diabetes complications

Summary

Summary: Conditions or pathological processes associated with the disease of diabetes mellitus. Due to the impaired control of BLOOD GLUCOSE level in diabetic patients, pathological processes develop in numerous tissues and organs including the EYE, the KIDNEY, the BLOOD VESSELS, and the NERVE TISSUE.

Top Publications

  1. ncbi Biochemistry and molecular cell biology of diabetic complications
    M Brownlee
    Department of Medicine, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York, 10461, USA
    Nature 414:813-20. 2001
  2. ncbi The prevalence of comorbid depression in adults with diabetes: a meta-analysis
    R J Anderson
    Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA
    Diabetes Care 24:1069-78. 2001
  3. ncbi Diabetic cardiomyopathy revisited
    Sihem Boudina
    Division of Endocrinology, Metabolism and Diabetes and Program in Human Molecular Biology and Genetics, University of Utah School of Medicine, Salt Lake City 84112, USA
    Circulation 115:3213-23. 2007
  4. pmc Diabetes mellitus increases the risk of active tuberculosis: a systematic review of 13 observational studies
    Christie Y Jeon
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS Med 5:e152. 2008
  5. ncbi Diabetes mellitus as a predictor of cancer mortality in a large cohort of US adults
    Steven S Coughlin
    Epidemiology and Applied Research Branch, Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Am J Epidemiol 159:1160-7. 2004
  6. ncbi Risk of dementia in diabetes mellitus: a systematic review
    Geert Jan Biessels
    Department of Neurology, Rudolf Magnus Institute of Neurosciences, University Medical Center Utrecht, Netherlands
    Lancet Neurol 5:64-74. 2006
  7. ncbi Diabetes in sub-Saharan Africa
    Jean Claude N Mbanya
    Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon
    Lancet 375:2254-66. 2010
  8. ncbi Fasting serum glucose level and cancer risk in Korean men and women
    Sun Ha Jee
    Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea
    JAMA 293:194-202. 2005
  9. ncbi Diabetes mellitus and risk of colorectal cancer: a meta-analysis
    Susanna C Larsson
    Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    J Natl Cancer Inst 97:1679-87. 2005
  10. pmc The impact of diabetes on tuberculosis treatment outcomes: a systematic review
    Meghan A Baker
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    BMC Med 9:81. 2011

Detail Information

Publications327 found, 100 shown here

  1. ncbi Biochemistry and molecular cell biology of diabetic complications
    M Brownlee
    Department of Medicine, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York, 10461, USA
    Nature 414:813-20. 2001
    ..This integrating paradigm provides a new conceptual framework for future research and drug discovery...
  2. ncbi The prevalence of comorbid depression in adults with diabetes: a meta-analysis
    R J Anderson
    Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA
    Diabetes Care 24:1069-78. 2001
    ..CONCLUSIONS--The presence of diabetes doubles the odds of comorbid depression. Prevalence estimates are affected by several clinical and methodological variables that do not affect the stability of the ORs...
  3. ncbi Diabetic cardiomyopathy revisited
    Sihem Boudina
    Division of Endocrinology, Metabolism and Diabetes and Program in Human Molecular Biology and Genetics, University of Utah School of Medicine, Salt Lake City 84112, USA
    Circulation 115:3213-23. 2007
    ..This review discusses the latest findings in diabetic humans and in animal models and reviews emerging new mechanisms that may be involved in the development and progression of cardiac dysfunction in diabetes...
  4. pmc Diabetes mellitus increases the risk of active tuberculosis: a systematic review of 13 observational studies
    Christie Y Jeon
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS Med 5:e152. 2008
    ..We conducted a systematic review and a meta-analysis of observational studies assessing the association of DM and TB in order to summarize the existing evidence and to assess methodological quality of the studies...
  5. ncbi Diabetes mellitus as a predictor of cancer mortality in a large cohort of US adults
    Steven S Coughlin
    Epidemiology and Applied Research Branch, Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Am J Epidemiol 159:1160-7. 2004
    ..11, 1.45). These associations were not explained by high body mass. Our findings suggest that diabetes is an independent predictor of mortality from cancer of the colon, pancreas, female breast, and, in men, of the liver and bladder...
  6. ncbi Risk of dementia in diabetes mellitus: a systematic review
    Geert Jan Biessels
    Department of Neurology, Rudolf Magnus Institute of Neurosciences, University Medical Center Utrecht, Netherlands
    Lancet Neurol 5:64-74. 2006
    ..Further high quality studies need to be initiated, with objective diabetes assessment, together with reliable methods to establish the contribution of vascular disease and other comorbidity to dementia...
  7. ncbi Diabetes in sub-Saharan Africa
    Jean Claude N Mbanya
    Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon
    Lancet 375:2254-66. 2010
    ..A multisectoral approach to diabetes control and care is vital for expansion of socioculturally appropriate diabetes programmes in sub-Saharan African countries...
  8. ncbi Fasting serum glucose level and cancer risk in Korean men and women
    Sun Ha Jee
    Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea
    JAMA 293:194-202. 2005
    ..Diabetes is a serious and costly disease that is becoming increasingly common in many countries. The role of diabetes as a cancer risk factor remains unclear...
  9. ncbi Diabetes mellitus and risk of colorectal cancer: a meta-analysis
    Susanna C Larsson
    Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    J Natl Cancer Inst 97:1679-87. 2005
    ..To resolve these inconsistencies, we conducted a meta-analysis of published data on the association between diabetes and the incidence and mortality of colorectal cancer...
  10. pmc The impact of diabetes on tuberculosis treatment outcomes: a systematic review
    Meghan A Baker
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    BMC Med 9:81. 2011
    ..We performed a systematic review and meta-analysis to quantitatively summarize evidence for the impact of diabetes on tuberculosis outcomes...
  11. pmc Risk of malignancies in patients with diabetes treated with human insulin or insulin analogues: a cohort study
    L G Hemkens
    Institute for Quality and Efficiency in Health Care IQWiG, Dillenburger Strasse 27, D 51105, Cologne, Germany
    Diabetologia 52:1732-44. 2009
    ..The aim of this cohort study was to investigate the risk of malignant neoplasms and mortality in patients with diabetes treated either with human insulin or with one of three insulin analogues...
  12. ncbi Ethnic disparities in diabetic complications in an insured population
    Andrew J Karter
    Division of Research, Kaiser Permanente, 2000 Broadway, Oakland, CA 94612, USA
    JAMA 287:2519-27. 2002
    ..Disparate access to quality health care is a common explanation for ethnic disparities in diabetic complication rates in the US population. Examining an ethnically diverse population with uniform health care coverage may be useful...
  13. ncbi Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators
    S Yusuf
    Canadian Cardiovascular Collaboration Project Office, Hamilton General Hospital, McMaster University, ON
    N Engl J Med 342:145-53. 2000
    ..We assessed the role of an angiotensin-converting-enzyme inhibitor, ramipril, in patients who were at high risk for cardiovascular events but who did not have left ventricular dysfunction or heart failure...
  14. pmc Tuberculosis and diabetes mellitus: convergence of two epidemics
    Kelly E Dooley
    Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Lancet Infect Dis 9:737-46. 2009
    ..In addition, we review potential mechanisms by which diabetes mellitus can cause tuberculosis, the effects of tuberculosis on diabetic control, and pharmacokinetic issues related to the co-management of diabetes and tuberculosis...
  15. ncbi Diabetic cardiovascular autonomic neuropathy
    Aaron I Vinik
    Strelitz Diabetes Research Institute, 855 W Brambleton Avenue, Norfolk, VA 23510, USA
    Circulation 115:387-97. 2007
  16. ncbi Progressive attenuation of myocardial vascular endothelial growth factor expression is a seminal event in diabetic cardiomyopathy: restoration of microvascular homeostasis and recovery of cardiac function in diabetic cardiomyopathy after replenishment of
    Young Sup Yoon
    Division of Cardiovascular Research, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Mass 02135, USA
    Circulation 111:2073-85. 2005
    ..Diabetic cardiomyopathy (DCM) is characterized by microvascular pathology and interstitial fibrosis, which leads to progressive heart failure; however, the pathogenesis of DCM remains uncertain...
  17. ncbi Diabetes mellitus and the risk of cancer: results from a large-scale population-based cohort study in Japan
    Manami Inoue
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Arch Intern Med 166:1871-7. 2006
    ..An association between diabetes mellitus (DM) and cancer has long been speculated, but no conclusive evidence has been obtained...
  18. ncbi Relationship of depression and diabetes self-care, medication adherence, and preventive care
    Elizabeth H B Lin
    Center for Health Studies, Group Health Cooperative, 1730 Minor Ave, Suite 1600, Seattle, WA 98101, USA
    Diabetes Care 27:2154-60. 2004
    ..We assessed whether diabetes self-care, medication adherence, and use of preventive services were associated with depressive illness...
  19. ncbi AHA/ACC guidelines for secondary prevention for patients with coronary and other atherosclerotic vascular disease: 2006 update: endorsed by the National Heart, Lung, and Blood Institute
    Sidney C Smith
    Circulation 113:2363-72. 2006
  20. ncbi Diabetic cardiomyopathy: insights into pathogenesis, diagnostic challenges, and therapeutic options
    Ashish Aneja
    The Mount Sinai Cardiovascular Institute, New York, NY 10029, USA
    Am J Med 121:748-57. 2008
    ..Although glycemic control and early administration of neurohormonal antagonists remain the cornerstones of therapeutic approaches, newer treatment targets are currently being explored...
  21. ncbi Diabetes and pancreatic cancer: chicken or egg?
    J Trent Magruder
    Department of Surgery, Johns Hopkins University School of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, MD, USA
    Pancreas 40:339-51. 2011
    ..Although half of all patients with pancreatic cancer are diabetic at the time of diagnosis, it remains unclear whether the diabetes associated with pancreatic cancer is a cause or an effect of the malignancy...
  22. ncbi Clinical review: The role of advanced glycation end products in progression and complications of diabetes
    Su Yen Goh
    Albert Einstein Juvenile Diabetes Research Foundation, Centre for Diabetes Complications, Diabetes and Metabolism Division, Baker Medical Research Institute, Melbourne, Victoria, Australia 8008
    J Clin Endocrinol Metab 93:1143-52. 2008
    ....
  23. ncbi The role of vitamin E and oxidative stress in diabetes complications
    Robert Pazdro
    Department of Foods and Nutrition, Purdue University, 700 West State Street, West Lafayette, IN 47907, USA
    Mech Ageing Dev 131:276-86. 2010
    ..More studies are required to make definitive conclusions about the effect of vitamin E treatment on diabetes complications in human subjects.
  24. ncbi Advanced glycation endproducts--role in pathology of diabetic complications
    Nessar Ahmed
    Biomedical Science Research Group, Department of Biological Sciences, Manchester Metropolitan University, Chester Street, Manchester M1 5GD, UK
    Diabetes Res Clin Pract 67:3-21. 2005
    ..The mechanisms and sites of action of selected inhibitors, together with their potential in preventing diabetic complications are discussed...
  25. ncbi The molecular biology of chronic wounds and delayed healing in diabetes
    R Blakytny
    Fachklinik Hornheide, Tumor Forschung, Munster, Germany
    Diabet Med 23:594-608. 2006
    ..This review examines the work done at the molecular level on chronic diabetic ulcers, as well as considering changes seen in diabetes in general, both in humans and animal models, that may in turn contribute to ulcer formation...
  26. ncbi Albuminuria and risk of cardiovascular events, death, and heart failure in diabetic and nondiabetic individuals
    H C Gerstein
    Department of Medicine, Room 3V38, 1200 Main St W, Hamilton, Ontario, L8N 3Z5
    JAMA 286:421-6. 2001
    ..Microalbuminuria is a risk factor for cardiovascular (CV) events. The relationship between the degree of albuminuria and CV risk is unclear...
  27. pmc Diabetes, glycemic control, and risk of hospitalization with pneumonia: a population-based case-control study
    Jette B Kornum
    Department of Clinical Epidemiology, Aarhus University Hospital, Aalborg, Denmark
    Diabetes Care 31:1541-5. 2008
    ..To examine whether diabetes is a risk factor for hospitalization with pneumonia and to assess the impact of A1C level on such risk...
  28. ncbi The global burden of diabetes and its complications: an emerging pandemic
    Susan van Dieren
    Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands
    Eur J Cardiovasc Prev Rehabil 17:S3-8. 2010
    ..Global excess mortality attributable to diabetes in adults was estimated to be 3.8 million deaths...
  29. ncbi Diabetes mellitus and risk of bladder cancer: a meta-analysis
    S C Larsson
    Division of Nutritional Epidemiology, National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Diabetologia 49:2819-23. 2006
    ..We performed a systematic review with meta-analysis to evaluate the association between diabetes and risk of bladder cancer...
  30. pmc A global emerging disease of Klebsiella pneumoniae liver abscess: is serotype K1 an important factor for complicated endophthalmitis?
    C P Fung
    Section of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital and National Yang Ming University, Taipei, Taiwan
    Gut 50:420-4. 2002
    ..However, the relationship between the clinical presentation and bacterial factors remains unclear. The aim of this study was to investigate the clinical features of patients and the serotype and ribotype of K pneumoniae liver abscess...
  31. ncbi Impact of diabetes mellitus on outcomes in patients with colon cancer
    Jeffrey A Meyerhardt
    Dana Farber Cancer Institute, Eastern Cooperative Oncology Group Statistical Center, and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Clin Oncol 21:433-40. 2003
    ..To determine the influence of diabetes mellitus on long-term outcomes and treatment-related toxicity among patients with curatively resected colon cancer...
  32. ncbi Mortality trends in men and women with diabetes, 1971 to 2000
    Edward W Gregg
    National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30341 3727, USA
    Ann Intern Med 147:149-55. 2007
    ..Whether mortality rates among diabetic adults or excess mortality associated with diabetes in the United States has declined in recent decades is not known...
  33. ncbi Glucose variability; does it matter?
    Sarah E Siegelaar
    Academic Medical Center, Department of Internal Medicine, Meibergdreef 9, Room F4 255, 1105 AZ Amsterdam, The Netherlands
    Endocr Rev 31:171-82. 2010
    ....
  34. ncbi Diabetes mellitus and periodontal diseases
    Brian L Mealey
    Department of Periodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    J Periodontol 77:1289-303. 2006
    ....
  35. pmc miR-146a-Mediated extracellular matrix protein production in chronic diabetes complications
    Biao Feng
    Department of Pathology, Schulich School of Medicine and Dentistry and the University of Western Ontario, London, Ontario, Canada
    Diabetes 60:2975-84. 2011
    ..Here, we investigated the role of miR-146a, an FN-targeting miRNA, on FN production in diabetes and its relationship with p300...
  36. ncbi Periodontal disease: associations with diabetes, glycemic control and complications
    G W Taylor
    School of Dentistry, University of Michigan, Ann Arbor, MI 48109, USA
    Oral Dis 14:191-203. 2008
    ..This report reviews the evidence for adverse effects of diabetes on periodontal health and periodontal disease on glycemic control and complications of diabetes...
  37. ncbi Mechanisms of disease: advanced glycation end-products and their receptor in inflammation and diabetes complications
    Shi Fang Yan
    Division of Surgical Science, Department of Surgery, Columbia University Medical Center, New York, NY 10032, USA
    Nat Clin Pract Endocrinol Metab 4:285-93. 2008
    ....
  38. ncbi Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001
    Ali H Mokdad
    Division of Adult and Community Health, 4770 National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341 3717, USA
    JAMA 289:76-9. 2003
    ..Obesity and diabetes are increasing in the United States...
  39. ncbi Risk of hepatocellular carcinoma in diabetic patients and risk reduction associated with anti-diabetic therapy: a population-based cohort study
    Shih Wei Lai
    Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan
    Am J Gastroenterol 107:46-52. 2012
    ..Using population-based representative insurance claims data, the risk of developing hepatocellular carcinoma (HCC) among diabetes mellitus (DM) patients, as well as whether DM medications alter the risk of developing HCC were investigated...
  40. ncbi Diabetes mellitus and risk of endometrial cancer: a meta-analysis
    E Friberg
    Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, PO Box 210, 171 77, Stockholm, Sweden
    Diabetologia 50:1365-74. 2007
    ..To provide a quantitative assessment of the association between diabetes and risk of endometrial cancer, we conducted a meta-analysis of case-control studies and cohort studies...
  41. pmc Diabetic cardiomyopathy: from the pathophysiology of the cardiac myocytes to current diagnosis and management strategies
    Christina Voulgari
    First Department of Propaedeutic and Internal Medicine, Athens University Medical School, Laiko General Hospital, Athens, Greece
    Vasc Health Risk Manag 6:883-903. 2010
    ..Its pathophysiological substrate is also the objective for the new therapies and alternative remedies...
  42. pmc Prevalence and management of diabetes in Korean adults: Korea National Health and Nutrition Examination Surveys 1998-2005
    Yong Jun Choi
    Department of Internal Medicine, the Armed Forces Capital Hospital, Sungnam, Republic of Korea
    Diabetes Care 32:2016-20. 2009
    ..This research investigated recent changes in the prevalence and management status of diabetes among Korean adults...
  43. ncbi Insulin and neurodegenerative disease: shared and specific mechanisms
    Suzanne Craft
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Medical Center, Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, 98108, USA
    Lancet Neurol 3:169-78. 2004
    ..We conclude by considering whether insulin dysregulation contributes to neurodegenerative disorders through disease-specific or general mechanisms...
  44. pmc Risk of cancer in a large cohort of U.S. veterans with diabetes
    Elizabeth A Atchison
    Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, MD, USA
    Int J Cancer 128:635-43. 2011
    ..Hyperinsulinemia may explain the increased risks of the digestive cancers, while lower testosterone levels, in the case of prostate cancer, and higher BMI, in the case of lung cancer, may explain the decreased risks of those tumors...
  45. ncbi The effect of type 2 diabetes mellitus on the presentation and treatment response of pulmonary tuberculosis
    Bachti Alisjahbana
    Internal Medicine, Medical Faculty, Padjadjaran University, Bandung, Indonesia
    Clin Infect Dis 45:428-35. 2007
    ..Presently, little is known about the effect of DM on the clinical presentation and treatment outcome of TB...
  46. pmc NH2-terminal probrain natriuretic peptide is associated with diabetes complications in the EURODIAB Prospective Complications Study: the role of tumor necrosis factor-α
    Gabriella Gruden
    Department of Internal Medicine, University of Turin, Turin, Italy
    Diabetes Care 35:1931-6. 2012
    ..We investigated whether serum NT-proBNP levels were associated with micro- and macrovascular disease in type 1 diabetic subjects...
  47. ncbi The effects of diabetes on the risks of major cardiovascular diseases and death in the Asia-Pacific region
    M Woodward
    Diabetes Care 26:360-6. 2003
    ..To provide reliable age- and region-specific estimates of the associations between diabetes and major cardiovascular diseases and death in populations from the Asia-Pacific region...
  48. pmc Diabetes increases the risk of hepatocellular carcinoma in the United States: a population based case control study
    J A Davila
    Houston Veterans Affairs Medical Center, 2002 Holcombe Blvd 152, Houston, TX 77030, USA
    Gut 54:533-9. 2005
    ..This is the first population based case control study in the USA to examine this association while adjusting for other major risk factors related to HCC...
  49. ncbi Common infections in diabetes: pathogenesis, management and relationship to glycaemic control
    Anton Y Peleg
    Department of Infectious Diseases, Royal Brisbane and Women s Hospital, Herston, Brisbane, Australia
    Diabetes Metab Res Rev 23:3-13. 2007
    ..Nevertheless, further research is needed to improve our understanding of the role of diabetes and glycaemic control in the pathogenesis and management of community- and hospital-acquired infections...
  50. pmc Long-term lifestyle intervention lowers the incidence of stroke in Japanese patients with type 2 diabetes: a nationwide multicentre randomised controlled trial (the Japan Diabetes Complications Study)
    H Sone
    Department of Internal Medicine, University of Tsukuba Institute of Clinical Medicine, 1 1 1 Tennodai, Tsukuba, Ibaraki, Japan
    Diabetologia 53:419-28. 2010
    ..The aim of the study was to clarify whether a therapeutic intervention focused on lifestyle modification affected the incidence of vascular complications in patients with established diabetes...
  51. ncbi Markers of inflammation are cross-sectionally associated with microvascular complications and cardiovascular disease in type 1 diabetes--the EURODIAB Prospective Complications Study
    M T Schram
    Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Diabetologia 48:370-8. 2005
    ..The pathogenesis of vascular complications in type 1 diabetes is poorly understood, but may involve chronic, low-grade inflammation. We investigated the association of markers of inflammation with vascular complications in type 1 diabetes...
  52. ncbi Quantifying the risk of infectious diseases for people with diabetes
    Baiju R Shah
    Department of Medicine, University of Toronto, Canada
    Diabetes Care 26:510-3. 2003
    ..Although certain rare infections are more common and infection-related mortality is higher, the risk of acquiring an infectious disease for diabetic patients has never been quantified...
  53. ncbi Socio-economic inequalities in diabetes complications, control, attitudes and health service use: a cross-sectional study
    M O Bachmann
    Medical Research Council Health Services Research Collaboration, Department of Social Medicine, University of Bristol, Bristol, UK
    Diabet Med 20:921-9. 2003
    To investigate socio-economic inequalities in diabetes complications, and to examine factors that may explain these differences.
  54. ncbi Primary prevention of cardiovascular diseases in people with diabetes mellitus: a scientific statement from the American Heart Association and the American Diabetes Association
    John B Buse
    University of North Carolina, USA
    Circulation 115:114-26. 2007
    ..This statement will attempt to harmonize the recommendations of both organizations where possible but will recognize areas in which AHA and ADA recommendations differ...
  55. ncbi Diabetes mellitus is strongly associated with tuberculosis in Indonesia
    B Alisjahbana
    Department of Internal Medicine, Medical Faculty, Padjadjaran University, Bandung, Indonesia
    Int J Tuberc Lung Dis 10:696-700. 2006
    ..Diabetes mellitus is a known risk factor for tuberculosis (TB), but no studies have been reported from South-East Asia, which has a high burden of TB and a rapidly growing prevalence of diabetes...
  56. pmc Depression and quality of life in patients with diabetes: a systematic review from the European depression in diabetes (EDID) research consortium
    Miranda T Schram
    National Institute for Public Health and the Environment, Centre for Prevention and Health Services Research, Bilthoven, The Netherlands
    Curr Diabetes Rev 5:112-9. 2009
    ..Generic and domain specific quality of life were found to be mild to moderately lower in the presence of depressive symptoms. Therefore, increased awareness and monitoring for depression is needed within different diabetes care settings...
  57. ncbi Effects of treatment for diabetes mellitus on circulating vascular progenitor cells
    Takanori Kusuyama
    Department of Internal Medicine and Cardiology, Osaka City University Medical School, Japan
    J Pharmacol Sci 102:96-102. 2006
    ..DM reduces the number of circulating EPCs and SMPCs according to its severity, and treatment of DM significantly increases the number of EPCs and SMPCs, which may be involved in angiogenesis and atherosclerosis in diabetes...
  58. ncbi The association of diabetes mellitus with liver, colon, lung, and prostate cancer is independent of hypertension, hyperlipidemia, and gout in Taiwanese patients
    Mei Yueh Lee
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    Metabolism 61:242-9. 2012
    ..The most common cancers were liver, colon, lung, breast, and prostate cancer; and except for breast cancer, their incidences increased independently of hypertension, dyslipidemia, and gout in patients with diabetes...
  59. ncbi Influence of diabetes on manifestations and treatment outcome of pulmonary TB patients
    R Singla
    Department of Tuberculosis and Chest Diseases, Lala Ram Sarup Institute of Tuberculosis and Respiratory Diseases, Sri Aurobindo Marg, New Delhi, India
    Int J Tuberc Lung Dis 10:74-9. 2006
    ..To understand the influence of diabetes on the clinical and bacteriological aspects and treatment outcome of pulmonary tuberculosis (PTB) patients...
  60. ncbi Effect of postprandial hypertriglyceridemia and hyperglycemia on circulating adhesion molecules and oxidative stress generation and the possible role of simvastatin treatment
    Antoniom Ceriello
    Department of Pathology and Medicine, Experimental and Clinical, University of Udine, Udine, Italy
    Diabetes 53:701-10. 2004
    ..Simvastatin shows a beneficial effect on oxidative stress and the plasma levels of adhesion molecules, which may be ascribed to a direct effect in addition to the lipid-lowering action of the drug...
  61. ncbi Angiotensin receptor blockade and risk of cancer in type 2 diabetes mellitus: a nationwide case-control study
    Chia Hsuin Chang
    Institute of Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan
    J Clin Oncol 29:3001-7. 2011
    ..The objective of this case-control study was to evaluate the risk of malignancy in diabetic patients who received angiotensin receptor blockers (ARBs)...
  62. pmc Diabetes complications severity index and risk of mortality, hospitalization, and healthcare utilization
    Bessie Ann Young
    Veterans Affairs Puget Sound Health Care System 152 E, Epidemiologic Research and Information Center, Seattle, WA 98108, USA
    Am J Manag Care 14:15-23. 2008
    To determine whether the number and severity of diabetes complications are associated with increased risk of mortality and hospitalizations.
  63. pmc Pyogenic liver abscess as endemic disease, Taiwan
    Feng Chiao Tsai
    National Taiwan University Hospital, Taipei, Taiwan
    Emerg Infect Dis 14:1592-600. 2008
    ..Diabetes did not significantly change death rates for the 506 patients from the hospital...
  64. ncbi Estimating the burden of disease attributable to diabetes in South Africa in 2000
    Debbie Bradshaw
    Burden of Disease Research Unit, South African Medical Research Council, Tygerberg, Cape Town
    S Afr Med J 97:700-6. 2007
    ..To estimate the burden of disease attributable to diabetes by sex and age group in South Africa in 2000...
  65. ncbi Impaired autonomic function is associated with increased mortality, especially in subjects with diabetes, hypertension, or a history of cardiovascular disease: the Hoorn Study
    J Gerritsen
    Department of Clinical Physics and Informatics, Vrije Universiteit, Amsterdam, The Netherlands
    Diabetes Care 24:1793-8. 2001
    ..Moreover, the results of the present study suggest that cardiac autonomic dysfunction in patients already at risk (diabetes, hypertension, or history of cardiovascular disease) may be especially hazardous...
  66. pmc The impact of diabetes on the pathogenesis of sepsis
    G C K W Koh
    The Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK
    Eur J Clin Microbiol Infect Dis 31:379-88. 2012
    ..In addition, the effect of diabetes treatment on the immune response is discussed, with specific reference to insulin, metformin, sulphonylureas and thiazolidinediones...
  67. pmc Associations between socioeconomic status and major complications in type 1 diabetes: the Pittsburgh epidemiology of diabetes complication (EDC) Study
    Aaron M Secrest
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Ann Epidemiol 21:374-81. 2011
    To understand the effect of socioeconomic status (SES) on the risk of complications in type 1 diabetes (T1D), we explored the relationship between SES and major diabetes complications in a prospective, observational T1D cohort study.
  68. ncbi Impact of diabetes mellitus on recurrence and progression in patients with non-muscle invasive bladder carcinoma: a retrospective cohort study
    Eu Chang Hwang
    Department of Urology, Chonnam National University Medical School, Gwangju, Korea
    Int J Urol 18:769-76. 2011
    ..The aim of the present study was to investigate the relationship between diabetes mellitus (DM) and tumor features in patients with non-muscle invasive bladder cancer (NMIBC)...
  69. pmc Considering hyperglycemia and thrombolysis in the Stroke Hyperglycemia Insulin Network Effort (SHINE) trial
    Andrew M Southerland
    Division of Vascular Neurology, Department of Neurology, University of Virginia Health System, Charlottesville, Virginia, USA
    Ann N Y Acad Sci 1268:72-8. 2012
    ..With enrollment recently underway, the stratified results from the SHINE trial could substantially influence future treatment decisions for hyperglycemic stroke patients...
  70. ncbi The costs of type 2 diabetes mellitus outpatient care in the Brazilian public health system
    Luciana R Bahia
    Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil
    Value Health 14:S137-40. 2011
    ..The objective of the Brazilian Study on Diabetes Costs (ESCUDI study) was to estimate direct and indirect costs of type 2 diabetes outpatient care in the Brazilian Public Health Care System...
  71. ncbi Guidelines for improving the care of the older person with diabetes mellitus
    Arlene F Brown
    J Am Geriatr Soc 51:S265-80. 2003
  72. pmc Diabetes mellitus, glycemic control, and risk of atrial fibrillation
    Sascha Dublin
    Group Health Research Institute, 1730 Minor Avenue, Suite 1600, Seattle, WA 98101 1448, USA
    J Gen Intern Med 25:853-8. 2010
    ..Diabetes may be an independent risk factor for atrial fibrillation. However, results from prior studies are in conflict, and no study has examined diabetes duration or glycemic control...
  73. pmc Impact of diabetes mellitus on complications and outcomes of adjuvant chemotherapy in older patients with breast cancer
    Tomasz P Srokowski
    Division of Cancer Medicine, and Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    J Clin Oncol 27:2170-6. 2009
    ..To evaluate whether diabetes affects patterns of adjuvant chemotherapy use, toxic effects of chemotherapy, and breast cancer outcomes...
  74. ncbi Diabetes mellitus and increased risk of biliary tract cancer: systematic review and meta-analysis
    Hong Bo Ren
    Department of Gastroenterology, Shandong University Qilu Hospital, Jinan, China
    Cancer Causes Control 22:837-47. 2011
    ..Epidemiological evidences indicate that diabetic individuals may have an increased risk of several cancers; however, the relationships between diabetes and risk of cancers of biliary tract or its subsites remain unclear...
  75. ncbi The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation provides a better definition of cardiovascular burden associated with CKD than the Modification of Diet in Renal Disease (MDRD) Study formula in subjects with type 2 diabetes
    Giuseppe Pugliese
    Department of Clinical and Molecular Medicine, La Sapienza University, Rome, Italy
    Atherosclerosis 218:194-9. 2011
    ..This study was aimed at assessing cardiovascular disease (CVD) burden associated with CKD in type 2 diabetes, using these two GFR estimating formulas for CKD definition...
  76. pmc Mitochondrial DNA backgrounds might modulate diabetes complications rather than T2DM as a whole
    Alessandro Achilli
    Dipartimento di Biologia Cellulare e Ambientale, Universita di Perugia, Perugia, Italy
    PLoS ONE 6:e21029. 2011
    ..Effects of mtDNA variation on diabetes complications have also been proposed...
  77. ncbi Incidences of cancers in diabetic and non-diabetic hospitalized adult patients in Taiwan
    Wen Ko Chiou
    Department of Industrial Design, Healthy Aging Research Center, Chang Gung University, and Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan Hsien, Taiwan
    Asian Pac J Cancer Prev 12:1577-81. 2011
    ..The study was to investigate the relationship between diabetes mellitus ( DM), specific cancers, age, and gender...
  78. ncbi Interleukin-6 in the prediction of primary cardiovascular events in diabetes patients: results from the ESTHER study
    Christian Herder
    Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    Atherosclerosis 216:244-7. 2011
    ..Thus, we investigated whether IL-6 is associated with incident primary cardiovascular events and improves risk prediction in diabetes patients...
  79. pmc Early diagnosis of left ventricular diastolic dysfunction in diabetic patients: a possible role for natriuretic peptides
    Silvio Romano
    Cardiology, Department of Internal Medicine and Public Health, University of L Aquila, Italy
    Cardiovasc Diabetol 9:89. 2010
    ..The aim of the present study was to verify whether BNP might detect pre-clinical diastolic dysfunction (LVDD) in type-2 diabetic patients...
  80. pmc Tempering the wrath of RAGE: an emerging therapeutic strategy against diabetic complications, neurodegeneration, and inflammation
    Shi Fang Yan
    Division of Surgical Science, Department of Surgery, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Ann Med 41:408-22. 2009
    ..As RAGE blockade moves further into clinical development, clarifying the biology of RAGE garners ever-increasing importance...
  81. ncbi Bi-directional screening for tuberculosis and diabetes: a systematic review
    Christie Y Jeon
    Department of Epidemiology, Harvard School of Public Health, 641 Huntington Avenue, Boston, MA 02115, USA
    Trop Med Int Health 15:1300-14. 2010
    ..To assess the yield of finding additional TB or diabetes mellitus (DM) cases through systematic screening and to determine the effectiveness of preventive TB therapy in people with DM...
  82. ncbi Diabetic dyslipidaemia: from basic research to clinical practice
    M R Taskinen
    Department of Medicine, Division of Cardiology, University of Helsinki, Helsinki, Finland
    Diabetologia 46:733-49. 2003
    ..These observations suggest these factors as a new target to tailor more efficient drugs to treat diabetic dyslipidaemia...
  83. pmc Recurrent Klebsiella pneumoniae liver abscess: clinical and microbiological characteristics
    Ya Sung Yang
    Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, R O C
    J Clin Microbiol 47:3336-9. 2009
    ..Most of the patients had diabetes and K1 serotype KLAs. All of the isolates were uniformly susceptible to cefazolin. Distinct molecular fingerprints were found for the strains isolated from both primary and recurrent KLAs...
  84. ncbi Effect of glycaemic control on apoptosis in diabetic wounds
    N K Rai
    Department of General Medicine, Institute of Medical Sciences, Banaras Hindu University, India
    J Wound Care 14:277-81. 2005
    ..To study the effect of glycaemic control on apoptosis in chronic ulcers in diabetic patients and the differential roles of insulin and oral hypoglycaemic agents (OHAs)...
  85. pmc Rapid identification of myocardial infarction risk associated with diabetes medications using electronic medical records
    John S Brownstein
    Children s Hospital Informatics Program at the Harvard MIT Division of Health Sciences and Technology, Boston, Massachusetts, USA
    Diabetes Care 33:526-31. 2010
    ..Our use of usual care electronic data sources from a large hospital network represents an innovative approach to rapid safety signal detection that may enable more effective postmarketing drug surveillance...
  86. pmc Associations of diabetes mellitus with site-specific cancer mortality in the Asia-Pacific region
    E K K Lam
    Department of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, UK
    Ann Oncol 22:730-8. 2011
    ..Owing to the increasing prevalence of obesity and diabetes in Asia, and the paucity of studies, we examined the influence of raised blood glucose and diabetes on cancer mortality risk...
  87. pmc Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia
    Assam El-Osta
    Diabetes and Metabolism Division, Baker Epigenetics in Human Health and Disease, Baker IDI Heart and Diabetes Institute, Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia
    J Exp Med 205:2409-17. 2008
    ....
  88. ncbi Managing type 2 diabetes: going beyond glycemic control
    Mark W Stolar
    Northwestern University Medical School, Chicago, IL 60611, USA markstolar nwinternist com
    J Manag Care Pharm 14:s2-19. 2008
    ..Attainment of treatment goals is associated with a decreased risk of diabetes-related complications, costs, and health care utilization...
  89. ncbi Defining the research agenda to reduce the joint burden of disease from diabetes mellitus and tuberculosis
    Anthony D Harries
    International Union Against Tuberculosis and Lung Disease, Paris, France
    Trop Med Int Health 15:659-63. 2010
    ..Implementation of this research agenda will benefit the control of both diseases...
  90. ncbi Gender differences in risk factor control and treatment profile in diabetes: a study in 229 swedish primary health care centres
    Peter M Nilsson
    Department of Medicine, University Hospital, Malmo, Sweden
    Scand J Prim Health Care 22:27-31. 2004
    ..To measure the risk factors and treatment profile of diabetes patients treated in primary health care (PHC) in order to evaluate potential gender differences...
  91. ncbi Expression and activity of arginase isoenzymes during normal and diabetes-impaired skin repair
    Heiko Kämpfer
    Pharmazentrum Frankfurt, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    J Invest Dermatol 121:1544-51. 2003
    ....
  92. ncbi Progression of kidney dysfunction in the community-dwelling elderly
    B R Hemmelgarn
    Department of Medicine, Division of Nephrology, University of Calgary, Calgary, Alberta, Canada
    Kidney Int 69:2155-61. 2006
    ..Strategies aimed at slowing progression of kidney disease should consider underlying risk factors for progression and the negligible loss of kidney function that occurs in the majority of older adults...
  93. ncbi Cardiovascular risk in women with diabetes
    A A Rivellese
    Department of Clinical and Experimental Medicine, Federico II University of Naples, Napoli, Italy
    Nutr Metab Cardiovasc Dis 20:474-80. 2010
    ..To meet these needs gender specific guidelines and implementation measures may be in order...
  94. ncbi Diabetes conveys a higher risk of gastric cancer mortality despite an age-standardised decreasing trend in the general population in Taiwan
    Chin Hsiao Tseng
    Department of Internal Medicine, National Taiwan University Hospital, Taipei 100, Taiwan
    Gut 60:774-9. 2011
    ..The association between diabetes and gastric cancer has been rarely studied...
  95. ncbi Clinical characteristics of dengue and dengue hemorrhagic fever in a medical center of southern Taiwan during the 2002 epidemic
    Min Sheng Lee
    Division of Pediatric Infectious Disease, Department of Pediatrics, Kaohsiung Medical University Chung Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    J Microbiol Immunol Infect 39:121-9. 2006
    ..This study investigated the clinical manifestations and risk factors for dengue fever (DF) and dengue hemorrhagic fever (DHF) and disease severity during the 2002 outbreak in the Kaohsiung area...
  96. pmc Impact of diabetes mellitus on treatment outcomes of patients with active tuberculosis
    Kelly E Dooley
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Am J Trop Med Hyg 80:634-9. 2009
    ..51). In conclusion, DM was a risk factor for death in Maryland TB patients. There was a trend toward increased time to culture conversion; two-month culture conversion proportions, however, were similar...
  97. ncbi Cost of illness of adult diabetes mellitus underestimated if comorbidity is not considered
    A Norlund
    Swedish Council on Technology Assessment in Health Care, Stockholm, Sweden
    J Intern Med 250:57-65. 2001
    ..To determine costs of illness for adult diabetes mellitus (DM), including complications caused by DM...
  98. ncbi Infections in diabetes
    H M Calvet
    Division of Infectious Diseases, Charles Drew University of Medicine and Science, Los Angeles, California, USA
    Infect Dis Clin North Am 15:407-21, viii. 2001
    ..Some of these immune deficiencies are improved by tight glucose control. This article is a review of the immune deficiencies seen in diabetes and an overview of selected infections that are commonly or predominantly seen in diabetics...
  99. ncbi Prediction of mortality using measures of cardiac autonomic dysfunction in the diabetic and nondiabetic population: the MONICA/KORA Augsburg Cohort Study
    Dan Ziegler
    Institute for Clinical Diabetes Research, German Diabetes Center, Leibniz Institute at the Heinrich Heine University, Dusseldorf, Germany
    Diabetes Care 31:556-61. 2008
    ..To evaluate whether reduced heart rate variability (HRV), prolonged corrected QT (QTc) interval, or increased QT dispersion (QTD) are predictors of mortality in the general diabetic and nondiabetic population...
  100. pmc Patient awareness of chronic kidney disease: trends and predictors
    Laura C Plantinga
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Arch Intern Med 168:2268-75. 2008
    ..The impact of recent guidelines for early detection and prevention of chronic kidney disease (CKD) on patient awareness of disease and factors that might be associated with awareness have not been well described...
  101. ncbi Impact of the metabolic syndrome on mortality from coronary heart disease, cardiovascular disease, and all causes in United States adults
    Shaista Malik
    Heart Disease Prevention Program, University of California, Irvine 92697, USA
    Circulation 110:1245-50. 2004
    ..We examined the impact of MetS on CHD, CVD, and overall mortality among US adults...

Research Grants62

  1. Na+/H+-exchanger-1 and Diabetic Neuropathy
    MARK ANTHONY YOREK; Fiscal Year: 2012
    ..Up regulation of Na? exchanger-1 (NHE-1), previously demonstrated in several tissue-sites for diabetes complications, causes an increase in cytosolic ph and related activation of the upper part of glycolysis...
  2. North Lawndale Diabetes Community Action Project
    STEVEN contact WHITMAN; Fiscal Year: 2010
    ..by a within-subject comparison of HbA1C, a marker of blood glucose control and demonstrated predictor of diabetes complications and mortality, between baseline and 2 follow-up testing periods...
  3. STATINS AND ACE INHIBITORS IN ADULTS WITH DIABETES AND COMORBID CONDITIONS
    David E Grembowski; Fiscal Year: 2010
    ..infarction, stroke, LDL- cholesterol, blood pressure, hemoglobin A1c (HbA1c), four co-morbid conditions, diabetes complications, Charlson co-morbidity index, drug adherence, diabetes treatment type, personal and plan characteristics, ..
  4. Determinants of Quality of Life in Elderly Adults with Diabetes
    Neda Laiteerapong; Fiscal Year: 2011
    ..A complicated interrelationship likely exists between traditional diabetes complications, geriatric syndromes, and quality of life...
  5. Oxidative insults, antioxidative responses and type 1 diabetes complications
    Tina Costacou; Fiscal Year: 2010
    ..observational historical prospective study of childhood onset diabetes - the Pittsburgh Epidemiology of Diabetes Complications (EDC) Study...
  6. ENHANCING CARBOHYDRATE QUALITY IN DIABETES TYPE - 1
    Lori Laffel; Fiscal Year: 2009
    Because the degree of diabetes complications is directly linked to the level of diabetes control, current diabetes regimens are placing increasing emphasis on maintenance of near-normal glycemia through the use of more intensive insulin ..
  7. Interactions of Lipoproteins and Cells in Diabetes Mellitus
    RICHARD LOUIS KLEIN; Fiscal Year: 2013
    ..S1P total concentration and relative distribution between the HDL and albumin pools in patients with diabetes complications compared to those without, and determine the association of S1P concentration and distribution with plasma ..
  8. Program ACTIVE II: Behavioral Depression Treatment for Type 2 Diabetes
    MARY K DE GROOT; Fiscal Year: 2013
    ..Depression is associated with worsened blood glucose levels and diabetes complications. Depression and T2DM also result in significant costs including: financial demands on health care systems, ..
  9. Genetic epidemiology of rare and regulatory variants for metabolic traits
    Karen L Mohlke; Fiscal Year: 2013
    ..biomarkers and metabolites, and behavioral and clinical diagnostic data were collected for diabetes, diabetes complications, and cardiovascular events...
  10. The Role of Apathy in Glycemic Control
    Cyrus V Desouza; Fiscal Year: 2011
    ..Apathy may be one of these factors since apathy leads to a loss of motivation and persistence. Treating apathy may lead to increased adherence to management regimens thus leading to better outcomes in diabetes. ..
  11. Effectiveness of Second Life in Promoting Diabetes Management
    SEANNE JO contact SAFAII FABIANO; Fiscal Year: 2010
    ..to improve diabetes self-management among young adults with diabetes thereby diminishing the severity of diabetes complications, and improve their quality of life...
  12. Two-way Interrelationships: Periodontal Disease, Diabetes and its Complications
    George Taylor; Fiscal Year: 2009
    ..poorer glycemic control;and if periodontal disease is associated with both the prevalence and incidence of diabetes complications and diabetes-related medical care utilization...
  13. Health system based clinical trial recruitment
    Trevor J Orchard; Fiscal Year: 2011
    ..provided by applicant): Reactive oxygen species have been implicated in the etiology and progression of diabetes complications, although clinical trials generally have not supported a protective effect of 1-tocopherol supplementation ..
  14. Pneumatic Medicine: A transformative treatment for diabetic peripheral neuropathy
    LAURA F JACOBS; Fiscal Year: 2010
    ..In the United States, diabetes complications are the leading cause of non-traumatic amputations, accounting for 86,000 of them annually...
  15. Systems Genetics of Type 1 Diabetes Complications
    Aldons Jake Lusis; Fiscal Year: 2011
    ..The goal of this project, identifying molecular mechanisms responsible for diabetes accelerated diseases, remains a critical goal in the drive to develop better treatments and preventative measures. ..
  16. Standardization of C-Peptide and HbA1C (UC4)
    Randie Little; Fiscal Year: 2012
    ..of endogenous insulin production in people with type 1diabetes is associated with significantly fewer diabetes complications. Measuring C-peptide levels with highly sensitive and standardized methods is therefore important now to ..
  17. Imaging biomarkers of accelerated brain aging in Type-1 Diabetes
    Caterina Rosano; Fiscal Year: 2013
    ..brain magnetization resonance imaging (MRI) from participants of the ongoing longitudinal Epidemiology of Diabetes Complications (EDC) cohort study (mean age [SD]: 48 [7...
  18. Relation of Primary Care Practice Variation to the Prevention of CVD and Diabetes
    THOMAS MICHAEL VOGT; Fiscal Year: 2010
    ..Cardiovascular Disease (ASCVD) Prevention Index (PI), which includes screening for CVD risk and risk of diabetes complications;and 2) the Time and Level of Control (TLC) of CVD and diabetes risk management...
  19. Diabetes and Periodontics Trial - Administrative Center/Study Chair
    Steven P Engebretson; Fiscal Year: 2012
    ..Improving the way people manage their blood sugar is key to preventing diabetes complications and reducing health care costs.
  20. The LIFE Program: A Behavioral Approach to Glycemic Control in African Americans
    Elizabeth B Lynch; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): African Americans experience rates of diabetes complications and hospitalization which are between 1.5 and 4 times greater than white patients...
  21. Pediatric Endocrine Fellowship Training in Diabetes Research
    CHARLES ALFRED STANLEY; Fiscal Year: 2012
    ..research opportunities will include Translational Research, Disease Mechanisms, Pathophysiology, Diabetes Complications, Genetics, Clinical Trials, Metabolic Syndrome, Nutrition, and Epidemiology...
  22. FL3X: An Adaptive Intervention to Improve Outcomes for Youth with Type 1 Diabetes
    Michael Seid; Fiscal Year: 2013
    ..secondary outcomes of motivation and problem solving skills, self-management behaviors, risk factors for diabetes complications, and health-related quality of life...
  23. Epidemiology of Diabetes Interventions and Complications Data Coordinating Center
    John M Lachin; Fiscal Year: 2013
    ..describe the study-long effects of glycemia (HbA1c) and other established and putative risk factors on diabetes complications and the metabolic memory effects of prior DCCT intensive therapy;and to expand knowledge regarding T1DM ..
  24. Hearing Impairment in Long-Term Type 1 Diabetes
    David S Schade; Fiscal Year: 2013
    ..Whether hearing loss is altered by the degree of present or past glucose control or the presence of other diabetes complications is unknown...
  25. BIOANALYTICAL REDOX BIOLOGY CORE
    W Timothy Garvey; Fiscal Year: 2012
    ..These services address key processes contributing to both metabolic and vascular pathology in diabetes, diabetes complications, and cardiometabolic disease...
  26. Computer Motivational Interventions to Improve Diabetes Care in Minority Youth
    Deborah A Ellis; Fiscal Year: 2012
    ..illness management in youth with type 1 diabetes leads to poor metabolic control, which in turn leads to diabetes complications. African-American adolescents in particular have been found to be at significantly higher risk for ..
  27. Career Development Program in Pediatric Diabetes Research (K12) at CHOP
    Steven M Willi; Fiscal Year: 2013
    ..and Regulation;2) Therapeutic Approaches to Islet Cell Preservation 3) Obesity and Insulin Resistance, 4) Diabetes Complications;and 5) Diabetes Epidemiology and Biostatistics...
  28. Optimizing Self-Management Adherence and Glycemic Control in Older Teens with T1D
    Lori M Laffel; Fiscal Year: 2013
    ..and glycemic control (blood glucose [BG] levels), disability and premature mortality from chronic diabetes complications remain common, highlighting the gap between treatment advances and robust patient uptake...
  29. Exhaled Gas Biomarkers of Glucose Metabolism in T2DM subjects
    TIMOTHY DO CHAU MINH; Fiscal Year: 2013
    ..variables;(2) investigate novel mechanisms of gas-cell interactions relevant to the pathogenesis of diabetes complications, VOC emission and functional response patterns in neutrophils...
  30. Epidemiology of Diabetes Complications (EDC) Phase II: renewal
    Trevor J Orchard; Fiscal Year: 2013
    ..Thus, the continuing investigation of type 1 diabetes complications remains imperative...
  31. Biological Variation in A1c on Mortality, Cardiovascular Events, Hypoglycemia
    James M Hempe; Fiscal Year: 2012
    ..Potential associations between HGI and diabetes complications other than microvascular have not been studied...
  32. Guideline Adherence and Short/Long-term Health Outcomes in Patients with Diabetes
    Maureen A Smith; Fiscal Year: 2013
    ..and death), (2) long-term and short-term A1c, LDL, and BP control and specific health outcomes (diabetes complications and possible drug-related morbidity), and (3) typical drug regimens used to achieve A1c, LDL, and BP ..
  33. Case Management for Underserved Hispanic Type 2 Diabetes Populations
    Garry W Welch; Fiscal Year: 2012
    ..key clinical outcomes (blood glucose, blood pressure, blood cholesterol control rates) and reduce serious diabetes complications. However, a clear gap exists between these evidence-based guidelines and diabetes care actually delivered ..
  34. Community-Based Diabetes Medical Nutritional Therapy in African American Women
    STEPHANIA T MILLER-HUGHES; Fiscal Year: 2012
    ..The target patient group is AA women ages 34 to 50 (n=24) who are at risk for Type 2 diabetes complications and enrolled in the MCO's diabetes management program...
  35. Vitamin D metabolism and type 1 diabetes complications
    Ian H De Boer; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Abstract Type 1 diabetes complications cause substantial morbidity and mortality...
  36. Diabetes Research Center (DRC)
    JERROLD MICHAEL OLEFSKY; Fiscal Year: 2013
    ..research base is comprised of the following focus areas: Nuclear Receptors, Cell Signaling, Metabolism, Diabetes Complications, and Islet/Beta Cell Biology...
  37. The Role of Nontraditional Glycemic Markers in Diabetes and Albuminuria
    April P Carson; Fiscal Year: 2013
    ..in helping the candidate gain expertise in the relation of glycemic markers and metabolomics with diabetes complications for establishing research independence...
  38. Community Health Worker Diabetes RCT for Latinos
    Michael S Spencer; Fiscal Year: 2012
    ..Ultimately, we believe such interventions hold one key to eliminating disparities in diabetes care and diabetes complications.
  39. Reducing Stress in Adolescents and Young Adults with T1D to Improve Diabetes Care
    Deborah A Ellis; Fiscal Year: 2012
    ..Older adolescents and young adults with poor diabetes management are at high risk for short and long-term diabetes complications and are also heavy users of health care dollars...
  40. Designing Research Training for Rwandans in Emerging HIV &Drug Therapy
    Eugene Mutimura; Fiscal Year: 2013
    ..Although data are limited on metabolic, cardiovascular and diabetes complications associated with HIV infection and treatment with cART, the country's disease burden is gradually ..
  41. Diabetes and Periodontics Trial - Coordinating Center
    Leslie G Hyman; Fiscal Year: 2012
    ..Improving the way people manage their blood sugar is key to preventing diabetes complications and reducing health care costs.
  42. Mechanisms of Renal Lipid Accumulation in Diabetic Nephropathy
    Lisa R Tannock; Fiscal Year: 2013
    ..Impact on Veterans Health Care: Veterans have very high prevalence of diabetes, hyperlipidemia and diabetes complications, including nephropathy...
  43. Identifying the Brain Substrates of Hypoglycemia Unawareness in Type 1 Diabetes
    Silvia Mangia; Fiscal Year: 2013
    ..HG) as they undergo insulin treatment to maintain the glucose control that is necessary to prevent diabetes complications. Recurrent HG can lead to development of the hypoglycemia-associated autonomic failure (HAAF) and to the ..
  44. Nonvisual Foot Examination for People with Diabetes and Visual Impairment
    Ann S Williams; Fiscal Year: 2012
    ..The potential downstream impact is reduced costs of care for diabetes complications on the population level...
  45. ADHERENCE TO IDDM REGIMEN IN URBAN YOUTH
    Deborah A Ellis; Fiscal Year: 2010
    ..Adolescents with CPMC represent a group at high risk for short and long-term diabetes complications and are therefore heavy users of both medical resources and health care dollars...
  46. Urban Indian Diabetes Prevention Planning Project
    Michelle Chino; Fiscal Year: 2010
    ..the goal of improving modifiable risk factors, to ultimately achieve good glucose control, and prevent diabetes complications. American Indians/Alaska Natives living in urban settings are at high risk for diabetes and its ..
  47. EPIDEMIOLOGY OF DIABETES INTERVENTIONS AND COMPLICATIONS (EDIC)
    Rose A Gubitosi-Klug; Fiscal Year: 2013
    ..accurately the study-long effects of glycemia (HbA1c) and other established and putative risk factors on diabetes complications and the metabolic memory effects of prior DCCT intensive therapy;and to expand knowledge regarding T1DM ..
  48. Does Variation in Mean Red Cell Age Impact HbA1c Interpretation?
    ROBERT MAYNARD COHEN; Fiscal Year: 2013
    ..is the most highly valued clinical test for long term monitoring of glycemic control and the prediction of diabetes complications risk is relied upon for hundreds of thousands of clinical decisions made every year in veterans with ..
  49. CAREER DEVELOPMENT IN DIABETES RESEARCH FOR PEDIATRIC ENDOCRINOLOGISTS
    Morris F White; Fiscal Year: 2013
    ..the challenges of achieving optimal glycemic control in youth, the high risk of short- and long-term diabetes complications, the need for additional research to increase our understanding of uncommon genetic forms of diabetes, the ..
  50. Type 1 Diabetes TrialNet: Toronto Clinical Centre
    DIANE K WHERRETT; Fiscal Year: 2013
    ..Preserved endogenous insulin secretion has been found to be associated with reduced of rates of the diabetes complications of hypoglycemia, nephropathy and retinopathy.
  51. Diabetes Research Center
    Jean E Schaffer; Fiscal Year: 2013
    ..interacting scientific themes-a) Approaches Across the Translational Spectrum, and b) Prevention of Diabetes Complications. Evidence that the WUMS DRC continues to successfully pursue the mission outlined in this renewal ..
  52. Race and Long-Term Diabetes Self-Management in an HMO
    Dennis Ross Degnan; Fiscal Year: 2004
    ..including self-monitoring of blood glucose and diabetes drug therapy), glycemic control, and diabetes complications in a managed care setting over a nine-year period...
  53. DIABETES RISK FACTORS IN ALASKAN AND SIBERIAN ESKIMOS
    Sven Ebbesson; Fiscal Year: 1991
    ..data and attempt to correlate these with the occurrence of diabetes, cardiovascular risk factors, diabetes complications, and insulin levels...
  54. From Adolescence to Adulthood: Persons with and without Diabetes
    Vicki S Helgeson; Fiscal Year: 2013
    ..of complications to a comparable cohort (in terms of age and length of diabetes) from the Epidemiology of Diabetes Complications Trial;and (4) To utilize a "Risk and Resistance Framework" to predict psychological, behavioral, and ..
  55. DIABETES IN PACIFIC--ENVIRONMENTAL/GENETIC DETERMINANTS
    Paul Zimmet; Fiscal Year: 1999
    ..primary prevention of NIDDM and other CVD risk factors, as well as secondary and tertiary prevention of diabetes complications; 6) investigate the extent and biological importance of the Metabolic Syndrome (CVD risk factor cluster) ..
  56. PREVENTING DEPRESSION RECURRENCE IN DIABETES
    Patrick Lustman; Fiscal Year: 2002
    DESCRIPTION: Major depression in diabetes is a prevalent condition associated with an increased risk of diabetes complications. The investigators recently proved that short-term treatment of depression with antidepressants in diabetes is ..
  57. Cross-Cultural Validity of Cognitive Function Tests
    Valory Pavlik; Fiscal Year: 2005
    ..S., African-Americans and Hispanics, are at higher risk for diabetes and certain diabetes complications than non-Hispanic whites...
  58. Depression and Insulin Resistance in Type 2 Diabetes
    Patrick Lustman; Fiscal Year: 2006
    ..IR characterizes type 2 diabetes (T2DM) and is a predictor of diabetes complications, particularly coronary heart disease (CHD)...
  59. Preclinical study of efficacy in animal models of diabetic complications
    JEAN LINDER; Fiscal Year: 2009
    ..This Diabetes Complications Efficacy Evaluation Contract shall assess the efficacy and mechanism of new drugs under development with ..
  60. Autonomic Function in Insulin Resistance and Diabetes
    Mercedes Carnethon; Fiscal Year: 2005
    ..to physical and pharmacological provocation, predisposes persons to the development of diabetes and diabetes complications, including CVD, when impaired...
  61. COMPLIANCE AND CONTROL IN CHILDHOOD DIABETES
    Suzanne Johnson; Fiscal Year: 1999
    ..Annual diabetes care and disability costs are greater than $20 billion. In 1982, the Diabetes Complications and Control Trial (DCCT) was initiated to test whether intensive therapy (IT) (a rigorous regimen of ..
  62. Latina Diabetics and Body Image
    Patricia Weitzman; Fiscal Year: 2006
    ..provided by applicant): Preventive health care is the cornerstone of primary and secondary prevention of diabetes complications. In the U.S., Latinas have a higher lifetime risk for developing diabetes than any other group -- 52...