wounds and injuries

Summary

Summary: Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.

Top Publications

  1. ncbi The effect of plasma transfusion on morbidity and mortality: a systematic review and meta-analysis
    Mohammad Hassan Murad
    Knowledge and Encounter Research Unit, the Division of Preventive Medicine, and the Department of Transfusion Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Transfusion 50:1370-83. 2010
  2. ncbi A high admission syndecan-1 level, a marker of endothelial glycocalyx degradation, is associated with inflammation, protein C depletion, fibrinolysis, and increased mortality in trauma patients
    Pär I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Ann Surg 254:194-200. 2011
  3. ncbi Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis
    Yaojiong Wu
    161 HMRC, University of Alberta, 113 Street and 87 Avenue, Edmonton, Alberta T6G 2E1, Canada
    Stem Cells 25:2648-59. 2007
  4. ncbi Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial
    Haleema Shakur
    Clinical Trials Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Lancet 376:23-32. 2010
  5. ncbi Development of a common outcome data set for fall injury prevention trials: the Prevention of Falls Network Europe consensus
    Sarah E Lamb
    Warwick Emergency Care and Rehabilitation, University of Warwick, Coventry, UK
    J Am Geriatr Soc 53:1618-22. 2005
  6. ncbi The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital
    Matthew A Borgman
    Brooke Army Medical Center, Fort Sam Houston, TX, USA
    J Trauma 63:805-13. 2007
  7. ncbi The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial
    Ian Roberts
    Clinical Trials Unit, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Lancet 377:1096-101, 1101.e1-2. 2011
  8. pmc Management of bleeding following major trauma: an updated European guideline
    Rolf Rossaint
    Department of Anaesthesiology, University Hospital Aachen, RWTH Aachen University, Pauwelsstrasse 30, Aachen, Germany
    Crit Care 14:R52. 2010
  9. pmc The global burden of unintentional injuries and an agenda for progress
    Aruna Chandran
    International Injury Research Unit, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Epidemiol Rev 32:110-20. 2010
  10. ncbi Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients
    John B Holcomb
    United States Army Institute of Surgical Research, Ft Sam Houston, TX 78234, USA
    Ann Surg 248:447-58. 2008

Detail Information

Publications322 found, 100 shown here

  1. ncbi The effect of plasma transfusion on morbidity and mortality: a systematic review and meta-analysis
    Mohammad Hassan Murad
    Knowledge and Encounter Research Unit, the Division of Preventive Medicine, and the Department of Transfusion Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Transfusion 50:1370-83. 2010
    ..We systematically reviewed the literature to summarize the available evidence regarding the benefits and harms of plasma transfusion in common clinical settings...
  2. ncbi A high admission syndecan-1 level, a marker of endothelial glycocalyx degradation, is associated with inflammation, protein C depletion, fibrinolysis, and increased mortality in trauma patients
    Pär I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Ann Surg 254:194-200. 2011
    ..To investigate the association between markers of acute endothelial glycocalyx degradation, inflammation, coagulopathy, and mortality after trauma...
  3. ncbi Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis
    Yaojiong Wu
    161 HMRC, University of Alberta, 113 Street and 87 Avenue, Edmonton, Alberta T6G 2E1, Canada
    Stem Cells 25:2648-59. 2007
    ..Thus, our data suggest that BM-MSCs promote wound healing through differentiation and release of proangiogenic factors. Disclosure of potential conflicts of interest is found at the end of this article...
  4. ncbi Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial
    Haleema Shakur
    Clinical Trials Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Lancet 376:23-32. 2010
    ..We assessed the effects of early administration of a short course of tranexamic acid on death, vascular occlusive events, and the receipt of blood transfusion in trauma patients...
  5. ncbi Development of a common outcome data set for fall injury prevention trials: the Prevention of Falls Network Europe consensus
    Sarah E Lamb
    Warwick Emergency Care and Rehabilitation, University of Warwick, Coventry, UK
    J Am Geriatr Soc 53:1618-22. 2005
    ..Work is being undertaken in a 4-year program. As a first step, the development of a common set of outcome definitions and measures for future trials or meta-analysis was considered...
  6. ncbi The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital
    Matthew A Borgman
    Brooke Army Medical Center, Fort Sam Houston, TX, USA
    J Trauma 63:805-13. 2007
    ..The risk of death from hemorrhagic shock increases in this population. To treat the coagulopathy of trauma, some have suggested early, aggressive correction using a 1:1 ratio of plasma to red blood cell (RBC) units...
  7. ncbi The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial
    Ian Roberts
    Clinical Trials Unit, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Lancet 377:1096-101, 1101.e1-2. 2011
    ..Tranexamic acid significantly reduced all-cause mortality. Because tranexamic acid is thought to exert its effect through inhibition of fibrinolysis, we undertook exploratory analyses of its effect on death due to bleeding...
  8. pmc Management of bleeding following major trauma: an updated European guideline
    Rolf Rossaint
    Department of Anaesthesiology, University Hospital Aachen, RWTH Aachen University, Pauwelsstrasse 30, Aachen, Germany
    Crit Care 14:R52. 2010
    ..Evidence-based recommendations are needed to guide the acute management of the bleeding trauma patient, which when implemented may improve patient outcomes...
  9. pmc The global burden of unintentional injuries and an agenda for progress
    Aruna Chandran
    International Injury Research Unit, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Epidemiol Rev 32:110-20. 2010
    ....
  10. ncbi Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients
    John B Holcomb
    United States Army Institute of Surgical Research, Ft Sam Houston, TX 78234, USA
    Ann Surg 248:447-58. 2008
    ....
  11. ncbi Prevention of falls and consequent injuries in elderly people
    Pekka Kannus
    Accident and Trauma Research Centre, UKK Institute for Health Promotion Research, Tampere, Finland
    Lancet 366:1885-93. 2005
    ..Care must be taken, however, to rigorously select the right actions for those people most likely to benefit, such as vitamin D and calcium supplementation and hip protectors for elderly people living in institutions...
  12. ncbi Injury-related fatalities in China: an under-recognised public-health problem
    S Y Wang
    Centre for Injury Prevention and Control, Medical College of Jinan University, Guangzhou, Guangdong, China
    Lancet 372:1765-73. 2008
    ..China needs to improve monitoring of fatal and non-fatal injuries, promote intersectoral collaboration, build institutional capacities, and, most importantly, mobilise community support and political will for investment in prevention...
  13. pmc Live imaging of innate immune cell sensing of transformed cells in zebrafish larvae: parallels between tumor initiation and wound inflammation
    Yi Feng
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, United Kingdom
    PLoS Biol 8:e1000562. 2010
    ..These parallels between the inflammatory responses to transformed cells and to wounds reinforce the suggestion by others that cancers resemble non-healing wounds...
  14. ncbi Cohort profile: The Thai Cohort of 87,134 Open University students
    Adrian C Sleigh
    National Centre for Epidemiology and Population Health, ANU College of Medicine and Health Sciences, The Australian National University, Canberra, Australia
    Int J Epidemiol 37:266-72. 2008
  15. ncbi Impact of hemorrhage on trauma outcome: an overview of epidemiology, clinical presentations, and therapeutic considerations
    David S Kauvar
    United States Army Institute of Surgical Research, Fort Sam Houston, San Antonio, Texas 78234, USA
    J Trauma 60:S3-11. 2006
    ..Improvements in early hemorrhage control and resuscitation and the prevention and aggressive treatment of coagulopathy appear to have the greatest potential to improve outcomes in severely injured trauma patients...
  16. ncbi Evidence for quality indicators to evaluate adult trauma care: a systematic review
    Henry T Stelfox
    Department of Critical Care Medicine, Medicine and Community Health Sciences, University of Calgary, Calgary, Alberta, Canada
    Crit Care Med 39:846-59. 2011
    ..We sought to systematically review the evidence about the reliability, validity, and implementation of quality indicators for evaluating trauma care...
  17. ncbi Resolution of inflammation by retrograde chemotaxis of neutrophils in transgenic zebrafish
    Jonathan R Mathias
    University of Wisconsin Madison, 2715 Medical Sciences Center, 1300 University Ave, Madison, WI 53706, USA
    J Leukoc Biol 80:1281-8. 2006
    ..The zMPO:GFP zebrafish provides unique insight into the mechanisms of neutrophil-mediated inflammation and thereby offers opportunities to identify new regulators of the inflammatory response in vivo...
  18. ncbi Mechanism, glasgow coma scale, age, and arterial pressure (MGAP): a new simple prehospital triage score to predict mortality in trauma patients
    Danielle Sartorius
    Department of Emergency Medicine and Surgery, Université Lyon 1 and Hospices Civils de Lyon, Lyon, France
    Crit Care Med 38:831-7. 2010
    ..Prehospital triage of trauma patients is of paramount importance because adequate trauma center referral improves survival. We developed a simple score that is easy to calculate in the prehospital phase...
  19. ncbi Damage control resuscitation: directly addressing the early coagulopathy of trauma
    John B Holcomb
    USAISR, Fort Sam Houston, TX 78234 6315, USA
    J Trauma 62:307-10. 2007
  20. ncbi Prioritization of competing damage and developmental signals by migrating macrophages in the Drosophila embryo
    Severina Moreira
    Department of Biochemistry and Department of Physiology and Pharmacology, University of Bristol, BS8 1TD Bristol, UK
    Curr Biol 20:464-70. 2010
    ....
  21. ncbi Early evaluation of acute traumatic coagulopathy by thrombelastography
    Roger C Carroll
    Department of Anesthesiology, University of Tennessee Graduate School of Medicine, Knoxville, Tenn 37920, USA
    Transl Res 154:34-9. 2009
    ..These coagulopathies were already evident OS. The TEG assays can assess coagulopathy, platelet dysfunction, and hyperfibrinolysis at an early stage posttrauma and suggest more effective interventions...
  22. ncbi The coagulopathy of trauma: a review of mechanisms
    John R Hess
    Department of Pathology, University of Maryland Medical Center, Baltimore, Maryland 21201, USA
    J Trauma 65:748-54. 2008
    ..Coagulopathy associated with severe injury complicates the control of bleeding and is associated with increased morbidity and mortality in trauma patients. The causes and mechanisms are multiple and yet to be clearly defined...
  23. pmc Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds
    Howard Y Chang
    Department of Dermatology, Stanford University School of Medicine, Stanford, California, USA
    PLoS Biol 2:E7. 2004
    ..Thus, the transcriptional signature of the response of fibroblasts to serum provides a possible link between cancer progression and wound healing, as well as a powerful predictor of the clinical course in several common carcinomas...
  24. pmc Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway?
    Karim Brohi
    Department of Surgery, University of California at San Francisco, San Francisco, CA, USA
    Ann Surg 245:812-8. 2007
    ..We hypothesized that early coagulopathy is due to tissue hypoperfusion, and investigated derangements in coagulation associated with this...
  25. ncbi Postinjury multiple organ failure
    David Dewar
    Department of Traumatology, John Hunter Hospital and University of Newcastle, NSW, Australia
    Injury 40:912-8. 2009
    ....
  26. pmc The neglected epidemic: road traffic injuries in developing countries
    Vinand M Nantulya
    Harvard Center for Population and Development Studies, Cambridge, MA 02138, USA
    BMJ 324:1139-41. 2002
  27. pmc Safety in numbers: more walkers and bicyclists, safer walking and bicycling
    P L Jacobsen
    Public Health Consultant, 4730 Monterey Way, Sacramento, CA 95822, USA
    Inj Prev 9:205-9. 2003
    ..However, three published analyses of collision rates at specific intersections found a non-linear relationship, such that collisions rates declined with increases in the numbers of people walking or bicycling...
  28. ncbi The lifetime prevalence of traumatic events and posttraumatic stress disorder in the Netherlands
    Giel Jan de Vries
    Centre for Psychological Trauma, Department of Psychiatry, Academic Medical Centre, AMC de Meren, 1105 AZ, Amsterdam, The Netherlands
    J Trauma Stress 22:259-67. 2009
    ..Unexpectedly, prevalence rates resemble those found in the United States and are higher than in several other European countries...
  29. ncbi Partner violence and health: results from the first national study on violence against women in Norway
    Astrid Irene Nerøien
    Department of Public Health and General Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Scand J Public Health 36:161-8. 2008
    ..Questions about violence have not been included in health surveys; hence, little is known about prevalence and the consequences for health in the general population. No national study has been conducted in Norway...
  30. ncbi The burden of road traffic injuries in developing countries: the 1st national injury survey of Pakistan
    Abdul Ghaffar
    Health Services Academy, Islamabad, Pakistan
    Public Health 118:211-7. 2004
    ..To assess the burden of road traffic injuries in Pakistan-a developing country in South Asia...
  31. ncbi Functional outcome at 2.5, 5, 9, and 24 months after injury in the Netherlands
    Suzanne Polinder
    Department of Public Health, ErasmusMC University Medical Center Rotterdam, The Netherlands
    J Trauma 62:133-41. 2007
    ..The collection of empirical data on the frequency, severity, and duration of functioning is a prerequisite to identify patient groups with long term or permanent disability...
  32. ncbi Rapid thrombelastography delivers real-time results that predict transfusion within 1 hour of admission
    Bryan A Cotton
    Department of Surgery, The University of Texas Health Science Center, Houston, Texas 77030, USA
    J Trauma 71:407-14; discussion 414-7. 2011
    ..The purpose of this pilot study was to evaluate the timeliness of r-TEG results, their correlation with CCTs, and the ability of r-TEG to predict early blood transfusion...
  33. ncbi Regional cerebral blood flow in the amygdala and medial prefrontal cortex during traumatic imagery in male and female Vietnam veterans with PTSD
    Lisa M Shin
    Department of Psychology, Tufts University, Medford, MA 02155, USA
    Arch Gen Psychiatry 61:168-76. 2004
    ..However, the functional relationship between these brain regions in PTSD has not been directly examined...
  34. ncbi Primary fibrinolysis is integral in the pathogenesis of the acute coagulopathy of trauma
    Jeffry L Kashuk
    Division of Trauma, Acute Care, and Critical Care Surgery, Department of Surgery, Penn State Hershey Medical Center, College of Medicine, Hershey, PA 17033, USA
    Ann Surg 252:434-42; discussion 443-4. 2010
    ..We hypothesized that postinjury PF occurs early in severe shock, leading to postinjury coagulopathy, and ultimately hemorrhage-related death...
  35. ncbi Acute coagulopathy of trauma: balancing progressive catecholamine induced endothelial activation and damage by fluid phase anticoagulation
    P I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Med Hypotheses 75:564-7. 2010
    ..The implications of this hypothesis may include targeted treatment strategies according to the degree of sympathoadrenal response as evaluated by whole blood viscoelastical hemostatic assays in trauma patients...
  36. ncbi Increased number of coagulation products in relationship to red blood cell products transfused improves mortality in trauma patients
    Beth H Shaz
    Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Transfusion 50:493-500. 2010
    ..This study investigates the relationship of plasma:RBC, PLT:RBC, and cryoprecipitate:RBC transfusion ratios to mortality in massively transfused patients at a civilian Level 1 trauma center...
  37. ncbi Effect of blood products transfusion on the development of postinjury multiple organ failure
    Jeffrey L Johnson
    Department of Surgery, University of Colorado Denver, USA
    Arch Surg 145:973-7. 2010
    ..Transfusion of fresh frozen plasma (FFP) and platelets is independently associated with the development of multiple organ failure (MOF) in critically injured patients...
  38. ncbi Intimate partner violence and physical health consequences
    Jacquelyn Campbell
    School of Nursing, The Johns Hopkins University, 525 N Wolfe St, Room 436, Baltimore, MD 21205 2110, USA
    Arch Intern Med 162:1157-63. 2002
    ..Domestic violence results in long-term and immediate health problems. This study compared selected physical health problems of abused and never abused women with similar access to health care...
  39. pmc Acute traumatic injuries in rural populations
    Corinne Peek-Asa
    Am J Public Health 94:1689-93. 2004
    ..We describe differences in rates and patterns of injury among rural and urban populations and discuss factors that contribute to these differences...
  40. ncbi Quality indicators for evaluating trauma care: a scoping review
    Henry Thomas Stelfox
    Department of Critical Care Medicine, Foothills Medical Centre, University of Calgary, 1403 29 St NW, Calgary, Alberta, Canada
    Arch Surg 145:286-95. 2010
    ..To systematically review the literature on quality indicators (QIs) for evaluating trauma care, identify QIs, map their definitions, and examine the evidence base in support of the QIs...
  41. pmc Chronic maternal depression and children's injury risk
    David C Schwebel
    Department of Psychology, University of Alabama at Birmingham, 1300 University Blvd, CH 415, Birmingham AL 35294, USA
    J Pediatr Psychol 33:1108-16. 2008
    ..One understudied consequence of maternal depression is how it affects toddlers' injury risk. This study examined links between chronic maternal depression and child injury...
  42. pmc Incidence and costs of unintentional falls in older people in the United Kingdom
    P Scuffham
    York Health Economics Consortium Ltd, University of York, UK
    J Epidemiol Community Health 57:740-4. 2003
    ..To estimate the number of accident and emergency (A&E) attendances, admissions to hospital, and the associated costs as a result of unintentional falls in older people...
  43. ncbi A systematic review of early prognostic factors for return to work following acute orthopaedic trauma
    Fiona J Clay
    Monash University, Accident Research Centre, Clayton, Victoria 3800, Australia
    Injury 41:787-803. 2010
    ..This study aims to synthesise and summarise current knowledge concerning prognostic factors for return to work and duration of work disability following acute orthopaedic trauma...
  44. ncbi Preventing injuries in older people by preventing falls: a meta-analysis of individual-level data
    M Clare Robertson
    Department of Medical and Surgical Sciences, Otago Medical School, University of Otago, Dunedin, New Zealand
    J Am Geriatr Soc 50:905-11. 2002
    ..The objectives of this meta-analysis of these trials were to estimate the overall effect of the exercise program on the numbers of falls and fall-related injuries and to identify subgroups that would benefit most from the program...
  45. ncbi A statewide system of trauma care in Victoria: effect on patient survival
    Peter A Cameron
    Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Vic, Australia
    Med J Aust 189:546-50. 2008
    ..To determine whether the statewide system of trauma care introduced in 2000 has resulted in improved survival for all major trauma patients in Victoria...
  46. ncbi Distribution and determinants of health and work status in a comprehensive population of injury patients
    Willem Jan Meerding
    Department of Public Health, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    J Trauma 56:150-61. 2004
    ..We report on a large follow-up study in a comprehensive population of injury patients...
  47. pmc Incidence and burden of road traffic injuries in urban India
    R Dandona
    George Institute for International Health India, Hyderabad, India
    Inj Prev 14:354-9. 2008
    ..The scale of road traffic injuries (RTIs) in India is uncertain because of limitations in the availability and reliability of incidence data...
  48. ncbi Diagnosis of early coagulation abnormalities in trauma patients by rotation thrombelastography
    L Rugeri
    Laboratory of Haemostasis, Edouard Herriot Hospital, Hospices Civils de Lyon and Claude Bernard University, Lyon, France
    J Thromb Haemost 5:289-95. 2007
    ..A hemostatic monitor capable of rapid and accurate detection of clinical coagulopathy within the resuscitation room could improve management of bleeding after trauma...
  49. ncbi The Ca2+-binding proteins S100A8 and S100A9 are encoded by novel injury-regulated genes
    I S Thorey
    Institute of Cell Biology, , , , Switzerland
    J Biol Chem 276:35818-25. 2001
    ....
  50. ncbi Guidelines for the conduction of follow-up studies measuring injury-related disability
    Ed F van Beeck
    Department of Public Health, Erasmus MC, University Medical Centre Rotterdam, The Netherlands
    J Trauma 62:534-50. 2007
    ..During the past decade, a variety of measures have been used at various moments in different study populations. Guidelines are needed to increase comparability between studies...
  51. ncbi Measuring the population burden of fatal and nonfatal injury
    Suzanne Polinder
    Department of Public Health, Erasmus MC University Medical Center Rotterdam, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Epidemiol Rev 34:17-31. 2012
    ..Recommendations are given for methodological refinements to improve the validity and comparability of future burden of injury studies...
  52. pmc Thrombelastography and tromboelastometry in assessing coagulopathy in trauma
    Pär I Johansson
    Regional Blood Bank, Rigshospitalet, University of Copenhagen, Denmark
    Scand J Trauma Resusc Emerg Med 17:45. 2009
    ....
  53. pmc Transfusion in trauma: thromboelastometry-guided coagulation factor concentrate-based therapy versus standard fresh frozen plasma-based therapy
    Herbert Schöchl
    Ludwig Boltzmann Institute of Experimental and Clinical Traumatology, Donaueschingenstrasse 13, A 1200 Vienna, Austria
    Crit Care 15:R83. 2011
    ....
  54. ncbi Enhanced epithelial gap closure and increased angiogenesis in wounds of diabetic mice treated with adult murine bone marrow stromal progenitor cells
    Elisabeth H Javazon
    Department of Surgery, The Children s Center for Fetal Research, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Wound Repair Regen 15:350-9. 2007
    ..We conclude that topical application of BM-derived SPCs may represent an effective strategy for the treatment of chronic diabetic wounds...
  55. ncbi Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response
    G S Ashcroft
    Laboratory of Cell Regulation and Carcinogenesis, NCI, Bethesda, Maryland 20892 5055, USA
    Nat Cell Biol 1:260-6. 1999
    ..These data are, to our knowledge, the first to implicate Smad3 in specific pathways of tissue repair and in the modulation of keratinocyte and monocyte function in vivo...
  56. pmc Goal-directed coagulation management of major trauma patients using thromboelastometry (ROTEM)-guided administration of fibrinogen concentrate and prothrombin complex concentrate
    Herbert Schöchl
    Department of Anaesthesiology and Intensive Care, AUVA Trauma Hospital, Dr Franz Rehrl Platz 5, Salzburg, Austria
    Crit Care 14:R55. 2010
    ..The appropriate strategy for trauma-induced coagulopathy management is under debate. We report the treatment of major trauma using mainly coagulation factor concentrates...
  57. ncbi Trauma systems and early management of severe injuries in Scandinavia: review of the current state
    Thomas Kristiansen
    Norwegian Air Ambulance Foundation, Department of Research, Drøbak, Norway
    Injury 41:444-52. 2010
    ..It has been suggested that Scandinavian trauma system development is immature compared to that of other regions. We wanted to assess the current status of Scandinavian trauma management and system development...
  58. ncbi Results of the CONTROL trial: efficacy and safety of recombinant activated Factor VII in the management of refractory traumatic hemorrhage
    Carl J Hauser
    Department of Surgery, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts 02216, USA
    J Trauma 69:489-500. 2010
    ..Traumatic coagulopathy contributes to early death by exsanguination and late death in multiple organ failure. Recombinant Factor VIIa (rFVIIa, NovoSeven) is a procoagulant that might limit bleeding and improve trauma outcomes...
  59. ncbi Prevalence, circumstances and consequences of falls among community-dwelling older people: results of the 2009 NSW Falls Prevention Baseline Survey
    Andrew J Milat
    The Sax Institute, Australia
    N S W Public Health Bull 22:43-8. 2011
    ..To describe the prevalence, circumstances and consequences of falls among community-dwelling older people in NSW using data from the 2009 NSW Falls Prevention Baseline Survey...
  60. pmc A dynamic view of trauma/hemorrhage-induced inflammation in mice: principal drivers and networks
    Qi Mi
    Department of Sports Medicine and Nutrition, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 6:e19424. 2011
    ..We utilized multiplexing cytokine analysis coupled with data-driven modeling to gain a systems perspective into T/HS...
  61. pmc Revised trauma scoring system to predict in-hospital mortality in the emergency department: Glasgow Coma Scale, Age, and Systolic Blood Pressure score
    Yutaka Kondo
    Department of Emergency Medicine, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Crit Care 15:R191. 2011
    ....
  62. ncbi Long-term bone marrow culture and its clinical potential in chronic wound healing
    Evangelos V Badiavas
    Roger Williams Medical Center, Department of Pathology, Providence, Rhode Island 02098, USA
    Wound Repair Regen 15:856-65. 2007
    ..Administration of improved culture cells to patients with chronic wounds present for >1 year lead to an enhanced clinical response...
  63. pmc Predicting early death in patients with traumatic bleeding: development and validation of prognostic model
    Pablo Perel
    Clinical Trials Unit, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    BMJ 345:e5166. 2012
    ..To develop and validate a prognostic model for early death in patients with traumatic bleeding...
  64. pmc Avoidable mortality from giving tranexamic acid to bleeding trauma patients: an estimation based on WHO mortality data, a systematic literature review and data from the CRASH-2 trial
    Katharine Ker
    Clinical Trials Unit, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    BMC Emerg Med 12:3. 2012
    ..Based on data from the CRASH-2 trial, global mortality data and a systematic literature review, we estimated the number of premature deaths that might be averted every year worldwide through the use of TXA...
  65. pmc The KAP evaluation of intervention on fall-induced injuries among elders in a safe community in Shanghai, China
    Ling Ling Zhang
    Key Laboratory of Public Health Safety, School of Public Health, Ministry of Education, Fudan University, Shanghai, China
    PLoS ONE 7:e32848. 2012
    ..To evaluate the effect of an intervention on fall induced injuries of elderly people in a safe-community in Shanghai and to discuss an intervention model that is proper for the community to generalize...
  66. pmc Prevalence and predictors of sub-acute phase disability after injury among hospitalised and non-hospitalised groups: a longitudinal cohort study
    Sarah Derrett
    Injury Prevention Research Unit, Department of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    PLoS ONE 7:e44909. 2012
    ..To date, few studies have investigated outcomes for both those who were hospitalised and those who were not...
  67. ncbi Report of maltreatment as a risk factor for injury death: a prospective birth cohort study
    Emily Putnam-Hornstein
    Center for Social Services Research, University of California, Berkeley, USA
    Child Maltreat 16:163-74. 2011
    ..39, 7.81]) and died from unintentional injuries at twice the rate of unreported children (95% CI [1.71, 2.36]). A prior allegation to CPS proved to be the strongest independent risk factor for injury mortality before the age of five...
  68. pmc Protective effect of tropisetron on rodent hepatic injury after trauma-hemorrhagic shock through P38 MAPK-dependent hemeoxygenase-1 expression
    Fu Chao Liu
    Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    PLoS ONE 7:e53203. 2012
    ..These results suggest that the protective effect of tropisetron administration on alleviation of hepatic injury after trauma-hemorrhage is likely mediated through p38 MAPK-dependent HO-1 expression...
  69. pmc Trauma-associated lung injury differs clinically and biologically from acute lung injury due to other clinical disorders
    Carolyn S Calfee
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
    Crit Care Med 35:2243-50. 2007
    ....
  70. pmc Prognostic models for the early care of trauma patients: a systematic review
    Marius Rehn
    Department of Research, Norwegian Air Ambulance Foundation, Drøbak, Norway
    Scand J Trauma Resusc Emerg Med 19:17. 2011
    ..Early identification of major trauma may contribute to timely emergency care and rapid transport to an appropriate health-care facility. Several prognostic trauma models have been developed to improve early clinical decision-making...
  71. ncbi Trauma mortality in mature trauma systems: are we doing better? An analysis of trauma mortality patterns, 1997-2008
    Richard P Dutton
    Program in Trauma, University of Maryland School of Medicine, Baltimore, Maryland, USA
    J Trauma 69:620-6. 2010
    ..We examined injury severity, mortality, and preventability in a mature trauma system during a 12-year period to assess the overall benefits of these and other improvements...
  72. ncbi Vital signs and estimated blood loss in patients with major trauma: testing the validity of the ATLS classification of hypovolaemic shock
    H R Guly
    Derriford Hospital, Plymouth PL6 8DH, UK
    Resuscitation 82:556-9. 2011
    ..The Advanced Trauma Life Support (ATLS) system classifies the severity of shock. The aim of this study is to test the validity of this classification...
  73. pmc Dissecting inflammatory complications in critically injured patients by within-patient gene expression changes: a longitudinal clinical genomics study
    Keyur H Desai
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America
    PLoS Med 8:e1001093. 2011
    ..New approaches are therefore needed to improve our ability to diagnose and treat this clinical condition...
  74. ncbi Unintentional injury deaths among children younger than 5 years of age in India: a nationally representative study
    Jagnoor Jagnoor
    Centre for Global Health Research, Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Canada
    Inj Prev 17:151-5. 2011
    ..To determine the mortality burden associated with unintentional injuries among children younger than 5 years of age in India...
  75. ncbi Predefined massive transfusion protocols are associated with a reduction in organ failure and postinjury complications
    Bryan A Cotton
    Department of Surgery, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    J Trauma 66:41-8; discussion 48-9. 2009
    ..The purpose of this study was to determine whether MT protocols are associated with increased organ failure and complications...
  76. ncbi National five-year examination of inequalities and trends in emergency hospital admission for violence across England
    Mark A Bellis
    Centre for Public Health, Liverpool John Moores University, Henry Cotton Campus, 15 21 Webster Street, Liverpool, UK
    Inj Prev 17:319-25. 2011
    ..To examine relationships between violence, age (0-74 years), and deprivation, and to explore in which communities, age groups, and gender the potential for transmission of violent tendencies between individuals is greatest...
  77. ncbi The New Injury Severity Score: a more accurate predictor of in-hospital mortality than the Injury Severity Score
    Andre Lavoie
    Centre Hospitalier Affilie Universitaire De Quebec, Enfant Jésus Hospital, Quebec City, Quebec, Canada
    J Trauma 56:1312-20. 2004
    ....
  78. ncbi Epidemiology of combat wounds in Operation Iraqi Freedom and Operation Enduring Freedom: orthopaedic burden of disease
    Philip J Belmont
    Associate Professor, USUHS, Orthopaedic Surgery Service, William Beaumont Army Medical Center Texas Tech University Health Sciences Center, 5005 N Piedras, El Paso, TX 79920, USA
    J Surg Orthop Adv 19:2-7. 2010
    ..Collection and careful examination of orthopaedic combat casualties will allow for improved military personnel protective measures and treatment of injured soldiers...
  79. ncbi AIS 2005: a contemporary injury scale
    Thomas A Gennarelli
    Department of Neurosurgery, Medical College of Wisconsin, 9200 W, Wisconsin Avenue, Milwaukee, WI 53226, United States
    Injury 37:1083-91. 2006
    ..In addition to a universal injury language, it provides measures of injury severity that can be used to stratify and classify injury severity in all body regions. Its revision, AIS 2005 will be discussed here...
  80. ncbi Determinants of return to work following non life threatening acute orthopaedic trauma: a prospective cohort study
    Fiona J Clay
    Monash University, Accident Research Centre Building 70, Clayton Victoria, 3800, Australia
    J Rehabil Med 42:162-9. 2010
    ..To determine factors associated with return to work following acute non-life-threatening orthopaedic trauma...
  81. ncbi Psychological distress after severe trauma: a prospective 1-year follow-up study of a trauma intensive care unit population
    Kirsti Tøien
    Intensive Care Unit, Oslo University Hospital, Ulleval, Oslo, Norway
    J Trauma 69:1552-9. 2010
    ..The aim of the study was to investigate the level of psychologic distress after trauma and intensive care unit (ICU) stay, memory from the ICU, and predictors for psychologic distress at 12 months...
  82. ncbi Oxygen in wound healing--more than a nutrient
    Andrea A Tandara
    Wound Healing Research Laboratory, Northwestern University, 303 East Chicago Avenue, Tarry Bldg 4 720, Chicago, IL 60611, USA
    World J Surg 28:294-300. 2004
    ..The article concludes with a discussion of why hypoxia and hyperoxia intercurrently play an important role in wound healing. Hypoxia-inducible factor 1 is crucial in that interplay...
  83. ncbi Wound-induced assembly and closure of an actomyosin purse string in Xenopus oocytes
    W M Bement
    Department of Zoology, Program in Cellular and Molecular Biology, University of Wisconsin Madison, 1117 West Johnson Street, Madison, Wisconsin 53706, USA
    Curr Biol 9:579-87. 1999
    ....
  84. ncbi A role for endogenous electric fields in wound healing
    Richard Nuccitelli
    RPN Research 144, Carroll St, New Britain, CT 06053, USA
    Curr Top Dev Biol 58:1-26. 2003
    ..However, these trials have utilized many different field strengths and polarities, so much work is needed to optimize this approach for the treatment of mammalian wounds...
  85. ncbi Violence and injuries in Brazil: the effect, progress made, and challenges ahead
    Michael Eduardo Reichenheim
    Department of Epidemiology, Institute of Social Medicine, Rio de Janeiro State University, Rio de Janeiro, RJ, Brazil
    Lancet 377:1962-75. 2011
    ..The main challenge is to assess these advances to identify, extend, integrate, and continue the successful ones...
  86. ncbi Epidemiology of traumatic deaths: comprehensive population-based assessment
    Julie A Evans
    Department of Traumatology, Division of Surgery, John Hunter Hospital and University of Newcastle, Hunter Region Mail Centre, Newcastle, NSW 2310, Australia
    World J Surg 34:158-63. 2010
    ....
  87. pmc Deaths from injury in children and employment status in family: analysis of trends in class specific death rates
    Phil Edwards
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT
    BMJ 333:119. 2006
    ..To examine socioeconomic inequalities in rates of death from injury in children in England and Wales...
  88. pmc Post-conflict mental health needs: a cross-sectional survey of trauma, depression and associated factors in Juba, Southern Sudan
    Bayard Roberts
    Conflict and Health Programme, Health Policy Unit, Department of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, UK
    BMC Psychiatry 9:7. 2009
    ....
  89. pmc The epidemiology and modern management of traumatic hemorrhage: US and international perspectives
    David S Kauvar
    United States Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    Crit Care 9:S1-9. 2005
    ..We conclude with a discussion of outcome measures for the injured patient within the context of the epidemiology of traumatic injury...
  90. ncbi Body mass index and injury risk among US children 9-15 years old in motor vehicle crashes
    K M Pollack
    Department of Health Policy and Management, Center for Injury Research and Policy, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Inj Prev 14:366-71. 2008
    ..To determine the relationship between body mass index (BMI) and injury risk among US children in motor vehicle crashes...
  91. ncbi Multiple risk behavior and injury: an international analysis of young people
    William Pickett
    Department of Community Health and Epidemiology, Queen s University, Kingston, Ontario, Canada K7L 2V7
    Arch Pediatr Adolesc Med 156:786-93. 2002
    ..Multiple risk behavior plays an important role in the social etiology of youth injury, yet the consistency of this observation has not been examined multinationally...
  92. ncbi Wound therapy by marrow mesenchymal cell transplantation
    Takafumi Yoshikawa
    Department of Orthopedic Surgery, Nara Medical University, Japan
    Plast Reconstr Surg 121:860-77. 2008
    ..This new treatment was useful for tissue regeneration in 20 patients with skin wounds...
  93. pmc Topical delivery of mesenchymal stem cells and their function in wounds
    J Michael Sorrell
    Department of Biology, Skeletal Research Center, Case Western Reserve University, 2080 Adelbert Road, Cleveland, OH 44106, USA
    Stem Cell Res Ther 1:30. 2010
    ....
  94. pmc Societal values and policies may curtail preschool children's physical activity in child care centers
    Kristen A Copeland
    Division of General and Community Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Pediatrics 129:265-74. 2012
    ..Children are primarily sedentary in these settings, and are not meeting recommended levels of physical activity. Our objective was to identify potential barriers to children's physical activity in child care centers...
  95. ncbi Falls in the general hospital: association with delirium, advanced age, and specific surgical procedures
    Barbara E Lakatos
    Dept of Nursing, Brigham and Women s Hospital, 75 Francis St, Tower 14, Boston, MA 02115, USA
    Psychosomatics 50:218-26. 2009
    ..Falls and delirium in general-hospital inpatients are related to increases in morbidity, mortality, and healthcare costs. Patients fall despite safeguards and programs to reduce falling...
  96. ncbi Cost estimation of injury-related hospital admissions in 10 European countries
    Suzanne Polinder
    Department of Public Health, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands
    J Trauma 59:1283-90; discussion 1290-1. 2005
    ..Injuries are a major cause of total health care costs. Cost estimations may help identify injuries and high risk-groups to be considered for potential intervention...
  97. pmc Measuring the population burden of injuries--implications for global and national estimates: a multi-centre prospective UK longitudinal study
    Ronan A Lyons
    Centre for Health Information Research and Evaluation, College of Medicine, Swansea University, UK
    PLoS Med 8:e1001140. 2011
    ..The aim of this study was to compare the population burden of injuries using different approaches from the UK Burden of Injury (UKBOI) and GBD studies...
  98. ncbi The role of supervision in child injury risk: definition, conceptual and measurement issues
    Gitanjali Saluja
    National Institute for Child Health and Human Development, National Institutes for Health, U S Department of Health and Human Services, Bethesda, MD 20892 7510, USA
    Inj Control Saf Promot 11:17-22. 2004
    ..The framework includes family and community characteristics and policies/regulations that may be important in caregiver decisions to use active or passive injury prevention strategies. Future research directions are discussed...
  99. ncbi Prospective Outcomes of Injury Study: recruitment, and participant characteristics, health and disability status
    Sarah Derrett
    Department of Preventive and Social Medicine, Injury Prevention Research Unit, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Inj Prev 17:415-8. 2011
    ..Analysis of outcome predictors related to post-injury function, disability and return-to-work soon after injury and 1 year later is now under way...
  100. ncbi Initial urinary epinephrine and cortisol levels predict acute PTSD symptoms in child trauma victims
    Douglas L Delahanty
    Department of Psychology, Kent State University, 118 Kent Hall, Kent, OH 44242, USA
    Psychoneuroendocrinology 30:121-8. 2005
    ..The present study extended these findings by examining whether urinary hormone levels collected soon after a trauma were related to subsequent acute PTSD symptoms in child trauma victims...
  101. ncbi Helicopters and the civilian trauma system: national utilization patterns demonstrate improved outcomes after traumatic injury
    Joshua B Brown
    Department of Surgery, University of Rochester School of Medicine, Rochester, New York 14642 8410, USA
    J Trauma 69:1030-4; discussion 1034-6. 2010
    ..The objective of this study was to compare patient outcomes after transport from the scene of injury by HT and ground transport using a national patient sample...

Research Grants87

  1. Nitric Oxide Releasing Topical Gel for Burn Wound Healing
    ANJAL SHARMA; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  2. Sutureless Laparoscopic Partial Nephrectomy Using Laser Tissue Welding: Preclinic
    Yasmin Wadia; Fiscal Year: 2013
    ..Fibro-optic capable: Minimally invasive laparoscopic &robotic applications. ..
  3. Ligand Directed Transdermal siRNA Delivery to Improve Wound Healing
    David M Evans; Fiscal Year: 2012
    ..The outcome of this project will be the initial characterization of a valuable therapeutic option for treatment of patients with various types of skin wounds. ..
  4. Photodynamic Therapy of Localized Infections
    Michael R Hamblin; Fiscal Year: 2013
    ....
  5. Epithelial differentiation in cornea
    Bogi Andersen; Fiscal Year: 2012
    ....
  6. Somatic Stem Cells in Engineered Human Skin
    Steven Boyce; Fiscal Year: 2009
    ....
  7. Inhibitors of isoprenoid synthesis for antibacterial therapy
    Donald T Moir; Fiscal Year: 2013
    ..In Phase II, we will examine analogs of the highest priority hits and chemically optimize the most promising of these structures to develop lead compounds for efficacy and toxicity testing in animal models. ..
  8. Role of Stat3 in Breast Cancer Tumorigenesis
    Jacqueline F Bromberg; Fiscal Year: 2010
    ....
  9. MicroRNA Regulation of Macrophage Polarization in Muscle Regeneration
    Paula K Shireman; Fiscal Year: 2013
    ....
  10. Role of AIB1 in malignant progression
    Anna Tate Riegel; Fiscal Year: 2013
    ..Identification of novel pathways can be used to understand drivers of malignant progression and design novel therapeutic strategies. ..
  11. Surgical Wound Repair: Role of A Neuroendothelial Axis
    NICOLE SIMONE GIBRAN; Fiscal Year: 2010
    ..We will employ siRNA to deplete neuropeptide receptors on endothelial cells to further define neural modulation of endothelial cell inflammatory responses, migration and proliferation. ..
  12. Biofilm matrix-degrading enzymes for the treatment and prevention of S. aureus-as
    Jeffrey B Kaplan; Fiscal Year: 2013
    ..If successful, these slime-degrading enzymes will be incorporated into a topical ointment that can be used to treat and prevent wound infections in people. ..
  13. Skin Regeneration with Stem Cells and Scaffolds
    SUSAN RENEE OPALENIK; Fiscal Year: 2013
    ..abstract_text> ..
  14. Improve Wound Healing with HIF-CA5 DNA Vector and Electroporation
    John W Harmon; Fiscal Year: 2010
    ..Building on the promising pre- clinical data generated to date, the objective of the proposed STTR program is to bring the CA5 product candidate into clinical testing. ..
  15. Regenerative Adjuvant Therapy for Stress Urinary Incontinence
    Margot S Damaser; Fiscal Year: 2011
    ..Specific projects to test stem cell homing as a possible adjuvant to rehabilitative treatments after polytrauma will be developed based on the outcome of the proposed work. ..
  16. Distinct roles of CARP target genes in wound healing
    Karinna Almodóvar; Fiscal Year: 2013
    ..Results derived from this study can lead to the delineation of new mechanisms that regulate wound angiogenesis. ..
  17. Protein Therapy for Recessive Dystrophic Epidermolysis Bullosa
    David T Woodley; Fiscal Year: 2010
    ..The proposed studies will facilitate future development of protein- based therapy for other inherited skin diseases. ..
  18. Intra-operative confocal imaging to guide Mohs surgery
    Milind Rajadhyaksha; Fiscal Year: 2012
    ..Confocal microscopy may also prove useful for noninvasively diagnosing and treating many other types of cancers such as oral, head-and-neck, breast and cervical. ..
  19. Development of Adult Pluripotent Very Small Embryonic Like (VSEL) Stem Cells to T
    DENIS OVEREND RODGERSON; Fiscal Year: 2013
    ....
  20. Mechanisms and translation of lipid resuscitation
    Guy L Weinberg; Fiscal Year: 2013
    ..Improved patient safety and outcomes from drug toxicity are the over-arching goals of this project. ..
  21. Boosting Innate Immunity Through HIF to Treat Antibiotic-Resistant Infections
    ROBERT ALAN SHALWITZ; Fiscal Year: 2013
    ..Ultimately, HIF-1 immune boosting therapy could find wide application in the treatment of difficult infections complicated by antibiotic resistance or weakened host defense. ..
  22. Innovative technologies to effectively treat Multi-drug resistant and/or biofilm-
    Jie Wen; Fiscal Year: 2010
    ..By 2007, the US wound care market has grown to an estimated $10 B. This growth has driven efforts to reduce infection that resulted in the development of antimicrobial dressings. ..
  23. Development of a Topical Choroid Plexus Factor Product to Accelerate Wound Healin
    CHRISTOPHER GORDON THANOS; Fiscal Year: 2011
    ....
  24. Development of Cytokine-Inhibiting Gels for Treating Chronic Wounds
    Newell R Washburn; Fiscal Year: 2010
    ..Washburn Therapeutics Inc. is developing a novel gel that inhibits the fundamental biochemical factors that sustain non-healing wounds and promotes healing. ..
  25. Development of Extracellular Heat Shock Protein-90 as a Novel Topical Wound Heali
    Wei Li; Fiscal Year: 2013
    ..Our goal is to develop a recombinant Hsp90a peptide into a novel and more effective wound-healing agent. ..
  26. REDUCING LAPAROTOMY WOUND FAILURE
    Sufan Chien; Fiscal Year: 2013
    ..The success of this product will benefit millions of patients who undergo abdominal surgery each year. The usage of this technique may be expanded to other surgical repair procedures and acute wounds. The potential impact is high. ..
  27. A NEW TECHNIQUE FOR TREATING HEMORRHAGIC SHOCK
    Sufan Chien; Fiscal Year: 2013
    ..The potential impact on medicine is high. ..
  28. Aminoglycoside potentiators for P. aeruginosa therapy
    Donald T Moir; Fiscal Year: 2013
    ..In Phase II, we will develop the most promising validated hits into lead compounds by optimizing their activity and specificity and evaluate them for efficacy and toxicity in animal models of infection. ..
  29. Augmentation of Innate Anti-Microbial Immunity by TLR4 Agonists
    Edward R Sherwood; Fiscal Year: 2013
    ....
  30. CAP37 and ocular inflammation
    HELOISE ANNE PEREIRA; Fiscal Year: 2011
    ..We believe our findings will help develop new therapies for treating wounds and infections of the eye based on the biological molecule CAP37 and its bioactive peptides. ..
  31. Mission Reconnect: Promoting Resilience and Reintegration of Post-Deployment Vete
    Janet Kahn; Fiscal Year: 2013
    ..Product. Mission Reconnect is an integrated multimedia program deliverable over the Internet and mobile devices, and hard copy (DVD, CD, manual). ..
  32. A novel therapeutic approach for pressure ulcers
    EDWARD PAUL MONAGHAN; Fiscal Year: 2012
    ..Here, we propose to lay the groundwork needed to translate this research finding into a clinically useful treatment for bed sores in the elderly. ..
  33. Mesenchymal Stem Cells To Mitigate and Treat Cutaneous Injury Following Radiation
    William H McBride; Fiscal Year: 2010
    ..To cover wide areas of radiation-induced burns, we will add MSCs on FMBs to natural collagen sheets as a form of biological dressing. ..
  34. microRNA Control of Wound Healing
    Chandan K Sen; Fiscal Year: 2013
    ..This light originates from recent breakthrough discoveries recognizing a novel class of genes - previously thought to be junk - called microRNAs as being of critical significance in health and disease. ..
  35. Skin Stem Cells: Purification and Characterization
    Elaine Fuchs; Fiscal Year: 2013
    ..This study is a fundamental prerequisite to ascertaining the potential of skin stem cells for regenerative therapies that go beyond burn treatments. ..
  36. Transdermal Delivery of Deferoxamine to Prevent and Treat Diabetic Wounds
    Geoffrey C Gurtner; Fiscal Year: 2011
    ....
  37. Reducing wound bioburden and biofilm formation using a nanoscale wound surface en
    Jonathan F McAnulty; Fiscal Year: 2013
    ....
  38. Mechanisms of Human Dermal Fibroblast Migration
    Wei Li; Fiscal Year: 2013
    ....
  39. MECHANISMS OF ARP2/3 ACTIVATION AND FUNCTION
    R Dyche Mullins; Fiscal Year: 2013
    ..The goal of this proposal is to understand the key molecular mechanisms underlying cell migration. ..
  40. Tissue Oxygenation and Wound Healing
    Chandan K Sen; Fiscal Year: 2013
    ..We propose a prospective longitudinal study where adult non-diabetic patients with chronic leg ulcers visiting the OSU Comprehensive Wound Center will be enrolled. ..
  41. Individual Predoctoral Dental Scientist Fellowship
    MELISSA ANNE TALBERT; Fiscal Year: 2011
    ..The goal of this study is to improve implant biocompatibility with host tissue by elucidating the role of mesenchymal stem cells in TGF-?[unreadable] dependent fibrous tissue formation. ..
  42. MiR-1 is a Critical Regulator of VEGF-Induced Angiogenesis
    Seyedtaghi Takyar; Fiscal Year: 2013
    ..of blood vessels anywhere in the body, and this process is crucial for normal development and healing of wounds and injuries. However, if this process becomes excessive it can cause chronic bleeding and a non-healing wound...
  43. Micro-RNA Molecules as Regulators of Diabetic Wound Healing
    Marjana Tomic-Canic; Fiscal Year: 2013
    ..Successful completion of this project will lead to future studies to develop candidate therapeutics through preclinical and clinical testing. ..
  44. MiR-1 is a Critical Regulator of VEGF-Induced Angiogenesis
    Seyedtaghi Takyar; Fiscal Year: 2012
    ..of blood vessels anywhere in the body, and this process is crucial for normal development and healing of wounds and injuries. However, if this process becomes excessive it can cause chronic bleeding and a non-healing wound...
  45. Adipose-Derived Stromal/Stem Cell Therapy for Pressure Ulcers
    Xiying Wu; Fiscal Year: 2012
    ..S. and abroad. With its background in adipose stromal/stem cell biotechnology, LaCell and its consultants are uniquely positioned to address this unmet medical need. ..
  46. Mechanisms of Impaired Wound Healing Due to Ischemia
    Lisa J Gould; Fiscal Year: 2012
    ..The molecular changes that occur in wound healing, particularly in the elderly who more commonly have tissue ischemia, are poorly understood. ..
  47. siRNA-gold nanoparticle mediated ganglioside depletion for diabetic wound healing
    AMY SUSAN PALLER; Fiscal Year: 2013
    ..These studies promise to have great impact in the treatment of wounds in humans, particularly in individuals with insulin-resistant diabetes. ..
  48. Regulation of human skin homeostasis by histone arginine methylation regulators
    Xiaomin Bao; Fiscal Year: 2013
    ....
  49. Novel Formulation of Topical Losartan for Treatment of Wounds in Aging
    JEREMY DAVID WALSTON; Fiscal Year: 2013
    ..Such results will facilitate the rapid translation of these findings into human subjects, and have great potential to rapidly shift the present wound healing care paradigm in older adults. ..
  50. Cutaneous wound remodeling by re-differentiating keratinocytes expressing CXCR3 l
    ARTHUR HUEN; Fiscal Year: 2013
    ..Understanding the control of these signals may lead to better ways to treat chronic wounds and to more rapidly restore skin function and appearance after trauma. ..
  51. Identification of a novel population in the adult bone marrow
    Ernestina Schipani; Fiscal Year: 2012
    ..The accomplishment of the experiments described in Aims I and II will likely expand our knowledge on the pathogenesis of bone marrow fibrosis, at least in a context of chronic activation of the PTH receptor. ..
  52. Corneal Stromal-Epithelial Interactions During Fibrosis and Regeneration
    James D Zieske; Fiscal Year: 2012
    ....
  53. Epigenetic misregulation of immune responses after alcohol exposure and injury
    BRENDA JEAN CURTIS; Fiscal Year: 2012
    ..abstract_text> ..
  54. TeleWellness Solutions for Chronic Conditions
    EDMUND FRANK LOPRESTI; Fiscal Year: 2013
    ..Phase II goals will be to ensure that the system is secure and robust for real-world, high-volume deployment;and to evaluate clinical efficacy of the final system. ..
  55. Sex-specific Regulation of Acute Inflammation and Resolution
    Karsten Gronert; Fiscal Year: 2013
    ..Hence, results from this study could rapidly bring novel treatment options for ocular surface inflammatory diseases to the clinic. ! ..
  56. Nitric Oxide-Releasing Wound Dressing for Preventing Chronic Wound Infections
    NATHAN ALLAN STASKO; Fiscal Year: 2012
    ..The Company has assembled a strong team of scientists, clinicians, contractors, and business leaders who believe in the technology and are positioned to ensure the greatest likelihood for success. ..
  57. Matrix Metalloproteinase Regulation of Leukocyte Infiltration during Wound Repair
    LISA JOY MCCAWLEY; Fiscal Year: 2013
    ..An essential part of wound healing is inflammation. Matrix Metalloproteinases such as MMP3 may play a key role in regulating inflammation during wound healing. ..
  58. Gene Transfer for Recessive Dystrophic Epidermolysis Bullosa
    MATT PETER MARINKOVICH; Fiscal Year: 2013
    ..We plan to correct the affected person's own skin cells and transplant their own cells back onto their skin. Effective gene therapy in this skin disease will assist in development of gene therapy for other genetic diseases. ..
  59. Profiling human reactive astrocytes for neurotrauma biomarkers
    Ina Beate Wanner; Fiscal Year: 2012
    ....
  60. NorLeu3-A(1-7): Enhanced Recovery of Radiation Burns
    Kathleen E Rodgers; Fiscal Year: 2010
    ....
  61. A collagen wound dressing augmented with a proteoglycan mimic to enhance chronic
    Kate Stuart; Fiscal Year: 2013
    ..GMP synthesis, biocompatibility testing, and a small clinical safety study will be the milestones for a Phase II award. ..
  62. Development of lisinopril for post-exposure mitigation of late effects from a rad
    MEETHA M MEDHORA; Fiscal Year: 2013
    ..We have organized an efficient as well as responsive research plan, team of experts and well trained personnel to meet our goals. ..
  63. Targeting myofibroblast activation in chronic fibrotic disease
    ARTHUR ROGER STRAUCH; Fiscal Year: 2011
    ..abstract_text> ..
  64. Development of the Cellular Biomarker for Diabetic Foot Ulcers
    MARJANA contact TOMIC CANIC; Fiscal Year: 2010
    ....
  65. Multivalent Conjugates of Sonic Hedgehog to Accelerate Diabetic Wound Healing
    WESLEY MICHAEL JACKSON; Fiscal Year: 2012
    ..The overall goal of our Phase I project is to relate the treatment parameters of our therapeutic to the cellular mechanism of blood vessel formation and demonstrate proof-of-concept for our technology as a clinical therapy. ..
  66. Contractile Hydrogel Dressing for Primary Wound Closure
    Aristidis Veves; Fiscal Year: 2010
    ....
  67. Stimuli Responsive Topical Gels for Mechanically Assisted Wound Debridement
    Aristidis Veves; Fiscal Year: 2010
    ....
  68. DIABETIC NEUROPATHIC FOOT ULCER: WHO WILL HEAL?
    David Margolis; Fiscal Year: 2003
    ..These models will not only be useful to health care providers, but they will also be useful to clinical investigators trying to design clinical trials on patients that might maximally benefit from a new treatment. ..
  69. TESTING A DECISION AID FOR THE MANAGEMENT OF INJURIES
    John Clarke; Fiscal Year: 1993
    ....
  70. Enhanced Cryoprecipiate in Wound Healing
    Edward Shanbrom; Fiscal Year: 2007
    ..The ultimate goal is to translate this product into clinical use for treating patients with extensive wound and burns by evaluating the use of enhanced cryoprecipitate in Phase II studies. [unreadable] [unreadable] [unreadable]..
  71. Growth factor delivery patch for wound healing
    Fen Zhang; Fiscal Year: 2005
    ..While the technology is targeted for the treatment of chronic wounds, it may also be useful for the treatment of many skin diseases, for treatment of burns, and for treatment of eye diseases. ..
  72. ETIOLOGY AND CONTROL OF POSTBURN HYPERMETABOLISM
    FRED CALDWELL; Fiscal Year: 1991
    ..e., increased evaporative and radiational heat loss, E and NE, fever, and TSet shift...
  73. Tissue Engineering by a Non-Biologic Skin Substitute
    WILLIAM SEARE; Fiscal Year: 2005
    ....
  74. Evaluation of a novel connexin-based peptide for the treatment of diabetic wounds
    Gautam Ghatnekar; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  75. Topical negative pressure dressings for the prevention of chronic wound biofilm
    GUY ORGAMBIDE; Fiscal Year: 2009
    ..The impact of the proposed product concept on patients, physicians and the state of care would promote enhanced quality of life and potentially a reduction in extended medical care precipitated by complicated wounds. ..
  76. NEW HOMEBOX GENES IN SCARLESS FETAL WOUND HEALING
    Corey Largman; Fiscal Year: 2001
    ..They hope these data will, in the long term, permit a type of scarless wound healing in adult tissue. ..
  77. Diabetic Foot and Pressure Ulcer Databank
    Harold Brem; Fiscal Year: 2009
    ..abstract_text> ..
  78. REACTIVE ASTROGLIA--INFLUENCES ON CNS GRAFTS AND WOUNDS
    JANETTE KRUM; Fiscal Year: 2002
    ....
  79. Bone marrow-derived fibroblasts in skin wound healing
    Omaida C Velazquez; Fiscal Year: 2010
    ..abstract_text> ..
  80. Innovative intervention for healing of diabetic ulcers
    Joyce Stechmiller; Fiscal Year: 2005
    ..Data will be analyzed using multivariate methods. Translating advances in the bio molecular and genetic basis of diabetes and diabetic wound healing is needed to improve nursing care and quality of life. ..
  81. Circumferential Neuropathic Foot Protector System (CNEP)
    Jeffrey Jensen; Fiscal Year: 2001
    ....
  82. A Shear Force Transfer Coupling for Soft Tissue Repair
    MARK BYRNE; Fiscal Year: 2003
    ..abstract_text> ..
  83. Role of mechanical strain in incisional hernia fibroblast function.
    ERIC J CULBERTSON; Fiscal Year: 2010
    ....
  84. A NETWORK OF RESEARCH UNITS TO STUDY CLINICAL WOUND CARE
    James Quinn; Fiscal Year: 2004
    ..In this study amoxicillin/clavulanic acid will be compared to placebo. The primary outcome of the study will be infection. Other outcomes studied will be wound-healing patient satisfaction and cost. ..
  85. Diagnostic Tool for the Point-of-Care Detection of Infection in Chronic Wounds
    MITCHELL SANDERS; Fiscal Year: 2009
    ..Earlier and more accurate infection diagnosis will allow patients to receive the appropriate treatment sooner, resulting in less pain and suffering and a lower risk of serious infection-related complications. ..
  86. Targeted Oxygen Delivery to Wounds: Using a Novel, Tunable, Oxygen Delivery Tech
    STEPHEN CARY; Fiscal Year: 2010
    ..The ability to apply protein to wounds and enhance wound healing will have a significant therapeutic impact for the millions of patients who suffer chronic, slow healing wounds. ..
  87. Angiogenic Peptide Scaffolds to Enhance Diabetic Wound Healing
    DARIA NARMONEVA; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE:This study is focused on application of novel materials peptide nanoscaffolds- to restore angiogenic environment in the wound bed and enhance diabetic wound healing. ..