hip fractures

Summary

Summary: Fractures of the FEMUR HEAD; the FEMUR NECK; (FEMORAL NECK FRACTURES); the trochanters; or the inter- or subtrochanteric region. Excludes fractures of the acetabulum and fractures of the femoral shaft below the subtrochanteric region (FEMORAL FRACTURES).

Top Publications

  1. ncbi An estimate of the worldwide prevalence and disability associated with osteoporotic fractures
    O Johnell
    Department of Orthopaedics, Malmo University Hospital, Malmo, Sweden
    Osteoporos Int 17:1726-33. 2006
  2. pmc Secular trends in the incidence of hip and other osteoporotic fractures
    C Cooper
    The MRC Lifecourse Epidemiology Unit, Southampton General Hospital, University of Southampton, Southampton SO16 6YD, UK
    Osteoporos Int 22:1277-88. 2011
  3. ncbi The burden of osteoporotic fractures: a method for setting intervention thresholds
    J A Kanis
    WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, UK
    Osteoporos Int 12:417-27. 2001
  4. pmc Meta-analysis: excess mortality after hip fracture among older women and men
    Patrick Haentjens
    Centre for Outcomes Research and Laboratory for Experimental Surgery, Universitair Ziekenhuis Brussel, Jette, Vrije Universiteit Brussel, Elsene, Belgium
    Ann Intern Med 152:380-90. 2010
  5. pmc A systematic review of hip fracture incidence and probability of fracture worldwide
    J A Kanis
    WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Beech Hill Road, Sheffield, UK
    Osteoporos Int 23:2239-56. 2012
  6. ncbi Body mass index as a predictor of fracture risk: a meta-analysis
    C de Laet
    Scientific Institute of Public Health, Brussels, Belgium
    Osteoporos Int 16:1330-8. 2005
  7. ncbi Bisphosphonates and fractures of the subtrochanteric or diaphyseal femur
    Dennis M Black
    University of California at San Francisco, San Francisco, CA 94107, USA
    N Engl J Med 362:1761-71. 2010
  8. pmc Effect of early surgery after hip fracture on mortality and complications: systematic review and meta-analysis
    Nicole Simunovic
    Department of Clinical Epidemiology and Biostatistics, McMasterUniversity, Hamilton, Ontario, Canada
    CMAJ 182:1609-16. 2010
  9. pmc Predicting risk of osteoporotic fracture in men and women in England and Wales: prospective derivation and validation of QFractureScores
    Julia Hippisley-Cox
    Division of Primary Care, Tower Building, University Park, Nottingham NG2 7RD
    BMJ 339:b4229. 2009
  10. ncbi Excess mortality following hip fracture: a systematic epidemiological review
    B Abrahamsen
    Department of Internal Medicine and Endocrinology, Copenhagen University Hospital Gentofte, Niels Andersensvej 65, 2900, Hellerup, Denmark
    Osteoporos Int 20:1633-50. 2009

Detail Information

Publications385 found, 100 shown here

  1. ncbi An estimate of the worldwide prevalence and disability associated with osteoporotic fractures
    O Johnell
    Department of Orthopaedics, Malmo University Hospital, Malmo, Sweden
    Osteoporos Int 17:1726-33. 2006
    ..The aim of this study was to quantify the global burden of osteoporotic fracture worldwide...
  2. pmc Secular trends in the incidence of hip and other osteoporotic fractures
    C Cooper
    The MRC Lifecourse Epidemiology Unit, Southampton General Hospital, University of Southampton, Southampton SO16 6YD, UK
    Osteoporos Int 22:1277-88. 2011
    ..Understanding the reasons for the recent declines in rates of hip fracture may help understand ways to reduce rates of hip fracture worldwide...
  3. ncbi The burden of osteoporotic fractures: a method for setting intervention thresholds
    J A Kanis
    WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, UK
    Osteoporos Int 12:417-27. 2001
    ....
  4. pmc Meta-analysis: excess mortality after hip fracture among older women and men
    Patrick Haentjens
    Centre for Outcomes Research and Laboratory for Experimental Surgery, Universitair Ziekenhuis Brussel, Jette, Vrije Universiteit Brussel, Elsene, Belgium
    Ann Intern Med 152:380-90. 2010
    ..Although an increased risk for death after hip fracture is well established, whether this excess mortality persists over time is unclear...
  5. pmc A systematic review of hip fracture incidence and probability of fracture worldwide
    J A Kanis
    WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Beech Hill Road, Sheffield, UK
    Osteoporos Int 23:2239-56. 2012
    ..There was a greater than 10-fold variation in hip fracture risk and fracture probability between countries...
  6. ncbi Body mass index as a predictor of fracture risk: a meta-analysis
    C de Laet
    Scientific Institute of Public Health, Brussels, Belgium
    Osteoporos Int 16:1330-8. 2005
    ..The significance of BMI as a risk factor varies according to the level of BMI. Its validation on an international basis permits the use of this risk factor in case-finding strategies...
  7. ncbi Bisphosphonates and fractures of the subtrochanteric or diaphyseal femur
    Dennis M Black
    University of California at San Francisco, San Francisco, CA 94107, USA
    N Engl J Med 362:1761-71. 2010
    ..A population-based study did not support this association. Such a relationship has not been examined in randomized trials...
  8. pmc Effect of early surgery after hip fracture on mortality and complications: systematic review and meta-analysis
    Nicole Simunovic
    Department of Clinical Epidemiology and Biostatistics, McMasterUniversity, Hamilton, Ontario, Canada
    CMAJ 182:1609-16. 2010
    ..We conducted a systematic review and meta-analysis to determine the effect of early surgery on the risk of death and common postoperative complications among elderly patients with hip fracture...
  9. pmc Predicting risk of osteoporotic fracture in men and women in England and Wales: prospective derivation and validation of QFractureScores
    Julia Hippisley-Cox
    Division of Primary Care, Tower Building, University Park, Nottingham NG2 7RD
    BMJ 339:b4229. 2009
    ..To develop and validate two new fracture risk algorithms (QFractureScores) for estimating the individual risk of osteoporotic fracture or hip fracture over 10 years...
  10. ncbi Excess mortality following hip fracture: a systematic epidemiological review
    B Abrahamsen
    Department of Internal Medicine and Endocrinology, Copenhagen University Hospital Gentofte, Niels Andersensvej 65, 2900, Hellerup, Denmark
    Osteoporos Int 20:1633-50. 2009
    ....
  11. ncbi Atypical subtrochanteric and diaphyseal femoral fractures: report of a task force of the American Society for Bone and Mineral Research
    Elizabeth Shane
    Columbia University, College of Physicians and Surgeons, PH 8 West 864, 630 West 168th Street, New York, NY 10032, USA
    J Bone Miner Res 25:2267-94. 2010
    ....
  12. ncbi Low-dose vitamin D prevents muscular atrophy and reduces falls and hip fractures in women after stroke: a randomized controlled trial
    Yoshihiro Sato
    Department of Neurology, Futase Social Insurance Hospital, Iizuka, Japan
    Cerebrovasc Dis 20:187-92. 2005
    ..The present study was undertaken to address the reduced risk of falls and hip fractures in patients with long-standing stroke by vitamin D supplementation.
  13. pmc Effect of comorbidities and postoperative complications on mortality after hip fracture in elderly people: prospective observational cohort study
    J J W Roche
    Department of Trauma and Orthopaedics, University Hospital Nottingham, Nottingham, NG7 2UH
    BMJ 331:1374. 2005
    ....
  14. ncbi FRAX underestimates fracture risk in patients with diabetes
    Lora M Giangregorio
    University of Waterloo, Waterloo, Canada
    J Bone Miner Res 27:301-8. 2012
    ..Multivariable Cox proportional hazards models were used to determine if diabetes was associated with incident hip fractures or major osteoporotic fractures after controlling for FRAX risk factors...
  15. ncbi Risk of hip fracture according to the World Health Organization criteria for osteopenia and osteoporosis
    J A Kanis
    WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Sheffield, UK
    Bone 27:585-90. 2000
    ..The decrease in relative risk with age is, however, associated with an increase in absolute risk. Thus, for clinical use, the expression of absolute risks may be preferred to relative risks...
  16. ncbi Calcium intake and hip fracture risk in men and women: a meta-analysis of prospective cohort studies and randomized controlled trials
    Heike A Bischoff-Ferrari
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 86:1780-90. 2007
    ..The role of total calcium intake in the prevention of hip fracture risk has not been well established...
  17. ncbi Older women with diabetes have an increased risk of fracture: a prospective study
    A V Schwartz
    Department of Epidemiology, Division of Endocrinology, University of California San Francisco, San Francisco, California 94105, USA
    J Clin Endocrinol Metab 86:32-8. 2001
    ..This study indicates that diabetes is a risk factor for hip, proximal humerus, and foot fractures among older women, suggesting that fracture prevention efforts should be a consideration in the treatment of diabetes...
  18. pmc Association of BMD and FRAX score with risk of fracture in older adults with type 2 diabetes
    Ann V Schwartz
    Department of Epidemiology and Biostatistics, University of California San Francisco, 185 Berry St, Lobby 5, Ste 5700, San Francisco, CA 94107 1762, USA
    JAMA 305:2184-92. 2011
    ..It is not known if low BMD, central to fracture prediction in older adults, identifies fracture risk in patients with DM...
  19. ncbi Requirements for DXA for the management of osteoporosis in Europe
    J A Kanis
    WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Beech Hill Road, Sheffield, S10 2RX, UK
    Osteoporos Int 16:229-38. 2005
    ..In 2000, the number of osteoporotic fractures was estimated at 3.79 million, of which 0.89 million were hip fractures (179,000 hip fractures in men and 711,000 in women). The total direct costs were estimated at 31...
  20. ncbi Mortality following hip fracture: trends and geographical variations over the last 40 years
    S Haleem
    Royal Sussex County Hospital, United Kingdom
    Injury 39:1157-63. 2008
    b>Hip fractures are an ever increasing cause of morbidity and mortality. Treatment of this condition requires an all-encompassing approach from prevention to post-operative care...
  21. pmc Results of the proximal femoral nail anti-rotation (PFNA) in elderly Chinese patients
    Jin Song Pu
    Department of Orthopaedic Surgery, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, 610041, Sichuan Province, People s Republic of China
    Int Orthop 33:1441-4. 2009
    ..However, the proximal end of the nail was not matched with the specific anatomy of some short elderly patients. Further modifications of the nail are necessary for the elderly Chinese population...
  22. ncbi Preoperative predictors for mortality following hip fracture surgery: a systematic review and meta-analysis
    Fangke Hu
    Medical College, Nankai University, 94 Weijin Road, Tianjin 300071, China
    Injury 43:676-85. 2012
    b>Hip fractures are always associated with a high postoperative mortality, the preoperative predictors for mortality have neither been well identified or summarised...
  23. ncbi Guidance for the adjustment of FRAX according to the dose of glucocorticoids
    J A Kanis
    WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Beech Hill Road, Sheffield S102RX, UK
    Osteoporos Int 22:809-16. 2011
    ..A relatively simple adjustment of conventional FRAX estimates of probabilities of hip fracture and a major osteoporotic fracture can be applied to modulate the risk assessment with knowledge of the dose of glucocorticoids...
  24. pmc Risk factors in cutout of sliding hip screw in intertrochanteric fractures: an evaluation of 937 patients
    Kuang Kai Hsueh
    Departments of Orthopaedics and Traumatology, Taipei Veterans General Hospital, National Yang Ming University, Taiwan, Republic of China corrected
    Int Orthop 34:1273-6. 2010
    ..In order to decrease the risk of lag-screw cutout, it is important to ensure good fracture reduction and to place the lag screw in either the middle/middle or inferior/middle position with appropriate TAD...
  25. ncbi Incidence and mortality of hip fractures in the United States
    Carmen A Brauer
    Division of Orthopedic Surgery, University of Calgary, Alberta Children s Hospital, 2888 Shaganappi Trail NW, Calgary, AB, Canada T3B 6A8
    JAMA 302:1573-9. 2009
    ..Understanding the incidence and subsequent mortality following hip fracture is essential to measuring population health and the value of improvements in health care...
  26. pmc The aftermath of hip fracture: discharge placement, functional status change, and mortality
    Suzanne E Bentler
    Department of Health Management and Policy, College of Public Health, University of Iowa, Iowa City, USA
    Am J Epidemiol 170:1290-9. 2009
    ..There were 495 postbaseline hip fractures among 5,511 respondents aged >or=69 years...
  27. ncbi Zoledronic acid and clinical fractures and mortality after hip fracture
    Kenneth W Lyles
    Duke University Medical Center, Durham, NC, USA
    N Engl J Med 357:1799-809. 2007
    ..Mortality is increased after a hip fracture, and strategies that improve outcomes are needed...
  28. ncbi The components of excess mortality after hip fracture
    J A Kanis
    WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, UK
    Bone 32:468-73. 2003
    ..We studied 160,000 hip fractures in men and women aged 50 years or more, in 28...
  29. ncbi Cardiovascular diseases and risk of hip fracture
    Ulf Sennerby
    Department of Surgical Sciences, Section of Orthopaedics, Uppsala University, SE 751 85 Uppsala, Sweden
    JAMA 302:1666-73. 2009
    ..Recent studies indicate common etiologies for cardiovascular disease (CVD) and osteoporotic fractures...
  30. ncbi Type 1 and type 2 diabetes and incident hip fractures in postmenopausal women
    K K Nicodemus
    University of Minnesota, Minneapolis, Minnesota, USA
    Diabetes Care 24:1192-7. 2001
    ..RESULTS: A total of 490 hip fractures were reported over 306,900 person-years of follow-up...
  31. pmc Inpatient rehabilitation specifically designed for geriatric patients: systematic review and meta-analysis of randomised controlled trials
    Stefan Bachmann
    Department of Geriatrics, Inselspital, University of Bern Hospital, Freiburgstrasse 10, CH 3010 Bern, Switzerland
    BMJ 340:c1718. 2010
    ..To assess the effects of inpatient rehabilitation specifically designed for geriatric patients compared with usual care on functional status, admissions to nursing homes, and mortality...
  32. ncbi Trochanteric gamma nail and compression hip screw for trochanteric fractures: a randomized, prospective, comparative study in 210 elderly patients with a new design of the gamma nail
    A Lizaur Utrilla
    Department of Orthopaedic Surgery, Hospital General Elda, Elda, Alicante, Spain
    J Orthop Trauma 19:229-33. 2005
    ..To compare the results between a new intramedullary Gamma nail and a compression hip screw in the treatment of trochanteric fractures...
  33. ncbi Randomized comparison of reduction and fixation, bipolar hemiarthroplasty, and total hip arthroplasty. Treatment of displaced intracapsular hip fractures in healthy older patients
    J F Keating
    Department of Orthopaedic Trauma, Royal Infirmary, Little France, Old Dalkeith Road, Edinburgh EH16 4SU, Scotland
    J Bone Joint Surg Am 88:249-60. 2006
    ..The aim of this investigation was to determine the functional, clinical, and resource consequences of three different types of surgical treatment...
  34. ncbi Minimally invasive treatment of intertrochanteric hip fractures with the Gotfried percutaneous compression plate
    Edward Yang
    Leni and Peter May Department of Orthopedics, Mount Sinai School of Medicine, 5 E 98th St, Box 1188, New York, NY 10029, USA
    Orthopedics 31:29-36. 2008
  35. ncbi Pertrochanteric fractures: is there an advantage to an intramedullary nail?: a randomized, prospective study of 206 patients comparing the dynamic hip screw and proximal femoral nail
    Marc Saudan
    Clinique d orthopédie et de chirurgie de l appareil moteur, Hopital Cantonal Universitaire, Geneva, Switzerland
    J Orthop Trauma 16:386-93. 2002
    ..To compare the results between a sliding compression hip screw and an intramedullary nail in the treatment of pertrochanteric fractures...
  36. ncbi Effect of risedronate on the risk of hip fracture in elderly women. Hip Intervention Program Study Group
    M R McClung
    Oregon Osteoporosis Center and Providence Medical Center, Portland 97213, USA
    N Engl J Med 344:333-40. 2001
    ..Risedronate increases bone mineral density in elderly women, but whether it prevents hip fracture is not known...
  37. ncbi Efficacy of a comprehensive geriatric intervention in older patients hospitalized for hip fracture: a randomized, controlled trial
    Maite Vidán
    Department of Geriatric Medicine, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    J Am Geriatr Soc 53:1476-82. 2005
    ..To evaluate whether an early multidisciplinary geriatric intervention in elderly patients with hip fracture reduced length of stay, morbidity, and mortality and improved functional evolution...
  38. pmc Mortality and cause of death in hip fracture patients aged 65 or older: a population-based study
    Jorma Panula
    Department of Surgery, City Hospital of Pori, Pori, Finland
    BMC Musculoskelet Disord 12:105. 2011
    ..The purpose of the present study was to evaluate mortality and cause of death in patients after hip fracture surgery and to compare their mortality and cause of death to those in the general population...
  39. ncbi Cemented versus uncemented hemiarthroplasty for hip fractures: a systematic review of randomised controlled trials
    Shin Azegami
    Department of Orthopaedic Surgery, Peterborough District Hospital, Peterborough, UK
    Hip Int 21:509-17. 2011
    ..to compare the outcome between cemented and uncemented hemiarthroplasty for treatment of intracapsular hip fractures. We searched the Cochrane Bone, Joint and Muscle Trauma Group Specialised Register, the Cochrane Central ..
  40. pmc Proton pump inhibitors and histamine-2 receptor antagonists are associated with hip fractures among at-risk patients
    Douglas A Corley
    Kaiser Permanente Division of Research, Oakland, California 94612, USA
    Gastroenterology 139:93-101. 2010
    ..Drugs that inhibit gastric acid might increase the risk of hip fracture. However, little long-term exposure data exist and no large studies have been conducted in the United States...
  41. ncbi Evolving concepts of stability and intramedullary fixation of intertrochanteric fractures--a review
    Constantine Kokoroghiannis
    5th Orthopaedic Department, KAT Hospital, Nikis 2 Street, Kifissia, Athens 145 61, Greece
    Injury 43:686-93. 2012
    ..The importance of the size of the proximal fracture fragment has not yet been elucidated. Nail fixation is, thus, mandatory in a small percentage of grossly unstable fractures, whose characteristics are still undergoing definition...
  42. pmc Prospective randomised study comparing screw versus helical blade in the treatment of low-energy trochanteric fractures
    Richard Stern
    Division of Orthopaedics and Trauma Surgery, University Hospitals of Geneva, Geneva, Switzerland
    Int Orthop 35:1855-61. 2011
    ....
  43. pmc Early ambulation after hip fracture: effects on function and mortality
    Albert L Siu
    Mount Sinai School of Medicine, New York, NY, USA
    Arch Intern Med 166:766-71. 2006
    ..Few studies have examined the relationship between inpatient bed rest and functional outcomes. We examined how immobility is associated with function and mortality in patients with hip fracture...
  44. pmc Use of proton pump inhibitors and risk of hip/femur fracture: a population-based case-control study
    S Pouwels
    Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Universiteit Utrecht, P O BOX 80082, 3508 TB, Utrecht, The Netherlands
    Osteoporos Int 22:903-10. 2011
    ..Therefore, the objective was to evaluate this association in a different study population. Our findings show that there is probably no causal relationship between PPI use and hip fracture risk...
  45. ncbi Pitfalls in the external validation of FRAX
    J A Kanis
    WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, UK
    Osteoporos Int 23:423-31. 2012
    ..Recent studies have evaluated the performance of FRAX® in independent cohorts. The interpretation of most is problematic for reasons summarised in this perspective...
  46. ncbi Predictors of mortality after hip fracture: results from 1-year follow-up
    Giulio Pioli
    Orthogeriatric Unit, Department of Geriatrics and Muscoloskeletal Sciences, E O Galliera Hospital, Corso Mentana 10, 16128, Genova, Italy
    Aging Clin Exp Res 18:381-7. 2006
    ....
  47. ncbi Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis
    Dennis M Black
    University of California, San Francisco, San Francisco, CA 94107, USA
    N Engl J Med 356:1809-22. 2007
    ..We assessed the effects of annual infusions of zoledronic acid on fracture risk during a 3-year period...
  48. ncbi Impact of a comanaged Geriatric Fracture Center on short-term hip fracture outcomes
    Susan M Friedman
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14620, USA
    Arch Intern Med 169:1712-7. 2009
    b>Hip fractures are associated with substantial morbidity and mortality for older adults. Patients sustaining hip fractures usually have comorbid conditions that may benefit from comanagement by geriatricians and orthopedic surgeons.
  49. ncbi Predictors of mortality after hip fracture: a 10-year prospective study
    Nader Paksima
    Department of Orthopaedic Surgery, Division of Hand and Wrist Surgery, New York University School of Medicine, NY, USA
    Bull NYU Hosp Jt Dis 66:111-7. 2008
    ..A total of 1109 patients with hip fractures were included in a prospective database...
  50. ncbi Use of inhaled and oral glucocorticoids, severity of inflammatory disease and risk of hip/femur fracture: a population-based case-control study
    F De Vries
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, The Netherlands
    J Intern Med 261:170-7. 2007
    ..Patients using higher dosages of inhaled or oral glucocorticoids (GCs) have an increased risk of hip/femur fractures. The role of the underlying disease in the aetiology of this increased risk has not been widely studied...
  51. ncbi Proximal femur geometry to detect and distinguish femoral neck fractures from trochanteric fractures in postmenopausal women
    S Gnudi
    Dipartimento di Medicina Intema, Istituti Ortopedici Rizzoli, Bologna, Italy
    Osteoporos Int 13:69-73. 2002
    ..These results confirm the association of BMD with proximal femur fracture and support the evidence that PFG plays a significant role only in neck fracture prediction, since NSA is the best predictive parameter among those tested...
  52. ncbi The risk of hip fractures in older individuals with diabetes: a population-based study
    Lorraine L Lipscombe
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Diabetes Care 30:835-41. 2007
    ..However, they may still be at increased risk for hip fractures. Using population-based Ontario health care data, we compared the risk of hip fractures among men and women ..
  53. ncbi Risk of hip/femur fracture after stroke: a population-based case-control study
    Sander Pouwels
    Utrecht Institute for Pharmaceutical Sciences, Division of Pharmacoepidemiology and Pharmacotherapy, University Utrecht, Utrecht, The Netherlands
    Stroke 40:3281-5. 2009
    ..Therefore, our purpose is to evaluate this risk and investigate the time course of any elevated risk...
  54. ncbi Randomized controlled trial to investigate influence of the fluid challenge on duration of hospital stay and perioperative morbidity in patients with hip fractures
    R Venn
    Department of Anaesthesia and Intensive Care, Worthing Hospital, W Sussex UK
    Br J Anaesth 88:65-71. 2002
    ....
  55. pmc The hip fracture incidence curve is shifting to the right
    Ulrica Bergström
    Division of Surgery and Perioperative Science, Department of Orthopaedics, Sweden
    Acta Orthop 80:520-4. 2009
    The number of hip fractures has doubled in the last 30-40 years in many countries. Age-adjusted incidence has been reported to be decreasing in Europe and North America, but is there a decreasing trend in all age groups?
  56. pmc Use of anti-depressants and the risk of fracture of the hip or femur
    M W M van den Brand
    Department of Geriatric Medicine, University Medical Centre Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    Osteoporos Int 20:1705-13. 2009
    ..This should be considered when prescribing anti-depressants to patients...
  57. pmc Antipsychotic use and the risk of hip/femur fracture: a population-based case-control study
    S Pouwels
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Osteoporos Int 20:1499-506. 2009
    ..Furthermore, no evidence for a dose effect was found...
  58. ncbi Cancellous bone mechanical properties from normals and patients with hip fractures differ on the structure level, not on the bone hard tissue level
    J Homminga
    Orthopedic Research Laboratory, University of Nijmegen, Nijmegen, The Netherlands
    Bone 30:759-64. 2002
    ..We conclude that individuals with a history of osteoporotic fractures do not have weaker bone tissue. Architectural and mechanical anisotropy alone renders their bone weaker in the nonprimary loading direction...
  59. ncbi The impact of incident fractures on health-related quality of life: 5 years of data from the Canadian Multicentre Osteoporosis Study
    A Papaioannou
    McMaster University, Hamilton Health Sciences Chedoke Site, Hamilton, ON, Canada
    Osteoporos Int 20:703-14. 2009
    ..Incident fractures had a negative impact on HUI scores over time...
  60. ncbi An estimate of the worldwide prevalence, mortality and disability associated with hip fracture
    O Johnell
    Department of Orthopaedics, Malmo General Hospital, Malmo, Sweden
    Osteoporos Int 15:897-902. 2004
    ..In 1990 there were an estimated 1.31 million new hip fractures, and the prevalence of hip fractures with disability was 4.48 million...
  61. ncbi Long-term proton pump inhibitor therapy and risk of hip fracture
    Yu Xiao Yang
    Division of Gastroenterology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    JAMA 296:2947-53. 2006
    ..Proton pump inhibitors (PPIs) may interfere with calcium absorption through induction of hypochlorhydria but they also may reduce bone resorption through inhibition of osteoclastic vacuolar proton pumps...
  62. ncbi International variations in hip fracture probabilities: implications for risk assessment
    John A Kanis
    WHO Collaborating Center for Metabolic Bone Diseases, University of Sheffield Medical School, United Kingdom
    J Bone Miner Res 17:1237-44. 2002
    ..The categorization of hip fracture probabilities can be used to adjust intervention thresholds based on age, sex, and relative risk from a reference population such as Sweden...
  63. ncbi Outcomes ascertainment and adjudication methods in the Women's Health Initiative
    J David Curb
    Department of Geriatric Medicine, University of Hawaii, Honolulu, HI 96813, USA
    Ann Epidemiol 13:S122-8. 2003
  64. ncbi Haloperidol prophylaxis for elderly hip-surgery patients at risk for delirium: a randomized placebo-controlled study
    Kees J Kalisvaart
    Department of Geriatric Medicine, Medical Center Alkmaar, Alkmaar, The Netherlands
    J Am Geriatr Soc 53:1658-66. 2005
    ..To study the effectiveness of haloperidol prophylaxis on incidence, severity, and duration of postoperative delirium in elderly hip-surgery patients at risk for delirium...
  65. ncbi Epidemiology and outcomes of osteoporotic fractures
    Steven R Cummings
    Coordinating Center, Department of Medicine, University of California, San Francisco, CA 94105, USA
    Lancet 359:1761-7. 2002
    ..b>Hip fractures, the most serious outcome of osteoporosis, are becoming more frequent than before because the world's ..
  66. ncbi Trends in hip fracture rates in Canada
    William D Leslie
    Department of Medicine, University of Manitoba, Winnipeg, Canada
    JAMA 302:883-9. 2009
    b>Hip fractures are a public health concern because they are associated with significant morbidity, excess mortality, and the majority of the costs directly attributable to osteoporosis.
  67. ncbi Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes--a meta-analysis
    P Vestergaard
    The Osteoporosis Clinic, Aarhus Amtssygehus, Aarhus University Hospital, Tage Hansens Gade 2, 8000, Aarhus C, Denmark
    Osteoporos Int 18:427-44. 2007
    ..Diabetes affects bone metabolism. The hypothesis was that type 1 (T1D) and type 2 (T2D) affects BMD and fracture risk differently...
  68. ncbi Economic implications of hip fracture: health service use, institutional care and cost in Canada
    M E Wiktorowicz
    Departments of Epidemiology and Biostatistics and Political Science, University of Western Ontario, London, Ontario, Canada
    Osteoporos Int 12:271-8. 2001
    ..Annual economic implications of hip fracture in Canada are $650 million and are expected to rise to $2.4 billion by 2041...
  69. ncbi Calcium plus vitamin D supplementation and the risk of fractures
    Rebecca D Jackson
    Division of Endocrinology, Ohio State University, 485 McCampbell, 1581 Dodd Dr, Columbus, OH 43210, USA
    N Engl J Med 354:669-83. 2006
    ..The efficacy of calcium with vitamin D supplementation for preventing hip and other fractures in healthy postmenopausal women remains equivocal...
  70. ncbi Reducing delirium after hip fracture: a randomized trial
    E R Marcantonio
    Division of General Medicine and the Department of Orthopedic Surgery, Brigham and Women's Hospital, Boston, Massachusetts, USA
    J Am Geriatr Soc 49:516-22. 2001
    ..Our trial provides strong preliminary evidence that proactive geriatrics consultation may play an important role in the acute hospital management of hip-fracture patients...
  71. pmc FRAX and the assessment of fracture probability in men and women from the UK
    J A Kanis
    WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, UK
    Osteoporos Int 19:385-97. 2008
    ..A fracture risk assessment tool (FRAX) is developed based on the use of clinical risk factors with or without bone mineral density tests applied to the UK...
  72. pmc Best practices for elderly hip fracture patients. A systematic overview of the evidence
    Lauren A Beaupre
    Department of Surgery, Division of Orthopaedics, Capital Health, Edmonton, AB, Canada
    J Gen Intern Med 20:1019-25. 2005
    ..To determine evidence-based best practices for elderly hip fracture patients from the time of hospital admission to 6 months postfracture...
  73. ncbi Nail or plate fixation of intertrochanteric hip fractures: changing pattern of practice. A review of the American Board of Orthopaedic Surgery Database
    Jeffrey O Anglen
    Department of Orthopaedic Surgery, Indiana University, 541 Clinical Drive, Suite 600, Indianapolis, IN 46202, USA
    J Bone Joint Surg Am 90:700-7. 2008
    A new method of fixation for intertrochanteric hip fractures that involves the use of an intramedullary nail that interlocks proximally into the femoral head was introduced in the early 1990s...
  74. ncbi Increased incidence of hip fractures in dialysis patients with low serum parathyroid hormone
    M Coco
    Montefiore Medical Center, Bronx, NY 10467, USA
    Am J Kidney Dis 36:1115-21. 2000
    ..complications of renal osteodystrophy in patients with end-stage renal disease, we reviewed the incidence of hip fractures in our outpatient dialysis population from 1988 to 1998...
  75. ncbi Increased mortality in patients with a hip fracture-effect of pre-morbid conditions and post-fracture complications
    P Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Aarhus, Denmark
    Osteoporos Int 18:1583-93. 2007
    ..The main reason for the excess mortality was linked to the trauma that caused the hip fracture...
  76. ncbi Mortality risk after hip fracture
    Jeffrey Richmond
    Geriatric Hip Fracture Research Group, Department of Orthopaedic Surgery, Hospital for Joint Diseases, 301 East 17th Street, New York, NY 10003, USA
    J Orthop Trauma 17:53-6. 2003
    ..To determine the mortality risk following hip fracture and identify factors predictive of increased mortality...
  77. ncbi Excess mortality in men compared with women following a hip fracture. National analysis of comedications, comorbidity and survival
    Pia Nimann Kannegaard
    Kløverprisvej 109, 2650 Hvidovre, Denmark
    Age Ageing 39:203-9. 2010
    ..The aim of this study was to assess excess mortality following hip fracture and, if possible, identify reasons for the difference between mortality for the two genders...
  78. ncbi Prospective randomized controlled trial of an intramedullary nail versus dynamic screw and plate for intertrochanteric fractures of the femur
    C I Adams
    The Orthopaedic Trauma Unit, The Royal Infirmary of Edinburgh, Scotland
    J Orthop Trauma 15:394-400. 2001
    ..Routine use of the Gamma nail in this type of fracture cannot be recommended over the current standard treatment of dynamic hip screw and plate...
  79. ncbi Walking and leisure-time activity and risk of hip fracture in postmenopausal women
    Diane Feskanich
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
    JAMA 288:2300-6. 2002
    Physical activity can reduce the risk of hip fractures in older women, although the required type and duration of activity have not been determined...
  80. pmc Hip fracture
    Martyn Parker
    Orthopaedic Department, Peterborough and Stamford NHS Foundation Trust, Peterborough PE3 6DA
    BMJ 333:27-30. 2006
  81. pmc Development and application of a Japanese model of the WHO fracture risk assessment tool (FRAX)
    S Fujiwara
    Department of Clinical Studies, Radiation Effects Research Foundation, Hiroshima, Japan
    Osteoporos Int 19:429-35. 2008
    ....
  82. ncbi Mortality, disability, and nursing home use for persons with and without hip fracture: a population-based study
    Cynthia L Leibson
    Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Am Geriatr Soc 50:1644-50. 2002
    ..To compare persons with and without hip fracture for subsequent mortality and change in disability and nursing home (NH) use...
  83. pmc Association of hip strength estimates by finite-element analysis with fractures in women and men
    Shreyasee Amin
    Division of Rheumatology, Department of Internal Medicine, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Bone Miner Res 26:1593-600. 2011
    ..Furthermore, an estimated hip strength below 3000 N may represent a critical level of systemic skeletal fragility in both sexes that warrants further investigation...
  84. ncbi Plasma concentrations of pro- and anti-inflammatory cytokines and outcome prediction in elderly hip fracture patients
    Tiansheng Sun
    Department of Orthopedic Surgery, Beijing Army General Hospital, Dongcheng District, Nanmencang No 5, Beijing, China
    Injury 42:707-13. 2011
    b>Hip fractures, particularly intertrochanteric fractures, frequently occur in the elderly, and they are associated with a high incidence of complications and mortality...
  85. ncbi The proximal femoral nail antirotation (PFNA) in the treatment of proximal femoral fractures
    Dalibor Kristek
    Surgical Clinic, Osijek University Hospital Center, Osijek, Croatia
    Coll Antropol 34:937-40. 2010
    ..It is easily inserted with few intra- and postoperative complications and allows early weight bearing on the affected limb as well as quicker rehabilitation of patients...
  86. ncbi Predictors of mortality in older hip fracture inpatients admitted to an orthogeriatric unit in oslo, norway
    Kristin Holvik
    Department of Surgery, Diakonhjemmet Hospital, Oslo, Norway
    J Aging Health 22:1114-31. 2010
    ....
  87. ncbi A meta-analysis of percutaneous compression plate versus sliding hip screw for the management of intertrochanteric fractures of the hip
    Tao Cheng
    Department of Orthopaedic Surgery, Shanghai Sixth People s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People s Republic of China
    J Trauma Acute Care Surg 72:1435-43. 2012
    Intertrochanteric hip fractures are associated with high morbidity and mortality rates...
  88. ncbi Cost-effectiveness analysis of goal-directed hemodynamic treatment of elderly hip fracture patients: before clinical research starts
    Erzsebet Bartha
    Karolinska Institute, CLINTEC, Division of Anesthesiology, Karolinska University Hospital, Stockholm, Sweden
    Anesthesiology 117:519-30. 2012
    ..This study analyzed cost-effectiveness using a decision analytic model before initiating a large clinical research project on goal-directed hemodynamic treatment of elderly patients with hip fracture...
  89. pmc Hip fracture and increased short-term but not long-term mortality in healthy older women
    Erin S LeBlanc
    Center for Health Research, Kaiser Permanente Northwest, 3800 N Interstate Ave, Portland, OR 97227, USA
    Arch Intern Med 171:1831-7. 2011
    ..Fractures have been associated with subsequent increases in mortality, but it is unknown how long that increase persists...
  90. ncbi Rapidly increasing rates of hip fracture in Beijing, China
    Wei bo Xia
    Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, People s Republic of China
    J Bone Miner Res 27:125-9. 2012
    The age-specific rates of hip fractures have been declining in most countries in the West but a few studies suggest that the rates might be increasing in areas of Asia that are undergoing urbanization...
  91. ncbi Is magnetic resonance imaging (MRI) necessary to exclude occult hip fracture?
    M Hossain
    Department of Orthopaedics and Trauma, Ysbyty Gwynedd, Bangor, UK
    Injury 38:1204-8. 2007
    ..We reviewed all patients who had MRI scan for suspected hip fractures but had normal initial X-rays over a 6-year period. We identified 76 patients. Twelve patients were excluded...
  92. ncbi A laboratory model to evaluate cutout resistance of implants for pertrochanteric fracture fixation
    Mark B Sommers
    Biomechanics Laboratory, Legacy Clinical Research and Technology Center, Portland, OR 97232, USA
    J Orthop Trauma 18:361-8. 2004
    ..To establish a laboratory model of implant cutout, which can evaluate the effect of implant design on cutout resistance in a clinically realistic "worst case" scenario...
  93. ncbi A randomised, controlled comparison of different calcium and vitamin D supplementation regimens in elderly women after hip fracture: The Nottingham Neck of Femur (NONOF) Study
    Rowan H Harwood
    Health Care of the Elderly, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Age Ageing 33:45-51. 2004
    ..survivors of hip fracture are at 5- to 10-fold risk of a second hip fracture. There is little consensus about secondary prevention. Many are given calcium and vitamin D, but the evidence supporting this is circumstantial...
  94. ncbi Hip fractures among the elderly: causes, consequences and control
    Ray Marks
    Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA
    Ageing Res Rev 2:57-93. 2003
    ..These data reveal hip fractures have several causes, but among these, the impact of falls and muscle weakness, along with low physical ..
  95. ncbi Falls, osteoporosis, and hip fractures
    Lenise A Cummings-Vaughn
    Jefferson Barracks Division, Department of Internal Medicine, Geriatric Research, Education, and Clinical Center, Saint Louis Veterans Affairs Medical Center, 1 Jefferson Barracks Drive, St Louis, MO 63125, USA
    Med Clin North Am 95:495-506, x. 2011
    ..By understanding the evidence, it becomes clearer how to target populations at risk, interpret screening methods, and promote disease prevention and treatment...
  96. ncbi Impact of surgical complications on length of stay after hip fracture surgery
    Nicolai B Foss
    Department of Orthopaedic Surgery, Hvidovre University Hospital, Denmark
    Injury 38:780-4. 2007
    ..Data suggest that surgical complications requiring reoperation may lead to an excessively long in-patient stays. However, the overall impact of surgical complications has not been examined in detail...
  97. ncbi Milk intake during childhood and adolescence, adult bone density, and osteoporotic fractures in US women
    Heidi J Kalkwarf
    Division of General and Community Pediatrics, Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Am J Clin Nutr 77:257-65. 2003
    ..Calcium supplements increase bone mass in children, but the effect does not persist once supplementation is discontinued...
  98. ncbi Development and initial validation of a risk score for predicting in-hospital and 1-year mortality in patients with hip fractures
    Hong X Jiang
    Royal Alexandra Hospital, Edmonton, Alberta, Canada
    J Bone Miner Res 20:494-500. 2005
    ..Our methods, after further validation, may be useful for comparing outcomes across hospitals or regions...
  99. ncbi FRAX assessment of osteoporotic fracture probability in Switzerland
    K Lippuner
    Osteoporosis Policlinic, Inselspital, Bern University Hospital and University of Bern, 3010, Bern, Switzerland
    Osteoporos Int 21:381-9. 2010
    ..Patient profiles at increased probability of fracture beyond currently accepted reimbursement thresholds for bone mineral density (BMD) measurement by dual X-ray absorptiometry (DXA), and osteoporosis treatment were identified...
  100. ncbi Delirium in elderly individuals with hip fracture: causes, incidence, prevalence, and risk factors
    Maria Elizabet Furlaneto
    Geriatric Orthopedic Group, Institute of Orthopedics and Traumatology, Hospital das Clinicas, São Paulo University Medical School São Paulo SP, Brazil
    Clinics (Sao Paulo) 61:35-40. 2006
    To determine the incidence, prevalence, risk factors, and causes of delirium in elderly individuals with hip fractures, as well as the impact of delirium on mortality and length of hospital stay.
  101. ncbi Predictive value of six risk scores for outcome after surgical repair of hip fracture in elderly patients
    E Burgos
    Anaesthesia Unit, Anaesthesia and Critical Care Department, Fundacion Hospital Alcorcon, Madrid, Spain
    Acta Anaesthesiol Scand 52:125-31. 2008
    ..The purpose of this study was to assess the predictive value of six functional status and/or surgical risk scoring systems with regard to serious complications after hip fracture surgery in the elderly...

Research Grants64

  1. Hip Fracture Evaluation Alternatives of Total Hip vs Hemi-arthroplasty (HEALTH)
    Thomas Einhorn; Fiscal Year: 2009
    Scope of the Problem: Hip fractures occur in 280,000 Americans, over 5,000 per week...
  2. Immune Regulation of Bone Homeostasis
    MERVYN NEALE WEITZMANN; Fiscal Year: 2012
    ..Fractures lead to huge healthcare expenditures, loss of mobility, and morbidity. Hip fractures almost always require surgery and mortality rates are extremely high in aged individuals following surgery...
  3. Salivary-based Bone-loss Marker Detection Platform for Point-of-Care Screening
    MANAL BESHAY; Fiscal Year: 2012
    ..in older women, it is usually only diagnosed at a later stage when morbid symptoms, such as spine or hip fractures, have occurred...
  4. Osteoclastic Protein-Tyrosine Phosphatase and Resorption
    Kin Hing William Lau; Fiscal Year: 2013
    ..A reduction in hip fractures, which can be a particular debilitating symptom of osteoporosis, would be desirable with respect to reduction ..
  5. Novel Drug VS-105 for Treatment of Osteoporosis
    Jinshyun Ruth Wu-Wong; Fiscal Year: 2013
    ..National Osteoporosis Foundation estimated that the US national direct expenditures for osteoporotic hip fractures were at $17 billion in 2005 and it would increase to $25 billion in 2025...
  6. Development of a Wearable Passive Vibration Therapy System for the Lower Extremit
    JEFFREY MICHAEL LEISMER; Fiscal Year: 2010
    ..is its ability to passively deliver musculoskeletal stimulation to persons recovering from falls-related hip fractures (e.g., those in a bed rest or other reduced activity environments)...
  7. Community Ambulation Following Hip Fracture
    Jay Magaziner; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: More than 325,000 hip fractures occur annually in the US, with associated health care costs estimated at $14-20 billion...
  8. Improving pain and function in hip fracture
    R Sean Morrison; Fiscal Year: 2013
    b>Hip fractures are an important cause of mortality and functional dependence in the United States...
  9. Genetics of Osteoblast Differentiation
    Matthew Aaron Hibbs; Fiscal Year: 2012
    ..5 million osteoporotic fractures each year, including 280,000 hip fractures and 500,000 vertebral fractures...
  10. Predict Near Future Bed Exit for Effective Intervention to Avoid Nighttime Falls
    THOMAS HENRY WHALEN; Fiscal Year: 2012
    ..The consequences of falls from attempted or successful bed exits among the elderly include hip fractures, soft tissue or head injuries, fear of falling, anxiety, depression and death...
  11. Early effects of PTH on the proximal femur
    Felicia Cosman; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Osteoporosis with consequent hip fractures causes substantial disability, morbidity and mortality...
  12. Glycemic derangement and osteogenic cells:A model of Premature skeletal aging
    KENDALL MOSELEY; Fiscal Year: 2012
    ..Paradoxically, postmenopausal women with type 2 diabetes mellitus (T2DM) are at higher risk for hip fractures despite having higher bone mineral density than women without diabetes...
  13. Clinical Validation of BCT - Phase II
    DAVID KOPPERDAHL; Fiscal Year: 2010
    ..bone geometry and distribution of bone density, body-weight, height, trochanteric soft tissue thickness (for hip fractures), muscle moment arm (for spine), and the age-related risk of sustaining an overload event (such as a fall or ..
  14. Novel Mechanism of PTH Effects on Bone Metabolism
    Bin Wang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Severe osteoporosis affects over 10 million Americans. Over 300,000 hip fractures are caused by osteoporosis annually...
  15. Predictors of Health Care Utilization and Costs Attributable to Hip Fractures
    John T Schousboe; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hip fractures are a leading cause of morbidity and associated health care costs in older people in the United States...
  16. Efficacy of Plyometrics to Increase Bone Mass in Men
    Pamela S Hinton; Fiscal Year: 2011
    ..Osteoporosis is the cause of 85% of all hip fractures and 90% of vertebral fractures in men (31), but, nevertheless, often goes undiagnosed and inadequately treated ..
  17. Causes and Consequences of Healthcare Efficiency
    Jonathan S Skinner; Fiscal Year: 2013
    ..We focus on patient cohorts with hip fractures and AMI, as well as under-age-65 disabled Medicare enrollees, African-Americans, and the oldest-old...
  18. Combining Imaging and Modeling in Osteoporosis Fracture Risk Assessment
    GARY BEAUPRE; Fiscal Year: 2009
    ..morbidity, limitations in the activities of daily living, increased mortality, particularly in the case of hip fractures, and a financial cost to society that is estimated at $19 billion per year or more than $52 million per day...
  19. Predicting Hip Fracture Using a Biomechanical Approach
    Marian T Hannan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hip fractures are a significant cause of disability and mortality in older persons...
  20. COMBINING TESTOSTERONE THERAPY AND EXERCISE TO IMPROVE FUNCTION POST HIP FRACTURE
    Kenneth B Schechtman; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hip fractures are common in elderly women and can have a devastating impact on their ability to remain independent...
  21. Primary Cilia as Mechanotransducers in Bone
    Christopher Rae Jacobs; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hip fractures are the most devastating result of osteoporosis, and for most patients, the first step in downward spiral of lost ambulation, lost independence, institutionalization, and secondary ..
  22. Effects of Practice Redesign on Falls Health Outcomes and Costs
    David B Reuben; Fiscal Year: 2012
    ..approximately 1/3 of older adults fall and approximately 10% of these falls result in major injuries including hip fractures. Although the implementation of falls prevention programs can reduce fall rates, such programs are not widely ..
  23. A NEW SYSTEM FOR ULTRASONIC ASSESSMENT OF THE CALCANEUS
    Jonathan Kaufman; Fiscal Year: 2013
    ..Osteoporosis afflicts over 20 million people in the U.S., and is responsible for more than 275,000 hip fractures annually. Currently, the primary means for assessment relies on densitometric techniques...
  24. Randomized ActiveStep Comparative Effectiveness Trial
    Jon D Lurie; Fiscal Year: 2013
    ..such as tripping are a major contributor to falls and trip-related falls account for as many as 20% of all hip fractures. The ActiveStep(r) fall prevention training program was developed with NIH funding and consists of a series of ..
  25. Hip Fracture Evaluation Alternatives of Total Hip vs Hemi-arthroplasty (HEALTH)
    Thomas A Einhorn; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hip fractures occur in 280,000 Americans, over 5,000 per week...
  26. Turning Difficulty in Parkinson Disease and a Potential Rehabilitation Strategy
    MARIE ELIZABETH MCNEELY; Fiscal Year: 2012
    ..Problems with turning may lead to falls and serious injuries, such as hip fractures. Hip fractures are about eight times more likely to occur when an individual falls during a turn, compared to ..
  27. A New Hip Fracture Risk Prediction Tool Based on Common Predictors and Hip Geomer
    Samy Missoum; Fiscal Year: 2012
    ..b>Hip fractures are the most detrimental type of fractures...
  28. Fixation using Alternative Implants for the Treatment of Hip Fractures: A Multi-c
    Marc F Swiontkowski; Fiscal Year: 2012
    Project Summary Hip fractures occur in 280,000 Americans (over 5,000 per week) and 36,000 Canadians (over 690 per week) annually...
  29. BIOMEDICAL (BASIC)
    Rebecca Jackson; Fiscal Year: 2009
    b>Hip fractures are the most serious outcome of osteoporosis and one of the most disabling consequences of aging...
  30. Continuous Monitoring of Turning in Patients with Parkinson's Disease
    FAY BAHLING HORAK; Fiscal Year: 2013
    ..falling in patients with Parkinson's disease (PD), and is commonly associated with hip fractures. However, asking a PD patient to execute a turn in a clinical environment often does not reveal their ..
  31. Folic Acid and B Vitamins to Prevent Fracture in Women
    Steven Cummings; Fiscal Year: 2009
    ..with elevated plasma homocysteine have a substantially increased risk of osteoporotic fractures, including hip fractures. The next step is to test whether lowering homocysteine levels will reduce the risk of fractures...
  32. OCULOMOTOR CONTROL AND GAIT IN PARKINSON DISEASE
    Gammon M Earhart; Fiscal Year: 2010
    ..times more likely to sustain a hip fracture than age-matched cohorts without PD, and the cost of care for hip fractures in individuals with PD is approximately $192 million per year...
  33. Novel therapy for osteoporosis
    Emma Moore; Fiscal Year: 2009
    ..Osteoporosis is responsible for more than 1.5 million fractures annually, including 300,000 hip fractures, approximately 700,000 vertebral fractures, 250,000 wrist fractures, and more than 300,000 fractures at other ..
  34. Clinical Validation of BCT
    DAVID KOPPERDAHL; Fiscal Year: 2007
    ..bone geometry and distribution of bone density, body-weight, height, trochanteric soft tissue thickness (for hip fractures), and age, thereby shifting focus to the overall structure and mechanics of bone rather than simply density...
  35. FICSIT COLLABORATIVE ANALYSES
    Robert Wallace; Fiscal Year: 1993
    Over 200,000 hip fractures occur in the U.S. yearly among older persons, primarily due to osteoporosis and an increased risk of falls...
  36. FEMORAL OSTEOPOROSIS IN ELDERLY WOMEN
    Susan Greenspan; Fiscal Year: 1999
    Osteoporosis is a widespread condition associated with over 250,000 hip fractures each year...
  37. BONE ESTROGEN STRENGTH TRAINING
    Timothy Lohman; Fiscal Year: 2000
    ..3 million fractures per year. With the increase in the elderly population, a three fold increase in hip fractures, the most costly fracture, has been projected, with costs for treating all osteoporotic fractures increasing ..
  38. VITAMIN D SUPPLEMENTATION IN POSTMENOPAUSAL WOMEN
    John Aloia; Fiscal Year: 2002
    ..Dietary supplementation with vitamin D3 has been shown to safely reduce bone loss and prevent hip fractures in postmenopausal white women...
  39. Testosterone Therapy After Hip Fracture in Elderly Women
    ELLEN BINDER; Fiscal Year: 2005
    DESCRIPTION(provided by applicant): Hip fractures are common among elderly women and can have a devastating impact on their ability to remain independent...
  40. Treatment of Motor Function and Balance- A New Tool
    Lars Oddsson; Fiscal Year: 2006
    ..Furthermore, hip fractures, a common consequence of falls, seriously affect mobility and often leads to early death, especially in the ..
  41. HIP FRACTURE RISK PREDICTION BY QDR
    Wilson Hayes; Fiscal Year: 2000
    DESCRIPTION (Adapted from the applicant's Abstract): Age-related hip fractures are an escalating public health problem, with over 280,000 hip fractures occurring each year in the US and costs in excess of $10 billion...
  42. TESTING A GAPN CARE MODEL FOR ELDERS WITH HIP FRACTURE
    Kathleen Krichbaum; Fiscal Year: 1999
    ..test is justified by: the unchanging mortality rates over the past 20 years among elderly who experience hip fractures; the relatively new deliberate emphasis on Total Quality Management which requires careful explication of the ..
  43. POPULATION-BASED STUDY OF U S HIP FRACTURES
    Alfred Rimm; Fiscal Year: 1990
    ..These estimates will be unique; for the first time in this country they will be based on an enumeration of all hip fractures occurring among the elderly in All regions of the country...
  44. Preventing Osteoporotic Hip Fractures by Accurately Predicting Future Fractures
    CLAUDE ARNAUD; Fiscal Year: 2006
    ..In 2002, the cost of treating hip fractures consumed 63% of the national direct expenditure for OP, or more than $10 billion...
  45. Structural MRI of trabecular bone for therapy response monitoring
    Felix Wehrli; Fiscal Year: 2009
    ..Prevailing among these are the vertebrae, wrist and proximal femur. Hip fractures are the most debilitating among osteoporotic fractures in terms of morbidity and mortality...
  46. NUTRITION, GENES AND HIP FRACTURE RISK IN UTAH
    Ronald Munger; Fiscal Year: 2000
    ..a population-based case-control study of the role of novel nutritional and genetic factors in the etiology of hip fractures in Utah residents, ages 50 years or older...
  47. Inverse Dynamics Using Instrumented Assistive Technology
    W Selbie; Fiscal Year: 2002
    ..reported between 1987 and 1992 which involved walker use and which required emergency room treatment (mostly hip fractures and upper body trauma)...
  48. Trochanteric Padding to Prevent Hip Fractures
    Douglas Kiel; Fiscal Year: 2005
    ..provided by applicant) As measured by their frequency, influence on quality of life and economic cost, hip fractures are a public health problem of crisis proportions...
  49. Predicting Fragilty Fractures Using Hip Radiographs
    CLAUDE ARNAUD; Fiscal Year: 2006
    ..In 2002, the cost of treating hip fractures consumed 63% of the national direct expenditure for OP, or more than $10 billion...
  50. Physical Activity and Hip Fractures in Men
    Diane Feskanich; Fiscal Year: 2009
    ..The investigators on this proposal intend to study physical activity and inactivity in relation to the risk of hip fractures due to low or moderate trauma over a twenty-year period in over 46,000 men in the Health Professionals Follow-..
  51. WHI Sex Hormone & Genetic Risk Factors for Hip Fracture
    Steven Cummings; Fiscal Year: 2005
    In the United States, many hip fractures occur each year, causing significant disability and premature deaths. Cases of hip fractures cost an estimated $7 billion annually...
  52. ANALYSIS OF INJURY AVOIDANCE STRATEGIES DURING FALLS
    Jeffrey Lotz; Fiscal Year: 2002
    At least 280,000 hip fractures occur annually in the U.S., at an estimated cost of $9 billion. While over 90% of these are caused by falls, only about 2% of all falls result in hip fracture...
  53. CASE-CONTROL STUDY OF RISK FACTORS FOR HIP FRACTURE
    JEANE GRISSO; Fiscal Year: 1992
    b>Hip fractures are the most common fracture of older age...
  54. Diet and Risk of Hip Fractures in Men
    Diane Feskanich; Fiscal Year: 2009
    ..The investigators on this proposal intend to study diet in relation to the risk of hip fractures due to low or moderate trauma over a twenty-year period in over 45,000 men in the Health Professionals Follow-..
  55. Implications of in vivo muscle loading for hip fracture etiology
    Dennis Anderson; Fiscal Year: 2009
    ..This information will contribute to understanding of the causes of hip fractures, and in the long term could be used to improve diagnostic and preventive measures, decreasing the incidence of ..
  56. Estrogen regulation of osteoclastogenesis in older men
    Pamela Taxel; Fiscal Year: 2003
    ..Male osteoporosis and hip fractures, primarily diseases of older men, have been poorly studied until recently...
  57. FALL BIOMECHANICS AND HIP FRACTURE RISK
    Wilson Hayes; Fiscal Year: 2004
    ..In addition, of the approximately 300,000 hip fractures that occur each year, over 90% are associated with falls...
  58. LOADING EXERCISE PROGRAMS AND BONE GAIN IN YOUNG WOMEN
    Peter Cavanagh; Fiscal Year: 2000
    ..Low hip bone density is a strong predictor of hip fractures. Thus, the risk of fracture in the elderly is largely determined early in life...
  59. QUANTITATIVE BONE HISTOLOGY AFTER OVARIECTOMY
    Thomas Wronski; Fiscal Year: 1990
    ..bone loss would alleviate orthopedic problems by reducing the incidence of vertebral, wrist, and hip fractures in the elderly female population...
  60. FACTORS AFFECTING RECOVERY FROM HIP SURGERY
    Andrea Barsevick; Fiscal Year: 1992
    ..of elderly people (people recovering from hip replacement surgery and people who have had surgical repair of hip fractures) cope with the problems they encounter at home during the recovery phase after hip surgery. 2...
  61. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    PAULA YIM CHIPLIS; Fiscal Year: 2004
    ..Mobility disability is predictive of more severe disablement, including falls, hip fractures, recurrent hospitalizations and institutionalization...
  62. Propoxyphene Use in the Aged: Predictors and Outcomes
    Sachin Kamal Bahl; Fiscal Year: 2003
    ..Only two studies have assessed the risk of hip fractures with propoxyphene use; both used non-U.S. databases and have several limitations...
  63. FUNCTIONAL OUTCOMES IN PATIENTS WITH HIP FRACTURES
    Albert Siu; Fiscal Year: 2000
    ..Sinai School of Medicine proposes a five-year longitudinal study to address the outcomes and management of hip fractures in the Mount Sinai Health System in New York City...
  64. Combining data types in meta analysis
    Michael Borenstein; Fiscal Year: 2004
    ..in the elderly, perceptions of the elderly, disease prevention in the elderly, bone density loss and hip fractures, stroke, heart disease and aneurysms, and Parkinson's Disease, among many others...