diabetes mellitus

Summary

Summary: A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.

Top Publications

  1. ncbi Global prevalence of diabetes: estimates for the year 2000 and projections for 2030
    Sarah Wild
    Public Health Sciences, University of Edinburgh, Edinburgh, Scotland
    Diabetes Care 27:1047-53. 2004
  2. ncbi Biochemistry and molecular cell biology of diabetic complications
    M Brownlee
    Department of Medicine, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York, 10461, USA
    Nature 414:813-20. 2001
  3. doi National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants
    Goodarz Danaei
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Lancet 378:31-40. 2011
  4. pmc Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies
    N Sarwar
    Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK
    Lancet 375:2215-22. 2010
  5. ncbi Prevalence of chronic kidney disease in the United States
    Josef Coresh
    Department of Epidemiology, Bloomberg School of Public Health, and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, Maryland 21287, USA
    JAMA 298:2038-47. 2007
  6. ncbi Prediction of coronary heart disease using risk factor categories
    P W Wilson
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Mass 01701, USA
    Circulation 97:1837-47. 1998
  7. doi Global estimates of the prevalence of diabetes for 2010 and 2030
    J E Shaw
    Epidemiology, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Diabetes Res Clin Pract 87:4-14. 2010
  8. ncbi Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections
    H King
    Division of Noncommunicable Diseases, World Health Organization, Geneva, Switzerland
    Diabetes Care 21:1414-31. 1998
  9. doi Diabetes mellitus and the β cell: the last ten years
    Frances M Ashcroft
    Department of Physiology, Anatomy, and Genetics, Henry Wellcome Centre for Gene Function, University of Oxford, Sherrington Building, Parks Road, Oxford OX1 3PT, UK
    Cell 148:1160-71. 2012
  10. ncbi Follow-up report on the diagnosis of diabetes mellitus
    Saul Genuth
    Diabetes Care 26:3160-7. 2003

Detail Information

Publications385 found, 100 shown here

  1. ncbi Global prevalence of diabetes: estimates for the year 2000 and projections for 2030
    Sarah Wild
    Public Health Sciences, University of Edinburgh, Edinburgh, Scotland
    Diabetes Care 27:1047-53. 2004
    ..The goal of this study was to estimate the prevalence of diabetes and the number of people of all ages with diabetes for years 2000 and 2030...
  2. ncbi Biochemistry and molecular cell biology of diabetic complications
    M Brownlee
    Department of Medicine, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York, 10461, USA
    Nature 414:813-20. 2001
    ..This integrating paradigm provides a new conceptual framework for future research and drug discovery...
  3. doi National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants
    Goodarz Danaei
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Lancet 378:31-40. 2011
    ..We estimated trends and their uncertainties in mean fasting plasma glucose (FPG) and diabetes prevalence for adults aged 25 years and older in 199 countries and territories...
  4. pmc Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies
    N Sarwar
    Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK
    Lancet 375:2215-22. 2010
    Uncertainties persist about the magnitude of associations of diabetes mellitus and fasting glucose concentration with risk of coronary heart disease and major stroke subtypes...
  5. ncbi Prevalence of chronic kidney disease in the United States
    Josef Coresh
    Department of Epidemiology, Bloomberg School of Public Health, and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, Maryland 21287, USA
    JAMA 298:2038-47. 2007
    ..Whether there have been changes in the prevalence of earlier stages of chronic kidney disease (CKD) during this period is uncertain...
  6. ncbi Prediction of coronary heart disease using risk factor categories
    P W Wilson
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Mass 01701, USA
    Circulation 97:1837-47. 1998
    ....
  7. doi Global estimates of the prevalence of diabetes for 2010 and 2030
    J E Shaw
    Epidemiology, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Diabetes Res Clin Pract 87:4-14. 2010
    ..We estimated the number of people worldwide with diabetes for the years 2010 and 2030...
  8. ncbi Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections
    H King
    Division of Noncommunicable Diseases, World Health Organization, Geneva, Switzerland
    Diabetes Care 21:1414-31. 1998
    ..e., the years 1995, 2000, and 2025, and to calculate additional parameters, such as sex ratio, urban-rural ratio, and the age structure of the diabetic population...
  9. doi Diabetes mellitus and the β cell: the last ten years
    Frances M Ashcroft
    Department of Physiology, Anatomy, and Genetics, Henry Wellcome Centre for Gene Function, University of Oxford, Sherrington Building, Parks Road, Oxford OX1 3PT, UK
    Cell 148:1160-71. 2012
    ..There also have been significant advances in therapy, particularly for some monogenic disorders. We review here what ails the β cell and how its function may be restored...
  10. ncbi Follow-up report on the diagnosis of diabetes mellitus
    Saul Genuth
    Diabetes Care 26:3160-7. 2003
  11. ncbi The prevalence of comorbid depression in adults with diabetes: a meta-analysis
    R J Anderson
    Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA
    Diabetes Care 24:1069-78. 2001
    ..CONCLUSIONS--The presence of diabetes doubles the odds of comorbid depression. Prevalence estimates are affected by several clinical and methodological variables that do not affect the stability of the ORs...
  12. pmc Glycated hemoglobin, diabetes, and cardiovascular risk in nondiabetic adults
    Elizabeth Selvin
    Department of Epidemiology and the Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21287, USA
    N Engl J Med 362:800-11. 2010
    ..Fasting glucose is the standard measure used to diagnose diabetes in the United States. Recently, glycated hemoglobin was also recommended for this purpose...
  13. doi Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 359:2195-207. 2008
    ....
  14. ncbi Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence
    Earl S Ford
    Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Diabetes Care 28:1769-78. 2005
    ....
  15. ncbi The role for endoplasmic reticulum stress in diabetes mellitus
    Decio L Eizirik
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Route de Lennik, 808 CP 618, 1070 Brussels, Belgium
    Endocr Rev 29:42-61. 2008
    ..A better understanding of the pathways regulating ER stress in beta-cells may be instrumental for the design of novel therapies to prevent beta-cell loss in diabetes...
  16. ncbi Risk of dementia in diabetes mellitus: a systematic review
    Geert Jan Biessels
    Department of Neurology, Rudolf Magnus Institute of Neurosciences, University Medical Center Utrecht, Netherlands
    Lancet Neurol 5:64-74. 2006
    ..This systematic review examines the incidence of dementia in people with diabetes mellitus. We identified 14 eligible longitudinal population-based studies of variable methodological quality...
  17. pmc Prevalence of diabetes and high risk for diabetes using A1C criteria in the U.S. population in 1988-2006
    Catherine C Cowie
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Diabetes Care 33:562-8. 2010
    ..CONCLUSIONS Although A1C detects much lower prevalences than glucose criteria, hyperglycemic conditions remain high in the U.S., and elderly and minority groups are disproportionately affected...
  18. ncbi Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD(P)H oxidase and endothelial nitric oxide synthase
    Tomasz J Guzik
    Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
    Circulation 105:1656-62. 2002
    ..We characterized the sources and mechanisms underlying vascular superoxide production in human blood vessels from diabetic patients with coronary artery disease compared with nondiabetic patients...
  19. ncbi Improving primary care for patients with chronic illness
    Thomas Bodenheimer
    Family and Community Medicine, University of California, San Francisco, USA
    JAMA 288:1775-9. 2002
    ..Case studies are provided describing how components of the chronic care model have been implemented in the primary care practices of 4 health care organizations...
  20. doi Statin use and risk of diabetes mellitus in postmenopausal women in the Women's Health Initiative
    Annie L Culver
    Rochester Methodist Hospital, MayoClinic, Rochester, MN, USA
    Arch Intern Med 172:144-52. 2012
    This study investigates whether the incidence of new-onset diabetes mellitus (DM) is associated with statin use among postmenopausal women participating in the Women's Health Initiative (WHI).
  21. pmc Translating the Diabetes Prevention Program into the community. The DEPLOY Pilot Study
    Ronald T Ackermann
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Am J Prev Med 35:357-63. 2008
    ..This study evaluated the delivery of a group-based DPP lifestyle intervention in partnership with the YMCA...
  22. ncbi Impaired glucose tolerance and impaired fasting glycaemia: the current status on definition and intervention
    N Unwin
    Diabetes and Metabolism, School of Clinical Medical Sciences, University of New Castle, UK
    Diabet Med 19:708-23. 2002
    ..4. Life style interventions are highly effective in delaying or preventing the onset of diabetes in people with IGT and may reduce CVD and total mortality, but the latter requires formal testing...
  23. ncbi European guidelines on cardiovascular disease prevention in clinical practice: full text. Fourth Joint Task Force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by represent
    Ian Graham
    Department of Cardiology, The Adelaide and Meath Hospital, Tallaght, Dublin, Ireland
    Eur J Cardiovasc Prev Rehabil 14:S1-113. 2007
  24. doi Diabetes in sub-Saharan Africa
    Jean Claude N Mbanya
    Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon
    Lancet 375:2254-66. 2010
    ..A multisectoral approach to diabetes control and care is vital for expansion of socioculturally appropriate diabetes programmes in sub-Saharan African countries...
  25. doi Diabetes and risk of bladder cancer: a study using the National Health Insurance database in Taiwan
    C H Tseng
    Department of Internal Medicine, National Taiwan University Hospital, No 7 Chung Shan South Road, Taipei 100, Taiwan, Republic of China
    Diabetologia 54:2009-15. 2011
    ..Studies on the link between diabetes and bladder cancer in Asians are rare. We investigated the association between diabetes and incidence of bladder cancer by using a large national insurance database...
  26. ncbi Serum 25-hydroxyvitamin D, diabetes, and ethnicity in the Third National Health and Nutrition Examination Survey
    Robert Scragg
    School of Population Health, University of Auckland, Private Bag, Auckland, New Zealand
    Diabetes Care 27:2813-8. 2004
    ..To determine the association between serum 25-hydroxyvitamin D (25OHD) and diabetes risk and whether it varies by ethnicity...
  27. ncbi Primary prevention of cardiovascular diseases in people with diabetes mellitus: a scientific statement from the American Heart Association and the American Diabetes Association
    John B Buse
    University of North Carolina, USA
    Circulation 115:114-26. 2007
    ..This statement will attempt to harmonize the recommendations of both organizations where possible but will recognize areas in which AHA and ADA recommendations differ...
  28. ncbi The continuing epidemics of obesity and diabetes in the United States
    A H Mokdad
    Data Management Division, National Immunization Program, Centers for Disease Control and Prevention, MS E62, 1600 Clifton Rd, NE, Atlanta, GA 30333, USA
    JAMA 286:1195-200. 2001
    ..Recent reports show that obesity and diabetes have increased in the United States in the past decade...
  29. ncbi Medicinal plants of India with anti-diabetic potential
    J K Grover
    Department of Pharmacology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110049, India
    J Ethnopharmacol 81:81-100. 2002
    ..charantia, Eugenia jambolana, Mucuna pruriens, T. cordifolia, T. foenum graecum, O. sanctum, P. marsupium, Murraya koeingii and Brassica juncea. All plants have shown varying degree of hypoglycemic and anti-hyperglycemic activity...
  30. ncbi Diabetes and cardiovascular disease during androgen deprivation therapy for prostate cancer
    Nancy L Keating
    Division of General Internal Medicine, Department of Medicine, Brigham and Women s Hospital, USA
    J Clin Oncol 24:4448-56. 2006
    ..We assessed whether androgen deprivation therapy is associated with an increased incidence of diabetes and cardiovascular disease...
  31. ncbi The hormone resistin links obesity to diabetes
    C M Steppan
    Department of Medicine, The Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Nature 409:307-12. 2001
    b>Diabetes mellitus is a chronic disease that leads to complications including heart disease, stroke, kidney failure, blindness and nerve damage...
  32. ncbi KATP channels as molecular sensors of cellular metabolism
    Colin G Nichols
    Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nature 440:470-6. 2006
    ..In parallel, the uncovering of disease-causing mutations of K(ATP) has led to an explanation of the molecular basis of disease and, in turn, to a better understanding of the structural basis of channel function...
  33. doi Diabetes and cancer: a consensus report
    Edward Giovannucci
    Departments of Nutrition and Epidemiology, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA
    CA Cancer J Clin 60:207-21. 2010
    ..In addition, key unanswered questions for future research are posed...
  34. pmc Risk of malignancies in patients with diabetes treated with human insulin or insulin analogues: a cohort study
    L G Hemkens
    Institute for Quality and Efficiency in Health Care IQWiG, Dillenburger Strasse 27, D 51105, Cologne, Germany
    Diabetologia 52:1732-44. 2009
    ..The aim of this cohort study was to investigate the risk of malignant neoplasms and mortality in patients with diabetes treated either with human insulin or with one of three insulin analogues...
  35. doi Cancer occurrence in Danish diabetic patients: duration and insulin effects
    B Carstensen
    Steno Diabetes Center, Niels Steensens Vej 2, 2829, Gentofte, Denmark
    Diabetologia 55:948-58. 2012
    ..Cancer is more frequent among diabetes patients, but it is unknown how this excess varies with duration of diabetes and insulin use. The aim of this study was to analyse disease data to examine this issue further...
  36. pmc Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus
    David B Sacks
    Department of Laboratory Medicine, National Institutes of Health, Bethesda, Maryland, USA
    Diabetes Care 34:e61-99. 2011
    Multiple laboratory tests are used to diagnose and manage patients with diabetes mellitus. The quality of the scientific evidence supporting the use of these tests varies substantially.
  37. ncbi Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines
    Scott M Grundy
    Circulation 110:227-39. 2004
    ..Finally, for people in lower-risk categories, recent clinical trials do not modify the goals and cutpoints of therapy...
  38. doi Risk of incident diabetes with intensive-dose compared with moderate-dose statin therapy: a meta-analysis
    David Preiss
    BHF Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Pl, Glasgow G12 8TA, Scotland, United Kingdom
    JAMA 305:2556-64. 2011
    A recent meta-analysis demonstrated that statin therapy is associated with excess risk of developing diabetes mellitus.
  39. doi Global healthcare expenditure on diabetes for 2010 and 2030
    Ping Zhang
    Division of Diabetes Translation, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Diabetes Res Clin Pract 87:293-301. 2010
    ..To estimate the global health expenditure on diabetes among people aged 20-79 years for the years 2010 and 2030...
  40. pmc Non-communicable diseases in low- and middle-income countries: context, determinants and health policy
    J J Miranda
    Non communicable Disease Epidemiology Unit, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Trop Med Int Health 13:1225-34. 2008
    ..Finally, the need for health system reform to strengthen primary care is highlighted as a major policy to reduce the toll of this rising epidemic...
  41. pmc Depression and diabetes treatment nonadherence: a meta-analysis
    Jeffrey S Gonzalez
    Behavioral Medicine, Department of Psychiatry, Massachusetts General Hospital Boston, Boston, Massachusetts, USA
    Diabetes Care 31:2398-403. 2008
    ..Its relationship to treatment adherence, however, has not been systematically reviewed. We used meta-analysis to examine the relationship between depression and treatment nonadherence in patients with type 1 and type 2 diabetes...
  42. ncbi Diabetes mellitus and risk of breast cancer: a meta-analysis
    Susanna C Larsson
    Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 121:856-62. 2007
    b>Diabetes mellitus has been associated with an increased risk of several types of cancers, but its relationship with breast cancer remains unclear...
  43. ncbi Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus
    David B Sacks
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Thorn 530, 75 Francis St, Boston, MA 02115, USA
    Clin Chem 48:436-72. 2002
    Multiple laboratory tests are used in the diagnosis and management of patients with diabetes mellitus. The quality of the scientific evidence supporting the use of these assays varies substantially.
  44. pmc Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer
    Sao Jiralerspong
    Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, 77030 4009, USA
    J Clin Oncol 27:3297-302. 2009
    ..Our purpose was to determine whether metformin use was associated with a change in pathologic complete response (pCR) rates in diabetic patients with breast cancer receiving neoadjuvant chemotherapy...
  45. ncbi Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia
    P D Cani
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Universite Catholique de Louvain, Av E Mounier, 73 69, 1200 Brussels, Belgium
    Diabetologia 50:2374-83. 2007
    ..caecal content in mice. We therefore tested whether restoration of the quantity of caecal Bifidobacterium spp. could modulate metabolic endotoxaemia, the inflammatory tone and the development of diabetes...
  46. ncbi Trends in diabetes prevalence, incidence, and mortality in Ontario, Canada 1995-2005: a population-based study
    Lorraine L Lipscombe
    Institute for Clinical Evaluative Sciences, Toronto, ON, Canada
    Lancet 369:750-6. 2007
    ..The prevalence of diabetes has been increasing greatly, but WHO's predicted 39% rise in the global rate of diabetes from 2000 to 2030 might be an underestimate. We aimed to assess diabetes trends in Ontario, Canada...
  47. ncbi Ethnic disparities in diabetic complications in an insured population
    Andrew J Karter
    Division of Research, Kaiser Permanente, 2000 Broadway, Oakland, CA 94612, USA
    JAMA 287:2519-27. 2002
    ..Disparate access to quality health care is a common explanation for ethnic disparities in diabetic complication rates in the US population. Examining an ethnically diverse population with uniform health care coverage may be useful...
  48. doi EUROASPIRE III. Management of cardiovascular risk factors in asymptomatic high-risk patients in general practice: cross-sectional survey in 12 European countries
    Kornelia Kotseva
    Department of Cardiovascular Medicine, National Heart and Lung Institute, Imperial College London, London, UK
    Eur J Cardiovasc Prev Rehabil 17:530-40. 2010
    ..To determine whether the 2003 Joint European Societies' guidelines on cardiovascular disease prevention in people at high cardiovascular risk have been followed in general practice...
  49. doi Prevalence and projections of diabetes and pre-diabetes in adults in Sri Lanka--Sri Lanka Diabetes, Cardiovascular Study (SLDCS)
    P Katulanda
    Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, UK
    Diabet Med 25:1062-9. 2008
    To determine the prevalence of diabetes mellitus and pre-diabetes (impaired fasting glucose and impaired glucose tolerance) in adults in Sri Lanka...
  50. pmc Body mass index and diabetes in Asia: a cross-sectional pooled analysis of 900,000 individuals in the Asia cohort consortium
    Paolo Boffetta
    Mount Sinai School of Medicine, The Tisch Cancer Institute, New York, New York, United States of America
    PLoS ONE 6:e19930. 2011
    ..The shape of the association of overweight and obesity with diabetes risk and its overall impact have not been adequately studied in Asia...
  51. doi Telmisartan, ramipril, or both in patients at high risk for vascular events
    Salim Yusuf
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 358:1547-59. 2008
    ..We compared the ACE inhibitor ramipril, the ARB telmisartan, and the combination of the two drugs in patients with vascular disease or high-risk diabetes...
  52. ncbi Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes
    Anna L Gloyn
    Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, United Kingdom
    N Engl J Med 350:1838-49. 2004
    ..2 subunit of this channel (KCNJ11) cause neonatal diabetes...
  53. ncbi Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators
    S Yusuf
    Canadian Cardiovascular Collaboration Project Office, Hamilton General Hospital, McMaster University, ON
    N Engl J Med 342:145-53. 2000
    ..We assessed the role of an angiotensin-converting-enzyme inhibitor, ramipril, in patients who were at high risk for cardiovascular events but who did not have left ventricular dysfunction or heart failure...
  54. ncbi Agreement between self-report questionnaires and medical record data was substantial for diabetes, hypertension, myocardial infarction and stroke but not for heart failure
    Yuji Okura
    Division of Cardiovascular Diseases and Internal Medicine, Department of Health Science Research, Mayo Clinic and Foundation, 200 First St SW, Rochester, Minnesota 55905, USA
    J Clin Epidemiol 57:1096-103. 2004
    ..Agreement between questionnaire responses and a criterion standard is important for optimal disease prevalence estimates. We measured the agreement between self-reported disease and medical record diagnosis of disease...
  55. doi The relationship between diabetes mellitus and traffic-related air pollution
    Robert D Brook
    Division of Cardiovascular Medicine, University of Michigan, 24 Frank Lloyd Wright Drive, Ann Arbor, MI 48106, USA
    J Occup Environ Med 50:32-8. 2008
    ..Many of the biological pathways involved could also promote diabetes mellitus (DM)...
  56. pmc Effect of laparoscopic Roux-en Y gastric bypass on type 2 diabetes mellitus
    Philip R Schauer
    Departments of Surgery, University of Pittsburg, Pittsburgh, PA, USA
    Ann Surg 238:467-84; discussion 84-5. 2003
    To evaluate pre- and postoperative clinical parameters associated with improvement of diabetes up to 4 years after laparoscopic Roux-en-Y gastric bypass (LRYGBP) in patients with type 2 diabetes mellitus (T2DM).
  57. ncbi Closing the loop: physician communication with diabetic patients who have low health literacy
    Dean Schillinger
    Primary Care Research Center, Department of Medicine, University of California San Francisco, San Francisco General Hospital, 94110, USA
    Arch Intern Med 163:83-90. 2003
    ..It is not known how frequently physicians apply this interactive educational strategy, or whether it is associated with improved health outcomes...
  58. pmc Full accounting of diabetes and pre-diabetes in the U.S. population in 1988-1994 and 2005-2006
    Catherine C Cowie
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Diabetes Care 32:287-94. 2009
    ..S. during 2005-2006. We then compared the prevalences of these conditions with those in 1988-1994...
  59. doi Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus
    David B Sacks
    Department of Laboratory Medicine, National Institutes of Health, Bethesda, MD 20892 1508, USA
    Clin Chem 57:e1-e47. 2011
    Multiple laboratory tests are used to diagnose and manage patients with diabetes mellitus. The quality of the scientific evidence supporting the use of these tests varies substantially.
  60. doi Diabetes prevalence and therapeutic target achievement in the United States, 1999 to 2006
    Bernard M Y Cheung
    Department of Clinical Pharmacology, School of Clinical and Experimental Medicine, University of Birmingham, United Kingdom
    Am J Med 122:443-53. 2009
    ..Changes in the prevalence, treatment, and management of diabetes in the United States from 1999 to 2006 were studied using data from the National Health and Nutrition Examination Survey...
  61. ncbi Improving primary care for patients with chronic illness: the chronic care model, Part 2
    Thomas Bodenheimer
    Family and Community Medicine, University of California, San Francisco, USA
    JAMA 288:1909-14. 2002
    ..Even though the chronic care model has the potential to improve care and reduce costs, several obstacles hinder its widespread adoption...
  62. doi Prevalence of diabetes among men and women in China
    Wenying Yang
    China Japan Friendship Hospital, Beijing, China
    N Engl J Med 362:1090-101. 2010
    ..Because of the rapid change in lifestyle in China, there is concern that diabetes may become epidemic. We conducted a national study from June 2007 through May 2008 to estimate the prevalence of diabetes among Chinese adults...
  63. pmc Effect of weight loss with lifestyle intervention on risk of diabetes
    Richard F Hamman
    Diabetes Prevention Program Coordinating Center, The Biostatistics Center, George Washington University, 6110 Executive Blvd, Suite 750, Rockville, MD 20852, USA
    Diabetes Care 29:2102-7. 2006
    ..We explored the contribution of changes in weight, diet, and physical activity on the risk of developing diabetes among ILS participants...
  64. ncbi Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations
    Ewan R Pearson
    Institute of Biomedical and Clinical Sciences, Peninsula Medical School, Exeter, United Kingdom
    N Engl J Med 355:467-77. 2006
    ..Diabetes results from impaired insulin secretion caused by a failure of the beta-cell K(ATP) channel to close in response to increased intracellular ATP. Sulfonylureas close the K(ATP) channel by an ATP-independent route...
  65. ncbi Impact of diabetes on cardiac structure and function: the strong heart study
    R B Devereux
    New York Hospital Cornell Medical Center, New York, USA
    Circulation 101:2271-6. 2000
    Whether diabetes mellitus (DM) adversely affects left ventricular (LV) structure and function independently of increases in body mass index (BMI) and blood pressure is controversial.
  66. ncbi Report of the Committee on the classification and diagnostic criteria of diabetes mellitus
    Takeshi Kuzuya
    Aino Institute for Aging Research, Ibaraki shi, Osaka Fu, Japan
    Diabetes Res Clin Pract 55:65-85. 2002
    In 1995, the Japan Diabetes Society (JDS) appointed the Committee for the Classification and Diagnosis of Diabetes Mellitus. The Committee presented a final report in May 1999 in Japanese...
  67. ncbi Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: Part I
    Mark A Creager
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, Mass 02115, USA
    Circulation 108:1527-32. 2003
  68. ncbi Evaluating the quality of self-reports of hypertension and diabetes
    Noreen Goldman
    Office of Population Research, Princeton University, 243 Wallace Hall, Princeton, NJ 08544 2091, USA
    J Clin Epidemiol 56:148-54. 2003
    ..Significant correlates of the accuracy of the self-reports include age, education, time of the most recent health exam, and cognitive function...
  69. ncbi The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21
    Alexei Kharitonenkov
    Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Endocrinology 148:774-81. 2007
    ..These data support the development of FGF-21 for the treatment of diabetes and other metabolic diseases...
  70. ncbi Diabetes mellitus and the risk of cancer: results from a large-scale population-based cohort study in Japan
    Manami Inoue
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Arch Intern Med 166:1871-7. 2006
    An association between diabetes mellitus (DM) and cancer has long been speculated, but no conclusive evidence has been obtained.
  71. doi Oxidative stress and diabetes mellitus
    Hui Yang
    Department of Laboratory Medicine, China Japan Friendship Hospital, Ministry of Health, Beijing, PR China
    Clin Chem Lab Med 49:1773-82. 2011
    Increasing evidences have suggested that oxidative stress plays a major role in the pathogenesis of diabetes mellitus (DM). Oxidative stress also appears to be the pathogenic factor in underlying diabetic complications...
  72. ncbi Incident diabetes in clinical trials of antihypertensive drugs: a network meta-analysis
    William J Elliott
    Department of Preventive Medicine, Rush Medical College of Rush University at Rush University Medical Center, Chicago, IL 60612, USA
    Lancet 369:201-7. 2007
    The effect of different classes of antihypertensive drugs on incident diabetes mellitus is controversial because traditional meta-analyses are hindered by heterogeneity across trials and the absence of trials comparing angiotensin-..
  73. ncbi Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes
    Peter Gaede
    Steno Diabetes Center, Copenhagen, Denmark
    N Engl J Med 348:383-93. 2003
    ....
  74. pmc Long-term all-cause mortality in cancer patients with preexisting diabetes mellitus: a systematic review and meta-analysis
    Bethany B Barone
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    JAMA 300:2754-64. 2008
    b>Diabetes mellitus appears to be a risk factor for some cancers, but the effect of preexisting diabetes on all-cause mortality in newly diagnosed cancer patients is less clear.
  75. pmc Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes
    David M Nathan
    Diabetes Center, Massachusetts General Hospital, Boston, Massachusetts, USA
    Diabetes Care 32:193-203. 2009
    ..In this revision, we focus on the new classes of medications that now have more clinical data and experience...
  76. doi Insulin and insulin-like growth factor signalling in neoplasia
    Michael Pollak
    Department of Oncology, McGill University, Montreal, Quebec, Canada
    Nat Rev Cancer 8:915-28. 2008
    ..Recent results are encouraging and have justified the expansion of many translational research programmes...
  77. ncbi Quality of life and diabetes
    R R Rubin
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Diabetes Metab Res Rev 15:205-18. 1999
    ..Methodologically, it is important to use multidimensional assessments of quality of life, and to include both generic and disease-specific measures. Quality of life measures should be used to guide and evaluate treatment interventions...
  78. pmc The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes
    Donalyn Scheuner
    Department of Biological Chemistry, and Howard Hughes Medical Institute, The University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Endocr Rev 29:317-33. 2008
    ..Therapeutic interventions to prevent polypeptide-misfolding, oxidative damage, and/or UPR-induced cell death have the potential to improve beta-cell function and/or survival in the treatment of diabetes...
  79. pmc Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1
    Mary Elizabeth Patti
    Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 100:8466-71. 2003
    Type 2 diabetes mellitus (DM) is characterized by insulin resistance and pancreatic beta cell dysfunction. In high-risk subjects, the earliest detectable abnormality is insulin resistance in skeletal muscle...
  80. doi Trends in the prevalence of preexisting diabetes and gestational diabetes mellitus among a racially/ethnically diverse population of pregnant women, 1999-2005
    Jean M Lawrence
    Research and Evaluation, Kaiser Permanente Southern California, 100 S Los Robles, 2nd Floor, Pasadena, CA 91101, USA
    Diabetes Care 31:899-904. 2008
    The purpose of this study was to assess changes in the prevalence of preexisting diabetes (diabetes antedating pregnancy) and gestational diabetes mellitus (GDM) from 1999 through 2005.
  81. pmc Diabetes and tuberculosis: the impact of the diabetes epidemic on tuberculosis incidence
    Catherine R Stevenson
    Medical Research Council Epidemiology Unit, Cambridge, UK
    BMC Public Health 7:234. 2007
    ..Diabetes increases the risk of TB. Our aim was to assess the potential impact of diabetes as a risk factor for incident pulmonary tuberculosis, using India as an example...
  82. ncbi Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Mass, USA
    Circulation 116:39-48. 2007
    ..The incremental utility of measuring both visceral and subcutaneous abdominal adipose tissue (SAT) in association with metabolic risk factors and underlying heritability has not been well described in a population-based setting...
  83. pmc International Day for the Evaluation of Abdominal Obesity (IDEA): a study of waist circumference, cardiovascular disease, and diabetes mellitus in 168,000 primary care patients in 63 countries
    Beverley Balkau
    INSERM U780 IFR69, Research in Epidemiology and Biostatistics, 16 Ave Paul Vaillant Couturier, 94807 Villejuif, France
    Circulation 116:1942-51. 2007
    ..It is not known whether it is similarly associated with cardiovascular disease (CVD) and diabetes mellitus in different regions around the world, and thus whether measurement of waist circumference (WC) in addition ..
  84. pmc Diabetes and cancer: a consensus report
    Edward Giovannucci
    Department of Nutrition, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Diabetes Care 33:1674-85. 2010
    ..In addition, key unanswered questions for future research are posed...
  85. doi UN High-Level Meeting on Non-Communicable Diseases: addressing four questions
    Robert Beaglehole
    University of Auckland, Auckland, New Zealand
    Lancet 378:449-55. 2011
    ..Long-term success requires inspired and committed national and international leadership...
  86. pmc Endoplasmic reticulum stress: cell life and death decisions
    Chunyan Xu
    The Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Clin Invest 115:2656-64. 2005
    ..Important roles for ER-initiated cell death pathways have been recognized for several diseases, including hypoxia, ischemia/reperfusion injury, neurodegeneration, heart disease, and diabetes...
  87. ncbi The rising prevalence of diabetes and impaired glucose tolerance: the Australian Diabetes, Obesity and Lifestyle Study
    David W Dunstan
    International Diabetes Institute, Melbourne, Australia
    Diabetes Care 25:829-34. 2002
    ....
  88. ncbi Prevalence of diabetes and impaired fasting glucose in the Chinese adult population: International Collaborative Study of Cardiovascular Disease in Asia (InterASIA)
    D Gu
    Cardiovascular Institute and Fuwai Hospital of Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
    Diabetologia 46:1190-8. 2003
    ..To estimate the prevalence of diagnosed and undiagnosed diabetes and impaired fasting glucose in the general adult population of China...
  89. pmc Glycated hemoglobin and associated risk factors in older adults
    Raul A Martins
    Faculty of Sport Sciences and Physical Education, University of Coimbra, Estádio Universitário, Pavilhão 3, 3040 156 Coimbra, Portugal
    Cardiovasc Diabetol 11:13. 2012
    ..Age is associated with several risk factors as increased body fat and abdominal fat, deterioration of the lipid profile, diabetes, raising in inflammatory activity, or decreased functional fitness...
  90. pmc Relationship between urinary bisphenol A levels and diabetes mellitus
    Anoop Shankar
    Department of Community Medicine, West Virginia University School of Medicine, P O Box 9190, Morgantown, West Virginia 26506 9190, USA
    J Clin Endocrinol Metab 96:3822-6. 2011
    ..However, few human studies have examined the association between markers of BPA exposure and diabetes mellitus.
  91. ncbi Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver
    E D Abel
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 409:729-33. 2001
    ..G4A-/- mice develop glucose intolerance and hyperinsulinaemia. Thus, downregulation of GLUT4 and glucose transport selectively in adipose tissue can cause insulin resistance and thereby increase the risk of developing diabetes...
  92. pmc Exposure to arsenic in drinking water is associated with increased prevalence of diabetes: a cross-sectional study in the Zimapán and Lagunera regions in Mexico
    Luz M Del Razo
    Departamento de Toxicologia, Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, Mexico DF, Mexico
    Environ Health 10:73. 2011
    Human exposures to inorganic arsenic (iAs) have been linked to an increased risk of diabetes mellitus. Recent laboratory studies showed that methylated trivalent metabolites of iAs may play key roles in the diabetogenic effects of iAs...
  93. pmc Diabetes, glycemic control, and risk of hospitalization with pneumonia: a population-based case-control study
    Jette B Kornum
    Department of Clinical Epidemiology, Aarhus University Hospital, Aalborg, Denmark
    Diabetes Care 31:1541-5. 2008
    ..To examine whether diabetes is a risk factor for hospitalization with pneumonia and to assess the impact of A1C level on such risk...
  94. pmc Increased risk of diabetes and polychlorinated biphenyls and dioxins: a 24-year follow-up study of the Yucheng cohort
    Shu Li Wang
    Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Miaoli, Taiwan
    Diabetes Care 31:1574-9. 2008
    ..We aimed to examine the association between previous high exposures to PCBs and PCDFs and the cumulative incidence of type 2 diabetes and hypertension...
  95. ncbi Decreased cardiac expression of vascular endothelial growth factor and its receptors in insulin-resistant and diabetic States: a possible explanation for impaired collateral formation in cardiac tissue
    Eva Chou
    Research Division, Beetham Eye Institute, Joslin Diabetes Center, Boston, Massachusetts, USA
    Circulation 105:373-9. 2002
    ..Insulin treatment of diabetic rats normalized changes in both cardiac and microvascular tissues. Insulin increased VEGF mRNA expression in cultured rat neonatal cardiac myocytes...
  96. doi Diabetes blockade of sevoflurane postconditioning is not restored by insulin in the rat heart: phosphorylated signal transducer and activator of transcription 3- and phosphatidylinositol 3-kinase-mediated inhibition
    Benjamin Drenger
    Department of Anesthesiology and Critical Care Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Anesthesiology 114:1364-72. 2011
    ..To determine whether postC cardioprotection can be restored by normoglycemia, we treated rats with insulin...
  97. ncbi Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition
    Scott M Grundy
    Circulation 109:433-8. 2004
  98. ncbi Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001
    Ali H Mokdad
    Division of Adult and Community Health, 4770 National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341 3717, USA
    JAMA 289:76-9. 2003
    ..Obesity and diabetes are increasing in the United States...
  99. ncbi International comparison of the relationship of chronic kidney disease prevalence and ESRD risk
    Stein I Hallan
    Department of Medicine, Division of Nephrology, St Olav University Hospital, N 7006 Trondheim, Norway
    J Am Soc Nephrol 17:2275-84. 2006
    ..In conclusion, CKD prevalence in Norway was similar to that in the United States, suggesting that lower progression to ESRD rather than a smaller pool of individuals at risk accounts for the lower incidence of ESRD in Norway...
  100. doi Urban rural differences in prevalence of self-reported diabetes in India--the WHO-ICMR Indian NCD risk factor surveillance
    Viswanathan Mohan
    Madras Diabetes Research Foundation and Dr Mohan s Diabetes Specialities Centre, 4 Conran Smith Road, Gopalapuram, Chennai 600086, India
    Diabetes Res Clin Pract 80:159-68. 2008
    ..Urban residence, abdominal obesity and physical inactivity are the risk factors associated with diabetes in this study...
  101. pmc Molecular diagnosis of neonatal diabetes mellitus using next-generation sequencing of the whole exome
    Amelie Bonnefond
    CNRS UMR 8199, Univ Lille Nord de France, UDSL, Lille, France
    PLoS ONE 5:e13630. 2010
    Accurate molecular diagnosis of monogenic non-autoimmune neonatal diabetes mellitus (NDM) is critical for patient care, as patients carrying a mutation in KCNJ11 or ABCC8 can be treated by oral sulfonylurea drugs instead of insulin ..

Research Grants80

  1. Pyruvate Dehydrogenase kinase as Therapeutic Target for Hepatic Steatosis, Obesit
    Robert A Harris; Fiscal Year: 2012
    ..27,000 Americans die each year from cirrhosis. Hepatic steatosis, obesity, insulin resistance, and type 2 diabetes mellitus are all closely linked [64]...
  2. Correction of glutathione deficiency for treatment of diabetic nephropathy
    Paolo Fanti; Fiscal Year: 2013
    ..production and low disposal of toxic pro-oxidant chemicals, and it is very common in patients with Type 2 Diabetes Mellitus (T2DM) and diabetic kidney disease...
  3. Effects of Evoked Resistance Training and Testosterone after Spinal Cord Injury
    Ashraf Gorgey; Fiscal Year: 2012
    ..for the deterioration in body composition and metabolic profiles and leads to increase obesity, type 2 diabetes mellitus, dyslipidemia and subsequently cardiovascular disease...
  4. Ang II and Overnutrition and Insulin resistance in Cardiovascular Tissue
    JAMES RUSSELL SOWERS; Fiscal Year: 2013
    ..metabolic actions of insulin is often present in persons with hypertension and is a precursor for type 2 diabetes mellitus and cardiovascular disease...
  5. MOLECULAR BASIS OF INSULIN RESISTANCE
    Maureen J Charron; Fiscal Year: 2010
    The incidence of Type 2 diabetes mellitus (T2DM) and the Metabolic Syndrome has reached epidemic proportions. Human and rodent studies provide strong support for a genetic predisposition to these pathologies...
  6. Iron, Metabolic Regulation and Type 2 Diabetes Risk
    Donald A McClain; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): High iron levels in blood and tissues are a risk factor for diabetes mellitus. This is true not only for well- described conditions of iron overload such as hereditary hemochromatosis (HH) but even ..
  7. Pathobiology of Cystic Fibrosis-Related Diabetes in a Ferret Model
    Zoe Stewart; Fiscal Year: 2013
    ..In CF patients, pancreatic disease leads to diabetes mellitus in up to 50% of adult patients, resulting in reduced life expectancy...
  8. REGULATION OF GENE EXPRESSION BY DIETARY FAT
    Lisa M Salati; Fiscal Year: 2012
    ..that eating the majority of calories as fat results in the development of insulin resistance and type II diabetes mellitus. Much less is known about how non-pathological fluctuations in dietary fat intake alter intracellular ..
  9. Oklahoma Autoimmunity Center of Excellence
    Judith A James; Fiscal Year: 2013
    ..multiple sclerosis, Sj"gren's syndrome, thrombotic thrombocytopenic purpura, insulin dependent diabetes mellitus, pediatric SLE and juvenile inflammatory arthritis to forward translational research in autoimmunity...
  10. INSULIN RECEPTORS AND THE GLUCOSE TRANSPORT SYSTEM
    JERROLD MICHAEL OLEFSKY; Fiscal Year: 2013
    ..These studies should lead to an improved understanding of the basic causes of Type 2 diabetes mellitus and hold the potential for new therapeutic modalities.
  11. Regulation of microRNA-375 by cyclic-AMP in pancreatic beta-cells
    DAVID MATTHEW KELLER; Fiscal Year: 2010
    ..For this reason, the cAMP signaling pathway is currently being targeted by therapeutics for type 2 diabetes mellitus (Drucker and Nauck, 2006)...
  12. Studying the effects of vitamin D on FOXP3 and IL-17 expression in human CD4+ T c
    Insoo Kang; Fiscal Year: 2010
    ..with autoimmune diseases including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), type I diabetes mellitus (DM) and multiple sclerosis (MS)...
  13. ALTERED CARDIAC MYOCYTE SIGNALING IN DIABETIC MYOCARDIUM AND FUNCTIONAL SEQUELAE
    ANTHONY JUSTIN MUSLIN; Fiscal Year: 2010
    b>Diabetes mellitus is associated with a cardiomyopathy that occurs in the absence of hypertension or coronary artery disease and that is characterized by ventricular hypertrophy, decreased ventricular diastolic relaxation, and a reduced ..
  14. Surgical amelioration of type 2 diabetes: Hormones, microbiota and mitochondria
    PETER J contact HAVEL; Fiscal Year: 2010
    ..With the increased prevalence to type-2 diabetes mellitus (T2DM), new strategies for diabetes prevention are needed...
  15. NITROGEN HETEROCYCLES: METABOLIC EFFECTS AND TOXICITY
    Raymond F Novak; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Diabetes Mellitus (DM) increases the risk of developing chronic non-alcoholic liver disease, non-alcoholic steatohepatitis, and hepatocellular carcinoma...
  16. A2b Adenosine Receptor Regulation of Metabolic Disease and Inflammation
    Anna Eisenstein; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Type II diabetes mellitus (T2D) is a major risk factor for multiple diseases and a significant contributor to morbidity and mortality in the United States T2D is defined by an inability of the body ..
  17. Preclinical drug trial in mouse models of inflammation
    Kanneboyina Nagaraju; Fiscal Year: 2011
    ..is that these desired anti-inflammatory effects are generally accompanied by drastic side effects such as diabetes mellitus, peptic ulcer, Cushing's syndrome, osteoporosis, skin atrophy, psychosis, glaucoma, and many others ..
  18. N-Acetylcysteine and Milk Thistle for Treatment of Diabetic Nephropathy
    Paolo Fanti; Fiscal Year: 2011
    ..of oxidative stress and inflammation, which are characteristically observed in patients with type 2 diabetes mellitus (T2DM) and related nephropathy...
  19. Improved Adventitial Sirolimus Therapy for Peripheral Artery Restenosis
    KIRK SEWARD; Fiscal Year: 2010
    ..of Western societies include an aging population with a near epidemic of obesity, insulin resistance, and diabetes mellitus, causing a dramatic rise in the prevalence of PAD, which impairs the ability to walk and causes pain, ..
  20. PET Imaging of Myocardial Oxidative Stress in T2DM
    KOORESH ISAAC SHOGHI; Fiscal Year: 2013
    ..pathogenesis of a wide range of diseases such as cancer, neurocognitive and neurodenerative disorders, and diabetes mellitus. Moreover, oxidative stress secondary to increased ROS is central to pathogenesis various cardiovascular ..
  21. Obesity: neural control of body weight and metabolism
    Barry E Levin; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Obesity and its related morbities of type 2 diabetes mellitus and hypertension have reached epidemic proportions in adults and children in the United States...
  22. Atypical PKC Knockout Models: Effect on Glucose and Lipid Homeostasis
    Robert V Farese; Fiscal Year: 2013
    ..e., a "metabolic syndrome" (MS), and ultimately type 2 diabetes mellitus (T2DM)...
  23. A Culturally Tailored LIfestyle Intervention to Prevent Diabetes in South Asians:
    KABAYAM M VENKAT NARAYAN; Fiscal Year: 2010
    ..South Asians, a rapidly growing segment of the US population, have significantly higher rates of Type 2 Diabetes Mellitus (T2DM), get T2DM at younger ages, and do worse health-wise once they have T2DM than the general population...
  24. Transcriptional Regulation of Natriuetic Sensitivity in Diabetes Mellitus
    PATIENCE O OBIH; Fiscal Year: 2012
    ..b>Diabetes mellitus is a metabolic disorder characterized by hyperglycemia and is associated with abnormalities in carbohydrate, ..
  25. IRON REGULATION OF GENE EXPRESSION
    ELIZABETH ANN LEIBOLD; Fiscal Year: 2013
    ..In humans, cellular iron overload can result in diabetes mellitus and neurodegenerative disease, and is associated with an increased risk of cancer, while iron deficiency ..
  26. Impact of Diabetes and Hyperlipidemia on Host Defense
    Hardy Kornfeld; Fiscal Year: 2013
    ..provided by applicant): We are studying the basis for increased tuberculosis (TB) susceptibility in diabetes mellitus (DM). The global population-attributable TB risk conferred by DM equals that of HIV/AIDS...
  27. Na+/H+-exchanger-1 and Diabetic Neuropathy
    MARK ANTHONY YOREK; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Peripheral diabetic neuropathy (PDN) is the most devastating complication of diabetes mellitus, and a leading cause of foot amputation...
  28. Protein alterations in skeletal muscle cells with improved mtDNA repair
    Lyudmila I Rachek; Fiscal Year: 2010
    ..muscular free fatty acids (FFA) accumulation might be responsible for mitochondrial dysfunction in type 2 diabetes mellitus (T2DM)...
  29. Mechanisms of Diabetic Hyperphagia and Insulin Resistance
    Michael W Schwartz; Fiscal Year: 2012
    ..provided by applicant): Both behavioral and metabolic consequences of uncontrolled, insulin-deficient diabetes mellitus (uDM) arise in part from the response of key brain areas such as the hypothalamic arcuate nucleus (ARC) and ..
  30. Effects of periodontitis on insulin target organs and glucose homeostasis
    Keiko Watanabe; Fiscal Year: 2013
    ..Epidemiological and clinical studies have established an association between periodontitis and Type 2 Diabetes Mellitus (T2DM)/obesity. However, the causality and mechanisms linking periodontitis to T2DM are not known...
  31. 5500 QTRAP
    John W Turk; Fiscal Year: 2010
    ..and analysis of complex lipid molecules relevant to the pathogenesis of metabolic diseases such as diabetes mellitus and its complications, to HIV/AIDS, to neurophysiologic research, and to characterizing components of cell ..
  32. Improving Hmong Health through Community Based Participatory Research
    DIAN LORENE BAKER; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The U.S. Hmong population experiences Type 2 diabetes mellitus (T2DM) at disproportionate rates when compared to Non-Hispanic whites (24 percent vs. 10.2 percent)...
  33. Oxidative Stress in Chronic Kidney Disease
    Talat Alp Ikizler; Fiscal Year: 2012
    ..metabolic disturbances that amplify the risks of cardiovascular disease and premature death independent of diabetes mellitus, hypertension, or other traditional cardiovascular risk factors exemplified in the Framingham Study...
  34. The Role of Circadian Periodicity in Human Cardiovascular Disease and Diabetes
    John P Forman; Fiscal Year: 2013
    ..in cross- sectional studies;furthermore, polymorphisms in the melatonin receptors are associated with type 2 diabetes mellitus (T2DM)...
  35. Hyperglycemia and Pregnancy Outcome(HAPO)Follow Up Study
    Boyd E Metzger; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Offspring of mothers with pre-existing diabetes mellitus (DM) or gestational DM (GDM) have an increased risk of childhood obesity. GDM is also associated with an increased maternal risk of type 2 DM...
  36. Beta-cell Proliferation
    Fredric E Wondisford; Fiscal Year: 2013
    ..Inability of adequate [unreadable]-cell response to metabolic challenges results in hyperglycemia and frank diabetes mellitus. The incretin hormone glucagon-like peptide-1 (GLP-1) stimulates murine pancreatic [unreadable]-cell ..
  37. Preclinical drug trial in mouse models of inflammation
    Kanneboyina Nagaraju; Fiscal Year: 2013
    ..is that these desired anti-inflammatory effects are generally accompanied by drastic side effects such as diabetes mellitus, peptic ulcer, Cushing's syndrome, osteoporosis, skin atrophy, psychosis, glaucoma, and many others ..
  38. Role of Oxidative Stress in Post-MI Cardiac Failure Associated with Diabetes
    MICHAEL FREDERICK HILL; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Patients with Diabetes Mellitus (DM) have a higher incidence of death after myocardial infarction (MI) than do non-diabetic patients...
  39. Characterization of an essential mitochondrial rRNA methyltransferase
    Kip E Guja; Fiscal Year: 2013
    ..Other TFB1M polymorphisms are associated with reduced insulin secretion and increased risk of type II diabetes mellitus, further highlightin the importance of this modification for normal mitochondrial function...
  40. Nitric Oxide and gastric motility in female diabetics
    Pandu R Gangula; Fiscal Year: 2010
    ..b>Diabetes mellitus is a chronic progressive disease that affects 16 million Americans...
  41. Metabolic Crosstalk Between Immune Cells and the Liver in Obesity
    BENJAMIN MANTELL; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Obesity and type 2 diabetes mellitus (T2DM) are two devastating diseases that are growing in prevalence to epidemic proportions...
  42. Genome-wide DNA Methylation Profiles Associated with Abnormal Intrauterine Growth
    Cristina Montagna; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Type 2 diabetes mellitus (T2DM) is an example of a major age-related disease that has risen dramatically in adults in the last two decades(1)...
  43. Role of SIRT3 in fetal programming and kidney dysfunction
    Karen R Jonscher; Fiscal Year: 2013
    ..whose lab investigates metabolic and genetic causes and consequences of maternal obesity and gestational diabetes mellitus (GDM) on the early developmental origins of obesity;co- mentor Dr...
  44. Protein Modifications and Unfolded Protein Response in Diabetic Embryopathy
    Zhiyong Zhao; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Diabetes mellitus in early pregnancy causes birth defects, even when perinatal care is available...
  45. Nonenzymatic glycation, bone quality, and microdamage in type 2 diabetic bone
    Eve Donnelly; Fiscal Year: 2013
    ..Research: Individuals with type 2 diabetes mellitus (T2DM) paradoxically have increased fracture risk despite normal or greater bone mineral density relative to ..
  46. Maternal Obesity and Gestational Diabetes: Impact on Metabolome
    William L Lowe; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Offspring of mothers with obesity and/or pre-existing or gestational diabetes mellitus (GDM) during pregnancy are at increased risk for obesity and altered glucose metabolism as children and adults, ..
  47. Hepatic Lipase and HCV Infection
    Tianyi Wang; Fiscal Year: 2010
    ..liver (steatosis) in patients, which may account for many metabolic disorders such as insulin resistance and diabetes mellitus. Combination therapy with polyethylene glycol modified IFN-a and ribavirin suppresses HCV replication in 40-..
  48. Autoimmunity Center of Excellence - Rochester
    R John Looney; Fiscal Year: 2013
    ..systemic lupus erythematosus, rheumatoid arthritis, Sjogren's syndrome, multiple sclerosis, and type I diabetes mellitus. We have well established clinical trials programs and large patient populations for each of these diseases...
  49. The role of SIRT1/FOXO4 pathway in podocyte apoptosis of diabetes mellitus
    PETER YENLUNG CHUANG; Fiscal Year: 2013
    ..This study could give new insight into the pathogenesis of diabetic nephropathy and provide targets for novel therapy. ..
  50. Fatty Acid Defects &Oxidative Stress Modulate Islet Function in Cystic Fibrosis
    Aliye Uc; Fiscal Year: 2013
    ..fatty acid perturbations have well-established roles in the pathophysiology of lung disease in CF and type 2 diabetes mellitus, but have not been studied in CFRD...
  51. K-Channels in Lymphocyte Function and Autoimmunity
    GEORGE KANIANTHARA CHANDY; Fiscal Year: 2012
    ..Disease-associated autoreactive T cells in patients with multiple sclerosis (MS), type-1 diabetes mellitus (T1DM) and rheumatoid arthritis (RA) are TEM cells with elevated expression of Kv1.3 channels...
  52. Synergistic Roles of Adiponectin & PPARgamma in Beta-Cell Survival/Proliferation
    William L Holland; Fiscal Year: 2010
    ..b>Diabetes mellitus results from insulin availability that is insufficient to meet tissue insulin needs, and recent studies ..
  53. PERIPHERAL AND CENTRAL INTERACTIONS IN ENERGY BALANCE
    Barbara B Kahn; Fiscal Year: 2010
    ..Obesity and related disorders such as Type 2 diabetes mellitus are major healthcare issues in the United States, and decreasing their incidence in adults and children ..
  54. In vitro Type Two Diabetes Mellitus Tissue Model to Investigate Insulin Resistanc
    KELLY ANNE BURKE; Fiscal Year: 2013
    ..The goal in the present proposal is to develop a physiologically-relevant 3D tissue system for type two diabetes mellitus (T2DM), a disease state hallmarked by insulin resistance...
  55. Progesterone's Role in Pubertal Maturation in Normal and Hyperandrogenemic Adoles
    JESSICAH S P COLLINS; Fiscal Year: 2011
    ..cycles and infertility and causes an increased risk for obesity, the metabolic syndrome, and type 2 diabetes mellitus. Although PCOS is common and associated with significant morbidity, the etiology remains unknown...
  56. Endogenous Aldosterone and Glucose Homeostasis
    JAMES MATTHEW LUTHER; Fiscal Year: 2013
    ..They also reduce the incidence of type 2 Diabetes Mellitus (T2DM) in retrospective analyses of clinical trials...
  57. Growth Factor and Antiapoptotic Gene Delivery to Human Islets
    Ram I Mahato; Fiscal Year: 2012
    ..Transplantation of human islets has great potential as an effective means of treating insulin dependent diabetes mellitus. Primary non-function is the main cause of islet graft failure and it results in the need for multi-donor ..
  58. Matrix Otopathology
    MICHAEL ANNE NMI GRATTON; Fiscal Year: 2011
    ..Nevertheless, animal models of diabetes mellitus, systemic lupus erythematosus, presbycusis, and Alport's syndrome exhibit abnormally thick strial ..
  59. Dysfunctional PGC-1alpha expression in skeletal muscle during diabetes
    S Russ Price; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Skeletal muscle atrophy is a frequent co-morbidity of diabetes mellitus (DM) and other chronic diseases that causes fatigue and weakness...
  60. Tunable Insulin Resistance in a Drosophila Model of Diabetes
    ELENA M GRACHEVA; Fiscal Year: 2010
    ..at Washington University, regarding a diet-induced Drosophila model system for insulin resistance and Type-2 diabetes mellitus (T2DM)...
  61. A PROOF-OF-CONCEPT CLINICAL TRIAL OF XENIN-25 IN THE TREATMENT OF TYPE 2 DIABETES
    Burton M Wice; Fiscal Year: 2010
    ..Type 2 diabetes mellitus (T2DM) is the commonest form of diabetes accounting for well over 80% of cases...
  62. INSULIN ACTION IN MUSCLE AND FAT CELLS
    JAMES CARLTON GARRISON; Fiscal Year: 2010
    ..A defect in the ability of these cells to respond to insulin is a primary cause of Type 2 diabetes mellitus, which in turn is a leading cause of vision disorders, neuropathy, kidney disease, peripheral vascular ..
  63. Epigenomic Regulation of Gene Expression in Diet Induced Obesity
    Donald K Scott; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Obesity and its related disorders, including type 2 diabetes mellitus, metabolic syndrome, and cardiovascular disease, have reached epidemic levels in the United States...
  64. North Lawndale Diabetes Community Action Project
    STEVEN contact WHITMAN; Fiscal Year: 2010
    ..5 among persons with type 2 diabetes mellitus living in a medically underserved urban neighborhood...
  65. PET Imaging Agent for Diabetes Mellitus
    JOGESH MUKHERJEE; Fiscal Year: 2010
    ..This results in diabetes mellitus (DM), type 1 (TIDM) or type 2 (T2DM)...
  66. Pig to Non-Human Primate Islet Xenografts
    Bernhard Hering; Fiscal Year: 2009
    ..islet transplantation provide proof of principle that cell-based diabetes therapy can reverse the course of diabetes mellitus. As demand for islet transplantation increases the human islet donor shortage precludes widespread ..
  67. Glucose monitoring using polarized light
    Gerard L Cote; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Diabetes mellitus is a chronic disease that requires daily management to prevent large fluctuations in blood glucose levels and Diabetes disease management as well as biomedical sensor development is ..
  68. The Magnesium and Metabolic Syndrome Trial
    Stella Lucia Volpe; Fiscal Year: 2010
    ..with the metabolic syndrome could improve insulin sensitivity and prevent or delay the onset of type 2 diabetes mellitus and its complications...
  69. Mechanism of Arsenic-Induced Diabetes
    Miroslav Styblo; Fiscal Year: 2002
    DESCRIPTION (provided by applicant) This project examines the role of arsenicals in the induction of diabetes mellitus. Inorganic forms of arsenic (iAs) are highly toxic and are classified as human carcinogens...
  70. DIABETES WELLNESS--AMERICAN INDIAN TALKING CIRCLES
    Felicia Hodge; Fiscal Year: 2001
    DESCRIPTION (Adapted from the Investigator's Abstract): Non-insulin Dependent Diabetes Mellitus NIDDM), or Type II Diabetes, has reached epidemic proportions among American Indians throughout North America...
  71. DIABETIC NEUROPATHIC FOOT ULCER: WHO WILL HEAL?
    David Margolis; Fiscal Year: 2003
    DESCRIPTION (adapted from the application) Lower extremity ulcers are a serious complication of diabetes mellitus. More than 16 million people in the US have diabetes mellitus and 15% of them can expect to develop a foot ulcer at some ..
  72. Targeting Inflammation to Improve Endothelial Function in Type 2 Diabetes: A Subs
    Mark A Creager; Fiscal Year: 2010
    ..provided by applicant): Atherosclerosis is the principal cause of death and disability in patients with diabetes mellitus. Diabetes exerts its pro-atherogenic actions, at least in part, by disturbing endothelial homeostasis...
  73. DIABETES MELLITUS & ISLET AMYLOID POLYPEPTIDE (IAAP)
    Kenneth Johnson; Fiscal Year: 1991
    ..amyloid polypeptide (IAPP) was recently purified from islet amyloid (IA) of cats and humans with TYPE 2 diabetes mellitus (DM)...
  74. OBESITY, GLUCOSE METABOLISM AND DIET IN OLDER WOMEN
    ALICE RYAN; Fiscal Year: 2001
    ..Research: Gestational diabetes mellitus (GDM) affects 90,000 women per yr in the U.S...
  75. Prevention of Type I Diabetes Mellitus using a Cell Vac*
    Nick Giannoukakis; Fiscal Year: 2002
    Type I diabetes mellitus is an autoimmune disease whose etiopathogenesis lies in the selective destruction of the insulin-producing beta cells of the islets of Langerhans in the pancreas...
  76. A pilot study of moderate hyperbilirubinemia in type 1 diabetes mellitus
    Todd Perlstein; Fiscal Year: 2011
    ..strategy of inducing moderate hyperbilirubinemia for preventing the vascular complications of type 1 diabetes mellitus (T1DM)...
  77. MECHANISMS UNDERLYING CARDIOVASCULAR RISKS IN DIABETES
    Gordon Williams; Fiscal Year: 2000
    The overall hypothesis to be tested in this investigation is that in diabetes mellitus (DM), it is hyperinsulinemia and hyperglycemia in combination with differences in the specific alleles of the genes of the renin-angiotensin and PAI-1 ..
  78. Markers of the metabolic syndrome linking type 2 diabetes and MI in South Asia
    Danish Saleheen; Fiscal Year: 2010
    ..Area (04) and specific Challenge Topic, 04-TW-101: "Examining the clinical and mechanistic link between diabetes mellitus and cardiovascular disease in low- and middle-income countries...
  79. Treatment for Canine Diabetic Cataracts
    Milton Wyman; Fiscal Year: 2007
    ..In the 62 million companion dog population in the United States, there has been a three-fold increase in diabetes mellitus (DM) over the last 30 years...