burns

Summary

Summary: Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like.

Top Publications

  1. ncbi Potential of honey in the treatment of wounds and burns
    P C Molan
    Honey Research Unit, University of Waikato, Hamilton, New Zealand
    Am J Clin Dermatol 2:13-9. 2001
  2. doi American Burn Association practice guidelines burn shock resuscitation
    Tam N Pham
    University of Washington Burn Center, Seattle, Washington 98104, USA
    J Burn Care Res 29:257-66. 2008
  3. pmc Emerging infections in burns
    Ludwik K Branski
    Department of Surgery, The University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, Texas 77550, USA
    Surg Infect (Larchmt) 10:389-97. 2009
  4. doi Contribution of bacterial and viral infections to attributable mortality in patients with severe burns: an autopsy series
    Laurie C D'Avignon
    Infectious Disease Service, San Antonio Military Medical Center, Brooke Army Medical Center, 3851 Roger Brooke Drive, Fort Sam Houston, TX 78234, USA
    Burns 36:773-9. 2010
  5. pmc Burn-induced gut barrier injury is attenuated by phosphodiesterase inhibition: effects on tight junction structural proteins
    Todd W Costantini
    Division of Trauma, Surgical Critical Care, and Burns, Department of Surgery, University of California San Diego School of Medicine, San Diego, California, USA
    Shock 31:416-22. 2009
  6. pmc Chitosan preparations for wounds and burns: antimicrobial and wound-healing effects
    Tianhong Dai
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Expert Rev Anti Infect Ther 9:857-79. 2011
  7. doi Propolis and amnion reepithelialise second-degree burns in rats
    Alicia Greyce Turatti Pessolato
    Faculty of Veterinary Medicine and Animal Science, Department of Surgery, University of Sao Paulo, São Paulo 05508 270, Sao Paulo, Brazil
    Burns 37:1192-201. 2011
  8. ncbi Serum cytokine differences in severely burned children with and without sepsis
    Celeste C Finnerty
    Shriners Hospitals for Children, Galveston, TX 77550, USA
    Shock 27:4-9. 2007
  9. doi Epidemiology of burns in Iran during the last decade (2000-2010): review of literature and methodological considerations
    Homayoun Sadeghi-bazargani
    Injury Epidemiology and Prevention Research Center, Statistics and Epidemiology Department, School of Health and Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran
    Burns 38:319-29. 2012
  10. pmc Pathophysiologic response to severe burn injury
    Marc G Jeschke
    Shriners Hospitals for Children, University Texas Medical Branch, Galveston, Texas 77550, USA
    Ann Surg 248:387-401. 2008

Detail Information

Publications451 found, 100 shown here

  1. ncbi Potential of honey in the treatment of wounds and burns
    P C Molan
    Honey Research Unit, University of Waikato, Hamilton, New Zealand
    Am J Clin Dermatol 2:13-9. 2001
    ..in recent times in the use of honey, an ancient and traditional wound dressing, for the treatment of wounds, burns, and skin ulcers...
  2. doi American Burn Association practice guidelines burn shock resuscitation
    Tam N Pham
    University of Washington Burn Center, Seattle, Washington 98104, USA
    J Burn Care Res 29:257-66. 2008
  3. pmc Emerging infections in burns
    Ludwik K Branski
    Department of Surgery, The University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, Texas 77550, USA
    Surg Infect (Larchmt) 10:389-97. 2009
    Patients who suffer severe burns are at higher risk for local and systemic infections. In recent years, emerging resistant pathogens have forced burn care providers world wide to search for alternative forms of treatment...
  4. doi Contribution of bacterial and viral infections to attributable mortality in patients with severe burns: an autopsy series
    Laurie C D'Avignon
    Infectious Disease Service, San Antonio Military Medical Center, Brooke Army Medical Center, 3851 Roger Brooke Drive, Fort Sam Houston, TX 78234, USA
    Burns 36:773-9. 2010
    ..This study is a retrospective review of all autopsy reports from patients with severe thermal burns treated at the US Army Institute of Research (USAISR) burn unit over 12 years...
  5. pmc Burn-induced gut barrier injury is attenuated by phosphodiesterase inhibition: effects on tight junction structural proteins
    Todd W Costantini
    Division of Trauma, Surgical Critical Care, and Burns, Department of Surgery, University of California San Diego School of Medicine, San Diego, California, USA
    Shock 31:416-22. 2009
    ..Therefore, phosphodiesterase inhibition may be a useful adjunct strategy in the attenuation of burn-induced gut barrier injury...
  6. pmc Chitosan preparations for wounds and burns: antimicrobial and wound-healing effects
    Tianhong Dai
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Expert Rev Anti Infect Ther 9:857-79. 2011
    ..Studies covering applications of chitosan in wounds and burns can be classified into in vitro, animal and clinical studies...
  7. doi Propolis and amnion reepithelialise second-degree burns in rats
    Alicia Greyce Turatti Pessolato
    Faculty of Veterinary Medicine and Animal Science, Department of Surgery, University of Sao Paulo, São Paulo 05508 270, Sao Paulo, Brazil
    Burns 37:1192-201. 2011
    b>Burns are serious consequences of trauma in terms of both imminent mortality and prolonged periods of morbidity. They are often accompanied by unsatisfactory cosmetic as well as functional and psychological outcomes...
  8. ncbi Serum cytokine differences in severely burned children with and without sepsis
    Celeste C Finnerty
    Shriners Hospitals for Children, Galveston, TX 77550, USA
    Shock 27:4-9. 2007
    ..In addition, serum IL-6, IL-12 p70, and TNF can be used to identify burned patients who are at high risk of death from sepsis...
  9. doi Epidemiology of burns in Iran during the last decade (2000-2010): review of literature and methodological considerations
    Homayoun Sadeghi-bazargani
    Injury Epidemiology and Prevention Research Center, Statistics and Epidemiology Department, School of Health and Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran
    Burns 38:319-29. 2012
    ..prevention, to be effective in a particular area, should be based on sound knowledge of etiological patterns of burns injuries and must take into account the geographical variations and socioeconomic differences in burn epidemiology...
  10. pmc Pathophysiologic response to severe burn injury
    Marc G Jeschke
    Shriners Hospitals for Children, University Texas Medical Branch, Galveston, Texas 77550, USA
    Ann Surg 248:387-401. 2008
    ..To improve clinical outcome and to determine new treatment options, we studied the pathophysiologic response postburn in a large prospective, single center, clinical trial...
  11. doi Time course of pro- and anti-inflammatory cytokine levels in patients with burns--prognostic value of interleukin-10
    C Csontos
    Department of Anaesthesia and Intensive Care, Faculty of Medicine, University of Pecs, Akác u 1, Pécs 7632, Hungary
    Burns 36:483-94. 2010
    Trends and the prognostic value of cytokine responses to severe burns have not been fully examined in humans...
  12. pmc Severe injury is associated with insulin resistance, endoplasmic reticulum stress response, and unfolded protein response
    Marc G Jeschke
    Ross Tilley Burn Centre, Sunnybrook Health Science Centre, Department of Surgery, Sunnybrook Research Institute, University of Toronto, Ontario, Canada
    Ann Surg 255:370-8. 2012
    ..We determined whether postburn hyperglycemia and insulin resistance are associated with endoplasmic reticulum (ER) stress/unfolded protein response (UPR) activation leading to impaired insulin receptor signaling...
  13. doi Common pathogens in burn wound and changes in their drug sensitivity
    Ezzatollah Rezaei
    Department of Plastic Surgery, Mashhad University of Medical Sciences, Mashhad, Iran
    Burns 37:805-7. 2011
    Infection is an important cause of mortality in patients with burns. Rapid emergence of hospital pathogens and antibiotic-resistant organisms necessitate periodic evaluation of bacterial colonisation patterns and antibiogram sensitivity ..
  14. doi Burn care costing: the Welsh experience
    Sarah J Hemington-Gorse
    Welsh Centre for Burns and Plastic Surgery, Morriston Hospital, Morriston, Swansea, United Kingdom
    Burns 35:378-82. 2009
    ..There is, however, little published data to show how "expensive" it is. At the Welsh Centre for burns we have undertaken a costing exercise in an attempt to define the true cost to the treatment of burns...
  15. doi Targeting α-7 nicotinic acetylcholine receptor in the enteric nervous system: a cholinergic agonist prevents gut barrier failure after severe burn injury
    Todd W Costantini
    Division of Trauma, Surgical Critical Care, and Burns, Department of Surgery, University of California San Diego Health Sciences, San Diego, California, USA
    Am J Pathol 181:478-86. 2012
    ....
  16. doi Hyaluronic acid derivatives and their healing effect on burns, epithelial surgical wounds, and chronic wounds: a systematic review and meta-analysis of randomized controlled trials
    Jeffrey Voigt
    Medical Device Consultants of Ridgewood, LLC, 99 Glenwood Road, Ridgewood, NJ 07450, USA
    Wound Repair Regen 20:317-31. 2012
    ..was performed to identify randomized controlled trials, evaluating the use of HA derivatives in healing burns, epithelial surgical, and chronic wounds...
  17. pmc Effect of ablated bronchial blood flow on survival rate and pulmonary function after burn and smoke inhalation in sheep
    Atsumori Hamahata
    Department of Plastic and Reconstructive Surgery, Tokyo Women s Medical University, Tokyo, Japan
    Burns 35:802-10. 2009
    ..Ablated bronchial circulation attenuated these pathophysiological changes...
  18. doi Ulinastatin improves pulmonary function in severe burn-induced acute lung injury by attenuating inflammatory response
    Yong Fang
    Department of Burns and Plastic Surgery, No 3 People s Hospital, Shanghai, People s Republic of China
    J Trauma 71:1297-304. 2011
    ..Ulinastatin is potentially an effective intervention, because it attenuates the systemic inflammatory response induced by endotoxin and improves myocardial function during ischemic shock and reperfusion...
  19. doi High-frequency percussive ventilation and low tidal volume ventilation in burns: a randomized controlled trial
    Kevin K Chung
    U S Army Institute of Surgical Research, Fort Sam Houston, TX, USA
    Crit Care Med 38:1970-7. 2010
    ..The purpose of this study was to prospectively compare the two ventilator modalities in a burn intensive care unit setting...
  20. ncbi A review of the local pathophysiologic bases of burn wound progression
    Jeffrey W Shupp
    The Burn Center, Department of Surgery, Washington Hospital Center, Washington, DC, USA
    J Burn Care Res 31:849-73. 2010
    ....
  21. pmc Temporal cytokine profiles in severely burned patients: a comparison of adults and children
    Celeste C Finnerty
    Shriners Hospitals for Children, 815 Market Street, Galveston, TX 77550, USA
    Mol Med 14:553-60. 2008
    ..Following severe flame burns, the cytokine profiles in pediatric patients differ compared with those in adult patients, which may provide ..
  22. ncbi Hyperalgesia in a human model of acute inflammatory pain: a methodological study
    J L Pedersen
    Department of Surgical Gastroenterology, Hvidovre University Hospital, Denmark
    Pain 74:139-51. 1998
    ..Mild burns were produced on the crura of 12 volunteers with a 50 x 25 mm thermode (47 degrees C, 7 min)...
  23. pmc Burn-induced acute lung injury requires a functional Toll-like receptor 4
    Michael Krzyzaniak
    Division of Trauma, Surgical Critical Care, and Burns, Department of Surgery, University of California, San Diego School of Medicine, San Diego, California, USA
    Shock 36:24-9. 2011
    ..Toll-like receptor 4 KO animals were clearly protected and had a much less severe lung injury. Our data suggest that burn-induced ALI is a TLR4-dependent process...
  24. doi Stem cells and burns: review and therapeutic implications
    Kathryn L Butler
    Sumner Redstone Burn Center at Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Burn Care Res 31:874-81. 2010
    ..Through a review of the literature, this article seeks to illustrate applications of stem cell therapy to burn care and to highlight promising areas of research...
  25. doi The risks of using samovars as the main tea-preparing facility in some Eastern countries
    Homayoun Sadeghi-bazargani
    Karolinska Institute, Stockholm, Sweden
    Burns 34:1149-52. 2008
    ..In part of a joint Iran-Sweden research project on epidemiology and prevention of burns, 265 households in a rural area were entered into a cross-sectional study in which safety status of samovars used ..
  26. pmc Unintentional childhood injury patterns, odds, and outcomes in Kampala City: an analysis of surveillance data from the National Pediatric Emergency Unit
    Milton Mutto
    Pincer Group International Ltd, Karolinska Institutet, Department of Public Health Sciences, Social Medicine, Sweden
    J Inj Violence Res 3:13-8. 2011
    ..We set to determine unintentional childhood injury pattern, odds, and outcomes at the National Paediatric Emergency unit in Kampala city using surveillance data...
  27. doi Predicting prognosis in thermal burns with associated inhalational injury: a systematic review of prognostic factors in adult burn victims
    Shannon M Colohan
    Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada
    J Burn Care Res 31:529-39. 2010
    ..An electronic search of English-language publications that identify prognostic risk factors in thermal burns including IHT was carried out...
  28. ncbi Suicide by self-immolation: comprehensive overview, experiences and suggestions
    Alireza Ahmadi
    Kermanshah University of Medical Sciences, Kermanshah City, Kermanshah Province, Iran
    J Burn Care Res 28:30-41. 2007
    ..The public health approach provides a framework for a National Prevention Strategy to address this serious national problem. Local data on victims and victim stories from self-immolation provided the stimulus for community action...
  29. pmc Long-term persistance of the pathophysiologic response to severe burn injury
    Marc G Jeschke
    Shriners Hospitals for Children, University of Texas Medical Branch, Galveston, Texas, United States of America
    PLoS ONE 6:e21245. 2011
    ....
  30. pmc Hypertrophic scar formation following burns and trauma: new approaches to treatment
    Shahram Aarabi
    Department of Surgery, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS Med 4:e234. 2007
  31. ncbi A prospective study of infections in burn patients
    Pia Appelgren
    Department of Infectious Diseases, Karolinska Hospital, SE 171 76, Stockholm, Sweden
    Burns 28:39-46. 2002
    In a 3-year prospective study, all infections presenting in the burns unit of a university hospital were registered in a specially designed database. Two-hundred and thirty adult patients were included...
  32. ncbi Effect of silver on burn wound infection control and healing: review of the literature
    Bishara S Atiyeh
    Division Plastic and Reconstructive Surgery, American University of Beirut Medical Center, Beirut, Lebanon
    Burns 33:139-48. 2007
    ..At present, silver is reemerging as a viable treatment option for infections encountered in burns, open wounds, and chronic ulcers...
  33. ncbi An audit of the use of laser Doppler imaging (LDI) in the assessment of burns of intermediate depth
    S A Pape
    Royal Victoria Infirmary, NE1 4LP, Newcastle upon Tyne, UK
    Burns 27:233-9. 2001
    ..It is based on a 6-month, prospective audit of 76 burns of intermediate depth. Clinical and LDI assessments of burn wound depth were recorded at 48-72 h post-injury...
  34. ncbi Elevated monocyte chemoattractant protein-1 levels following thermal injury precede monocyte recruitment to the wound site and are controlled, in part, by tumor necrosis factor-alpha
    Scott A Heinrich
    Department of Cell Biology, Neurobiology and Anatomy and Burn and Shock Trauma Institute, Loyola University Medical Center, Maywood, Illinois 60153, USA
    Wound Repair Regen 11:110-9. 2003
    ..01); however, macrophage accumulation was not altered. Thus, elevated systemic TNF-alpha levels may influence the local chemokine milieu following burn injury...
  35. doi Emerging therapy for improving wound repair of severe radiation burns using local bone marrow-derived stem cell administrations
    Eric Bey
    hôpital d instruction des armées Percy, Service de Chirurgie Plastique, BP 410, 92141 Clamart Cedex, France
    Wound Repair Regen 18:50-8. 2010
    The therapeutic management of severe radiation burns remains a challenging issue today...
  36. ncbi Heritability of responses to painful stimuli in women: a classical twin study
    Timothy A Norbury
    London Pain Consortium, King s College London, Neurorestoration, Wolfson CARD, Wolfson Wing, London Bridge, London, UK
    Brain 130:3041-9. 2007
    ..Since experimental pain sensitivity is known to be a predictor for pathological pain, our data imply that genetic factors have an important aetiological contribution towards clinical pain states...
  37. ncbi Significance of beta-radiation skin burns in Chernobyl patients for the theory and practice of radiopathology
    Anzhelika V Barabanova
    Ministry of Health, Clinical Department of the Institute of Biophysics, Moscow, Russia
    Vojnosanit Pregl 63:477-80. 2006
    ..The author of the article worked as a chief of surgical team responsible for the radiation burns treatment.
  38. ncbi Impact of a bicarbonated saline solution on early resuscitation after major burns
    M M Berger
    Soins intensifs de chirurgie, CHUV, Lausanne, Switzerland
    Intensive Care Med 26:1382-5. 2000
    ..The study aimed at assessing the impact of the introduction of a bicarbonated saline solution on total fluid load, weight gain and acid base status during acute burn resuscitation...
  39. doi Characterization and evaluation of silver release from four different dressings used in burns care
    Chiara Rigo
    University Ca Foscari of Venice, Department of Environmental Sciences, Statistics and Informatics, Dorsoduro 2137, 30123 Venice, Italy
    Burns 38:1131-42. 2012
    ..For centuries silver and silver compounds have been in use to control infection and avoid septicaemia in the care of burns and chronic wounds...
  40. doi Assessment of burn depth and burn wound healing potential
    Stan Monstrey
    Department of Plastic Surgery, Gent University Hospital, De Pintelaan 185, Gent, Belgium
    Burns 34:761-9. 2008
    ..Traditionally, burn surgeons divide burns into superficial which heal by rapid re-epithelialization with minimal scarring and deep burns requiring surgical ..
  41. pmc Risk and protective factors for fires, burns, and carbon monoxide poisoning in U.S. households
    Carol W Runyan
    Injury Prevention Research Center, University of North Carolina, Chapel Hill, North Carolina, USA
    Am J Prev Med 28:102-8. 2005
    More needs to be known about the prevalence of risk and protective factors for fires, burns, and carbon monoxide poisoning in U.S. households.
  42. pmc Alternative erythropoietin-mediated signaling prevents secondary microvascular thrombosis and inflammation within cutaneous burns
    Stefan Bohr
    Center for Engineering in Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 110:3513-8. 2013
    ..bind the erythropoietic EPO receptor homodimer, on the progression of secondary tissue damage following cutaneous burns. For this purpose, a deep partial thickness cutaneous burn injury was applied on the back of mice, followed by ..
  43. pmc Myosin light chain kinase mediates intestinal barrier disruption following burn injury
    Chuanli Chen
    State Key Laboratory of Trauma, Burns, and Combined Injury, Institute of Burn Research, Third Military Medical University, Southwest Hospital, Chongqing, China
    PLoS ONE 7:e34946. 2012
    ..We hypothesized that the MLCK-dependent MLC phosphorylation mediates the regulation of intestinal barrier function following burn injury, and that MLCK inhibition attenuates the burn-induced intestinal barrier disfunction...
  44. ncbi Base deficit and lactate: early predictors of morbidity and mortality in patients with burns
    D Andel
    Department of Anesthesia and Intensive Care, Medical University Vienna, Vienna, Austria
    Burns 33:973-8. 2007
    ....
  45. doi Relationship between high-mobility group box 1 protein release and T-cell suppression in rats after thermal injury
    Li Tian Zhang
    Department of Microbiology and Immunology, Burns Institute, First Hospital Affiliated to the Chinese PLA General Hospital, Beijing, People s Republic of China
    Shock 30:449-55. 2008
    ..High-mobility group box 1 protein released after major burns might be associated with the pathogenesis of immunosuppression in splenic T lymphocytes in rats.
  46. ncbi Myosin light chain phosphorylation and pulmonary endothelial cell hyperpermeability in burns
    John H Tinsley
    Dept of Medical Physiology, Texas A and M Univ System Health Science Center, 702 SW HK Dodgen Loop, Temple, TX 76504, USA
    Am J Physiol Lung Cell Mol Physiol 286:L841-7. 2004
    Major cutaneous burns result in not only localized tissue damage but broad systemic inflammation causing organ system damage distal to the burn site...
  47. pmc Burns: where are we standing with propranolol, oxandrolone, recombinant human growth hormone, and the new incretin analogs?
    Gerd G Gauglitz
    Department of Dermatology and Allergy, Ludwig Maximilian University, Munich, Germany
    Curr Opin Clin Nutr Metab Care 14:176-81. 2011
    ..This review focuses on the more recent advances in therapeutic strategies to attenuate the hypermetabolic response and its associated insulin resistance postburn...
  48. doi Blood levels, apoptosis, and homing of the endothelial progenitor cells after skin burns and escharectomy
    Carlo Foresta
    Department of Histology, Microbiology, and Medical Biotechnologies, Center for Male Gamete Cryopreservation, Section of Clinical Pathology, Clinic of Plastic and Reconstructive Surgery, University of Padova, Padova, Italy
    J Trauma 70:459-65. 2011
    Skin burns are an acute trauma involving an extensive vascular damage and an intense inflammatory response...
  49. pmc A randomized, controlled trial of immersive virtual reality analgesia, during physical therapy for pediatric burns
    Yuko S Schmitt
    Department of Anesthesiology, University of Washington, Seattle, WA, USA
    Burns 37:61-8. 2011
    ..The magnitude of the analgesic effect is clinically meaningful and is maintained with repeated use...
  50. doi Acticoat dressings and major burns: systemic silver absorption
    Naiem S Moiemen
    The Midlands Burn Centre, University Hospitals Birmingham Foundation Trust, UK
    Burns 37:27-35. 2011
    ..An earlier study of Acticoat use in small burns showed transient elevations of serum silver...
  51. pmc Children with burn injuries--assessment of trauma, neglect, violence and abuse
    Michael H Toon
    Critical Care Research Group and The University of Queensland, The Prince Charles Hospital at Brisbane, Australia
    J Inj Violence Res 3:98-110. 2011
    b>Burns are an important cause of injury to young children, being the third most frequent cause of injury resulting in death behind motor vehicle accidents and drowning...
  52. doi Cell therapy of burns
    T Leclerc
    Burn Treatment Center, Percy Military Hospital, Clamart, France
    Cell Prolif 44:48-54. 2011
    Severe burns remain a life-threatening local and general inflammatory condition often with serious sequelae, despite remarkable progress in their treatment over the past three decades...
  53. pmc In situ metabolic flux analysis to quantify the liver metabolic response to experimental burn injury
    Maria Louisa Izamis
    The Center for Engineering in Medicine, Massachusetts General Hospital Harvard Medical School Shriners Hospitals for Children, Boston, Massachusetts 02114, USA
    Biotechnol Bioeng 108:839-52. 2011
    Trauma such as burns induces a hypermetabolic response associated with altered central carbon and nitrogen metabolism...
  54. doi Hydrogen-rich saline protects against acute lung injury induced by extensive burn in rat model
    Yong Fang
    Department of Burns and Plastic Surgery, Number 3 People s Hospital, Institute of Traumatic Medicine, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    J Burn Care Res 32:e82-91. 2011
    ..The lungs were harvested 12 hours postburn for laboratory investigations. Severe burns with delayed resuscitation rapidly caused lung edema and impaired oxygenation in rats...
  55. doi Burns, biofilm and a new appraisal of burn wound sepsis
    Peter Kennedy
    Burns Unit, Concord Hospital, Hospital Road Concord, Sydney, NSW 2139, Australia
    Burns 36:49-56. 2010
    ..Biofilms are associated with development of antibiotic resistant organisms and are refractory to the immune system. The presence of biofilm in the burn wound has not been documented...
  56. pmc Efferent vagal nerve stimulation attenuates gut barrier injury after burn: modulation of intestinal occludin expression
    Todd W Costantini
    Division of Trauma, Surgical Critical Care, and Burns, Department of Surgery, University of California San Diego School of Medicine, San Diego, California, USA
    J Trauma 68:1349-54; discussion 1354-6. 2010
    ....
  57. doi Garlic ointment inhibits biofilm formation by bacterial pathogens from burn wounds
    Pushpalatha Nidadavolu
    Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock, TX, USA
    J Med Microbiol 61:662-71. 2012
    ..Thus, GarO could be used as a prophylactic therapy to prevent wound biofilms caused by both Gram-negative and Gram-positive bacteria from forming, and may be a potential therapy for disrupting established staphylococcal biofilms...
  58. pmc Nebulization with γ-tocopherol ameliorates acute lung injury after burn and smoke inhalation in the ovine model
    Yusuke Yamamoto
    Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Shock 37:408-14. 2012
    ..Delivery of g-T into the lungs may be a safe, novel, and efficient approach for management of acute lung injury patients who have sustained oxidative damage to the airway...
  59. doi Epidemiology of burns throughout the World. Part II: intentional burns in adults
    Michael D Peck
    Arizona Burn Center, Phoenix, AZ, United States
    Burns 38:630-7. 2012
    A significant number of burns and deaths from fire are intentionally wrought...
  60. doi Effectiveness of laser photobiomodulation at 660 or 780 nanometers on the repair of third-degree burns in diabetic rats
    Gyselle C S Meireles
    Laser Center, School of Dentistry, Department of Propedeutics and Integrated Clinics, Universidade Federal da Bahia, Salvador, Brazil
    Photomed Laser Surg 26:47-54. 2008
    The aim of this investigation was to compare by light microscopy the effects of laser photobiomodulation (LPBM) at lambda = 660 nm and lambda = 780 nm on third-degree burns in diabetic Wistar rats.
  61. doi Critical care of the burn patient: the first 48 hours
    Barbara A Latenser
    Carver College of Medicine, University of Iowa Hospitals and Clinics, Department of Surgery, Iowa City, Iowa, USA
    Crit Care Med 37:2819-26. 2009
    ..The goal of this concise review is to provide an overview of some of the most important resuscitation and monitoring issues and approaches that are unique to burn patients compared with the general intensive care unit population...
  62. pmc Resolvin D2 restores neutrophil directionality and improves survival after burns
    Tomohiro Kurihara
    Shriners Hospital for Children, Boston, Massachuestts, USA
    FASEB J 27:2270-81. 2013
    Following severe burns and trauma injuries, the changes of neutrophil migratory phenotype are a double-edged sword...
  63. ncbi Methylprednisolone and ketorolac rapidly reduce hyperalgesia around a skin burn injury and increase pressure pain thresholds
    A Stubhaug
    University of Oslo, Faculty Division Rikshospitalet, Department of Anaesthesiology, Rikshospitalet Medical Centre, Oslo, Norway
    Acta Anaesthesiol Scand 51:1138-46. 2007
    ..The objectives of this study were to investigate the effects of methylprednisolone and ketorolac on hyperalgesia around a skin burn injury and on pressure pain thresholds...
  64. doi A novel TGF-beta antagonist speeds reepithelialization and reduces scarring of partial thickness porcine burns
    Adam J Singer
    Department of Emergency Medicine and the Division of Laboratory Animal Research, Stony Brook University, New York, USA
    J Burn Care Res 30:329-34. 2009
    ..that a novel TGF-beta peptantagonist would reduce scar formation and wound contraction in partial thickness burns by using a randomized controlled experiment. The subjects include two domestic pigs (20-25 kg)...
  65. doi Changes in bacterial isolates from burn wounds and their antibiograms: a 20-year study (1986-2005)
    Merlin Guggenheim
    Division of Hand, Plastic and Reconstructive Surgery, University Hospital Zurich, Zurich, Switzerland
    Burns 35:553-60. 2009
    ..Our aim is to elucidate shifts in the bacterial spectrum colonising burn wounds and corresponding antibiotic susceptibilities during a 20-year study period...
  66. ncbi Microbiologic aspects of predominant bacteria isolated from the burn patients in Korea
    W Song
    Department of Clinical Pathology, Hallym University College of Medicine, 948 1, Daelim dong, Youngdeungpo ku, 150 071, Seoul, South Korea
    Burns 27:136-9. 2001
    The risk of infection in burns is well-known. In recent decades, the antimicrobial resistance of bacteria isolated from burn patients has increased...
  67. pmc Early enteral nutrition in burns: compliance with guidelines and associated outcomes in a multicenter study
    Michael J Mosier
    Department of Surgery, Loyola University Medical Center, Maywood, Illinois 60153, USA
    J Burn Care Res 32:104-9. 2011
    ..advocate that initiation of EN by 24 hours be used as a formal recommendation in nutrition guidelines for severe burns, and that nutrition guidelines be actively disseminated to individual burn centers to permit a change in practice.
  68. doi Madecassoside isolated from Centella asiatica herbs facilitates burn wound healing in mice
    Mei Liu
    Department of Pharmacology of China Materia Medica, China Pharmaceutical University, Nanjing, People s Republic of China
    Planta Med 74:809-15. 2008
    ..Moreover, the results from the present study indicate that the effect of madecassoside on wound healing may involve several mechanisms including antioxidative activity, collagen synthesis and angiogenesis...
  69. doi Lactosyl derivatives function in a rat model of severe burn shock by acting as antagonists against CD11b of integrin on leukocytes
    Zhihui Zhao
    Jiangsu Province Key Laboratory for Molecular and Medical Biotechnology, Nanjing Normal University, China
    Glycoconj J 26:173-88. 2009
    ..The results suggest that both An-2 and Gu-4 significantly inhibit the adhesion of leukocytes to endothelial cells by binding to CD11b and thereby exert protective effects on severe burn shock...
  70. doi Prevalence and co-morbidity of psychiatric disorders 1-4 years after burn
    Mario H Ter Smitten
    Association of Dutch Burn Centres, Beverwijk, The Netherlands
    Burns 37:753-61. 2011
    ..We examined the prevalence of DSM-IV Axis I disorders in burn patients 1-4 years after burn, using a standardized structured clinical interview and comparing findings with a representative general population sample...
  71. pmc Early acute kidney injury predicts progressive renal dysfunction and higher mortality in severely burned adults
    Michael J Mosier
    University of Washington Burn Center at Harborview Medical Center, Seattle, WA 98104, USA
    J Burn Care Res 31:83-92. 2010
    ..Early AKI was associated with early multiple organ dysfunction and higher mortality risk. Better understanding of how early AKI develops and which patients are at risk for progressive renal dysfunction may lead to improved outcomes...
  72. pmc α-Tocopherol adipose tissue stores are depleted after burn injury in pediatric patients
    Maret G Traber
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Am J Clin Nutr 92:1378-84. 2010
    ..Adipose tissue α-tocopherol concentrations are generally accepted to reflect long-term vitamin E status...
  73. doi Topical silicone gel versus placebo in promoting the maturation of burn scars: a randomized controlled trial
    Martijn B A van der Wal
    Burn Center and the Department of Plastic, Reconstructive, and Hand Surgery, Red Cross Hospital, Beverwijk, The Netherlands
    Plast Reconstr Surg 126:524-31. 2010
    ..The objective of this study was to investigate the effectiveness of topical silicone gel in promoting the maturation of burn scars...
  74. pmc Role of p38 MAPK in burn-induced intestinal barrier breakdown
    Todd W Costantini
    Division of Trauma, Surgical Critical Care, and Burns, Department of Surgery, University of California San Diego School of Medicine, San Diego, CA 92103 8896, USA
    J Surg Res 156:64-9. 2009
    ....
  75. doi Saving the zone of stasis in burns with activated protein C: an experimental study in rats
    Mustafa Nisanci
    Department of Plastic and Reconstructive Surgery and Burn Center, Gulhane Military Medical Academy and Medical School, 06018 Etlik, Ankara, Turkey
    Burns 36:397-402. 2010
    ..The dual effect of APC, each of which has been shown to be favourable in saving the zone of stasis, may make this agent effective with a single effect in treatment of burn injury...
  76. doi Use of Acticoat dressings in burns: what is the evidence?
    Roba Khundkar
    Department of Plastic and Reconstructive Surgery, John Radcliffe Hospital, Headington, Oxford OX39DU, UK
    Burns 36:751-8. 2010
    ..Its ease of application and low frequency of change makes it an ideal dressing in burn wounds. More well designed and properly reported randomised controlled trials are essential for informed clinical decision-making...
  77. pmc Pathway analysis of liver metabolism under stressed condition
    Mehmet A Orman
    Department of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    J Theor Biol 272:131-40. 2011
    ..Pathway analysis was also used to identify the main sources for the production of certain products in the hepatic metabolic network to gain a better understanding of the effects of burn injury on liver metabolism...
  78. pmc Pathogenic role of macrophages in intradermal infection of methicillin-resistant Staphylococcus aureus in thermally injured mice
    Akira Asai
    The University of Texas Medical Branch, Department of Internal Medicine, Galveston, TX 77555 0435, USA
    Infect Immun 78:4311-9. 2010
    ..M2Mφ have been described as inhibitor cells for Mφ conversion from resident Mφ to M1Mφ...
  79. pmc Severe burn injury in Europe: a systematic review of the incidence, etiology, morbidity, and mortality
    Nele Brusselaers
    Department of General Internal Medicine, Infectious Diseases and Psychosomatic Medicine, Ghent University Hospital, De Pintelaan 185, Ghent 9000, Belgium
    Crit Care 14:R188. 2010
    ..The aim of this study was to describe the European hospitalized population with severe burn injury, including the incidence, etiology, risk factors, mortality, and causes of death...
  80. pmc Psychiatric morbidity and functional impairments in survivors of burns, traumatic injuries, and ICU stays for other critical illnesses: a review of the literature
    Dimitry S Davydow
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Int Rev Psychiatry 21:531-8. 2009
    Severe burns, traumatic injuries and other critical illnesses are a substantial source of morbidity in the United States...
  81. ncbi Infections in a burn intensive care unit: experience of seven years
    S G Santucci
    Nosocomial Infection Control Department, Hospital das Clinicas, Brazil
    J Hosp Infect 53:6-13. 2003
    The objective of this study is to describe infections in a specialized burns intensive care unit from 1993 to 1999...
  82. ncbi The effects of silver dressings on chronic and burns wound healing
    Chris Elliott
    Queen Alexandra s Royal Army Nursing Corps
    Br J Nurs 19:S32-6. 2010
    ..contained in dressings, while investigating the efficacy of silver-impregnated dressings in the management of burns and chronic wounds...
  83. pmc Pentoxifylline modulates intestinal tight junction signaling after burn injury: effects on myosin light chain kinase
    Todd W Costantini
    Department of Surgery, Division of Trauma, Surgical Critical Care, and Burns, University of California, San Diego School of Medicine, San Diego, California 92103 8896, USA
    J Trauma 66:17-24; discussion 24-5. 2009
    ..Therefore, we postulate that PTX will attenuate activation of the tight junction protein MLCK, which may decrease intestinal tight junction permeability after severe burn...
  84. doi Safety preparedness of urban community for New Year fireworks in Tehran
    Soheil Saadat
    Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran
    Burns 35:719-22. 2009
    ..Restriction of the use of fireworks and banning firecrackers lacking appropriate insertions on safety instructions are other solutions to be considered...
  85. pmc Comparison between civilian burns and combat burns from Operation Iraqi Freedom and Operation Enduring Freedom
    Steven E Wolf
    Burn Center, United States Army Institute of Surgical Research, 3400 Rawley E Chambers, Fort Sam Houston, TX 79234, USA
    Ann Surg 243:786-92; discussion 792-5. 2006
    ..To assess outcome differences between locally burned civilians and military personnel burned in a distant combat zone treated in the same facility...
  86. pmc Dendritic cell modification of neutrophil responses to infection after burn injury
    Julia Bohannon
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555 0591, USA
    J Immunol 185:2847-53. 2010
    ..The results of this study provide new insight into immunological mechanisms that can offer protection against infection after burn injury...
  87. ncbi Early excision and grafting of face and neck burns in patients over 20 years
    Jana K Cole
    Harborview Medical Center Burn Center, Department of Surgery, Division of Plastic Surgery, University of Washington, Seattle 98104, USA
    Plast Reconstr Surg 109:1266-73. 2002
    Although excision and grafting of burns has become common and standard, many surgeons have been reluctant to excise and graft face burns...
  88. ncbi The use of Hyalomatrix PA in the treatment of deep partial-thickness burns
    Gianpiero Gravante
    Department of Surgery, University of Rome Tor Vergata, Italy
    J Burn Care Res 28:269-74. 2007
    ..used in our center on pediatric burned patients as a temporary dermal substitute to cover deep partial-thickness burns after dermabrasion...
  89. doi Epidemiology of minor and moderate burns in rural Ardabil, Iran
    Homayoun Sadeghi-bazargani
    RDCC and Soc Med Dep, Tabriz University Medical Sciences, Tabriz, Iran
    Burns 36:933-7. 2010
    Epidemiology of minor burns is not well defined worldwide. The aim of this study was to examine epidemiological features of minor and moderate burn events that could be beneficial for prevention purposes...
  90. doi Methylene blue in the treatment of vasoplegia following severe burns
    Amin D Jaskille
    Department of Surgery, Burn Center, Washington Hospital Center, Washington DC 20010, USA
    J Burn Care Res 29:408-10. 2008
    Vasoplegia resulting from severe burns may persist despite adequate fluid resuscitation and treatment with norepinephrine (NE), vasopressin (VP), and steroids...
  91. ncbi Involvement of the CXCL12/CXCR4 pathway in the recovery of skin following burns
    Shani Avniel
    Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, Jerusalem, Israel
    J Invest Dermatol 126:468-76. 2006
    ..The role of the CXCL12/CXCR4 pathway in the recovery of skin following burns is unknown...
  92. ncbi Pharmacological modulation of wound healing in experimental burns
    Abdo Jurjus
    Human Morphology, Faculty of Medicine, American University of Beirut Medical Center, Beirut, Lebanon
    Burns 33:892-907. 2007
    ..Such data are likely to be important for the development of novel strategies for wound healing since they shed some light on the potential formulations of temporally and combinatory optimized therapeutic regimens...
  93. ncbi Resistance due to aminoglycoside modifying enzymes in Pseudomonas aeruginosa isolates from burns patients
    M Shahid
    Department of Microbiology, J N Medical College and Hospital, Aligarh Muslim University, Aligarh, India
    Indian J Med Res 122:324-9. 2005
    ..The present study was therefore designed to determine resistance rates and patterns, and to find out the prevalent aminoglycoside modifying enzymes (AMEs) in clinical isolates of Pseudomonas aeruginosa from hospitalized burn patients...
  94. doi Falls, poisonings, burns, and road traffic injuries in urban Peruvian children and adolescents: a community based study
    J Donroe
    Asociacion Benefica PRISMA, San Miguel, Lima, Peru
    Inj Prev 15:390-6. 2009
    To identify individual and household characteristics associated with serious falls, poisonings, burns and road traffic injuries (RTIs) for children in Lima, Peru.
  95. doi Role of tumor necrosis factor-alpha and matrix metalloproteinase-9 in blood-brain barrier disruption after peripheral thermal injury in rats
    Raul Reyes
    Department of Neurosurgery, The University of Texas Health Science Center at San Antonio, Texas, USA
    J Neurosurg 110:1218-26. 2009
    ..In the present study, the authors examined whether tumor necrosis factor-alpha (TNF-alpha) and matrix metalloproteinase-9 (MMP-9) play a causative role in blood-brain barrier (BBB) disruption after peripheral thermal injury...
  96. doi Are topical antimicrobials effective against bacteria that are highly resistant to systemic antibiotics?
    Alice N Neely
    Microbiology Department, Shriners Hospitals for Children, Cincinnati, Ohio 45229, USA
    J Burn Care Res 30:19-29. 2009
    ..Some treatment assumptions based historically on the efficacy of topical antimicrobial agents against non-MDROs need to be re-evaluated for MDROs...
  97. doi Colloid administration normalizes resuscitation ratio and ameliorates "fluid creep"
    Amanda Lawrence
    Burn Trauma ICU, Department of Surgery, University of Utah College of Medicine, Salt Lake City, Utah, USA
    J Burn Care Res 31:40-7. 2010
    ..With Institutional Review Board approval, we reviewed all adult patients with > or =20%TBSA burns admitted from January 1, 2005, through December 31, 2007, who completed formal resuscitation...
  98. doi The Parkland formula under fire: is the criticism justified?
    Jennifer Blumetti
    University of Texas Southwestern, Dallas, Texas, USA
    J Burn Care Res 29:180-6. 2008
    ..0 ml/kg/hr. Over-resuscitation was defined as UOP > 1.0 ml/kg/hr. Patients were stratified according to UOP. Burns more than 19% TBSA were included. Electrical burns, trauma, and children (<15 years) were excluded...
  99. ncbi Cutaneous burns treated with hydrogel (Burnshield) and a semipermeable adhesive film
    Enzo Osti
    Emergency Department, Via Galleria San Donato 4, 30027 San Donà di Piave, Venice, Italy
    Arch Surg 141:39-42. 2006
    ....
  100. ncbi Burns inflicted by self or by others--an 11 year snapshot
    C C Malic
    Pinderfields General Hospital, Wakefield, UK
    Burns 33:92-7. 2007
    In the United Kingdom, the incidence of assault by burning and of self inflicted burns increased significantly over the last decade. This has major implications both for service providers and society as a whole...
  101. ncbi The use of fucosphere in the treatment of dermal burns in rabbits
    A D Sezer
    Department of Pharmaceutical Biotechnology, Marmara University, Istanbul, Turkey
    Eur J Pharm Biopharm 69:189-98. 2008
    ..system based on polyion complexation of fucoidan with chitosan, and to evaluate its treatment efficiency on dermal burns. The physicochemical properties such as mean particle size and distribution, zeta potential and bioadhesive ..

Research Grants76

  1. Ligand Directed Transdermal siRNA Delivery to Improve Wound Healing
    David M Evans; Fiscal Year: 2012
    ..Every year in the United States more than 1.25 million people suffer burns and 6.5 million have chronic skin ulcers caused by diabetes and other diseases...
  2. SUPPORT CONTRACT FOR THE NTP INTERAGENCY CENTER/VALIDATION OF ALT METHODS
    David Allen; Fiscal Year: 2009
    ..to warn consumers and workers when exposure to a chemical or product may cause skin injury (permanent scarring/burns) or irritation...
  3. Photodynamic Therapy of Localized Infections
    Michael R Hamblin; Fiscal Year: 2013
    ..highly active antimicrobial PS and demonstrated their effectiveness in treating mouse models of infected wounds, burns and abscesses...
  4. Optical Molecular Tomography for Regenerative Medicine
    Ge Wang; Fiscal Year: 2013
    ..neurological diseases, diabetes, arthritis, osteoporosis, kidney and liver failure, spinal cord injury, burns, battlefield trauma, and other devastating conditions...
  5. Best Management of Sigmoid Volvulus: a Prospective Randomized Trial
    JONATHAN CHARLES SAMUEL; Fiscal Year: 2013
    ..leading an interdisciplinary team studying surgical diseases such as sigmoid volvulus, traumatic injury and burns with bidirectional applicability, Dr Samuel requires further mentorship from established leaders in international ..
  6. Effect of Maspin on Corneal Heme-and lymph- angiogenesis
    Sally S Twining; Fiscal Year: 2013
    ..The normal cornea is avascular. Examples of conditions associated with corneal angiogenesis include chemical burns, chronic contact lens hypoxia, Stevens-Johnson syndrome, pterygia, graft rejection and infectious keratitis (2-4)...
  7. Imaging Strategies to Measure Brown Fat and Its Activity
    C Ronald Kahn; Fiscal Year: 2010
    ..Recent studies show that adults have a second type of fat called brown fat, which burns energy instead of storing it. Our research will develop the tools to measure the amount and activity of brown fat...
  8. Skin Regeneration with Stem Cells and Scaffolds
    SUSAN RENEE OPALENIK; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Wounds and burns frequently scar and fail to regenerate the original architecture of the skin...
  9. Enforcing Underage Drinking Laws (EUDL)
    Christopher Spera; Fiscal Year: 2009
    ..problems;increased risk of suicide and homicide;alcohol-related car crashes;unintentional injuries from burns, falls, and drownings;and death from alcohol poisoning...
  10. Proinflammatory Biomarkers and Post-Breast CancerLymphedema
    Mei Rosemary Fu; Fiscal Year: 2012
    ..to treatment-related trauma (such as surgery and radiation) and triggering factors (such as infection, burns, minor injuries, and higher BMI or obesity)...
  11. Trauma and Hemorrhage-Induced Skeletal Muscle Insulin Resistance
    JOSEPH LOUIS MESSINA; Fiscal Year: 2013
    ..are much less studied, but are characteristic metabolic responses to infections and injuries such as surgery, burns, trauma and hemorrhage...
  12. Effects of Metabolic Disorders on Bone Marrow-Derived Cell Function
    Gina C Schatteman; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: This work could lead to better treatment of heart attacks, strokes, and burns as well as prevention of chronic ulcers, particularly in people who are obese and those with diabetes.
  13. Regulation of TRPV1 and Nociceptor Sensitization by the Complement System
    Yuriy M Usachev; Fiscal Year: 2013
    ..various pathological states associated with pain, including arthritis, pancreatitis, inflammatory bowel disease, burns and surgical trauma...
  14. Molecular Control of Gut Permeability in Trauma
    Mack H Wu; Fiscal Year: 2013
    ..The intestinal permeability response to burns, a major form of trauma, has not been well characterized, and its cellular and molecular mechanisms remain poorly ..
  15. Augmentation of Innate Anti-Microbial Immunity by TLR4 Agonists
    Edward R Sherwood; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Large surface area burns cause loss of the protective skin barrier and dysregulation of antimicrobial defense mechanisms resulting in ideal conditions for colonization of burn wounds and ..
  16. Mesenchymal Stem Cells To Mitigate and Treat Cutaneous Injury Following Radiation
    William H McBride; Fiscal Year: 2010
    ..desquamation and/or dermal damage that is normally expressed late but can be precipitated by physical trauma, burns, or penetrating wounds...
  17. Lipid Mediators in Corneal Nerve Regeneration
    Haydee E P Bazan; Fiscal Year: 2013
    ..These alterations frequently occur after refractive surgery, corneal transplant, herpetic infection, chemical burns, keratoconus, multiple sclerosis, Sjogren's syndrome and diabetes mellitus...
  18. Molecular Biology and Gene Therapy in Burns and Trauma
    Lyle L Moldawer; Fiscal Year: 2013
    ..The successful trainees will have the expertise in functional genomics, gene therapy and molecular biology to help translate the current genetic revolution to trauma practice...
  19. Non-invasive neonatal respiration monitor
    ROSE MARIE VISCARDI; Fiscal Year: 2013
    ..Clark electrode;(3) potential membrane failure;(4) use of adhesives to maintain direct skin contact;(5) possible burns from raising skin temperature to 43[unreadable]C;(6) time-consuming due to large transcutaneous mass transfer ..
  20. NorLeu3-A(1-7): Enhanced Recovery of Radiation Burns
    Kathleen E Rodgers; Fiscal Year: 2010
    ..peptides can rapidly promote wound healing as well as hematopoiesis, both of which are needed in healing burns that result from radiation blasts...
  21. Dendritic Cell Activation by Mitochondrial Transcription Factor A
    Elliott D Crouser; Fiscal Year: 2010
    ..activated by "self-antigens" which are released during severe acute illnesses, such as trauma, pancreatitis or burns. Under these conditions, tissue damage results in widespread activation of the immune system in the absence of any ..
  22. STUDIES OF P2X ATP RECEPTORS
    RICHARD HUME; Fiscal Year: 2009
    ..of the structure of these receptors should allow the development of new treatments for this type of pain, and so greatly ease the suffering of individuals with burns and other injuries that produce persistent pain.
  23. Regulation of Pseudomonas aeruginosa type III secretion
    Timothy L Yahr; Fiscal Year: 2012
    ..commonly isolated from patients with cystic fibrosis, nosocomial pneumonias, urinary tract infections, or severe burns. A primary determinant of P. aeruginosa virulence is a type III secretion system (T3SS)...
  24. Live Attenuated Recombinant Bacterial Delivery of Polysaccharide Vaccine Antigens
    Joanna B Goldberg; Fiscal Year: 2010
    ..aeruginosa infections after corneal trauma or after burns, but do not know the optimal route of immunization to induce immunity at these different sites, nor do we know the ..
  25. Novel Angiogenesis Inhibitors Targeting the Anthrax Toxin Receptors
    MICHAEL SEAN ROGERS; Fiscal Year: 2012
    ..and glaucoma, corneal neovascularization associated with conditions such as Herpetic Keratitis, Trachoma, burns, and revascularization of corneal transplants, and other angiogenesis-dependant diseases such as cancer, arthritis,..
  26. The Role of Genetic Variation in Alzheimer's Disease
    Robyn A Honea; Fiscal Year: 2013
    ..Jeffrey Burns to learn Alzheimer's disease clinical methodology. Dr...
  27. Localized Metal Modulation as a First Line Treatment of Burn Injuries
    JERRY GIN; Fiscal Year: 2012
    ..Increased amounts of oxidants generated endogenously early on in burns cause increased lipid peroxidation and iron dependent formation of cytotoxic lipid aldehydes, such as 4- ..
  28. Development of an Atmospheric Plasma Applicator to Treat Chronic Wounds
    Kimberly Kelly-Wintenberg; Fiscal Year: 2011
    ..arterial disease, lower extremity venous disease and edema, and pressure ulcers, and traumatic injuries, including burns. There is a real need for new advanced technologies to treat chronic wounds since a significant number of these ..
  29. Human Brown Adipose Tissue and its Impact on Metabolism
    AARON MARTIN CYPESS; Fiscal Year: 2013
    ..Our research will show that brown fat burns calories and is important for weight loss...
  30. Surgical Studies of Gut Permeability
    Jian Ying Wang; Fiscal Year: 2013
    ..Disruption of the gut epithelial barrier occurs commonly in various critical surgical conditions such as trauma, burns, hemorrhage, sepsis, and massive surgical operations, leading to the translocation of luminal toxic substances and ..
  31. Tear-Resistant and Elastic Tissue Adhesive for Craniofacial Applications
    SILVIA D LUEBBEN; Fiscal Year: 2012
    ..Finally they cannot be used to cover large abrasions, wounds or burns because they would crack during body movement. In this project TDA Research, Inc...
  32. Lung epithelium collaborates with alveolar macrophages in host defense
    Min Wu; Fiscal Year: 2012
    ..infections, particularly in immunodeficient individuals who are suffering tuberculosis, cancer, AIDS, severe burns, and cystic fibrosis...
  33. Mechanisms of Impaired Erythropoiesis in Post Burn Anemia of Critical Illness
    KUZHALI MUTHUMALAIAPPAN; Fiscal Year: 2013
    ..hemopoietic transcription factors MafB and GATA-1 in regulating the impairment of bone marrow erythropoiesis after burns through intervention using loss of function and gain of expression studies and later evaluate the gain of Epo ..
  34. Adaptive Optics Instrumentation for Advanced Ophthalmic Imaging
    David R Williams; Fiscal Year: 2012
    ..Other lead investigators include: Steve Burns (Indiana University) an international leader in laser scanning ophthalmoscopy, John Flannery (UC, Berkeley) an ..
  35. Phase III infliximab for primary treatment of Kawasaki disease IND 11046 6/27/200
    Jane C Burns; Fiscal Year: 2012
    ..fever, will require additional therapy, and will be at increased risk of developing coronary artery abnormalities (Burns et al. 1998;Tremoulet et al. 2008)...
  36. Effect of Insulin and Propranolol on Post Burn Hypermetabolism and Inflammation
    David N Herndon; Fiscal Year: 2012
    ABSTRACT Massive burns are associated with a persistent and sustained hypermetabolic response characterized by elevated levels of circulating catecholamines, cytokines and cortisol, which cause muscle wasting, immunodeficiency, organ ..
  37. Skin Stem Cells in Combined Radiation Injury
    Nelson J Chao; Fiscal Year: 2012
    ..but would not be considered life threatening unless that exposure occurred with simultaneous physical trauma or burns. In many terrorist radiation exposure scenarios, injury will likely involve radiation exposure and additional, ..
  38. Dual role of complement in post-ischemic inflammation and recovery
    Stephen Tomlinson; Fiscal Year: 2012
    ..g., hemorrhagic shock, severe burns, sepsis, myocardial infarction, stroke, transplant dysfunction/rejection)...
  39. Use of a Nitric Oxide-Loaded Gel to Improve Healing Outcomes of Burn Injuries
    William R Kelce; Fiscal Year: 2012
    ..In the United States, 450,000 experience burns requiring hospitalization and 3,500 of these lead to fatal outcomes...
  40. Cytokine Regulation of Muscle Protein Synthesis During Infection
    Charles H Lang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Muscle wasting remains a cause of morbidity and mortality after trauma, burns and infection...
  41. AMPK activation and acute lung injury
    JAROSLAW WALDEMAR ZMIJEWSKI; Fiscal Year: 2013
    ..is frequently associated with infection, but can also arise from other predisposing events including hemorrhage, burns, or injurious mechanical ventilation...
  42. Therapeutic Small Molecule Modulators of G beta gama Signaling
    Val S Goodfellow; Fiscal Year: 2011
    ..Professors Alan Smrcka, Burns Blaxall and Jean Bidlack at the University of Rochester Medical Center (URMC) have developed a novel strategy for ..
  43. Natural Killer T Cell Modulation of Cutaneous Wound Healing
    Elizabeth J Kovacs; Fiscal Year: 2010
    ..Using two different mouse models of wound healing (scald burns and excisional wounds), two different strains of NKT cell deficient mice, and systemic blockade of NKT cell ..
  44. Ameliorating systemic gentamicin uptake by sensory hair cells
    PETER STEPHEN STEYGER; Fiscal Year: 2013
    ..judiciously and personalize gentamicin therapy for individual cases prior to treatment for life-threatening bacterial sepsis, tuberculosis and for prophylaxis in premature babies, and casualties with severe burns and blast injuries.
  45. Mitigation of the Catecholamine Surge in Severely Burned Patients
    David N Herndon; Fiscal Year: 2013
    ..The hypermetabolic response to burns is also characterized by a profound tachycardia and increased cardiac work that are detrimental to the heart...
  46. Cholinergic regulation of endothelial cell activation
    Christine N Metz; Fiscal Year: 2010
    Sepsis, a major complication following trauma, burns and/or surgery, is the leading cause of death in the intensive care unit nationwide...
  47. Pediatric Heart Network University of Utah
    RICHARD VINCENT WILLIAMS; Fiscal Year: 2013
    ..The drug has few side effects and has improved weight gain in children with extensive burns and improved growth in children with short stature, including girls with Turner's syndrome...
  48. Peptide-coated skin substitutes for the treatment of burn injuries and wounds
    Bruce Lamb; Fiscal Year: 2012
    ..Each year in the US, there are 450,000 burns that require medical treatment and 45,000 burns that require hospitalization...
  49. Hepatic Insulin Resistance Following Hemorrhage
    JOSEPH LOUIS MESSINA; Fiscal Year: 2013
    ..resistance and hyperglycemia are characteristic metabolic responses to infections and injury such as surgery, burns, trauma and hemorrhage...
  50. "Smart" Grounding Pad for safer use in the RFA of Cancer
    TERENCE HENDRICKS; Fiscal Year: 2012
    ..However, as the power of RF ablation systems has increased over the years, the incidence of skin burns at the grounding pad sites has increased as well...
  51. CONSTRUCTION AND ANALYSIS OF RETROVIRUS MUTANTS
    STEPHEN PAINE GOFF; Fiscal Year: 2013
    ..Margaret Wang Columbia University Juliana Leung Columbia University Frank Appah Columbia University Anne Burns Columbia University in the format shown below, Role on Project Principal Investigator Postdoctoral Res. Sci. Grad...
  52. Noninvasive Measurement of UCP1 in Brown Adipose Tissue
    Joel K Yisraeli; Fiscal Year: 2012
    ..forms of fat: white adipose tissue (WAT), which stores energy, and brown adipose tissue (BAT), which burns energy for thermogenesis...
  53. Engineered Matrix Mimetics: Novel Therapies for Wound Repair
    Denise C Hocking; Fiscal Year: 2012
    ..New treatment approaches are needed to rapidly close burns and chronic wounds to decrease the risk of infection, prevent fluid loss, and promote the natural healing process...
  54. Novel Imaging System to Objectively Assess the Natural History of Treated and Unt
    Jessica C Ramella Roman; Fiscal Year: 2011
    ..It is commonly seen in patients who are injured by burns. There is no proven effective standard treatment for this condition...
  55. Advancing Native Health and Wellness Conference
    MARJORIE K LEIMOMI MALA MAU; Fiscal Year: 2012
    ..b>Burns School of Medicine at the University of Hawaii and the Association of American Indian Physicians (AAIP)...
  56. Training Grant in Trauma, Burn and Wound Healing
    Cynthia L Marcelo; Fiscal Year: 2013
    ..RELEVANCE (See instructions): For American scientist to continue to develop new therapies to treat patients with burns, traumatic injuries such as loss of limbs, and all types of severe wounds, physician scientist need to be trained ..
  57. Maintenance of the Hematopoietic Stem Cell Niche Monocytes and Macrophages
    Andrew Chow; Fiscal Year: 2012
    ..broad implications for the maintenance of non-hematopoietic stem cell niches, whose manipulation can be instrumental in facilitating tissue repair after injuries, such as myocardial infarction, traumatic burns, and neurodegeneration.
  58. Antibacterial Molecular Coatings Pre-Fabricated for Biologic Wound Dressings
    Ankit Agarwal; Fiscal Year: 2012
    ..Biologic dressings provide superior healing rates in burns and chronic wounds...
  59. Mechanisms for Wound Healing with Ultrasound
    Denise C Hocking; Fiscal Year: 2012
    ..New treatment methods are needed to rapidly close burns and chronic wounds, prevent infection and fluid loss, and promote the natural healing process...
  60. Institute for Biogenesis Research: COBRE
    WILLIAM S WARD; Fiscal Year: 2012
    The John A. Burns School of Medicine (JABSOM) at the University of Hawa'fi at Manoa (UH Manoa) is submitting this application in response to National Institutes of Health (NIH) PAR-07-229...
  61. Cochlear trafficking and hair cell uptake of aminoglycosides
    PETER STEPHEN STEYGER; Fiscal Year: 2013
    ..uptake of aminoglycosides will allow clinicians to use aminoglycosides more aggressively for treating life-threatening bacterial sepsis, specific agents of bioterrorism, and for prophylaxis in combat, severe burns and blast injuries.
  62. TRAUMA AND INFLAMMATION RESEARCH TRAINING
    Irshad H Chaudry; Fiscal Year: 2010
    ..The Center for Surgical Research and the Department of Surgery including Trauma/Burns and Surgical Critical Care, Neurosurgery, Orthopedic Surgery, Chemoprevention Center, Islet Transplant Center, and ..
  63. Nitric Oxide Releasing Topical Gel for Burn Wound Healing
    ANJAL SHARMA; Fiscal Year: 2007
    ..applications, and thus allows for application of a topical 'gel' to wound treatments - specifically burns. This proprietary chemical method for the synthesis of NO in a gel format has the potential to be used as a ..
  64. Somatic Stem Cells in Engineered Human Skin
    Steven Boyce; Fiscal Year: 2009
    ..has delivered new medical benefits to patients with acute skin wounds arising from extensive, full-thickness burns, but applications of these devices to elective surgery (i.e...
  65. Functional similarities in renal and cochlear epithelia
    PETER STEYGER; Fiscal Year: 2004
    ..g., meningitis, and in preventing infection in burns and premature babies. However, there is a high incidence of ototoxicity and sensory hair cell death...
  66. LIQUID VENTILATION IN ARDS
    Ronald Hirschl; Fiscal Year: 2000
    ..complication associated with atelectasis, pneumonia, and lung injury following operation, sepsis, trauma, and burns. Perfluorocarbons are inert, colorless, high-density, low surface tension liquids which carry large quantities of ..
  67. Enhanced Cryoprecipiate in Wound Healing
    Edward Shanbrom; Fiscal Year: 2007
    ..Patients with extensive wounds and burns often require skin grafts for healing to occur...
  68. MECHANISMS OF PHOSPHOLIPASE A2 REGULATION
    John Bell; Fiscal Year: 1990
    ..a number of diseases including rheumatoid arthritis inflammatory hyperemia, inflammatory problems associated with burns and trauma, eczema, psoriasis, pancreatitis, trypanosomiasis, amoebiasis, myocardial infarction, ischemia, ..
  69. ISCHEMIA/REPERFUSION INJURY IN SURGERY AND TRAUMA
    Nicholas Vedder; Fiscal Year: 2000
    ..models of important surgical and trauma-related disease processes, including tissue and organ ischemia, shock, and burns. The mechanisms involved in the regulation of endothelial CD62P expression in the setting of ischemia-reperfusion, ..
  70. Restoring Hematopoiesis Following Radiation Injury
    Amelia Bartholomew; Fiscal Year: 2005
    Following acute radiation exposure, in addition to traumatic injuries such as fractures, lacerations, and burns, radiation syndromes involving the central nervous, gastrointestinal, cutaneous, and hematopoietic systems can ensue...
  71. Dissemination of Effective MH Services in Foster Care
    Sonya J Leathers; Fiscal Year: 2010
    ..who experience three to four times the rate of mental health problems than in the general population of children (Burns et al., 2004;Leslie et al., 2005)...
  72. IDENTIFY LIMBAL STEM CELLS BY CELL SURFACE MARKERS
    Ronald Smith; Fiscal Year: 2005
    Damage to the limbal epithelial cells can be caused by chemical or thermal burns, the Stevens-Johnson syndrome, ocul cicatrIcial pemphigoid, contact lenses, severe infection, congenital aniridia, pterygium, herpes simplex epithelial ..
  73. REGULATION OF VOCAL FOLD HYDRATION AND PHONATION
    Kimberly Fisher; Fiscal Year: 2003
    ..cancerous and cancerous lesions, scarring and drying from drugs, dehydrated air, radiation, thermal or chemical burns. A rationale for future treatments demands that we understand how to regulate the mechanisms that control vocal ..
  74. MECHANISMS OF NEUTROPHIL DYSFUNCTION IN BURNS AND TRAUMA
    Joseph Solomkin; Fiscal Year: 1993
    ..Information from this project will provide insight into mechanisms producing ARDS and will allow precise definition of potential therapeutic strategies...
  75. Role of Selectins in Burns and Inhalation Injury
    Daniel Traber; Fiscal Year: 2009
    ..These aims should result in a better understanding of the injury and reduce the mortalities of ARDS patients. ..
  76. ALTERATIONS IN NEUROMUSCULAR FUNCTION FOLLOWING BURNS
    JEEVENDRA MARTYN; Fiscal Year: 2006
    Muscle weakness accompanies all forms of critical illnesses including burns, resulting in hypoventilation, dependence on respirators, and decreased mobilization, all of which lead to increased morbidity and mortality...