tendon injuries

Summary

Summary: Injuries to the fibrous cords of connective tissue which attach muscles to bones or other structures.

Top Publications

  1. pmc Characterization of differential properties of rabbit tendon stem cells and tenocytes
    Jianying Zhang
    MechanoBiology Laboratory, Departments of Orthopaedic Surgery, Bioengineering, and Mechanical Engineering and Materials Science, University of Pittsburgh, Pittsburgh, PA 15213, USA
    BMC Musculoskelet Disord 11:10. 2010
  2. pmc The role of engineered tendon matrix in the stemness of tendon stem cells in vitro and the promotion of tendon-like tissue formation in vivo
    Jianying Zhang
    Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Biomaterials 32:6972-81. 2011
  3. pmc Conversion of mechanical force into TGF-β-mediated biochemical signals
    Toru Maeda
    Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Curr Biol 21:933-41. 2011
  4. ncbi The results of repair of massive tears of the rotator cuff
    C Gerber
    Department of Orthopaedics, University of Zurich, Switzerland
    J Bone Joint Surg Am 82:505-15. 2000
  5. ncbi Platelet-rich plasma releasate promotes differentiation of tendon stem cells into active tenocytes
    Jianying Zhang
    Department of Orthopaedic Surgery, University of Pittsburgh, PA 15213, USA
    Am J Sports Med 38:2477-86. 2010
  6. ncbi Tendon-derived stem cells (TDSCs) promote tendon repair in a rat patellar tendon window defect model
    Ming Ni
    Department of Orthopaedics and Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
    J Orthop Res 30:613-9. 2012
  7. ncbi Mechanobiology of tendon
    James H C Wang
    MechanoBiology Laboratory, Department of Orthopaedic Surgery, University of Pittsburgh, 210 Lothrop St, BST, E1647, Pittsburgh, PA 15213, USA
    J Biomech 39:1563-82. 2006
  8. pmc Macrophage sub-populations and the lipoxin A4 receptor implicate active inflammation during equine tendon repair
    Stephanie Georgina Dakin
    Department of Veterinary Clinical Sciences, Royal Veterinary College, University of London, Hatfield, United Kingdom
    PLoS ONE 7:e32333. 2012
  9. ncbi Inflammation in overuse tendon injuries
    Lucy Battery
    Centre for Sports and Exercise Medicine, Queen Mary University of London, Barts and the London School of Medicine and Dentistry, Mile End Hospital, London, England
    Sports Med Arthrosc 19:213-7. 2011
  10. ncbi Repair of patellar tendon injuries using a cell-collagen composite
    Hani A Awad
    Noyes Giannestras Biomechanics Laboratories, Department of Biomedical Engineering, University of Cincinnati, 2901 Campus Drive, P O Box 210048, OH 45221 0048, USA
    J Orthop Res 21:420-31. 2003

Detail Information

Publications349 found, 100 shown here

  1. pmc Characterization of differential properties of rabbit tendon stem cells and tenocytes
    Jianying Zhang
    MechanoBiology Laboratory, Departments of Orthopaedic Surgery, Bioengineering, and Mechanical Engineering and Materials Science, University of Pittsburgh, Pittsburgh, PA 15213, USA
    BMC Musculoskelet Disord 11:10. 2010
    ..However, the differential properties of TSCs and tenocytes remain largely undefined. This study aims to characterize the properties of these tendon cells derived from rabbits...
  2. pmc The role of engineered tendon matrix in the stemness of tendon stem cells in vitro and the promotion of tendon-like tissue formation in vivo
    Jianying Zhang
    Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Biomaterials 32:6972-81. 2011
    ..Together, the findings of this study indicate that ETM may be used to effectively expand TSCs in vitro and with TSCs, to enhance repair of injured tendons in vivo...
  3. pmc Conversion of mechanical force into TGF-β-mediated biochemical signals
    Toru Maeda
    Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Curr Biol 21:933-41. 2011
    ..Our findings demonstrate a critical role for mechanical force in adult tendon homeostasis. Furthermore, this mechanism could translate physical force into biochemical signals in a much broader variety of tissues or systems in the body...
  4. ncbi The results of repair of massive tears of the rotator cuff
    C Gerber
    Department of Orthopaedics, University of Zurich, Switzerland
    J Bone Joint Surg Am 82:505-15. 2000
    ....
  5. ncbi Platelet-rich plasma releasate promotes differentiation of tendon stem cells into active tenocytes
    Jianying Zhang
    Department of Orthopaedic Surgery, University of Pittsburgh, PA 15213, USA
    Am J Sports Med 38:2477-86. 2010
    ..The aim of this study was to determine the effects of PRP, in the form of PRP-clot releasate (PRCR), on tendon stem cells (TSCs), a newly discovered cell population in tendons...
  6. ncbi Tendon-derived stem cells (TDSCs) promote tendon repair in a rat patellar tendon window defect model
    Ming Ni
    Department of Orthopaedics and Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
    J Orthop Res 30:613-9. 2012
    ..In conclusion, TDSCs promoted earlier and better repair in a rat patellar tendon window defect model...
  7. ncbi Mechanobiology of tendon
    James H C Wang
    MechanoBiology Laboratory, Department of Orthopaedic Surgery, University of Pittsburgh, 210 Lothrop St, BST, E1647, Pittsburgh, PA 15213, USA
    J Biomech 39:1563-82. 2006
    ..Finally, future research directions in tendon mechanobiology research are discussed...
  8. pmc Macrophage sub-populations and the lipoxin A4 receptor implicate active inflammation during equine tendon repair
    Stephanie Georgina Dakin
    Department of Veterinary Clinical Sciences, Royal Veterinary College, University of London, Hatfield, United Kingdom
    PLoS ONE 7:e32333. 2012
    ....
  9. ncbi Inflammation in overuse tendon injuries
    Lucy Battery
    Centre for Sports and Exercise Medicine, Queen Mary University of London, Barts and the London School of Medicine and Dentistry, Mile End Hospital, London, England
    Sports Med Arthrosc 19:213-7. 2011
    Overuse tendon injuries present with pain and swelling of the affected tendon with associated decrease in exercise tolerance and function of the limb...
  10. ncbi Repair of patellar tendon injuries using a cell-collagen composite
    Hani A Awad
    Noyes Giannestras Biomechanics Laboratories, Department of Biomedical Engineering, University of Cincinnati, 2901 Campus Drive, P O Box 210048, OH 45221 0048, USA
    J Orthop Res 21:420-31. 2003
    ....
  11. ncbi Ultrasonographic assessment of the superficial digital flexor tendons of National Hunt racehorses in training over two racing seasons
    C S Avella
    Department of Veterinary Clinical Sciences, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire AL9 7TA, UK
    Equine Vet J 41:449-54. 2009
    ..It is important to ascertain the prevalence of superficial digital flexor tendon (SDFT) injuries and to improve methods of predicting injury in National Hunt (NH) racehorses...
  12. ncbi Functional tissue engineering for tendon repair: A multidisciplinary strategy using mesenchymal stem cells, bioscaffolds, and mechanical stimulation
    David L Butler
    Department of Biomedical Engineering, 840 Engineering Research Center, Colleges of Engineering and Medicine, University of Cincinnati, 2901 Woodside Drive, Cincinnati, Ohio 45221 0048, USA
    J Orthop Res 26:1-9. 2008
    ..Our contributions in the area of tendon functional tissue engineering have the potential to create functional load-bearing repairs that will revolutionize surgical reconstruction after tendon and ligament injury...
  13. ncbi Allogenous tendon stem/progenitor cells in silk scaffold for functional shoulder repair
    Weiliang Shen
    Center for Stem Cell and Tissue Engineering, School of Medicine, Zhejiang University, Hangzhou, China
    Cell Transplant 21:943-58. 2012
    ..Hence, allogenous TSPC-seeded knitted silk-collagen sponge scaffolds can be a clinically useful application for tendon tissue engineering...
  14. ncbi Prevalence of superficial digital flexor tendonitis and suspensory desmitis in Japanese Thoroughbred flat racehorses in 1999
    Y Kasashima
    Equine Research Institute, Japan Racing Association, 321 4, Tokami cho, Utsunomiya Shi, Tochigi, 320 0856, Japan
    Equine Vet J 36:346-50. 2004
    ..However, since tendon injury during training is seen commonly in clinical practice, it is appropriate to determine the overall prevalence of tendon injury sustained during both training and racing...
  15. pmc The effects of dexamethasone on human patellar tendon stem cells: implications for dexamethasone treatment of tendon injury
    Jianying Zhang
    MechanoBiology Laboratory, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, 210 Lothrop Street, BST, E1640, Pittsburgh, Pennsylvania 15213, USA
    J Orthop Res 31:105-10. 2013
    ..g., fatty and cartilage-like tissues), which make tendon susceptible to rupture...
  16. pmc Aspartic acid racemization and collagen degradation markers reveal an accumulation of damage in tendon collagen that is enhanced with aging
    Chavaunne T Thorpe
    Division of Surgery and Interventional Science, University College London, Institute of Orthopaedics and Musculoskeletal Science, Royal National Orthopaedic Hospital, London, UK
    J Biol Chem 285:15674-81. 2010
    ..We propose that increased susceptibility to injury in older individuals results from an inability to remove partially degraded collagen from the matrix leading to reduced mechanical competence...
  17. ncbi Tenogenic differentiation of stem cells for tendon repair-what is the current evidence?
    P P Y Lui
    Department of Orthopaedics and Traumatology, Chinese University of Hong Kong, Hong Kong SAR, China
    J Tissue Eng Regen Med 5:e144-63. 2011
    ..Finally, further directions for promoting and assessing tenogenic differentiation of stem cells for tendon repair are discussed...
  18. ncbi Use of mesenchymal stem cells in a collagen matrix for Achilles tendon repair
    R G Young
    Osiris Therapeutics, Cleveland, Ohio, USA
    J Orthop Res 16:406-13. 1998
    ..The results indicate that delivering mesenchymal stem cell-contracted, organized collagen implants to large tendon defects can significantly improve the biomechanics, structure, and probably the function of the tendon after injury...
  19. ncbi Evaluation of a cross-linked acellular porcine dermal patch for rotator cuff repair augmentation in an ovine model
    Gregory P Nicholson
    Rush University Medical Center, Chicago, IL, USA
    J Shoulder Elbow Surg 16:S184-90. 2007
    ..Macrophages had disappeared from the PD groups, and integration of the PD patch into the surrounding tissue with vascular and fibroblastic invasion was seen. For the SIS group, diverse tissue types (including ectopic bone) were seen...
  20. ncbi Augmentation of a rotator cuff suture repair using rhPDGF-BB and a type I bovine collagen matrix in an ovine model
    Christopher K Hee
    Sports Medicine, BioMimetic Therapeutics, Franklin, Tennessee 37067, USA
    Am J Sports Med 39:1630-9. 2011
    ..One such growth factor is platelet-derived growth factor-BB (PDGF-BB), which has been shown to improve healing in tendon and bone repair models...
  21. ncbi Flexor tendon tissue engineering: acellularization of human flexor tendons with preservation of biomechanical properties and biocompatibility
    Brian C Pridgen
    Section of Plastic Surgery, VA Palo Alto Health Care System and the Division of Plastic Surgery, Stanford University Medical Center, Stanford, California 94305, USA
    Tissue Eng Part C Methods 17:819-28. 2011
    ..Acellular human tendons are a candidate scaffold for tissue engineering flexor tendons of the hand. This study compared acellularization methods and their compatibility with allogeneic human cells...
  22. ncbi Tendon disorders of the foot and ankle, part 2: achilles tendon disorders
    Daniel S Heckman
    Department of Orthopaedic Surgery, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
    Am J Sports Med 37:1223-34. 2009
    ....
  23. ncbi The role of platelet-rich plasma in arthroscopic rotator cuff repair: a systematic review with quantitative synthesis
    Jaskarndip Chahal
    Division of Sports Medicine, Rush University Medical Center, Chicago, Illinois, USA
    Arthroscopy 28:1718-27. 2012
    ....
  24. ncbi Flexor tendon injuries following locked volar plating of distal radius fractures
    Andrew W Cross
    Allegheny Hand Center, Allegheny General Hospital, Pittsburgh, PA 15212, USA
    J Hand Surg Am 33:164-7. 2008
    ..We suggest close follow-up of all fractures in which the distal end of the plate is anterior to the radial rim and removal of hardware if symptoms suggest tendon irritation...
  25. ncbi The relationship between in vivo limb and in vitro tendon mechanics after injury: a potential novel clinical tool for monitoring tendon repair
    S G Dakin
    Department of Veterinary Clinical Sciences, The Royal Veterinary College, Hertfordshire, UK
    Equine Vet J 43:418-23. 2011
    ..This study investigated the consequences of SDF tendinopathy on limb mechanics in relation to the mechanical properties of injured tendon...
  26. ncbi Effects of sodium-hyaluronate and glucosamine-chondroitin sulfate on remodeling stage of tenotomized superficial digital flexor tendon in rabbits: a clinical, histopathological, ultrastructural, and biomechanical study
    Ahmad Oryan
    Department of Pathology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
    Connect Tissue Res 52:329-39. 2011
    ....
  27. pmc Increased expression of IL-6 family members in tendon pathology
    Kirsten Legerlotz
    School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK
    Rheumatology (Oxford) 51:1161-5. 2012
    ..The aim of this study was to investigate the expression of IL-6 family members in painful posterior tibialis tendon (PTT) and in painful and ruptured Achilles tendon (AT) compared with normal tendon...
  28. ncbi Nonsteroidal anti-inflammatory drug reduces neutrophil and macrophage accumulation but does not improve tendon regeneration
    David Marsolais
    Department of Rehabilitation, Faculty of Medicine, Universite Laval, Quebec, Canada
    Lab Invest 83:991-9. 2003
    ..These results indicate that diclofenac reduced both edema and the accumulation of inflammatory cells within the paratenon but provided no biochemical or functional benefits for the Achilles tendon...
  29. pmc The relationships among spatiotemporal collagen gene expression, histology, and biomechanics following full-length injury in the murine patellar tendon
    Nathaniel A Dyment
    University of Cincinnati, Cincinnati, OH, USA
    J Orthop Res 30:28-36. 2012
    b>Tendon injuries are major orthopedic problems that worsen as the population ages. Type-I (Col1) and type-II (Col2) collagens play important roles in tendon midsubstance and tendon-to-bone insertion healing, respectively...
  30. ncbi Structural and functional modulation of early healing of full-thickness superficial digital flexor tendon rupture in rabbits by repeated subcutaneous administration of exogenous human recombinant basic fibroblast growth factor
    Ali Moshiri
    Veterinary Surgery and Radiology, Department of Surgery and Radiology, Shiraz University School of Veterinary Medicine, Shiraz, Iran
    J Foot Ankle Surg 50:654-62. 2011
    ..Treatment with basic fibroblast growth factor was effective in restoring the morphologic and biomechanical properties of the injured superficial digital flexor tendon and could be valuable in clinical trial studies...
  31. ncbi Biomechanical evaluation of arthroscopic rotator cuff stitches
    C Benjamin Ma
    The Hospital for Special Surgery, New York, NY 10021, USA
    J Bone Joint Surg Am 86:1211-6. 2004
    ..The goal of this study was to determine the biomechanical properties of the massive cuff stitch and to compare it with other stitches commonly used for rotator cuff repair...
  32. ncbi Clinical outcome and imaging of arthroscopic single-row and double-row rotator cuff repair: a prospective randomized trial
    Hsiao Li Ma
    National Yang Ming University School of Medicine, Taipei, Taiwan
    Arthroscopy 28:16-24. 2012
    ....
  33. ncbi Arthroscopic rotator cuff repair using a suture bridge technique: is the repair integrity actually maintained?
    Nam Su Cho
    Shoulder and Elbow Clinic, Department of Orthopaedic Surgery, College of Medicine, Kyung Hee University, Seoul, Korea
    Am J Sports Med 39:2108-16. 2011
    ..Suture bridge repair has been recognized to have superior biomechanical characteristics, as shown in previous biomechanical studies. However, it is not clear whether the tendon heals better in vivo after suture bridge repair...
  34. ncbi Tendinopathy and inflammation: some truths
    A Del Buono
    Department of Orthopaedic and Trauma Surgery, Campus Biomedico University of Rome, Via Alvaro del Portillo, Rome, Italy
    Int J Immunopathol Pharmacol 24:45-50. 2011
    ..Further studies may reveal novel therapeutic treatment approaches...
  35. pmc Full-thickness supraspinatus tears are associated with more synovial inflammation and tissue degeneration than partial-thickness tears
    Michael K Shindle
    Sports Medicine and Shoulder Service, Hospital for Special Surgery, New York, NY, USA
    J Shoulder Elbow Surg 20:917-27. 2011
    ..We hypothesized that increased synovial inflammation would correlate with greater tear size of the supraspinatus tendon at the time of surgery...
  36. pmc Symptomatic progression of asymptomatic rotator cuff tears: a prospective study of clinical and sonographic variables
    Nathan A Mall
    Department of Orthopaedic Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Bone Joint Surg Am 92:2623-33. 2010
    ....
  37. ncbi Remodeling of murine intrasynovial tendon adhesions following injury: MMP and neotendon gene expression
    Alayna E Loiselle
    Department of Orthopaedics, The Center for Musculoskeletal Research, University of Rochester Box 665, 601 Elmwood Avenue, Rochester, New York 14620, USA
    J Orthop Res 27:833-40. 2009
    ..The murine model of primary tendon repair, described here, provides a novel mechanism to study the tendon healing process, and further enhances the understanding of this process at the molecular, cellular, and biomechanical level...
  38. ncbi Biomechanics of tendon injury and repair
    T W Tony W Lin
    McKay Orthopaedic Research Laboratory, University of Pennsylvania, 424 Stemmler Hall, 36th and Hamilton Walk, Philadelphia, PA 19104 6081, USA
    J Biomech 37:865-77. 2004
    ..Finally, current and future treatment modalities for improving tendon healing, such as tissue engineering, cell therapy, and gene therapy, are reviewed...
  39. ncbi A review of tendon injury: why is the equine superficial digital flexor tendon most at risk?
    C T Thorpe
    University College London, Division of Surgery and Interventional Science, Institute of Orthopaedics and Musculoskeletal Science, Stanmore Campus, Royal National Orthopaedic Hospital, Stanmore, London HA7 4LP
    Equine Vet J 42:174-80. 2010
    Tendon injury is one of the most common causes of wastage in the performance horse; the majority of tendon injuries occur to the superficial digital flexor tendon (SDFT) whereas few occur to the common digital extensor tendon...
  40. ncbi Functional efficacy of tendon repair processes
    David L Butler
    Department of Biomedical Engineering, Noyes Giannestras Biomechanics Laboratory, University of Cincinnati, Cincinnati, Ohio 45221 0048, USA
    Annu Rev Biomed Eng 6:303-29. 2004
    ..The paper concludes with future directions...
  41. ncbi Abnormal tenocyte morphology is more prevalent than collagen disruption in asymptomatic athletes' patellar tendons
    J L Cook
    Musculoskeletal Research Centre, La Trobe University, Victoria 3086, Australia
    J Orthop Res 22:334-8. 2004
    ..No tendons demonstrated neovascularization. It appears that cellular changes must be present if there is an increase in ground substance, or collagen and vascular changes. Further research is required to confirm these findings...
  42. ncbi Cumulative incidence of achilles tendon rupture and tendinopathy in male former elite athletes
    Urho M Kujala
    Department of Health Sciences, University of Jyvaskyla, Jyvaskyla, Finland
    Clin J Sport Med 15:133-5. 2005
    ..To study the cumulative incidence of Achilles tendon rupture and tendinopathy among former top-level athletes...
  43. ncbi Extracellular matrix biomaterials for soft tissue repair
    Kevin G Cornwell
    TEI Biosciences Inc, 7 Elkins Street, Boston, MA 02127, USA
    Clin Podiatr Med Surg 26:507-23. 2009
    ....
  44. ncbi Temporal expression of growth factors and matrix molecules in healing tendon lesions
    Linda A Dahlgren
    Comparative Orthopaedics Laboratory, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, C3 187 Veterinary Medical Ctr, Ithaca, NY 14853, USA
    J Orthop Res 23:84-92. 2005
    Overuse tendon injuries are common among elite and recreational athletes...
  45. ncbi Biology of tendon injury: healing, modeling and remodeling
    P Sharma
    Salisbury District Hospital, Wessex Deanery, United Kingdom
    J Musculoskelet Neuronal Interact 6:181-90. 2006
    ..b>Tendon injuries account for considerable morbidity, and often prove disabling for several months, despite what is considered ..
  46. ncbi Regenerative versus reparative healing in tendon: a study of biomechanical and histological properties in fetal sheep
    Pedro K Beredjiklian
    McKay Orthopaedic Research Laboratory, University of Pennsylvania, Philadelphia, PA, USA
    Ann Biomed Eng 31:1143-52. 2003
    ..A better understanding of the mechanisms of fetal healing may lead to novel therapeutic strategies in the clinical setting...
  47. ncbi Clinical implications of growth factors in flexor tendon wound healing
    Charles Hsu
    Division of Plastic Surgery, Department of Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA
    J Hand Surg Am 29:551-63. 2004
    ....
  48. pmc The cellular biology of flexor tendon adhesion formation: an old problem in a new paradigm
    Jason K F Wong
    University of Manchester, United Kingdom
    Am J Pathol 175:1938-51. 2009
    Intrasynovial flexor tendon injuries of the hand can frequently be complicated by tendon adhesions to the surrounding sheath, limiting finger function...
  49. ncbi Cuff integrity after arthroscopic versus open rotator cuff repair: a prospective study
    Julie Bishop
    Columbus Bone, Joint and Hand Surgeons, Inc, Columbus, OH, USA
    J Shoulder Elbow Surg 15:290-9. 2006
    ..01) and external rotation (P = .02). We conclude that open and arthroscopic RCRs have similar clinical outcomes. Cuff integrity is comparable for small tears, but large tears have twice the retear rate after arthroscopic repair...
  50. ncbi From mechanical loading to collagen synthesis, structural changes and function in human tendon
    M Kjaer
    Department of Orthopaedics, Institute of Sports Medicine, Bispebjerg Hospital, Copenhagen, Denmark
    Scand J Med Sci Sports 19:500-10. 2009
    ..An intimate interplay between mechanical signalling and biochemical changes in the matrix is needed in tendon, such that chemical changes can be converted into adaptations in the morphology, structure and material properties...
  51. ncbi Surgically repaired massive rotator cuff tears: MRI of tendon integrity, muscle fatty degeneration, and muscle atrophy correlated with intraoperative and clinical findings
    J M Mellado
    Institut de Diagnostic per la Imatge, Hospital Universitari de Tarragona Joan XXIII, Carrer Doctor Mallafrè Guasch, 4, 43007 Tarragona, Spain
    AJR Am J Roentgenol 184:1456-63. 2005
    ....
  52. ncbi Reversal of suprascapular neuropathy following arthroscopic repair of massive supraspinatus and infraspinatus rotator cuff tears
    John G Costouros
    Harvard Shoulder Service, Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Arthroscopy 23:1152-61. 2007
    ....
  53. ncbi Bridging tendon defects using autologous tenocyte engineered tendon in a hen model
    Yilin Cao
    Department of Plastic and Reconstructive Surgery, Shanghai Ninth People s Hospital, Tissue Engineering Center, Shanghai Second Medical University, Shanghai, ROC
    Plast Reconstr Surg 110:1280-9. 2002
    ..The engineered tendons resembled natural tendons not only in gross appearance and histologic structure but also in biomechanical properties...
  54. ncbi Repair of tendon defect with dermal fibroblast engineered tendon in a porcine model
    Wei Liu
    Department of Plastic and Reconstructive Surgery, Shanghai Ninth People s Hospital, Shanghai Tissue Engineering Center, Shanghai Second Medical University, Shanghai, PR China
    Tissue Eng 12:775-88. 2006
    ..05). These results suggest that dermal fibroblasts may have the potential as seed cells for tendon engineering...
  55. ncbi Platelet-rich plasma treatment for ligament and tendon injuries
    Justin Paoloni
    Sports Medicine Department, ASPETAR, Qatar Orthopaedic and Sports Medicine Hospital, Doha, Qatar
    Clin J Sport Med 21:37-45. 2011
    ..evidence regarding randomized clinical trials assessing the efficacy of PRP in treating ligament and tendon injuries. Basic science and animal studies and small case series reports on PRP injections for ligament or tendon ..
  56. ncbi Delayed rupture of the flexor pollicis longus tendon after routine volar placement of a T-plate on the distal radius
    Scott F M Duncan
    Mayo Clinic Hospital, Scottsdale, AZ 85054, USA
    Am J Orthop (Belle Mead NJ) 36:669-70. 2007
  57. ncbi Hyperthermia induced by microwave diathermy in the management of muscle and tendon injuries
    A Giombini
    Institute of Sport Medicine and Science, Rome, Italy
    Br Med Bull 83:379-96. 2007
    ....
  58. ncbi Increased cartilage oligomeric matrix protein concentrations in equine digital flexor tendon sheath synovial fluid predicts intrathecal tendon damage
    Matthew R W Smith
    Royal Veterinary College, Equine Referral Hospital, North Mymms, UK
    Vet Surg 40:54-8. 2011
    ..To evaluate digital flexor tendon sheath (DFTS) synovial fluid cartilage oligomeric matrix protein (COMP) concentrations as a molecular marker for intrathecal pathology...
  59. ncbi The effect of a local application of fibroblast growth factor-2 on tendon-to-bone remodeling in rats with acute injury and repair of the supraspinatus tendon
    Junji Ide
    Department of Orthopaedic and Neuro Musculoskeletal Surgery, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    J Shoulder Elbow Surg 18:391-8. 2009
    ..Twelve animals each at 2, 4, and 6 weeks after surgery were sacrificed for histological analysis (n = 5) and biomechanical Q1 testing (n = 7)...
  60. ncbi Arthroscopic supraspinatus tendon repair with suture-bridging technique: functional outcome and magnetic resonance imaging
    Christine Voigt
    Department of Trauma and Reconstructive Surgery, Friederikenstift Hospital Hannover, Hannover, Germany
    Am J Sports Med 38:983-91. 2010
    ..The suture-bridging technique is a new arthroscopic technique to repair rotator cuff tears. Biomechanical advantages compared with double-row fixations have been described...
  61. ncbi Rupture of flexor tendon following volar plate of distal radius fracture. Report of five cases
    S E Valbuena
    Department of Orthopaedic Surgery and Traumatology, Hospital Interzonal El Cruce, Alta complejidad en red, Buenos Aires, Argentina
    Chir Main 29:109-13. 2010
    ..We review the literature and discuss the aetiology of tendon ruptures and techniques to prevent tendon attition...
  62. ncbi Retear patterns after arthroscopic rotator cuff repair: single-row versus suture bridge technique
    Nam Su Cho
    Department of Orthopaedic Surgery, Kyung Hee University School of Medicine, Dongdaemun Gu, Seoul 130 702, Korea
    Am J Sports Med 38:664-71. 2010
    ..A subset of patients is often seen with an unusual pattern of tendon failure after arthroscopic rotator cuff repair using a suture bridge technique...
  63. ncbi Tendon disorders of the foot and ankle, part 1: peroneal tendon disorders
    Daniel S Heckman
    Department of Orthopaedic Surgery, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
    Am J Sports Med 37:614-25. 2009
    ....
  64. ncbi Phenotypic drift in human tenocyte culture
    L Yao
    Department of Orthopaedic Surgery, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK
    Tissue Eng 12:1843-9. 2006
    ..9 +/- 3.1 ng/ng of DNA at passage 1, to 9.1 +/- 1.8 ng/ng of DNA at passage 8 ( p < 0.001). Integrin expression did not change. We conclude that the phenotype of tenocytes in culture rapidly drifts with progressive passage...
  65. ncbi Repeated administration of exogenous Sodium-hyaluronate improved tendon healing in an in vivo transection model
    Ahmad Oryan
    Department of Pathology, Veterinary School, Shiraz University, Shiraz, Iran
    J Tissue Viability 21:88-102. 2012
    ..This study was designed to evaluate the effects of exogenous Sodium-Hyaluronate (NaH) on full thickness Superficial Digital Flexor Tendon (SDFT) rupture in the early phase of healing in rabbits...
  66. ncbi Ectopic chondro-ossification and erroneous extracellular matrix deposition in a tendon window injury model
    Pauline Po Yee Lui
    Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, China
    J Orthop Res 30:37-46. 2012
    ..Higher expression of biglycan and aggrecan were observed in the ectopic chondro-ossification sites in the repair tissue, suggesting that they might have roles in ectopic chondro-osteogenesis...
  67. ncbi Platelet-rich plasma and the upper extremity
    Allan Mishra
    Department of Orthopaedic Surgery, Menlo Medical Clinic, Stanford University Medical Center, 1300 Crane Street, Menlo Park, CA 94025, USA
    Hand Clin 28:481-91. 2012
    ..This article explores the scientific rational for using PRP, its various formulations, and the emerging clinical data. Future potential applications are also explored...
  68. ncbi The effect of platelet-rich fibrin matrix on rotator cuff tendon healing: a prospective, randomized clinical study
    Scott A Rodeo
    The Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA
    Am J Sports Med 40:1234-41. 2012
    ..Platelet-rich fibrin matrix (PRFM) allows delivery of autologous cytokines to healing tissue, and limited evidence suggests a positive effect of platelet-rich plasma on tendon biology...
  69. ncbi Effects of platelet-rich fibrin matrix on repair integrity of at-risk rotator cuff tears
    Adam G Bergeson
    Department of Orthopaedics, University of Utah, Salt Lake City, 84108, USA
    Am J Sports Med 40:286-93. 2012
    ..Platelets are an endogenous source of growth factors present during rotator cuff healing...
  70. pmc Regulation of gene expression in human tendinopathy
    Scott A Jelinsky
    Tissue Repair, Pfizer Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA
    BMC Musculoskelet Disord 12:86. 2011
    Chronic tendon injuries, also known as tendinopathies, are common among professional and recreational athletes...
  71. pmc Prospective randomised comparison of arthroscopic versus mini-open rotator cuff repair of the supraspinatus tendon
    Philip Kasten
    Division of Shoulder and Elbow Surgery and Sports Medicine, Department of Orthopaedic Surgery, Carl Gustav Carus University of Dresden, Fetscherstr 74, 01307, Dresden, Germany
    Int Orthop 35:1663-70. 2011
    ..The aim of the study was to evaluate whether arthroscopic (ASC) repair of rotator cuff ruptures causes less postoperative pain and better range of motion (ROM) in the early postoperative period than a mini-open (MO) technique...
  72. pmc Hypoxia-mediated efficient expansion of human tendon-derived stem cells in vitro
    Wayne Yuk Wai Lee
    Department of Orthopaedics and Traumatology, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong SAR, China
    Tissue Eng Part A 18:484-98. 2012
    ..In conclusion, hypoxia is advantageous for efficient expansion of hTDSCs in vitro for tendon tissue engineering...
  73. ncbi What determines the costs of repair and rehabilitation of flexor tendon injuries in zone II? A multiple regression analysis of data from southern Sweden
    H E Rosberg
    Department of Hand Surgery, Lund University, Malmo University Hospital, Sweden
    J Hand Surg Br 28:106-12. 2003
    The epidemiology and costs of repair and rehabilitation of zone II flexor tendon injuries in 135 patients from the southern part of Sweden were analysed...
  74. ncbi A meta-analysis of randomised controlled trials comparing conventional to minimally invasive approaches for repair of an Achilles tendon rupture
    Samuel E McMahon
    Watford General Hospital, 60 Vicarage Rd, Watford WD18 OHB, United Kingdom
    Foot Ankle Surg 17:211-7. 2011
    ..05). However, MIS had a significantly reduced risk of superficial wound infection, with three times greater patient satisfaction for good to excellent results compared with conventional open surgical approaches...
  75. ncbi A pathomechanical concept explains muscle loss and fatty muscular changes following surgical tendon release
    Dominik C Meyer
    Department of Orthopaedic Surgery, University of Zurich, Balgrist, Forchstr 340, 8008 Zurich, Switzerland
    J Orthop Res 22:1004-7. 2004
    ..Fatty infiltration is therefore not seen as a degenerative process but a necessary rearrangement of the tissue after macroarchitectural changes caused by musculo-tendinous retraction...
  76. ncbi Expression of matrix metalloproteinases 1, 3, and 9 in differing extents of tendon retraction in the torn rotator cuff
    Stefan Lakemeier
    Department of Orthopedics and Rheumatology, University Hospital Marburg, Baldingerstrasse, 35043, Marburg, Germany
    Knee Surg Sports Traumatol Arthrosc 19:1760-5. 2011
    ....
  77. ncbi Asymmetric atrophy of the supraspinatus muscle following tendon tear
    Dominik C Meyer
    Department of Orthopaedics, University of Zurich, Balgrist, Forchstrasse 340, 8008 Zurich, Switzerland
    J Orthop Res 23:254-8. 2005
    ..Muscular changes are not simply a consequence of muscle disuse, but dependent on architectural changes in the muscle...
  78. ncbi MR imaging of ligament and tendon injuries of the fingers
    Juan A Clavero
    Department of Radiology, Diagnosis Médica, Calle Corcega 345, 08037 Barcelona, Spain
    Radiographics 22:237-56. 2002
    ..Radiologists need to understand the full spectrum of finger abnormalities and associated MR imaging findings...
  79. pmc Natural history of fatty infiltration and atrophy of the supraspinatus muscle in rotator cuff tears
    Barbara Melis
    Centre Orthopedique Santy, Lyon, France
    Clin Orthop Relat Res 468:1498-505. 2010
    ..Fatty infiltration progresses throughout the nonoperative treatment although it is not known at what point fatty infiltration contributes to poor functional outcomes, absence of healing, or increased rerupture rates...
  80. ncbi Increased expression of aggrecan and biglycan mRNA in Achilles tendinopathy
    A N Corps
    Rheumatology Research Unit, Department of Trauman and Orthopedics, Addenbrooke s Hospital, Cambridge, UK
    Rheumatology (Oxford) 45:291-4. 2006
    ..To determine the expression of mRNA encoding the proteoglycans aggrecan, versican, biglycan and decorin in mid-tendon samples of chronic painful Achilles tendinopathy and ruptured Achilles tendons, compared with normal tendons...
  81. ncbi Management of chronic ruptures of the Achilles tendon
    Nicola Maffulli
    Department of Trauma and Orthopaedic Surgery, Keele University School of Medicine, Thornburrow Drive, Hartshill, Stoke on Trent ST4 7QB Staffs, England
    J Bone Joint Surg Am 90:1348-60. 2008
    ..They have become more common as acute Achilles tendon injuries have become more frequent, and they are associated with considerable functional morbidity...
  82. ncbi Role of metalloproteinases in rotator cuff tear
    Raffaele Garofalo
    Department of Orthopedic and Traumatology, F Miulli Hospital, Acquaviva delle Fonti, Bari, Italy
    Sports Med Arthrosc 19:207-12. 2011
    ..A better understanding of relationship and activity of these molecules could provide better strategies to optimize outcomes of rotator cuff therapy...
  83. ncbi Radiography and US of os peroneum fractures and associated peroneal tendon injuries: initial experience
    Monica K Brigido
    Department of Radiology, University of Michigan Medical Center, 1500 E Medical Center Dr, TC 2808, Ann Arbor, MI 48109 0326, USA
    Radiology 237:235-41. 2005
    To retrospectively evaluate the imaging features of os peroneum fractures and associated peroneus longus tendon injuries at radiography and ultrasonography (US) and to retrospectively compare these imaging features with those of ..
  84. ncbi Metalloproteases and rotator cuff disease
    Angelo Del Buono
    Department of Orthopaedic and Trauma Surgery, Campus Biomedico, University of Rome, Rome, Italy
    J Shoulder Elbow Surg 21:200-8. 2012
    ..Further studies are needed to better define the mechanism of action, and whether these new strategies are safe and effective in larger models...
  85. ncbi Factors affecting rotator cuff healing after arthroscopic repair: osteoporosis as one of the independent risk factors
    Seok Won Chung
    Department of Orthopaedic Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Korea
    Am J Sports Med 39:2099-107. 2011
    ..The prognostic factors associated with structural outcome after arthroscopic rotator cuff repair have not yet been fully determined...
  86. ncbi Cumulative incidence of shoulder region tendon injuries in male former elite athletes
    J A Kettunen
    ORTON Orthopaedic Hospital ORTON Foundation ARCADA University of Applied Sciences, Helsinki, Finland
    Int J Sports Med 32:451-4. 2011
    Some types of sports are thought to include a high risk for shoulder region tendon injuries but little data exist on long-term cumulative incidence of these injuries...
  87. ncbi Biologic aspects of flexor tendon laceration and repair
    Pedro K Beredjiklian
    Presbyterian Medical Center, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    J Bone Joint Surg Am 85:539-50. 2003
  88. pmc Impact of Smad3 loss of function on scarring and adhesion formation during tendon healing
    Evan B Katzel
    Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester, Rochester, New York, USA
    J Orthop Res 29:684-93. 2011
    ..Thus, Smad3(-/-) mice have reduced collagen and increased MMP9 gene and protein expression and decreased scarring following tendon FDL tendon repair...
  89. ncbi Major functional deficits persist 2 years after acute Achilles tendon rupture
    Nicklas Olsson
    Department of Orthopaedics, Institute of Clinical Sciences at Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, Sweden
    Knee Surg Sports Traumatol Arthrosc 19:1385-93. 2011
    ..The focus was to evaluate whether any improvements occurred between the one and 2-year evaluation...
  90. ncbi A biomechanical study of Achilles tendon repair augmentation using GraftJacket matrix
    F Alan Barber
    Plano Orthopedic and Sports Medicine Center, Sports Medicine, Plano, Texas 75093, USA
    Foot Ankle Int 29:329-33. 2008
    ..This study evaluated strength and stiffness of an Achilles tendon repair augmented with a human dermal allograft (GraftJacket)...
  91. ncbi Pathology of the torn rotator cuff tendon. Reduction in potential for repair as tear size increases
    T J W Matthews
    Nuffield Orthopaedic Centre, Windmill Road, Headington, Oxford OX3 7LD, UK
    J Bone Joint Surg Br 88:489-95. 2006
    ..Tissue from large and massive tears is of such a degenerative nature that it may be a significant cause of re-rupture after surgical repair and could make healing improbable in this group...
  92. ncbi Stepwise differentiation of human embryonic stem cells promotes tendon regeneration by secreting fetal tendon matrix and differentiation factors
    Xiao Chen
    Center for Stem Cells and Tissue Engineering, Institute of Cell Biology, School of Medicine, Zhejiang University, Hangzhou, China
    Stem Cells 27:1276-87. 2009
    ..Moreover, no teratoma was found in any samples. These findings demonstrate a safe and practical strategy of applying ESCs for tendon regeneration and may assist in future strategies to treat tendon diseases...
  93. ncbi Insulin-like growth factor-I improves cellular and molecular aspects of healing in a collagenase-induced model of flexor tendinitis
    Linda A Dahlgren
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Veterinary Medical Center, Ithaca, NY 14853, USA
    J Orthop Res 20:910-9. 2002
    ..Considered together with the decreased soft tissue swelling and improved sonographic healing, these data support the potential use of intralesional IGF-I for treatment of debilitating tendon injuries.
  94. ncbi Regenerative properties of fetal sheep tendon are not adversely affected by transplantation into an adult environment
    Michele Favata
    McKay Orthopaedic Research Laboratory, University of Pennsylvania, Philadelphia, Pennsylvania, and Center for Molecular Fetal Therapy, Cincinnati Children s Hospital, OH, USA
    J Orthop Res 24:2124-32. 2006
    b>Tendon injuries account for a significant number of musculoskeletal afflictions each year...
  95. ncbi Versican splice variant messenger RNA expression in normal human Achilles tendon and tendinopathies
    A N Corps
    Rheumatology Research Unit, Box 194, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Rheumatology (Oxford) 43:969-72. 2004
    ..Our objective was to define the expression of versican isoform splice variant messenger ribonucleic acid (mRNA) in normal Achilles tendons, in chronic painful tendinopathy and in ruptured tendons...
  96. ncbi Tissue engineering solutions for tendon repair
    MaCalus V Hogan
    University of Virginia Health System, Charlottesville, VA, USA
    J Am Acad Orthop Surg 19:134-42. 2011
    b>Tendon injuries range from acute traumatic ruptures and lacerations to chronic overuse injuries, such as tendinosis...
  97. ncbi Eccentric overload training for patients with chronic Achilles tendon pain--a randomised controlled study with reliability testing of the evaluation methods
    K G Silbernagel
    Sportrehab--Physical Therapy and Sports Medicine Clinic, , Sweden
    Scand J Med Sci Sports 11:197-206. 2001
    ..The measurement techniques and the treatment protocol with eccentric overload used in the present study can be recommended for patients with chronic pain from the Achilles tendon...
  98. ncbi The time for functional recovery after arthroscopic rotator cuff repair: correlation with tendon healing controlled by computed tomography arthrography
    Christophe Charousset
    AFTS Association Francilienne de Traumatologie Sportive, Clinique Bachaumont, Paris, France
    Arthroscopy 24:25-33. 2008
    ..We investigated how soon postoperative functional recovery became significant after arthroscopic rotator cuff repair and the influence of tendon healing...
  99. ncbi Evidence of tendon microtears due to cyclical loading in an in vivo tendinopathy model
    Leena H Nakama
    Joint Graduate Group in Bioengineering, University of California, Berkeley, CA, USA
    J Orthop Res 23:1199-205. 2005
    b>Tendon injuries at the epicondyle can occur in athletes and workers whose job functions involve repetitive, high force hand activities, but the early pathophysiologic changes of tendon are not well known...
  100. ncbi Effect of age on functional and structural outcome after rotator cuff repair
    Joo Han Oh
    Department of Orthopaedic Surgery, Seoul National University Hospital, 28 Yeongeon dong, Jongno gu, Seoul 110 744 Korea
    Am J Sports Med 38:672-8. 2010
    ..There are numerous reports on the outcome of rotator cuff repair according to age. However, the results are conflicting and driven by univariate analysis, which is not free of confounding factors...
  101. ncbi Basic biology of tendon injury and healing
    P Sharma
    Salisbury District Hospital, Wessex Deanery, UK
    Surgeon 3:309-16. 2005
    ..At present the aetiology of tendon disorders remains unclear, with several factors having been implicated. An improved understanding of tendon injury and healing is essential to enable focused treatment strategies to be devised...

Research Grants63

  1. ECM and MMPs in Muscle Atrophy and Rehabilitation
    Hubert Kim; Fiscal Year: 2011
    ..atrophy is a common complication following immobilization, nerve injury, and musculoskeletal trauma such as tendon injuries. Older patients are especially susceptible and are far less able to cope with the consequences...
  2. The Pathophysiology of Rotator Cuff Tendon Injury and Healing in the Presence of
    Stephen John Thomas; Fiscal Year: 2012
    ..Ultimately, this will provide physicians with further tools for efficiently treating patients with type II diabetes that are suffering from tendon injuries.
  3. REPAIR AND REHABILITATION OF FLEXOR TENDON INJURY
    Peter C Amadio; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Tendon injuries are common and often devastating, resulting in permanent loss of motion...
  4. Mature &Aging Tendons: Extracellular Matrix Interactions in the Injury Response
    Louis J Soslowsky; Fiscal Year: 2012
    ..potentially compensatory roles of these SLRPs that may aid in the design of improved treatment modalities for tendon injuries. In addition, defining the regulatory interactions involved in the regeneration of a functional tendon will ..
  5. ELECTROSPINNING ARTIFICIAL LIGAMENTS AND TENDONS FOR POTENTIAL PROSTHESES
    JAVIER MACOSSAY-TORRES; Fiscal Year: 2011
    ..To overcome current limitations on treating ligament and tendon injuries like a torn ACL, the long term research objective of this proposal is to develop artificial ligaments and ..
  6. Stimulation of tendon repair by retinoid nuclear receptor agonists
    Motomi Enomoto-Iwamoto; Fiscal Year: 2013
    ..In acute tendon injuries, repair is carried out by intrinsic tendon cells and extrinsic cells that migrate from surrounding tissues ..
  7. Ultrasonic analysis of the effects of aging on tendon mechanics
    Laura A Chernak; Fiscal Year: 2013
    ..Early detection of tendon injuries is extremely challenging, and end-stage treatments have limited success, often leading to a downward spiral ..
  8. Tendon Repair: Contributions of Progenitors and Small Leucine-Rich Proteoglycans
    Michael J Mienaltowski; Fiscal Year: 2012
    ..1), and specifically the healing response of Achilles tendon injuries will be examined in fibromodulin-deficient mice (Aim 3.2)...
  9. New Frontiers In Tendon Research
    Louis J Soslowsky; Fiscal Year: 2013
    ..Despite the prevalence of tendon injuries, therapeutic measures for effective intervention and prevention have progressed with limited success because ..
  10. Engineering Tendon Grafts for Better Outcomes
    Chunfeng Zhao; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: The restoration of normal hand function is crucial after flexor tendon injuries, and tendon reconstruction plays an important role to achieve this goal...
  11. A tissue specific approach to enhance tendon repair
    James H C Wang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Each year millions of Americans suffer from tendon injuries, resulting in impaired work performance and reduction in quality of life while costing billions of healthcare dollars in treatment...
  12. Growth Factor Coated Sutures for Improved Tendons Repair
    Paul Hamilton; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Tendon injuries are quite common and the frequency of these injuries is expected to rise as the population ages, yet continues to remain active...
  13. Bioadhesive Membrane Constructs to Augment Tendon Repair
    Bruce Lee; Fiscal Year: 2009
    The frequency with which tendon injuries are occurring is increasing due to medical advances that allow an increasingly aging population to remain physically active longer than previously possible...
  14. GDF5 MEDIATION OF TENDON HEALING
    Borjana Mikic; Fiscal Year: 2000
    ..such as the growth and differentiation factors (GDFs) represent a unique potential for the treatment of tendon injuries. To administer these agents effectively in a clinical setting, a complete understanding of their mechanisms ..
  15. Characterization of Tendon Damage Accumulation
    Vincent Wang; Fiscal Year: 2004
    b>Tendon injuries such as those of repetitive overuse and cumulative trauma (e.g., carpal tunnel syndrome) are a major source of pain and disability, yet the mechanism of low-level injury and progression of tendon pathology is unknown...
  16. An Accelerated Overuse Tendon Explant Injury Model
    Paul Weinhold; Fiscal Year: 2005
    ..loading in our accelerated overuse injury model and utilize the model to evaluate therapies for treating tendon injuries. The specific aims of the study are: 1...
  17. Functional tissue engineering of tendon
    Stavros Thomopoulos; Fiscal Year: 2003
    ..It is expected that a combination of structural and compositional design will be necessary to achieve the viscoelastic properties of normal tendon. ..
  18. Modified Hyaluronic Acid for Extrasynovial Tendon Graft
    Chunfeng Zhao; Fiscal Year: 2006
    Flexor tendon injuries affecting hand function are common in young adults, and frequently result in significant disability. Adhesion formation continues to be a difficult problem, which leads a poor outcome after flexor tendon repairs...
  19. IN VIVO MICROCT SYSTEM
    Matthew Silva; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  20. Robotic Simulation: Tissue Function with In Vivo Motions
    David Butler; Fiscal Year: 2007
    ..These technologies will serve as a platform for studying injury, repair and reconstruction in the knee and other joints and to develop functional tissue engineering parameters. [unreadable] [unreadable] [unreadable]..
  21. Stimulating Bone Formation using constrained Tibial Vibration
    Matthew Silva; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  22. Tissue Engineering Evaluation Criteria for Musculoskeletal Tissue Repair
    David Butler; Fiscal Year: 2007
    ..abstract_text> ..
  23. "In Vitro Mechanical Stimulation to Enhance Tendon Repair"
    David Butler; Fiscal Year: 2009
    ..large rotator cuff tears and augmenting ligament reconstructions;and repairing chronic degenerative tendon injuries. Using a functional tissue engineering or FTE roadmap with linked in vitro and in vivo studies, we will ..
  24. Cell phenotype-controlled mechanical signaling of MSCs
    David Butler; Fiscal Year: 2004
    ..This technology can dramatically reduce time/expense during the development phase of TE fibrocartilage. ..
  25. Basic Science of Tendon To Bone Healing
    Asheesh Bedi; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  26. The Interaction of Mechanical Load and Inflammation in Tendon-Bone Healing
    Scott A Rodeo; Fiscal Year: 2010
    ..The results of our studies will allow a scientific basis for the design of post- operative rehabilitation prescription. ..
  27. Tissue Engineering of Cartilage using Periosteum
    SHAWN O DRISCOLL; Fiscal Year: 2008
    ..In addition, by eliminating the need for cell culture expansion facilities and expertise, the cost of this approach should be considerably less thereby making cartilage repair more globally accessible. ..
  28. Cleveland Clinic Orthopaedic Research Training Grant
    JOSEPH IANNOTTI; Fiscal Year: 2008
    ..abstract_text> ..
  29. A role for intrinsic tendon cells in overuse injury
    Kathleen Derwin; Fiscal Year: 2005
    ..Most chronic tendon injuries and disorders are believed to start from repeated exposure to low-magnitude forces that 'injure' the tissue ..
  30. An interdisciplinary and integrative study of tendinopathy
    James H C Wang; Fiscal Year: 2010
    ....
  31. Effect of HA/receptor interaction in healing tendon
    PEDRO BEREDJIKLIAN; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  32. MECHANICAL FACTORS IN CARTILAGE REPAIR
    SHAWN O DRISCOLL; Fiscal Year: 2004
    ..It is felt that these findings will have relevance to other important area of orthopedics, including fracture healing, and have significant potential to impact the care of patients. ..
  33. MCL Healing: Interdisciplinary Studies
    Savio Woo; Fiscal Year: 2006
    ..The knowledge gained from this study will enhance the understanding of the mechanisms of ligament healing, which in turn, could be applied to aid in the healing of other ligaments (ACL) and tendons (flexor tendon). ..
  34. Clinically relevant large animal model of rotator cuff injury and repair
    Kathleen Derwin; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  35. A Request for support of 25th SPRSM Meeting
    James Wang; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  36. IN SITU FORCES IN NORMAL AND RECONSTRUCTED ACLS
    Savio Woo; Fiscal Year: 2005
    ..abstract_text> ..
  37. Adeno-associated virus for IGF-I cartilage gene therapy
    Alan Nixon; Fiscal Year: 2003
    ..abstract_text> ..
  38. Biomechanical Causes of Slow Gait in the Elderly
    DARRYL THELEN; Fiscal Year: 2006
    ..The results of this study are fundamental to the development of effective interventions that can improve gait function and thereby contribute to the maintenance of mobility in elderly adults [unreadable] [unreadable]..
  39. Biocomputation of the Links Between Muscle Morphology, Coordination and Injury
    DARRYL G contact THELEN; Fiscal Year: 2010
    ..This proposal couples novel biocomputational tools and imaging techniques to establish a scientific basis for preventing and rehabilitating hamstring muscle injuries. ..
  40. GTPase Activating Proteins in Aging and Osteoarthritis
    Lisa Fortier; Fiscal Year: 2007
    ..We anticipate that these findings will facilitate identification of target molecules for development of therapeutics modalities for OA. [unreadable] [unreadable] [unreadable]..
  41. INTRAOPERATIVE MEASUREMENT IN CEREBRAL PALSY SURGERY
    Richard Lieber; Fiscal Year: 2003
    ..In addition, these data will be relevant to management of other disorders such as stroke, head injury and spinal cord injury, where surgical tendon transfers are performed. ..
  42. Cell Recruitment Induced by ECM Scaffold Degradation
    Stephen F Badylak; Fiscal Year: 2010
    ..The objectives of the studies, the hypothesis upon which the experimental design is based, and a timeline for completion of the studies are presented. ..
  43. STRUCTURE/FUNCTION RELATIONSHIPS IN TENDON AND LIGAMENT
    LOUIS SOSLOWSKY; Fiscal Year: 2002
    ..It is suggested that completion of the studies outlined in the current proposal will provide an improved understanding of structure-function relationships in soft connective tissues. ..
  44. Mechanical Intervention in Children with Cerebral Palsy
    Tishya Wren; Fiscal Year: 2005
    ..This study will also provide insight into the potential role of muscle adaptation and bone turnover in increasing bone mass in response to this simple, non-invasive, non-pharmacalogical intervention. ..
  45. Prevention of Hip Dysplasia with Thermal Energy
    MANDI LOPEZ; Fiscal Year: 2005
    ..The University of Wisconsin provides an exceptional environment for interaction with experts in a variety of fields, and it is well known for its exceptional research programs, especially in the medical sciences. ..
  46. TENDON CELLS:INTERACTIONS & RESPONSES TO STRESS IN VITRO
    Albert Banes; Fiscal Year: 2004
    ..Knowledge of how motion acts at the mechanistic level may lead to drug strategies for upregulating cell division and matrix expression with or without motion in aged or disabled patients. ..
  47. MEDICAID MGD CARE FOR CHILDREN WITH SPEC HLTH CARE NEEDS
    JEAN MITCHELL; Fiscal Year: 2003
    ..abstract_text> ..
  48. Impact of Gait Analysis on Surgical Outcomes
    Tishya Wren; Fiscal Year: 2009
    ..The results will determine whether the use of gait analysis testing improves clinical outcomes in children who have walking problems due to cerebral palsy. ..
  49. Cutaneous Wound Repair with Transgenic Skin Cells in Pig
    Elof Eriksson; Fiscal Year: 2008
    ..These methodologies will help us understand and treat diabetic wounds. This constitutes a safe and practical system for in vivo gene delivery to skin wounds, offering therapeutic potential for other skin diseases. ..
  50. A RENEW Intervention for Elderly Cancer Survivors
    Paul Lastayo; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  51. Enhancing Recovery of Muscle after Rotator Cuff Repair
    Elisabeth Barton; Fiscal Year: 2006
    ..Ultimately, the goal the of proposed study is to develop appropriate therapeutic strategies for the treatment of rotator cuff injury. ..
  52. ORIGIN OF CELLS THAT REPOPULATE RESORBABLE ECM SCAFFOLDS
    Stephen Badylak; Fiscal Year: 2001
    ..abstract_text> ..
  53. Cellular Remodeling of ECM Scaffolds
    Stephen Badylak; Fiscal Year: 2009
    ..We have identified clearly defined specific aims with quantifiable end points and an efficient three year timeline to conduct this work. ..
  54. Direct Determination of Lower Extremity of Muscle Design
    Richard Lieber; Fiscal Year: 2009
    ..This data, once available to the biomechanical community will propel this field to the next level and enable development of meaningful new surgical procedures and objective methods of evaluating human musculoskeletal function. ..
  55. Bioreactor for Engineered Bioartificial Tissues (BATS)
    Albert Banes; Fiscal Year: 2005
    ..Expansion to a larger bioreactor chamber will allow biomedical researchers to develop better strategies for growth and testing of scaled up tissues for use in vivo in numerous connective tissue applications. ..
  56. Mentored Patient-Oriented Research Career Development Award
    Martin Torriani; Fiscal Year: 2008
    ..abstract_text> ..
  57. GDF Modulation of Tendon Maintenance and Repair
    Borjana Mikic; Fiscal Year: 2008
    ..factors such as the growth/differentiation factors (GDFs) represent a unique potential for the treatment of tendon injuries. To administer these agents effectively in a clinical setting, a complete understanding of their mechanisms ..
  58. Tendon Strains in Rotator Cuff Injury/Repair Using MRI
    LOUIS SOSLOWSKY; Fiscal Year: 2007
    ..abstract_text> ..
  59. ETIOLOGIC FACTORS FOR TENDON DEGENERATION
    LOUIS SOSLOWSKY; Fiscal Year: 2004
    ..We will rigorously evaluate our resulting specific testable hypothesis via biomechanical, histologic, biochemical, and molecular biologic assays of rotator cuff tendons. ..
  60. CCD detector
    Carol Muehleman; Fiscal Year: 2005
    ..Additionally, the optimized facility will greatly enhance the productivity of each user group as a consequence of detector efficiency. ..
  61. NOVEL X-RAY TECHNOLOGY FOR DEGENERATIVE JOINT DISEASE
    Carol Muehleman; Fiscal Year: 2006
    ..Our long-term goal is to identify and localize initial phases of cartilage degeneration and follow their progression with the ultimate aim of monitoring disease progression and therapeutic interventions. ..
  62. GDF REGULATION OF ENDOCHONDRAL BONE GROWTH
    Borjana Mikic; Fiscal Year: 2002
    ....