year: 2012
    ..underlying the normal counter-regulatory response (CRR) to acute hypoglycemia is largely absent in type 1 diabetes mellitus (T1DM)...
  15. The Role of Toll-Like Receptor-3 in T1D and Efficacy of a Novel Therapeutic
    Kelly McCall; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Type 1 Diabetes Mellitus (T1D) is an autoimmune disorder in which pancreatic beta ([unreadable]) cells, which produce insulin, are mistaken as foreign by one's own immune system and gradually ..
  16. mt-Nd2 and Resistance to Autoimmune Diabetes
    Clayton E Mathews; Fiscal Year: 2011
    ..The studies, as proposed, will provide meaningful data on both the early apoptotic signals that results in beta cell death as well as insights into how ND2a protects beta cells. ..
  17. PETS-D: Parent Education Through Simulation-Diabetes
    Susan Sullivan-Bolyai; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Type 1 diabetes mellitus (T1DM) is the most common metabolic disorder in childhood with an incidence of approximately 1.7 per 1000 children under the age of 20...
  18. Mechanisms of Immunosuppressive Actions of Glucocorticoids
    Inez Rogatsky; Fiscal Year: 2011
    ..abstract_text> ..
  19. Molecular Phenotyping of NOD Mice
    Ivan C Gerling; Fiscal Year: 2010
    ..With a better understanding of these processes it will be possible to develop interventions that prevents this disease. ..
  20. A Novel Therapy for Restricted Induction of Tolerance to Treat Diabetes Mellitus
    Kanneganti Murthy; Fiscal Year: 2013
    ..approach to arrest pancreatic islet injury and restore specific immune tolerance in new-onset Type 1 diabetes mellitus (T1D)...
  21. Improving the Kinetics and Reliability of Continuous Glucose Monitoring
    Brett D Mensh; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Patients with type 1 diabetes mellitus (T1DM) will experience dramatic improvements in their quality of life and life expectancy when the goal of engineering an artificial pancreas is finally realized...
  22. Dendritic Cells in the Breaking of Peripheral Tolerance in Type 1 Diabetes
    JONATHAN DAVID KATZ; Fiscal Year: 2012
    ....
  23. Use of Continuous Glucose Sensors in Adolescents with Inadequate Diabetic Control
    Tim Wysocki; Fiscal Year: 2013
    Project Abstract Management of type 1 diabetes mellitus (T1DM) in adolescents is very difficult and innovative approaches are needed to help them achieve better glycemic control and behavioral outcomes...
  24. RA-Related Autoantibodies in Healthy FDR of RA Patients
    Jill M Norris; Fiscal Year: 2011
    ..Analysis of another autoimmune disease, Type 1 Diabetes Mellitus (DM), has shown that the majority of individuals ultimately affected with that particular disease exhibit ..
  25. Novel Design of a Fast-On/Fast-Off Insulin Analog for Closed-Loop Systems
    BRUCE HILL FRANK; Fiscal Year: 2013
    ..and feedback-based control algorithm-provide a promising technology to enable tight glycemic control in Type 1 diabetes mellitus with improved patient convenience and compliance...
  26. Role of Deoxyhypusine Synthase in the Pathogenesis of Type 1 Diabetes
    STEPHANIE CHESTNUT COLVIN; Fiscal Year: 2013
    ..The research aspect of this proposal will focus on the role of the enzyme deoxyhypusine synthase (DHS) in type 1 diabetes mellitus (T1DM) pathogenesis...
  27. Tissue-Specific Metabolic Reprogramming in Diabetic Complications
    Subramaniam Pennathur; Fiscal Year: 2011
    ..changes in metabolite levels and flux in complications-prone tissues in animal models and patients with type 1 diabetes mellitus and to determine how the metabolite changes reflect altered levels or activities of specific proteins and ..
  28. Fas pathway in organ-specific tolerance and autoimmunity
    ABDEL HAMAD; Fiscal Year: 2010
    ..Identifying the mechanisms by which blockade of the Fas pathway prevents autoimmune diabetes in animal models could prove useful in developing new therapeutic strategies for T1D. ..
  29. Small Molecules Targeting Allele Specific MHC Class II Presentation
    Aaron W Michels; Fiscal Year: 2013
    ....
  30. IMPACT OF PLASMACYTOID DENDRITIC CELLS ON TYPE I DIABETES PATHOGENESIS
    Melissa Swiecki; Fiscal Year: 2013
    ....
  31. Pancreas Imaging by Pretargeting the Islet Beta Cells
    Guozheng Liu; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Type 1 diabetes mellitus (T1DM) is characterized by and Type 2 diabetes mellitus (T2DM) is also involved in the loss of insulin-..
  32. Array development of anti-inflammatory peptoid-graft polymers for islet delivery
    Matthew Webber; Fiscal Year: 2013
    ..surrounding islet transplantation with new materials could improve current strategies to treat type 1 diabetes mellitus. To date, new strategies have focused on limiting the activation of immune cells or preventing blood-..
  33. Determining the rap1b signaling pathway to integrin activation in platelets
    LUIS ALBERTO PANIAGUA; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Type 1 diabetes mellitus (T1DM) arises through autoimmune destruction of pancreatic [unreadable] cells and results in life-long dependency on daily insulin injection...
  34. Role of chemokines in diabetes
    Sergio A Lira; Fiscal Year: 2013
    ..We anticipate that blocking entry of inflammatory cells into the pancreas will prevent destruction of the insulin-producing cells;our work may thus prompt the generation of novel treatments for Type I diabetes. ..
  35. Role of Novel T Cell Costimulatory Pathways in Allograft Rejection and Tolerance
    Mohamed H Sayegh; Fiscal Year: 2011
    ..Overall, our studies should yield useful new data that may lead to development of novel strategies to induce tolerance to islet alloarafts to translate to orimates and humans. ..
  36. Endocrine pancreatic cell regeneration from bone marrow
    Mehboob A Hussain; Fiscal Year: 2010
    Curative treatment of type 1 diabetes mellitus by islet transplantation is limited by insufficient numbers of donor organs. Alternative sources for pancreatic cells may circumvent this problem...
  37. Immunization against Atherosclerosis
    Guoxing Zheng; Fiscal Year: 2012
    ..In addition, this study will further define the role of athero-specific Treg in controlling atherosclerosis and provide useful insights pertaining to targeting these Treg optimally. ..
  38. Visual Sonics Vevo 2100 Imaging System
    Karen H Martin; Fiscal Year: 2010
    ..atherosclerosis and to measure pathological changes in cardiac contractile performance in mouse models of type 1 diabetes mellitus. Researchers from the Center for Neuroscience will use the Vevo to deliver expression vectors into the ..
  39. Diabetes suppresses sympathetic neurotransmission and thereby glucagon secretion
    Gerald J Taborsky; Fiscal Year: 2013
    ....
  40. Type 1 Diabetes and Depression: Role of Brain Glutamate
    Nicolas R Bolo; Fiscal Year: 2013
    ..focused on elucidating the relationship between the perturbations in glucose metabolism associated with type 1 diabetes mellitus (T1DM) and the higher prevalence of major depressive episodes in this patient population...
  41. Ion Channels and Pumps: The Machinery of Electric Signaling at Corneal Wounds
    Min Zhao; Fiscal Year: 2013
    ..How the endogenous EFs are generated and regulated is not known. In streptozotocin (STZ)- induced type 1 diabetes mellitus rats and Pax6+/- mutant mice that have defective corneal wound healing, we observed significantly reduced ..
  42. 18F-Fallypride Micropet Imaging to Monitor Pancreatic Beta Cell Loss in Diabetes
    Adriana Garcia; Fiscal Year: 2010
    ..Aim-3: Measure [unreadable]-cell mass in pancreas during the spontaneous age-dependent development of DM in BB rats and in BB rats treated with the Kv1.3 blocker PAP-1. ..
  43. Artificial pancreas to address missed insulin doses during snacking in adolescent
    SUSAN M DEMARTINI; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Type 1 diabetes mellitus (T1DM) results from permanent loss of insulin secretion...
  44. IFN-Gamma Gene Regulation in T Cells and NK Cells
    Thomas M Aune; Fiscal Year: 2013
    ....
  45. Molecular Studies of the Roles and Regulations of the v-ATPase V0 Sector
    Florante A Quiocho; Fiscal Year: 2010
    ..Other disorders associated with defects in these components include type 1 diabetes mellitus due to mutations of subunit a and osteoporosis owing to mutations of subunit d.
  46. Continuous Glucose Monitoring with Graphene-Based Disposable Wireless Sensors
    GARY D HAVEY; Fiscal Year: 2013
    ..AME has assembled an excellent team to develop this sensor and readout capabilities. In phase II, production prototype sensors and readout electronics will be built and tested on a patient population. ..
  47. In vivo assessment of T cell kinetics in individuals at risk for Type 1 diabetes
    Carla J Greenbaum; Fiscal Year: 2013
    ..Specific Aims: Aim 1: To determine whether altered T cell kinetics is present prior to diagnosis in individuals at risk for type 1 diabetes. Aim 2: To determine the changes in T cell kinetics over time. ..
  48. Identify Driving Risk Factors in T1DM and their Reduction via Behav Intervention
    DANIEL JOSEPH COX; Fiscal Year: 2012
    ..While Type 1 Diabetes Mellitus (T1DM) drivers have over twice as many driving mishaps as non-diabetic drivers, this is accounted for by ..
  49. Immunomodulation Requirements for Treg Immunotherapy for autoimmune diabetes
    ALLISON LORAYNE BAYER; Fiscal Year: 2013
    ..abstract_text> ..
  50. BIOCHEMICAL MECHANISM OF BETA-CELL DESTRUCTION
    John A Corbett; Fiscal Year: 2012
    ....
  51. FL3X: An Adaptive Intervention to Improve Outcomes for Youth with Type 1 Diabetes
    Michael Seid; Fiscal Year: 2012
    ..diabetes self-management is key to maintaining euglycemia and reducing the morbidities associated with type 1 diabetes mellitus (T1D)...
  52. Genome Wide Association Study of Latent Autoimmune Diabetes in Adults
    Struan F A Grant; Fiscal Year: 2013
    ..Variants with equal effects in both AA and Caucasians may represent more universally important genes and pathways for diagnosis and prevention/treatment of diabetes as a whole. ..
  53. Bruton's Tyrosine Kinase and Immune Tolerance in Type 1 Diabetes
    Peggy L Kendall; Fiscal Year: 2013
    ..These discoveries will provide new avenues of intervention for the specific targeting of autoreactive, pathogenic B cells. ..
  54. Exploring CBT-DM's Absoulte and Relative Efficacy for Depressed T1DM Latino Youth
    Eduardo Cumba; Fiscal Year: 2013
    ..entails the revision of the 12-session Group Cognitive Behavioral Therapy (CBT-DM) manual for depressed Type 1 Diabetes Mellitus (T1DM) Latino youth, and explores both the absolute efficacy of CBT-DM against a treatment as usual (TAU) ..
  55. Lipid Mediators in Pancreatic Islet Dysfunction
    Jerry L Nadler; Fiscal Year: 2010
    ..The findings should provide new methods to preserve beta-cell mass ultimately leading to new therapeutic modalities to prevent T1DM and improve ability to reverse T1DM using islet transplantation. ..
  56. Environment, innate immunity and type 1 diabetes
    Li Wen; Fiscal Year: 2013
    ..In turn, this may help to direct investigation in people genetically susceptible to diabetes and aid development of new strategies for prevention and treatment of type 1 diabetes. ..
  57. Epigenetic Mechanisms of Diabetic Metabolic Memory as Studies in Adult Zebrafish
    ROBERT VICTOR INTINE; Fiscal Year: 2012
    ..In the long term, these experiments will provide a foundation for the identification of appropriate targets for new treatments to prevent or reverse diabetic complications. ..
  58. B-lymphocyte Targeting Therapies for Autoimmune Diabetes
    David V Serreze; Fiscal Year: 2013
    ....
  59. Dissecting Dendritic Cell Function in Autoimmune Diabetes
    JONATHAN DAVID KATZ; Fiscal Year: 2013
    ..Aim 2: To determine if NKT cell-produced INF-9 and pDC-produced IDO establish a regulatory circuit that controls diabetogenic T cells in vivo. ..
  60. "Regulatory 'T'Cell Control of Autoimmune Diabetes".
    Qizhi Tang; Fiscal Year: 2013
    ..The insight gained from these mechanistic studies will help to improve the design of regulatory T cell-based therapy for patients and to identify new targets for therapeutic intervention of type 1 diabetes. ..
  61. A pilot study of moderate hyperbilirubinemia in type 1 diabetes mellitus
    Todd Perlstein; Fiscal Year: 2011
    ..treatment strategy of inducing moderate hyperbilirubinemia for preventing the vascular complications of type 1 diabetes mellitus (T1DM)...
  62. UCSF Trialnet: A Phase II Trial of Imatimib in New Onset Type I Diabetes
    Stephen E Gitelman; Fiscal Year: 2013
    ..with the ultimate long-term objectives to better understand the natural history and pathogenesis of type 1 diabetes mellitus (T1D), and to develop therapies to preserve endogenous insulin secretion in those with new onset T1D, and ..
  63. Eating Disorders in Type 1 Diabetes: Mechanisms of Comorbidity
    Rhonda M Merwin; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Individuals with type 1 diabetes mellitus (T1D) who develop an eating disorder are at high risk for diabetes- related medical complications and premature death...
  64. Pediatric Type 1 diabetes: Intervention Trials With Glucagon Suppressors
    Rubina A Heptulla; Fiscal Year: 2010
    b>Type 1 diabetes mellitus (T1DM) is currently managed using modulation of dietary carbohydrates and insulin. Paradoxical post-meal hyperglucagonemia is associated with post-prandial hyperglycemia in T1DM...
  65. REGULATION OF DIABETES BY CHEMOKINES
    Linda Bradley; Fiscal Year: 2001
    ..Identifying the role of chemokines in diabetes will provide new insights into regulation of the disease process. ..
  66. Anti-apoptotic gene therapy: Islet allotransplantation
    Nick Giannoukakis; Fiscal Year: 2002
    DESCRIPTION (provided by applicant) Type 1 diabetes mellitus, also termed insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease that specifically targets the pancreatic beta cells of the islets of Langerhans in a T-..
  67. TERTIARY LYMPHOID ORGANS IN TYPE I DIABETES MELLITUS
    NANCY RUDDLE; Fiscal Year: 2003
    ..Understanding how islet tertiary lymphoid organs are established and function will allow identification of therapeutic targets for determinant spreading and tissue damage in IDDM. ..
  68. IGF binding protein-3 in beta cell apoptosis
    ROBERT FERRY JR; Fiscal Year: 2005
    Autoimmune and non-immune apoptosis, or programmed death, of pancreatic beta cells results in type 1 diabetes mellitus. Normal beta-cell survival entails complex regulation of multiple hormones and fundamental growth factors, including ..
  69. Clinical Testing of an Insulin Analog
    Michael Weiss; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The central goal of insulin replacement therapy in the treatment of Type 1 diabetes mellitus (T1DM) is tight control of blood glucose concentration...
  70. POLY(ADP) RIBOSE SYNTHETASE AND AUTOIMMUNE DIABETES
    Jon Mabley; Fiscal Year: 2000
    ....
  71. Spleen regulation of beta-cell regeneration
    Anita Chong; Fiscal Year: 2007
    ..by applicant): Autoimmune-mediated destruction of [unreadable]-cells is the predominant cause of Type 1 diabetes mellitus (T1 DM)...
  72. Gene-engineered dendritic cell therapy for diabetics
    Massimo Trucco; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Type 1 diabetes mellitus is an autoimmune disease whose etiopathogenesis lies in the selective destruction of the insulin-producing beta cells of the islets of Langerhans in the pancreas...
  73. Gene-engineered dendritic cell therapy for diabetics
    Massimo Trucco; Fiscal Year: 2003
    b>Type 1 diabetes mellitus is an autoimmune disease whose etiopathogenesis lies in the selective destruction of the insulin-producing beta cells of the islets of Langerhans in the pancreas...
  74. Gene transfer with A20 to improve islet transplantation
    Christiane Ferran; Fiscal Year: 2003
    ..This will overcome the requirement for high numbers of islets and the need for intensive immunosuppression. Beneficial results would pave the way for pre-clinical (primates) and clinical applications. ..
  75. Genetics of Virus-Induced Autoimmunity in BB Rats
    JOHN MORDES; Fiscal Year: 2007
    ..The work we propose, identifying the Iddm17 gene, has the potential to contribute importantly to the goals of both of those endeavors. ..
  76. PROTHYMOCYTES AND DIABETES MELLITUS IN BB/W RATS
    Dale Greiner; Fiscal Year: 2003
    ....