foreign body reaction

Summary

Summary: Chronic inflammation and granuloma formation around irritating foreign bodies.

Top Publications

  1. ncbi Polypropylene in the intra-abdominal position: influence of pore size and surface area
    J Conze
    Department of Surgery, Rhenish Westphalian Technical University, Pauwelsstrasse 30, 52074 Aachen, Germany
    Hernia 8:365-72. 2004
  2. pmc Foreign body reaction to biomaterials
    James M Anderson
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, United States
    Semin Immunol 20:86-100. 2008
  3. ncbi The correlation between difference in foreign body reaction between implant locations and cytokine and MMP expression
    Daniel T Luttikhuizen
    Department of Pathology and Laboratory Medicine, Medical Biology Section, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Biomaterials 27:5763-70. 2006
  4. ncbi Cellular and molecular dynamics in the foreign body reaction
    Daniel T Luttikhuizen
    Department of Pathology and Laboratory Medicine, Medical Biology Division, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Tissue Eng 12:1955-70. 2006
  5. ncbi The topographical effect of electrospun nanofibrous scaffolds on the in vivo and in vitro foreign body reaction
    Haoqing Cao
    School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637459
    J Biomed Mater Res A 93:1151-9. 2010
  6. ncbi Reduced foreign body reaction to implanted biomaterials by surface treatment with oriented osteopontin
    Lingyun Liu
    Department of Bioengineering, University of Washington, Seattle, WA 98195, USA
    J Biomater Sci Polym Ed 19:821-35. 2008
  7. ncbi The recruitment of primitive Lin(-) Sca-1(+), CD34(+), c-kit(+) and CD271(+) cells during the early intraperitoneal foreign body reaction
    Ilse Vranken
    Laboratory of Experimental Cardiac Surgery, Department of Cardiovascular Diseases, KU, Leuven, Minderbroedersstraat 17, 3000 Leuven, Belgium
    Biomaterials 29:797-808. 2008
  8. pmc Mice that lack the angiogenesis inhibitor, thrombospondin 2, mount an altered foreign body reaction characterized by increased vascularity
    T R Kyriakides
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 96:4449-54. 1999
  9. ncbi Matrix metalloproteinases and their inhibitors in the foreign body reaction on biomaterials
    Jacqueline A Jones
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biomed Mater Res A 84:158-66. 2008
  10. pmc The foreign body reaction in T-cell-deficient mice
    Analiz Rodriguez
    Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biomed Mater Res A 90:106-13. 2009

Detail Information

Publications246 found, 100 shown here

  1. ncbi Polypropylene in the intra-abdominal position: influence of pore size and surface area
    J Conze
    Department of Surgery, Rhenish Westphalian Technical University, Pauwelsstrasse 30, 52074 Aachen, Germany
    Hernia 8:365-72. 2004
    ..The following study was designed to investigate the adhesive potential of different polypropylene meshes when placed in direct contact with intestine...
  2. pmc Foreign body reaction to biomaterials
    James M Anderson
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, United States
    Semin Immunol 20:86-100. 2008
    The foreign body reaction composed of macrophages and foreign body giant cells is the end-stage response of the inflammatory and wound healing responses following implantation of a medical device, prosthesis, or biomaterial...
  3. ncbi The correlation between difference in foreign body reaction between implant locations and cytokine and MMP expression
    Daniel T Luttikhuizen
    Department of Pathology and Laboratory Medicine, Medical Biology Section, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Biomaterials 27:5763-70. 2006
    The foreign body reaction (FBR) differs between subcutaneously and supra-epicardially implanted materials. We hypothesize that this is a result of differences in cytokine, chemokine and matrix metalloproteinase (MMP) dynamics...
  4. ncbi Cellular and molecular dynamics in the foreign body reaction
    Daniel T Luttikhuizen
    Department of Pathology and Laboratory Medicine, Medical Biology Division, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Tissue Eng 12:1955-70. 2006
    ..This inflammatory reaction to implanted materials is known as the foreign body reaction (FBR) and is characterized by 3 distinct phases: onset, progression, and resolution...
  5. ncbi The topographical effect of electrospun nanofibrous scaffolds on the in vivo and in vitro foreign body reaction
    Haoqing Cao
    School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637459
    J Biomed Mater Res A 93:1151-9. 2010
    ..to scaffold architecture and topographical effect of nanofibrous scaffolds on the in vivo and in vitro foreign body reaction. Random and aligned polycaprolactone (PCL) nanofibers were fabricated by electrospinning technique, with ..
  6. ncbi Reduced foreign body reaction to implanted biomaterials by surface treatment with oriented osteopontin
    Lingyun Liu
    Department of Bioengineering, University of Washington, Seattle, WA 98195, USA
    J Biomater Sci Polym Ed 19:821-35. 2008
    The foreign body reaction (FBR), which leads to the encapsulation of implanted biomaterials, has been implicated in the failure of many medical devices...
  7. ncbi The recruitment of primitive Lin(-) Sca-1(+), CD34(+), c-kit(+) and CD271(+) cells during the early intraperitoneal foreign body reaction
    Ilse Vranken
    Laboratory of Experimental Cardiac Surgery, Department of Cardiovascular Diseases, KU, Leuven, Minderbroedersstraat 17, 3000 Leuven, Belgium
    Biomaterials 29:797-808. 2008
    ..materials, such as medical devices, provoke the body to initiate an inflammatory reaction, known as the foreign body reaction (FBR), which causes several complications for example in hip prostheses, silicone implants, peritoneal ..
  8. pmc Mice that lack the angiogenesis inhibitor, thrombospondin 2, mount an altered foreign body reaction characterized by increased vascularity
    T R Kyriakides
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 96:4449-54. 1999
    ..Consideration of this phenotype suggested to us that the foreign body reaction (FBR) might be altered in thrombospondin 2 (TSP2)-null mice...
  9. ncbi Matrix metalloproteinases and their inhibitors in the foreign body reaction on biomaterials
    Jacqueline A Jones
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biomed Mater Res A 84:158-66. 2008
    ..e., adhesion and migration) and subsequent pathological responses (i.e., the foreign body reaction and wound healing)...
  10. pmc The foreign body reaction in T-cell-deficient mice
    Analiz Rodriguez
    Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biomed Mater Res A 90:106-13. 2009
    ..We have shown that there are pathways that do not require thymus-matured T lymphocytes, which lead to a normal foreign body response to biomaterials in a murine model...
  11. pmc Inhibition of methylcholanthrene-induced carcinogenesis by an interferon gamma receptor-dependent foreign body reaction
    Zhihai Qin
    Institute of Immunology, Free University Berlin, 12200 Berlin, Germany
    J Exp Med 195:1479-90. 2002
    The foreign body reaction is one of the oldest host defense mechanisms against tissue damage which involves inflammation, scarring, and encapsulation...
  12. doi eComment: Foreign body reaction to polytetrafluoroethylene
    Murat Ozeren
    Mersin University Medical Faculty Department of Cardiovascular Surgery, Mersin 33079, Turkey
    Interact Cardiovasc Thorac Surg 7:276-7. 2008
  13. ncbi Foreign body reaction to artelon spacer: case report
    A Ylenia Giuffrida
    Departments of Hand Surgery and Pathology, Hospital for Special Surgery, New York, NY 10021, USA
    J Hand Surg Am 34:1388-92. 2009
    ..Patients should be made aware of the potential of the Artelon spacer to cause a foreign body reaction that may necessitate reoperation for removal of the implant.
  14. ncbi Biocompatibility of two novel dermal fillers: histological evaluation of implants of a hyaluronic acid filler and a polyacrylamide filler
    Sergio Fernández-Cossío
    Department of Plastic and Reconstructive Surgery, Clinical University Hospital, Santiago de Compostela, Spain
    Plast Reconstr Surg 117:1789-96. 2006
    ..Recently, hyaluronic acid and polyacrylamide gel products have been introduced as dermal fillers. Both types of product are widely considered to be biocompatible...
  15. ncbi Outbreak of Mycobacterium abscessus infection after soft tissue augmentation
    Brian R Toy
    Department of Dermatology, New York University Medical Center, 560 1st Avenue, H 100, New York, NY 10016, USA
    Dermatol Surg 29:971-3. 2003
    ..Illicit soft-tissue augmentation performed in New York City resulted in an outbreak of Mycobacterium abscessus infection in 2002...
  16. ncbi Characterization of materials eliciting foreign body reaction in stapled human gastrointestinal anastomoses
    C B B Lim
    Department of Biosurgery and Surgical Technology, St Mary s Hospital, Imperial College London, London, UK
    Br J Surg 95:1044-50. 2008
    Staples are made of titanium, which elicits minimal tissue reaction. The authors have encountered foreign body reaction associated with stapled human gastrointestinal anastomoses, although the literature has no reports of this...
  17. ncbi The downmodulation of the foreign body reaction by cytomegalovirus encoded interleukin-10
    S M van Putten
    Department of Pathology and Medical Biology, University of Groningen, University Medical Centre Groningen, Hanzeplein 1, EA11, 9713 GZ Groningen, The Netherlands
    Biomaterials 30:730-5. 2009
    The foreign body reaction (FBR) is of great importance for the function and turnover of biomaterial scaffolds...
  18. ncbi Foreign body reaction after usage of tissue adhesives for skin closure: a case report and review of the literature
    Adrian Dragu
    Department of Plastic and Hand Surgery, University of Erlangen Nurnberg, University Clinic, Krankenhausstrasse 12, 91054 Erlangen, Germany
    Arch Orthop Trauma Surg 129:167-9. 2009
    ..However, so far the risks and possible complications after using 2-octyl cyanoacrylate are not sufficiently published and discussed...
  19. ncbi Foreign body reaction to anorganic bovine bone and autogenous bone with platelet-rich plasma in guided bone regeneration
    Sharon R Bannister
    U S Air Force Periodontics Residency, Periodontics Flight, 59th Dental Training Squadron, Wilford Hall Medical Center, Lackland Air Force Base, TX, USA
    J Periodontol 79:1116-20. 2008
    ..Although many materials may be used for these procedures, the outcome is usually predictable. In this report, we present an unusual reaction to a frequently used commercially available xenograft material...
  20. ncbi A foreign body reaction to Surgicel mimicking an abscess following cardiac surgery
    Mohamed F Ibrahim
    Eur J Cardiothorac Surg 22:489-90; author reply 490. 2002
  21. pmc Compromised production of extracellular matrix in mice lacking secreted protein, acidic and rich in cysteine (SPARC) leads to a reduced foreign body reaction to implanted biomaterials
    Pauli Puolakkainen
    Department of Vascular Biology, The Hope Heart Institute, University of Washington, Seattle, Washington 98104, USA
    Am J Pathol 162:627-35. 2003
    ..Herein we asked whether SPARC might influence the foreign body reaction to biomaterial implants...
  22. ncbi Foreign body reaction to calcium hydroxylapatite after lip augmentation
    Vidya Sankar
    Department of Dental Diagnostic Science, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail Code 7919, San Antonio, Texas 78229, USA
    J Am Dent Assoc 138:1093-6. 2007
    ..Common side effects detected on clinical examination may include edema, bruising and noninflammatory lip nodules...
  23. ncbi Surgery for foreign body reactions due to injectable fillers
    Dolores Wolfram
    Department of Plastic and Reconstructive Surgery, Medical University of Innsbruck, Innsbruck, Austria
    Dermatology 213:300-4. 2006
    ..Depending on bioavailability, chemical composition and degradation, fillers can be classified as temporary or permanent, organic or inorganic and autologous or heterologous...
  24. ncbi Bone wax as a cause of foreign body reaction after lumbar disc surgery: a case report
    Olcay Eser
    Neurosurgery Department, Kocatepe University, Afyonkarahisar, Turkey
    Adv Ther 24:594-7. 2007
    ..Bone wax use should be limited in spinal surgery because of the potential for compression and chronic inflammation...
  25. ncbi Long-term tissue response to bioabsorbable poly-L-lactide and metallic screws: an experimental study
    Harri Pihlajamaki
    Research Institute of Military Medicine, Central Military Hospital, Helsinki, Finland
    Bone 39:932-7. 2006
    ..The results of this study showed no significant differences between the bioabsorbable PLLA screws and the metallic screws in biocompatibility, and no signs of inflammatory foreign-body reactions occurred during the follow-up...
  26. ncbi Persistent foreign body reaction around inguinal mesh prostheses: a potential pitfall of FDG PET
    Nicolas Aide
    Hôpitaux de Paris PET Center, Hopital Tenon, 4 rue de la Chine, 75020 Paris, France
    AJR Am J Roentgenol 184:1172-7. 2005
    ..The purpose of this study is to describe three oncology patients with persistent FDG up-take around inguinal mesh prostheses that occurred up to 10 years after the surgical repair of inguinal hernias and led to false-positive results...
  27. ncbi Foreign body reaction involving a Mantoux test site
    Youngjin Kim
    Department of Dermatology, Concord Hospital, Sydney, New South Wales, Australia
    Australas J Dermatol 46:169-71. 2005
    ..We postulate that the reaction in our patient may have been secondary to the implantation of epidermal keratin or the entrapment of hair into the dermis during the intradermal injection of tuberculin purified protein derivative...
  28. ncbi Rectal stenosis caused by foreign body reaction to sodium polystyrene sulfonate crystals (Kayexalate)
    Denis Chatelain
    Department of Pathology, Centre Hospitalo Universitaire Amiens, Place Victor Pauchet, 80054 Amiens Cedex 1, France
    Ann Diagn Pathol 11:217-9. 2007
    ..This is the first case report of rectal stenosis caused by foreign body reaction to SPS crystals after ischemic colitis.
  29. ncbi Facial augmentation with porous polyethylene (Medpor)--histological evidence of intense foreign body reaction
    Martin Gosau
    Clinic for Craniomaxillofacial Surgery, University of Munich, Lindwurmstr 2a, 80337 Munich, Germany
    J Biomed Mater Res B Appl Biomater 87:83-7. 2008
    ..Medpor implants as augmentation material in the facial skeleton, we examined cases with unexpected intense foreign body reaction and focal disintegration of the implant material...
  30. ncbi Hylan G-F 20 induces delayed foreign body inflammation in Guinea pigs and rabbits
    Masanori Sasaki
    Central Research Laboratories, Seikagaku Corporation, Tokyo, Japan
    Toxicol Pathol 31:321-5. 2003
    ..The present results contradict previous reports on biocompatibility of hylan and suggest that hylan may potentially induce similar unfavorable reactions in humans...
  31. ncbi Neovascularization and vascular markers in a foreign body reaction to subcutaneously implanted degradable biomaterial in mice
    Machteld J van Amerongen
    Laboratory for Tissue Engineering, Department of Pathology and Laboratory Medicine, Medical Biology Section, Groningen University, Institute for Drug Exploration GUIDE, Groningen, The Netherlands
    Angiogenesis 5:173-80. 2002
    To study the spatiotemporal processes of angiogenesis during a foreign body reaction (FBR), biodegradable bovine collagen type-1 (COL-I) discs were implanted in mice for a period up to 28 days...
  32. ncbi A histologic study of adverse effects of different cosmetic skin fillers
    Meire B Parada
    Department of Dermatology, Federal University of Sao Paulo, Sao Paulo, Brazil
    Skinmed 4:345-9. 2005
    ..This study was designed to describe the histologic aspects of the cutaneous and mucosal adverse reactions to fillers used for cosmetic purposes...
  33. ncbi [Foreign body reaction to materials implanted as biocompatible for internal fixation]
    Alexander Thiele
    Klinik fur Hals, Nasen und Ohrenheilkunde, Kopf und Halschirurgie der Martin Luther Universität Halle Wittenberg, Magdeburger Strasse 12, 06112 Halle Saale
    HNO 56:545-8. 2008
    ..patients had a midfacial fracture, which we fixed using a resorbable system based on PLLA-PGA (82%-18%); a foreign body reaction developed after 22 months...
  34. ncbi Tissue response to partially in vitro predegraded poly-L-lactide implants
    Wim H De Jong
    Laboratory for Toxicology, Pathology and Genetics, National Institute for Public Health and the Environment, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Biomaterials 26:1781-91. 2005
    ..0-2.0 mm thickness should be used as these may show a more realistic representation of the resorption characteristics of the material under investigation...
  35. ncbi Host response after reconstruction of abdominal wall defects with porcine dermal collagen in a rat model
    Fang Zheng
    Center for Surgical Technologies, Faculty of Medicine, University Hospitals Leuven, Katholieke Universiteit Leuven, Leuven, Belgium
    Am J Obstet Gynecol 191:1961-70. 2004
    ..The purpose of this study was to compare the inflammatory response after implantation of Pelvicol with Prolene in a rat model...
  36. ncbi Phospholipase A2 pathway association with macrophage-mediated polycarbonate-urethane biodegradation
    Donna Lee M Dinnes
    University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ont, K1Y 4W7, Canada
    Biomaterials 26:3881-9. 2005
    ..Understanding PCNU activation of intracellular pathways, such as PLA2, will allow the design of materials optimized for their intended use...
  37. ncbi Tissue reactions of in situ formed dextran hydrogels crosslinked by stereocomplex formation after subcutaneous implantation in rats
    Gert W Bos
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, P O Box 80 082, 3508 TB Utrecht, The Netherlands
    Biomaterials 26:3901-9. 2005
    ..The tissue reaction was evaluated over a period of 30 days. A mild ongoing foreign body reaction was observed characterized by infiltration of macrophages...
  38. ncbi Tissue response to poly-L-lactide acid-polyglycolic acid absorbable screws in autogenous bone grafts: a histologic morphological analysis
    Mariza Akemi Matsumoto
    Department of Oral and Maxillofacial Surgery, Universidade do Sagrado Coração, Rua Rio Branco 19 79, Altos da Cidade, 17014 480 Bauru São Paulo, Brazil
    Clin Oral Implants Res 16:112-8. 2005
    ..To evaluate the local bone condition of autogenous chin grafts in contact with resorbable polymers fixation devices...
  39. ncbi [Influence of intraocular lens material and design on the development of posterior capsule opacification]
    O Nishi
    Nishi Eye Hospital, Osaka, Japan
    Ophthalmologe 102:572-8. 2005
    ..Optimization of design and material of an IOL, which facilitates capsular bend formation as sharply and quickly as possible, may reduce PCO to a clinically negligible level...
  40. ncbi The effect of scaffold degradation rate on three-dimensional cell growth and angiogenesis
    Hak Joon Sung
    Wallace Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, 101 Woodruff Circle WMB 2304, Atlanta, GA 30332 0363, USA
    Biomaterials 25:5735-42. 2004
    ..Again, PLGA scaffolds demonstrated less cell mobilization and less angiogenesis, further supporting the negative effect of the acidic environment created by the degradation of biocompatible polymers...
  41. ncbi Comparison between textured silicone implants and those bonded with expanded polytetrafluoroethylene in rats
    Douglas Haddad Filho
    Division of Plastic Surgery, UNISA, Sao Paulo, Brazil
    Acta Cir Bras 22:187-94. 2007
    ..Comparison of the inflammatory reaction promoted by textured silicone implants and that caused by the implant bonded with e-ptfe...
  42. ncbi Development and cell response of a new biodegradable composite scaffold for guided bone regeneration
    M Navarro
    CREB Biomedical Engineering Research Center, Department of Material Science and Metallurgy, Technical University of Catalonia, Avda Diagonal 647, 08028 Barcelona, Spain
    J Mater Sci Mater Med 15:419-22. 2004
    ..5 to 120 KPa and the compressive strength from 17.5 to 20.1 KPa for the PLA and the PLA/glass foams, respectively. The biological response was evaluated by means of the MTT test, the materials resulted to be noncytotoxic...
  43. ncbi Mechanical and biological properties of hydroxyapatite reinforced with 40 vol. % titanium particles for use as hard tissue replacement
    Chenglin Chu
    Department of Mechanical Engineering, Southeast University, Nanjing 210018, China
    J Mater Sci Mater Med 15:665-70. 2004
    ..Ti composite has excellent biocompatibility and could integrate with bone. In the early stage after the implantation of the samples, the osteointegration ability of the composite is better than that of pure titanium...
  44. ncbi The quantification of cellular viability and inflammatory response to stainless steel alloys
    LeeAnn O Bailey
    Polymers Division, National Institute of Standards and Technology, Gaithersburg, MD 20899 8545, USA
    Biomaterials 26:5296-302. 2005
    ..Using these techniques, we observed evidence for an association between the upregulation of IL-1beta and reversible apoptosis, and the upregulation of TNF-alpha and irreversible apoptosis...
  45. ncbi Injectable biomaterials for incontinence and vesico-ureteral reflux: current status and future promise
    Chi Chun Tsai
    Alcon Research, Ltd, 6201 South Freeway, Mail Stop R1 18, Fort Worth, Texas 76134, USA
    J Biomed Mater Res B Appl Biomater 77:171-8. 2006
    ..Here we report some recent results for supporting this hypothesis...
  46. ncbi Material dependent differences in inflammatory gene expression by giant cells during the foreign body reaction
    D T Luttikhuizen
    Department of Pathology and Laboratory Medicine, Medical Biology Section, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    J Biomed Mater Res A 83:879-86. 2007
    Multinucleated giant cells (GCs) are often observed in the foreign body reaction against implanted materials. The in vivo function of GCs in this inflammatory process remains to be elucidated...
  47. ncbi Experimental comparison of monofile light and heavy polypropylene meshes: less weight does not mean less biological response
    Grigoris Chatzimavroudis
    World J Surg 31:865; author reply 866. 2007
  48. ncbi Photo-polymerized microarchitectural constructs prepared by microstereolithography (muSL) using liquid acrylate-end-capped trimethylene carbonate-based prepolymers
    Il Keun Kwon
    Division of Biomedical Engineering, Graduate School of Medicine, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Biomaterials 26:1675-84. 2005
    ..In this paper, we discuss their potential biomedical applications...
  49. ncbi Should in the treatment of osteochondritis dissecans biodegradable or metallic fixation devices be used? A comparative study in goat knees
    Diederick B Wouters
    Department of General, Arthroscopical Surgery and Traumatology, TweeSteden Hospital, Dr Deelenlaan 5, 5042 AD, Tilburg, The Netherlands
    J Biomed Mater Res B Appl Biomater 84:154-64. 2008
    ..This screw has to be removed before loading the limb to prevent cartilage wear of the opposite tibia plateau...
  50. ncbi Degradation of poly-L-lactide. Part 1: in vitro and in vivo physiological temperature degradation
    N A Weir
    School of Mechanical and Manufacturing Engineering, Queen s University Belfast, Belfast, UK
    Proc Inst Mech Eng H 218:307-19. 2004
    ..Additionally, the absence of cells marking an inflammatory response suggests that the PLLA rods investigated in vivo were biocompatible throughout the 44 weeks duration of the study, before any mass loss was observed...
  51. ncbi Biological properties of the intervertebral cages made of titanium containing a carbon-carbon composite covered with different polymers
    V Pesakova
    Rheumatological Institute Na Slupi 4, Prague 2, 128 50, Czech Republic
    J Mater Sci Mater Med 16:143-8. 2005
    ..Modification of the composite HEMA with the use of collagen seems to have a more positive effect on the new bone tissue formed around the implanted devices than HEMA copolymerized with methylmethacrylate or terc-butylmethacrylamide...
  52. ncbi Biocatalytic synthesis of highly ordered degradable dextran-based hydrogels
    Lino Ferreira
    Departamento de Engenharia Quimica, Universidade de Coimbra, Pinhal de Marrocos, 3030 Coimbra, Portugal
    Biomaterials 26:4707-16. 2005
    ..These combined properties may offer competitive advantages in biomedical applications ranging from tissue engineering to controlled drug delivery...
  53. ncbi Antioxidant inhibition of poly(carbonate urethane) in vivo biodegradation
    Elizabeth M Christenson
    Center for Applied Polymer Research, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biomed Mater Res A 76:480-90. 2006
    ..Therefore, it was concluded that the antioxidant inhibited degradation by capturing oxygen radicals that would otherwise cause polyurethane chain scission and crosslinking...
  54. ncbi Polypropylene midurethral tapes do not have similar biologic and biomechanical performance in the rat
    Tony M Bazi
    Department of Obstetrics and Gynecology, American University of Beirut, Beirut, Lebanon
    Eur Urol 51:1364-73; discussion 1373-5. 2007
    ..To evaluate the biomechanical properties and histologic changes of different commercially available polypropylene midurethral tapes (MUTs) after implantation in the rat...
  55. ncbi Liver tissue responses to gelatin and gelatin/chitosan gels
    Xiaohong Wang
    Key Laboratory for Advanced Manufacturing by Materials Processing Technology and Center of Organ Manufacturing, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, People s Republic of China
    J Biomed Mater Res A 87:62-8. 2008
    ..Advanced biodegradation of the gelatin gels was observed. These data indicate that the gelatin gel has better liver tissue biocompatibility and a faster biodegraded rate than the gelatin/chitosan gel...
  56. ncbi Collagen foil (TissuFoil E) reduces the formation of adhesions when using polypropylene mesh for the repair of experimental abdominal wall defects
    Frank Schönleben
    Chirurgische Klinik mit Poliklinik der Universität Erlangen Nürnberg, Krankenhausstr 12, 91054 Erlangen, Germany
    Int J Colorectal Dis 21:840-6. 2006
    ..Severe adhesions are a common cause of intestinal obstruction, or even intestinal fistulas. Using a porcine model, we investigated whether applying a collagen foil (CF) to the undersurface of a PPM will reduce adhesion formation...
  57. ncbi In vivo studies of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) based polymers: biodegradation and tissue reactions
    Xiang Hua Qu
    Department of Biological Science and Biotechnology, Tsinghua University, Beijing 100084, China
    Biomaterials 27:3540-8. 2006
    ..Pronounced tissue responses were observed in the capsule surrounding E1X1 and E1X5 as characterized by the presence of lymphocytes, eosinophils and vascularization, which might be resulted from the continuous leaching of PEG...
  58. ncbi Particle-induced osteolysis in three-dimensional micro-computed tomography
    Christian Wedemeyer
    Department of Orthopedics, University of Duisburg Essen, Hufelandstr 55, 45122 Essen, Germany
    Calcif Tissue Int 81:394-402. 2007
    ..These irregularities seen by micro-CT analysis provide new insight into individual bone changes which might otherwise be overlooked by histological analysis and can be used as baseline information on which future studies can be designed...
  59. ncbi One-year results of use of poly-L/D-lactic acid joint scaffolds and bone packing in revision metacarpophalangeal arthroplasty
    M Ikävalko
    Rheumatism Foundation Hospital, Heinola, Finland
    J Hand Surg Eur Vol 32:427-33. 2007
    ..This article presents the one-year results of a prospective, non-randomised clinical and radiographic follow-up study of 21 patients with 52 revision metacarpophalangeal arthroplasties using the PLDLA implants and allograft bone packing...
  60. ncbi Experimental comparison of monofile light and heavy polypropylene meshes: less weight does not mean less biological response
    Dirk Weyhe
    Department of Surgery, St Josef Hospital, Ruhr University, Bochum, Germany
    World J Surg 30:1586-91. 2006
    ..It is believed that biocompatibility of meshes may be improved by reducing their weight per meter squared (m2) and altering the implant structure...
  61. ncbi Influence of hernioplastic implants on male fertility in rats
    T Kolbe
    Institute of Laboratory Animal Science and Research Center Biomodels, University of Veterinary Medicine, Vienna, Austria
    J Biomed Mater Res B Appl Biomater 81:435-40. 2007
    ..Both types of hernioplastic implants tested in this investigation do not give an indication of a negative influence on male fertility in juvenile or adult rats...
  62. ncbi Tensile strength and host response towards silk and type i polypropylene implants used for augmentation of fascial repair in a rat model
    Federico Spelzini
    Centre for Surgical Technologies, Faculty of Medicine, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Gynecol Obstet Invest 63:155-62. 2007
    ..We compared host response, architectural integration and tensile strength of two different macroporous silk constructs to a polypropylene type I implant in a rat model for augmentation of primary fascial defect repair...
  63. ncbi Urokinase-immobilization suppresses inflammatory responses to polyurethane tubes implanted in rabbit muscles
    Zhong Fang Lai
    Department of Pharmacology and Molecular Therapeutics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    J Biomed Mater Res A 76:81-5. 2006
    ....
  64. ncbi Characterization of mode II-wear particles and cytokine response in a human macrophage-like cell culture
    Olaf Rolf
    Department of Orthopedics, König Ludwig Haus, University of Wurzburg, Brettreichstr 11, D 97074 Wurzburg, Germany
    Biomed Tech (Berl) 50:25-9. 2005
    ..The aim of this study was to characterize wear particles obtained intraoperatively and to analyse their effects on cytokine response in an established human macrophage-like cell culture model...
  65. ncbi Degenerative mineralization in the fibrous capsule of silicone breast implants
    André P Legrand
    Laboratoire de Physique Quantique, ESPCI, 10 rue Vauquelin, 75005, Paris, France
    J Mater Sci Mater Med 16:477-85. 2005
    ..Whatever the characteristics of any sophisticated new model of breast implant, phenomenon of mineralization might be minimized but it is very unlikely that it would be totally eliminated...
  66. ncbi [Evaluation of nonabsorbable surgical sutures in tubal anastomoses with use of microsurgical techniques. An experimental study]
    Marek Murawski
    I Katedra i Klinika Ginekologii i Poloznictwa Akademii Medycznej we Wrocławiu
    Polim Med 37:57-66. 2007
    ..The analyzed surgical sutures characterize themselves of very good usefulness to microsurgical operations of oviducts...
  67. ncbi [New methods for the prevention of posterior capsule opacification]
    G U Auffarth
    Augenklinik, Ruprecht Karls Universitat, Heidelberg
    Ophthalmologe 102:579-86. 2005
    ..This survey gives an update on current and future means and trends to reduce or prevent PCO formation...
  68. ncbi In vivo degradation of poly(DTE carbonate) membranes. Analysis of the tissue reactions and mechanical properties
    Antti J Asikainen
    Department of Oral and Maxillofacial Surgery, University of Helsinki, Helsinki, Finland
    J Mater Sci Mater Med 19:53-8. 2008
    ..Based on this study, it can be concluded that poly(DTE carbonate) elicited a very modest foreign body reaction in the soft tissues. This reaction was uniform throughout the study...
  69. ncbi Experimental comparison of monofile light and heavy polypropylene meshes: less weight does not mean less biological response
    U Klinge
    World J Surg 31:867-8; author reply 869-70. 2007
  70. ncbi Improving outcomes in hernia repair by the use of light meshes--a comparison of different implant constructions based on a critical appraisal of the literature
    Dirk Weyhe
    Department of Surgery, St Josef Hospital, Ruhr University Bochum, Gudrunstr 56, 44791, Bochum, Germany
    World J Surg 31:234-44. 2007
    ..This overview of the literature aimed to establish whether absolute material reduction (g per implanted mesh), use of absorbable components, and coating by inert materials are evidence-based ways to improve biocompatibility of meshes...
  71. ncbi In vitro release of insulin and biocompatibility of in situ forming gel systems
    Feirong Kang
    Department of Pharmaceutical Sciences, College of Pharmacy, North Dakota State University, Fargo, ND 58105, USA
    Int J Pharm 304:83-90. 2005
    ..The results suggested that in situ forming gel system was biocompatible...
  72. ncbi Clinical experience with metal-on-metal total joint replacements: indications and results
    I D Learmonth
    Department of Orthopaedic Surgery, University of Bristol, Bristol Royal Infirmary, Bristol, UK
    Proc Inst Mech Eng H 220:229-37. 2006
    ..Several researchers have reported excellent mid-term results with the current generation of high-precision metal-on-metal bearings...
  73. ncbi Polydimethylsiloxane versus polytetrafluoroethylene for vocal fold medialization: histologic evaluation in a rabbit model
    Miguel Caballero
    Department of Otorhinolaryngology, Hospital Clinic of Barcelona, Spain
    J Biomed Mater Res B Appl Biomater 67:666-74. 2003
    ..Due to this histological reaction, silicone particles present greater anchorage and stability...
  74. ncbi In vivo studies comparing the biocompatibility of various polypropylene meshes and their handling properties during endoscopic total extraperitoneal (TEP) patchplasty: an experimental study in pigs
    H Scheidbach
    Department of Surgery, Otto von Guericke University Magdeburg, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Surg Endosc 18:211-20. 2004
    ..We tested several recently modified PP meshes to evaluate them in terms of their biocompatibility and handling characteristics during minimally invasive procedures...
  75. ncbi The inflammatory cell influx and cytokines changes during transition from acute inflammation to fibrous repair around implanted materials
    Christina Gretzer
    Institute of Surgical Sciences, The Sahlgrenska Academy at Goteborg University, SE 405 30 Goteborg, Sweden
    J Biomater Sci Polym Ed 17:669-87. 2006
    ....
  76. ncbi Tissue response to expanded polytetrafluoroethylene and silicone implants in a rabbit model
    Rami K Batniji
    Division of Otolaryngology, Albany Medical Center, 47 New Scotland Ave, Albany, NY 12208, USA
    Arch Facial Plast Surg 4:111-3. 2002
    ..Expanded polytetrafluoroethylene (ePTFE) and silicone are safe and relatively biocompatible materials...
  77. ncbi Tissue responses to Hydron, assessed by intramuscular implantation
    R J Reid
    The University of Adelaide, South Australia
    Int Endod J 25:199-204. 1992
    ..The amount of apparently calcified material increased with time. Inflammation was not a prominent tissue response for any of the test materials, nor was a foreign body giant cell response...
  78. ncbi Homologous collagen dispersion (dermalogen) as a dermal filler: persistence and histology compared with bovine collagen
    Anthony P Sclafani
    Division of Facial Plastic and Reconstructive Surgery, The New York Eye and Ear Infirmary, New York, NY 10003, USA
    Ann Plast Surg 49:181-8. 2002
    ..For these reasons, the authors think Dermalogen is a reasonable alternative to bovine collagen for facial soft-tissue augmentation...
  79. ncbi Tissue response and biomaterial integration: the efficacy of in vitro methods
    C J Kirkpatrick
    Institute of Pathology, Johannes Gutenberg University, Langenbeckstr 1, D 55101 Mainz, Germany
    Biomol Eng 19:211-7. 2002
    ....
  80. ncbi A preliminary report on the biocompatibility of photopolymerizable semi-interpenetrating anhydride networks
    Venkatram Prasad Shastri
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Biomaterials 25:715-21. 2004
    ....
  81. ncbi [Development of better tolerated prosthetic materials: applications in gynecological surgery]
    P Debodinance
    Service de Gynecologie Obstetrique, CH Dunkerque, 43, rue des Pinsons, 59430 Saint Pol sur Mer, France
    J Gynecol Obstet Biol Reprod (Paris) 31:527-40. 2002
    ..Our personal experience with 87 repair procedures has led us to the conclusion that Prolene is the most adapted mesh, allowing free tension between the bladder and the anterior vaginal wall...
  82. ncbi Biological reactivity of zirconia-hydroxyapatite composites
    Viviane V Silva
    CNEN CDTN Comissão Nacional de Energia Nuclear Centro de Desenvolvimento de Tecnologia Nuclear, R Prof Mário Werneck, S N, Cidade Universitaria, Pampulha, Belo Horizonte, MG, CP 941, CEP 30123 970, Brazil
    J Biomed Mater Res 63:583-90. 2002
    ....
  83. ncbi Tissue response to a newly developed calcium phosphate cement containing succinic acid and carboxymethyl-chitin
    Atsuro Yokoyama
    Department of Oral Functional Science, Hokkaido University Graduate School of Dental Medicine, Kita 13 Nishi 7 Kita ku, Sapporo 060 8586, Japan
    J Biomed Mater Res A 64:491-501. 2003
    ..Analysis by X-ray diffraction showed that the new cement in the subcutaneous tissue was transformed into hydroxyapatite by 8 weeks. These results indicate that this new calcium phosphate cement is useful as a bone substitute material...
  84. ncbi Modification of inflammatory response to implanted biomedical materials in vivo by surface bound superoxide dismutase mimics
    K Udipi
    MetaPhore Pharmaceuticals, Inc, 1910 Innerbelt Business Center Drive, St. Louis, Missouri 63114, USA
    J Biomed Mater Res 51:549-60. 2000
    ..A mechanism based on our current understanding of superoxide as an inflammatory mediator at implanted biomedical materials is proposed...
  85. ncbi Chronic response of adult rat brain tissue to implants anchored to the skull
    Young Tae Kim
    Department of Bioengineering, The Keck Center for Tissue Engineering, University of Utah, Salt Lake City, UT 84112, USA
    Biomaterials 25:2229-37. 2004
    ....
  86. ncbi Immune reactions associated with silicone-based ventriculo-peritoneal shunt malfunctions in children
    Pamela J VandeVord
    Departments of Pediatric Neurosurgery, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Biomaterials 25:3853-60. 2004
    ....
  87. ncbi Influence of particle size in the effect of polyethylene on human osteoblastic cells
    A M Rodrigo
    Investigation Unit, Hospital La Paz, Madrid, Spain
    Biomaterials 22:755-62. 2001
    ..We conclude that particle size affects the influence of polyethylene on osteoblastic function markers. Particles with a diameter of less than 30 microm increase osteocalcin expression and secretion...
  88. ncbi Effects of crosslinking degree of an acellular biological tissue on its tissue regeneration pattern
    Huang Chien Liang
    Department of Chemical Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan, ROC
    Biomaterials 25:3541-52. 2004
    ..In conclusion, the crosslinking degree determines the degradation rate of the acellular tissue and its tissue regeneration pattern...
  89. ncbi Difference in metallic wear distribution released from commercially pure titanium compared with stainless steel plates
    G D Krischak
    Department of Traumatology, Hand and Reconstructive Surgery, University of Ulm, Steinhovelstr 9, 89075, Ulm, Germany
    Arch Orthop Trauma Surg 124:104-13. 2004
    ..However, it is still being controversially discussed whether there are significant differences in tissue reaction and metallic release, which should result in a recommendation for preferred use in clinical practice...
  90. ncbi [Experimental study of biocompatibility of LIFEs in peripheral fascicles]
    Xiu jun Zheng
    Orthopedic Department, Zhong Shan Hospital Affiliated to FuDan University, Shanghai 200032, China
    Zhonghua Yi Xue Za Zhi 83:2152-7. 2003
    ..And to discuss the possibility of peripheral fascicular signals as a new signal source to control an electronic prosthetic hand...
  91. ncbi Impact of mesh positioning on foreign body reaction and collagenous ingrowth in a rabbit model of open incisional hernia repair
    M Binnebösel
    Department of Surgery, RWTH Aachen University Hospital, Aachen, Germany
    Hernia 14:71-7. 2010
    ..Different mesh techniques are used in 75-80% of hernia repair. The aim of this study was to evaluate the dependence of mesh positioning and the type of mesh implanted on foreign body reaction and collagenous ingrowth.
  92. ncbi Trevira mesh: a promising new implant for the treatment of abdominal hernias
    Jürgen Zieren
    Department of General, Visceral, Vascular and Thoracic Surgery, Charite, Campus Mitte, Humboldt University of Berlin, Schumannstrasse 20 21, 10117 Berlin, Germany
    Langenbecks Arch Surg 387:8-13. 2002
    ..terephthalate) has been in clinical use for more than 20 years, serving as implant material with minimal foreign body reaction for the replacement of the cruciate ligaments of the knee...
  93. ncbi The effect of capsule composition on the biocompatibility of alginate-poly-l-lysine capsules
    H A Clayton
    Department of Surgery, University of Leicester, Leicester Royal Infirmary, UK
    J Microencapsul 8:221-33. 1991
    ..there has been no published study concerning the effect of capsule composition on the severity of the foreign body reaction. Empty capsules were prepared from high mannuronic acid alginate and were coated with: (1) poly-l-lysine ..
  94. ncbi Foreign body reaction to hemostatic materials mimicking recurrent brain tumor. Report of three cases
    K F Kothbauer
    Department of Neurosurgery, Beth Israel Medical Center, New York, New York 10128, USA
    J Neurosurg 95:503-6. 2001
    Chemical agents routinely used in neurosurgery to achieve intraoperative hemostasis can cause a foreign body reaction, which appears on magnetic resonance (MR) images to be indistinguishable from recurrent tumor...
  95. ncbi Histological analysis of human diced cartilage grafts
    Jay W Calvert
    Veterans Affairs Hospital Long Beach, Department of Surgery and Research
    Plast Reconstr Surg 118:230-6. 2006
    ..This article investigates four means of radix and dorsum augmentation, including banked and fresh septum...
  96. ncbi Influence of mesh materials on the integrity of the vas deferens following Lichtenstein hernioplasty: an experimental model
    K Junge
    Department of Surgery, Technical University of Aachen, Pauwelsstr 30, 52074, Aachen, Germany
    Hernia 12:621-6. 2008
    ..The aim of this study was to evaluate the effect of different mesh structures on integrity of the vas deferens...
  97. ncbi Preserved costal cartilage homograft application for the treatment of temporomandibular joint ankylosis
    Z Demir
    Department of Plastic and Reconstructive Surgery, Social Security Organization Ankara Hospital, Ankara, Turkey
    Plast Reconstr Surg 108:44-51. 2001
    ..Our clinical experience over the past 4 years with the use of preserved homologous costal cartilage grafts as interpositional material has been encouraging...
  98. ncbi Meconium contaminated amniotic fluid and infant otitis media. Is it a risk factor in children surviving aspiration and initial distress of respiration?
    Markus Lilja
    Department of Otolaryngology, Helsinki University Central Hospital, Haartmaninkatu 4E, FIN 00290 Helsinki, Finland
    Int J Pediatr Otorhinolaryngol 70:655-62. 2006
    Histological studies show that amniotic fluid cellular content (AFCC) causes in the middle ear a foreign body reaction, the extent and severity of which depends upon the massiveness of contamination...
  99. ncbi Introduction of polyethylene terephthalate mesh (KoSa hochfest) for abdominal hernia repair: an animal experimental study
    Jürgen Zieren
    Department of General Surgery, Charite, Humboldt University Berlin, Germany
    Biomed Mater Eng 14:127-32. 2004
    ..In an animal trial it was therefore tested as mesh implant for hernia treatment and compared with Prolene...
  100. ncbi Intraabdominal adhesion formation of polypropylene mesh. Influence of coverage of omentum and polyglactin
    J Conze
    Department of Surgery, Rhenish Westphalian Technical University, Aachen, Germany
    Surg Endosc 19:798-803. 2005
    ..To investigate the adhesive potential induced by the biomaterial, an animal model was performed. In addition, the influence of coverage by omentum or a polyglactin barrier was investigated...
  101. ncbi Sinus floor augmentation with simultaneous placement of dental implants using a combination of deproteinized bone xenografts and recombinant human osteogenic protein-1. A histometric study in miniature pigs
    H Terheyden
    Dept of Oral and Maxillofacial Surgery, University of Kiel, Germany
    Clin Oral Implants Res 10:510-21. 1999
    ..is controversial, since their use can lead to a prolonged healing time, inhomogenous ossification, foreign body reaction, migration of particles and low bone-implant contact (BIC)...

Research Grants42

  1. FOREIGN BODY REACTION AND DEVICE CENTERED INFECTION
    Liping Tang; Fiscal Year: 2002
    ..abstract_text> ..
  2. Modulating and Monitoring the Foreign Body Response to Implants
    Julie A Stenken; Fiscal Year: 2013
    ..All implanted materials elicit an immune response that leads to the foreign body reaction. This foreign body reaction often causes fibrosis around the implant...
  3. Infection resistant surface for ventricular assist device (VAD) transcutaneous dr
    PATRICK THOMAS CAHALAN; Fiscal Year: 2013
    ..First, by breaching skin with transcutaneous cannulae and drivelines, and second, by eliciting a foreign body reaction which results in scarring near the implant surface that creates an environment where bacteria can thrive ..
  4. Passivating Proteins in Implantable Glucose Sensors
    W Ward; Fiscal Year: 2004
    ..The goal of this work is to develop coatings that will reduce the foreign body reaction to implanted glucose sensors, thereby extending their useful life...
  5. Human macrophage immunophenotype modulated by biomaterial-encapsulated MSC
    WEIYUAN J KAO; Fiscal Year: 2013
    ..properties, the impact of the MSC-encapsulated biomatrix on the host macrophage immunophenotype and host foreign body reaction is less clear...
  6. The Interplay between Macrophages and Differentiating MSCs in Cell-Laden Hydrogel
    Stephanie J Bryant; Fiscal Year: 2013
    ..provided by applicant): The overall goal of this proposal is to better understand the role of the foreign body reaction (FBR) in tissue engineering and in particular the dynamic interplay between interrogating macrophages and ..
  7. OXIDATIVE STRESS EFFECT ON DEGRADATION DEBRIS
    John Schmitz; Fiscal Year: 1999
    ..Clinically significant morbidity has been reported including an unpredictable foreign body reaction which has necessitated surgical exploration, debridement, and removal of the implants...
  8. Development of a Debridement Device Using Ice Particles
    LUIZ DA SILVA; Fiscal Year: 2001
    ..are unsuitable for use on bums or clean wounds because the particles can lead to granuloma formation or foreign body reaction. We propose to develop a novel MDA device that uses biocompatible ice particles to safely abrade tissue...
  9. OPTIMAL LASER FOR SMALL DIAMETER VASCULAR ANASTOMOSES
    Robert Kung; Fiscal Year: 1990
    ..have several advantages over manual suturing, some examples of which are shorter operative times, and less foreign body reaction at the anastomosis...
  10. AN OPTIMAL LASER FOR SMALL DIAMETER VASCULAR ANASTOMOSES
    Robert Kung; Fiscal Year: 1993
    ..have several advantages over manual suturing, some examples of which are shorter operative times, and less foreign body reaction at the anastomosis...
  11. MICROENCAPSULATED ISLET XENOGRAFTS IN NOD MICE
    Collin Weber; Fiscal Year: 1993
    ..e., the presence of a foreign body reaction limits the function of the graft...
  12. BIODEGRADABLE VASCULAR GRAFTS
    IH HOUNG LOH; Fiscal Year: 1993
    ..of biodegradable polymers for vascular reconstruction has two major advantages: the elimination of chronic foreign body reaction and the regeneration of arterial tissues including a nonthrombogenic pseudointima layer...
  13. Infusion of Particles at Implant interfeces
    Stuart Goodman; Fiscal Year: 2006
    ..abstract_text> ..
  14. Osteolysis and Implant Wear: Biological, Biomedical Engineering, and Surgical Pri
    Stuart Goodman; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  15. INTERFACE MECHANICS, MATERIALS AND TISSUE RESPONSE
    Joan Sanders; Fiscal Year: 2007
    ..The development of methods to predict and overcome the detrimental effects of residual limb shape change and ultimately prevent soft-tissue breakdown will help to prevent secondary disability and morbidity in the amputee population. ..
  16. Skin Adaptation to Mechanical Stress
    Joan Sanders; Fiscal Year: 2006
    ..By understanding the process of skin adaptation (natural skin strengthening) at both a cellular and molecular level, therapies to encourage skin adaptation before breakdown occurs can be intelligently pursued. ..
  17. Assessment of Tissue Response to Stress
    Joan Sanders; Fiscal Year: 2006
    ..this technology could be applied to other areas of rehabilitation, for example, shoe design for patients with insensate feet, cushion design for wheelchair users, and mattress design for bedridden patients [unreadable] [unreadable]..
  18. INTERFACE MECHANICS, MATERIALS, AND TISSUE RESPONSE
    Joan Sanders; Fiscal Year: 2003
    ....
  19. INTERFACE MECHANICS, MATERIALS, AND TISSUE RESPONSE
    Joan Sanders; Fiscal Year: 2002
    ....
  20. NEW BIOMATERIALS TO MINIMIZE SCAR TISSUE FORMATION
    Joan Sanders; Fiscal Year: 2002
    ..These are key indicators of implant integration or activation of the foreign body reaction. The significance of this research is to apply an innovative material and fabrication method to assess the ..
  21. BIOFUNCTIONAL MATERIALS CONTAINING PROTEIN MIMETICS
    WEIYUAN KAO; Fiscal Year: 2007
    ....
  22. Training in Engineered Biomaterials
    Buddy Ratner; Fiscal Year: 2007
    ..Trainees will participate in the training program for a period of 2 years. ..
  23. FOREIGN BODY REACTION AND DEVICE CENTERED INFECTION
    Liping Tang; Fiscal Year: 2001
    ..abstract_text> ..
  24. LYMPHOCYTE/MACROPHAGE INTERACTIONS ON BIOMATERIALS
    James Anderson; Fiscal Year: 2001
    ..characterization the potential functional significance of giant cells at sites of inflammation and foreign body reaction. Our experimental approach will utilize molecularly-engineered, micropatterned and temperature responsive ..
  25. Interaction between host cells and multicomponent material matrix
    WEIYUAN KAO; Fiscal Year: 2009
    ..e., human blood-derived macrophages, dermal fibroblasts, and keratinocytes) using monoculture and binary cell culture systems. (3) To ascertain IPN efficacy in vivo in modulating the host reaction and healing. ..
  26. Engineered Cardiac Morphogenesis-Stem Cells and Scaffolds
    Buddy D Ratner; Fiscal Year: 2010
    ..This comprehensive approach to heart muscle repair will be implemented by a collaborative, multidisciplinary team closely integrating engineers, scientists and clinicians. ..
  27. YOUTH TAKE HEART (PHASE I & II)
    Buddy Ratner; Fiscal Year: 2007
    ..Youth Take Heart will help enhance the cardiovascular health and quality of life for numerous students through the teaching of medical management, prevention, and control of risk factors for heart disease. ..
  28. BIOFUNCTIONAL MATERIALS CONTAINING PROTEIN MIMETICS
    WEIYUAN KAO; Fiscal Year: 2001
    ..macrophages (a class of phagocytic leukocytes) play a critical role in directing inflammation and foreign body reaction to biomaterials...
  29. BIOFUNCTIONAL MATERIALS CONTAINING PROTEIN MIMETICS
    WEIYUAN KAO; Fiscal Year: 2003
    ..macrophages (a class of phagocytic leukocytes) play a critical role in directing inflammation and foreign body reaction to biomaterials...
  30. BIOCOMPATIBILITY: SURFACE INITIATED BIOCHEMISTRY
    Liping Tang; Fiscal Year: 2007
    ..This knowledge will provide a starting point for the future design of surface tailored implantable materials having desired tissue reactivity and, as needed, wound healing response. ..
  31. 1st International Symposium on Wound Healing and Technology (WHAT I)
    Buddy Ratner; Fiscal Year: 2006
    ..Communication and discussion of these problems and new ideas for how we can address them are central to this meeting. [unreadable] [unreadable] [unreadable]..
  32. BIOMEDICAL POLYMERS--CELL ADHESION AND CYTOKINES
    James Anderson; Fiscal Year: 2006
    ..chemistry on major biological response mechanism, that represent multiple and interrelated aspects of the foreign body reaction. The specific aims of the project are: 1) To determine the mechanisms of monocyte/macrophage recruitment, ..
  33. INFECTION MECHANISMS WITH CARDIOVASCULAR PROSTHESES
    JAMES MORLEY ANDERSON; Fiscal Year: 2010
    ..A fibrinogen-based peptide sequence based on fibrinogen/Fbe (S. epidermidis) will be used as a blocking ligand to investigate adhesion blocking mechanisms to prevent bacterial aggregation and biofilm formation. ..
  34. INFECTION MECHANISMS WITH CARDIOVASCULAR PROSTHESES
    James Anderson; Fiscal Year: 2001
    ..The biomaterial infection model in rats will be used to test the validity of the in vitro models, as well as the efficacy of the biomimetic coatings ..
  35. PERITONEAL DELIVERY OF ANTINEOPLASTIC MACROMOLECULES
    MICHAEL FLESSNER; Fiscal Year: 2004
    ....
  36. SYSTEMIC IMPLICATIONS OF TOTAL JOINT REPLACEMENT
    Joshua Jacobs; Fiscal Year: 2009
    ..abstract_text> ..
  37. MICROELECTRODE ARRAYS FOR DEEP BRAIN STIMULATION AND REC
    Douglas McCreery; Fiscal Year: 2002
    ..We will attach multisite silicon substrate recording microelectrode arrays to some of the iridium shafts and these will be chronically implanted into the feline globus pallidus and subthalamic nuclei for up to 180 days. ..
  38. Effects of Hyaluronan on Interstitial Convection
    MICHAEL FLESSNER; Fiscal Year: 2007
    ..The results of this research project will provide a basis for future work designed to preserve or enhance the transport characteristics of peritoneal tissue during chronic dialysis. ..
  39. Arrays for deep brain microstimulation and recording
    DOUGLAS BUCHANAN MCCREERY; Fiscal Year: 2010
    ..This technology will improve quality of life for persons afflicted with Parkinson's Disease and other movement disorders. ..
  40. Assesment of a Chronic Subcutaneous Glucose Sensor
    W Ward; Fiscal Year: 2003
    ..ether-based polymer. We will compare their long term function in studies using rabbits, which will be also be used to ascertain the effect of the growth factors and the real-time data processing. ..
  41. Bioreactivity Markers in Total Hip Replacments
    Nadim Hallab; Fiscal Year: 2004
    ..Additionally, variable immunologic responses induced by implant degradation products (i.e. lymphocyte response to metal ions and monocyte/macrophage response to particulate debris) will be correlated with the development of osteolysis ..