marijuana abuse

Summary

Summary: The excessive use of marijuana with associated psychological symptoms and impairment in social or occupational functioning.

Top Publications

  1. ncbi Dose-related neurocognitive effects of marijuana use
    K I Bolla
    Department of Neurology, Johns Hopkins University School of Medicine, Hopkins Bayview Research Campus, Baltimore, MD 21224, USA
    Neurology 59:1337-43. 2002
  2. ncbi Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review
    Theresa H M Moore
    Academic Unit of Psychiatry, University of Bristol, Bristol, UK
    Lancet 370:319-28. 2007
  3. pmc Cannabinoid receptor 1 gene polymorphisms and marijuana misuse interactions on white matter and cognitive deficits in schizophrenia
    Beng Choon Ho
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 5224, USA
    Schizophr Res 128:66-75. 2011
  4. ncbi Cannabis and the brain
    Leslie Iversen
    Department of Pharmacology, University of Oxford, Oxford, UK
    Brain 126:1252-70. 2003
  5. ncbi Regional brain abnormalities associated with long-term heavy cannabis use
    Murat Yucel
    MAPS, ORYGEN Research Centre, 35 Poplar Rd, Melbourne, Victoria, Australia
    Arch Gen Psychiatry 65:694-701. 2008
  6. ncbi Grey matter alterations associated with cannabis use: results of a VBM study in heavy cannabis users and healthy controls
    Janna Cousijn
    ADAPT lab, Department of Psychology, University of Amsterdam, The Netherlands
    Neuroimage 59:3845-51. 2012
  7. ncbi Lower Risk Cannabis use Guidelines for Canada (LRCUG): a narrative review of evidence and recommendations
    Benedikt Fischer
    Centre for Applied Research in Mental Health and Addiction, Faculty of Health Sciences, Simon Fraser University, Vancouver, BC
    Can J Public Health 102:324-7. 2011
  8. ncbi Effects of cannabis use on outcomes of psychotic disorders: systematic review
    Stanley Zammit
    Academic Unit of Psychiatry, University of Bristol, UK
    Br J Psychiatry 193:357-63. 2008
  9. ncbi Cannabis use and psychosocial adjustment in adolescence and young adulthood
    David M Fergusson
    Christchurch Health and Development Study, Deaprtment of Psychological Medicine, Christchurch School of Medicine, New Zealand
    Addiction 97:1123-35. 2002
  10. pmc Toward a global view of alcohol, tobacco, cannabis, and cocaine use: findings from the WHO World Mental Health Surveys
    Louisa Degenhardt
    National Drug and Alcohol Research Centre, University of New South Wales, Sydney, New South Wales, Australia
    PLoS Med 5:e141. 2008

Detail Information

Publications298 found, 100 shown here

  1. ncbi Dose-related neurocognitive effects of marijuana use
    K I Bolla
    Department of Neurology, Johns Hopkins University School of Medicine, Hopkins Bayview Research Campus, Baltimore, MD 21224, USA
    Neurology 59:1337-43. 2002
    ..Although about 7 million people in the US population use marijuana at least weekly, there is a paucity of scientific data on persistent neurocognitive effects of marijuana use...
  2. ncbi Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review
    Theresa H M Moore
    Academic Unit of Psychiatry, University of Bristol, Bristol, UK
    Lancet 370:319-28. 2007
    ..We systematically reviewed the evidence pertaining to cannabis use and occurrence of psychotic or affective mental health outcomes...
  3. pmc Cannabinoid receptor 1 gene polymorphisms and marijuana misuse interactions on white matter and cognitive deficits in schizophrenia
    Beng Choon Ho
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 5224, USA
    Schizophr Res 128:66-75. 2011
    ..Almost a quarter of the sample met DSM marijuana abuse (14%) or dependence (8%) criteria...
  4. ncbi Cannabis and the brain
    Leslie Iversen
    Department of Pharmacology, University of Oxford, Oxford, UK
    Brain 126:1252-70. 2003
    ..Medicines based on drugs that enhance the function of endocannabinoids may offer novel therapeutic approaches in the future...
  5. ncbi Regional brain abnormalities associated with long-term heavy cannabis use
    Murat Yucel
    MAPS, ORYGEN Research Centre, 35 Poplar Rd, Melbourne, Victoria, Australia
    Arch Gen Psychiatry 65:694-701. 2008
    ..Cannabis is the most widely used illicit drug in the developed world. Despite this, there is a paucity of research examining its long-term effect on the human brain...
  6. ncbi Grey matter alterations associated with cannabis use: results of a VBM study in heavy cannabis users and healthy controls
    Janna Cousijn
    ADAPT lab, Department of Psychology, University of Amsterdam, The Netherlands
    Neuroimage 59:3845-51. 2012
    ..Differential patterns of structural changes for various cannabis use levels imply that alterations in brain structure are associated with specific characteristics of cannabis use and dependence...
  7. ncbi Lower Risk Cannabis use Guidelines for Canada (LRCUG): a narrative review of evidence and recommendations
    Benedikt Fischer
    Centre for Applied Research in Mental Health and Addiction, Faculty of Health Sciences, Simon Fraser University, Vancouver, BC
    Can J Public Health 102:324-7. 2011
    ..The objective of this paper was to develop 'Lower Risk Cannabis Use Guidelines' (LRCUG) based on research evidence on the adverse health effects of cannabis and factors that appear to modify the risk of these harms...
  8. ncbi Effects of cannabis use on outcomes of psychotic disorders: systematic review
    Stanley Zammit
    Academic Unit of Psychiatry, University of Bristol, UK
    Br J Psychiatry 193:357-63. 2008
    ..It is unclear if research findings support clinical opinion that cannabis use leads to worse outcomes in people with psychosis, or whether this impression is confounded by other factors...
  9. ncbi Cannabis use and psychosocial adjustment in adolescence and young adulthood
    David M Fergusson
    Christchurch Health and Development Study, Deaprtment of Psychological Medicine, Christchurch School of Medicine, New Zealand
    Addiction 97:1123-35. 2002
    ..To examine the associations between frequency of cannabis use and psychosocial outcomes in adolescence/young adulthood...
  10. pmc Toward a global view of alcohol, tobacco, cannabis, and cocaine use: findings from the WHO World Mental Health Surveys
    Louisa Degenhardt
    National Drug and Alcohol Research Centre, University of New South Wales, Sydney, New South Wales, Australia
    PLoS Med 5:e141. 2008
    ..This paper describes such data from the first 17 countries participating in the World Health Organization's (WHO's) World Mental Health (WMH) Survey Initiative...
  11. ncbi Neuroimaging in cannabis use: a systematic review of the literature
    R Martin-Santos
    Section of Neuroimaging, PO67 Division of Psychological Medicine, Institute of Psychiatry, King s College London, UK
    Psychol Med 40:383-98. 2010
    ..We conducted a systematic review to assess the evidence for specific effects of cannabis on brain structure and function. The review focuses on the cognitive changes associated with acute and chronic use of the drug...
  12. ncbi Greater white and grey matter changes associated with early cannabis use in adolescent-onset schizophrenia (AOS)
    A James
    Highfield Adolescent Unit, Warneford Hospital, Oxford, United Kingdom
    Schizophr Res 128:91-7. 2011
    ..Cannabis use is associated with a higher risk of schizophrenia, however, its specific long-term effect on the structure of the brain of adolescent-onset schizophrenic patients remains unclear...
  13. ncbi Adverse health effects of non-medical cannabis use
    Wayne Hall
    School of Population Health, University of Queensland, Herston, QLD, Australia
    Lancet 374:1383-91. 2009
    ....
  14. ncbi The chronic effects of cannabis on memory in humans: a review
    Nadia Solowij
    School of Psychology, University of Wollongong, Australia
    Curr Drug Abuse Rev 1:81-98. 2008
    ..The precise nature of memory deficits in cannabis users, their neural substrates and manifestation requires much further exploration through a variety of behavioural, functional brain imaging, prospective and genetic studies...
  15. pmc Marijuana craving in the brain
    Francesca M Filbey
    The MIND Research Network, 1101 Yale Boulevard, Albuquerque, NM 87106, USA
    Proc Natl Acad Sci U S A 106:13016-21. 2009
    ..These findings may inform the development of treatment strategies for cannabis dependence...
  16. pmc Dopamine release in chronic cannabis users: a [11c]raclopride positron emission tomography study
    Nina B L Urban
    New York State PsychiatricInstitute, Department of Psychiatry, 1051 Riverside Drive, New York, NY 10032, USA
    Biol Psychiatry 71:677-83. 2012
    ....
  17. ncbi The Cannabis Withdrawal Scale development: patterns and predictors of cannabis withdrawal and distress
    David J Allsop
    National Cannabis Prevention and Information Centre, University of New South Wales, Sydney 2031, Australia
    Drug Alcohol Depend 119:123-9. 2011
    ..The aim is to develop and test the psychometrics of the Cannabis Withdrawal Scale and use it to explore predictors of cannabis withdrawal...
  18. ncbi Gyrification brain abnormalities associated with adolescence and early-adulthood cannabis use
    Ignacio Mata
    Department of Psychiatry, University Hospital Marques de Valdecilla, School of Medicine, University of Cantabria, IFIMAV, Santander, Spain
    Brain Res 1317:297-304. 2010
    ....
  19. pmc White matter integrity in adolescents with histories of marijuana use and binge drinking
    J Jacobus
    SDSU UCSD Joint Doctoral Program in Clinical Psychology, USA
    Neurotoxicol Teratol 31:349-55. 2009
    ..Detection of white matter alterations may have implications in identifying early cognitive dysfunction in substance using adolescents...
  20. pmc Cannabis use and the course of schizophrenia: 10-year follow-up after first hospitalization
    Daniel J Foti
    Department of Psychology, Stony Brook University, Stony Brook, NY 11794 2500, USA
    Am J Psychiatry 167:987-93. 2010
    ..The authors examined the relationship between cannabis use and the course of illness in schizophrenia over 10 years of follow-up after first psychiatric hospitalization...
  21. pmc Neural correlates of verbal learning in adolescent alcohol and marijuana users
    Alecia Dager Schweinsburg
    Yale University, Department of Psychiatry, New Haven, CT, USA
    Addiction 106:564-73. 2011
    ..In this study, we characterize brain response during verbal learning among adolescent users of alcohol and marijuana...
  22. ncbi Effects of frequent cannabis use on hippocampal activity during an associative memory task
    Gerry Jager
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, A 01 126, University Medical Center, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Eur Neuropsychopharmacol 17:289-97. 2007
    ..Therefore, lower brain activation may not signify neurocognitive impairment, but could be the expression of a non-cognitive variable related to frequent cannabis use, for example changes in cerebral perfusion or differences in vigilance...
  23. ncbi A randomized controlled trial of brief cognitive-behavioral interventions for cannabis use disorder
    J Copeland
    National Drug and Alcohol Research Centre, University of New South Wales, Sydney 2052, Australia
    J Subst Abuse Treat 21:55-64; discussion 65-6. 2001
    ..This study supports the attractiveness and effectiveness of individual CBT interventions for cannabis use disorders and the need for multisite replication trials...
  24. ncbi From first drug use to drug dependence; developmental periods of risk for dependence upon marijuana, cocaine, and alcohol
    Fernando A Wagner
    Department of Mental Hygiene, Johns Hopkins University, Bloomberg School of Public Health, Electronic Collaboratory for Investigations about Drugs ELCID Rm 893, 624 N Broadway, Baltimore, MD 21205, USA
    Neuropsychopharmacology 26:479-88. 2002
    ..For marijuana and alcohol, there is a more insidious onset of the drug dependence syndrome...
  25. ncbi Dorsolateral prefrontal cortex N-acetylaspartate/total creatine (NAA/tCr) loss in male recreational cannabis users
    Derik Hermann
    Central Institute of Mental Health, Mannheim, Germany
    Biol Psychiatry 61:1281-9. 2007
    ..Cannabinoids present neurotoxic and neuroprotective properties in in vitro studies, inconsistent alterations in human neuroimaging studies, neuropsychological deficits, and an increased risk for psychotic episodes...
  26. pmc Cannabis use in adolescence and risk for adult psychosis: longitudinal prospective study
    Louise Arseneault
    SGDP Research Centre, King s College, London
    BMJ 325:1212-3. 2002
  27. ncbi Cannabis and schizophrenia: model projections of the impact of the rise in cannabis use on historical and future trends in schizophrenia in England and Wales
    Matthew Hickman
    Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol, UK
    Addiction 102:597-606. 2007
    ..To estimate long-term trends in cannabis use and projections of schizophrenia assuming a causal relation between cannabis use and schizophrenia...
  28. pmc Neurochemistry of drug action: insights from proton magnetic resonance spectroscopic imaging and their relevance to addiction
    Stephanie C Licata
    Behavioral Psychopharmacology Research Laboratory, McLean Hospital Harvard Medical School, Belmont, Massachusetts 02478, USA
    Ann N Y Acad Sci 1187:148-71. 2010
    ....
  29. pmc The impact of substance use on brain structure in people at high risk of developing schizophrenia
    Killian A Welch
    Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh EH10 5HF, UK
    Schizophr Bull 37:1066-76. 2011
    ..A family history of schizophrenia may render the brain particularly sensitive to the risk-modifying effects of these substances...
  30. ncbi Cannabis use and brain structural alterations in first episode schizophrenia--a region of interest, voxel based morphometric study
    Srihari S Bangalore
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA, 15213 USA
    Schizophr Res 99:1-6. 2008
    ..The results suggest that cannabis use may be associated with altered brain structure, in particular regions rich in CB1 receptors. These findings need to be confirmed by larger, prospective studies...
  31. pmc The impact of cannabis use on cognitive functioning in patients with schizophrenia: a meta-analysis of existing findings and new data in a first-episode sample
    Murat Yucel
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, National Neuroscience Facility, Alan Gilbert Building, 161 Barry Street, Carlton South, Victoria 3053, Australia
    Schizophr Bull 38:316-30. 2012
    ....
  32. ncbi Computer-based psychological treatment for comorbid depression and problematic alcohol and/or cannabis use: a randomized controlled trial of clinical efficacy
    Frances J Kay-Lambkin
    Centre for Brain and Mental Health Research, University of Newcastle, Newcastle, NSW, Australia
    Addiction 104:378-88. 2009
    ..To evaluate computer- versus therapist-delivered psychological treatment for people with comorbid depression and alcohol/cannabis use problems...
  33. ncbi Health consequences of illegal drug use
    Chuan Yu Chen
    Division of Mental Health and Substance Abuse Research, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli County, Taiwan
    Curr Opin Psychiatry 22:287-92. 2009
    ..The aim of this article is to review recent research on the health consequences of illegal drug use and possible risk factors, with a particular focus on prospective evidence...
  34. ncbi Effect of long-term cannabis use on axonal fibre connectivity
    Andrew Zalesky
    Melbourne Neuropsychiatry Centre, The University of Melbourne and Melbourne Health, Melbourne, 3053, Australia
    Brain 135:2245-55. 2012
    ..Our findings indicate long-term cannabis use is hazardous to the white matter of the developing brain. Delaying the age at which regular use begins may minimize the severity of microstructural impairment...
  35. ncbi Recent-onset schizophrenia and adolescent cannabis use: MRI evidence for structural hyperconnectivity?
    Bart D Peters
    Department of Psychiatry, Academic Medical Center, Amsterdam, The Netherlands
    Psychopharmacol Bull 42:75-88. 2009
    ..Further studies are necessary to assess the effect of adolescent cannabis and other illicit drug use on brain white matter in schizophrenia...
  36. ncbi Cannabis use and callosal white matter structure and integrity in recent-onset schizophrenia
    Nienke Dekker
    Department of Psychiatry, Academic Medical Centre, University of Amsterdam, Meibergdreef 5, 1105 AZ Amsterdam, The Netherlands
    Psychiatry Res 181:51-6. 2010
    ....
  37. pmc Functional connectivity in brain networks underlying cognitive control in chronic cannabis users
    Ian H Harding
    Department of Psychiatry, Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health, Melbourne, Vic, Australia
    Neuropsychopharmacology 37:1923-33. 2012
    ....
  38. ncbi Cannabis dependence and psychotic symptoms in young people
    D M Fergusson
    Christchurch Health and Development Study, Department of Psychological Medicine, Christchurch Medical School, Christchurch, New Zealand
    Psychol Med 33:15-21. 2003
    ....
  39. ncbi Neurocognitive performance during acute THC intoxication in heavy and occasional cannabis users
    J G Ramaekers
    Department of Neuropsychology and Psychopharmacology, Faculty of Psychology, Maastricht University, Maastricht, The Netherlands
    J Psychopharmacol 23:266-77. 2009
    ..These data indicate that cannabis use history strongly determines the behavioural response to single doses of THC...
  40. pmc Impaired error awareness and anterior cingulate cortex hypoactivity in chronic cannabis users
    Robert Hester
    Department of Psychology, University of Melbourne, Melbourne, Victoria, Australia
    Neuropsychopharmacology 34:2450-8. 2009
    ....
  41. pmc Functional MRI of inhibitory processing in abstinent adolescent marijuana users
    Susan F Tapert
    VA San Diego Healthcare System, 3350 La Jolla Village Drive 116B, San Diego, CA 92161, USA
    Psychopharmacology (Berl) 194:173-83. 2007
    ..We hypothesized that brain activation during a go/no-go task would show persistent abnormalities in adolescent marijuana users after 28 days of abstinence...
  42. ncbi Cerebellar white-matter changes in cannabis users with and without schizophrenia
    N Solowij
    School of Psychology, University of Wollongong, Australia
    Psychol Med 41:2349-59. 2011
    ..We examined cerebellar grey and white matter in cannabis users with and without schizophrenia...
  43. ncbi Association between cannabis use and psychosis-related outcomes using sibling pair analysis in a cohort of young adults
    John McGrath
    Queensland Brain Institute, University of Queensland, St Lucia, Queensland, Australia
    Arch Gen Psychiatry 67:440-7. 2010
    ..The use of sibling pair analysis reduces the influence of unmeasured residual confounding...
  44. ncbi Altered brain tissue composition in heavy marijuana users
    John A Matochik
    Intramural Research Program, Neuroimaging Research Branch, National Institute on Drug Abuse, NIH DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224 6823, USA
    Drug Alcohol Depend 77:23-30. 2005
    ..045). Our preliminary results suggest evidence of possible structural differences in the brain of heavy marijuana users, and localize regions for further investigation of the effects of marijuana in the brain...
  45. ncbi Cognitive functioning of long-term heavy cannabis users seeking treatment
    Nadia Solowij
    National Drug and Alcohol Research Centre, University of New South Wales, Sydney, NSW 2052, Australia
    JAMA 287:1123-31. 2002
    ..Cognitive impairments are associated with long-term cannabis use, but the parameters of use that contribute to impairments and the nature and endurance of cognitive dysfunction remain uncertain...
  46. pmc Prospective cohort study of cannabis use, predisposition for psychosis, and psychotic symptoms in young people
    Cecile Henquet
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, PO Box 616, 6200 MD Maastricht, Netherlands
    BMJ 330:11. 2005
    ..To investigate the relation between cannabis use and psychotic symptoms in individuals with above average predisposition for psychosis who first used cannabis during adolescence...
  47. pmc Cannabis intoxication and fatal road crashes in France: population based case-control study
    Bernard Laumon
    French National Institute for Transport and Safety Research INRETS, Epidemiological Research and Surveillance Unit in Transport, Occupation and Environment UMRESTTE, 25 Avenue François Mitterrand, F 69675 Bron Cedex
    BMJ 331:1371. 2005
    ..To evaluate the relative risk of being responsible for a fatal crash while driving under the influence of cannabis, the prevalence of such drivers within the driving population, and the corresponding share of fatal crashes...
  48. ncbi Reduced memory and attention performance in a population-based sample of young adults with a moderate lifetime use of cannabis, ecstasy and alcohol
    F Indlekofer
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, Germany
    J Psychopharmacol 23:495-509. 2009
    ..These effects are relatively small; however, it must be kept in mind that this study focussed on assessing young adults with moderate drug use from a population-based study...
  49. ncbi Adolescent cannabis users at 24 years: trajectories to regular weekly use and dependence in young adulthood
    Wendy Swift
    National Drug and Alcohol Research Centre, University of New South Wales, Australia
    Addiction 103:1361-70. 2008
    ..To examine the association between cannabis use by 18 years and problematic cannabis use at 24 years, considering possible mediating and confounding factors...
  50. ncbi Differences in regional brain metabolism associated with marijuana abuse in methamphetamine abusers
    Bradley Voytek
    Department of Psychiatry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90024, USA
    Synapse 57:113-5. 2005
  51. ncbi A prototype screening instrument for cannabis use disorder: the Cannabis Use Disorders Identification Test (CUDIT) in an alcohol-dependent clinical sample
    Simon J Adamson
    National Addiction Center, Department of Psychological Medicine, Christchurch School of Medicine, Christchurch, New Zealand
    Drug Alcohol Rev 22:309-15. 2003
    ..8% and sensitivity of 60.0% for 80 or more cannabis use-days. These results indicate the viability of a screening measure for identifying cannabis use disorder in at risk populations...
  52. pmc Altered affective response in marijuana smokers: an FMRI study
    Staci A Gruber
    Cognitive Neuroimaging Laboratory, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Drug Alcohol Depend 105:139-53. 2009
    ....
  53. pmc Diffusion abnormalities in adolescents and young adults with a history of heavy cannabis use
    Manzar Ashtari
    The Children s Hospital of Philadelphia, Philadelphia, PA, United States
    J Psychiatr Res 43:189-204. 2009
    ....
  54. pmc Increased ventral striatal BOLD activity during non-drug reward anticipation in cannabis users
    Liam Nestor
    School of Psychology and Institute of Neuroscience, Trinity College Dublin, Ireland
    Neuroimage 49:1133-43. 2010
    ....
  55. ncbi Family-based analysis of genetic variation underlying psychosis-inducing effects of cannabis: sibling analysis and proband follow-up
    Ruud van Winkel
    Department of Psychiatry and Psychology, School of Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands
    Arch Gen Psychiatry 68:148-57. 2011
    ..Individual differences exist in sensitivity to the psychotomimetic effect of cannabis; the molecular genetic basis underlying differential sensitivity remains elusive...
  56. ncbi Adolescent brain maturation, the endogenous cannabinoid system and the neurobiology of cannabis-induced schizophrenia
    Matthijs G Bossong
    Rudolf Magnus Institute of Neuroscience, Department of Neurology and Neurosurgery, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Prog Neurobiol 92:370-85. 2010
    ....
  57. ncbi Parietal lobe volume deficits in adolescents with schizophrenia and adolescents with cannabis use disorders
    Sanjiv Kumra
    University of Minnesota, USA
    J Am Acad Child Adolesc Psychiatry 51:171-80. 2012
    ..This study characterized cerebral cortical gray matter structure in adolescents in regions of interest (ROIs) that have been implicated in EOS and cannabis use disorders (CUD)...
  58. ncbi Evidence of increased activation underlying cognitive control in ecstasy and cannabis users
    Gloria M P Roberts
    School of Psychology and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
    Neuroimage 52:429-35. 2010
    ....
  59. ncbi Brain imaging study of the acute effects of Delta9-tetrahydrocannabinol (THC) on attention and motor coordination in regular users of marijuana
    Aviv Weinstein
    Department of Nuclear Medicine, Sourasky Medical Center, Tel Aviv, Israel
    Psychopharmacology (Berl) 196:119-31. 2008
    ..In both sessions, a virtual reality maze task was performed during the FDG uptake period...
  60. pmc One-year follow-up evaluation of the Project Towards No Drug Abuse (TND) dissemination trial
    Louise A Rohrbach
    Institute for Health Promotion and Disease Prevention Research, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Alhambra, CA 91803, USA
    Prev Med 51:313-9. 2010
    ....
  61. pmc The influence of recency of use on fMRI response during spatial working memory in adolescent marijuana users
    Alecia Dager Schweinsburg
    Yale University, Department of Psychiatry, New Haven, CT, USA
    J Psychoactive Drugs 42:401-12. 2010
    ....
  62. ncbi Early-onset cannabis use and cognitive deficits: what is the nature of the association?
    Harrison G Pope
    Department of Psychiatry, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Drug Alcohol Depend 69:303-10. 2003
    ..Individuals who initiate cannabis use at an early age, when the brain is still developing, might be more vulnerable to lasting neuropsychological deficits than individuals who begin use later in life...
  63. ncbi Marijuana use and cessation of tobacco smoking in adults from a community sample
    Daniel E Ford
    Department of Medicine, The Johns Hopkins University School of Medicine, 2024 E Monument Street, Suite 2 500, Baltimore, MD, USA
    Drug Alcohol Depend 67:243-8. 2002
    ..Clinicians working with patients who are trying to stop tobacco smoking may be aided by routinely assessing marijuana use history, particularly with the recent increase in co-smoking of marijuana and tobacco...
  64. pmc Medial temporal structures and memory functions in adolescents with heavy cannabis use
    Manzar Ashtari
    Department of Radiology, Children s Hospital of Philadelphia, Philadelphia, PA 19102, USA
    J Psychiatr Res 45:1055-66. 2011
    ....
  65. pmc Altered prefrontal and insular cortical thickness in adolescent marijuana users
    Melissa P Lopez-Larson
    The Brain Institute, University of Utah, Salt Lake City, UT 84108, USA
    Behav Brain Res 220:164-72. 2011
    ..This investigation applied cortical-surface based techniques to compare cortical thickness measures in MJ using adolescents compared to non-using controls...
  66. ncbi Testing hypotheses about the relationship between cannabis use and psychosis
    Louisa Degenhardt
    National Drug and Alcohol Research Centre, University of NSW, NSW 2052, Sydney, Australia
    Drug Alcohol Depend 71:37-48. 2003
    ..To model the impact of rising rates of cannabis use on the incidence and prevalence of psychosis under four hypotheses about the relationship between cannabis use and psychosis...
  67. ncbi Cannabis use and progressive cortical thickness loss in areas rich in CB1 receptors during the first five years of schizophrenia
    Monica Rais
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur Neuropsychopharmacol 20:855-65. 2010
    ..First-episode schizophrenia patients who use cannabis show a more pronounced cortical thinning than non-using patients in areas known for their high density of CB1 receptors, such as the ACC and the DLPFC...
  68. ncbi A controlled trial of an internet-based intervention program for cannabis users
    Hans Peter Tossmann
    delphi Gesellschaft für Forschung, Beratung und Projektentwicklung, Berlin, Germany
    Cyberpsychol Behav Soc Netw 14:673-9. 2011
    ..Despite limitations concerning the interpretation of the results, the intervention seems to offer an effective treatment option for persons with cannabis-related problems...
  69. pmc Cannabis withdrawal symptoms in non-treatment-seeking adult cannabis smokers
    Kenneth H Levin
    Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA
    Drug Alcohol Depend 111:120-7. 2010
    ..Cannabis withdrawal is not recognized in DSM-IV because of doubts about its clinical significance...
  70. ncbi Cannabis withdrawal among non-treatment-seeking adult cannabis users
    Marc L Copersino
    Clinical Pharmacology and Therapeutics Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224 6823, USA
    Am J Addict 15:8-14. 2006
    ....
  71. ncbi Promoting the implementation of an evidence-based intervention for adolescent marijuana abuse in community settings: testing the use of intensive quality assurance
    Scott W Henggeler
    Family Services Research Center, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    J Clin Child Adolesc Psychol 37:682-9. 2008
    ..Assurance (IQA) system to promote therapist implementation of contingency management (CM) for adolescent marijuana abuse. Participants included 30 therapists assigned to Workshop Only (WSO) versus IQA training conditions, and 70 ..
  72. ncbi Early reactions to cannabis predict later dependence
    David M Fergusson
    Christchurch Health and Development Study, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    Arch Gen Psychiatry 60:1033-9. 2003
    ..While there is a growing literature on the linkages between early subjective responses to nicotine and alcohol and later risks of nicotine or alcohol dependence, to date there has been no study of this issue in relation to cannabis...
  73. ncbi Deficits in learning and memory: parahippocampal hyperactivity and frontocortical hypoactivity in cannabis users
    Liam Nestor
    Department of Psychology and Institute of Neuroscience, Trinity College, University of Dublin, Ireland
    Neuroimage 40:1328-39. 2008
    ..Hypoactivity in frontal and temporal cortices, and relative hyperactivity in the parahippocampus identify functional deficits and compensatory processes in cannabis users...
  74. pmc Candidate genes for cannabis use disorders: findings, challenges and directions
    Arpana Agrawal
    Washington University School of Medicine, Department of Psychiatry, St Louis, MO 63110, USA
    Addiction 104:518-32. 2009
    ....
  75. ncbi An epidemiological perspective of substance use among high school pupils in rural KwaZulu-Natal
    M Taylor
    Department of Community Health, Nelson R Mandela School of Medicine, University of Natal, Durban
    S Afr Med J 93:136-40. 2003
    ..To investigate prevalence and the factors influencing substance use among rural high school pupils in KwaZulu-Natal in order to develop and implement intervention programmes...
  76. ncbi Selective processing of cannabis cues in regular cannabis users
    Matt Field
    School of Psychology, University of Liverpool, Liverpool L69 7ZA, UK
    Drug Alcohol Depend 85:75-82. 2006
    ..Results are generally consistent with previous findings from tobacco smokers and heavy drinkers, and the implications for incentive-motivational theories of addiction are discussed...
  77. ncbi The role of cannabis in cognitive functioning of patients with schizophrenia
    Thomas Schnell
    Department of Psychiatry and Psychotherapy, University Hospital of Cologne, Kerpener Str 62, 50924, Cologne, Germany
    Psychopharmacology (Berl) 205:45-52. 2009
    ..Surprisingly, some small recent studies reported better cognitive performance in SCH patients with comorbid cannabis use disorders (SCH + CUD) compared to other SCH patients...
  78. ncbi Escalation of drug use in early-onset cannabis users vs co-twin controls
    Michael T Lynskey
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    JAMA 289:427-33. 2003
    ..Previous studies have reported that early initiation of cannabis (marijuana) use is a significant risk factor for other drug use and drug-related problems...
  79. pmc Increased cortical inhibition deficits in first-episode schizophrenia with comorbid cannabis abuse
    Thomas Wobrock
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Von Siebold Strasse 5, 37075 Gottingen, Germany
    Psychopharmacology (Berl) 208:353-63. 2010
    ..Studies on cortical excitability comparing SZ patients with and without comorbid substance abuse are lacking...
  80. ncbi The relationship between cannabis use and other substance use in the general population
    L Degenhardt
    National Drug and Alcohol Research Centre, University of NSW, Sydney 2052, Australia
    Drug Alcohol Depend 64:319-27. 2001
    ..The high likelihood of other substance use and substance use disorders needs to be considered among persons seeking treatment for cannabis use problems...
  81. ncbi Marijuana abstinence effects in marijuana smokers maintained in their home environment
    A J Budney
    Department of Psychiatry, The University of Vermont, 54 W Twin Oaks Terr, Suite 9, S Burlington, VT 05403, USA
    Arch Gen Psychiatry 58:917-24. 2001
    ..This controlled outpatient study examined the reliability and specificity of the abstinence effects that occur when daily marijuana users abruptly stop smoking marijuana...
  82. ncbi The marijuana withdrawal syndrome: diagnosis and treatment
    Margaret Haney
    New York State Psychiatric Institute, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Curr Psychiatry Rep 7:360-6. 2005
    ..The objective of this review is to update clinicians on the current state of marijuana research and to describe features of marijuana withdrawal to facilitate the diagnosis and treatment of cannabis use disorders...
  83. pmc White-matter abnormalities in adolescents with long-term inhalant and cannabis use: a diffusion magnetic resonance imaging study
    Murat Yucel
    Orygen Youth Health Research Centre, 35 Poplar Rd, Parkville, Victoria 3052, Australia
    J Psychiatry Neurosci 35:409-12. 2010
    ....
  84. pmc The consumption of khat and other drugs in Somali combatants: a cross-sectional study
    Michael Odenwald
    PLoS Med 4:e341. 2007
    ....
  85. ncbi The effect of cannabis on the brain: can it cause brain anomalies that lead to increased risk for schizophrenia?
    Lynn E DeLisi
    New York University, New York, NY 10016, USA
    Curr Opin Psychiatry 21:140-50. 2008
    ..This review explores what is known about the association of cannabis with schizophrenia, its effects on the brain, and whether the brain changes known to be present in schizophrenia could be caused by cannabis and thus lead to a psychosis...
  86. pmc The use of contingency management and motivational/skills-building therapy to treat young adults with marijuana dependence
    Kathleen M Carroll
    Division of Substance Abuse, Yale University School of Medicine, West Haven, CT 06516, USA
    J Consult Clin Psychol 74:955-66. 2006
    ..Participants assigned to MET/CBT continued to reduce the frequency of their marijuana use through a 6-month follow-up...
  87. ncbi Cannabis use prior to first onset psychosis predicts spared neurocognition at 10-year follow-up
    John Stirling
    Department of Psychology and Speech Pathology, Manchester Metropolitan University, Elizabeth Gaskell Building, Hathersage Road, M13 0JA, UK
    Schizophr Res 75:135-7. 2005
    ..These findings are briefly discussed in relation to other casual factors in psychosis...
  88. pmc Cannabis withdrawal in adolescent treatment seekers
    Ryan Vandrey
    Department of Psychology and Psychiatry, University of Vermont, 54 W Twin Oaks Terrace, Suite 12, S Burlington, VT 05403, USA
    Drug Alcohol Depend 78:205-10. 2005
    ..Addiction 94, 1311-1322]. Further research is needed to elucidate associations between cannabis withdrawal effects, the initiation of cessation attempts, and relapse...
  89. ncbi The mediation role of licit drugs in the influence of socializing on cannabis use among adolescents: A quantitative approach
    Aurélie Mayet
    INSERM U, Paris Sud Innovation Group in Adolescent Mental Health, Maison de Solenn, Paris, France
    Addict Behav 35:890-5. 2010
    ..Thus, the gateway effects of tobacco and alcohol require further exploration in relation to simultaneous polysubstance use...
  90. pmc Individual and additive effects of the CNR1 and FAAH genes on brain response to marijuana cues
    Francesca M Filbey
    The MIND Research Network, Albuquerque, NM 87106, USA
    Neuropsychopharmacology 35:967-75. 2010
    ....
  91. ncbi Chronic effects of cannabis use on the human reward system: an fMRI study
    Hendrika H Van Hell
    Rudolf Magnus Institute of Neuroscience, Department of Neurology and Neurosurgery, Section Brain Function and Plasticity, University Medical Center, Utrecht, The Netherlands
    Eur Neuropsychopharmacol 20:153-63. 2010
    ..Our findings imply that chronic cannabis use as well as nicotine, may cause an altered brain response to rewarding stimuli...
  92. ncbi Neuropsychological deficits in long-term frequent cannabis users
    Lambros Messinis
    Department of Neurology, University Hospital Patras, Patras, Greece
    Neurology 66:737-9. 2006
    ..LT and ST users had a higher proportion of deficits on verbal fluency, verbal memory, attention, and psychomotor speed. Specific cognitive domains appear to deteriorate with increasing years of heavy frequent cannabis use...
  93. ncbi Conceptual issues in behavioral teratology and their application in determining long-term sequelae of prenatal marihuana exposure
    P A Fried
    Department of Psychology, Carleton University, Ottawa, Ontario, Canada
    J Child Psychol Psychiatry 43:81-102. 2002
    ....
  94. ncbi Abnormal brain activity in prefrontal brain regions in abstinent marijuana users
    Dana A Eldreth
    Department of Neurology, Johns Hopkins University School of Medicine, Bayview Medical Center, 4940 Eastern Avenue, Baltimore, MD 21224, USA
    Neuroimage 23:914-20. 2004
    ..These differences in brain activity may be a common denominator in the evolution of maladaptive behaviors such as substance abuse and other neuropsychiatric disorders...
  95. ncbi Does cannabis use affect prospective memory in young adults?
    Janice Bartholomew
    Cognition and Communication Research Centre, School of Psychology and Sport Science, Northumbria University, Newcastle upon Tyne, UK
    J Psychopharmacol 24:241-6. 2010
    ..The findings from the present study suggest that cannabis use has a detrimental effect on prospective memory ability in young adults but users may not be aware of these deficits...
  96. pmc Cannabis and psychosis/schizophrenia: human studies
    DEEPAK CYRIL D'SOUZA
    Schizophrenia Biological Research Center, Psychiatry Service, VA Connecticut Healthcare System, 116A, 950 Campbell Avenue, West Haven, CT 06516, USA
    Eur Arch Psychiatry Clin Neurosci 259:413-31. 2009
    ..However, novel hypotheses including the role of cannabinoids on neurodevelopmental processes relevant to psychotic disorders are being studied...
  97. ncbi Adverse effects of cannabis on health: an update of the literature since 1996
    Harold Kalant
    Department of Pharmacology, Medical Sciences Building, University of Toronto, Toronto, ON, Canada M5S 1A8
    Prog Neuropsychopharmacol Biol Psychiatry 28:849-63. 2004
    ..In total, the evidence indicates that regular heavy use of cannabis carries significant risks for the individual user and for the health care system...
  98. pmc Volumetric MRI study of brain in children with intrauterine exposure to cocaine, alcohol, tobacco, and marijuana
    Michael J Rivkin
    Developmental Neuroimaging Laboratory, Department of Neurology, Childrens Hospital Boston and Harvard Medical School, Pavilion 154, 300 Longwood Ave, Boston, MA 02115, USA
    Pediatrics 121:741-50. 2008
    ..The objective of this study was to use volumetric MRI to study brain volumes in 10- to 14-year-old children with and without intrauterine exposure to cocaine, alcohol, cigarettes, or marijuana...
  99. ncbi The natural course of cannabis use, abuse and dependence during the first decades of life
    Axel Perkonigg
    Institute of Clinical Psychology and Psychotherapy, Technische Universitaet Dresden, Germany
    Addiction 103:439-49; discussion 450-1. 2008
    ..The current study estimated rates and risk factors associated with stability and variation in cannabis use patterns, cannabis abuse and cannabis dependence in a community sample over a 10-year period...
  100. ncbi Impact of cannabis and other drugs on age at onset of psychosis
    Ana Gonzalez-Pinto
    Department of Psychiatry, Santiago Apostol Hospital, CIBER SAM, Vitoria, Spain
    J Clin Psychiatry 69:1210-6. 2008
    ..The aim of this study was to investigate the relationship between age and cannabis use in patients with a first psychotic episode, and to analyze the mediating effect of comorbid use of other drugs and sex on age at onset of psychosis...
  101. pmc Reliability and validity of a short form of the Marijuana Craving Questionnaire
    Stephen J Heishman
    Intramural Research Program, National Institute on Drug Abuse, 251 Bayview Blvd, Baltimore, MD 21224, USA
    Drug Alcohol Depend 102:35-40. 2009
    ..For use in research and clinical settings, we constructed a 12-item version of the MCQ by selecting three items from each of the four factors that exhibited the greatest within-factor internal consistency (Cronbach's alpha coefficient)...

Research Grants64

  1. Smoked Marijuana Discrimination and Marijuana Choice in Humans: A Laboratory Mode
    Leslie H Lundahl; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Despite the high prevalence of marijuana abuse and dependence, there are no medications available to treat these important disorders and research on the ..
  2. PA-06-555 Senior Scientist Research and Mentorship Award (K05)
    GEORGE EDWARD WOODY; Fiscal Year: 2012
    ..in the Republic of Georgia, and a study of Concerta for reducing HIV risk in adolescents with ADHD and marijuana abuse or dependence in Brazil, helping develop guidelines for integrating addiction and HIV treatment in Russia, ..
  3. Cannabinoid effects on HIV/AIDS
    Patricia E Molina; Fiscal Year: 2010
    ..Findings from these studies will provide objective scientific evidence on the effects of chronic marijuana abuse and will provide critical information about the potential health consequences of cannabinoid use in ..
  4. Presynaptic Forms of Long-Term Plasticity in the CNS
    Pablo E Castillo; Fiscal Year: 2013
    ..plasticity is crucial not only a more realistic representation of neural function but also to identify how marijuana abuse may affect the brain, and ultimately, to develop novel therapeutic strategies targeting the endocannabinoid ..
  5. REACHING AND MOTIVATING CHANGE IN TEEN MARIJUANA SMOKERS
    DENISE D WALKER-SCHRAMM; Fiscal Year: 2013
    ..Two national epidemiological surveys conducted 10 years apart indicate that the prevalence of DSM-IV marijuana abuse and dependence diagnoses has significantly increased despite rates of past year use having remained stable...
  6. Citicoline-Induced Modulation of Cannabis Effects: Imaging &Mechanism of Action
    Scott E Lukas; Fiscal Year: 2012
    ..abstract_text> ..
  7. The Impact of Medical Marijuana in Metropolitan Denver
    ROBERT EDWIN BOOTH; Fiscal Year: 2013
    ..now has an estimated 100,000 medical marijuana patients, and this widespread use raises concerns about marijuana abuse, diversion and other consequences of use...
  8. Buspirone, Stress, and Attentional Bias to Marijuana Cues
    Scott D Lane; Fiscal Year: 2013
    ..Notably, stress is a well-documented predictor of marijuana abuse and marijuana relapse...
  9. Family Based Contingency Management for Adolescent Alcohol Abuse
    Catherine Stanger; Fiscal Year: 2011
    ..Although new outpatient family-based and contingency-management (CM) interventions for adolescent marijuana abuse have been developed, not one of them specifically targets adolescent primary alcohol users...
  10. The Neuroeconomics of Behavioral Therapies for Adolescent Substance Abuse
    Catherine Stanger; Fiscal Year: 2012
    ..studies investigating contingency- management (CM) based treatments "Behavioral Treatment of Adolescent Marijuana Abuse" (DA015186), and "Family Based Contingency Management for Adolescent Alcohol Abuse" (AA016917)...
  11. Marijuana Dependence Treatment PRN
    DENISE D WALKER SCHRAMM; Fiscal Year: 2010
    ..Two national epidemiological surveys conducted 10 years apart indicate that the prevalence of DSM-IV marijuana abuse and dependence diagnoses has significantly increased despite rates of past year use having remained stable...
  12. Imaging Studies in Neurotoxicity and Neurodevelopment
    Linda Chang; Fiscal Year: 2011
    ..The problems of Meth and marijuana abuse affect the underserved minorities, specifically Pacific islanders, and Asians, in Hawai'i more than ..
  13. A multilevel vulnerability study of substance abuse via CNV, brain activation and
    Jingyu Liu; Fiscal Year: 2010
    ..After independently conducting the multilevel vulnerability study on alcohol, nicotine, and marijuana abuse, the common pathways among them will be extracted...
  14. CONTROL OF ENDOCANNABINOID RELEASE IN VIVO
    Daniele Piomelli; Fiscal Year: 2003
    ..on the possible pathophysiological roles of the endogenous cannabinoid system, as well as on the mechanism of marijuana abuse. Moreover, by uncovering the neurochemical interactions between cocaine and the endogenous cannabinoids, our ..
  15. Integrative Risk Reduction and Treatment for Teen Substance Use Problems and PTSD
    Carla Kmett Danielson; Fiscal Year: 2013
    ..For example. research has indicated that adolescent CSA victims are over 3.5 times more likely to report marijuana abuse/dependence compared to non-CSA victims...
  16. MARIJUANA & DOPAMINE/ENKEPHALIN BRAIN REWARD SYSTEMS
    ELIOT GARDNER; Fiscal Year: 1992
    ..into fundamental brain mechanisms underlying marijuana's abuse potential, and to treatment possibilities for marijuana abuse. The health relatedness is clear, given that marijuana is the most widely used illicit drug in the United ..
  17. CANNABINOIDS AND THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS
    Laura Murphy; Fiscal Year: 2002
    The long-term objectives of this proposal are to advance our knowledge of the physiological effects of marijuana abuse and to elucidate the neuroendocrine function of the endogenous cannabinoid system...
  18. A multilevel vulnerability study of substance abuse via CNV, brain activation and
    Jingyu Liu; Fiscal Year: 2012
    ..After independently conducting the multilevel vulnerability study on alcohol, nicotine, and marijuana abuse, the common pathways among them will be extracted.
  19. Cannabinoid-Altered Vocal Development
    KENNETH M SODERSTROM; Fiscal Year: 2010
    ..songbirds and mammalian species, what we learn about the neural mechanisms of cannabinoid-altered sensory-motor vocal learning will likely prove relevant to the problem of human marijuana abuse that typically begins during adolescence.
  20. PRODUCTION ANALYSIS & DISTRIBUTION CANNABIS & MARIJUANA
    Mahmoud Elsohly; Fiscal Year: 2000
    The primary function of this contract is to provide materials to support research on marijuana abuse, its effects on psychological and physical development and its potential medicinal use...
  21. Astroglial Cells in Marijuana-Altered Synaptic Plasticity
    Chu Chen; Fiscal Year: 2009
    ..changes in synaptic circuits, and is expected to further our understanding of the molecular and cellular mechanisms underlying marijuana abuse-induced tolerance and alterations in synaptic plasticity and cognitive function.
  22. ELECTROPHYSIOLOGY OF CANNABINOID ACTION ON RAT BEHAVIORS
    Jing Yu Chang; Fiscal Year: 2001
    ..proposal is aimed at elucidating the fundamental neuronal mechanism(s) underlying the central effects of marijuana abuse with special emphasis on the neuronal processes involved in timing, sensory-motor integration, and learning ..
  23. Contingency management/adolescents with marijuana use disorders
    Therese Killeen; Fiscal Year: 2007
    ..program and provide preliminary data concerning the efficacy of contingency management for adolescents with marijuana abuse and dependence...
  24. Cannabinoid Effects on Development of a Learned Behavior
    KENNETH SODERSTROM; Fiscal Year: 2004
    ..A sharp increase in marijuana abuse by high school students over the last decade has been attributed to decreased perception of associated ..
  25. Adolescent Marijuana Abuse & Externalizing Problems
    CARRIE BOWMAN; Fiscal Year: 2003
    ..receiving substance abuse treatment, yet there is a dearth of research on adolescents seeking treatment for marijuana abuse or dependence. Research has shown that externalizing problems are frequently outcomes...
  26. Mood and Substance Use Among College Students
    Jeffrey Simons; Fiscal Year: 2003
    ..Better understanding of the etiological paths of substance use problems may be useful for early identification of individuals at risk for substance use problems and may inform the development of effective interventions. ..
  27. Self-control and alcohol problems: Psychological mechanisms
    Jeffrey S Simons; Fiscal Year: 2010
    ..To enhance understanding of alcohol disorder etiology, a theory-based, multi-level model of self control, goal-setting, and alcohol consumption and use disorder symptoms will be tested. ..
  28. Risk for Alcohol Problems Among College Students
    Jeffrey Simons; Fiscal Year: 2006
    ..Better understanding of the etiological paths to alcohol use problems may be useful for early identification of individuals at risk for alcohol use problems and may inform the development of effective interventions. ..
  29. Study of a Cannabinoid Receptor Interacting Protein
    JASON NIEHAUS; Fiscal Year: 2004
    ..In addition, further insight into the cannabinoid system may lead to a better understanding of marijuana abuse, tolerance and dependence.
  30. CLINICAL SIGNIFICANCE OF MARIJUANA WITHDRAWAL
    Alan Budney; Fiscal Year: 2006
    ..This information will also help decide whether pharmacological treatments for marijuana dependence focused on relieving withdrawal should be pursued. ..
  31. Medication Development for Marijuana Relapse
    Margaret Haney; Fiscal Year: 2008
    ..abstract_text> ..
  32. Development and Efficacy Test of Computerized Treatment for Marijuana Dependence
    ALAN JEFFREY BUDNEY; Fiscal Year: 2010
    ....
  33. NOVEL COCAINE PHARMACOTHERAPIES: LAB STUDIES
    Margaret Haney; Fiscal Year: 2003
    ....
  34. THC AND MARIJUANA--EFFECTS IN INDIVIDUALS WITH HIV/AIDS
    Margaret Haney; Fiscal Year: 2002
    ....
  35. BEHAVIORAL TREATMENT OF MARIJUANA DEPENDENCE
    Alan Budney; Fiscal Year: 2001
    ..Given the "novelty" of such programs, it is vital to our dissemination mission that we clearly establish the reliability and validity of their short and long-term efficacy. ..
  36. Atomoxetine Treatment for ADHD and Marijuana Dependence
    Aimee McRae Clark; Fiscal Year: 2006
    ..The project is designed to increase our knowledge of treatment options for patients with marijuana dependence, an area which has been under investigated. [unreadable] [unreadable]..
  37. Stress and Marijuana Cue-Elicited Craving and Reactivity
    Aimee McRae; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  38. ADOLESCENT MARIJUANA USE IN NATIVE AMERICANS
    Cindy Ehlers; Fiscal Year: 2008
    ..abstract_text> ..
  39. Alcoholism risk and protective factors in Trinidad
    Cindy Ehlers; Fiscal Year: 2006
    ..Study findings can be compared to similar studies being conducted in the US. We believe these studies will allow for the identification of risk and protective factors for alcoholism in these islands. [unreadable] [unreadable]..
  40. Neurobehavioral Consequences of Adolescent Alcohol
    Cindy Ehlers; Fiscal Year: 2008
    ..AIM 3: To investigate the neurochemical substrates underlying the lasting neurobehavioral consequences of adolescent ethanol exposure, with a focus on NMDA systems ..
  41. Career Training in Marijuana Dependence
    Aimee McRae; Fiscal Year: 2006
    ..Developing this well-rounded perspective and expertise in the area of cannabinoids and marijuana abuse and dependence is the aim of the training plan outlined...
  42. RISK FACTORS FOR ALCOHOLISM IN NATIVE AMERICANS
    Cindy Ehlers; Fiscal Year: 2006
    ..The identification of such variables may potentially be useful in the development of specific prevention and treatment programs for this population as well as other Native American tribes. ..
  43. Combined Pharmacotherapies for Cocaine Dependence
    Frances Levin; Fiscal Year: 2008
    ..3. To explore a set of related secondary outcomes (treatment retention, global functioning, and HIV risk behavior) as well as moderators and mediators potentially reflective of mechanism of action. [unreadable] [unreadable] [unreadable]..
  44. PREDICTORS OF ADOLESCENT ECSTASY USE IN THE NATIONAL SURVEY OF PARENTS AND YOUTH
    Silvia Martins; Fiscal Year: 2006
    ..Finally, we believe that our study will bring public health contributions to better understand potential determinants of ecstasy use. [unreadable] [unreadable]..
  45. Extended Release Mixed Amphetamine Salts for Adult ADHD and Cocaine Dependence
    Frances Rudnick Levin; Fiscal Year: 2010
    ..Here a nearly unique opportunity exists to treat two conditions, ADHD and cocaine dependence, with a single medication, hopefully leading to improved treated outcome in this difficult-to-treat population. ..
  46. TREATMENT OF ADULT ADHD IN METHADONE PATIENTS
    Frances Levin; Fiscal Year: 2002
    ..Overall, this proposal will provide a better understanding of the relationship between ADHD and substance abuse, better diagnostic evaluation, and improved pharmacologic treatment approaches for this sub-population. ..
  47. Childhood Determinants of Adolescent / Adult Drug Use
    Judith S Brook; Fiscal Year: 2010
    ..Identification of childhood and adolescent factors that can exacerbate the impact of substance use consequences on later adult functioning would provide additional information necessary for effective treatment efforts. ..
  48. Marijuana Dependence & Depression: Venlafaxine Treatment
    Frances Levin; Fiscal Year: 2006
    ..3. To examine the relationship between medication treatment, mood improvement, cognitive functioning and improvement in marijuana abuse using mediational analyses.
  49. Trends in Problems Related to Extramedical Use of Analgesics
    Silvia Martins; Fiscal Year: 2008
    ..It will contribute to the development of prevention, intervention and treatment for problem extramedical analgesic users. [unreadable] [unreadable] [unreadable] [unreadable]..
  50. METHYLPHENIDATE TREATMENT FOR COCAINE ABUSE AND ADHD
    Frances Levin; Fiscal Year: 2002
    ..2) To determine if sustained-release MPH is more effective than placebo in reducing ADHD symptoms in cocaine abusers with adult ADHD. 3) To determine if improvement in ADHD symptoms precedes a reduction in cocaine use. ..
  51. Marijuana Abusing ADHD Teens: Atomoxetine Treatment
    Frances Levin; Fiscal Year: 2004
    ..4. To examine the relationship between medication treatment, reduction in ADHD symptoms, and improvement in retention and/or progress in treatment using mediational analyses. ..
  52. Childhood Predictors and Consequences of Adult Smoking
    Judith Brook; Fiscal Year: 2008
    ..Identification of childhood and adolescent factors that can lessen or compensate for the impact of tobacco use on later functioning would provide additional aids for effective prevention and treatment efforts. ..
  53. Treatment Utilization for Alcohol-Related Problems
    Li Tzy Wu; Fiscal Year: 2002
    ....
  54. Cannabis and Other Illicit Drug Use: A Twin Study
    Michael Lynskey; Fiscal Year: 2009
    ..abstract_text> ..
  55. Sensory Processing Deficits in Cannabis Use
    PATRICK SKOSNIK; Fiscal Year: 2006
    ..Taken together, this data may serve to elucidate whether the known cognitive dysfunction observed in cannabis use is in part related to disturbances in early sensory information processing and/or neural synchronization. ..
  56. Individualized Assessment and Treatment for Alcoholism
    Mark Litt; Fiscal Year: 2007
    ..These results would have implications for our delivery of treatment, and for the validity of coping skills training for alcohol addiction. ..
  57. Brief Focused Treatment for TMD: Mechanisms of Action
    Mark Litt; Fiscal Year: 2007
    ..abstract_text> ..
  58. Inhalant Use/Dependence: Incidence and Comorbidity
    Li Tzy Wu; Fiscal Year: 2005
    ..Gaps in our knowledge of the natural course of inhalant use will be specified for future research. ..
  59. Cannabis Use, Abuse and Dependence: Exploring Phenotypes
    Michael Lynskey; Fiscal Year: 2008
    ..AIM 5: Based on these analyses, to formulate a model for unfolding of genetic influences on transitions in cannabis and the emergence of dependence symptoms. ..
  60. Correlates of Duration of Initial Untreated Psychosis
    MICHAEL COMPTON; Fiscal Year: 2008
    ..The overall aim of the research project is to provide an in-depth exploration of the potential causes and consequences of initially untreated psychosis among first-episode patients. ..
  61. Mechanisms of Change in Alcohol Treatment for Dually Diagnosed Youth
    Tammy Chung; Fiscal Year: 2008
    ..Results have important implications for improving the design and delivery of treatment provided to dually diagnosed adolescents. [unreadable] [unreadable] [unreadable]..
  62. The Effect of Cannabis Use on Human Cerebellar Function
    PATRICK SKOSNIK; Fiscal Year: 2008
    ..Project Narrative [unreadable] [unreadable] [unreadable]..
  63. Epdemiology of Non-Medical Prescription Anagesic Use
    Li Tzy Wu; Fiscal Year: 2009
    ..Such findings will be vital to policy makers in predicting the potential burden of NMPAU-related problems. ..
  64. DIAGNOSTIC CRITERIA FOR ADOLESCENT ALCOHOL USE DISORDERS
    Tammy Chung; Fiscal Year: 2005
    ..This award will provide a solid foundation for the applicant to become an independent investigator specializing in adolescent alcohol problems. ..