tobacco use disorder

Summary

Summary: Tobacco used to the detriment of a person's health or social functioning. Tobacco dependence is included.

Top Publications

  1. ncbi A variant associated with nicotine dependence, lung cancer and peripheral arterial disease
    Thorgeir E Thorgeirsson
    deCODE Genetics, 101 Reykjavik, Iceland
    Nature 452:638-42. 2008
  2. pmc Habenular α5 nicotinic receptor subunit signalling controls nicotine intake
    Christie D Fowler
    Laboratory for Behavioral and Molecular Neuroscience, Department of Molecular Therapeutics, The Scripps Research Institute Scripps Florida, Jupiter, Florida 33458, USA
    Nature 471:597-601. 2011
  3. pmc The role of engagement in a tailored web-based smoking cessation program: randomized controlled trial
    Victor J Strecher
    Center for Health Communications Research, University of Michigan School of Public Health, Ann Arbor, MI 48109 0471, USA
    J Med Internet Res 10:e36. 2008
  4. pmc Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior
    Thorgeir E Thorgeirsson
    1 deCODE genetics, Reykjavik, Iceland 2 Center for Biomolecular Science and Engineering, Jack Baskin School of Engineering, University of California, Santa Cruz, California, USA
    Nat Genet 42:448-53. 2010
  5. pmc Variants in nicotinic receptors and risk for nicotine dependence
    Laura Jean Bierut
    Department of Psychiatry, Washington University School of Medicine, Box 8134, 660 South Euclid Ave, St Louis, MO 63110, USA
    Am J Psychiatry 165:1163-71. 2008
  6. pmc Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs
    Scott F Saccone
    Department of Psychiatry, Box 8134, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Hum Mol Genet 16:36-49. 2007
  7. ncbi Nicotine dependence and psychiatric disorders in the United States: results from the national epidemiologic survey on alcohol and related conditions
    Bridget F Grant
    Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
    Arch Gen Psychiatry 61:1107-15. 2004
  8. pmc The CHRNA5-A3 region on chromosome 15q24-25.1 is a risk factor both for nicotine dependence and for lung cancer
    Margaret R Spitz
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77230 1439, USA
    J Natl Cancer Inst 100:1552-6. 2008
  9. pmc The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans
    Nancy L Saccone
    Department of Genetics, Washington University, St Louis, Missouri 63110, UA
    Cancer Res 69:6848-56. 2009
  10. pmc Initial evaluation of a real-world Internet smoking cessation system
    Nathan K Cobb
    Beth Israel Deaconess Medical Center Harvard University School of Medicine, Boston, MA, USA
    Nicotine Tob Res 7:207-16. 2005

Research Grants

Detail Information

Publications299 found, 100 shown here

  1. ncbi A variant associated with nicotine dependence, lung cancer and peripheral arterial disease
    Thorgeir E Thorgeirsson
    deCODE Genetics, 101 Reykjavik, Iceland
    Nature 452:638-42. 2008
    ..The findings provide a case study of a gene-environment interaction, highlighting the role of nicotine addiction in the pathology of other serious diseases...
  2. pmc Habenular α5 nicotinic receptor subunit signalling controls nicotine intake
    Christie D Fowler
    Laboratory for Behavioral and Molecular Neuroscience, Department of Molecular Therapeutics, The Scripps Research Institute Scripps Florida, Jupiter, Florida 33458, USA
    Nature 471:597-601. 2011
    ..Our findings indicate that nicotine activates the habenulo-interpeduncular pathway through α5-containing nAChRs, triggering an inhibitory motivational signal that acts to limit nicotine intake...
  3. pmc The role of engagement in a tailored web-based smoking cessation program: randomized controlled trial
    Victor J Strecher
    Center for Health Communications Research, University of Michigan School of Public Health, Ann Arbor, MI 48109 0471, USA
    J Med Internet Res 10:e36. 2008
    ..First, does engagement with program content predict long-term outcomes? Second, which users are most likely to drop out or disengage from the program? Third, do particular intervention strategies enhance engagement?..
  4. pmc Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior
    Thorgeir E Thorgeirsson
    1 deCODE genetics, Reykjavik, Iceland 2 Center for Biomolecular Science and Engineering, Jack Baskin School of Engineering, University of California, Santa Cruz, California, USA
    Nat Genet 42:448-53. 2010
    ..Nominal associations with lung cancer were observed at both 8p11 (rs6474412[T], odds ratio (OR) = 1.09, P = 0.04) and 19q13 (rs4105144[C], OR = 1.12, P = 0.0006)...
  5. pmc Variants in nicotinic receptors and risk for nicotine dependence
    Laura Jean Bierut
    Department of Psychiatry, Washington University School of Medicine, Box 8134, 660 South Euclid Ave, St Louis, MO 63110, USA
    Am J Psychiatry 165:1163-71. 2008
    ....
  6. pmc Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs
    Scott F Saccone
    Department of Psychiatry, Box 8134, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Hum Mol Genet 16:36-49. 2007
    ..Other genes among the top signals were KCNJ6 and GABRA4. This study represents one of the most powerful and extensive studies of nicotine dependence to date and has found novel risk loci that require confirmation by replication studies...
  7. ncbi Nicotine dependence and psychiatric disorders in the United States: results from the national epidemiologic survey on alcohol and related conditions
    Bridget F Grant
    Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
    Arch Gen Psychiatry 61:1107-15. 2004
    ..No information is available on the co-occurrence of DSM-IV nicotine dependence and Axis I and II psychiatric disorders in the US population...
  8. pmc The CHRNA5-A3 region on chromosome 15q24-25.1 is a risk factor both for nicotine dependence and for lung cancer
    Margaret R Spitz
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77230 1439, USA
    J Natl Cancer Inst 100:1552-6. 2008
    ..Thus, we conclude that the variants are implicated both in smoking behavior and more directly in lung cancer risk...
  9. pmc The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans
    Nancy L Saccone
    Department of Genetics, Washington University, St Louis, Missouri 63110, UA
    Cancer Res 69:6848-56. 2009
    ..The nonsynonymous SNP rs16969968, a known risk variant in populations of European-descent, is also significantly associated with risk in African-Americans. Additional SNPs contribute to risk in distinct ways in these two populations...
  10. pmc Initial evaluation of a real-world Internet smoking cessation system
    Nathan K Cobb
    Beth Israel Deaconess Medical Center Harvard University School of Medicine, Boston, MA, USA
    Nicotine Tob Res 7:207-16. 2005
    ....
  11. ncbi Nicotine, alcohol and drug dependence and psychiatric comorbidity. Results of a national household survey
    M Farrell
    National Addiction Centre, Institute of Psychiatry, King s College London, Maudsley Hospital, 4 Windsor Walk, London SE5 8AF, UK
    Br J Psychiatry 179:432-7. 2001
    ..There is a well-recognised relationship between substance use disorders and other psychiatric disorders. This relationship has been well documented in a range of population-based studies...
  12. ncbi A meta-analysis of worldwide studies demonstrates an association between schizophrenia and tobacco smoking behaviors
    Jose de Leon
    Mental Health Research Center at Eastern State Hospital, 627 West Fourth St, Lexington, KY 40508, USA
    Schizophr Res 76:135-57. 2005
    ..Thus, people who are going to develop schizophrenia have risk factors that make them more vulnerable to start smoking...
  13. ncbi Nicotine activation of alpha4* receptors: sufficient for reward, tolerance, and sensitization
    Andrew R Tapper
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Science 306:1029-32. 2004
    ..These data indicate that activation of a4* receptors is sufficient for nicotine-induced reward, tolerance, and sensitization...
  14. pmc International Spanish/English Internet smoking cessation trial yields 20% abstinence rates at 1 year
    RICARDO F MUNOZ
    Department of Psychiatry at San Francisco General Hospital, Latino Mental Health Research Program, and Internet World Health Research Center, University of California, San Francisco, San Francisco, CA 94110, USA
    Nicotine Tob Res 11:1025-34. 2009
    ..Evidence-based Internet interventions with comparable abstinence rates could be a powerful global tool to reduce tobacco-related morbidity and mortality...
  15. pmc Peer smoking and the nicotinic receptor genes: an examination of genetic and environmental risks for nicotine dependence
    Eric O Johnson
    Behavioral Health Epidemiology Program, Research Triangle Institute International, 3040 Cornwallis Road, Research Triangle Park, NC 27709 2194, USA
    Addiction 105:2014-22. 2010
    ..Here we test the hypothesis that the nicotinic receptor genes CHRNA5 (rs16969968), CHRNA3 (rs578776), CHRNB3 (rs13277254) and CHRND (rs12466358) modify the risk for nicotine dependence associated with peer smoking...
  16. pmc Addressing tobacco use disorder in smokers in early remission from alcohol dependence: the case for integrating smoking cessation services in substance use disorder treatment programs
    David Kalman
    Department of Psychiatry, University of Massachusetts School of Medicine, Worcester, MA 01655, USA
    Clin Psychol Rev 30:12-24. 2010
    ..Finally, we offer recommendations for research with an emphasis on clinical research for enhancing smoking cessation outcomes in this population...
  17. pmc Incorporating age at onset of smoking into genetic models for nicotine dependence: evidence for interaction with multiple genes
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    Addict Biol 15:346-57. 2010
    ..Incorporation of logically chosen interaction parameters, such as AOS, into genetic models of substance use disorders may increase the degree of explained phenotypic variation and constitutes a promising avenue for gene discovery...
  18. ncbi Smoking relapse after 2 years of abstinence: findings from the VA Normative Aging Study
    Elizabeth A Krall
    Normative Aging Study, Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System, Boston, MA, USA
    Nicotine Tob Res 4:95-100. 2002
    ..Use of other tobacco products, coffee and alcohol increased the risk of late relapse. These findings may be useful in identifying those at highest risk for late relapse and for motivating former smokers to continue long-term abstinence...
  19. ncbi Nicotinic acetylcholine receptor genes on chromosome 15q25.1 are associated with nicotine and opioid dependence severity
    Porat M Erlich
    Center for Health Research, Geisinger Health System, 100 N Academy Avenue, Danville, PA 17822 4400, USA
    Hum Genet 128:491-9. 2010
    ..While the association of this locus with NDS and smoking phenotypes is well known, the association with ODS, a dimension of opioid substance dependence, is novel and requires verification in independent studies...
  20. ncbi Ventral striatum/nucleus accumbens activation to smoking-related pictorial cues in smokers and nonsmokers: a functional magnetic resonance imaging study
    Sean P David
    Cancer Research United Kingdom General Practice Research Group, Department of Clinical Pharmacology, University of Oxford, Radcliffe Infirmary, UK
    Biol Psychiatry 58:488-94. 2005
    ..Converging evidence from several theories of the development of incentive-sensitization to smoking-related environmental stimuli suggests that the ventral striatum plays an important role in the processing of smoking-related cue reactivity...
  21. ncbi Smoking cessation via the internet: a randomized clinical trial of an internet intervention as adjuvant treatment in a smoking cessation intervention
    Sandra J Japuntich
    Center for Tobacco Research and Intervention, University of Wisconsin School of Medicine and Public Health, 1930 Monroe Street, Suite 200, Madison, WI 53711, USA
    Nicotine Tob Res 8:S59-67. 2006
    ..05). In sum, results suggest that participants used CHESS SCRP frequently, CHESS SCRP use was related to success, but the effects in general did not yield intergroup effects...
  22. ncbi Tobacco use and cessation in psychiatric disorders: National Institute of Mental Health report
    Douglas Ziedonis
    University of Massachusetts Medical School and UMass Memorial Health Care, Worchester, MA01655, USA
    Nicotine Tob Res 10:1691-715. 2008
    ..Despite an accumulating literature for some specific psychiatric disorders and tobacco use and cessation, many unstudied research questions remain and are a focus and an emphasis of this review...
  23. ncbi In vivo nicotine treatment regulates mesocorticolimbic CREB and ERK signaling in C57Bl/6J mice
    Darlene H Brunzell
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    J Neurochem 84:1431-41. 2003
    ..Overall, these results support a role for ERK and CREB activity in neural plasticity associated with nicotine dependence...
  24. pmc A genetically modulated, intrinsic cingulate circuit supports human nicotine addiction
    L Elliot Hong
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Proc Natl Acad Sci U S A 107:13509-14. 2010
    ..Identifying where and how brain circuits link genes to smoking provides practical neural circuitry targets for new treatment development...
  25. ncbi American Cancer Society's QuitLink: randomized trial of Internet assistance
    K Joanne Pike
    American Cancer Society, Atlanta, GA, USA
    Nicotine Tob Res 9:415-20. 2007
    ..0% vs. 22.1% of followed participants). These findings show that interactive Internet sites yielding high levels of utilization can increase quitting success among smokers seeking assistance via the Internet...
  26. pmc A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction
    Robert B Weiss
    Department of Human Genetics, Eccles Institute of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
    PLoS Genet 4:e1000125. 2008
    ..The identification of an age-dependent susceptibility haplotype reinforces the importance of preventing early exposure to tobacco through public health policies...
  27. pmc Association of the CHRNA5-A3-B4 gene cluster with heaviness of smoking: a meta-analysis
    Jennifer J Ware
    Department of Psychological Medicine, Cardiff University, 1 Floor Neuadd Merionydd, Heath Park Campus, Cardiff CF14 4YS, UK
    Nicotine Tob Res 13:1167-75. 2011
    ..g., nicotine dependence) and diseases (e.g., lung cancer). Two single nucleotide polymorphisms (SNPs), rs16969968 in CHRNA5 and rs1051730 in CHRNA3, have generated particular interest...
  28. ncbi Psychometric properties of the Fagerström Test for Nicotine Dependence
    Izilda Carolina de Meneses-Gaya
    Department of Neurosciences and Behavior, Ribeirao Preto School of Medicine, University of Sao Paulo, Ribeirao Preto, Brazil
    J Bras Pneumol 35:73-82. 2009
    ..The objective of the present report was to review articles related to the psychometric properties of the FTND...
  29. pmc Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans
    N L Saccone
    Department of Genetics, Washington University, Saint Louis, MO 63110, USA
    Genes Brain Behav 9:741-50. 2010
    ..Multiple nicotinic receptor subunit genes outside chromosome 15q25 are likely to be important in the biological processes and development of nicotine dependence, and some of these risks may be shared across diverse populations...
  30. ncbi Anxiety, anxiety disorders, tobacco use, and nicotine: a critical review of interrelationships
    Sandra Baker Morissette
    Department of Psychiatry, Boston University School of Medicine, Boston, MA 02130, USA
    Psychol Bull 133:245-72. 2007
    ..Increased knowledge in these areas should inform prevention efforts as well as the development and improvement of smoking cessation programs for those with anxiety and other psychiatric disorders...
  31. ncbi Limbic activation to cigarette smoking cues independent of nicotine withdrawal: a perfusion fMRI study
    Teresa R Franklin
    Department of Psychiatry, Addiction Treatment Research Center, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 32:2301-9. 2007
    ....
  32. pmc A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations
    Penelope A Lind
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res Hum Genet 13:10-29. 2010
    ..Further studies will be required before the detailed causes of comorbidity between AD and ND are understood...
  33. ncbi Pooled analysis of tobacco use and risk of Parkinson disease
    Beate Ritz
    Department of Epidemiology and Environmental Health Sciences, UCLA School of Public Health, 650 Charles Young Smith Dr S, Los Angeles, CA 90095 1772, USA
    Arch Neurol 64:990-7. 2007
    ..This comprehensive assessment of the apparent reduced risk of PD associated with smoking may provide important leads for treatment and prevention...
  34. ncbi Tobacco dependence in the general population in Italy
    S Gallus
    Istituto di Ricerche Farmacologiche Mario Negri, Milan
    Ann Oncol 16:703-6. 2005
    ..Measures of tobacco dependence are mainly used in the clinical setting, but limited information is available on tobacco dependence on a population level...
  35. pmc Association of serum cotinine level with a cluster of three nicotinic acetylcholine receptor genes (CHRNA3/CHRNA5/CHRNB4) on chromosome 15
    Kaisu Keskitalo
    Department of Public Health, University of Helsinki, Finland
    Hum Mol Genet 18:4007-12. 2009
    ..13 for CPD. Variation at CHRNA5/CHRNA3/CHRNB4 cluster influences nicotine level, measured as cotinine, more strongly than smoking quantity, measured by CPD, and appears thus to be involved in regulation of nicotine levels among smokers...
  36. ncbi Smoking cessation treatment on the Internet: content, quality, and usability
    Beth Bock
    Centers for Behavioral and Preventive Medicine, Brown Medical School and The Miriam Hospital, Providence RI 02903, USA
    Nicotine Tob Res 6:207-19. 2004
    ..Web sites that provide direct treatment often fail to fully implement treatment guidelines and do not take full advantage of the interactive and tailoring capabilities of the Internet...
  37. pmc Modeling complex genetic and environmental influences on comorbid bipolar disorder with tobacco use disorder
    Richard C McEachin
    Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA
    BMC Med Genet 11:14. 2010
    ..characterized by severe mood swings, ranging from mania to depression, and up to a 70% rate of comorbid Tobacco Use Disorder (TUD)...
  38. ncbi Nicotine dependence and reward differ between adolescent and adult male mice
    D Kota
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 322:399-407. 2007
    ..These data indicate that the underlying receptor mechanisms of nicotine dependence differ for adults and adolescents, suggesting that the effectiveness of smoking cessation therapies will differ for various age groups...
  39. pmc Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals
    Esther H Lips
    International Agency for Research on Cancer IARC, Lyon, France
    Int J Epidemiol 39:563-77. 2010
    ....
  40. ncbi An evaluation of a clinical approach to staging tobacco addiction
    Joseph R DiFranza
    Department of Family Medicine and Community Health, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Pediatr 159:999-1003.e1. 2011
    ..To determine whether adolescents' symptom reports are consistent with the developmental sequence of tobacco addiction and whether the sequential appearance of these symptoms signifies increasing addiction...
  41. pmc Nicotinic α5 receptor subunit mRNA expression is associated with distant 5' upstream polymorphisms
    Ryan M Smith
    Neuroscience Graduate Studies Program, Department of Pharmacology, The Ohio State University, Columbus, OH 43210, USA
    Eur J Hum Genet 19:76-83. 2011
    ..Ethnic differences in LD across the CHRNA5 locus require consideration of upstream enhancer variants when testing clinical associations...
  42. pmc The nicotinic acetylcholine receptor CHRNA5/A3/B4 gene cluster: dual role in nicotine addiction and lung cancer
    Ma Reina D Improgo
    Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, 303 Belmont Street, Worcester, MA 01604, United States
    Prog Neurobiol 92:212-26. 2010
    ..Here, we review this body of work, focusing on the clustered nicotinic acetylcholine receptor genes and evaluating their role in nicotine addiction and lung cancer...
  43. pmc Neural correlates of craving and resisting craving for tobacco in nicotine dependent smokers
    Karen J Hartwell
    Medical University of South Carolina, Charleston, 29425, USA
    Addict Biol 16:654-66. 2011
    ..Different strategies for resisting, such as distraction, activated different regions. Understanding the underlying neurobiology of resisting craving to smoke may identify new foci for treatments...
  44. ncbi Nicotine reduction revisited: science and future directions
    Dorothy K Hatsukami
    Tobacco Use Research Center, University of Minnesota, 717 Delaware St SE, Minneapolis, Minnesota 55414, USA
    Tob Control 19:e1-10. 2010
    ..This article provides an overview of the current science in the area of reduced nicotine content cigarettes and key conclusions and recommendations for research and policy that emerged from the deliberations of the meeting members...
  45. pmc Nicotinic receptor gene variants influence susceptibility to heavy smoking
    Victoria L Stevens
    Department of Epidemiology and Surveillance Research, American Cancer Society, 250 Williams Street Northwest, Atlanta, GA 30303 1002, USA
    Cancer Epidemiol Biomarkers Prev 17:3517-25. 2008
    ..Our findings identify two loci in the CHRNA5-CHRNA3-CHRNB4 gene cluster that predict smoking behavior and provide strong evidence for the involvement of the alpha5 nicotinic receptor in heavy smoking...
  46. ncbi Smoking cessation in methadone maintenance
    Steve Shoptaw
    Friends Research Institute, Los Angeles, CA, UCLA, Department of Psychiatry, Los Angeles, CA 90025, USA
    Addiction 97:1317-28; discussion 1325. 2002
    ..To evaluate relapse prevention (relapse prevention) and contingency management (contingency management) for optimizing smoking cessation outcomes using nicotine replacement therapy for methadone-maintained tobacco smokers...
  47. pmc The reliability and predictive validity of the Heaviness of Smoking Index and its two components: findings from the International Tobacco Control Four Country study
    R Borland
    VicHealth Centre for Tobacco Control, The Cancer Council Victoria, Victoria, Australia
    Nicotine Tob Res 12:S45-50. 2010
    ..There is increasing recognition that the two measures in the Heaviness of Smoking Index (HSI), time to first cigarette of the day (TTFC) and daily consumption (cigarettes per day [CPD]), are strong predictors of quitting behavior...
  48. ncbi Long-term smoking relapse: a study using the british household panel survey
    James Hawkins
    Department of Social Medicine, University of Bristol, Bristol, United Kingdom
    Nicotine Tob Res 12:1228-35. 2010
    ..We estimate the incidence of relapse and evaluate demographic, health, socioeconomic characteristics, and episodic events associated with an increased probability of relapse...
  49. ncbi Smoking care provision in hospitals: a review of prevalence
    Megan Freund
    Hunter New England Population Health, University of Newcastle, and Hunter Medical Research Institute, NSW, Australia
    Nicotine Tob Res 10:757-74. 2008
    ..In addition, standardized measures of smoking care should be developed. Hospital organizations should enhance and continue to monitor their delivery of smoking care...
  50. pmc Parent, sibling and peer influences on smoking initiation, regular smoking and nicotine dependence. Results from a genetically informative design
    Jeffrey F Scherrer
    St Louis Veterans Affairs Medical Center, Research Service 151 JC, 915 North Grand Blvd, St Louis, MO 63106, USA
    Addict Behav 37:240-7. 2012
    ..Smoking interventions may have greatest impact by targeting smoking prevention among peer groups in adolescent and young adult populations...
  51. ncbi Sex differences in subclinical and DSM-IV pathological gambling: results from the National Epidemiologic Survey on Alcohol and Related Conditions
    Carlos Blanco
    Department of Psychiatry, Columbia University New York State Psychiatric Institute, New York, NY, USA
    Psychol Med 36:943-53. 2006
    ..To examine sex differences in DSM-IV subclinical and pathological gambling in nationally representative data of the US population...
  52. ncbi Reduced nicotine content cigarettes: effects on toxicant exposure, dependence and cessation
    Dorothy K Hatsukami
    University of Minnesota Transdisciplinary Tobacco Use Research Center, Minneapolis, MN 55414, USA
    Addiction 105:343-55. 2010
    ..To examine the effects of reduced nicotine cigarettes on smoking behavior, toxicant exposure, dependence and abstinence...
  53. pmc Inhibition of anandamide hydrolysis by cyclohexyl carbamic acid 3'-carbamoyl-3-yl ester (URB597) reverses abuse-related behavioral and neurochemical effects of nicotine in rats
    Maria Scherma
    Preclinical Pharmacology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    J Pharmacol Exp Ther 327:482-90. 2008
    ..These findings suggest that FAAH inhibition can counteract the addictive properties of nicotine and that FAAH may serve as a new target for development of medications for treatment of tobacco dependence...
  54. ncbi Pharmacotherapy for smoking cessation: current advances and research topics
    Tobias Raupach
    Department of Cardiology and Pneumology, University Hospital Gttingen, Gttingen, Germany
    CNS Drugs 25:371-82. 2011
    ..In addition, public smoking bans and reimbursement of medication costs are crucial in reducing the future burden of disease caused by smoking on a global level...
  55. ncbi A double-blind randomized placebo-controlled pilot study of neuropsychiatric adverse events in abstinent smokers treated with varenicline or placebo
    Dahlia Garza
    Pfizer Pharmaceuticals Inc, New York, New York 10017, USA
    Biol Psychiatry 69:1075-82. 2011
    ..There have been spontaneous postmarketing reports of neuropsychiatric adverse events (NPAEs) in smokers without a history of psychiatric illness quitting with varenicline...
  56. ncbi Changes in smoking associated with an acute health event: theoretical and practical implications
    Edwin D Boudreaux
    Department of Emergency Medicine, UMDNJ Robert Wood Johnson Medical School and Cancer Institute of New Jersey at Cooper University Hospital, Camden, New Jersey 08103, USA
    Ann Behav Med 33:189-99. 2007
    ..Experiencing a serious adverse behavior-related consequence may motivate behavior change...
  57. ncbi Smoking increases the risk of panic: findings from a prospective community study
    Barbara Isensee
    Clinical Psychology and Epidemiology Unit, Max Planck Institute of Psychiatry, Munich, Germany
    Arch Gen Psychiatry 60:692-700. 2003
    ..We examined prospectively determined bidirectional associations between smoking and panic and other anxiety disorders and their temporal ordering of onset in a representative community sample of adolescents and young adults...
  58. ncbi Interactions between age and the aversive effects of nicotine withdrawal under mecamylamine-precipitated and spontaneous conditions in male Wistar rats
    Megan J Shram
    Department of Neuroscience, Centre for Addiction and Mental Health, 33 Russell Street, T700, Toronto, ON, Canada M5S 2S1
    Psychopharmacology (Berl) 198:181-90. 2008
    ..Although adolescents may exhibit a greater susceptibility to nicotine addiction, relatively little is known about the influence of the aversive effects of nicotine withdrawal in maintaining smoking behavior...
  59. ncbi Nicotine induces conditioned place preferences over a large range of doses in rats
    Bernard Le Foll
    Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 178:481-92. 2005
    ..Conditioned place preference (CPP) procedures provide one measure of potential rewarding effects of abused drugs. Many attempts to induce CPP with nicotine have been unsuccessful...
  60. pmc Noradrenergic alpha1 receptors as a novel target for the treatment of nicotine addiction
    Benoit Forget
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, Canada
    Neuropsychopharmacology 35:1751-60. 2010
    ..The findings point to alpha(1) adrenoceptor blockade as a potential new approach to the treatment of tobacco dependence in humans...
  61. ncbi Metabotropic glutamate 2/3 receptors in the ventral tegmental area and the nucleus accumbens shell are involved in behaviors relating to nicotine dependence
    Matthias E Liechti
    Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 27:9077-85. 2007
    ..Together, these findings indicate an important role for mGlu2/3 receptors in the posterior VTA and the NAc shell in the mediation of the rewarding effects of nicotine and potentially in cue-induced nicotine-seeking behavior...
  62. ncbi Repeated administration of the GABAB receptor agonist CGP44532 decreased nicotine self-administration, and acute administration decreased cue-induced reinstatement of nicotine-seeking in rats
    Neil E Paterson
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 30:119-28. 2005
    ..125 and 0.25 mg/kg) dose-dependently decreased cue-induced reinstatement of nicotine-seeking behavior...
  63. ncbi Predictors of smoking relapse by duration of abstinence: findings from the International Tobacco Control (ITC) Four Country Survey
    Natalie Herd
    Department of Psychology, The University of Melbourne, Melbourne, Vic, Australia
    Addiction 104:2088-99. 2009
    ..To explore predictors of smoking relapse and how predictors vary according to duration of abstinence...
  64. ncbi Role of mentholated cigarettes in increased nicotine dependence and greater risk of tobacco-attributable disease
    Samuel Garten
    Department of Social and Preventive Medicine, State University of New York, Buffalo, NY, USA
    Prev Med 38:793-8. 2004
    ..The "cool sensation" experienced by the menthol smoker can result in a reflex-depressive effect on respiratory activity...
  65. ncbi Evaluation of the brief questionnaire of smoking urges (QSU-brief) in laboratory and clinical settings
    L S Cox
    Nicotine Research Center, Mayo Clinic, Mayo Foundation, Rochester, MN 55905, USA
    Nicotine Tob Res 3:7-16. 2001
    ..The findings supported a multidimensional conceptualization of craving to smoke and demonstrated the utility of a brief multidimensional measure of craving...
  66. pmc Internet- vs. telephone-administered questionnaires in a randomized trial of smoking cessation
    Amanda L Graham
    Center for Alcohol and Addiction Studies, Brown Medical School, Providence, Rhode Island, USA
    Nicotine Tob Res 8:S49-57. 2006
    ..Results indicate that the internal consistency and test-retest reliability of the measures examined are comparable when self-administered via the Internet or when interviewer-administered via telephone...
  67. pmc CHRNA3 rs1051730 genotype and short-term smoking cessation
    Marcus R Munafo
    School of Experimental Psychology, University of Bristol, Bristol, UK
    Nicotine Tob Res 13:982-8. 2011
    ..We investigated the potential association of rs1051730 genotype with reduced likelihood of smoking cessation in 2 cohorts of treatment-seeking smokers in primary care in the United Kingdom...
  68. pmc Time to first cigarette in the morning as an index of ability to quit smoking: implications for nicotine dependence
    Timothy B Baker
    Nicotine Tob Res 9:S555-70. 2007
    ..Thus the time-to-first-cigarette item appears to tap a pattern of heavy, uninterrupted, and automatic smoking and may be a good single-item measure of nicotine dependence...
  69. pmc A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependence
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, Box 8134, St Louis, Missouri 63110, USA
    Biol Psychiatry 64:922-9. 2008
    ..The goal of this study was to examine the association of this variant with cocaine dependence...
  70. pmc The CHRNA5/A3/B4 gene cluster variability as an important determinant of early alcohol and tobacco initiation in young adults
    Isabel R Schlaepfer
    Institute for Behavioral Genetics, Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA
    Biol Psychiatry 63:1039-46. 2008
    ..Significant results were then replicated in a separate adult population-representative sample...
  71. ncbi Posttraumatic stress disorder and the incidence of nicotine, alcohol, and other drug disorders in persons who have experienced trauma
    Naomi Breslau
    Department of Psychiatry, Henry Ford Health System, Detroit, MI 48202 3450, USA
    Arch Gen Psychiatry 60:289-94. 2003
    ..We examine whether exposure to traumatic events increases the risk for nicotine dependence or alcohol or other drug use disorders, independent of posttraumatic stress disorder (PTSD)...
  72. ncbi Association of adolescent symptoms of depression and anxiety with daily smoking and nicotine dependence in young adulthood: findings from a 10-year longitudinal study
    Maria McKenzie
    Centre for Adolescent Health, Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Victoria, Australia
    Addiction 105:1652-9. 2010
    ..To examine the association of adolescent depression and anxiety symptoms with daily smoking and nicotine dependence in young adulthood...
  73. pmc Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium
    Therese Truong
    Genetic Epidemiology Group, International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon Cedex 08, France
    J Natl Cancer Inst 102:959-71. 2010
    ....
  74. ncbi Association of the neuronal nicotinic receptor beta2 subunit gene (CHRNB2) with subjective responses to alcohol and nicotine
    Marissa A Ehringer
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309, USA
    Am J Med Genet B Neuropsychiatr Genet 144:596-604. 2007
    ..This study provides the first evidence for association between the CHRNB2 gene and nicotine- and alcohol-related phenotypes, and suggests that polymorphisms in CHRNB2 may be important in mediating early responses to nicotine and alcohol...
  75. pmc Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes
    Nancy L Saccone
    Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Med Genet B Neuropsychiatr Genet 150:453-66. 2009
    ....
  76. ncbi Strength of urges to smoke as a measure of severity of cigarette dependence: comparison with the Fagerström Test for Nicotine Dependence and its components
    Jennifer A Fidler
    Health Behaviour Research Centre, Department of Epidemiology and Public Health, University College London, UK
    Addiction 106:631-8. 2011
    ..This study compared ratings of Strength of Urges to Smoke (SUTS) with the Fagerström Test of Nicotine Dependence (FTND) and its components, including the Heaviness of Smoking Index (HSI)...
  77. pmc Human neuronal acetylcholine receptor A5-A3-B4 haplotypes are associated with multiple nicotine dependence phenotypes
    Timothy B Baker
    Department of Medicine, Center for Tobacco Research and Intervention, University of Wisconsin School of Medicine and Public Health, 1930 Monroe Street, Suite 200, Madison, WI 53711, USA
    Nicotine Tob Res 11:785-96. 2009
    ..e., withdrawal severity, ability to stop smoking, and specific scales on the Wisconsin Inventory of Smoking Dependence Motives (WISDM-68) that reflect loss of control, strong craving, and heavy smoking...
  78. ncbi Heritability of smoking initiation and nicotine dependence
    Jacqueline M Vink
    Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
    Behav Genet 35:397-406. 2005
    ..The substantial impact of genetic factors on nicotine dependence emphasizes the need for further research to localize and identify specific genes and pathways involved in nicotine dependence...
  79. ncbi Cue dependency of nicotine self-administration and smoking
    A R Caggiula
    Department of Psychology, 455 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Pharmacol Biochem Behav 70:515-30. 2001
    ....
  80. pmc Patterns of dual use of cigarettes and smokeless tobacco among US males: findings from national surveys
    Scott L Tomar
    Department of Community Dentistry and Behavioral Science, University of Florida College of Dentistry, Suite 5180, Gainesville, Florida 32610 3628, USA
    Tob Control 19:104-9. 2010
    ..This study examined patterns of concurrent use of smokeless tobacco (ST) and cigarettes among young people and adults in the USA just before cigarette companies' control of the nation's ST market...
  81. pmc Cigarette smoking saturates brain alpha 4 beta 2 nicotinic acetylcholine receptors
    Arthur L Brody
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA
    Arch Gen Psychiatry 63:907-15. 2006
    ....
  82. pmc A comparison of the Fagerström Test for Nicotine Dependence and smoking prevalence across countries
    Karl Fagerström
    Smoker s Information Centre, Sweden
    Addiction 103:841-5. 2008
    ..To examine the correlation between the Fagerström Test for Nicotine Dependence (FTND) score and smoking prevalence across countries...
  83. ncbi Activation in mesolimbic and visuospatial neural circuits elicited by smoking cues: evidence from functional magnetic resonance imaging
    Deborah L Due
    Department of Psychological and Brain Sciences, Duke University, Durham, NC 27709, USA
    Am J Psychiatry 159:954-60. 2002
    ..The authors sought to increase understanding of the brain mechanisms involved in cigarette addiction by identifying neural substrates modulated by visual smoking cues in nicotine-deprived smokers...
  84. ncbi Defining nicotine dependence for genetic research: evidence from Australian twins
    Christina N Lessov
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    Psychol Med 34:865-79. 2004
    ....
  85. pmc Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery
    Henry A Lester
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    AAPS J 11:167-77. 2009
    ..One important implication of the SePhaChARNS hypothesis is that therapeutically relevant nicotinic receptor drugs could be discovered by studying events in intracellular compartments rather than exclusively at the surface membrane...
  86. ncbi Diagnostic accuracy of NicAlert cotinine test strips in saliva for verifying smoking status
    Fiona Cooke
    Market Economics Ltd, Auckland, New Zealand
    Nicotine Tob Res 10:607-12. 2008
    ..The use of NCTS is a valid and reliable method, compared with GC, to test saliva samples for verification of smoking status...
  87. ncbi Smoking patterns during pregnancy and postnatal period and depressive symptoms
    Marcus R Munafo
    Department of Experimental Psychology, University of Bristol, Bristol BS8 1TU
    Nicotine Tob Res 10:1609-20. 2008
    ..Future studies should explore this possibility in more detail, including whether these relationships differ in clinical and nonclinical samples...
  88. pmc The Fagerström Test for Nicotine Dependence-Smokeless Tobacco (FTND-ST)
    Jon O Ebbert
    Nicotine Research Program, Primary Care Internal Medicine, Department of Internal Medicine, Mayo Clinic 200 1st Street Southwest, Rochester, MN 55905, USA
    Addict Behav 31:1716-21. 2006
    ..Development and refinement of nicotine dependence measures for ST users are essential steps in order to advance the field of ST research...
  89. ncbi Cellular and synaptic mechanisms of nicotine addiction
    Huibert D Mansvelder
    Vrije Universiteit Amsterdam, Faculty of Earth and Life Sciences, De Boelelaan 1085, 1081 HV, Amsterdam, The Netherlands
    J Neurobiol 53:606-17. 2002
    ..Assessing the relative importance of these molecular phenomena in the behavioral effects of nicotine presents an exciting challenge for future research efforts...
  90. ncbi Nicotine and nonnicotine factors in cigarette addiction
    Jed E Rose
    Center for Nicotine and Smoking Cessation Research, Duke University Medical Center, 2424 Erwin Road, Suite 201, Durham, NC 27705, USA
    Psychopharmacology (Berl) 184:274-85. 2006
    ..These include constituents that provide reinforcing sensory stimulation, components that minimize excessive irritation from inhaled nicotine and other pharmacologically active compounds in cigarette smoke...
  91. ncbi Clinical pharmacology of nicotine: implications for understanding, preventing, and treating tobacco addiction
    N L Benowitz
    Department of Medicine, University of California, San Francisco, California, USA
    Clin Pharmacol Ther 83:531-41. 2008
    ....
  92. pmc Fagerstrom test for nicotine dependence vs heavy smoking index in a general population survey
    M Pérez-Ríos
    Directorate General for Public Health, Galician Regional Health Authority, Santiago de Compostela, Spain
    BMC Public Health 9:493. 2009
    ..A shorter test derived from the FTND used for the general population is the Heavy Smoking Index (HSI) (six questions vs. two). The objective of this study is to compare the validity of the HSI versus the FTND...
  93. pmc Convergence of genetic findings for nicotine dependence and smoking related diseases with chromosome 15q24-25
    Laura Jean Bierut
    Washington University School of Medicine, 660 South Euclid, Box 8134, St Louis, MO 63110, USA
    Trends Pharmacol Sci 31:46-51. 2010
    ..This represents an exciting convergence of genetic findings, and highlights the potential for research on smoking to inform public health...
  94. ncbi Health system changes to facilitate the delivery of tobacco-dependence treatment
    Michael C Fiore
    University of Wisconsin Center for Tobacco Research and Intervention, Madison, Wisconsin 53711, USA
    Am J Prev Med 33:S349-56. 2007
    ..Further research to optimize the effectiveness and adoption of these strategies will help ensure that patients receive evidence-based interventions that foster tobacco-use cessation...
  95. ncbi Addressing tobacco among individuals with a mental illness or an addiction
    Jill M Williams
    UMDNJ Robert Wood Johnson Medical School, Division of Addiction Psychiatry, UMDNJ SPH, Tobacco Dependence Program, 317 George Street, Suite 210, New Brunswick, NJ 08901, USA
    Addict Behav 29:1067-83. 2004
    ..More research is needed as well as a national organized effort to address tobacco in this large segment of smokers...
  96. ncbi The relationship between tobacco use, substance-use disorders and mental health: results from the National Survey of Mental Health and Well-being
    L Degenhardt
    National Drug and Alcohol Research Centre, University of NSW, Sydney 2052, Australia
    Nicotine Tob Res 3:225-34. 2001
    ..To examine comorbidity between tobacco use, substance-use disorders and mental health problems among Australian adults aged 18 years and over...
  97. pmc Alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking
    W Berrettini
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Mol Psychiatry 13:368-73. 2008
    ..These results (in three independent populations of European origin, totaling approximately 15 000 individuals) suggest that a common haplotype in the CHRNA5/CHRNA3 gene cluster on chromosome 15 contains alleles, which predispose to ND...
  98. ncbi Role of dopamine in the behavioural actions of nicotine related to addiction
    G Di Chiara
    Department of Toxicology and CNR Center of Neuropharmacology, University of Cagliari, Viale Diaz 182, 09100 Cagliari, Italy
    Eur J Pharmacol 393:295-314. 2000
    ..Unavailability of tobacco disrupts the automatic, implicit modality of abnormal habit responding switching responding into the explicit, conscious modality of incentive drug-seeking and craving...
  99. pmc The effectiveness and cost effectiveness of telephone counselling and the nicotine patch in a state tobacco quitline
    Jack F Hollis
    Center for Health Research, Kaiser Permanente Northwest, Portland, OR 97227, USA
    Tob Control 16:i53-9. 2007
    ..We examined the effectiveness and cost effectiveness of offering callers single session versus multisession counselling, with or without free nicotine patches...
  100. pmc The tobacco use management system: analyzing tobacco control from a systems perspective
    Ron Borland
    VicHealth Centre for Tobacco Control, Cancer Council Victoria, Victoria, Australia
    Am J Public Health 100:1229-36. 2010
    ..We argue that this goal would be more readily achieved if the regulatory subsystem had dynamic power to regulate tobacco products and the tobacco industry as well as a responsive process for resourcing tobacco use control activities...

Research Grants70

  1. Mechanisms Linking Hostility and Smoking
    Christopher Kahler; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  2. Effects of Nicotine in Smokers with Anxious Mood
    Sandra Morissette; Fiscal Year: 2007
    ..Baker- Morissette, and ensure the next step of her programmatic research, which has an excellent probabilit3-to increase our understanding of the links between nicotine, negative affect and tobacco use disorder.
  3. EVALUATION OF A CIGARETTE SUBSTITUTE
    John Hughes; Fiscal Year: 2001
    ..We believe it imperative to begin studying these substitutes so that, unlike low-tar/low nicotine cigarettes, we will know whether their introduction is good or bad for public health. ..
  4. Internal Barriers to Seeking Smoking Cessation Treatment
    John Hughes; Fiscal Year: 2007
    ..Our results will suggest messages for media campaigns and for clinicians to use to motivate smokers to access proven treatments. ..
  5. Gradual vs Abrupt Cessation Treatment for Smoking
    John Hughes; Fiscal Year: 2007
    ..This study will be the first large, systematic test of gradual vs. abrupt cessation. ..
  6. Natural History of Attempts to Stop Smoking
    John R Hughes; Fiscal Year: 2010
    ....
  7. High Dose Nicotine Patch Therapy for Spit Tobacco Users
    Jon Ebbert; Fiscal Year: 2004
    ..Our goal is to reduce the prevalence of ST use and decrease the incidence of oropharyngeal cancer through the development of effective treatment options for ST users. ..
  8. Evaluating Nicotine Lozenges for Treatment of Smokeless Tobacco Addiction
    Jon Ebbert; Fiscal Year: 2009
    ..No drug therapies have been shown to be effective for helping smokeless tobacco users quit for good. The purpose of this study is to test drugs that can be used to help smokeless tobacco users quit for good. ..
  9. Brief Dental Office Intervention with Tobacco Quitline
    Jon Ebbert; Fiscal Year: 2005
    ..S. adult population smoking; and 3) 75% of smokers quitting for at least one day or longer because they are trying to quit. ..
  10. The Transition of Nicotine Dependence
    Joseph DiFranza; Fiscal Year: 2005
    ..A new theory-based measure of early dependence for youths will be tested against established measures of dependence. ..
  11. Imaging of nicotine sensitization in humans: a translational application of fMRI
    Joseph DiFranza; Fiscal Year: 2008
    ..The long-term goal is to use this new tool to see how addictive drugs alter the brain, and thereby identify targets for the development of new drugs to treat addiction. [unreadable] [unreadable] [unreadable]..
  12. Innovative Interventions for Smoking Cessation
    Dorothy K Hatsukami; Fiscal Year: 2010
    ..The results of this study will provide useful information on directions to pursue to improve our pharmacotherapies and behavioral treatments and to better understand the various aspects of addiction. ..
  13. Interventions for Tobacco Dependent Adolescents
    Dorothy Hatsukami; Fiscal Year: 2005
    ....
  14. DISCRIMINATIVE STIMULUS EFFECTS OF NICOTINE
    Kenneth Perkins; Fiscal Year: 2001
    ....
  15. TOBACCO EXPOSURE REDUCTION
    Dorothy Hatsukami; Fiscal Year: 2008
    ..The results of research from this TTURC will provide the scientific basis for urgent policy, public education, and regulatory efforts to reduce tobacco harm. ..
  16. Affect, Context, and Placebo Responses to Nicotine
    Kenneth Perkins; Fiscal Year: 2005
    ..Secondary analyses may identify important individual characteristics associated with placebo responses, aiding in the prediction of which smokers ultimately are likely to benefit most from manipulation of placebo effects. ..
  17. TREATMENT OF SMOKELESS TOBACCO USERS
    Dorothy Hatsukami; Fiscal Year: 2008
    ..PERFORMANCE SITE ========================================Section End=========================================== ..
  18. INDIVIDUAL VARIATION IN NICOTINE SENSITIVITY IN HUMANS
    Kenneth Perkins; Fiscal Year: 2003
    ..e., in nicotine-naive individuals). Results will provide directions for future research on vulnerability to tobacco dependence and for targeted efforts to prevent smoking onset. ..
  19. SEX DIFFERENCES IN NICOTINE REINFORCEMENT: HUMAN/ANIMAL
    Kenneth Perkins; Fiscal Year: 2003
    ....
  20. Tobacco Smoking, Nicotine and Negative Affect Relief
    Kenneth Perkins; Fiscal Year: 2009
    ..In sum, this research will help address the fundamental question of why cigarette smoking is reinforcing. ..
  21. Treatments for Nicotine Dependence: Brain Mechanisms
    Arthur Brody; Fiscal Year: 2005
    ..abstract_text> ..
  22. Smoking Cessation for Head and Neck Cancer Patients
    Robert Schnoll; Fiscal Year: 2006
    ..In turn, our findings may help guide the implementation of smoking cessation treatments for all cancer patients within Comprehensive Cancer Centers in the US. ..
  23. Individual Differences in Smoking Exposure and Nicotine Dependence Sensitivity
    Lisa C Dierker; Fiscal Year: 2010
    ....
  24. Drug Cue Reactivity in Smokers: An fMRI Investigation
    Francis McClernon; Fiscal Year: 2002
    ..The results of this study will enhance our understanding of the neurobiological basis of tobacco dependence, inform treatment development, and generate additional hypotheses and research plans. ..
  25. SCALING THE REINFORCING VALUE OF CIGARETTE SMOKE
    Jed Rose; Fiscal Year: 2003
    ..The results will lead to a better understanding of the role of pharmacologic and sensory/behavioral cues in nicotine addiction and smoking cessation. ..
  26. INTERNAL COUNCIL FOR TOBACCO RESEARCH AND TOBACCO INSTIT
    K Cummings; Fiscal Year: 2002
    ..We anticipate that this information will assist policy makers in evaluating current regulatory measures to curtail tobacco usage. ..
  27. GABA Medications for Tobacco Addiction
    Mehmet Sofuoglu; Fiscal Year: 2009
    ..The findings of this study will provide valuable information to develop new pharmacotherapies for smoking cessation. ..
  28. Cocaine Withdrawal and Pharmacotherapy Response
    Mehmet Sofuoglu; Fiscal Year: 2010
    ..This proposal, by testing the efficacy of carvedilol and investigating the influence of withdrawal severity on carvedilol's efficacy, may result in development of more effective treatments for cocaine addiction. ..
  29. The Impact of Product Information on Smoking Behavior
    K Cummings; Fiscal Year: 2004
    ..The findings from this study also have important policy implications, as one of the cornerstones of government product regulation is to ensure that consumers are informed about the inherent dangers of the products that they are using. ..
  30. Progestrone and the Effects of Nicotine
    Mehmet Sofuoglu; Fiscal Year: 2006
    ..By characterizing the progesterone effects on nicotine dependence, this study may provide a better understanding of the mechanisms which mediate the sex and menstrual cycle phase effects on nicotine dependence. ..
  31. FOLLOW UP OF THE COMMIT COHORT PARTICIPANTS 13 YEARS LAT
    K Cummings; Fiscal Year: 2002
    ....
  32. Neuroimaging Attentional Impairment During Abstinence
    Francis McClernon; Fiscal Year: 2008
    ..Dr. McClernon will continue to administer current awards and compete for additional extramural funding while he completes the goals of the application. [unreadable] [unreadable] [unreadable] [unreadable]..
  33. Role of depression and anxiety in the tobacco epidemic
    Renee Goodwin; Fiscal Year: 2008
    ..Use of the NESARC offers a unique opportunity to analyze a large, longitudinal, epidemiologic dataset. ..
  34. RELAPSE PROCESS IN TRANSDERMAL NICOTINE REPLACEMENT
    Saul Shiffman; Fiscal Year: 2001
    ....
  35. NICOTINE DEPENDENCE AMONG US YOUTHS
    Denise Kandel; Fiscal Year: 2003
    ..The proposed study will generate a unique understanding of the epidemiology, natural history, correlates and etiology of smoking and nicotine dependence among young people ..
  36. Nicotine Dependence in Early Adulthood
    Denise B Kandel; Fiscal Year: 2010
    ..The findings will indicate when, with whom, and how to intervene in order to prevent and reduce progression to nicotine dependence. ..
  37. The Transition to Nicotine Dependence in Adolescence
    Denise Kandel; Fiscal Year: 2005
    ..The study will generate a unique understanding of the natural history, etiology and consequences of nicotine dependence among young people. ..
  38. DIFFERENTIATION OF PHENOTYPES FOR SMOKING
    Ovide Pomerleau; Fiscal Year: 2003
    ..abstract_text> ..
  39. Comorbid childhood anxiety and asthma
    Renee Goodwin; Fiscal Year: 2006
    ..That study will involve a longitudinal epidemiologic preventive intervention study aimed at reducing the risk of anxiety disorders among pediatric asthma/allergy patients. ..
  40. Candidate Genes for Smoking In Related and Unrelated Individuals
    Ovide Pomerleau; Fiscal Year: 2007
    ..abstract not provided ..
  41. Understanding Emerging Patterns of Non-Daily Smoking: Field and Lab Assessments
    Saul Shiffman; Fiscal Year: 2010
    ....
  42. Effects of family smoking history in never-smokers
    Ovide Pomerleau; Fiscal Year: 2006
    ....
  43. Substance Dependence/Abuse in the U.S.Population
    Denise Kandel; Fiscal Year: 2004
    ..Such questions by and large have not been treated in the epidemiological literature on drug use in the general population, which has focused almost exclusively on frequency measures of drug use. ..
  44. Safety of Nicotine Reduction Strategy
    Neal Benowitz; Fiscal Year: 2009
    ..The proposed research is needed to guide governmental regulators as to how best to regulate nicotine in cigarettes and is an essential first step in examining the feasibility of a national regulation program. ..
  45. Parent Communication of BRCA1/2 Test Results to Children
    KENNETH TERCYAK; Fiscal Year: 2009
    ..Findings generated in this area offer a new paradigm within which to view and understand the psychosocial outcomes of predictive testing among tested parents and their nontested children. ..
  46. Treatment Issues In Smokers with Schizophrenia
    Marc Steinberg; Fiscal Year: 2008
    ..The plan will include important hands-on learning experiences, workshops, class work, attendance at national scientific conferences, and strong mentoring relationships. ..
  47. BIOBEHAVIORAL LUNG CANCER PREVENTION PROGRAM
    Caryn Lerman; Fiscal Year: 2004
    ..The long-term objective is to provide information necessary to match smoking cessation treatments to individuals, based on their genetic predispositions. ..
  48. Pediatric Cancer Prevention and Control
    KENNETH TERCYAK; Fiscal Year: 2006
    ..I expect that this intervention will lead to the development of an R01 grant to evaluate the effectiveness of alternate interventions for pediatric smoking cessation in medical and other settings. ..
  49. Pharmacogenetic Investigation of Naltrexone
    Caryn Lerman; Fiscal Year: 2007
    ..The long-term objective of this research is to discover and develop new pharmacogenetic treatment models that can be readily translated to the clinical setting to individualize pharmacotherapy and maximize effectiveness. ..
  50. A Telephone-Based Cancer Education & Prevention Intervention for Teens
    KENNETH TERCYAK; Fiscal Year: 2007
    ..Additionally, this study will lay the foundation for future, larger studies of intervention effectiveness, reach, and impact in this population. [unreadable] [unreadable] [unreadable]..
  51. Effects of Menthol on Bupropion Pharmacokinetics
    Kolawole Okuyemi; Fiscal Year: 2006
    ..abstract_text> ..
  52. Primary Care Genetics Cancer Prevention Conference
    Sean David; Fiscal Year: 2003
    ..abstract_text> ..
  53. Psychobiological /Genetic Determinants-Smoking Cessation
    Sean David; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  54. Addressing Light Smoking in African Americans
    Kolawole Okuyemi; Fiscal Year: 2006
    ..The research may provide crucial information to advance our understanding of smoking and set the stage for further research in this understudied population of AA cigarette smokers. ..
  55. Perfusion fMRI of Cue-Induced Nicotine Craving
    Teresa Franklin; Fiscal Year: 2005
    ..Thus, research into its neurological underpinnings is critical in guiding the development of behavioral and pharmacological therapies to battle nicotine addiction. ..
  56. Improving Varenicline Adherence and Outcome in Homeless Smokers
    Kolawole S Okuyemi; Fiscal Year: 2010
    ....
  57. NICOTINE AND SMOKING CESSATION IN SCHIZOPHRENIA
    A Evins; Fiscal Year: 2005
    ....
  58. Describing and Measuring Tobacco Treatment in Drug Treatment
    Kimber Richter; Fiscal Year: 2008
    ..Project findings will support future policy and research to strengthen tobacco treatment services in substance abuse treatment. [unreadable] [unreadable] [unreadable]..
  59. Deciphering genes and pathways in nicotine dependence
    Ming Li; Fiscal Year: 2008
    ..The completion of the proposed studies will advance our understanding of complex gene expression patterns associated with nicotine dependence and nicotine withdrawal in rats and in human postmortem brain tissues. ..
  60. Adolescence: A Sensitive Period for Nicotine Addiction
    Edward Levin; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  61. Improving Smoking Cessation Outcomes in Heavy Drinkers
    Christopher Kahler; Fiscal Year: 2006
    ..Developing effective interventions that address alcohol use during smoking cessation treatment can make a major public health impact on this large, yet neglected, subgroup of smokers. ..
  62. Neurobehavioral Regulation of Cigarette Cravings
    Brian Hitsman; Fiscal Year: 2008
    ..abstract_text> ..
  63. Health Communications and Risk Processing Among Smokers
    JENNIFER VIDRINE; Fiscal Year: 2006
    ..Findings have the potential to shed light on important mechanisms that may influence the construction of risk perceptions and on how perceptions of risk and smoking behavior may be reciprocally related. ..
  64. Literacy and Smoking Risk Communications
    JENNIFER VIDRINE; Fiscal Year: 2009
    ..Moreover, findings will be directly relevant to translation of the basic behavioral science underlying smoking risk communications into enhanced smoking cessation treatment approaches. ..
  65. Tobacco Cessation via Public Health Dental Clinics
    Judith Gordon; Fiscal Year: 2008
    ..4) The RE-AIM framework will be used to translate and evaluate the intervention in a "real world'' setting. 5) It is a disseminable model that, if effective, can used by public dental clinics throughout the US. ..
  66. Cognitive Processes in Smoking Cessation
    Andrew Waters; Fiscal Year: 2009
    ..Thus, results from this study may help us to identify individuals who are high risk for an early relapse, and facilitate the development of smoking cessation interventions. ..
  67. Tobacco Quitlines: An Adjunct to Dental Interventions
    Judith Gordon; Fiscal Year: 2006
    ..In addition, we will conduct an economic analysis to determine the relative cost effectiveness of each intervention. ..