experimental diabetes mellitus

Summary

Summary: Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY.

Top Publications

  1. ncbi Diabetic cardiomyopathy revisited
    Sihem Boudina
    Division of Endocrinology, Metabolism and Diabetes and Program in Human Molecular Biology and Genetics, University of Utah School of Medicine, Salt Lake City 84112, USA
    Circulation 115:3213-23. 2007
  2. ncbi The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas
    T Szkudelski
    Department of Animal Physiology and Biochemistry, University of Agriculture, Poznan, Poland
    Physiol Res 50:537-46. 2001
  3. ncbi Vascular damage in a mouse model of diabetic retinopathy: relation to neuronal and glial changes
    Rachel A Feit-Leichman
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 46:4281-7. 2005
  4. ncbi Diabetic endothelial nitric oxide synthase knockout mice develop advanced diabetic nephropathy
    Takahiko Nakagawa
    Division of Nephrology, Hypertension and Transplantation, University of Florida, PO Box 100224, Gainesville, FL 32610 0224, USA
    J Am Soc Nephrol 18:539-50. 2007
  5. pmc Resveratrol alleviates cardiac dysfunction in streptozotocin-induced diabetes: Role of nitric oxide, thioredoxin, and heme oxygenase
    Mahesh Thirunavukkarasu
    Department of Surgery, Molecular Cardiology and Angiogenesis Laboratory, University of Connecticut Medical Center, 263 Farmington Avenue, Farmington, CT 06030 1110, USA
    Free Radic Biol Med 43:720-9. 2007
  6. ncbi Mechanisms underlying endothelial dysfunction in diabetes mellitus
    U Hink
    Universitatskrankenhaus Eppendorf, Germany
    Circ Res 88:E14-22. 2001
  7. ncbi Suppression of accelerated diabetic atherosclerosis by the soluble receptor for advanced glycation endproducts
    L Park
    Department of Surgery, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Nat Med 4:1025-31. 1998
  8. ncbi Abnormalities of retinal metabolism in diabetes and experimental galactosemia. VII. Effect of long-term administration of antioxidants on the development of retinopathy
    R A Kowluru
    Kresge Eye Institute, Wayne State University, Detroit, Michigan 48201, USA
    Diabetes 50:1938-42. 2001
  9. ncbi Increased renal expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 in experimental diabetes
    M E Cooper
    Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, West Heidelberg, Victoria, Australia
    Diabetes 48:2229-39. 1999
  10. ncbi Attenuation by metallothionein of early cardiac cell death via suppression of mitochondrial oxidative stress results in a prevention of diabetic cardiomyopathy
    Lu Cai
    Department of Medicine, The University of Louisville, Louisville, Kentucky, USA
    J Am Coll Cardiol 48:1688-97. 2006

Detail Information

Publications277 found, 100 shown here

  1. ncbi Diabetic cardiomyopathy revisited
    Sihem Boudina
    Division of Endocrinology, Metabolism and Diabetes and Program in Human Molecular Biology and Genetics, University of Utah School of Medicine, Salt Lake City 84112, USA
    Circulation 115:3213-23. 2007
    ..This review discusses the latest findings in diabetic humans and in animal models and reviews emerging new mechanisms that may be involved in the development and progression of cardiac dysfunction in diabetes...
  2. ncbi The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas
    T Szkudelski
    Department of Animal Physiology and Biochemistry, University of Agriculture, Poznan, Poland
    Physiol Res 50:537-46. 2001
    ..Furthermore, streptozotocin liberates toxic amounts of nitric oxide that inhibits aconitase activity and participates in DNA damage. As a result of the streptozotocin action, B cells undergo the destruction by necrosis...
  3. ncbi Vascular damage in a mouse model of diabetic retinopathy: relation to neuronal and glial changes
    Rachel A Feit-Leichman
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 46:4281-7. 2005
    ..The objective of this study was to characterize the occurrence and pathologic progression of diabetic retinopathy in C57Bl/6J mice...
  4. ncbi Diabetic endothelial nitric oxide synthase knockout mice develop advanced diabetic nephropathy
    Takahiko Nakagawa
    Division of Nephrology, Hypertension and Transplantation, University of Florida, PO Box 100224, Gainesville, FL 32610 0224, USA
    J Am Soc Nephrol 18:539-50. 2007
    ..It was postulated that endothelial dysfunction should predict nephropathy and that correction of the dysfunction may prevent these important complications...
  5. pmc Resveratrol alleviates cardiac dysfunction in streptozotocin-induced diabetes: Role of nitric oxide, thioredoxin, and heme oxygenase
    Mahesh Thirunavukkarasu
    Department of Surgery, Molecular Cardiology and Angiogenesis Laboratory, University of Connecticut Medical Center, 263 Farmington Avenue, Farmington, CT 06030 1110, USA
    Free Radic Biol Med 43:720-9. 2007
    ..Thus this study shows a novel mechanism of pharmacological preconditioning with resveratrol in the diabetic myocardium...
  6. ncbi Mechanisms underlying endothelial dysfunction in diabetes mellitus
    U Hink
    Universitatskrankenhaus Eppendorf, Germany
    Circ Res 88:E14-22. 2001
    ..The full text of this article is available at http://www.circresaha.org...
  7. ncbi Suppression of accelerated diabetic atherosclerosis by the soluble receptor for advanced glycation endproducts
    L Park
    Department of Surgery, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Nat Med 4:1025-31. 1998
    ....
  8. ncbi Abnormalities of retinal metabolism in diabetes and experimental galactosemia. VII. Effect of long-term administration of antioxidants on the development of retinopathy
    R A Kowluru
    Kresge Eye Institute, Wayne State University, Detroit, Michigan 48201, USA
    Diabetes 50:1938-42. 2001
    ..Supplementation with antioxidants can offer an achievable and inexpensive adjunct therapy to help inhibit the development of retinopathy in diabetes...
  9. ncbi Increased renal expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 in experimental diabetes
    M E Cooper
    Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, West Heidelberg, Victoria, Australia
    Diabetes 48:2229-39. 1999
    ..In addition, an early and transient increase in renal VEGF receptors was also observed in diabetic rats. These findings are consistent with a role for VEGF in mediating some of the changes observed in the diabetic kidney...
  10. ncbi Attenuation by metallothionein of early cardiac cell death via suppression of mitochondrial oxidative stress results in a prevention of diabetic cardiomyopathy
    Lu Cai
    Department of Medicine, The University of Louisville, Louisville, Kentucky, USA
    J Am Coll Cardiol 48:1688-97. 2006
    ..We aimed to test whether attenuation of early-phase cardiac cell death can prevent diabetic cardiomyopathy...
  11. ncbi Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates
    Bernhard J Hering
    Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, 424 Harvard Street SE, Minneapolis, Minnesota 55455, USA
    Nat Med 12:301-3. 2006
    ....
  12. pmc Experimental diabetes mellitus exacerbates tau pathology in a transgenic mouse model of Alzheimer's disease
    Yazi D Ke
    Alzheimer s and Parkinson s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Sydney, Australia
    PLoS ONE 4:e7917. 2009
    ..Hence, DM can accelerate onset and increase severity of disease in individuals with a predisposition to developing tau pathology...
  13. ncbi Proteasome-dependent degradation of guanosine 5'-triphosphate cyclohydrolase I causes tetrahydrobiopterin deficiency in diabetes mellitus
    Jian Xu
    Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Circulation 116:944-53. 2007
    ....
  14. ncbi Diabetes and advanced glycation endproducts
    H Vlassara
    Department of Geriatrics, Mount Sinai School of Medicine, NY 10029, USA
    J Intern Med 251:87-101. 2002
    ..The final disposal of AGE depends on renal clearance. Promising pharmacologic strategies to prevent AGE formation, reduce AGE toxicity, and/or inactivate AGE are under investigation...
  15. ncbi Characterization of susceptibility of inbred mouse strains to diabetic nephropathy
    Zhonghua Qi
    Veterans Administration Medical Center, Nashville, TN 37212, USA
    Diabetes 54:2628-37. 2005
    ..DBA/2J and KK/HlJ mice are more prone to diabetic nephropathy, whereas the most widely used C57BL/6J mice are relatively resistant to development of diabetic nephropathy...
  16. ncbi Hyperglycemia-induced apoptosis in mouse myocardium: mitochondrial cytochrome C-mediated caspase-3 activation pathway
    Lu Cai
    Department of Medicine, University of Louisville, Louisville, Kentucky, USA
    Diabetes 51:1938-48. 2002
    ..Hyperglycemia-induced myocardial apoptosis is mediated, at least in part, by activation of the cytochrome c-activated caspase-3 pathway, which may be triggered by ROS derived from high levels of glucose...
  17. ncbi A role for the polyol pathway in the early neuroretinal apoptosis and glial changes induced by diabetes in the rat
    Veronica Asnaghi
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Diabetes 52:506-11. 2003
    ..These findings have implications for how to evaluate the role of the polyol pathway in diabetic retinopathy...
  18. ncbi Aldose reductase inhibitor fidarestat prevents retinal oxidative stress and vascular endothelial growth factor overexpression in streptozotocin-diabetic rats
    Irina G Obrosova
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan Medical Center, 1150 West Medical Center Drive, MSRB II, Room 5570, Ann Arbor, MI 48109 0678, USA
    Diabetes 52:864-71. 2003
    ..In conclusion, increased AR activity contributes to retinal oxidative stress and VEGF protein overexpression in early diabetes. The findings justify the rationale for evaluation of fidarestat on diabetic retinopathy...
  19. ncbi Diabetes related cardiomyopathy time dependent echocardiographic evaluation in an experimental rat model
    M J Mihm
    Division of Pharmacology, College of Pharmacy, The Ohio State University, Columbus, USA
    Life Sci 69:527-42. 2001
    ..Furthermore, diastolic dysfunction precedes contractile abnormalities in the streptozotocin model, similar to events that occur in humans...
  20. ncbi Hyperglycemia in streptozotocin-induced diabetic rat increases infarct size associated with low levels of myocardial HO-1 during ischemia/reperfusion
    Clara Di Filippo
    Department of Experimental Medicine, Section of Pharmacology L Donatelli, Second University of Naples, Italy
    Diabetes 54:803-10. 2005
    ..This recovered the huge number of infiltrated polymorphonuclear (PMN) leukocytes within the cardiac tissue associated with the STZ hyperglycemic state and I/R damage...
  21. ncbi Salicylate-based anti-inflammatory drugs inhibit the early lesion of diabetic retinopathy
    Ling Zheng
    Department of Medicine and Ophthalmology, 434 Biomedical Research Building, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Diabetes 56:337-45. 2007
    ....
  22. pmc Ornithine decarboxylase, kidney size, and the tubular hypothesis of glomerular hyperfiltration in experimental diabetes
    S C Thomson
    Department of Medicine, Division of Nephrology Hypertension, University of California at San Diego and Veterans Affairs Medical Center, 3350 La Jolla Village Drive, San Diego, California 92161 9151, USA
    J Clin Invest 107:217-24. 2001
    ....
  23. ncbi Defective intracellular Ca(2+) signaling contributes to cardiomyopathy in Type 1 diabetic rats
    Kin M Choi
    Department of Pharmacology and Cell Biophysics, University of Cincinnati, Ohio 45267, USA
    Am J Physiol Heart Circ Physiol 283:H1398-408. 2002
    ..The increase in phospholamban, decrease in Na(+)/Ca(2+) exchanger, and unchanged L-type Ca(2+) channel activity in this model of diabetic cardiomyopathy are distinct from other types of cardiomyopathy...
  24. ncbi A breaker of advanced glycation end products attenuates diabetes-induced myocardial structural changes
    Riccardo Candido
    Division of Diabetes, Lipoproteins and Metabolism, Baker Heart Research Institute, Prahran, Victoria, Australia
    Circ Res 92:785-92. 2003
    ..This provides a potential new therapeutic approach for cardiovascular disease in human diabetes...
  25. ncbi Effect of long-term administration of alpha-lipoic acid on retinal capillary cell death and the development of retinopathy in diabetic rats
    Renu A Kowluru
    Kresge Eye Institute, Wayne State University, Detroit, MI 48201, USA
    Diabetes 53:3233-8. 2004
    ..alpha-Lipoic acid supplementation represents an achievable adjunct therapy to help prevent vision loss in diabetic patients...
  26. ncbi Effects of antioxidants in diabetes-induced oxidative stress in the glomeruli of diabetic rats
    Daisuke Koya
    Department of Medicine, Shiga University of Medical Science, Shiga, Japan
    J Am Soc Nephrol 14:S250-3. 2003
    ..In summary, oxidative stress by diabetes could play a crucial role in the development and progression of diabetic nephropathy, and antioxidant treatment could be a potential therapeutic procedure for diabetic nephropathy...
  27. ncbi Heme oxygenase-mediated increases in adiponectin decrease fat content and inflammatory cytokines tumor necrosis factor-alpha and interleukin-6 in Zucker rats and reduce adipogenesis in human mesenchymal stem cells
    Dong Hyun Kim
    Dept of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    J Pharmacol Exp Ther 325:833-40. 2008
    ..These findings highlight the pivotal role and symbiotic relationship of HO-1 and adiponectin in the modulation of the metabolic syndrome phenotype...
  28. pmc Aldose reductase inhibitor fidarestat counteracts diabetes-associated cataract formation, retinal oxidative-nitrosative stress, glial activation, and apoptosis
    Viktor R Drel
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Int J Mol Med 21:667-76. 2008
    ....
  29. pmc PGC-1alpha is a key regulator of glucose-induced proliferation and migration in vascular smooth muscle cells
    Lingyun Zhu
    Jiangsu Diabetes Center, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, People s Republic of China
    PLoS ONE 4:e4182. 2009
    ..This study was performed to investigate whether PGC-1alpha, a PPARgamma coactivator and metabolic master regulator, plays a role in regulating VSMC proliferation and migration induced by high glucose...
  30. ncbi A role for mitogen-activated protein kinases in the etiology of diabetic neuropathy
    T Purves
    Neuroscience Division, School of Biological Sciences, University of Manchester, Manchester, UK
    FASEB J 15:2508-14. 2001
    ..These data implicate MAPKs in the etiology of diabetic neuropathy both via direct effects of glucose and via glucose-induced oxidative stress...
  31. ncbi p27 Regulates the transition of beta-cells from quiescence to proliferation
    Senta Georgia
    Larry Hillblom Islet Research Center, University of California, Los Angeles, 900A Weyburn Pl, Los Angeles, CA 90095, USA
    Diabetes 55:2950-6. 2006
    ..These data indicate that p27 is a key regulator in establishing beta-cell mass and an important target for facilitating beta-cell regeneration in therapies for diabetes...
  32. pmc Protective effect of perindopril on diabetic retinopathy is associated with decreased vascular endothelial growth factor-to-pigment epithelium-derived factor ratio: involvement of a mitochondria-reactive oxygen species pathway
    Zhi Zheng
    Department of Ophthalmology, First People s Hospital of Shanghai, Shanghai Jiaotong University, Shanghai, China
    Diabetes 58:954-64. 2009
    ....
  33. pmc Genetic difference in susceptibility to the blood-retina barrier breakdown in diabetes and oxygen-induced retinopathy
    Sarah X Zhang
    Department of Medicine, The Oklahoma University Health Science Center, 941 Stanton L Young Blvd, BSEB 328B, Oklahoma City, OK 73104 5043, USA
    Am J Pathol 166:313-21. 2005
    ..This finding suggests that genetic backgrounds contribute to the susceptibility to diabetic retinopathy...
  34. ncbi N-acetylcysteine prevents nitrosative stress-associated depression of blood pressure and heart rate in streptozotocin diabetic rats
    Prabhakara Reddy Nagareddy
    Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada
    J Cardiovasc Pharmacol 47:513-20. 2006
    ..The results suggest that nitrosative stress depress MABP and HR following diabetes. Further studies are required to elucidate the mechanisms involved in nitrosative stress mediated depression of blood pressure and heart rate...
  35. ncbi Receptor for advanced glycation end products is involved in impaired angiogenic response in diabetes
    Takuhito Shoji
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Osaka 545 8585, Japan
    Diabetes 55:2245-55. 2006
    ..Thus, RAGE appears to be involved in impairment of angiogenesis in diabetes, and blockade of RAGE might be a potential therapeutic target...
  36. ncbi Generation of insulin-producing cells from human bone marrow mesenchymal stem cells by genetic manipulation
    Ohad Karnieli
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel
    Stem Cells 25:2837-44. 2007
    ..These findings were reproducible in BM-MSC from 9 of 14 donors of both sexes, ages 19-62. These results suggest a therapeutic potential for PDX1-expressing BM-MSC in beta-cell replacement in patients with type 1 diabetes...
  37. ncbi Effects of aliskiren on blood pressure, albuminuria, and (pro)renin receptor expression in diabetic TG(mRen-2)27 rats
    David L Feldman
    Novartis Institutes for BioMedical Research, Bldg 437, Rm 3317, One Health Plaza, E Hanover, NJ 07936, USA
    Hypertension 52:130-6. 2008
    ....
  38. ncbi Absence of inducible nitric oxide synthase reduces myocardial damage during ischemia reperfusion in streptozotocin-induced hyperglycemic mice
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    Diabetes 53:454-62. 2004
    ..The beneficial role of iNOS in modulating defensive responses against ischemia/reperfusion injury seems to be abolished in diabetic mice...
  39. pmc Dissociation of thermal hypoalgesia and epidermal denervation in streptozotocin-diabetic mice
    Kristina K Beiswenger
    Department of Pathology 0612, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0612, United States
    Neurosci Lett 442:267-72. 2008
    ..These data suggest that impaired epidermal nociceptor function contributes to early diabetes-induced thermal hypoalgesia prior to the loss of peripheral terminals...
  40. ncbi Poly(ADP-ribose)polymerase inhibition counteracts cataract formation and early retinal changes in streptozotocin-diabetic rats
    Viktor R Drel
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808, USA
    Invest Ophthalmol Vis Sci 50:1778-90. 2009
    ..This study evaluated the role for poly(ADP-ribose) polymerase (PARP) in diabetes-induced cataractogenesis and early retinal changes...
  41. ncbi Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice
    Mengwei Zang
    Vascular Biology Unit, Boston University Medical Center, 650 Albany St, X704, MA 02118, USA
    Diabetes 55:2180-91. 2006
    ....
  42. ncbi Curcumin attenuates thermal hyperalgesia in a diabetic mouse model of neuropathic pain
    Sameer Sharma
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India
    Eur J Pharmacol 536:256-61. 2006
    ..These results indicate an antinociceptive activity of curcumin possibly through its inhibitory action on NO and TNF-alpha release and point towards its potential to attenuate diabetic neuropathic pain...
  43. pmc IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat
    J A Ehses
    Division of Endocrinology, Diabetes, and Nutrition and Center for Integrated Human Physiology, University Hospital of Zurich, 8045 Zurich, Switzerland
    Proc Natl Acad Sci U S A 106:13998-4003. 2009
    ..Rather than being directly cytotoxic, IL-1beta may drive tissue inflammation that impacts on both beta cell functional mass and insulin sensitivity in type 2 diabetes...
  44. pmc Exposure to maternal diabetes induces salt-sensitive hypertension and impairs renal function in adult rat offspring
    Touria Nehiri
    Institut National de la Sante et de la Recherche Medicale, Unite Mixte de Recherche S872, Centre de Recherche des Cordeliers, Paris, France
    Diabetes 57:2167-75. 2008
    ..The aim of the study was to assess, in the rat, long-term effects of in utero exposure to maternal diabetes on blood pressure and renal function in adulthood...
  45. ncbi Anti-diabetic activity of green tea polyphenols and their role in reducing oxidative stress in experimental diabetes
    M C Sabu
    Amala Cancer Research Centre, Amala Nagar, Trichur 680 553, Kerala, India
    J Ethnopharmacol 83:109-16. 2002
    ..These results indicate that alterations in the glucose utilizing system and oxidation status in rats increased by alloxan were partially reversed by the administration of the glutamate pyruvate transaminase...
  46. ncbi The genetic landscape of type 2 diabetes in mice
    Susanne M Clee
    Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Drive, Madison, Wisconsin 53706 1544, USA
    Endocr Rev 28:48-83. 2007
    ....
  47. ncbi Macrophages in streptozotocin-induced diabetic nephropathy: potential role in renal fibrosis
    Fiona Y Chow
    Department of Nephrology, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria 3168, Australia
    Nephrol Dial Transplant 19:2987-96. 2004
    ....
  48. ncbi IHG-2, a mesangial cell gene induced by high glucose, is human gremlin. Regulation by extracellular glucose concentration, cyclic mechanical strain, and transforming growth factor-beta1
    R McMahon
    Conway Institute of Biomolecular and Biomedical Research, Department of Medicine and Therapeutics, University College Dublin, Mater Misericordiae Hospital, Dublin 7, Ireland
    J Biol Chem 275:9901-4. 2000
    ....
  49. ncbi Folic acid supplementation diminishes diabetes- and glucose-induced dysmorphogenesis in rat embryos in vivo and in vitro
    Parri Wentzel
    Department of Medical Cell Biology, Uppsala University, Biomedical Center, P O Box 571, SE 751 23 Uppsala, Sweden
    Diabetes 54:546-53. 2005
    ..The present work shows that administration of folic acid can diminish diabetes-induced maldevelopment. This suggests that folic acid supplementation may have a role in the prevention of malformations in diabetic pregnancy...
  50. ncbi Direct insulin signaling of neurons reverses diabetic neuropathy
    Valentine Brussee
    Department of Clinical Neurosciences and the Neuroscience Research Group, University of Calgary, Calgary, Alberta, Canada
    Diabetes 53:1824-30. 2004
    ..Defective direct signaling of insulin on peripheral neurons through routes that include the cerebrospinal fluid may relate to the development of diabetic peripheral neuropathy...
  51. ncbi Tumstatin peptide, an inhibitor of angiogenesis, prevents glomerular hypertrophy in the early stage of diabetic nephropathy
    Yoshihiko Yamamoto
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama, 700 8558, Japan
    Diabetes 53:1831-40. 2004
    ..Taken together, these results demonstrate the potential use of antiangiogenic tumstatin peptide as a novel therapeutic agent in early diabetic nephropathy...
  52. ncbi Antioxidant treatment attenuates hyperglycemia-induced cardiomyocyte death in rats
    Fabio Fiordaliso
    Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milan, Italy
    J Mol Cell Cardiol 37:959-68. 2004
    ..NAC effectively protects from hyperglycemia-induced myocyte cell death and compensatory hypertrophy through direct scavenging of ROS and replenishment of the intracellular glutathione content...
  53. ncbi Diabetes-induced mitochondrial dysfunction in the retina
    Renu A Kowluru
    Kresge Eye Institute, Wayne State University, 4717 St Antoine, Detroit, MI 48201, USA
    Invest Ophthalmol Vis Sci 44:5327-34. 2003
    ..The purpose of this study was to investigate the effect of diabetes on the release of cytochrome c from mitochondria and translocation of Bax into mitochondria in the rat retina and in the isolated retinal capillary cells...
  54. ncbi CREB regulates hepatic gluconeogenesis through the coactivator PGC-1
    S Herzig
    Peptide Biology Laboratories, Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, California 92037 1002, USA
    Nature 413:179-83. 2001
    ..Fasting hyperglycaemia is strongly correlated with type II diabetes, so our results suggest that the activation of PGC-1 by CREB in liver contributes importantly to the pathogenesis of this disease...
  55. pmc Rho kinase inhibition by fasudil ameliorates diabetes-induced microvascular damage
    Ryoichi Arita
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Diabetes 58:215-26. 2009
    ..Involvement of the Rho/Rho kinase (ROCK) pathway in diabetic microvasculopathy and therapeutic potential of fasudil, a selective ROCK inhibitor, are investigated...
  56. ncbi Curcumin attenuates diabetic encephalopathy in rats: behavioral and biochemical evidences
    Anurag Kuhad
    Pharmacology Research Laboratory, University Institute of Pharmaceutical Sciences, UGC Center for Advanced Studies, Panjab University, Chandigarh 160 014, India
    Eur J Pharmacol 576:34-42. 2007
    ....
  57. pmc Experimental diabetes in rats causes hippocampal dendritic and synaptic reorganization and increased glucocorticoid reactivity to stress
    A M Magarinos
    The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 97:11056-61. 2000
    ....
  58. ncbi Response of capillary cell death to aminoguanidine predicts the development of retinopathy: comparison of diabetes and galactosemia
    T S Kern
    Departments of Medicine, Ophthalmology, Pharmacology and Center for Diabetes Research, Case Western Reserve University, Cleveland, Ohio, USA
    Invest Ophthalmol Vis Sci 41:3972-8. 2000
    ..To examine the relationship between early retinal capillary cell apoptosis and late histologic lesions of diabetic retinopathy and to compare the effects of aminoguanidine (AMG) on the retinopathies caused by diabetes and galactose feeding...
  59. ncbi Neuronal death in the rat hippocampus in experimental diabetes and cerebral ischaemia treated with antioxidants
    P Piotrowski
    Department of Neuropathology, Medical Research Centre, Polish Academy of Sciences, Warszawa
    Folia Neuropathol 39:147-54. 2001
    ..The above results of CPP32 activity suggest an important role of apoptosis as a mechanism of cell death and demonstrate the positive effect of the CoQ10 and the LA treatment...
  60. pmc Improvement of vascular function by acute and chronic treatment with the PDE-5 inhibitor sildenafil in experimental diabetes mellitus
    A Schafer
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Julius Maximilians Universitat Wurzburg, Wurzburg, Bavaria, Germany
    Br J Pharmacol 153:886-93. 2008
    ..Diabetes-associated vascular dysfunction contributes to increased cardiovascular risk. We investigated whether the phosphodiesterase-5 inhibitor sildenafil would improve vascular function in diabetic rats...
  61. ncbi Nitric oxide may prevent hypertension early in diabetes by counteracting renal actions of superoxide
    Michael W Brands
    Department of Physiology and the Vascular Biology Center, Medical College of Georgia, CL 3132, Augusta, GA 30912 3000, USA
    Hypertension 43:57-63. 2004
    ..Thus, the hypertension and decrease in GFR caused by onset of diabetes in rats without a functioning nitric oxide system was prevented by chronic administration of the superoxide dismutase mimetic tempol...
  62. pmc Combination therapy with AT1 blocker and vitamin D analog markedly ameliorates diabetic nephropathy: blockade of compensatory renin increase
    Zhongyi Zhang
    Department of Medicine, Division of Biological Sciences, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 105:15896-901. 2008
    ..These data demonstrate that inhibition of the RAS with combination of vitamin D analogs and RAS inhibitors effectively prevents renal injury in diabetic nephropathy...
  63. ncbi Receptor for advanced glycation end products (RAGEs) and experimental diabetic neuropathy
    Cory Toth
    University of Calgary, Department of Clinical Neurosciences, Room 155, 3330 Hospital Dr, N W, Calgary, Alberta T2N 4N1, Canada
    Diabetes 57:1002-17. 2008
    ..We studied experimental diabetic neuropathy and its relationship with RAGE expression using streptozotocin-induced diabetic mice including a RAGE(-/-) cohort exposed to long-term diabetes compared with littermates without diabetes...
  64. ncbi Effects of balloon injury on neointimal hyperplasia in streptozotocin-induced diabetes and in hyperinsulinemic nondiabetic pancreatic islet-transplanted rats
    C Indolfi
    Division of Cardiology, University Federico II, and the National Cancer Institute, Naples, Italy
    Circulation 103:2980-6. 2001
    ..The mechanisms of increased neointimal hyperplasia after coronary interventions in diabetic patients are still unknown...
  65. ncbi Rodent models of streptozotocin-induced diabetic nephropathy
    Greg H Tesch
    Department of Nephrology, Monash University, Monash Medical Centre, Clayton, Victoria, Australia
    Nephrology (Carlton) 12:261-6. 2007
    ....
  66. pmc Hyperglycemia-induced reactive oxygen species increase expression of the receptor for advanced glycation end products (RAGE) and RAGE ligands
    Dachun Yao
    Department of Medicine, Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York, USA
    Diabetes 59:249-55. 2010
    ..Since hyperglycemia-induced reactive oxygen species (ROS) activate many pathways of diabetic tissue damage, the effect of these ROS on RAGE and RAGE ligand expression was evaluated...
  67. ncbi Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
    J C Yoon
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 413:131-8. 2001
    ..These results implicate PGC-1 as a key modulator of hepatic gluconeogenesis and as a central target of the insulin-cAMP axis in liver...
  68. ncbi Baicalein reduces inflammatory process in a rodent model of diabetic retinopathy
    Li Ping Yang
    Peking University Eye Center, Peking University Third Hospital, Peking University, Beijing, PR China
    Invest Ophthalmol Vis Sci 50:2319-27. 2009
    ..This study was designed to elucidate the role of inflammatory process in diabetic retinopathy and to investigate the effect of baicalein treatment on diabetic rat...
  69. ncbi Suppression of Fas-FasL-induced endothelial cell apoptosis prevents diabetic blood-retinal barrier breakdown in a model of streptozotocin-induced diabetes
    Antonia M Joussen
    Retina Research Institute, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    FASEB J 17:76-8. 2003
    ..These data imply that the targeting of the Fas-FasL pathway may prove beneficial in the treatment of diabetic retinopathy...
  70. ncbi Modulatory effects of resveratrol on attenuating the key enzymes activities of carbohydrate metabolism in streptozotocin-nicotinamide-induced diabetic rats
    P Palsamy
    Research Scholar, Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600025, Tamilnadu, India
    Chem Biol Interact 179:356-62. 2009
    ..Thus, the modulatory effects of resveratrol on attenuating these enzymes activities afford a promise for widespread use for treatment of diabetes in the future...
  71. ncbi Integrin-mediated neutrophil adhesion and retinal leukostasis in diabetes
    F C Barouch
    Laboratory for Surgical Research, Children s Hospital, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 41:1153-8. 2000
    ..In vivo, CD18 blockade significantly decreases leukostasis in the diabetic retinal microvasculature. Integrin adhesion molecules may serve as therapeutic targets for the treatment and/or prevention of early diabetic retinopathy...
  72. ncbi Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1
    Jun Nakae
    Naomi Berrie Diabetes Center, Berrie Research Pavilion, 1150 St Nicholas Avenue, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Nat Genet 32:245-53. 2002
    ..This has been corrected in the full-text online version of the article. The name will appear correctly in the print version...
  73. pmc Effect of the monocyte chemoattractant protein-1/CC chemokine receptor 2 system on nephrin expression in streptozotocin-treated mice and human cultured podocytes
    Elena Tarabra
    Diabetic Nephropathy Laboratory, Department of Internal Medicine, University of Turin, Italy
    Diabetes 58:2109-18. 2009
    ..Moreover, we investigated in vivo if glomerular CCR2 expression is altered in kidney biopsies from patients with diabetic nephropathy and whether lack of MCP-1 affects proteinuria and expression of nephrin in experimental diabetes...
  74. ncbi VEGF164 is proinflammatory in the diabetic retina
    Susumu Ishida
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 44:2155-62. 2003
    ....
  75. ncbi Regeneration of the heart in diabetes by selective copper chelation
    Garth J S Cooper
    Level 4, Thomas Building, School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Diabetes 53:2501-8. 2004
    ..These data implicate accumulation of elevated loosely bound Cu in the mechanism of cardiac damage in diabetes and support the use of selective Cu chelation in the treatment of this condition...
  76. ncbi Merit of Astragalus polysaccharide in the improvement of early diabetic nephropathy with an effect on mRNA expressions of NF-kappaB and IkappaB in renal cortex of streptozotoxin-induced diabetic rats
    Ying Wen Zhang
    Department of Chinese with Western Medicine, Zhongnan Hospital, Wuhan University, Wuhan 430071, PR China
    J Ethnopharmacol 114:387-92. 2007
    ....
  77. ncbi Interference with TGF-beta signaling by Smad3-knockout in mice limits diabetic glomerulosclerosis without affecting albuminuria
    Amy Wang
    Division of Nephrology, Northwestern University, 303 E Chicago Ave, Tarry 4 755, Chicago, IL 60611, USA
    Am J Physiol Renal Physiol 293:F1657-65. 2007
    ..In conclusion, the effects of the Smad3-KO mirror the effects of anti-TGF-beta therapy in diabetes, suggesting that the chief component of TGF-beta signaling that is relevant to kidney disease is the Smad3 pathway...
  78. pmc Oxidative-nitrosative stress and poly(ADP-ribose) polymerase (PARP) activation in experimental diabetic neuropathy: the relation is revisited
    Irina G Obrosova
    Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Rd, Baton Rouge, Louisiana 70808, USA
    Diabetes 54:3435-41. 2005
    ..The relations between oxidative-nitrosative stress and PARP activation in diabetes are bi- rather than unidirectional, and PARP activation cannot only result from but also lead to free radical and oxidant generation...
  79. pmc Altered calcium homeostasis does not explain the contractile deficit of diabetic cardiomyopathy
    Lin Zhang
    Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Diabetes 57:2158-66. 2008
    ..This study examines the extent to which the contractile deficit of diabetic cardiomyopathy is due to altered Ca(2+) homeostasis...
  80. pmc Protein kinase B/Akt activity is involved in renal TGF-beta1-driven epithelial-mesenchymal transition in vitro and in vivo
    Jayesh J Kattla
    UCD Diabetic Research Centre, School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland
    Am J Physiol Renal Physiol 295:F215-25. 2008
    ..Together, these data suggest that TGF-beta1-mediated PKB/Akt activation may be important in renal fibrosis during diabetic nephropathy...
  81. ncbi Contributions of polyol pathway to oxidative stress in diabetic cataract
    A Y Lee
    a Institute of Molecular Biology, University of Hong Kong, Pokfulam, Hong Kong, People s Republic of China
    FASEB J 13:23-30. 1999
    ..Lee, A. Y. W., Chung, S. S. M. Contributions of polyol pathway to oxidative stress in diabetic cataract. FASEB J. 13, 23-30 (1999)..
  82. ncbi Sirolimus is associated with reduced islet engraftment and impaired beta-cell function
    Nan Zhang
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Diabetes 55:2429-36. 2006
    ..These data suggest that sirolimus, administered in the early posttransplantation phase, is a confounding factor for reduced islet engraftment and impaired beta-cell function in transplants...
  83. ncbi Anti-diabetic activity of medicinal plants and its relationship with their antioxidant property
    M C Sabu
    Amala Cancer Research Centre, Amala Nagar, Kerala Trichur 680 553, India
    J Ethnopharmacol 81:155-60. 2002
    ..Continued, daily administration of the drug produced a sustained effect...
  84. ncbi Salutary effect of pigment epithelium-derived factor in diabetic nephropathy: evidence for antifibrogenic activities
    Joshua J Wang
    Department of Medicine Endocrinology, University of Oklahoma Health Sciences Ceter, Oklahoma City, Oklahoma, USA
    Diabetes 55:1678-85. 2006
    ....
  85. ncbi A metalloporphyrin-based superoxide dismutase mimic inhibits adoptive transfer of autoimmune diabetes by a diabetogenic T-cell clone
    Jon D Piganelli
    Department of Immunology, University of Colorado Health Sciences Center and Barbara Davis Center for Childhood Diabetes, Denver, Colorado, USA
    Diabetes 51:347-55. 2002
    ..Finally, this compound protected NIT-1 insulinoma cells from interleukin-1beta and alloxan cytotoxicity in vitro...
  86. pmc Aldose reductase inhibition counteracts oxidative-nitrosative stress and poly(ADP-ribose) polymerase activation in tissue sites for diabetes complications
    Irina G Obrosova
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Diabetes 54:234-42. 2005
    ..These findings reveal the new beneficial properties of fidarestat, thus further justifying the ongoing clinical trials of this specific, potent, and low-toxic ARI...
  87. ncbi Topical administration of nepafenac inhibits diabetes-induced retinal microvascular disease and underlying abnormalities of retinal metabolism and physiology
    Timothy S Kern
    Medicine and Ophthalmology, 434 Biomedical Research Building, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA
    Diabetes 56:373-9. 2007
    ..Local inhibition of inflammatory pathways in the eye offers a novel therapeutic approach toward inhibiting the development of lesions of diabetic retinopathy...
  88. ncbi The effect of nimodipine on calcium homeostasis and pain sensitivity in diabetic rats
    L Shutov
    Bogomoletz Institute of Physiology, Kiev, Ukraine
    Cell Mol Neurobiol 26:1541-57. 2006
    ..The nimodipine effect is mediated through a direct neuronal action combined with some vascular mechanism...
  89. ncbi Recovery of islet beta-cell function in streptozotocin- induced diabetic mice: an indirect role for the spleen
    Dengping Yin
    Section of Transplantation, Department of Surgery, The University of Chicago, Chicago, IL 60637, USA
    Diabetes 55:3256-63. 2006
    ..This study supports the possibility of restoring beta-cell function in diabetic individuals and points to a role for the spleen in facilitating this process...
  90. ncbi Effects of silymarin (hepatoprotector) and succinic acid (bioenergy regulator) on metabolic disorders in experimental diabetes mellitus
    A I Vengerovskii
    Department of Pharmacology, Siberian State Medical University, Tomsk
    Bull Exp Biol Med 144:53-6. 2007
    ..mg/kg) reduce blood glucose and cholesterol concentrations, inhibit LPO, and correct oxidative phosphorylation disturbances in liver mitochondria in experimental diabetes mellitus induced by injection of streptozotocin (65 mg/kg) in rats.
  91. ncbi Experimental diabetes mellitus down-regulates large-conductance Ca2+-activated K+ channels in cerebral artery smooth muscle and alters functional conductance
    Yan Wang
    Department of Physiology and Pathophysiology, Xi an Jiaotong University School of Medicine, 76 West Yanta Road, Xi an, 710061, Shaanxi, China
    Curr Neurovasc Res 7:75-84. 2010
    ....
  92. ncbi The hypoglycemic effects of hesperidin and naringin are partly mediated by hepatic glucose-regulating enzymes in C57BL/KsJ-db/db mice
    Un Ju Jung
    Department of Food Science and Nutrition, Kyungpook National University, Daegu, 702 701, Korea
    J Nutr 134:2499-503. 2004
    ....
  93. ncbi Hypoglycaemic effect of water extracts of Aegle marmelos fruits in streptozotocin diabetic rats
    N Kamalakkannan
    Department of Biochemistry, Annamalai University, Annamalai Nagar, Tamil Nadu, 608002, India
    J Ethnopharmacol 87:207-10. 2003
    ..The effect of the extract at a dose of 250mgkg(-1) was more effective than glibenclamide in restoring the values of these parameters. The results of this study clearly shows the hypoglycaemic activity of the fruit extract...
  94. pmc Reversal of experimental diabetic neuropathy by VEGF gene transfer
    P Schratzberger
    Division of Cardiovascular Research, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA
    J Clin Invest 107:1083-92. 2001
    ....
  95. ncbi Differential importance of glucose-dependent insulinotropic polypeptide vs glucagon-like peptide 1 receptor signaling for beta cell survival in mice
    Adriano Maida
    Department of Medicine, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Gastroenterology 137:2146-57. 2009
    ....
  96. pmc Age-dependent decline in beta-cell proliferation restricts the capacity of beta-cell regeneration in mice
    Shuen Ing Tschen
    Larry L Hillblom Islet Research Center, Department of Medicine, University of California, Los Angeles, Los Angeles, California, USA
    Diabetes 58:1312-20. 2009
    ..The aim of this study was to elucidate whether age plays a role in the expansion or regeneration of beta-cell mass...
  97. ncbi Role of sterol regulatory element-binding protein 1 in regulation of renal lipid metabolism and glomerulosclerosis in diabetes mellitus
    Lijun Sun
    Department of Medicine and Pathology, The University of Texas Southwestern Medical Center, Veterans Affairs Medical Center, Dallas, Texas 75216, USA
    J Biol Chem 277:18919-27. 2002
    ....
  98. ncbi Downregulation of NADPH oxidase, antioxidant enzymes, and inflammatory markers in the heart of streptozotocin-induced diabetic rats by N-acetyl-L-cysteine
    Zhixin Guo
    Faculty of Pharmaceutical Sciences, Div of Pharmacology and Toxicology, The Univ of British Columbia, Vancouver, BC, Canada
    Am J Physiol Heart Circ Physiol 292:H1728-36. 2007
    ..The protective effects of NAC on diabetic rat hearts may be attributable to its protection of hearts against oxidative damage induced by the increased NADPH oxidase and to its reduction in cardiac inflammatory mediators IL-6 and COX-2...
  99. ncbi Long-term effects of maternal diabetes on vascular reactivity and renal function in rat male offspring
    Silvia O Rocha
    Department of Physiology, Federal University of Sao Paulo, Brazil
    Pediatr Res 58:1274-9. 2005
    ....
  100. ncbi Antioxidant mechanism of heme oxygenase-1 involves an increase in superoxide dismutase and catalase in experimental diabetes
    Saadet Turkseven
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 289:H701-7. 2005
    ..These observations in experimental diabetes suggest that the vascular cytoprotective mechanism of HO-1 against oxidative stress requires an increase in EC-SOD and catalase...
  101. ncbi Differential effects of diabetes on the expression of the gp91phox homologues nox1 and nox4
    Maria C Wendt
    The University Clinics Eppendorf, Division of Cardiology, Hamburg, Germany
    Free Radic Biol Med 39:381-91. 2005
    ..We conclude that in addition to phagocytic NADPH oxidase, also nonphagocytic, vascular NADPH oxidase subunit nox1, uncoupled NOSIII, and plasma xanthine oxidase contribute to endothelial dysfunction in the setting of diabetes mellitus...

Research Grants69

  1. Massively Parallel Gene Expression Analysis
    Richard Quigg; Fiscal Year: 2003
    ..and models in humans, animals and homogenous cells: 1) Nephropathy occurring during the course of experimental diabetes mellitus in mice; 2) Lymphocytic abnormalities in mice with experimental inflammatory bowel disease (IBD); 3) ..
  2. NEUROENDOCRINE CONTROL OF SMALL INTESTINAL MOTILITY
    Thomas Nowak; Fiscal Year: 1990
    ..A final study examines enteric neuromuscular transmission in experimental diabetes mellitus. Neuropeptides release is studied in streptozotocin-treated rats, controls, and insulin-treated ..
  3. EXPERIMENTAL DIABETES IN PREGNANCY
    RONALD BECK; Fiscal Year: 1980
    Pregnant rabbits will be injected with alloxan on the 5th gestational day in order to produce experimental diabetes mellitus. The chronic effects of varying degrees of diabetes on the maternal, fetal and neonatal production of adrenal ..
  4. IMMUNE FUNCTION IN EXPERIMENTAL DIABETES MELLITUS
    Barry Handwerger; Fiscal Year: 1980
    ..To demonstrate whether the alterations in immunological function which occur in experimental diabetes mellitus are a direct consequence of the abnormal in vivo metabolic milieu or whether they result from an ..
  5. Gene Gun Technology, Opioids, and Corneal Diseases
    IAN ZAGON; Fiscal Year: 2003
    ..Ultimately, such data can be employed to design molecular strategies to remedy visual dysfunction. ..
  6. Peroxynitrite decomposition catalyst:diabetic neuropathy
    IRINA OBROSOVA; Fiscal Year: 2006
    ..abstract_text> ..
  7. Poly(ADP-ribose) polymerase in diabetic nephropathy
    IRINA OBROSOVA; Fiscal Year: 2006
    ..abstract_text> ..
  8. Ketosis, Vascular Inflammation and Its Therapy in Type 1 Diabetic Patients
    Sushil K Jain; Fiscal Year: 2010
    ..The long-term goal is to understand the role of ketosis in CVD and to discover a relatively low-cost dietary supplement that could be used as an adjuvant therapy for CVD prevention in type 1 diabetes. ..
  9. Point-of-Care Measurement of Glycated Hemoglobin
    MARGO COHEN; Fiscal Year: 2004
    ....
  10. LDL Modification in Diabetic Complications
    MARGO COHEN; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  11. Adjuvant Therapy for Vascular Inflammation in Diabetes
    Sushil Jain; Fiscal Year: 2006
    ..abstract_text> ..
  12. Reducing Renal TGF-B in Diabetic Glomerulosclerosis
    MARGO COHEN; Fiscal Year: 2005
    ..abstract_text> ..
  13. Angiotensin II Mediates Early Changes in Diabetic Kidney
    Helmy Siragy; Fiscal Year: 2007
    ..The proposed studies will help understand the mechanisms that are involved in diabetic the development of new therapeutic modalities to prevent or slowdown the development ..
  14. Assessment of Altered Function in Diabetic Bladder
    Firouz Daneshgari; Fiscal Year: 2005
    ....
  15. Conference--National Urology Resident Female Pelvic Med
    Firouz Daneshgari; Fiscal Year: 2006
    ..abstract_text> ..
  16. AT2 Receptor Modulates Renal Angiotensin II Levels
    Helmy Siragy; Fiscal Year: 2005
    ..Data obtained from this proposal will lead to increased understanding of the pathophysiology of hypertension and development of novel therapies for its management. ..
  17. Manganese-enhanced MRI Studies of Retinal Neovascularization
    BRUCE BERKOWITZ; Fiscal Year: 2008
    ..The novel methods in this application will also contribute to the advancement of functional MRI for the study of retinal diseases. [unreadable] [unreadable] [unreadable]..
  18. PKC ALTERATIONS IN LUT DYSFUNCTION
    Firouz Daneshgari; Fiscal Year: 2004
    ..abstract_text> ..
  19. Retinal Oxygenation in Diabetic Retinopathy
    BRUCE BERKOWITZ; Fiscal Year: 2004
    ..The results of these studies could lead to the development of a non-invasive real time method for the early evaluation of diabetic retinopathy and its treatment. ..
  20. MR STUDIES OF EXPERIMENTAL RETINOPATHY OF PREMATURITY
    BRUCE BERKOWITZ; Fiscal Year: 2001
    ..This work may have broad impact beyond ROP since abnormal blood vessel growth is a common pathobiologic event for other blinding disorders, such as diabetic retinopathy. ..
  21. Mechanisms of Vaginal Sling Effects on Continence
    Firouz Daneshgari; Fiscal Year: 2006
    ..The long-term goal of this proposal is to expand the findings of this project into an R01 application in order to translate our findings into relevant clinical studies. [unreadable] [unreadable]..
  22. PROSAPOSIN AND PROSAPTIDES IN DIABETIC NEUROPATHY
    NIGEL CALCUTT; Fiscal Year: 2002
    ..The goal is to establish prosaptides as novel therapeutic agents for treating diabetic neuropathy and to provide mechanistic explanations for why hyperglycemia causes nerve disorders. ..
  23. Mg2+ homeostasis in liver cells treated with EtOH
    Andrea Romani; Fiscal Year: 2009
    ....
  24. Periodontal Disease and Rheumatoid Arthritis
    Michael McCracken; Fiscal Year: 2005
    ..Furthermore, it is hypothesized that among patients with rheumatoid arthritis, an association exists between the rate of progression of inflammatory arthritis and the progression of periodontal disease. ..
  25. Bile Acid and Estrogen Receptors in Colon Cancer
    Steven Kliewer; Fiscal Year: 2009
    ..Moreover, since both FXR and ERbeta can be regulated by small molecule ligands, these studies may reveal novel opportunities for treating and preventing colon cancer. ..
  26. ETHANOL, INSULIN/IGF SIGNALING AND NEURONAL MIGRATION
    Suzanne de la Monte; Fiscal Year: 2008
    ..abstract_text> ..
  27. Mixed Chimerism in Haploidentical Non-human Primates
    Bernhard Hering; Fiscal Year: 2006
    ..abstract_text> ..
  28. ANIMAL RESOURCES FACILITY EQUIPMENT IMPROVED PROJECT
    George King; Fiscal Year: 2004
    ..Not only will the requested improvements impact animal welfare, but they will also benefit the efficiency of the research animal program. ..
  29. Renal 11b-Hydroxysteroid Dehydrogenases and Hypertension
    Mingyu Liang; Fiscal Year: 2008
    ..The results are expected to elucidate a novel aspect of the pathophysiology of salt- sensitive hypertension and to provide potential new targets for prevention and treatment of hypertension. ..
  30. Ceruloplasmin Mediated Penile Endothelial Dysfunction in Type 1 Diabetes
    Kanchan Chitaley; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  31. Novel regulation of adipogenesis: agouti & melanocortins
    Randall Mynatt; Fiscal Year: 2007
    ..abstract_text> ..
  32. Sequence Distribution of Tabacco Carcinogen-DNA Adducts
    Natalia Tretyakova; Fiscal Year: 2007
    ..The proposed research is significant because of the widespread human exposure to tobacco products and because of their central role in the initiation of lung cancer in humans. ..
  33. Mitochondrial Cytoprotection to Prevent Islet Cell Death
    Dolca Thomas; Fiscal Year: 2007
    ..It is our expectation that as a result of our systematic investigation, we will gain knowledge translatable to the clinical islet transplantation trials in patients with type 1 diabetes. [unreadable] [unreadable]..
  34. CD8 T Cell Reactivity to IGRP as an Autoimmunity Marker in Type 1 Diabetes
    Teresa Dilorenzo; Fiscal Year: 2007
    ..Tests may also be developed to monitor destructive T cell activity in patients undergoing treatment, so that doctors will be able to know if the treatments are working. [unreadable] [unreadable] [unreadable]..
  35. Vcsa1 (hSMR3A) as a Marker for Diabetes
    Kelvin Davies; Fiscal Year: 2008
    ..The final aim will be to determine expression levels of hSMR3A protein from diabetic and non-diabetic patients (in saliva, blood and corporal samples) as an indicator of vascular health. [unreadable] [unreadable] [unreadable]..
  36. Advancing Islet Transplants for Type 1 Diabetes Care
    Bernhard Hering; Fiscal Year: 2008
    ..This study will also provide a rational basis for treatment recommendations for type 1 diabetic patients with early microvascular lesions. ..
  37. High Gulcose Promotes Myocyte Apoptosis by PKC Pathways
    Ashwani Malhotra; Fiscal Year: 2008
    ..The proposed investigations are novel and fundamental to the development of gene based therapy to inhibit myocyte apoptosis in the diabetic heart. ..
  38. Multifunctional Antioxidants as Anti-Cataract Agents
    Peter Kador; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  39. ENDOTHELIN EFFECTS ON RETINAL CELLS AND BLOOD FLOW
    George King; Fiscal Year: 2001
    ....
  40. CELL BIOLOGY APPROACH TO DIABETIC RETINOPATHY
    George King; Fiscal Year: 2001
    ..The results from the use of LY333531 and the transgenic mice models will provide direct evidence to determine the roles of PKC beta isoform activation in the development of vascular complications of diabetes. ..
  41. VASCULAR GRAFT ATHEROSCLEROSIS
    Yi Shi; Fiscal Year: 2001
    ..Thus this proposal examines putative mechanisms responsible for graft attrition in relation to cellular heterogeneity of the vessel. ..
  42. Effect of Diabetes on Bone Integration of Implants
    Michael McCracken; Fiscal Year: 2002
    ..This knowledge may lead to bioengineered materials which will modify and improve bone healing response in diabetic patients who receive implants. ..
  43. Gene therapy for bladder hyperactivity in diabetic rats
    George Christ; Fiscal Year: 2002
    ..In year 2 of this proposal we will study the prophylactic ability and duration of this gene therapy approach. ..
  44. VARIOUS PAIN STATES ON OPIOID TRANSPORT ACROSS THE BBB
    Jason Huber; Fiscal Year: 2003
    ..Ultimately, this grant may identify a pharmacological approach that could be used in conjunction with current therapies to alleviate pain with greater efficacy and fewer adverse side effects. ..
  45. DYNAMIC FEEDBACK CONTROL OF THE GH AXIS
    LEON FARHI; Fiscal Year: 2004
    ..abstract_text> ..
  46. PATHOGENESIS OF AUTOIMMUNE DIABETES IN MICE
    Edward Leiter; Fiscal Year: 2004
    ..Understanding the contributions of diabetes modifying genes in the extended mouse MIHC may identify human HLA orthologs whose presence has recently been established. ..
  47. PROTEIN KINASE C ACTIVATION AND DIABETIC CARDIOMYOPATHY
    George King; Fiscal Year: 2004
    ..3) Characterize the molecular and functional differences in the myocardium of transgenic mice overexpression PKCB2 and delta isoform in diabetic and non-diabetic states. ..
  48. Gene Therapy of Muscle Wasting From Uremia
    Xiaonan Wang; Fiscal Year: 2005
    ..We believe that the experimental results will shed the insight on the mechanisms of muscle protein degradation, and provide a possible new approach to treat the pathological process of muscle wasting. ..
  49. Hyperglycemia, Aldose Reducatse & Murine Atherosclerosis
    Ira Goldberg; Fiscal Year: 2005
    ..This is significant because it will provide for a model to study this complication and suggest a therapeutic target for prevention of diabetic macrovascular disease. ..
  50. Near Infra Red Energy To Treat Diabetic Neuropathy
    NIGEL CALCUTT; Fiscal Year: 2006
    ..abstract_text> ..
  51. POLYOL PATHWAY AND ISCHEMIC INJURY IN DIABETIC HEARTS
    Ravichandran Ramasamy; Fiscal Year: 2005
    ..The proposed studies will provide a rationale for the use of polyol pathway inhibitors as an adjunctive therapeutic intervention for treating diabetic patients with myocardial infarction. ..
  52. ANGIOTENSIN ANALOGS TO TREAT WOUND HEALING
    Kathleen Rodgers; Fiscal Year: 2005
    ..In this phase II SBIR, these compounds will undergo extensive preclinical testing to determine whether they should be further developed as a second generation of wound healing drugs. ..
  53. REGULATION OF TRANSCRIPTION BY THE RB ANTIONCOGENE
    Paul Robbins; Fiscal Year: 2002
    ..The experiments described in the proposal are expected to provide important insights into the mechanism of how RB and cyclin D1 function to regulate transcription directly, cell differentiation, and tumorigenesis. ..
  54. 2008 Viral Vectors for Gene Therapy, The Science of Gordon Research Conference
    Paul Robbins; Fiscal Year: 2008
    ..End of Abstract) [unreadable] [unreadable] [unreadable]..
  55. Agmatine Mediated Arrest of Proliferation
    Joseph Satriano; Fiscal Year: 2003
    ..UCSD has established itself as a leading academic institution and thus provides an excellent environment for the exchange of ideas and techniques essential for the growth of the PI's career. ..
  56. Progenitor Cell Dysfunction and Impaired Vasculogenesis*
    Michael Brownlee; Fiscal Year: 2008
    ..rational development of novel strategies to restore normal compensatory vasculogenesis in diabetes, thus preventing the poor outcome of cardiovascular events (Ml, stroke, amputation) associated with the disease [unreadable] [unreadable]..
  57. The Angiotensin II-Induced JAK/STAT Pathway in Diabetes.
    Mario Marrero; Fiscal Year: 2005
    ..This area of research will provide new strategies and the potential for new therapeutics agents in the flight against diabetic complications. ..
  58. Diabetes Mellitus and Astrocyte Regulation of Glutamate
    Elaine Coleman; Fiscal Year: 2005
    ..In summary, this application targets the role of altered astrocyte activity and glutamate uptake in diabetes-induced CNS disorders. ..
  59. RAGE and a Novel Tumor Axis
    Ann Schmidt; Fiscal Year: 2005
    ....