radiation injuries

Summary

Summary: Harmful effects of non-experimental exposure to ionizing or non-ionizing radiation in chordates.

Top Publications

  1. pmc Stereotactic body radiotherapy for organ-confined prostate cancer
    Alan J Katz
    Winthrop University Hospital, 264 Old Country Road, Mineola, NY 11501, USA
    BMC Urol 10:1. 2010
  2. ncbi Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial
    Eric L Chang
    Department of Radiation Oncology, The University of Texas, M D Anderson Cancer Center, Houston, TX, USA
    Lancet Oncol 10:1037-44. 2009
  3. ncbi Intensity-modulated radiation therapy, protons, and the risk of second cancers
    Eric J Hall
    Center for Radiological Research, Columbia University Medical Center, College of Physicians and Surgeons, New York, NY 10032, USA
    Int J Radiat Oncol Biol Phys 65:1-7. 2006
  4. pmc Use of normal tissue complication probability models in the clinic
    Lawrence B Marks
    Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC 27514, USA
    Int J Radiat Oncol Biol Phys 76:S10-9. 2010
  5. ncbi Incidence of late rectal and urinary toxicities after three-dimensional conformal radiotherapy and intensity-modulated radiotherapy for localized prostate cancer
    Michael J Zelefsky
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Int J Radiat Oncol Biol Phys 70:1124-9. 2008
  6. ncbi Radiation-associated liver injury
    Charlie C Pan
    Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI 48109 5010, USA
    Int J Radiat Oncol Biol Phys 76:S94-100. 2010
  7. ncbi Hypofractionated intensity-modulated radiotherapy (70 Gy at 2.5 Gy per fraction) for localized prostate cancer: Cleveland Clinic experience
    Patrick A Kupelian
    Department of Radiation Oncology, M D Anderson Cancer Center Orlando, Orlando, FL 32806, USA
    Int J Radiat Oncol Biol Phys 68:1424-30. 2007
  8. ncbi Phase I study of individualized stereotactic body radiotherapy for hepatocellular carcinoma and intrahepatic cholangiocarcinoma
    Regina V Tse
    Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    J Clin Oncol 26:657-64. 2008
  9. ncbi Stereotactic body radiotherapy for patients with unresectable primary hepatocellular carcinoma: dose-volumetric parameters predicting the hepatic complication
    Seok Hyun Son
    Department of Radiation Oncology, College of Medicine, Catholic University of Korea, Seoul, Korea
    Int J Radiat Oncol Biol Phys 78:1073-80. 2010
  10. ncbi Long-term mortality from heart disease and lung cancer after radiotherapy for early breast cancer: prospective cohort study of about 300,000 women in US SEER cancer registries
    Sarah C Darby
    Clinical Trial Service Unit, University of Oxford, Oxford, UK
    Lancet Oncol 6:557-65. 2005

Detail Information

Publications303 found, 100 shown here

  1. pmc Stereotactic body radiotherapy for organ-confined prostate cancer
    Alan J Katz
    Winthrop University Hospital, 264 Old Country Road, Mineola, NY 11501, USA
    BMC Urol 10:1. 2010
    ..We present preliminary results following stereotactic body radiotherapy (SBRT) treatment for organ-confined prostate cancer...
  2. ncbi Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial
    Eric L Chang
    Department of Radiation Oncology, The University of Texas, M D Anderson Cancer Center, Houston, TX, USA
    Lancet Oncol 10:1037-44. 2009
    ..We proposed that the learning and memory functions of patients who undergo SRS plus WBRT are worse than those of patients who undergo SRS alone. We did a randomised controlled trial to test our prediction...
  3. ncbi Intensity-modulated radiation therapy, protons, and the risk of second cancers
    Eric J Hall
    Center for Radiological Research, Columbia University Medical Center, College of Physicians and Surgeons, New York, NY 10032, USA
    Int J Radiat Oncol Biol Phys 65:1-7. 2006
    ..The benefit of protons is only achieved if a scanning beam is used in which the doses are 10 times lower than with IMRT...
  4. pmc Use of normal tissue complication probability models in the clinic
    Lawrence B Marks
    Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC 27514, USA
    Int J Radiat Oncol Biol Phys 76:S10-9. 2010
    ..A summary of organ-specific dose/volume/outcome data, based on the QUANTEC reviews, is included...
  5. ncbi Incidence of late rectal and urinary toxicities after three-dimensional conformal radiotherapy and intensity-modulated radiotherapy for localized prostate cancer
    Michael J Zelefsky
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Int J Radiat Oncol Biol Phys 70:1124-9. 2008
    ..To report the incidence and predictors of treatment-related toxicity at 10 years after three-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT) for localized prostate cancer...
  6. ncbi Radiation-associated liver injury
    Charlie C Pan
    Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI 48109 5010, USA
    Int J Radiat Oncol Biol Phys 76:S94-100. 2010
    ..This article describes the endpoints, time-course, and dose-volume effect of radiation on the liver...
  7. ncbi Hypofractionated intensity-modulated radiotherapy (70 Gy at 2.5 Gy per fraction) for localized prostate cancer: Cleveland Clinic experience
    Patrick A Kupelian
    Department of Radiation Oncology, M D Anderson Cancer Center Orlando, Orlando, FL 32806, USA
    Int J Radiat Oncol Biol Phys 68:1424-30. 2007
    ..To study the outcomes in patients treated for localized prostate cancer with 70 Gy delivered at 2.5-Gy/fraction within 5 weeks...
  8. ncbi Phase I study of individualized stereotactic body radiotherapy for hepatocellular carcinoma and intrahepatic cholangiocarcinoma
    Regina V Tse
    Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    J Clin Oncol 26:657-64. 2008
    ..To report outcomes of a phase I study of individualized stereotactic body radiotherapy treatment (SBRT) for unresectable hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (IHC)...
  9. ncbi Stereotactic body radiotherapy for patients with unresectable primary hepatocellular carcinoma: dose-volumetric parameters predicting the hepatic complication
    Seok Hyun Son
    Department of Radiation Oncology, College of Medicine, Catholic University of Korea, Seoul, Korea
    Int J Radiat Oncol Biol Phys 78:1073-80. 2010
    ..To identify the parameters that predict hepatic toxicity and deterioration of hepatic function...
  10. ncbi Long-term mortality from heart disease and lung cancer after radiotherapy for early breast cancer: prospective cohort study of about 300,000 women in US SEER cancer registries
    Sarah C Darby
    Clinical Trial Service Unit, University of Oxford, Oxford, UK
    Lancet Oncol 6:557-65. 2005
    ..This study aimed to assess the hazards in the general US population from routine cancer-registry and death-certificate data...
  11. pmc Radiation dose-volume effects in radiation-induced rectal injury
    Jeff M Michalski
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 76:S123-9. 2010
    ..It is possible that intensity-modulated radiotherapy or proton beam dose distributions require modification of these models because of the inherent differences in low and intermediate dose distributions...
  12. ncbi Evolution of radiation-induced brain injury: MR imaging-based study
    Yi Xiang J Wang
    Department of Diagnostic Radiology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, People s Republic of China
    Radiology 254:210-8. 2010
    ..To evaluate the temporal lobes in patients previously treated for nasopharyngeal carcinoma to provide a better understanding of delayed radiation-induced injury in the brain unaffected by the underlying tumor...
  13. ncbi Independent validation of genes and polymorphisms reported to be associated with radiation toxicity: a prospective analysis study
    Gillian C Barnett
    University of Cambridge, Department of Oncology, Cambridge, UK
    Lancet Oncol 13:65-77. 2012
    ..Few associations have been tested in independent validation studies. This prospective study aimed to validate reported associations between genotype and radiation toxicity in a large independent dataset...
  14. ncbi Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: a randomized controlled trial
    Hidefumi Aoyama
    Departments of Radiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    JAMA 295:2483-91. 2006
    ..In patients with brain metastases, it is unclear whether adding up-front whole-brain radiation therapy (WBRT) to stereotactic radiosurgery (SRS) has beneficial effects on mortality or neurologic function compared with SRS alone...
  15. ncbi Medical management of the acute radiation syndrome: recommendations of the Strategic National Stockpile Radiation Working Group
    Jamie K Waselenko
    Walter Reed Army Medical Center and Catholic University of America, Washington, DC 20307, USA
    Ann Intern Med 140:1037-51. 2004
    ..for physicians in internal medicine and the medical subspecialties to evaluate and manage large-scale radiation injuries. Individual radiation dose is assessed by determining the time to onset and severity of nausea and vomiting, ..
  16. pmc Hippocampal-sparing whole-brain radiotherapy: a "how-to" technique using helical tomotherapy and linear accelerator-based intensity-modulated radiotherapy
    Vinai Gondi
    Department of Human Oncology, University of Wisconsin Comprehensive Cancer Center, Madison, WI 53792, USA
    Int J Radiat Oncol Biol Phys 78:1244-52. 2010
    ..Herein we report our preliminary experience with whole-brain radiotherapy using hippocampal sparing for patients with brain metastases...
  17. ncbi Protection against ionizing radiation by antioxidant nutrients and phytochemicals
    Joseph F Weiss
    Office of Health Studies, US Department of Energy, EH 6 270 Corporate Square, 1000 Independence Avenue, SW, Washington, DC 20585 0270, USA
    Toxicology 189:1-20. 2003
    ..In addition, further studies are required to determine the potential value of specific antioxidant nutrients and phytochemicals during radiotherapy for cancer...
  18. ncbi Preventing or reducing late side effects of radiation therapy: radiobiology meets molecular pathology
    Søren M Bentzen
    University of Wisconsin School of Medicine and Public Health, Department of Human Oncology, K4 316 Clinical Science Center, 600 Highland Avenue, Madison, Wisconsin 53792, USA
    Nat Rev Cancer 6:702-13. 2006
    ..This stimulates research into new pharmacological strategies for preventing or reducing the side effects of radiation therapy...
  19. pmc Radiation induced temporal lobe necrosis in patients with nasopharyngeal carcinoma: a review of new avenues in its management
    Jing Chen
    Cancer Centre, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Radiat Oncol 6:128. 2011
    ....
  20. ncbi Radiation-induced liver disease in three-dimensional conformal radiation therapy for primary liver carcinoma: the risk factors and hepatic radiation tolerance
    Shi xiong Liang
    Department of Radiation Oncology, Fudan University Cancer Hospital, Shanghai, China
    Int J Radiat Oncol Biol Phys 65:426-34. 2006
    ..To identify risk factors relevant to radiation-induced liver disease (RILD) and to determine the hepatic tolerance to radiation...
  21. ncbi Clinical features, mechanisms, and management of pseudoprogression in malignant gliomas
    Dieta Brandsma
    Department of Neuro Oncology, Daniel den Hoed Cancer Centre, Erasmus Medical Centre, Rotterdam, Netherlands
    Lancet Oncol 9:453-61. 2008
    ..Further research is needed to establish reliable imaging parameters that distinguish between true tumour progression and pseudoprogression or treatment-related necrosis...
  22. pmc Quantitative Analyses of Normal Tissue Effects in the Clinic (QUANTEC): an introduction to the scientific issues
    Søren M Bentzen
    Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Int J Radiat Oncol Biol Phys 76:S3-9. 2010
    ..Research priorities for the next 5-10 years are proposed...
  23. pmc Randomized double-blind placebo-controlled trial of bevacizumab therapy for radiation necrosis of the central nervous system
    Victor A Levin
    Department of Neuro Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77230 1402, USA
    Int J Radiat Oncol Biol Phys 79:1487-95. 2011
    ..To conduct a controlled trial of bevacizumab for the treatment of symptomatic radiation necrosis of the brain...
  24. ncbi Major radiation exposure--what to expect and how to respond
    Fred A Mettler
    Department of Radiology, University of New Mexico Health Sciences Center, Albuquerque 87131, USA
    N Engl J Med 346:1554-61. 2002
  25. pmc p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis
    David G Kirsch
    David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 327:593-6. 2010
    ..These results suggest that the GI syndrome is caused by the death of GI epithelial cells and that these epithelial cells die by a mechanism that is regulated by p53 but independent of apoptosis...
  26. ncbi Effect of bevacizumab on radiation necrosis of the brain
    Javier Gonzalez
    Department of Neuro Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1402, USA
    Int J Radiat Oncol Biol Phys 67:323-6. 2007
    ..Because blocking vascular endothelial growth factor (VEGF) from reaching leaky capillaries is a logical strategy for the treatment of radiation necrosis, we reasoned that bevacizumab might be an effective treatment of radiation necrosis...
  27. pmc Targeting the TGF-beta1 pathway to prevent normal tissue injury after cancer therapy
    Mitchell S Anscher
    Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia, USA
    Oncologist 15:350-9. 2010
    ....
  28. ncbi Reirradiation tolerance of the human brain
    Ramona Mayer
    Department of Therapeutic Radiology and Oncology, Medical University of Graz, Graz, Austria
    Int J Radiat Oncol Biol Phys 70:1350-60. 2008
    ..To give an overview of current available clinical data on reirradiation of glioma with respect to the tolerance dose of normal brain tissue...
  29. ncbi TGF-beta1 and radiation fibrosis: a master switch and a specific therapeutic target?
    M Martin
    Laboratoire de Radiobiologie et d Etude du Génome, DRR, DSV, C E A, Saclay, France
    Int J Radiat Oncol Biol Phys 47:277-90. 2000
    ....
  30. ncbi Molecular and cellular biology of moderate-dose (1-10 Gy) radiation and potential mechanisms of radiation protection: report of a workshop at Bethesda, Maryland, December 17-18, 2001
    C Norman Coleman
    Radiation Oncology Sciences Program, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    Radiat Res 159:812-34. 2003
    ..The resulting radiation injuries would be due to a series of molecular, cellular, tissue and whole-animal processes...
  31. ncbi Effect of amifostine on survival among patients treated with radiotherapy: a meta-analysis of individual patient data
    Jean Bourhis
    Institut Gustave Roussy, 114 rue Edouard Vaillant, 94805 Villejuif Cedex, France
    J Clin Oncol 29:2590-7. 2011
    ..The aim of this meta-analysis was to evaluate the impact of amifostine on overall survival (OS) and progression-free survival (PFS) in patients treated with radiotherapy or chemoradiotherapy...
  32. ncbi Spatial learning and memory deficits after whole-brain irradiation are associated with changes in NMDA receptor subunits in the hippocampus
    Lei Shi
    Department of Neurobiology and Anatomy, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    Radiat Res 166:892-9. 2006
    ..These findings suggest for the first time that radiation-induced cognitive impairments may be associated with alterations in glutamate receptor composition...
  33. ncbi Intensity-modulated radiotherapy reduces gastrointestinal toxicity in patients treated with androgen deprivation therapy for prostate cancer
    Navesh K Sharma
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Radiat Oncol Biol Phys 80:437-44. 2011
    ..The present study compared the genitourinary and gastrointestinal (GI) toxicity in men treated with 3D-CRT+AD vs. IMRT+AD...
  34. ncbi Initial experience with bevacizumab treatment for biopsy confirmed cerebral radiation necrosis
    Roy Torcuator
    Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Hospital, 2799 W Grand Blvd, Detroit, MI 48202, USA
    J Neurooncol 94:63-8. 2009
    ..We retrospectively reviewed 6 patients with biopsy proven cerebral radiation necrosis treated with bevacizumab between 2006 and 2008...
  35. ncbi Dose-volumetric parameters predicting radiation-induced hepatic toxicity in unresectable hepatocellular carcinoma patients treated with three-dimensional conformal radiotherapy
    Tae Hyun Kim
    Research Institute and Hospital, National Cancer Center, Goyang, Republic of Korea
    Int J Radiat Oncol Biol Phys 67:225-31. 2007
    ..To identify the dose-volumetric parameters associated with the risk of radiation-induced hepatic toxicity (RIHT) in hepatocellular carcinoma patients treated with three-dimensional conformal radiotherapy...
  36. ncbi Chronic oxidative stress and radiation-induced late normal tissue injury: a review
    M E C Robbins
    Departments of Radiation Oncology and Neurosurgery, Brain Tumor Center of Excellence, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Int J Radiat Biol 80:251-9. 2004
    ..This mini-review presents data to support this hypothesis and provides the foundation for antioxidant-based interventional approaches directed at modulating late normal tissue injury...
  37. ncbi Radiation-associated cardiovascular disease
    M Jacob Adams
    Department of Pediatrics, Division of Pediatric Cardiology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 631, Rochester, NY 14642, USA
    Crit Rev Oncol Hematol 45:55-75. 2003
    ..Long-term cardiac follow-up of these patients is therefore essential, and the range of appropriate cardiac screening is discussed, although no specific, evidence-based screening regimen was found in the literature...
  38. ncbi Diabetes mellitus: a predictor for late radiation morbidity
    D M Herold
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
    Int J Radiat Oncol Biol Phys 43:475-9. 1999
    ....
  39. ncbi Correlation of smoking history and other patient characteristics with major complications of pelvic radiation therapy for cervical cancer
    Patricia J Eifel
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 20:3651-7. 2002
    ..The purpose of this study was to identify patient-related factors that influence the risk of serious late complications of pelvic radiation therapy...
  40. ncbi Priority list of research areas for radiological nuclear threat countermeasures
    Terry C Pellmar
    Armed Forces Radiobiology Research Institute, Uniformed Services University, Bethesda, Maryland 20889 5603, USA
    Radiat Res 163:115-23. 2005
    ....
  41. ncbi Defining the risk of developing grade 2 proctitis following 125I prostate brachytherapy using a rectal dose-volume histogram analysis
    K M Snyder
    Department of Radiation Oncology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Int J Radiat Oncol Biol Phys 50:335-41. 2001
    ..Delivered dose should be kept below defined rectal volume thresholds to minimize this risk. This information can allow one to decrease rectal morbidity by modifying prostate implant technique...
  42. pmc Radioprotectors and mitigators of radiation-induced normal tissue injury
    Deborah Citrin
    Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Oncologist 15:360-71. 2010
    ..Few agents are approved for clinical use, but many new compounds show promising results in preclinical testing...
  43. pmc Phase III pilot study of dose escalation using conformal radiotherapy in prostate cancer: PSA control and side effects
    D P Dearnaley
    Academic Department of Radiotherapy and Oncology, Institute of Cancer Research, Sutton, Surrey SM2 5PT, UK
    Br J Cancer 92:488-98. 2005
    ..Data from this randomised pilot study informed the Data Monitoring Committee of the Medical Research Council RT 01 Trial and the two studies will be combined in subsequent meta-analysis...
  44. doi An overview of hypofractionation and introduction to this issue of seminars in radiation oncology
    Robert D Timmerman
    Semin Radiat Oncol 18:215-22. 2008
  45. ncbi Noncancer disease incidence in atomic bomb survivors, 1958-1998
    Michiko Yamada
    Department of Clinical Studies, Radiation Effects Research Foundation, Hiroshima, Japan
    Radiat Res 161:622-32. 2004
    ..These results attest to the need for continued follow-up of the aging A-bomb survivors to fully elucidate the effects of radiation exposure on the occurrence of noncancer diseases...
  46. pmc Protective role of R-spondin1, an intestinal stem cell growth factor, against radiation-induced gastrointestinal syndrome in mice
    Payel Bhanja
    Department of Radiation Oncology, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 4:e8014. 2009
    ....
  47. pmc Radiation exposure and circulatory disease risk: Hiroshima and Nagasaki atomic bomb survivor data, 1950-2003
    Yukiko Shimizu
    Department of Epidemiology, Radiation Effects Research Foundation, 5 2 Hijiyama Park, Minami Ku, Hiroshima 732 0815, Japan
    BMJ 340:b5349. 2010
    ..To investigate the degree to which ionising radiation confers risk of mortality from heart disease and stroke...
  48. ncbi Stereotactic body radiotherapy for localized prostate cancer: interim results of a prospective phase II clinical trial
    Christopher R King
    Department of Radiation Oncology, Division of Urologic Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Int J Radiat Oncol Biol Phys 73:1043-8. 2009
    ..The radiobiology of prostate cancer favors a hypofractionated dose regimen. We report results of a prospective Phase II clinical trial of stereotactic body radiotherapy (SBRT) for localized prostate cancer...
  49. ncbi Role of intensity-modulated radiotherapy in reducing toxicity in dose escalation for localized prostate cancer
    Abrahim Al-Mamgani
    Department of Radiation Oncology, Erasmus Medical Center Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 73:685-91. 2009
    ....
  50. ncbi Comparison of heart and coronary artery doses associated with intensity-modulated radiotherapy versus three-dimensional conformal radiotherapy for distal esophageal cancer
    Thomas P Kole
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Int J Radiat Oncol Biol Phys 83:1580-6. 2012
    ..four-field three-dimensional conformal radiotherapy (3D-CRT) treatment plans for patients with distal esophageal cancer undergoing chemoradiation...
  51. ncbi Malignant gliomas: MR imaging spectrum of radiation therapy- and chemotherapy-induced necrosis of the brain after treatment
    A J Kumar
    Division of Diagnostic Imaging, University of Texas M D Anderson Cancer Center, Box 57, Houston, TX 77030, USA
    Radiology 217:377-84. 2000
    ..To describe both the common and less frequently encountered magnetic resonance (MR) imaging features of radiation therapy- and chemotherapy-induced brain injury, with particular emphasis on radiation necrosis...
  52. ncbi Intensity-modulated radiotherapy for sinonasal cancer: improved outcome compared to conventional radiotherapy
    Piet Dirix
    Department of Radiation Oncology, Leuvens Kankerinstituut LKI, University Hospitals Leuven, Campus Gasthuisberg, Leuven, Belgium
    Int J Radiat Oncol Biol Phys 78:998-1004. 2010
    ..To evaluate clinical outcome and toxicity of postoperative intensity-modulated radiotherapy (IMRT) for malignancies of the nasal cavity and paranasal sinuses...
  53. pmc Pentoxifylline enhances the radioprotective properties of γ-tocotrienol: differential effects on the hematopoietic, gastrointestinal and vascular systems
    Maaike Berbee
    Division of Radiation Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Radiat Res 175:297-306. 2011
    ..GT3+PTX did not reduce GI toxicity or vascular oxidative stress compared to GT3 alone. The radioprotective effect of either drug alone or both drugs in combination does not require the presence of eNOS...
  54. ncbi Postradiation nasopharyngeal necrosis in the patients with nasopharyngeal carcinoma
    Yi Jun Hua
    State Key Laboratory of Oncology in Southern China, Guangzhou, China
    Head Neck 31:807-12. 2009
    ..However, the analysis of PRNN with a significant cohort of patients has not been reported in English-language literature. In this study, we aimed to evaluate PRNN in 28 patients with NPC...
  55. ncbi Whole brain radiotherapy with hippocampal avoidance and simultaneous integrated boost for 1-3 brain metastases: a feasibility study using volumetric modulated arc therapy
    Fred Hsu
    Vancouver Centre, Department of Radiation Oncology, BC Cancer Agency, British Columbia, Canada
    Int J Radiat Oncol Biol Phys 76:1480-5. 2010
    ..To evaluate the feasibility of using volumetric modulated arc therapy (VMAT) to deliver whole brain radiotherapy (WBRT) with hippocampal avoidance and a simultaneous integrated boost (SIB) for one to three brain metastases...
  56. ncbi Effects of radiation on normal tissue: consequences and mechanisms
    Helen B Stone
    Radiation Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, NIH, MD 20892 7440, USA
    Lancet Oncol 4:529-36. 2003
    ..Treatments that reduce the risk or severity of damage to normal tissue or that facilitate the healing of radiation injury are being developed. These could greatly improve the quality of life of patients treated for cancer...
  57. ncbi Radiation-induced lung injury. Assessment, management, and prevention
    Paiman Ghafoori
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Oncology (Williston Park) 22:37-47; discussion 52-3. 2008
    ..New modalities such as intensity-modulated radiation therapy and stereotactic body radiation therapy provide new treatment options but also pose new challenges in safely delivering thoracic RT...
  58. ncbi Radiation-induced rib fractures after hypofractionated stereotactic body radiation therapy of non-small cell lung cancer: a dose- and volume-response analysis
    Niclas Pettersson
    Department of Radiophysics, Sahlgrenska University Hospital, Sweden
    Radiother Oncol 91:360-8. 2009
    ..The aim of this study is to analyse the dose-response and the volume-response of radiation-induced rib fractures after hypofractionated stereotactic body radiation therapy (SBRT)...
  59. ncbi Three-dimensional conformal radiation therapy for squamous cell carcinoma of the esophagus: a prospective phase I/II study
    Kai liang Wu
    Department of Radiation Oncology, Fudan University Shanghai Cancer Hospital, Shanghai, PR China
    Radiother Oncol 93:454-7. 2009
    ..A prospective phase I-II study was conducted to determine the tolerance and local control rate of three-dimensional conformal radiotherapy (3-DCRT) for esophageal squamous cell carcinoma (SCC)...
  60. ncbi Acute toxicity of curative radiotherapy for intermediate- and high-risk localised prostate cancer in the EORTC trial 22991
    O Matzinger
    EORTC Headquarters, Belgium
    Eur J Cancer 45:2825-34. 2009
    ..We report acute toxicity (CTCAE v2) assessed weekly during RT in relation to radiation parameters...
  61. ncbi Late radiation-induced heart disease after radiotherapy. Clinical importance, radiobiological mechanisms and strategies of prevention
    Nicolaus Andratschke
    Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie, Technische Universitat Munchen, Munich, Germany
    Radiother Oncol 100:160-6. 2011
    ....
  62. ncbi Radiation dose-volume effects in the stomach and small bowel
    Brian D Kavanagh
    Department of Radiation Oncology, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
    Int J Radiat Oncol Biol Phys 76:S101-7. 2010
    ..Concurrent chemotherapy has been associated with a higher risk of acute toxicity, and a history of abdominal surgery has been associated with a higher risk of late toxicity...
  63. pmc Estimation of α/β for late rectal toxicity based on RTOG 94-06
    Susan L Tucker
    Department of Bioinformatics and Computational Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1402, USA
    Int J Radiat Oncol Biol Phys 81:600-5. 2011
    ....
  64. ncbi Review of the cardiac long-term effects of therapy for Hodgkin lymphoma
    Andrea K Ng
    Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Br J Haematol 154:23-31. 2011
    ..Screening for and aggressive management of traditional cardiac risk factors are also important strategies in reducing risks of cardiac disease in long-term Hodgkin lymphoma survivors...
  65. ncbi Sparing of the hippocampus, limbic circuit and neural stem cell compartment during partial brain radiotherapy for glioma: a dosimetric feasibility study
    James C Marsh
    Department of Radiation Oncology, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Med Imaging Radiat Oncol 55:442-9. 2011
    ..The aim of this study was to assess the feasibility of sparing contralateral or bilateral neural stem cell (NSC) compartment, hippocampus and limbic circuit during partial brain radiotherapy (PBRT)...
  66. pmc Treatment and prognosis of patients with late rectal bleeding after intensity-modulated radiation therapy for prostate cancer
    Shinya Takemoto
    Department of Radiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Radiat Oncol 7:87. 2012
    ..We evaluated the results of treatment for hemorrhagic proctitis after IMRT for prostate cancer...
  67. ncbi A randomized prospective study of rehabilitation therapy in the treatment of radiation-induced dysphagia and trismus
    Y Tang
    Department of Neurology, Sun Yat Sen Memorial Hospital, Sun Yat Sen University, Guangzhou, China
    Strahlenther Onkol 187:39-44. 2011
    ..To evaluate the therapeutic effect of rehabilitation therapy on radiation-induced dysphagia and trismus in nasopharyngeal carcinoma (NPC) patients after radiotherapy...
  68. ncbi A dosimetric model of duodenal toxicity after stereotactic body radiotherapy for pancreatic cancer
    James D Murphy
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305 5152, USA
    Int J Radiat Oncol Biol Phys 78:1420-6. 2010
    ..The duodenum is generally considered to be the organ at greatest risk. This study reports on the dosimetric determinants of duodenal toxicity with single-fraction SBRT...
  69. ncbi Stereotactic body radiotherapy for medically inoperable lung cancer: prospective, single-center study of 108 consecutive patients
    Mojgan Taremi
    Radiation Medicine Program, Princess Margaret Hospital, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 82:967-73. 2012
    ..To present the results of stereotactic body radiotherapy (SBRT) for medically inoperable patients with Stage I non-small-cell lung cancer (NSCLC) and contrast outcomes in patients with and without a pathologic diagnosis...
  70. pmc A model of cardiovascular disease giving a plausible mechanism for the effect of fractionated low-dose ionizing radiation exposure
    Mark P Little
    Department of Epidemiology and Public Health, Faculty of Medicine, Imperial College London, London, United Kingdom
    PLoS Comput Biol 5:e1000539. 2009
    ..The analysis of the present paper suggests that linear extrapolation would be appropriate for this endpoint...
  71. pmc Pregnancy outcome after treatment for Wilms tumor: a report from the national Wilms tumor long-term follow-up study
    Daniel M Green
    Department of Epidemiology and Cancer Control, St Jude Children s Research Hospital, 262 Danny Thomas Way, Mail Stop 735, Memphis, TN 38105 2794, USA
    J Clin Oncol 28:2824-30. 2010
    ....
  72. ncbi Transperineal injection of hyaluronic acid in anterior perirectal fat to decrease rectal toxicity from radiation delivered with intensity modulated brachytherapy or EBRT for prostate cancer patients
    Pedro J Prada
    Department of Radiation Oncology, Hospital Central de Asturias, Oviedo, Spain
    Int J Radiat Oncol Biol Phys 69:95-102. 2007
    ..We began an investigational trial injecting hyaluronic acid (HA) in the perirectal fat to increase the distance between the prostate and the anterior rectal wall. This is the first report using HA injection in oncology...
  73. ncbi Sparing of the neural stem cell compartment during whole-brain radiation therapy: a dosimetric study using helical tomotherapy
    James C Marsh
    Department of Radiation Oncology, Rush University Medical Center, Chicago, Illinois 60612, USA
    Int J Radiat Oncol Biol Phys 78:946-54. 2010
    ..To assess the feasibility of dosimetrically sparing the hippocampus and neural stem cell (NSC) compartment during whole-brain radiotherapy (WBRT) and prophylactic cranial irradiation (PCI)...
  74. ncbi Functional outcomes and complications following radiation therapy for prostate cancer: a critical analysis of the literature
    Lars Budaus
    Martini Clinic Prostate Cancer Centre, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Eur Urol 61:112-27. 2012
    ..The selection of the optimal RT treatment for the individual is still a point of discussion, and the debate centres on two important outcomes-namely, cancer control and reduction of side-effects...
  75. ncbi Radiotherapy for 41 patients with stages I and II MALT lymphoma: a retrospective study
    Hideomi Yamashita
    Department of Radiology, University of Tokyo Hospital, Hongo, Bunkyo ku, Tokyo, Japan
    Radiother Oncol 87:412-7. 2008
    ..We analyzed our recent experience with Stage I/II MALT lymphoma presenting in the stomach and other organs to assess the outcome following radiation therapy (RT) alone...
  76. pmc A further comparison of pathologies after thoracic irradiation among different mouse strains: finding the best preclinical model for evaluating therapies directed against radiation-induced lung damage
    Isabel L Jackson
    Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA
    Radiat Res 175:510-18. 2011
    ..C57L mice are particularly relevant in that they show significant lung damage at lower radiation doses that are closer to what is predicted for humans...
  77. ncbi Treatment outcomes and late complications of 849 patients with nasopharyngeal carcinoma treated with radiotherapy alone
    Shyh An Yeh
    Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, Taiwan
    Int J Radiat Oncol Biol Phys 62:672-9. 2005
    ..The objective of this study was to describe the treatment outcomes and treatment-related complications of nasopharyngeal carcinoma (NPC) patients treated with radiotherapy alone...
  78. ncbi Medical radiation exposure in the U.S. in 2006: preliminary results
    Fred A Mettler
    Radiology and Nuclear Medicine Service, New Mexico VA Health Care System, Albuquerque, NM 87108, USA
    Health Phys 95:502-7. 2008
    ..Nuclear medicine accounted for about 4% of all procedures but 26% of the total collective dose. Medical radiation exposure is now approximately equal to natural background radiation...
  79. ncbi Comparison of three different mediastinal radiotherapy techniques in female patients: Impact on heart sparing and dose to the breasts
    Carsten Nieder
    Department of Radiation Oncology, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich, Germany
    Radiother Oncol 82:301-7. 2007
    ..Especially in highly curable diseases such as lymphoma, long-term survivors might develop late cardiac damage and radiation-induced second cancer...
  80. ncbi Critical appraisal of volumetric modulated arc therapy in stereotactic body radiation therapy for metastases to abdominal lymph nodes
    Mario Bignardi
    Istituto Clinico Humanitas, Radiation Oncology, Rozzano, Italy
    Int J Radiat Oncol Biol Phys 75:1570-7. 2009
    ....
  81. ncbi Manifestations and mechanisms of non-targeted effects of ionizing radiation
    Eric G Wright
    University of Dundee, Centre for Oncology and Molecular Medicine, Division of Medical Sciences, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, UK
    Mutat Res 687:28-33. 2010
    ....
  82. ncbi Volumetric modulated arc therapy for advanced pancreatic cancer
    Wietse Eppinga
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Strahlenther Onkol 186:382-7. 2010
    ..A planning study evaluated if volumetric modulated arc therapy (RapidArc [RA]) could be used as an alternative to IMRT in such cases...
  83. ncbi High-dose-rate prostate brachytherapy: an excellent accelerated-hypofractionated treatment for favorable prostate cancer
    Alvaro A Martinez
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Am J Clin Oncol 33:481-8. 2010
    ..The 5-year experience at William Beaumont Hospital (WBH) and the California Endocurietherapy Center (CET) with accelerated-hypofractionated high-dose-rate (HDR) monotherapy in favorable prostate cancer is presented...
  84. ncbi Methionine positron emission tomography for differentiation of recurrent brain tumor and radiation necrosis after stereotactic radiosurgery--in malignant glioma
    Naohiro Tsuyuguchi
    Department of Neurosurgery, Osaka City University Graduate School of Medicine, Japan
    Ann Nucl Med 18:291-6. 2004
    ..Following stereotactic radiosurgery (SRS), we examined how to differentiate radiation necrosis from recurrent malignant glioma using positron emission tomography (PET) with 11C-methionine (Met)...
  85. ncbi Correlations between magnetic resonance spectroscopy and image-guided histopathology, with special attention to radiation necrosis
    Jack P Rock
    Hermelin Brain Tumor Center, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Neurosurgery 51:912-9; discussion 919-20. 2002
    ..Multivoxel proton magnetic resonance spectroscopic imaging ((1)H MRSI) may be reliable in guiding the clinical management of untreated patients; however, its value in managing previously treated patients remains unclear...
  86. ncbi Impact of radiation therapy on acute toxicity in breast conservation therapy for early breast cancer
    M Back
    Department of Radiation Oncology, The Newcastle Mater Misericordiae Hospital, Waratah, New South Wales, Australia
    Clin Oncol (R Coll Radiol) 16:12-6. 2004
    ..To document the acute toxicity experienced by women receiving radiation therapy as part of breast-conservation therapy (BCT) for early breast cancer...
  87. ncbi Multivariable modeling of radiotherapy outcomes, including dose-volume and clinical factors
    Issam El Naqa
    Department of Radiation Oncology, Washington University, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 64:1275-86. 2006
    ..Current models are usually oversimplified. We describe alternative methods for building multivariable dose-response models...
  88. ncbi Post-irradiation approaches to treatment of radiation injuries in the context of radiological terrorism and radiation accidents: a review
    J E Moulder
    Radiation Oncology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Int J Radiat Biol 80:3-10. 2004
    ..This review discusses recent advances in the knowledge about how radiation injuries from such events might be treated pharmacologically, and the practical barriers to clinical utilization of ..
  89. ncbi Chest wall volume receiving >30 Gy predicts risk of severe pain and/or rib fracture after lung stereotactic body radiotherapy
    Neal E Dunlap
    University of Virginia, Charlottesville, VA 22908, USA
    Int J Radiat Oncol Biol Phys 76:796-801. 2010
    ..To identify the dose-volume parameters that predict the risk of chest wall (CW) pain and/or rib fracture after lung stereotactic body radiotherapy...
  90. ncbi Intensity modulated radiation therapy (IMRT) decreases acute skin toxicity for women receiving radiation for breast cancer
    Gary M Freedman
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Am J Clin Oncol 29:66-70. 2006
    ..Our hypothesis is that measures to decrease dose inhomogeneity within the breast and skin with IMRT will improve acute skin toxicity...
  91. ncbi Radiation dose-volume effects in the spinal cord
    John P Kirkpatrick
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 76:S42-9. 2010
    ..However, long-term data are insufficient to calculate a dose-volume relationship for myelopathy when the partial cord is treated with a hypofractionated regimen...
  92. ncbi Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Report of an NCI Workshop, December 3-4, 2003
    Helen B Stone
    National Cancer Institute, Bethesda, Maryland 20892, USA
    Radiat Res 162:711-28. 2004
    To develop approaches to prophylaxis/protection, mitigation and treatment of radiation injuries, appropriate models are needed that integrate the complex events that occur in the radiation-exposed organism...
  93. ncbi Some novel approaches for radioprotection and the beneficial effect of natural products
    Dharmendra K Maurya
    Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai, India
    Indian J Exp Biol 44:93-114. 2006
    ....
  94. ncbi Treatment of radiation proctitis with argon plasma coagulation
    W Tam
    Dept of Gastroenterology, Hepatology and General Medicine, Royal Adelaide Hospital, South Australia, Australia
    Endoscopy 32:667-72. 2000
    ..Therapeutic options for this condition are limited. This study was undertaken to evaluate the usefulness of argon plasma coagulation (APC) in the treatment of rectal bleeding due to radiation proctitis...
  95. pmc Differentiation of recurrent glioblastoma multiforme from radiation necrosis after external beam radiation therapy with dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging
    Ramon F Barajas
    Department of Radiology, Neuroradiology Section, University of California, San Francisco, CA 94143, USA
    Radiology 253:486-96. 2009
    ....
  96. ncbi Carcinoma of paranasal sinuses: long-term outcomes with radiotherapy
    Angel I Blanco
    Department of Radiation Oncology, Washington University, St Louis, MO, USA
    Int J Radiat Oncol Biol Phys 59:51-8. 2004
    ..To assess the clinical features, prognostic factors, results, and complications of treatment of carcinomas of the paranasal sinus...
  97. pmc The autophagy-inducing drug carbamazepine is a radiation protector and mitigator
    Hyun Kim
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA
    Int J Radiat Biol 87:1052-60. 2011
    ..To determine whether Carbamazepine (CBZ) is a radiation protector and/or mitigator...
  98. pmc Review and meta-analysis of epidemiological associations between low/moderate doses of ionizing radiation and circulatory disease risks, and their possible mechanisms
    M P Little
    Department of Epidemiology and Public Health, Imperial College Faculty of Medicine, Norfolk Place, London, W2 1PG, UK
    Radiat Environ Biophys 49:139-53. 2010
    ..Although the predictions of the model are consistent with the epidemiological data, the experimental predictions made have yet to be tested. Further epidemiological and biological evidence will allow a firmer conclusion to be drawn...
  99. ncbi Evidence-based organ-sparing radiotherapy in head and neck cancer
    Piet Dirix
    Department of Radiation Oncology, Leuven Cancer Institute LKI, Leuven, Belgium
    Lancet Oncol 11:85-91. 2010
    ..Because xerostomia and dysphagia are the main causes of decreased quality of life after radiotherapy for head and neck cancer, the prevention of these two complications will form the focus of this review...
  100. ncbi Emerging therapy for improving wound repair of severe radiation burns using local bone marrow-derived stem cell administrations
    Eric Bey
    hôpital d instruction des armées Percy, Service de Chirurgie Plastique, BP 410, 92141 Clamart Cedex, France
    Wound Repair Regen 18:50-8. 2010
    ..The success of this combined treatment leads to new prospects in the medical management of severe radiation burns and more widely in the improvement of wound repair...
  101. ncbi Ultraviolet radiation-induced injury, chemokines, and leukocyte recruitment: An amplification cycle triggering cutaneous lupus erythematosus
    Stephan Meller
    Heinrich Heine University, Dusseldorf, Germany
    Arthritis Rheum 52:1504-16. 2005
    ..To investigate the activation and recruitment pathways of relevant leukocyte subsets during the initiation and amplification of cutaneous lupus erythematosus (LE)...

Research Grants70

  1. Development of lisinopril for post-exposure mitigation of late effects from a rad
    MEETHA M MEDHORA; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Our research goal has been to mitigate radiation injuries to the lungs and kidneys. Mitigation is the use of a countermeasure after exposure to ionizing radiation but before symptoms develop...
  2. Post-Irradiation Intervention to Mitigate and Treat Non Hematological Radiation
    JOHN MOULDER; Fiscal Year: 2009
    ..the Center is to develop pharmacologic approaches for the mitigation and treatment of the non-hematological radiation injuries that will occur in victims of radiological terrorism or radiation accidents who receive doses in excess of 5 ..
  3. Mitigation of Radiation Pneumonitis and Fibrosis
    ERIC PHIN COHEN; Fiscal Year: 2013
    ..The broad, long-term objective of our work is to achieve effective and safe mitigation o normal tissue radiation injuries for any tissue type...
  4. Restoring Immune Function Following Radiation Injuries by TLR9 Agonist Treatment
    James A Lederer; Fiscal Year: 2013
    ..Collectively, the results of these studies will provide pre-clinical data for translating CpG ODNs as effective medical countermeasures for treating to the variety of injuries that could occur following a nuclear event. ..
  5. ANALYSIS OF RADIATION INJURIES IN 440 OVERDOSED PATIENTS
    Timothy Schultheiss; Fiscal Year: 1993
    ..taken account of censoring that results from the death of patients prior to and during the period that late radiation injuries are expressed...
  6. OCULAR MELANOMA
    Paul Finger; Fiscal Year: 2003
    ..Standardized clinical and data collection procedures will be employed, and standardized forms will be used in all centers. Central training and certification of all study staff will be required. ..
  7. Non-Invasive Localization of Vulnerable Plaques
    Cynthia McCollough; Fiscal Year: 2009
    ....
  8. KIDNEY RESPONSE TO RADIATION AND CHEMOTHERAPY
    JOHN MOULDER; Fiscal Year: 2006
    ..These latter findings cast considerable doubt on the standard mechanistic explanations for late radiation injuries, and suggest that injuries caused by radiation therapy, radiation accidents or nuclear terrorism could be ..
  9. Dose-Volume Modeling of Late Rectal and Bladder Toxicity
    Susan Tucker; Fiscal Year: 2007
    ..We expect the results of our analyses to play an important role in furthering the development of conformal techniques in RT of the prostate and other pelvic sites. ..
  10. HIGH ENERGY IONS AND GENOMIC INSTABILITY
    Eric Hall; Fiscal Year: 2001
    ....
  11. The Renin-Angiotensin System, Inflammation and Radiation-induced Brain Injury
    Michael E Robbins; Fiscal Year: 2010
    ....
  12. Hospice Pain Control: Developing an Opioid Order Sheet
    Barbara Murphy; Fiscal Year: 2006
    ..Once the modifications lave been made, we will conduct a pilot study to assess feasibility, utility and efficacy of the order sheet in the outpatient hospice setting. [unreadable] [unreadable]..
  13. Neural Predictors and RAS Modulation of Radiation-induced Cognitive Impairment
    Michael E Robbins; Fiscal Year: 2010
    ..These studies should provide information that is likely to lead to treatments that ameliorate radiation-induced brain injury, including cognitive impairment;thereby, addressing one of NCI's new areas of public health emphasis. ..
  14. PUFA-MEDIATED MODULATION OF RAT CATALASE EXPRESSION
    Michael Robbins; Fiscal Year: 2003
    ....
  15. NORMAL TISSUE DOSE VOLUME RESPONSE IN RADIATION THERAPY
    Timothy Schultheiss; Fiscal Year: 2002
    ..This form of data splitting will be used to determine if the model(s) fit the new data, thereby validating the initial results. ..
  16. RADIATION RESPONSE OF THE NORMAL SUBEPENDYMA
    JOHN FIKE; Fiscal Year: 2001
    ..abstract_text> ..
  17. PATHOGENESIS OF RADIATION-INDUCED KIDNEY INJURY
    Michael Robbins; Fiscal Year: 2004
    ..These studies offer the promise of developing rational therapeutic strategies directed at reducing the severity of this dose-limiting morbidity in human beings. ..
  18. The Brain Tumor Epidemiology Consortium Fall '05 Meeting
    Faith Davis; Fiscal Year: 2005
    ..This meeting will bring together neuro-pathologists and epidemiologists to address these issues as they pertain to BTEC projects. ..
  19. Occupational exposures and brain cancer
    Elisabeth Cardis; Fiscal Year: 2010
    ..Further analyses of possible interactions between EMF and specific chemicals will also be conducted. ..
  20. Role of EETs in Growth of Human Endothelial Cells
    Meetha Medhora; Fiscal Year: 2006
    ..It will impact on the potential for development of EETs as therapeutic agents during and after cardiac ischemia and acute lung injury. ..
  21. Eugene P. Cronkite Symposium
    Nicholas Dainiak; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  22. Comparative DNA Microarray Analysis of Brain Tumors
    Daniel Brat; Fiscal Year: 2006
    ....
  23. TIME RELATED FACTORS IN CANCER EPIDEMIOLOGY
    Bryan Langholz; Fiscal Year: 2006
    ..The impact of these projects is to expand the design and analysis "tools"' available to epidemiologic research in a way that will improve validity and cost-efficiency. [unreadable] [unreadable]..
  24. Non-invasive beta-cell imaging using a Ga-68-labeled glucagone-like peptide-1 ana
    Martin Gotthardt; Fiscal Year: 2008
    ..Apart from proof-of-principle studies in healthy volunteers and diabetes type I and II patients, a dosimetric method will be established to simply and reliably quantify beta-cell mass by PET imaging. [unreadable] [unreadable]..
  25. Adolescent daughters' response and adjustment to maternal breast cancer
    DANUTA CLEMMENS; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  26. US Prostate Cancer Detection with Dutasteride Pretreatment
    Ethan Halpern; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  27. Vaso-occlusive Mechanisms that Induce Hypoxia and Cause Glioma Progression.
    Daniel J Brat; Fiscal Year: 2010
    ..This proposal introduces entirely novel concepts that may explain the highly aggressive properties of GBM and suggests therapeutic approaches that could potentially stabilize its progression. ..
  28. CHRONIC HYPOXIA AND RESISTANCE TO MYOCARDIAL ISCHEMIA
    John E Baker; Fiscal Year: 2010
    ..The results of these studies are expected to have an impact on our understanding of the biology of Tpo in heart and may lead to the development of new therapeutics for the treatment of myocardial infarction. ..
  29. Molecular Characterization of p53R2 in Head and Neck Ca
    Stuart Wong; Fiscal Year: 2004
    ..We will identify and characterize the frequency of p53R2 gene SNPs in HNSCC patients and test the hypothesis that p53R2 gene SNPs predict adverse normal tissue radiation effects in HNSCC patients treated with radiation. ..
  30. Human Brain Protein MR Imaging and Spectroscopy at 3T
    Jinyuan Zhou; Fiscal Year: 2004
    ..The successful outcome of this application will offer a sensitive and specific modality in the clinical MRI examination of diseases. ..
  31. Pilot study on the safety and efficacy of ciprofloxacin for prophylactic preventi
    Hans Herfarth; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  32. P28-DRA IN THE STRESS RESPONSE OF MAMMALIAN CELLS
    Michael Story; Fiscal Year: 2001
    ..Understanding how p28dra functions will provide new insights into overcoming resistance to cancer therapy and possibly lead to new clinical strategies in cancer management. ..
  33. Mammography and High-Risk Survivors of Pediatric Cancer
    Kevin Oeffinger; Fiscal Year: 2005
    ....
  34. Outcomes Research and Training in Oncology
    James Talcott; Fiscal Year: 2005
    ..One approach to these issues is to identify differences in outcomes based on the mode of diagnosis (screening vs. investigation of symptoms). ..
  35. Mechanisms and Treatment of Cancer-Related Symptoms Conf
    Charles Cleeland; Fiscal Year: 2005
    ..The conference should also be of interest to pharmaceutical companies that are developing "pipeline" drugs for symptom control and supportive care. ..
  36. MR of post traumatic axonal de- and regeneration
    David Hackney; Fiscal Year: 2005
    ..abstract_text> ..
  37. NUCLEOPROTEINS IN MAMMALIAN SPERMATOGENESIS
    Marvin Meistrich; Fiscal Year: 2006
    ..Thus they provide a well-defined model system for study of human infertility. ..
  38. Cardiovascular Risk 50 Years After Thymic Irradiation
    Michael Adams; Fiscal Year: 2007
    ..This group of individuals, if shown to be at high risk, constitutes a potentially huge number of persons who may benefit from additional preventive measures. ..
  39. Endothelial Dysfunction in Intestinal Radiation Toxicity
    Martin Hauer Jensen; Fiscal Year: 2009
    ..This project may thus facilitate development of specific strategies to minimize intestinal radiation toxicity, thereby making radiation therapy safer and more effective. ..
  40. Radiation injury to the heart
    John E Baker; Fiscal Year: 2010
    ..1 ..
  41. RADIOTHERAPY EFFECTS ON BRAIN FUNCTIONING IN ADULTS
    CAROL ARMSTRONG; Fiscal Year: 2001
    ..They will gather pilot data on the sensitivity of MTI to radiation effects in 37 cases during the early and late delayed periods. Standard brain regions, tumor sites and specific regions will be examined. ..
  42. Imaging Thymidine Uptake During Treatment for Head and Neck Cancer
    Yusuf Menda; Fiscal Year: 2008
    ..The studies proposed here will refine and characterize a non-invasive imaging test that may allow treatment responses to be determined shortly after treatment has begun. [unreadable] [unreadable] [unreadable]..
  43. Assessment of BBB Disruption during RT using DCE MRI
    Yue Cao; Fiscal Year: 2006
    ..Data from these scans will be analyzed to quantify vascular permeability, which related to dose, volume, time, and presence in tumor versus normal brain tissue. ..
  44. Neurogenesis, Inflammation and Irradiation Injury
    MICHELLE MONJE DEISSEROTH; Fiscal Year: 2003
    ..abstract_text> ..
  45. Intravascular Thrombosis in Glioblastoma
    Daniel Brat; Fiscal Year: 2005
    ..Our emerging model represents a paradigm shift in the understanding of GBM and should lead directly to more effective therapies. ..
  46. Vacsular Remodeling and Effects of Angiogenic Inhibition in Diabetic Retinopathy
    Peter Kaiser; Fiscal Year: 2006
    ..The CAM continues to serve as a convenient testbed for ongoing development of fractal methods and for examination of effects of human regulators on angiogenesis and vascular remodeling. ..
  47. MOLECULAR PATHOGENESIS OF RADIATION ENTEROPATHY
    Martin Hauer Jensen; Fiscal Year: 2005
    ..This project may facilitate development of specific strategies to minimize intestinal radiation toxicity, thereby making radiation therapy safer and more effective. ..
  48. Understanding the Impact of Multiple Symptoms: A Symptom Burden Consortium
    Charles Cleeland; Fiscal Year: 2006
    ..The document will be a collaborative effort among consortium participants, and will be submitted to a leading scientific peer-reviewed journal. [unreadable] [unreadable] [unreadable] [unreadable]..
  49. Mechanisms of Radiation-Induced Genomic Istability
    William Morgan; Fiscal Year: 2005
    ....
  50. Genetic Reg. of Hematopoietic Stem Cell Mobilization
    Hartmut Geiger; Fiscal Year: 2007
    ..g. to muscle tissue, or to other hematopoietic niches. ..
  51. Imaging Biomarkers for Cancer Drug Development
    ALMA SORENSEN; Fiscal Year: 2004
    ..The planning grant revolves around three aims: to confer a multidisciplinary partnership to work towards this goal; to select a set of demonstration projects, and to develop an operating plan for the partnership. ..
  52. Role of ATM in Radiosensitivity of Gliomas
    Chandan Guha; Fiscal Year: 2004
    ..IV) To investigate the combined toxicity of the virus vectors, ATM attenuation and radiation therapy in cultured endothelial cells, astrocytes, oligodendrocytes, neurons and brain tissues in mice models. ..
  53. BYSTANDER EFFECTS AND X RAY INDUCED GENOMIC INSTABILITY
    William Morgan; Fiscal Year: 2004
    ..Identifying the BSEF would enhance our understanding of how radiation exerts its deleterious effects and could directly impact risk estimation for radiation exposure. ..
  54. CHILDRENS CANCER GROUP
    Katherine Matthay; Fiscal Year: 2002
    ..Our strong biology research laboratories in brain tumors, neuroblastoma and myeloproliferative disorders are conducting multiple biology studies in the Group and providing new information for future studies. ..
  55. Sharing canonical human stroke data
    Ona Wu; Fiscal Year: 2010
    ..Linking our existing portals with BIRN resources has the potential to greatly facilitate data sharing which will benefit the understanding of stroke and speed discovery of new therapeutic interventions. ..
  56. Imaging Archive for Magnetic Resonance Imaging Systems
    ALMA SORENSEN; Fiscal Year: 2005
    ..Overall, this needed resource will greatly facilitate many NIH-funded investigators and investigations for years to come. ..
  57. A 3.0 Tesla MRI System in a Neuroscience ICU
    ALMA SORENSEN; Fiscal Year: 2004
    ..Since these subjects are difficult to bring to the instrumentation, we seek to gain these insights by bringing the instrumentation to them. The proposed instrument will bring state-of-the-art performance to a unique setting. ..
  58. High Resolution PET Camera for Brain Imaging
    ALMA SORENSEN; Fiscal Year: 2006
    ..Placement of the HRRT in the proposed environment will provide a unique facility to advance brain imaging research that in turn will provide insights for a variety of illnesses and biomedical questions. [unreadable] [unreadable]..
  59. MRI DIFFUSION/PERFUSION MISMATCH IN HUMAN ACUTE STROKE
    ALMA SORENSEN; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  60. 131 I-MIBG Escalating Dose Rapid Sequence Double Infusi*
    Katherine Matthay; Fiscal Year: 2004
    ..Significance: The higher tumor-specific radiation doses possible with this protocol may provide a treatment to improve response and survival in children with resistant neuroblastoma. ..
  61. Silicon Graphics Prism Extreme 128P/1TB
    ALMA SORENSEN; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  62. 7T Translational MRI System
    ALMA SORENSEN; Fiscal Year: 2007
    ..We list 24 funded projects in support of this additional instrumentation. [unreadable] [unreadable] [unreadable]..
  63. Spatial-Temporal Imaging of Cell Proliferation & Hypoxia
    Robert Jeraj; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  64. PROJECT ALLIFE-EXERCISE AND LEUKEMIA SURVIVORS
    Kevin Oeffinger; Fiscal Year: 2006
    ..This study will represent the first clinical trial aimed at increasing physical activity in leukemia survivors and will advance our understanding of this vulnerable population. ..
  65. Presurgery Hypnosis in Breast Cancer: Benefits Analysis
    Guy Montgomery; Fiscal Year: 2006
    ..Mediators and moderators (e.g., hypnotizability) of hypnosis effects will be determined, as well as long-term side benefits of the intervention. ..
  66. Accurate Models for Predicting Radiation-Induced Injury
    Shiva Das; Fiscal Year: 2009
    ..They will be made publicly available via the Internet. The overall impact of this work will be to facilitate significant reduction in thoracic radiotherapy-induced injury via accurate prediction. ..
  67. Breast Cancer, Radiation and the ATM-CHEK2 Pathway
    Jonine Bernstein; Fiscal Year: 2008
    ..Conduct a population-based case-control association study of 6 genes involved in the ATM-CHEK2 pathway to determine whether they are associated with an increased risk of radiation-induced contralateral breast cancer. ..
  68. Presurgery Hypnosis--Benefits Analysis in Breast Cancer
    Guy Montgomery; Fiscal Year: 2003
    ..The possible mediational role of these factors in hypnosis effects will be examined will classic statistical approaches. ..
  69. ANTICANCER DRUG RESISTANCE BY BCL-2 ONCOGENE EXPRESSION
    Raymond Meyn; Fiscal Year: 2007
    ..abstract_text> ..