prediabetic state

Summary

Summary: The time period before the development of symptomatic diabetes. For example, certain risk factors can be observed in subjects who subsequently develop INSULIN RESISTANCE as in type 2 diabetes (DIABETES MELLITUS, TYPE 2).

Top Publications

  1. pmc Diabetes and pre-diabetes are associated with cardiovascular risk factors and carotid/femoral intima-media thickness independently of markers of insulin resistance and adiposity
    David Faeh
    Institute of Social and Preventive Medicine IUMSP, University Hospital Center and University of Lausanne, Bugnon 17, 1005 Lausanne, Switzerland
    Cardiovasc Diabetol 6:32. 2007
  2. pmc Prevalence of diabetes and high risk for diabetes using A1C criteria in the U.S. population in 1988-2006
    Catherine C Cowie
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Diabetes Care 33:562-8. 2010
  3. pmc Trajectories of glycaemia, insulin sensitivity, and insulin secretion before diagnosis of type 2 diabetes: an analysis from the Whitehall II study
    Adam G Tabák
    Department of Epidemiology and Public Health, University College London, London, UK
    Lancet 373:2215-21. 2009
  4. pmc Full accounting of diabetes and pre-diabetes in the U.S. population in 1988-1994 and 2005-2006
    Catherine C Cowie
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Diabetes Care 32:287-94. 2009
  5. ncbi High prevalence of type 2 diabetes and pre-diabetes in adult offspring of women with gestational diabetes mellitus or type 1 diabetes: the role of intrauterine hyperglycemia
    Tine D Clausen
    Department of Obstetrics, Copenhagen Center for Pregnant Women with Diabetes, Copenhagen University Hospital, Rigshospitalet, Denmark
    Diabetes Care 31:340-6. 2008
  6. ncbi Pre-diabetes and the risk for cardiovascular disease: a systematic review of the evidence
    Earl S Ford
    Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    J Am Coll Cardiol 55:1310-7. 2010
  7. ncbi Prevalence and projections of diabetes and pre-diabetes in adults in Sri Lanka--Sri Lanka Diabetes, Cardiovascular Study (SLDCS)
    P Katulanda
    Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, UK
    Diabet Med 25:1062-9. 2008
  8. pmc Impaired glycemia and diabetic polyneuropathy: the OC IG Survey
    Peter J Dyck
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
    Diabetes Care 35:584-91. 2012
  9. ncbi Prevalence of polyneuropathy in pre-diabetes and diabetes is associated with abdominal obesity and macroangiopathy: the MONICA/KORA Augsburg Surveys S2 and S3
    Dan Ziegler
    Institute for Clinical Diabetes Research, German Diabetes Center, Leibniz Institute at the Heinrich Heine University, Dusseldorf, Germany
    Diabetes Care 31:464-9. 2008
  10. ncbi HbA1c 5·7-6·4% and impaired fasting plasma glucose for diagnosis of prediabetes and risk of progression to diabetes in Japan (TOPICS 3): a longitudinal cohort study
    Yoriko Heianza
    Department of Internal Medicine, University of Tsukuba Institute of Clinical Medicine, Ibaraki, Japan
    Lancet 378:147-55. 2011

Detail Information

Publications252 found, 100 shown here

  1. pmc Diabetes and pre-diabetes are associated with cardiovascular risk factors and carotid/femoral intima-media thickness independently of markers of insulin resistance and adiposity
    David Faeh
    Institute of Social and Preventive Medicine IUMSP, University Hospital Center and University of Lausanne, Bugnon 17, 1005 Lausanne, Switzerland
    Cardiovasc Diabetol 6:32. 2007
    ..Our aim was to examine whether these associations are mediated by body mass index (BMI), waist circumference (waist) or fasting serum insulin (insulin) in a population in the African region...
  2. pmc Prevalence of diabetes and high risk for diabetes using A1C criteria in the U.S. population in 1988-2006
    Catherine C Cowie
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Diabetes Care 33:562-8. 2010
    ..CONCLUSIONS Although A1C detects much lower prevalences than glucose criteria, hyperglycemic conditions remain high in the U.S., and elderly and minority groups are disproportionately affected...
  3. pmc Trajectories of glycaemia, insulin sensitivity, and insulin secretion before diagnosis of type 2 diabetes: an analysis from the Whitehall II study
    Adam G Tabák
    Department of Epidemiology and Public Health, University College London, London, UK
    Lancet 373:2215-21. 2009
    ..We aimed to characterise trajectories of fasting and postload glucose, insulin sensitivity, and insulin secretion in individuals who develop type 2 diabetes...
  4. pmc Full accounting of diabetes and pre-diabetes in the U.S. population in 1988-1994 and 2005-2006
    Catherine C Cowie
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Diabetes Care 32:287-94. 2009
    ..S. during 2005-2006. We then compared the prevalences of these conditions with those in 1988-1994...
  5. ncbi High prevalence of type 2 diabetes and pre-diabetes in adult offspring of women with gestational diabetes mellitus or type 1 diabetes: the role of intrauterine hyperglycemia
    Tine D Clausen
    Department of Obstetrics, Copenhagen Center for Pregnant Women with Diabetes, Copenhagen University Hospital, Rigshospitalet, Denmark
    Diabetes Care 31:340-6. 2008
    ..We studied glucose tolerance in adult offspring of women with either gestational diabetes mellitus (GDM) or type 1 diabetes, taking the impact of both intrauterine hyperglycemia and genetic predisposition to type 2 diabetes into account...
  6. ncbi Pre-diabetes and the risk for cardiovascular disease: a systematic review of the evidence
    Earl S Ford
    Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    J Am Coll Cardiol 55:1310-7. 2010
    ..Our objective was to estimate the magnitude of the relative risk (RR) for cardiovascular disease associated with impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) from published prospective observational studies...
  7. ncbi Prevalence and projections of diabetes and pre-diabetes in adults in Sri Lanka--Sri Lanka Diabetes, Cardiovascular Study (SLDCS)
    P Katulanda
    Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, UK
    Diabet Med 25:1062-9. 2008
    ..Projections for the year 2030 and factors associated with diabetes and pre-diabetes are also presented...
  8. pmc Impaired glycemia and diabetic polyneuropathy: the OC IG Survey
    Peter J Dyck
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
    Diabetes Care 35:584-91. 2012
    ....
  9. ncbi Prevalence of polyneuropathy in pre-diabetes and diabetes is associated with abdominal obesity and macroangiopathy: the MONICA/KORA Augsburg Surveys S2 and S3
    Dan Ziegler
    Institute for Clinical Diabetes Research, German Diabetes Center, Leibniz Institute at the Heinrich Heine University, Dusseldorf, Germany
    Diabetes Care 31:464-9. 2008
    ..The aim of this study was to determine the prevalence and risk factors of polyneuropathy in subjects with diabetes, impaired fasting glucose (IFG), impaired glucose tolerance (IGT), or normal glucose tolerance (NGT)...
  10. ncbi HbA1c 5·7-6·4% and impaired fasting plasma glucose for diagnosis of prediabetes and risk of progression to diabetes in Japan (TOPICS 3): a longitudinal cohort study
    Yoriko Heianza
    Department of Internal Medicine, University of Tsukuba Institute of Clinical Medicine, Ibaraki, Japan
    Lancet 378:147-55. 2011
    ....
  11. ncbi High-fat diet induced neuropathy of pre-diabetes and obesity: effects of "healthy" diet and aldose reductase inhibition
    Irina G Obrosova
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Diabetes 56:2598-608. 2007
    ..This study evaluated neuropathic changes and their amenability to dietary and pharmacological interventions in mice fed a high-fat diet (HFD), a model of pre-diabetes and alimentary obesity...
  12. pmc Increased arterial stiffness in healthy subjects with high-normal glucose levels and in subjects with pre-diabetes
    Jin Young Shin
    Department of Family Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
    Cardiovasc Diabetol 10:30. 2011
    ..The purpose of this study is to investigate the relationship between FPG and arterial stiffness in non-diabetic healthy subjects...
  13. pmc Impact of A1C screening criterion on the diagnosis of pre-diabetes among U.S. adults
    Devin M Mann
    Department of Medicine, Division of General Internal Medicine, Mount Sinai School of Medicine, New York, New York, USA
    Diabetes Care 33:2190-5. 2010
    ..New clinical practice recommendations include A1C as an alternative to fasting glucose as a diagnostic test for identifying pre-diabetes. The impact of these new recommendations on the diagnosis of pre-diabetes is unknown...
  14. pmc Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity
    Oded Shaham
    Broad Institute of MIT and Harvard, Cambridge, MA, USA
    Mol Syst Biol 4:214. 2008
    ..Our findings lay the groundwork for using metabolic profiling to define an individual's 'insulin response profile', which could have value in predicting diabetes, its complications, and in guiding therapy...
  15. ncbi Diabetes prevention in a faith-based setting: results of translational research
    John Mark Boltri
    Department of Family Medicine, Mercer University School of Medicine and the Medical Center of Central Georgia, Macon, Georgia 31206, USA
    J Public Health Manag Pract 14:29-32. 2008
    ..The purpose of this study was to translate the National Institutes of Health (NIH)-Diabetes Prevention Program (DPP) into a church-based setting...
  16. ncbi Prevention of diabetes and reduction in major cardiovascular events in studies of subjects with prediabetes: meta-analysis of randomised controlled clinical trials
    Ingrid Hopper
    Department of Clinical Pharmacology, Alfred Hospital, Melbourne, Australia
    Eur J Cardiovasc Prev Rehabil 18:813-23. 2011
    ..We therefore sought to determine whether interventions (including diet, exercise and pharmacological therapy), altered all-cause and cardiovascular related mortality in such subjects...
  17. ncbi Hypomagnesaemia is associated with diabetes: Not pre-diabetes, obesity or the metabolic syndrome
    David Simmons
    Institute of Metabolic Science, Cambridge University Hospitals NHS Foundation Trust, UK
    Diabetes Res Clin Pract 87:261-6. 2010
    ..The mechanism for the association between diabetes and hypomagnesaemia remains uncertain. This study aimed to test whether hypomagnesaemia is present in pre-diabetes, obesity and the metabolic syndrome...
  18. ncbi Animal models of type 2 diabetes: clinical presentation and pathophysiological relevance to the human condition
    William T Cefalu
    Division of Nutrition and Chronic Diseases, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
    ILAR J 47:186-98. 2006
    ..Progression of the disease from prediabetic state to overt diabetes and the development of complications occur over many years...
  19. ncbi Pathophysiology of prediabetes and treatment implications for the prevention of type 2 diabetes mellitus
    Michael Bergman
    Department of Medicine, Division of Endocrinology, NYU School of Medicine, 345 East 37th Street, Suite 313, New York, NY 10016, USA
    Endocrine 43:504-13. 2013
    ....
  20. pmc Insulin sensitivity is reflected by characteristic metabolic fingerprints--a Fourier transform mass spectrometric non-targeted metabolomics approach
    Marianna Lucio
    Department of BioGeoChemistry and Analytics, Institute for Ecological Chemistry, Helmholtz Zentrum Muenchen German Research Center for Environmental Health, Neuherberg, Germany
    PLoS ONE 5:e13317. 2010
    ....
  21. pmc Identifying dysglycemic states in older adults: implications of the emerging use of hemoglobin A1c
    Kasia J Lipska
    Robert Wood Johnson Clinical Scholars Program, Yale University School of Medicine, P O Box 208088, 333 Cedar Street, SHM IE 61, New Haven, Connecticut 06520 8088, USA
    J Clin Endocrinol Metab 95:5289-95. 2010
    ..Hemoglobin A1c (A1c) was recently added to the diagnostic criteria for diabetes and prediabetes...
  22. ncbi Susceptibility to fatty acid-induced β-cell dysfunction is enhanced in prediabetic diabetes-prone biobreeding rats: a potential link between β-cell lipotoxicity and islet inflammation
    Christine Tang
    Department of Physiology, University of Toronto, Room 3336, Medical Sciences Building, Toronto, Ontario, Canada M5S 1A8
    Endocrinology 154:89-101. 2013
    ..In conclusion, the presence of insulitis was permissive for IH-induced β-cell dysfunction in the BB rat, which suggests a link between β-cell lipotoxicity and islet inflammation...
  23. pmc Impact of ADMA, endothelial progenitor cells and traditional cardiovascular risk factors on pulse wave velocity among prediabetic individuals
    Ioannis Protopsaltis
    Diabetes Center, Tzanio General Hospital of Piraeus, Zanni and Afendouli 1, Piraeus 18537, Greece
    Cardiovasc Diabetol 11:141. 2012
    ..The correlations of novel and traditional cardiovascular risk factors with central arterial stiffness in prediabetic individuals were investigated in the present study...
  24. ncbi Therapy insight: neurological complications of prediabetes
    J Robinson Singleton
    Neurology, University of Utah, Salt Lake City, UT 84132, USA
    Nat Clin Pract Neurol 2:276-82. 2006
    ..Increasing epidemiological evidence also implicates the prediabetic state of impaired glucose tolerance (IGT) as a risk factor for cerebrovascular events and peripheral neuropathy...
  25. ncbi Inflammation in the prediabetic state is related to increased insulin resistance rather than decreased insulin secretion
    Andreas Festa
    Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Tex 78229 3900, USA
    Circulation 108:1822-30. 2003
    ..Previously, atherogenic changes in traditional CV risk factors in the prediabetic state were mainly seen in insulin-resistant subjects rather than in those with a predominant defect in insulin ..
  26. ncbi Plasma free Fatty Acid uptake and oxidation are already diminished in subjects at high risk for developing type 2 diabetes
    M Mensink
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht, The Netherlands
    Diabetes 50:2548-54. 2001
    ....
  27. ncbi Neuropathy in prediabetes: does the clock start ticking early?
    Nikolaos Papanas
    Heinrich Heine University, Leibniz, Germany
    Nat Rev Endocrinol 7:682-90. 2011
    ..This Review summarizes the current evidence on the association between prediabetes and neuropathy...
  28. ncbi B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes
    B Salomon
    Committee on Immunology, Ben May Institute for Cancer Research and Department of Pathology, University of Chicago, Illinois 60637, USA
    Immunity 12:431-40. 2000
    ..The results suggest that the CD28/ B7 costimulatory pathway is essential for the development and homeostasis of regulatory T cells that control spontaneous autoimmune diseases...
  29. pmc Effect of pre-diabetes on future risk of stroke: meta-analysis
    Meng Lee
    Chang Gung University College of Medicine, Chang Gung Memorial Hospital, Chiayi, Taiwan
    BMJ 344:e3564. 2012
    ..To assess the association between pre-diabetes and risk of stroke, and to evaluate whether this relation varies by diagnostic criteria for pre-diabetes...
  30. pmc Curcumin extract for prevention of type 2 diabetes
    Somlak Chuengsamarn
    Division of Endocrinology and Metabolism, Faculty of Medicine, HRH Princess Maha Chakri Sirindhorn Medical Center, Srinakharinwirot University, Nakornnayok, Thailand
    Diabetes Care 35:2121-7. 2012
    ..To assess the efficacy of curcumin in delaying development of type 2 diabetes mellitus (T2DM) in the prediabetic population...
  31. ncbi Diabetes risk reduction behaviors among U.S. adults with prediabetes
    Linda S Geiss
    CDC, Atlanta, Georgia, USA
    Am J Prev Med 38:403-9. 2010
    ..However, the extent to which U.S. adults with prediabetes are making lifestyle changes consistent with reducing risk is unknown...
  32. pmc Prevalence and correlates of diabetes in South asian indians in the United States: findings from the metabolic syndrome and atherosclerosis in South asians living in america study and the multi-ethnic study of atherosclerosis
    A M Kanaya
    Division of General Internal Medicine, University of California, San Francisco, San Francisco, California 94115, USA
    Metab Syndr Relat Disord 8:157-64. 2010
    ..Individuals from South Asia have high diabetes prevalence despite low body weight. We compared the prevalence of diabetes among South Asian Indians with other U.S. ethnic groups and explored correlates of diabetes...
  33. pmc A1C between 5.7 and 6.4% as a marker for identifying pre-diabetes, insulin sensitivity and secretion, and cardiovascular risk factors: the Insulin Resistance Atherosclerosis Study (IRAS)
    Carlos Lorenzo
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA
    Diabetes Care 33:2104-9. 2010
    ..A1C is an optional method for diagnosing diabetes and also for detecting individuals at increased risk of the disease. However, how A1C compares with fasting (FPG) and 2-h plasma glucose for detecting at-risk individuals is not well known...
  34. pmc Prediabetes and prehypertension in healthy adults are associated with low vitamin D levels
    Alok K Gupta
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA
    Diabetes Care 34:658-60. 2011
    ..To determine whether modest elevations of fasting serum glucose (FSG) and resting blood pressure (BP) in healthy adults are associated with differential serum vitamin D concentrations...
  35. pmc Serum 25-hydroxyvitamin d levels and prediabetes among subjects free of diabetes
    Anoop Shankar
    Department of Community Medicine, West Virginia University School of Medicine, Morgantown, West Virginia, USA
    Diabetes Care 34:1114-9. 2011
    ..However, previous studies have not examined the association between low serum 25(OH)D levels and prediabetes...
  36. pmc Targeting CD22 reprograms B-cells and reverses autoimmune diabetes
    Paolo Fiorina
    Transplantation Research Center, Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 57:3013-24. 2008
    ..To investigate a B-cell-depleting strategy to reverse diabetes in naïve NOD mice...
  37. ncbi Antisense oligonucleotides down-regulating costimulation confer diabetes-preventive properties to nonobese diabetic mouse dendritic cells
    Jennifer Machen
    Diabetes Institute, Department of Pediatrics, University of Pittsburgh School of Medicine, PA 15213, USA
    J Immunol 173:4331-41. 2004
    ..This approach is a useful tool by which DC-mediated activation of regulatory T cells can be studied as well as a potential therapeutic option for type 1 diabetes...
  38. ncbi Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study
    Arne Astrup
    Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark
    Lancet 374:1606-16. 2009
    ..We assessed the effect of liraglutide on bodyweight and tolerability in obese individuals without type 2 diabetes...
  39. ncbi Pathophysiology of prediabetes
    Ele Ferrannini
    Department of Internal Medicine, University of Pisa School of Medicine, Via Roma, 67, 56100 Pisa, Italy
    Med Clin North Am 95:327-39, vii-viii. 2011
    ..Although genetic influences affect β-cell function, becoming overweight is the main acquired challenge to insulin action. The phenotype of prediabetes includes dyslipidemia and higher arterial blood pressure...
  40. pmc From pre-diabetes to type 2 diabetes in obese youth: pathophysiological characteristics along the spectrum of glucose dysregulation
    Fida Bacha
    Division of Weight Management and Wellness, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Diabetes Care 33:2225-31. 2010
    ..We investigated differences in insulin sensitivity and secretion among youth with IFG, IGT, and coexistent IFG/IGT compared with those with normal glucose tolerance (NGT) and type 2 diabetes...
  41. pmc Screening adults for pre-diabetes and diabetes may be cost-saving
    Ranee Chatterjee
    Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
    Diabetes Care 33:1484-90. 2010
    ..Early detection would allow management to prevent or delay development of diabetes and diabetes-related complications. We investigated the economic justification for screening for pre-diabetes/diabetes...
  42. ncbi Coexisting prehypertension and prediabetes in healthy adults: a pathway for accelerated cardiovascular events
    Alok K Gupta
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Hypertens Res 34:456-61. 2011
    ..High prevalence of Co-PreHTN+PreDM in healthy US adults, a strong correlate for dysregulated cardiometabolic risk factors, highlights a plausible accelerated pathway for early cardiovascular events...
  43. ncbi Sensitivity and specificity of glycated hemoglobin as a diagnostic test for diabetes and prediabetes in Arabs
    Nicole R Pinelli
    Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan 48201 2417, USA
    J Clin Endocrinol Metab 96:E1680-3. 2011
    ..The diagnostic utility of A1C has not been evaluated in Arabs, a population at increased risk for developing diabetes...
  44. ncbi Quantifying the duration of pre-diabetes
    Melanie Y Bertram
    Centre for Burden of Disease and Cost Effectiveness, School of Population Health, Edith Cavell Building, Herston Rd, Herston QLD 4006
    Aust N Z J Public Health 34:311-4. 2010
    ..This study aims to calculate the duration of pre-diabetes, in order to provide supporting evidence for a screening program...
  45. ncbi Ectopic fat storage in the pancreas, liver, and abdominal fat depots: impact on β-cell function in individuals with impaired glucose metabolism
    N J van der Zijl
    Diabetes Center Department of Internal Medicine, Vrije Universiteit University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    J Clin Endocrinol Metab 96:459-67. 2011
    ..Pancreatic fat content (PFC) may have deleterious effects on β-cell function...
  46. ncbi Cinnamon intake lowers fasting blood glucose: meta-analysis
    Paul A Davis
    Department of Nutrition, University of California Davis, Davis, California 95616, USA
    J Med Food 14:884-9. 2011
    ..49±0.2 mmol/L; n=8, P=.025) and intake of cinnamon extract only also lowered FBG (-0.48 mmol/L±0.17; n=5, P=.008). Thus cinnamon extract and/or cinnamon improves FBG in people with type 2 diabetes or prediabetes...
  47. pmc Distinguishing persistent insulin autoantibodies with differential risk: nonradioactive bivalent proinsulin/insulin autoantibody assay
    Liping Yu
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes 61:179-86. 2012
    ..We hypothesize that factors related to the mechanism of loss of tolerance leading to diabetes determine high affinity and MSD-IAA reactivity...
  48. ncbi Impaired insulin sensitivity is accompanied by disturbances in skeletal muscle fatty acid handling in subjects with impaired glucose metabolism
    C C M Moors
    Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands
    Int J Obes (Lond) 36:709-17. 2012
    ....
  49. ncbi Neuropathic pain in diabetes, prediabetes and normal glucose tolerance: the MONICA/KORA Augsburg Surveys S2 and S3
    Dan Ziegler
    Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute at the Heinrich Heine University, Dusseldorf, Germany
    Pain Med 10:393-400. 2009
    ..The aim of this study was to determine the prevalence and risk factors of neuropathic pain in subjects with diabetes, impaired fasting glucose (IFG), impaired glucose tolerance (IGT), or normal glucose tolerance (NGT)...
  50. ncbi Factors determining normalization of glucose intolerance in middle-aged Swedish men and women: a 8-10-year follow-up
    M Alvarsson
    Endocrine and Diabetes Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Diabet Med 26:345-53. 2009
    ..To examine factors in middle-aged Swedish men and women predicting the conversion from a state of abnormal glucose regulation to normal glucose tolerance (NGT) after 8-10 years...
  51. pmc The prevention of type 2 diabetes
    JILL P CRANDALL
    Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Nat Clin Pract Endocrinol Metab 4:382-93. 2008
    ..Widespread application has, however, been limited by local financial considerations, even though cost-effectiveness might be achieved at the population level...
  52. pmc Prevalence and trends of the diabetes epidemic in South Asia: a systematic review and meta-analysis
    Ranil Jayawardena
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia
    BMC Public Health 12:380. 2012
    ..We discuss the prevalence of pre-diabetes and diabetes in South Asia and explore the differential risk factors reported...
  53. pmc Defects in oxygen supply to skeletal muscle of prediabetic ZDF rats
    Christopher G Ellis
    Dept of Medical Biophysics, Univ of Western Ontario, London, ON, N6A 5C1, Canada
    Am J Physiol Heart Circ Physiol 298:H1661-70. 2010
    ....
  54. ncbi Dietary treatment with rice containing resistant starch improves markers of endothelial function with reduction of postprandial blood glucose and oxidative stress in patients with prediabetes or newly diagnosed type 2 diabetes
    Jung Hyun Kwak
    Yonsei University Research Institute of Science for Aging, Yonsei University, Seoul, Republic of Korea
    Atherosclerosis 224:457-64. 2012
    ..We aimed to evaluate whether 4-week of dietary treatment with rice containing resistant starch reduces blood glucose and oxidative stress as well as improves endothelial function...
  55. ncbi Isolated impaired fasting glucose and peripheral insulin sensitivity: not a simple relationship
    Sun H Kim
    Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
    Diabetes Care 31:347-52. 2008
    ..To subject this conclusion to further validation, we evaluated the relationship between glucose tolerance categories and peripheral insulin sensitivity in a large nondiabetic population...
  56. ncbi The potential impact and optimal cut-points of using glycated haemoglobin, HbA1c, to detect people with impaired glucose regulation in a UK multi-ethnic cohort
    Samiul A Mostafa
    Division of Diabetes and Endocrinology, Department of Cardiovascular Sciences, Leicester Royal Infirmary, Leicester, UK
    Diabetes Res Clin Pract 90:100-8. 2010
    ..We investigated the impact on prevalence/phenotype from using these criteria compared to IGR detected on oral glucose tolerance testing (OGTT) and determined optimal HbA1c cut-points for IGR in a multi-ethnic cohort...
  57. ncbi Assessment and treatment of cardiovascular risk in prediabetes: impaired glucose tolerance and impaired fasting glucose
    Ralph A DeFronzo
    Diabetes Division, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    Am J Cardiol 108:3B-24B. 2011
    ..The treatment of these CV risk factors should follow the same guidelines established for patients with type 2 diabetes, and should be aggressively followed to reduce future CV events...
  58. pmc Age- and islet autoimmunity-associated differences in amino acid and lipid metabolites in children at risk for type 1 diabetes
    Maren Pflueger
    Forschergruppe Diabetes eV at Helmholtz Center Munich, Neuherberg, Germany
    Diabetes 60:2740-7. 2011
    ..To support this notion, we examined whether serum metabolite profiles differ between children with respect to islet autoantibody status and the age of islet autoantibody development...
  59. ncbi Serum lipid and hsCRP levels in prediabetes--impaired fasting glucose (IFG) and impaired glucose tolerance (IGT)
    Nevena Chakarova
    Department of Diabetology, Clinical Center of Endocrinology, University Hospital of Endocrinology, Medical University, Sofia, Bulgaria
    Diabetes Res Clin Pract 86:56-60. 2009
    ..To evaluate cardiovascular risk in prediabetes (IFG and IGT) assessed by serum lipid and hsCRP levels...
  60. pmc Diabetes and its chronic complications in the She ethnic minority group of China
    Yinghua Lin
    Department of Endocrinology, Ningde Municipal Hospital, Fujian Medical University, Ningde, China
    Diabetes Technol Ther 14:430-9. 2012
    ..The present study investigated the prevalence of type 2 diabetes and associated risk factors in the adult population of She nationals...
  61. ncbi Pre-diabetes essential action: a European perspective
    P Valensi
    Department of Endocrinology Diabetology Nutrition, Jean Verdier Hospital, Avenue du 14 Juillet, F 93140 Bondy, France
    Diabetes Metab 31:606-20. 2005
  62. ncbi Pre-treatment with a DPP-4 inhibitor is infarct sparing in hearts from obese, pre-diabetic rats
    Barbara Huisamen
    MRC Cape Heart Centre, Cape Town, Republic of South Africa
    Cardiovasc Drugs Ther 25:13-20. 2011
    ..We conclude that treatment with PFK275-055 for 4 weeks protected the heart against ischaemia/reperfusion injury, elevated GLP-1 levels and improved metabolic control in obese, pre-diabetic rats...
  63. pmc Location of arterial stiffening differs in those with impaired fasting glucose versus diabetes: implications for left ventricular hypertrophy from the Multi-Ethnic Study of Atherosclerosis
    Pairoj Rerkpattanapipat
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Diabetes 58:946-53. 2009
    ....
  64. ncbi Prevalence of diagnosed and undiagnosed diabetes mellitus and its risk factors in a population-based study of Qatar
    Abdulbari Bener
    Dept of Medical Statistics and Epidemiology, Hamad Medical Corporation, Qatar
    Diabetes Res Clin Pract 84:99-106. 2009
    ..The objective of the study was to determine the prevalence of diagnosed and undiagnosed diabetes, pre-diabetes and to identify the associated risk factors in the sample of adult Qatari population...
  65. pmc Effects of exenatide and lifestyle modification on body weight and glucose tolerance in obese subjects with and without pre-diabetes
    Julio Rosenstock
    Dallas Diabetes and Endocrine Center at Medical City, Dallas, Texas, USA
    Diabetes Care 33:1173-5. 2010
    ..To assess the effects of exenatide on body weight and glucose tolerance in nondiabetic obese subjects with normal or impaired glucose tolerance (IGT) or impaired fasting glucose (IFG)...
  66. pmc Incidence rates and predictors of diabetes in those with prediabetes: the Strong Heart Study
    Hong Wang
    MedStar Health Research Institute, Hyattsville, MD, USA
    Diabetes Metab Res Rev 26:378-85. 2010
    ..In this article, diabetes risk factors and incidence rates in American Indians (AI) with prediabetes are examined...
  67. ncbi Degeneration of the Golgi and neuronal loss in dorsal root ganglia in diabetic BioBreeding/Worcester rats
    H Kamiya
    Department of Pathology, Wayne State University, School of Medicine, Scott Hall 9275, 540 E Canfield Avenue, Detroit, MI 48201, USA
    Diabetologia 49:2763-74. 2006
    ..The aim of this study was to evaluate the nature and extent of neuronal loss in dorsal root ganglia (DRG) in diabetic polyneuropathy...
  68. pmc Prediabetes is not all about obesity: association between plasma leptin and prediabetes in lean rural Chinese adults
    Guoying Wang
    Department of Pediatrics, Northwestern University Feinberg School of Medicine and Children s Memorial Hospital, Chicago, Illinois 60614, USA
    Eur J Endocrinol 163:243-9. 2010
    ..This study investigated the associations of plasma leptin levels with insulin resistance (IR) and prediabetes in relatively lean, rural Chinese men and women...
  69. pmc Tissue-targeted therapy of autoimmune diabetes using dendritic cells transduced to express IL-4 in NOD mice
    Remi J Creusot
    Department of Medicine, Division of Immunology and Rheumatology, Stanford, CA 94305 5166, USA
    Clin Immunol 127:176-87. 2008
    ....
  70. ncbi Identifying individuals at high risk for diabetes: The Atherosclerosis Risk in Communities study
    Maria Ines Schmidt
    Graduate Studies Program in Epidemiology, School of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
    Diabetes Care 28:2013-8. 2005
    ..To develop and evaluate clinical rules to predict risk for diabetes in middle-aged adults...
  71. ncbi Ten-year risk of cardiovascular incidence related to diabetes, prediabetes, and the metabolic syndrome
    Jing Liu
    Capital Medical University attached Beijing Anzhen Hospital, Beijing, China
    Am Heart J 153:552-8. 2007
    ..We aimed to compare MetS with dysglycemia in their association with the 10-year incidence risk of CVD...
  72. pmc Screening for diabetes and pre-diabetes with proposed A1C-based diagnostic criteria
    Darin E Olson
    Atlanta VA Medical Center, Decatur, Georgia, USA
    Diabetes Care 33:2184-9. 2010
    ..We hypothesized that screening for diabetes and pre-diabetes with A1C measurements would differ from using oral glucose tolerance tests (OGTT)...
  73. ncbi Screening for type 2 diabetes
    M M Engelgau
    Division of Diabetes Translation, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Diabetes Care 23:1563-80. 2000
    ..Finally, combinations of screening tests and different screening intervals should be evaluated within economic studies to allow selection of the optimal approach within the financial and resource limitations of the health care system...
  74. pmc Activating transcription factor 6 (ATF6) sequence polymorphisms in type 2 diabetes and pre-diabetic traits
    Winston S Chu
    Division of Endocrinology 111J 1 LR, Department of Medicine, University of Arkansas for Medical Sciences, John L McClellan Memorial Veterans Hospital, 4700 W 7th Street, Little Rock, AR 72205, USA
    Diabetes 56:856-62. 2007
    ..ATF6 does not appear to play a major role in type 2 diabetes, but further work is required to identify the cause of the allelic expression imbalance...
  75. ncbi Efficient cutoff points for three screening tests for detecting undiagnosed diabetes and pre-diabetes: an economic analysis
    Ping Zhang
    Division of Diabetes Translation, Centers for Disease Control and Prevention, Mailstop K 10, 4770 Buford Highway NE, Atlanta, GA 30341, USA
    Diabetes Care 28:1321-5. 2005
    ..The aim of this study was to determine efficient cutoff points for three screening tests for detecting undiagnosed diabetes alone or both undiagnosed diabetes and pre-diabetes...
  76. ncbi Can the onset of type 2 diabetes be delayed by a group-based lifestyle intervention? A randomised control trial
    Susan M Moore
    Faculty of Life and Social Sciences, Swinburne University of Technology, Melbourne, Australia
    Psychol Health 26:485-99. 2011
    ..The intervention group also changed their diagnostic status from pre-diabetes to non-diabetes at a greater rate than the wait group (43% vs. 26%) who received standard care from their GPs...
  77. pmc Implications of alternative definitions of prediabetes for prevalence in U.S. adults
    Cherie James
    RTI International, Atlanta Regional Office, Atlanta, Georgia, USA
    Diabetes Care 34:387-91. 2011
    ..To compare the prevalence of prediabetes using A1C, fasting plasma glucose (FPG), and oral glucose tolerance test (OGTT) criteria, and to examine the degree of agreement between the measures...
  78. ncbi Diagnosis and management of type 2 diabetes in adults: a review of the ICSI guideline
    Shai Gavi
    State University of New York SUNY Stony Brook School of Medicine, Stony Brook, NY, USA
    Geriatrics 64:12-7, 29. 2009
    ..Management strategies from the evidence-based guideline will include recommendations for nutrition therapy, physical activity, self-management approaches, and pharmacologic agents...
  79. pmc Altered intramuscular lipid metabolism relates to diminished insulin action in men, but not women, in progression to diabetes
    Leigh Perreault
    Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado Denver School of Medicine, Aurora, Colorado, USA
    Obesity (Silver Spring) 18:2093-100. 2010
    ..4 µg/mg dry weight, P = 0.03) and FSR being lower (0.23 ± 0.04 vs. 0.42 ± 0.06 %/h, P = 0.02) in women. Alterations in IMTG metabolism relate to diminished insulin action in men, but not women, in the progression toward diabetes...
  80. ncbi Prediabetes: the importance of early identification and intervention
    Willa A Hsueh
    Diabetes Research Center, The Methodist Hospital Research Institute, Weill Cornell Medical College, Houston, TX 77030, USA
    Postgrad Med 122:129-43. 2010
    ..This review discusses the pathophysiology of prediabetes and its clinical implications, highlighting the importance of early identification and intervention...
  81. pmc Trends of earlier and later responses of C-peptide to oral glucose challenges with progression to type 1 diabetes in diabetes prevention trial-type 1 participants
    Jay M Sosenko
    Division of Endocrinology, University of Miami, Miami, Florida, USA
    Diabetes Care 33:620-5. 2010
    ..001); peak C-peptide levels were less predictive (P < 0.05). CONCLUSIONS A decreased early C-peptide response to oral glucose and an increased later response occur at least 2 years before the diagnosis of type 1 diabetes...
  82. ncbi Epidemiology of prediabetes
    Stephen Colagiuri
    Boden Institute of Obesity, Nutrition and Exercise, University of Sydney, K25 Medical Foundation Building, New South Wales 2006, Australia
    Med Clin North Am 95:299-307, vii. 2011
    ..Increasingly, multifactorial risk tools are being used and cut-points set to identify approximately 15% of the population as being at high risk...
  83. pmc Utility of hemoglobin A(1c) for diagnosing prediabetes and diabetes in obese children and adolescents
    Paulina Nowicka
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA
    Diabetes Care 34:1306-11. 2011
    ..This recommendation is based on data in adults showing the relationship between A1C with future development of diabetes and microvascular complications. However, studies in the pediatric population are lacking...
  84. ncbi Pathophysiology of prediabetes
    Muhammad A Abdul-Ghani
    Diabetes Division, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Curr Diab Rep 9:193-9. 2009
    ..In this article, we summarize the metabolic abnormalities that characterize each state and the contribution of these metabolic abnormalities to the increased risk of diabetes and cardiovascular disease...
  85. ncbi Prediabetes and blood pressure effects on heart rate variability, QT-interval duration, and left ventricular hypertrophy in overweight-obese adolescents
    Shirleatha Lee
    The University of Memphis, Memphis, TN, USA
    J Pediatr Nurs 26:416-27. 2011
    ..319), BP (p = .286), or the interaction between glucose regulation and BP (p = .132). The additive effect of prediabetes and elevated BP did not impact cardiac autonomic function in overweight-obese youth...
  86. pmc Decreased NO signaling leads to enhanced vasoconstrictor responsiveness in skeletal muscle arterioles of the ZDF rat prior to overt diabetes and hypertension
    Lisa A Lesniewski
    Dept of Health and Kinesiology, Texas A and M University, College Station, Texas, USA
    Am J Physiol Heart Circ Physiol 294:H1840-50. 2008
    ..Collectively, these results indicate that increases in vasoconstrictor responsiveness resulting from diminished NO signaling in skeletal muscle arterioles precede the development of diabetes and hypertension in ZDF rats...
  87. ncbi Diabetes, impaired fasting glucose, and development of cognitive impairment in older women
    K Yaffe
    Department of Psychiatry, University of California, San Francisco, Box 181 4150 Clement St, San Francisco, CA 94121, USA
    Neurology 63:658-63. 2004
    ..To investigate the association between diabetes and impaired fasting glucose (IFG) and cognition and risk of developing both dementia and mild cognitive impairment (MCI) in older women...
  88. ncbi Prevalence and risk factors of diabetes in a community-based study in North India: the Chandigarh Urban Diabetes Study (CUDS)
    P Ravikumar
    Department of Endocrinology and School of Public Health, Postgraduate Institute of Medical Education and Research, 160012 Chandigarh, India
    Diabetes Metab 37:216-21. 2011
    ..As there have been few studies in North India of the prevalence of diabetes within the past decade, this study aimed to assess the prevalence and risk factors associated with diabetes in the North Indian city of Chandigarh...
  89. pmc Population-based study on the prevalence and risk factors of orthostatic hypotension in subjects with pre-diabetes and diabetes
    Jin Shang Wu
    Department of Family Medicine, College of Medicine, National Cheng Kung University, Taiwan, Republic of China
    Diabetes Care 32:69-74. 2009
    ....
  90. ncbi Effects of Aloe vera supplementation in subjects with prediabetes/metabolic syndrome
    Sridevi Devaraj
    Department of Pathology and Immunology, Baylor College of Medicine, and Texas Children s Hospital, Houston, Texas, USA
    Metab Syndr Relat Disord 11:35-40. 2013
    ..Thus, the objective of this pilot study was to examine the effect of aloe compared to placebo on fasting blood glucose, lipid profile, and oxidative stress in subjects with prediabetes/metabolic syndrome...
  91. ncbi A novel peroxisome proliferator--activated receptor alpha/gamma dual agonist ameliorates dyslipidemia and insulin resistance in prediabetic rhesus monkeys
    Shi Ying Ding
    Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Metabolism 56:1334-9. 2007
    ..The positive effects of TAK-559 in nonhuman primates have led to further clinical trials of TAK-559 in Europe and the United States...
  92. pmc Prevention of type 2 diabetes: risk status, clinic, and community
    K M Venkat Narayan
    Hubert Department of Global Health, The Rollins School of Public Health, Emory University, 1518 Clifton Rd, Atlanta, GA 30322, USA
    J Gen Intern Med 25:154-7. 2010
    ....
  93. ncbi The relationship between endothelial dysfunction and oxidative stress in diabetes and prediabetes
    Y Su
    Department of Endocrinology, First Affiliated Hospital of Harbin Medical University, Harbin, China
    Int J Clin Pract 62:877-82. 2008
    ..The aim of the present study was to determine whether increased OS and impaired endothelial function, are present in early states of diabetes, such as impaired glucose tolerance (IGT) and impaired fasting glucose (IFG)...
  94. pmc Changes in risk variables of metabolic syndrome since childhood in pre-diabetic and type 2 diabetic subjects: the Bogalusa Heart Study
    Quoc Manh Nguyen
    Tulane Center for Cardiovascular Health, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
    Diabetes Care 31:2044-9. 2008
    ..However, information is lacking regarding the long-term and adverse changes of metabolic syndrome variables in the development of type 2 diabetes from childhood to adulthood...
  95. pmc Prediabetes in obese youth: a syndrome of impaired glucose tolerance, severe insulin resistance, and altered myocellular and abdominal fat partitioning
    Ram Weiss
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    Lancet 362:951-7. 2003
    ..is common among obese adolescents, but the changes in insulin sensitivity and secretion that lead to this prediabetic state are unknown...
  96. pmc Natural history of insulin sensitivity and insulin secretion in the progression from normal glucose tolerance to impaired fasting glycemia and impaired glucose tolerance: the Inter99 study
    Kristine Faerch
    Steno Diabetes Center, Gentofte, Denmark
    Diabetes Care 32:439-44. 2009
    ..The aim of this study was to describe the natural history of insulin secretion and insulin sensitivity in the development of isolated impaired fasting glycemia (i-IFG), isolated impaired glucose tolerance (i-IGT), and combined IFG/IGT...
  97. ncbi Cost-effectiveness of screening for pre-diabetes among overweight and obese U.S. adults
    Thomas J Hoerger
    Center of Excellence in Health Promotion Economics, RTI International, 3040 Cornwallis Rd, P O Box 12194, Research Triangle Park, NC 27709, USA
    Diabetes Care 30:2874-9. 2007
    ..To estimate the cost-effectiveness of screening overweight and obese individuals for pre-diabetes and then modifying their lifestyle based on the Diabetes Prevention Program (DPP)...
  98. pmc Impaired fasting glucose with or without impaired glucose tolerance: progressive or parallel states of prediabetes?
    Leigh Perreault
    Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Am J Physiol Endocrinol Metab 295:E428-35. 2008
    ..Together, these data indicate that IFG/IGT may be a distinct prediabetic syndrome rather than progression from IFG...
  99. ncbi Diabetes Risk Calculator: a simple tool for detecting undiagnosed diabetes and pre-diabetes
    Kenneth E Heikes
    Archimedes, San Francisco, California, USA
    Diabetes Care 31:1040-5. 2008
    ..The objective of this study was to develop a simple tool for the U.S. population to calculate the probability that an individual has either undiagnosed diabetes or pre-diabetes...
  100. ncbi Accelerated endothelial dysfunction in mild prediabetic insulin resistance: the early role of reactive oxygen species
    Edward R Duncan
    The Cardiovascular Division, King s College London School of Medicine, King s College London, London, UK
    Am J Physiol Endocrinol Metab 293:E1311-9. 2007
    ....
  101. ncbi Impact of impaired fasting glucose on cardiovascular disease: the Framingham Heart Study
    Yamini S Levitzky
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts 01702 5827, USA
    J Am Coll Cardiol 51:264-70. 2008
    ..We sought to determine whether impaired fasting glucose (IFG) predicts cardiovascular disease (CVD) events...

Research Grants63

  1. Effective treatment of sleep apnea in prediabetes to reduce cardiometabolic risk
    Esra Tasali; Fiscal Year: 2010
    ..b>Prediabetic state is a major risk factor for cardiovascular disease and progression to overt diabetes...
  2. A Novel Approach Applying CGM Metrics to Identify a Prediabetic State
    MASSIMO T PIETROPAOLO; Fiscal Year: 2013
    ....
  3. Pathobiology and Reversibility of Prediabetes in a Biracial Cohort
    Samuel Dagogo-Jack; Fiscal Year: 2013
    ..among African-Americans and Caucasians offspring of parents with type 2 diabetes;and 4) Duration of the prediabetic state is a major determinant of, and is inversely related to, the efficacy of lifestyle intervention to induce ..
  4. DIABETES MELLITUS & ISLET AMYLOID POLYPEPTIDE (IAAP)
    Kenneth Johnson; Fiscal Year: 1991
    ..Amyloid samples will be purified by size exclusion and revered phase HPLC for subsequent amino acid sequencing...
  5. CONTROL MECHANISMS OF HEPATIC GLUCOSE OUTPUT
    John Clore; Fiscal Year: 2000
    ..are easily demonstrated in patients with hyperglycemia, but increased HGO is not generally seen in the prediabetic state when plasma glucose levels are minimally elevated...
  6. Obesity/Insulin Resistance and Endothelial t-PA Release
    CHRISTOPHER DESOUZA; Fiscal Year: 2003
    ..provide mechanistic insight into the excess risk of atherothrombosis observed in the obese/insulin resistant prediabetic state, and experimental support for future antioxidant supplementation trials aimed at reducing/preventing ..
  7. GENETICS OF ADIPOSITY AND GLUCOSE HOMEOSTASIS
    Carlos Lorenzo; Fiscal Year: 2008
    ....
  8. Insulin Resistance and Adenomas of the Colorectum
    Steven Haffner; Fiscal Year: 2003
    ..abstract_text> ..
  9. Gene Expression in Prediabetes: Potential Role of PGC-1
    MARY PATTI; Fiscal Year: 2006
    ..abstract_text> ..
  10. Alcohol Intake on Insulin Sensitivity and Heart Disease
    Sun Kim; Fiscal Year: 2006
    ..Given the morbidity and mortality of insulin resistance and CVD, it becomes important to clarify the role of moderate alcohol consumption to both. ..
  11. Obesity, Oxidative Stress, and Diabetes in Older Adults
    Alka Kanaya; Fiscal Year: 2007
    ..If these markers are implicated in causing diabetes, then this would lead to testing whether vitamins or other supplements that target these markers may decrease the risk of diabetes in obese individuals. [unreadable] [unreadable]..
  12. Periodontitis, Atherosclerosis and the Host Response
    Evanthia Lalla; Fiscal Year: 2007
    ..We propose to employ this model to dissect the factors accelerating vascular inflammation and atherosclerosis in periodontitis. ..
  13. Periodontal microbiota, serum Antibody response & T1DM
    Evanthia Lalla; Fiscal Year: 2002
    ..Theses studies will markedly enhance our understanding of the oral microbiology and immunology in type 1 diabetes. ..
  14. Metabolic Syndrome and Atherosclerosis in South Asians
    Alka Kanaya; Fiscal Year: 2008
    ..End of Abstract) [unreadable] [unreadable]..
  15. Biomarkers and Outcomes in the Diabetes Prevention Program
    Ronald B Goldberg; Fiscal Year: 2010
    ....
  16. Phenotype-Genotype Interactions and Type 2 Diabetes
    James Meigs; Fiscal Year: 2005
    ..Results will provide a foundation for future laboratory efforts and will increase understanding of phenotype-genotype interactions in diabetes pathogenesis. ..
  17. Angll and PPARy/LXR in Atherosclerosis
    Willa Hsueh; Fiscal Year: 2008
    ..4) Determine whether PPARgamma ligands or LXRaalpha ligands can induce regression of established atherosclerosis. ..
  18. Mechanisms of CVD and Endothelial Dysfunction in Obesity
    Willa Hsueh; Fiscal Year: 2006
    ..Early intervention is critical if we are to prevent these two major diseases, which may, indeed, be the same disease. ..
  19. Diabetes Control in High-risk Urban African-Americans
    Mary Rhee; Fiscal Year: 2003
    ..Information from these analyses will be critical to guide development of programs aimed at eliminating the health disparity of African-Armenians with diabetes. ..
  20. PPARGAMMA AND AII IN GLOMERULOSCLEROSIS
    Willa Hsueh; Fiscal Year: 2002
    ..abstract_text> ..
  21. ANGIOTENSIN II AND MITOGEN ACTIVATED PROTEIN KINASE
    Willa Hsueh; Fiscal Year: 2003
    ..5) Investigate the mechanism of transcription at regulation of PAI-1 by hyperglycemia AngII, insulin and the MAPK inhibitor in cultured rat cardiac fibroblasts. ..
  22. IMPROVING PRIMARY CARE OF AFRICAN AMERICANS WITH NIDDM
    Lawrence Phillips; Fiscal Year: 2001
    ..Our interventions should delineate approaches effective in a primary care setting, as needed to improve care and prevent complications in urban African-Americans with NIDDM. ..
  23. Screening for IGT: Glucose Challenge vs Predictive Model
    Lawrence Phillips; Fiscal Year: 2007
    ..By applying existing knowledge to disease control and prevention, our Specific Aims are the critical first steps to solve this problem. ..
  24. Dopamine mechanisms in development of type-2 diabetes
    Andras Hajnal; Fiscal Year: 2008
    ..These studies will help determine how plasticity in the dopaminergic system affects behavioral and metabolic factors related to hyperphagia and the development of dietary-induced NIDDM. ..
  25. 2007 International Peripheral Nerve Society Meeting at Snowbird, Utah
    A Smith; Fiscal Year: 2007
    ..The meeting directly impacts public health and patient care by disseminating important new ideas (both research and therapeutic) and by developing consensus guidelines. [unreadable] [unreadable] [unreadable]..
  26. GUSTATORY REWARD AND DOPAMINE IN THE NUCLEUS ACCUMBENS
    Andras Hajnal; Fiscal Year: 2003
    ..This knowledge is directly relevant to understanding the control of normal ingestive behavior and to the maladies related to this essential behavior, such as obesity, anorexia nervosa, bulimia nervosa, and binge eating disorder. ..
  27. Insulin-Like Growth Factor Axis and Type 2 Diabetes
    Swapnil Rajpathak; Fiscal Year: 2010
    ..The IGF-axis may potentially play a role in the etiology of type 2 diabetes and its related conditions and may also provide a novel therapeutic target for its prevention. ..
  28. PATHOGENESIS OF TYPE 2 DIABETES IN LATINO WOMEN
    Thomas Buchanan; Fiscal Year: 2006
    ..The information will be important for the design of strategies to identify high-risk individuals and reduce their risk of type 2 diabetes. ..
  29. FAT MEDIATED INSULIN SECRETION AND DIABETES IN ELDERLY
    Guenther Boden; Fiscal Year: 2003
    ..We hope that this project will help to better understand the mechanisms by which obesity contributes to the development of NIDDM. ..
  30. Cancer Center Renovation Grant
    Donald Wilson; Fiscal Year: 2004
    ....
  31. Androgens and Cardiovascular Risk in African Americans
    Bonita Falkner; Fiscal Year: 2005
    ..The results of this project can contribute to the development of prevention and earlier intervention strategies, including more specific therapeutic targets, for this high-risk minority population. ..
  32. Muscle PPARgamma and Metabolic Regulation
    Andrew Norris; Fiscal Year: 2008
    ..abstract_text> ..
  33. Dissection of cellular interactions with integrated functional genomics in comple
    Martin Hessner; Fiscal Year: 2008
    ..Understanding the relationship between mast cells, T effector, and TREG cells in autoimmunity and has the potential to establish a new paradigm for immune regulation and create new insights to human disease. ..
  34. CONSTRUCTION OF RESEARCH ANIMAL FACILITY
    Donald Wilson; Fiscal Year: 2002
    ..The proposed project, which will be co-financed by contributions from the State of Maryland, therefore, considered instrumental for sustaining the stature of the MPRC in schizophrenia research. ..
  35. Becton Dickinson LSR-II Analytical Cytometer (BD-LSR-II)
    David Serreze; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  36. INTRA-ABDOMINAL FAT AND RISK OF DISEASE IN ADOLESCENTS
    Michael Goran; Fiscal Year: 2008
    ....
  37. Vascular Alterations in the Prediabetic Condition
    Cynthia Cheng; Fiscal Year: 2008
    ....
  38. CALORIC RESTRICTION, AGING, AND INSULIN ACTION
    William Cefalu; Fiscal Year: 2001
    ....
  39. Individual and Environmental Mechanisms of PA Change
    Paul Estabrooks; Fiscal Year: 2008
    ..This project uniquely utilizes methods that will facilitate institutionalization of the intervention components following the successful completion of the trial and potential adoption of the intervention in other health care settings. ..
  40. ANTIGEN PRESENTING CELL DEFECTS IN AUTOIMMUNE DIABETES
    David Serreze; Fiscal Year: 2009
    ..Successful completion of our proposed studies might ultimately provide means for preventing the development of this devastating disease. ..
  41. Mechanisms of ATP Release from RBC's
    Randy Sprague; Fiscal Year: 2007
    ..abstract_text> ..
  42. Conflict of Interest in Clinical Practice Guideline Development
    Susan L Norris; Fiscal Year: 2010
    ..Understanding the impact of industry relationships will help guideline sponsors to develop appropriate policies for managing conflict of interest. ..
  43. DQB1*0602 RELATIVES--MECHANISMS FOR DIABETES PROTECTION
    Carla Greenbaum; Fiscal Year: 2001
    ..This proposal includes collaborative agreements between the University of Washington and the Universities of Florida (Gainesville), South Florida (Tampa), and Colorado. ..
  44. Diet and Exercise in Type 2 Diabetes
    Kerry J Stewart; Fiscal Year: 2010
    ....
  45. IMMUNOTHERAPY TRIAL IN NEW ONSET TYPE 1 DIABETES
    Peter Gottlieb; Fiscal Year: 2002
    ..The safety of these agents in clinical use justifies a trial in type I diabetes, where 30 percent of new onset subjects run HbAlc levels that put them at high risk for vascular disease within 20 years. ..
  46. HORMONE REPLACEMENT FOR PREVENTION OF VISCERAL OBESITY
    William Cefalu; Fiscal Year: 2002
    ....
  47. Evaluation of MicroRNA Expression in CD4 T cells in Type 1 Diabetes
    Alberto Pugliese; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  48. ISLET FUNCTION IN TYPE 2 DIABETES
    Steven Kahn; Fiscal Year: 2003
    ..The applicant has successfully trained a number of young investigators in the areas of patient-oriented and basic research and a plan to continue doing so is presented. ..
  49. GENERAL CLINICAL RESEARCH CENTER
    AUBREY MD HOUGH; Fiscal Year: 2006
    ..In this second funding cycle, the UAMS GCRC will continue expanding campus-wide clinical investigation. Support from all three sister institutions will continue to ensure GCRC success. ..
  50. EXTRAMURAL RESEARCH FACILITIES IMPROVEMENT PROVEMENT
    Donald Wilson; Fiscal Year: 2003
    ....
  51. Poly(ADP-ribose) polymerase in diabetic nephropathy
    IRINA OBROSOVA; Fiscal Year: 2006
    ..abstract_text> ..
  52. Health Values and Treatment of Pediatric Type 2 Diabetes
    ERINN RHODES; Fiscal Year: 2006
    ..This importantresearch will assist Dr. Rhodes in advancing toward her long-term goal of improving the health and quality of life of children with and at risk of T2DM. ..
  53. NOD B Cells in Determinant Spreading of T Cell Immunity
    Jide Tian; Fiscal Year: 2004
    ..These studies will address fundamental questions concerning the role of B cells in T cell autoimmunity and may provide a basis to develop novel immunotherapies for the intervention of human IDDM. ..
  54. Mechanisms of Beta cell Compensation and Failure
    John Leahy; Fiscal Year: 2007
    ..abstract_text> ..
  55. The Environmental Epidemiology of Arrythmogenesis in WHI
    Eric Whitsel; Fiscal Year: 2007
    ..S. air quality standards, and yield insight into the relatively gradual decline of sudden cardiac death rates among U.S. women over the last decade. ..
  56. Prevention of Diabetes with Lipid Immunomodulators
    Teresa Dilorenzo; Fiscal Year: 2005
    ....
  57. CARDIOVASCULAR NUTRITION IN MEDICAL EDUCATION
    Scott Grundy; Fiscal Year: 2002
    ..The long term goal is to produce graduates who routinely address nutrition and exercise for cardiovascular health with their patients. ..
  58. TrialNet: University of Florida Clinical Center and Network
    Desmond Schatz; Fiscal Year: 2007
    ..It is thus a promising agent to consider for the prevention of Type 1 diabetes. ..
  59. Melatonin Supplementation in Hypertensive Patients
    FRANK SCHEER; Fiscal Year: 2007
    ..Furthermore, supplementation of suppressed nighttime melatonin levels may lead to a novel strategy in the treatment of essential hypertension. [unreadable]..
  60. Diabetes-specific regulatory T cells induced by DCs
    Kristin Tarbell; Fiscal Year: 2006
    ..My long-term scientific goal is to understand the control of self-tolerance such that autoimmunity can be controlled in an autoantigen-specific way [unreadable] [unreadable]..
  61. PET Imaging of the Pancreas in Murine Models of Diabetes
    Paige Clark; Fiscal Year: 2005
    ..The method could also be useful in evaluating the function of pancreatic transplants and successful engraftment of transplanted progenitor or beta cells. ..
  62. Fat Induced Insulin Resistance and Atherosclerosis
    Guenther Boden; Fiscal Year: 2007
    ..We believe that these studies will provide important new information relative to the mechanism by which obesity and FFAs cause IR and ASVD in human subjects. ..