cushing syndrome

Summary

Summary: A condition caused by prolonged exposure to excess levels of cortisol (HYDROCORTISONE) or other GLUCOCORTICOIDS from endogenous or exogenous sources. It is characterized by upper body OBESITY; OSTEOPOROSIS; HYPERTENSION; DIABETES MELLITUS; HIRSUTISM; AMENORRHEA; and excess body fluid. Endogenous Cushing syndrome or spontaneous hypercortisolism is divided into two groups, those due to an excess of ADRENOCORTICOTROPIN and those that are ACTH-independent.

Top Publications

  1. ncbi Diagnosis and complications of Cushing's syndrome: a consensus statement
    G Arnaldi
    Department of Internal Medicine, University of Ancona, 60100 Ancona, Italy
    J Clin Endocrinol Metab 88:5593-602. 2003
  2. ncbi Incidence and late prognosis of cushing's syndrome: a population-based study
    J Lindholm
    Department of Medicine, Holstebro Hospital, 7500 Holstebro, Denmark
    J Clin Endocrinol Metab 86:117-23. 2001
  3. ncbi Diabetes in Cushing syndrome: basic and clinical aspects
    Gherardo Mazziotti
    Department of Medical and Surgical Sciences University of Brescia, Endocrine Service, Montichiari Hospital, 25018, Brescia, Italy
    Trends Endocrinol Metab 22:499-506. 2011
  4. ncbi Evaluation of health-related quality of life in patients with Cushing's syndrome with a new questionnaire
    S M Webb
    Department of Endocrinology, Hospital Sant Pau, Centre for Biomedical Research on Rare Diseases CIBERER Unit 747, Autonomous University of Barcelona, Pare Claret 167, 08025 Barcelona, Spain
    Eur J Endocrinol 158:623-30. 2008
  5. ncbi Recommended evaluation of adrenal incidentalomas is costly, has high false-positive rates and confers a risk of fatal cancer that is similar to the risk of the adrenal lesion becoming malignant; time for a rethink?
    T J Cawood
    Department of Endocrinology, Christchurch Hospital, Private Bag 4710, Christchurch, New Zealand
    Eur J Endocrinol 161:513-27. 2009
  6. ncbi The European Registry on Cushing's syndrome: 2-year experience. Baseline demographic and clinical characteristics
    Elena Valassi
    IIB Sant Pau and Department of Endocrinology Medicine, Hospital Sant Pau, UAB and Centro de Investigación Biomédica en Red de Enfermedades Raras CIBER ER, Unidad 747, ISCIII Pare Claret 167, 08025 Barcelona, Spain
    Eur J Endocrinol 165:383-92. 2011
  7. ncbi Negative illness perceptions are associated with impaired quality of life in patients after long-term remission of Cushing's syndrome
    Jitske Tiemensma
    Department of Endocrinology and Metabolism, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Eur J Endocrinol 165:527-35. 2011
  8. pmc Cushing syndrome in pediatrics
    Constantine A Stratakis
    Section on Endocrinology and Genetics, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1862, USA
    Endocrinol Metab Clin North Am 41:793-803. 2012
  9. ncbi Surgical versus conservative management for subclinical Cushing syndrome in adrenal incidentalomas: a prospective randomized study
    Antonio Toniato
    Surgical Pathology Clinic, Department of Medical and Surgical Sciences, University of Padua School of Medicine, Padova, Italy
    Ann Surg 249:388-91. 2009
  10. ncbi Long-term impaired quality of life in Cushing's syndrome despite initial improvement after surgical remission
    John R Lindsay
    Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Building 10, Clinical Research Center, Room 1 3140, 10 Center Drive, Bethesda, MD 20892 1109, USA
    J Clin Endocrinol Metab 91:447-53. 2006

Detail Information

Publications260 found, 100 shown here

  1. ncbi Diagnosis and complications of Cushing's syndrome: a consensus statement
    G Arnaldi
    Department of Internal Medicine, University of Ancona, 60100 Ancona, Italy
    J Clin Endocrinol Metab 88:5593-602. 2003
    ..The consensus statement on diagnostic criteria and the diagnosis and treatment of complications of this syndrome reached at the workshop is hereby summarized...
  2. ncbi Incidence and late prognosis of cushing's syndrome: a population-based study
    J Lindholm
    Department of Medicine, Holstebro Hospital, 7500 Holstebro, Denmark
    J Clin Endocrinol Metab 86:117-23. 2001
    ....
  3. ncbi Diabetes in Cushing syndrome: basic and clinical aspects
    Gherardo Mazziotti
    Department of Medical and Surgical Sciences University of Brescia, Endocrine Service, Montichiari Hospital, 25018, Brescia, Italy
    Trends Endocrinol Metab 22:499-506. 2011
    Diabetes mellitus is a frequent complication of Cushing syndrome (CS) which is caused by chronic exposure to glucocorticoid excess, either endogenous or exogenous, and that is characterized by several clinical symptoms such as central ..
  4. ncbi Evaluation of health-related quality of life in patients with Cushing's syndrome with a new questionnaire
    S M Webb
    Department of Endocrinology, Hospital Sant Pau, Centre for Biomedical Research on Rare Diseases CIBERER Unit 747, Autonomous University of Barcelona, Pare Claret 167, 08025 Barcelona, Spain
    Eur J Endocrinol 158:623-30. 2008
    ..We have developed a disease-generated questionnaire to evaluate HRQoL in patients with Cushing's syndrome (CS; CushingQoL)...
  5. ncbi Recommended evaluation of adrenal incidentalomas is costly, has high false-positive rates and confers a risk of fatal cancer that is similar to the risk of the adrenal lesion becoming malignant; time for a rethink?
    T J Cawood
    Department of Endocrinology, Christchurch Hospital, Private Bag 4710, Christchurch, New Zealand
    Eur J Endocrinol 161:513-27. 2009
    ..Surgical series, histopathological series and oncological series were reviewed and most were excluded...
  6. ncbi The European Registry on Cushing's syndrome: 2-year experience. Baseline demographic and clinical characteristics
    Elena Valassi
    IIB Sant Pau and Department of Endocrinology Medicine, Hospital Sant Pau, UAB and Centro de Investigación Biomédica en Red de Enfermedades Raras CIBER ER, Unidad 747, ISCIII Pare Claret 167, 08025 Barcelona, Spain
    Eur J Endocrinol 165:383-92. 2011
    ..The European Registry on Cushing's syndrome (ERCUSYN) is designed to collect prospective and follow-up data at EU level on Cushing's syndrome (CS)...
  7. ncbi Negative illness perceptions are associated with impaired quality of life in patients after long-term remission of Cushing's syndrome
    Jitske Tiemensma
    Department of Endocrinology and Metabolism, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Eur J Endocrinol 165:527-35. 2011
    ..Therefore, the objective of this study was to explore illness perceptions, as potentially modifiable psychological factors, in relation to QoL in patients with long-term remission of CS...
  8. pmc Cushing syndrome in pediatrics
    Constantine A Stratakis
    Section on Endocrinology and Genetics, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1862, USA
    Endocrinol Metab Clin North Am 41:793-803. 2012
    b>Cushing syndrome is characterized by truncal obesity, growth deceleration, skin changes, muscle weakness, and hypertension. Cushing syndrome in childhood usually results from the exogenous administration of glucocorticoids...
  9. ncbi Surgical versus conservative management for subclinical Cushing syndrome in adrenal incidentalomas: a prospective randomized study
    Antonio Toniato
    Surgical Pathology Clinic, Department of Medical and Surgical Sciences, University of Padua School of Medicine, Padova, Italy
    Ann Surg 249:388-91. 2009
    To compare the clinical outcome of patients with subclinical Cushing syndrome (SCS) due to an adrenal incidentaloma (the autonomous hypersecretion of a small amount of cortisol, which is not enough to cause clinically-evident disease) who ..
  10. ncbi Long-term impaired quality of life in Cushing's syndrome despite initial improvement after surgical remission
    John R Lindsay
    Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Building 10, Clinical Research Center, Room 1 3140, 10 Center Drive, Bethesda, MD 20892 1109, USA
    J Clin Endocrinol Metab 91:447-53. 2006
    ..Cushing's syndrome (CS) is associated with symptoms that may impair health-related quality of life (HRQL)...
  11. ncbi Cardiovascular risk factors and common carotid artery caliber and stiffness in patients with Cushing's disease during active disease and 1 year after disease remission
    Antongiulio Faggiano
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Naples, Italy
    J Clin Endocrinol Metab 88:2527-33. 2003
    ..The persistence of a metabolic syndrome, vascular damage, and atherosclerotic plaques after cortisol level normalization makes these subjects still at high cardiovascular risk despite disease remission...
  12. ncbi An unusual case of ectopic ACTH syndrome
    M J Willhauck
    Department of Internal Medicine II of the Ludwig Maximilians University, Munich, Germany
    Exp Clin Endocrinol Diabetes 120:63-7. 2012
    ....
  13. ncbi Aberrant G-protein coupled receptor expression in relation to adrenocortical overfunction
    Andre Lacroix
    Division of Endocrinology, Department of Medicine, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Universite de Montreal, Montreal, QC, Canada
    Clin Endocrinol (Oxf) 73:1-15. 2010
    ....
  14. ncbi Psychosomatic aspects of Cushing's syndrome
    Nicoletta Sonino
    Department of Statistical Sciences, University of Padova, Via Battisti 241, 35121 Padova, Italy
    Rev Endocr Metab Disord 11:95-104. 2010
    ..Applying interdisciplinary expertise and addressing the needs for rehabilitation would markedly improve final outcome...
  15. ncbi Children experience cognitive decline despite reversal of brain atrophy one year after resolution of Cushing syndrome
    Deborah P Merke
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1932, USA
    J Clin Endocrinol Metab 90:2531-6. 2005
    Adults with Cushing syndrome frequently develop brain atrophy, memory impairment, and depression, with partial to complete resolution after cure...
  16. ncbi Management of diabetes mellitus in Cushing's syndrome
    Alia Munir
    Academic Unit of Diabetes and Endocrinology, University of Sheffield, Sheffield, UK
    Neuroendocrinology 92:82-5. 2010
    ..Despite resolution of Cushing's syndrome after definitive treatment patients may continue to exhibit insulin resistance. This and other cardiovascular risk factors require ongoing and long-term attention...
  17. ncbi Eutopic overexpression of vasopressin v1a receptor in adrenocorticotropin-independent macronodular adrenal hyperplasia
    Tomoatsu Mune
    Third Department of Internal Medicine, Gifu University School of Medicine, Gifu 500 8705, Japan
    J Clin Endocrinol Metab 87:5706-13. 2002
    ..Our results imply a possible association of V(1a) receptor expression with adrenal hyperplasia...
  18. ncbi Familial adrenocorticotropin-independent macronodular adrenal hyperplasia with aberrant serotonin and vasopressin adrenal receptors
    D Vezzosi
    Departments of Endocrinology and
    Eur J Endocrinol 156:21-31. 2007
    ....
  19. ncbi Epidemiology of Cushing's syndrome
    Charlotte Steffensen
    Medical Department M, Aarhus University Hospital, Aarhus, Denmark
    Neuroendocrinology 92:1-5. 2010
    ..Cushing's syndrome continues to pose diagnostic and therapeutic challenges and life-long follow-up is mandatory...
  20. ncbi Cushing's syndrome secondary to olfactory neuroblastoma
    M A Arnesen
    Department of Pathology, Abbott Northwestern Hospital, Minneapolis, Minnesota 55407
    Ultrastruct Pathol 18:61-8. 1994
    ..Electron microscopy revealed neuritic processes containing microtubules and neurosecretory granules. This is the first reported case of Cushing's syndrome secondary to olfactory neuroblastoma...
  21. ncbi Aberrant expression of multiple hormone receptors in ACTH-independent macronodular adrenal hyperplasia causing Cushing's syndrome
    J W B de Groot
    Department of Endocrinology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    Eur J Endocrinol 163:293-9. 2010
    ..We aimed to determine aberrant expression of multiple hormone receptors in vivo and in vitro in adrenal tissue of a patient with AIMAH...
  22. ncbi Diagnostic performance of salivary cortisol and serum osteocalcin measurements in patients with overt and subclinical Cushing's syndrome
    Marta Sereg
    2nd Department of Medicine, Semmelweis University, Szentkiralyi u 46, Budapest H 1088, Hungary
    Steroids 76:38-42. 2011
    ..Because serum osteocalcin (OC) is considered as a sensitive marker of hypercortisolism, we also investigated whether OC could have a role in the diagnosis of CS...
  23. pmc Cushing syndrome secondary to ectopic adrenocorticotropic hormone secretion: the University of Texas MD Anderson Cancer Center Experience
    Shamim Ejaz
    Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Cancer 117:4381-9. 2011
    b>Cushing syndrome (CS) secondary to ectopic adrenocorticotropic hormone (ACTH) secretion (EAS) has been described in association with a variety of tumors...
  24. ncbi Is metabolic syndrome a mild form of Cushing's syndrome?
    Armand Krikorian
    Division of Clinical and Molecular Endocrinology, Case Western Reserve University, Case Medical Center, 11100 Euclid Ave, Cleveland, OH 44106, USA
    Rev Endocr Metab Disord 11:141-5. 2010
    ..More research is needed to explore the relation between cortisol and the metabolic syndrome which, if confirmed, will have major therapeutic and public health implications...
  25. ncbi Coagulopathy in Cushing's syndrome
    Laura Trementino
    Division of Endocrinology, Department of Internal Medicine, Polytechnic University of Marche Region, Ancona, Italy
    Neuroendocrinology 92:55-9. 2010
    ..In the absence of prospective randomized trials, preventive antithrombotic treatment (best with heparin) during IPS sampling and low-dose heparin treatment early after surgery should be suggested...
  26. pmc The diagnosis of Cushing's syndrome: an Endocrine Society Clinical Practice Guideline
    Lynnette K Nieman
    Program on Reproductive and Adult Endocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Clin Endocrinol Metab 93:1526-40. 2008
    ..The objective of the study was to develop clinical practice guidelines for the diagnosis of Cushing's syndrome...
  27. ncbi Elevated plasma endothelin as an additional cardiovascular risk factor in patients with Cushing's syndrome
    G Kirilov
    Clinical Center of Endocrinology, Medical University, Sofia, Bulgaria
    Eur J Endocrinol 149:549-53. 2003
    ..Recently the pathophysiological role of endothelin (ET) has been presumed in a number of adrenal disorders such as primary hyperaldosteronism, pheochromocytoma and adrenocortical insufficiency...
  28. ncbi Effect of obesity and starvation on thyroid hormone, growth hormone, and cortisol secretion
    Liselle Douyon
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan Medical School, 1150 West Medical Center Dr, Ann Arbor, MI 48109, USA
    Endocrinol Metab Clin North Am 31:173-89. 2002
    ....
  29. ncbi Secondary diabetes associated with principal endocrinopathies: the impact of new treatment modalities
    Eugenia Resmini
    Department of Endocrinology and Medical Sciences, Center of Excellence for Biomedical Research, University of Genoa, Viale Benedetto XV, 6, 16132, Genoa, Italy
    Acta Diabetol 46:85-95. 2009
    ..tolerance (IGT) and overt diabetes mellitus are frequently associated with acromegaly and hypercortisolism (Cushing syndrome)...
  30. ncbi The diagnosis of Cushing's syndrome
    Ty B Carroll
    Endocrinology Center TBC, JWF, Medical College of Wisconsin, W129 N7055 Northfield Drive Building A, Suite 203, Menomonee Falls, WI 53051, USA
    Rev Endocr Metab Disord 11:147-53. 2010
    ..If this initial testing is abnormal, further evaluation should be directed by an endocrinologist experienced in the diagnosis and differential diagnosis of Cushing' syndrome...
  31. ncbi Quality of life after laparoscopic bilateral adrenalectomy for Cushing's disease
    Mary T Hawn
    Departments of Surgery and Internal Medicine, Oregon Health and Science University, Portland, OR, USA
    Surgery 132:1064-8; discussion 1068-9. 2002
    ..We examined surgical outcomes and quality of life after laparoscopic bilateral adrenalectomy for the treatment of Cushing's disease...
  32. ncbi Bilateral laparoscopic adrenalectomy for corticotrophin-dependent Cushing's syndrome: a review of the Mayo Clinic experience
    John T Chow
    Division of Endocrinology, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Clin Endocrinol (Oxf) 68:513-9. 2008
    ....
  33. ncbi The role of [(18)F]fluorodeoxyglucose positron emission tomography and [(111)In]-diethylenetriaminepentaacetate-D-Phe-pentetreotide scintigraphy in the localization of ectopic adrenocorticotropin-secreting tumors causing Cushing's syndrome
    Karel Pacak
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1583, USA
    J Clin Endocrinol Metab 89:2214-21. 2004
    ..As H-OCT identified a tumor in one patient with otherwise negative imaging, it should be considered only when other imaging modalities fail to localize the ACTH-secreting tumor in patients with EAS...
  34. ncbi Glucocorticoid resistance syndrome: A diagnostic and therapeutic approach
    Elisabeth F C van Rossum
    University Medical Center, Department of Internal Medicine Room D400, Erasmus Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Best Pract Res Clin Endocrinol Metab 20:611-26. 2006
    ..Diagnosis of generalized GC resistance can be difficult. This review highlights the diagnostic process and therapeutic options for treating patients with this disease...
  35. ncbi Hormones and cardiovascular disease: a shift in paradigm with clinical consequences?
    Bregje van Zaane
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Semin Thromb Hemost 35:478-87. 2009
    ..To date several new therapeutic approaches that focus on the control of hormones at the tissue level, independently of their circulating levels, are being developed. These may offer new possibilities for cardiovascular risk reduction...
  36. ncbi Radioimmunoassay and tandem mass spectrometry measurement of bedtime salivary cortisol levels: a comparison of assays to establish hypercortisolism
    Smita K Baid
    Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1109, USA
    J Clin Endocrinol Metab 92:3102-7. 2007
    ..Although bedtime salivary cortisol measurement has been proposed as the optimal screening test for the diagnosis of Cushing's syndrome, its performance using commercially available assays has not been widely evaluated...
  37. pmc Cushing's syndrome and fetal features resurgence in adrenal cortex-specific Prkar1a knockout mice
    Isabelle Sahut-Barnola
    CNRS UMR6247, Génétique Reproduction et Développement, Clermont Universite, Aubiere, France
    PLoS Genet 6:e1000980. 2010
    ..Furthermore, this model demonstrates that deregulated PKA activity favors the emergence of a new cell population potentially arising from the fetal adrenal, giving new insight into the mechanisms leading to PPNAD...
  38. ncbi Expression of serotonin7 receptor and coupling of ectopic receptors to protein kinase A and ionic currents in adrenocorticotropin-independent macronodular adrenal hyperplasia causing Cushing's syndrome
    Estelle Louiset
    Institut National de la Santé et de la Recherche Médicale INSERM Unité 413, Hospital of Boisguillaume, Centre Hospitalier Universitaire of Rouen, 76031 Rouen Cedex, France
    J Clin Endocrinol Metab 91:4578-86. 2006
    ..In ACTH-independent macronodular adrenal hyperplasia (AIMAH) causing Cushing's syndrome, cortisol secretion is controlled by illegitimate membrane receptors...
  39. ncbi Cushing's syndrome due to ectopic corticotropin secretion: twenty years' experience at the National Institutes of Health
    Ioannis Ilias
    Pediatric and Reproductive Endocrinology Branch, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1109, USA
    J Clin Endocrinol Metab 90:4955-62. 2005
    ..Ectopic ACTH secretion (EAS) is difficult to diagnose and treat. We present our experience with EAS from 1983 to 2004...
  40. ncbi Adrenal incidentaloma, clinical, metabolic, follow-up aspects: single centre experience
    Abdurrahman Comlekci
    Department of Internal Medicine, Division of Endocrinology and Metabolism, School of Medicine, Dokuz Eylul University, Inciralti, 35340 Izmir, Turkey
    Endocrine 37:40-6. 2010
    ..3 and 54.8%, respectively. Most of the adrenal adenomas were non-functioning (73.5%). Subclinical Cushing syndrome (sCS) was detected in 12.5%...
  41. ncbi Lysine vasopressin stimulation of cortisol secretion in patients with adrenocorticotropin-independent macronodular adrenal hyperplasia
    N Horiba
    Department of Medicine, Tokyo Women s Medical College, Japan
    J Clin Endocrinol Metab 80:2336-41. 1995
    ..The cortisol response to LVP may serve to facilitate their diagnosis and choice of therapy...
  42. ncbi Raised serum levels of interleukin-8 and interleukin-18 in relation to bone metabolism in endogenous Cushing's syndrome
    Cybele Kristo
    Section of Endocrinology, Medical Department, National University Hospital, N 0027 Oslo, Norway
    Eur J Endocrinol 146:389-95. 2002
    ....
  43. ncbi Pros and cons of screening for occult Cushing syndrome
    Antoine Tabarin
    Department of Endocrinology, Universite Bordeaux 2, Centre Hospitalier Universitaire de Bordeaux, France
    Nat Rev Endocrinol 7:445-55. 2011
    ..performed mainly in patients with diabetes mellitus have revealed an unexpectedly high prevalence of occult Cushing syndrome. Such studies may provide a rationale for systematically screening obese patients with type 2 diabetes ..
  44. ncbi Characterization and comparison of insulin resistance induced by Cushing Syndrome or diestrus against healthy control dogs as determined by euglycemic- hyperinsulinemic glucose clamp profile glucose infusion rate using an artificial pancreas apparatus
    Hiroko Fukuta
    Department of Veterinary Nursing and Technology, School of Veterinary Science, Nippon Veterinary and Life Science University, Tokyo, Japan
    J Vet Med Sci 74:1527-30. 2012
    ..The purpose of this study was to evaluate insulin resistance, induced either by Cushing Syndrome (CS) or diestrus in dogs, as determined by GIR by EHGC, using an artificial pancreas apparatus...
  45. pmc Quality of life and other outcomes in children treated for Cushing syndrome
    Margaret F Keil
    Section on Endocrinology Genetics, Program on Developmental Endocrinology Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 98:2667-78. 2013
    b>Cushing syndrome (CS) in children is associated with residual impairment in measures of health-related quality of life, even after successful resolution of hypercortisolemia, highlighting the need for early identification of morbidities ..
  46. ncbi [A case of Cushing syndrome presenting after pulmonary nocardiosis with pyothorax]
    Tomoaki Hoshino
    Division of Respirology, Neurology, and Rheumatology, Department of Medicine, Kurume University School of Medicine
    Nihon Kokyuki Gakkai Zasshi 47:746-50. 2009
    ..b>Cushing syndrome was diagnosed on the basis of tests including a low-dose dexamethasone suppression test...
  47. ncbi Hyperhomocysteinemia in patients with Cushing's syndrome
    Massimo Terzolo
    Dipartimento di Scienze Cliniche e Biologiche, Medicina Interna I, Universita di Torino, 10100 Torino, Italy
    J Clin Endocrinol Metab 89:3745-51. 2004
    ..Hyperhomocysteinemia may be key to the prothrombotic state and increased cardiovascular risk of Cushing's syndrome...
  48. ncbi Diagnostic errors after inferior petrosal sinus sampling
    Brooke Swearingen
    Neuroendocrine Clinical Center, Division of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 89:3752-63. 2004
    ....
  49. ncbi Long-term follow-up study of patients with adrenal incidentalomas
    Rossella Libe
    Institute of Endocrine Sciences, University of Milan, Ospedale Maggiore IRCCS, Milan, Italy
    Eur J Endocrinol 147:489-94. 2002
    ..Nonetheless, data concerning possible changes in adrenal size and/or hormonal pattern during follow-up are still inadequate...
  50. ncbi Overexpression of serotonin4 receptors in cisapride-responsive adrenocorticotropin-independent bilateral macronodular adrenal hyperplasia causing Cushing's syndrome
    Dorthe Cartier
    European Institute for Peptide Research, Laboratory of Cellular and Molecular Neuroendocrinology, INSERM U413, UA Centre National de la Recherche Scientifique, University of Rouen, Mont Saint Aignan, France
    J Clin Endocrinol Metab 88:248-54. 2003
    ..The enhanced sensitivity of these two tissues to 5-HT4 receptor agonists was not due to ectopic expression of 5-HT4 receptor isoforms or to the occurrence of somatic gain-of-function mutation of the receptor...
  51. ncbi Coexistence of Cushing syndrome from functional adrenal adenoma and Addison disease from immune-mediated adrenalitis
    Randall Colucci
    Appalachian Rural Health Institute Diabetes Endocrine Center, Ohio University Heritage College of Osteopathic Medicine, Castrop Center, Suite 200, Athens, OH 45701 2859, USA
    J Am Osteopath Assoc 112:374-9. 2012
    ..but normal serum morning cortisol and suppressed levels of corticotropin, suggestive of adrenal-dependent Cushing syndrome. The resected adrenal gland revealed macronodular cortical hyperplasia with a dominant nodule...
  52. ncbi Gene array analysis of macronodular adrenal hyperplasia confirms clinical heterogeneity and identifies several candidate genes as molecular mediators
    Isabelle Bourdeau
    Section on Endocrinology and Genetics, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Oncogene 23:1575-85. 2004
    ..Several candidate genes that may be responsible for AIMAH formation and/or progression were also identified, suggesting pathways that affect the cell cycle, adhesion and transcription as possible mediators of adrenocortical hyperplasia...
  53. ncbi Cushing's disease in childhood as the first manifestation of multiple endocrine neoplasia syndrome type 1
    M Rix
    Department of Paediatrics, Aalborg University Hospital, 9000 Aalborg, Denmark
    Eur J Endocrinol 151:709-15. 2004
    ..To describe three cases of Cushing's disease in children with multiple endocrine neoplasia type 1 (MEN1), as clinical manifestations of MEN1 are very rare in childhood...
  54. ncbi Case report: cushing disease caused by an ectopic intracavernous pituitary microadenoma: case report and review of the literature
    Michele Hamon
    Department of Neuroradiology and Interventional Radiology, Centre Hospitalo Universitaire, Caen, France
    J Comput Assist Tomogr 27:424-6. 2003
    ..We present a case of ACTH-dependent Cushing syndrome in which the demonstration of the cavernous sinus localization of a microadenoma was made by magnetic ..
  55. ncbi Aberrant cortisol regulations in bilateral macronodular adrenal hyperplasia: a frequent finding in a prospective study of 32 patients with overt or subclinical Cushing's syndrome
    Rossella Libe
    Department of Endocrinology, Metabolism and Cancer, Institut National de la Santé et de la Recherche Médicale Unité 567, Centre National de la Recherche Scientifique Unite Mixte de Recherche 8104, Institut Cochin, 75014 Paris, France
    Eur J Endocrinol 163:129-38. 2010
    ..ACTH-independent macronodular adrenal hyperplasia (AIMAH) is a rare and heterogeneous condition characterized by abnormal steroid production. Cortisol secretion can be regulated by aberrant hormone receptors...
  56. ncbi Deleterious effects of glucocorticoid replacement on bone in women after long-term remission of Cushing's syndrome
    María José Barahona
    Endocrinology Department, Hospital Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
    J Bone Miner Res 24:1841-6. 2009
    ..Thus, the additional deleterious effect of GC for the treatment of adrenal axis suppression should be considered...
  57. ncbi Familial vasopressin-sensitive ACTH-independent macronodular adrenal hyperplasia (VPs-AIMAH): clinical studies of three kindreds
    Lucia Gagliardi
    Endocrine and Metabolic Unit, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
    Clin Endocrinol (Oxf) 70:883-91. 2009
    ....
  58. ncbi Iatrogenic Cushing syndrome due to nasal steroid drops
    Veysel Nijat Baş
    Clinics of Pediatric Endocrinology, Dr Sami Ulus Research and Training Hospital of Women s and Children s Health and Diseases, Ankara, Turkey
    Eur J Pediatr 171:735-6. 2012
    Iatrogenic Cushing syndrome may occur as an undesirable outcome of high-dose glucocorticoids treatments. This may also cause hypothalamus-hypophysis-adrenal axis suppression...
  59. pmc Primary bimorphic adrenocortical disease: cause of hypercortisolism in McCune-Albright syndrome
    J Aidan Carney
    Department of Laboratory Medicine and Pathology, Division of Endocrinology, Diabetes, Nutrition and Metabolism, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Am J Surg Pathol 35:1311-26. 2011
    ..b>Cushing syndrome, a rare feature of the condition, usually affects infants and is the result of corticotropin-independent ..
  60. ncbi Case of adrenocorticotropic hormone-independent macronodular adrenal hyperplasia with possible adrenal hypersensitivity to angiotensin II
    Y Nakamura
    Department of Internal Medicine, Hyogo Prefectural Amagasaki Hospital, Japan
    Endocrine 15:57-61. 2001
    ..Bilateral laparoscopic adrenalectomy was performed. The histological findings of the specimen were compatible with AIMAH. In summary, we have made the first report on a case of AIMAH with possible hypersensitivity to angiotensin II...
  61. ncbi Mineralocorticoid and glucocorticoid receptors stimulate epithelial sodium channel activity in a mouse model of Cushing syndrome
    Matthew A Bailey
    Molecular Physiology Group, Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, United Kingdom
    Hypertension 54:890-6. 2009
    ..These data are relevant to conditions associated with overactivity of the hypothalamic-pituitary-adrenal axis, such as obesity and chronic stress...
  62. ncbi Food-dependent Cushing's syndrome
    C Messidoro
    Department of Internal Medicine, Sint Franciscus Gasthuis, Rotterdam, The Netherlands
    Neth J Med 67:187-90. 2009
    ..Identification of aberrant hormone receptor expression is of importance because it may create a possibility for pharmacological treatment...
  63. ncbi Aberrant expression of glucagon receptors in adrenal glands of a patient with Cushing's syndrome and ACTH-independent macronodular adrenal hyperplasia
    Valeria De Miguel
    Servicio de Endocrinologia, Metabolismo y Medicina Nuclear, Hospital Italiano de Buenos Aires, Argentina
    Medicina (B Aires) 70:254-6. 2010
    ..This is the first case reported of AIMAH associated with ectopic glucagon receptors...
  64. ncbi Biochemical basis for the hypercoagulable state seen in Cushing syndrome; discussion 1006-7
    R C Jacoby
    Department of Surgery, University of California-Davis, Medical Center, 2315 Stockton Blvd, Room 4209, Sacramento, CA 95817, USA
    Arch Surg 136:1003-6. 2001
    HYPOTHESIS: Cushing syndrome (CS) is associated with a hypercoagulable state that results in a 4-fold increase in the incidence of pulmonary embolism, deep venous thrombosis, and a 4-fold mortality rate compared with the general ..
  65. ncbi Olfactory neuroblastoma causing ectopic ACTH syndrome
    Kazuo Kanno
    Division of Endocrinology and Metabolism, Musashino Red Cross Hospital, Tokyo
    Endocr J 52:675-81. 2005
    ..Thus, this is the second rare case with ectopic ACTH syndrome caused by olfactory neuroblastoma thus far reported...
  66. ncbi A survey on adrenal incidentaloma in Italy. Study Group on Adrenal Tumors of the Italian Society of Endocrinology
    F Mantero
    Department of Internal Medicine, University of Ancona, Italy
    J Clin Endocrinol Metab 85:637-44. 2000
    ..0 cm because of the increased risk of malignancy, especially in young patients. Endocrine evaluation should be performed in all patients to identify silent states of hormone excess...
  67. ncbi The lethal form of Cushing's in 7B2 null mice is caused by multiple metabolic and hormonal abnormalities
    Miroslav S Sarac
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Endocrinology 143:2324-32. 2002
    ..A hypoglycemic crisis coupled with respiratory distress and intensive internal thrombosis most likely results in rapid deterioration and death of the 7B2 null...
  68. ncbi An aberrant ACTH-producing ectopic pituitary adenoma in the sphenoid sinus
    Jiro Suzuki
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Endocr J 51:97-103. 2004
    ..Although EAPA is clinically rare in parasellar disorders, the presence of ectopic pituitary adenoma should be considered in such cases showing ACTH hypersecretion without typical Cushingoid features...
  69. ncbi Cortisol and estradiol secretion by a benign virilizing adrenocortical tumor in a prepubertal girl
    Ali A M Ghazi
    Endocrine Research Center and Department of Internal Medicine, Beheshti University of Medical Sciences, Taleghani Hospital, Tehran, Iran
    J Pediatr Endocrinol Metab 17:235-8. 2004
    ..Hyperandrogenism can obscure the clinical features of Cushing's syndrome and estrogen hypersecretion in patients with functional adrenal tumors...
  70. ncbi Alcohol-induced Cushing syndrome. Hypercortisolism caused by alcohol abuse
    F Besemer
    Department of Internal Medicine and Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
    Neth J Med 69:318-23. 2011
    ..Alcoholism, however, can cause similar symptoms, giving rise to a so-called pseudo-Cushing state, which aggravates the differential diagnostic dilemmas of CS...
  71. ncbi The glucocorticoid-induced leucine zipper gene (GILZ) expression decreases after successful treatment of patients with endogenous Cushing's syndrome and may play a role in glucocorticoid-induced osteoporosis
    Tove Lekva
    Section of Endocrinology, Department of Medicine, Research Institute for Internal Medicine, Oslo University Hospital, Rikshospitalet, N 0027 Oslo, Norway
    J Clin Endocrinol Metab 95:246-55. 2010
    ..Glucocorticoid-induced bone loss is a serious complication in patients with endogenous Cushing's syndrome. However, the mechanism(s) by which excess glucocorticoids influence bone metabolism is not completely understood...
  72. ncbi Exogenous Cushing's syndrome due to topical corticosteroid application: case report and review literature
    Therdpong Tempark
    Division of Dermatology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand
    Endocrine 38:328-34. 2010
    ..At least 43 cases with iatrogenic Cushing syndrome from very potent topical steroid usage (Clobetasol) in children and adult have been published over the last ..
  73. ncbi Adrenal localization in the adrenocorticotropic hormone-independent Cushing syndrome
    L M Fig
    University of Michigan, Ann Arbor
    Ann Intern Med 109:547-53. 1988
    ..efficacy of 131I-6-beta-iodomethylnorcholesterol scintigraphy in the adrenocorticotropic hormone-independent Cushing syndrome and to compare this with computed tomography. DESIGN: Retrospective analysis of case series from 1977 to 1987...
  74. ncbi Multiple pulmonary atypical carcinoids presenting with long-standing Cushing syndrome masked by pulmonary tuberculosis
    Bo Gun Jang
    Department of Pathology and Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Pathol Int 59:399-404. 2009
    ..tumors, especially small cell carcinoma and typical carcinoids, are the most common cause of ectopic Cushing syndrome (CS)...
  75. ncbi Fatal liver failure due to ketoconazole treatment of a girl with Cushing's syndrome
    E Zollner
    Department of Paediatrics, University of Cape Town, South Africa
    J Pediatr Endocrinol Metab 14:335-8. 2001
    ..It is recommended that metyrapone be used when hypercortisolism has to be controlled as a temporary measure in childhood and adolescence...
  76. ncbi Infantile McCune-Albright syndrome
    J H Davies
    Department of Child Health, Royal Gwent Hospital, Newport, United Kingdom
    Pediatr Dermatol 18:504-6. 2001
    ..Following the clinical diagnosis of McCune-Albright syndrome, he was subsequently shown to have hypercortisolism and hyperthyroidism...
  77. ncbi Evaluation of the cardiovascular risk in patients with subclinical Cushing syndrome before and after surgery
    Yesim Erbil
    Department of General Surgery, Istanbul University, Istanbul Medical Faculty, 34340 Capa, Istanbul, Turkey
    World J Surg 30:1665-71. 2006
    ..Asymptomatic incidentally discovered adrenal masses may indicate that subclinical Cushing syndrome (SCS) is not uncommon...
  78. ncbi Inhaled fluticasone causes iatrogenic cushing's syndrome in patients treated with Ritonavir
    Keren Mahlab-Guri
    Clinical Immunology, Allergy and AIDS, Kaplan Medical Center, Rehovot, Israel
    J Asthma 48:860-3. 2011
    ..This may cause Cushing's syndrome (laboratory and clinical) with adrenal suppression...
  79. ncbi Iatrogenic Cushing's syndrome in HIV-infected patients receiving ritonavir and inhaled fluticasone: description of 4 new cases and review of the literature
    Nadia Valin
    Service de Maladies Infectieuses et Tropicales, APHP, Hopital Saint Louis, 75010 Paris, France
    J Int Assoc Physicians AIDS Care (Chic) 8:113-21. 2009
    ....
  80. pmc Cushing syndrome in the McCune-Albright syndrome
    Rebecca J Brown
    Clinical Endocrinology Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 4320, USA
    J Clin Endocrinol Metab 95:1508-15. 2010
    b>Cushing syndrome (CS) is a rare but potentially fatal feature of McCune-Albright syndrome (MAS). Optimal management, prognostic features, and long-term follow-up of this disorder have not been described.
  81. ncbi TXNIP is highly regulated in bone biopsies from patients with endogenous Cushing's syndrome and related to bone turnover
    Tove Lekva
    Section of Specialized Endocrinology, Department of Endocrinology, Faculty of Medicine, University of Oslo and Oslo University Hospital, 0027 Oslo, Norway
    Eur J Endocrinol 166:1039-48. 2012
    ..The aim of the present study was to investigate the functional role of TXNIP in bone with focus on osteoblast (OB) differentiation and OB-mediated osteoclast activity and function in vitro...
  82. ncbi Cushing syndrome due to ectopic adrenocorticotropic hormone secretion
    J P Aniszewski
    Division of Endocrinology, Metabolism, Nutrition, and Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    World J Surg 25:934-40. 2001
    b>Cushing syndrome (CS) caused by ectopic adrenocorticotropic hormone (ACTH) production (EA) poses major challenges diagnostically by mimicking the pituitary-dependent form of CS and therapeutically by producing severe, life-threatening ..
  83. ncbi 18F-DOPA PET/CT but not 68Ga-DOTA-TOC PET/CT revealed the underlying cause of ectopic Cushing syndrome
    Camilla Schalin-Jantti
    Division of Endocrinology, Department of Medicine, Helsinki University Central Hospital, PO Box 340, FI 00290 Helsinki, Finland
    Clin Nucl Med 37:904-5. 2012
    F-DOPA PET/CT but not Ga-DOTA-TOC PET/CT revealed the cause of ectopic Cushing syndrome in a 61-year-old man. The patient presented with rapid weight gain, swollen legs, and sleep disturbances. Plasma potassium level was 2...
  84. ncbi [Cushing syndrome with life-threatening infectious complications]
    S Kloehn
    Klinik für Allgemeine Innere Medizin, Christian Albrechts Universitat zu Kiel
    Dtsch Med Wochenschr 122:1547-52. 1997
    ..He had central cyanosis, ankle oedema, cushingoid appearance and ecchymoses. Loud rales ware heard over both lungs. Body temperature was 38.9 degrees C...
  85. pmc Laparoscopic adrenalectomy: pathologic features determine outcome
    Eric C Poulin
    Centre for Minimally Invasive Surgery, St Michael s Hospital, Toronto, Ont
    Can J Surg 46:340-4. 2003
    ..Therefore, we evaluated these outcomes in the 3 groups most often seen clinically: bilateral adrenalectomy for Cushing's disease (group 1), pheochromocytoma (group 2) and unilateral adrenalectomy for non-pheochromocytoma (group 3)...
  86. ncbi Strongyloides hyperinfection syndrome complicating (ectopic) Cushing syndrome
    Raja S Vadlamudi
    Section of General Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    South Med J 101:750-2. 2008
    ..a Strongyloides stercoralis hyperinfection syndrome complicating ectopic adrenocorticotropic hormone (Cushing syndrome)...
  87. ncbi Possibly simultaneous primary aldosteronism and preclinical Cushing's syndrome in a patient with double adenomas of right adrenal gland
    Takako Saito
    Department of Medicine, Jichi Medical University Omiya Medical Center, Japan
    Endocr J 54:287-93. 2007
    ....
  88. ncbi Coexistence of three distinct adrenal tumors in the same adrenal gland in a patient with primary aldosteronism and preclinical Cushing's syndrome
    Takafumi Okura
    The Second Department of Internal Medicine, Ehime University School of Medicine, Toon, Ehime 791 0295, Japan
    Clin Exp Nephrol 10:127-30. 2006
    ..Clinically and pathophysiologically, this was a very rare case...
  89. ncbi Cushing syndrome with secondary adrenal insufficiency from concomitant therapy with ritonavir and fluticasone
    Susan R Johnson
    Division of Infectious Diseases, Department of Pediatrics, University of South Florida College of Medicine, Tampa, 33606, USA
    J Pediatr 148:386-8. 2006
    We present 2 cases of Cushing syndrome with secondary adrenal insufficiency from concomitant use of ritonavir and inhaled corticosteroids in children with human immunodeficiency virus infection...
  90. ncbi Polymorphisms in von Willebrand factor gene promoter influence the glucocorticoid-induced increase in von Willebrand factor: the lesson learned from Cushing syndrome
    Alessandra Casonato
    Department of Medical and Surgical Sciences, Second Chair of Internal Medicine, University of Padua Medical School, Padua, Italy
    Br J Haematol 140:230-5. 2008
    b>Cushing syndrome (CS) features high-glucocorticoid secretion and an associated hypercoagulable state often involving an increase in von Willebrand factor (VWF)...
  91. ncbi Cushing's syndrome by left adrenocortical adenoma synchronously associated with primary aldosteronism by right adrenocortical adenoma: report of a case
    Naoyoshi Onoda
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Endocr J 56:495-502. 2009
    ..We reviewed the cases reported, and discussed the significance of the minute nodules in the adrenal cortex, often found in association with the adrenocortical adenoma...
  92. ncbi Primary aldosteronism and hypercortisolism due to bilateral functioning adrenocortical adenomas
    Kenji Oki
    Department of Molecular and Internal Medicine, Division of Clinical Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Hiroshima, Hiroshima, 734 8551, Japan
    Clin Exp Nephrol 12:382-7. 2008
    ....
  93. pmc Reversible posterior encephalopathy syndrome associated with micronodular adrenocortical disease and Cushing syndrome
    Maya Lodish
    Section on Endocrinology and Genetics SEGEN and Pediatric Endocrinology Program, Program on Developmental Endocrinology and Genetics PDEGEN, National Institute of Child Health and Human Development NICHD, Building 10 CRC East, Room 1 3330, 10 Center Dr MSC 1103, Bethesda, MD 20892, USA
    Eur J Pediatr 169:125-6. 2010
    We report a 6-year-old girl with ACTH-independent Cushing syndrome secondary to bilateral adrenal hyperplasia; she presented with hypertension and seizures, and magnetic resonance imaging shows changes consistent with posterior reversible ..
  94. ncbi Plasma adiponectin levels are increased despite insulin resistance in corticotropin-releasing hormone transgenic mice, an animal model of Cushing syndrome
    Masayuki Shinahara
    Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University, Kohasu, Oko cho, Nankoku, Kochi, Japan
    Endocr J 56:879-86. 2009
    ..the adipose tissue, using corticotropin-releasing hormone (CRH) transgenic mouse (CRH-Tg), an animal model of Cushing syndrome. We found, unexpectedly, that plasma AdN levels in CRHTg were significantly higher than those in wild-type ..
  95. ncbi Central serous chorioretinopathy as a presenting symptom of endogenous Cushing syndrome: a case report
    Ludovico Iannetti
    Department of Ophthalmology, Faculty of Medicine, Sapienza University, Rome, Italy
    Eur J Ophthalmol 21:661-4. 2011
    To report a case of Cushing syndrome due to adrenocortical adenoma revealed by central serous chorioretinopathy.
  96. ncbi Combined primary aldosteronism and preclinical Cushing's syndrome: an unusual case presentation of adrenal adenoma
    T Honda
    Second Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan
    Hypertens Res 24:723-6. 2001
    ..In patients with large aldosterone-producing adenoma, contralateral adrenal insufficiency should be anticipated after the removal of the tumor...
  97. ncbi A case of aldosterone-producing adrenocortical adenoma associated with preclinical Cushing's syndrome and hypersecretion of parathyroid hormone
    S Makino
    Department of Internal Medicine, Osaka Gyomeikan Hospital, Japan
    Endocr J 48:103-11. 2001
    ..Both serum calcium and PTH levels remained high one year after adrenalectomy. Ultrasonography revealed the swelling of a parathyroid gland on the left side, indicating the coexistence of an autonomous hyperparathyroidism...
  98. ncbi A case of primary aldosteronism associated with renal artery stenosis and preclinical Cushing's syndrome
    Kazuo Tsunoda
    Division of Hypertension and Diabetes Mellitus, Sendai Social Insurance Hospital, Sendai, Japan
    Hypertens Res 31:1669-75. 2008
    ..However, antihypertensive therapy could not be completely stopped. The renal dysfuntion that occurred prior to treatment seemed to prevent complete normalization of blood pressure...
  99. ncbi Cushing syndrome following the prescription of antifungal, antibiotic, corticosteroid cream
    Juan Pablo Castanedo-Cazares
    Int J Dermatol 42:318. 2003
  100. ncbi Exogenous cushing syndrome mimicking human immunodeficiency virus lipodystrophy
    Samir K Gupta
    Division of Infectious Diseases, Indiana University School of Medicine, Wishard Memorial Hospital, Indianapolis, IN, 46202, USA
    Clin Infect Dis 35:E69-71. 2002
    ..Further clinical evaluation revealed, however, that the patient had developed exogenous Cushing syndrome, which presumably was caused by the inhibition of CYP3A4's metabolism of inhaled fluticasone by the protease ..
  101. pmc Blood pressure in pediatric patients with Cushing syndrome
    Maya B Lodish
    Section on Endocrinology Genetics, Program on Developmental Endocrinology Genetics, National Institute of Child Health and Human Development, NIH, Building 10, CRC, 10 Center Drive, MSC1103, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 94:2002-8. 2009
    Hypertension (HTN) has been reported in up to 60% of children with Cushing syndrome (CS), but its course, side effects, and potential differences among various causes of CS have not been adequately studied.

Research Grants52

  1. Fatty acid Control Obesity and the Metabolic Syndrome via TPR proteins
    Terry D Hinds; Fiscal Year: 2010
    ..The molecular mechanisms behind what controls these actions are not well understood. Diseases such as Cushing Syndrome, obesity, type 2 diabetes, cardiovascular disease and the Metabolic Syndrome have been linked to the actions ..
  2. Prevalence and Correlates of Minor Depression in Type 2 Diabetes
    Sherita Hill Golden; Fiscal Year: 2012
    ..We will compare metabolic control of diabetes between those with minor depression and those with 1) major depression and 2) no depression and explore whether behavioral and hormonal factors might explain the association. ..
  3. MODEL OF HYPERCORTISOLISM FOR MAJOR DEPRESSION
    Alan F Schatzberg; Fiscal Year: 2010
    ....
  4. Mechanisms of Pituitary Tumorigenesis
    Shlomo Melmed; Fiscal Year: 2012
    ..The results will improve our understanding of clinical endocrine syndromes associated with infertility, growth disorders, hypercortisolism or adrenal, thyroid and gonadal failure due to abrogated pituitary function. ..
  5. Cortisol and Eating Behavior in Low-Income Preschool-Aged Children
    Julie C Lumeng; Fiscal Year: 2010
    ..More effective approaches to preventing and treating childhood obesity are needed. A focus on the intersection of stress, eating behavior, and obesity may inform the development of more effective intervention and prevention programs. ..
  6. REGULATION OF RNA EDITING IN THE CNS
    Ronald B Emeson; Fiscal Year: 2010
    ....
  7. DEXAMETHASONE RESISTANCE; NEUROENDOCRINE MECHANISMS
    Paul Plotsky; Fiscal Year: 1993
    ....
  8. NEUROENDOCRINE CONTROL OF K CHANNELS IN DIABETIC B-CELLS
    GEOFFREY EDDLESTON; Fiscal Year: 1992
    ....
  9. Mechanisms of Hormonal Release by Endocrine Cells
    Giulia Baldini; Fiscal Year: 2006
    ..This study of hormone release will help elucidate possible defects underlying endocrine diseases such as Diabetes Mellitus and Cushing syndrome. [unreadable] [unreadable]
  10. Physiological Roles of Receptor-Associated Immunophilins
    MARC COX; Fiscal Year: 2007
    ..Thus, these studies could also contribute drugs to a better understanding of the mechanism by which patients acquire resistance to corticosteroid drugs. [unreadable] [unreadable]..
  11. SEROTONIN 1A RECEPTOR & METABOLIC IMAGING IN DEPRESSION
    David Kupfer; Fiscal Year: 2002
    ..abstract_text> ..
  12. CEREBRAL 5HT1A RECEPTORS AND METABOLISM IN DEPRESSION
    Wayne Drevets; Fiscal Year: 2000
    ....
  13. Stress, hypercortisolism, and metabolic risk factors
    Sherita Golden; Fiscal Year: 2009
    ....
  14. PERINATAL HYPOXIA: ADRENOCORTICAL-METABOLIC ADAPTATIONS
    Hershel Raff; Fiscal Year: 2006
    ..Characterization of the hypothalamic-pituitary-adrenal and metabolic adaptations to perinatal hypoxia can lead to new diagnostic approaches and therapies to minimize morbidity and mortality. ..
  15. The mechanisms of the nicotine-induction of insulin resistance
    Theodore Friedman; Fiscal Year: 2008
    ..abstract_text> ..
  16. HPA Axis Activation and Nicotine Use
    Theodore Friedman; Fiscal Year: 2005
    ..The use of glucocorticoid synthesis inhibitors or antagonists, antalarmin, or other CRH and/or AVP antagonists, may be helpful in smoking cessation programs in humans. ..
  17. Genes and Proteins Leading to Addiction
    Theodore Friedman; Fiscal Year: 2006
    ..The focus of this proposal will be to use two new technologies, ProteinChip Array (SELDI-TOF Mass Spectrophotometry) and Gene Chip Array, to characterize and identify genes and proteins involved in opiate use. ..
  18. Chronic Nicotine's Activation of the HPA Axis
    Theodore Friedman; Fiscal Year: 2005
    ..abstract_text> ..
  19. Early Chronic Stress and Prefrontal Development
    David Lyons; Fiscal Year: 2005
    ..abstract_text> ..
  20. COGNITION, STEROIDS AND IMAGING IN CUSHINGS DISEASE
    MONICA STARKMAN; Fiscal Year: 2001
    ..The rationale for developing protective drugs such as site-specific glucocorticoid receptor antagonists or excitatory amino acid suppressors would be strengthened. ..
  21. The role of sphingolipids in the pancreatic beta cell
    Scott Summers; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  22. Guided Imagery Intervention for Obese Latino Adolescents
    Marc Weigensberg; Fiscal Year: 2007
    ..This could be an effective means of preventing both type 2 diabetes and cardiovascular disease in susceptible youth, thereby reducing both the suffering and costs associated with these diseases. [unreadable] [unreadable] [unreadable]..
  23. ROSIALITAZONE: NOVEL THERAPY FOR PITUITARY TUMORS (PHAS*
    Anthony Heaney; Fiscal Year: 2007
    ..A complete response will be defined as normalization of urinary cortisol levels in the Cushing's patients, and disappearance of pituitary tumors in the non-secreting tumors from baseline. [unreadable] [unreadable]..
  24. Role of Ceramide in Hepatic Insulin Resistance
    Scott Summers; Fiscal Year: 2008
    ..Project Description Page 6 Principal Investigator/Program Director (Last, first, middle): Summers, Scott, A. ..
  25. A Novel Tool to Understand Insulin Production and Failure in Pancreatic beta-Cell
    Israel Hodish; Fiscal Year: 2008
    ..The model presented opens new avenues to the development and testing of potential therapeutic interventions that may ultimately help preserve insulin secretory function in humans with diabetes mellitus. [unreadable] [unreadable]..
  26. Dynamical Systems Tools: Modeling multi-level processes in parent-child relations
    MELISSA L contact STURGE APPLE; Fiscal Year: 2010
    ..The tools will have the potential to lead to new discoveries of how aberrations in early stress regulation contribute to risk for physical and mental health disorders. ..
  27. HIV-Related Proteinuria and Endothelial Dysfunction
    Samir Gupta; Fiscal Year: 2007
    ..Dub6) in the fields of HIV metabolic and renal complications, renal vascular and glomerular pathology, and clinical trials design and implementation. ..
  28. The role of sphingolipids in insulin signal transduction
    Scott Summers; Fiscal Year: 2006
    ..Information garnered from these experiments could suggest novel therapeutic strategies in the treatment of insulin resistance and type 2 diabetes. [unreadable] [unreadable] [unreadable]..
  29. BENEFICIAL EFFECTS OF GINKGO BILOBA IN CANCER
    Vassilios Papadopoulos; Fiscal Year: 2002
    ..These experiments should demonstrate if EGB 761 could be used to prevent and/or stabilize the progression of cancer. ..
  30. Plasma Diagnostic for Alzheimer's Disease Pathology
    Vassilios Papadopoulos; Fiscal Year: 2004
    ..In this Phase I application we propose to test this hypothesis in a small number of samples obtained from AD and control (non-demented) patients. ..
  31. Hippocampus/Pituitary Ratio: an AD Brain Injury Marker?
    Thomas Beresford; Fiscal Year: 2005
    ..abstract_text> ..
  32. Chemoprevention of Pituitary Corticotroph Tumors
    Anthony Heaney; Fiscal Year: 2006
    ..Our ultimate goal is to develop a rationale for clinical application of these PPAR-gamma ligands as a novel medical therapy in Cushing's disease. ..
  33. Microarray analysis of thyroid neoplasm
    Martha Zeiger; Fiscal Year: 2004
    ..This will be performed using quantitative real-time RT-PCR on RNA samples from a panel of thyroid tumors. ..
  34. Maternal Availability and Postnatal Brain Development
    Karen Parker; Fiscal Year: 2005
    ..This animal model provides valuable insights on a basic process in human development, insofar as early emotional challenges foster adaptations useful later in life. ..
  35. EXTRAMURAL RESEARCH FACILITIES IMPROVEMENT
    Russell Joffe; Fiscal Year: 2004
    ..No funds are sought for basic science research laboratories or any clinical areas in the Cancer Center. ..
  36. CNS Counterregulatory Mechanisms
    Lauren Jacobson; Fiscal Year: 2004
    ..These studies will provide novel information on the neuropharmacology of glucose control that may reveal therapeutic strategies to prevent hypoglycemia unawareness. ..
  37. Role of glucocorticoids in hypoglycemia unawareness
    Lauren Jacobson; Fiscal Year: 2003
    ..abstract_text> ..
  38. Growth Hormone Secretory Dynamics in Peripubertal Girls
    Steven Pincus; Fiscal Year: 2002
    ..In particular, collaborations with pharmaceutical companies who manufacture growth hormone. ..
  39. fMRI of CBT and CM for Cocaine Dependence
    MARC POTENZA; Fiscal Year: 2009
    ..Successful completion of this project would lay the foundation for future studies (e.g., those combining behavioral and pharmacological treatments) in cocaine dependence and other addictive disorders. ..
  40. TRAINING PROGRAM IN CLINICAL RESEARCH
    David Schteingart; Fiscal Year: 2004
    ..abstract_text> ..
  41. fMRI of Craving in Addictions: Gender Differences
    MARC POTENZA; Fiscal Year: 2009
    ..abstract_text> ..
  42. Molecular Classification of Suspicious Thyroid Tumors
    Martha Zeiger; Fiscal Year: 2009
    ..abstract_text> ..
  43. Neurosteroids and acute Alcohol Intoxication in Humans
    Owen Wolkowitz; Fiscal Year: 2008
    ..abstract_text> ..
  44. REGIONAL BIOCONTAINMENT LABORATORY (RBL) NEWARK CENTER
    Russell Joffe; Fiscal Year: 2005
    ..When the RBL is operational, it will create a critical mass of biodefense scientists in Newark and serve as a specialized laboratory for emerging regional and national biodefense needs. ..
  45. Michigan Mentored Clinical Scholars Program
    David Schteingart; Fiscal Year: 2007
    ..On the basis of these resources, we are confident we can offer an outstanding pro_am for the training of clinical research scholars. ..
  46. Selegiline for Smoking Cessation
    MARC POTENZA; Fiscal Year: 2007
    ..Positive results from this trial would add further support for the safety and efficacy of selegiline for the treatment of nicotine dependence. ..