cocaine related disorders

Summary

Summary: Disorders related or resulting from use of cocaine.

Top Publications

  1. ncbi Evidence for addiction-like behavior in the rat
    Véronique Deroche-Gamonet
    INSERM U588, Laboratoire de Physiopathologie des Comportements, Bordeaux Institute for Neurosciences, University Victor Segalen Bordeaux 2, Domaine de Carreire, rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    Science 305:1014-7. 2004
  2. ncbi Cocaine seeking habits depend upon dopamine-dependent serial connectivity linking the ventral with the dorsal striatum
    David Belin
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
    Neuron 57:432-41. 2008
  3. ncbi Cocaine cues and dopamine in dorsal striatum: mechanism of craving in cocaine addiction
    Nora D Volkow
    National Institute on Alcohol Abuse and Alcoholism, Bethesda Maryland 20892, USA
    J Neurosci 26:6583-8. 2006
  4. ncbi Executive dysfunction in cocaine addiction: evidence for discordant frontal, cingulate, and cerebellar activity
    Robert Hester
    Department of Psychology and Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
    J Neurosci 24:11017-22. 2004
  5. ncbi Historical review: Molecular and cellular mechanisms of opiate and cocaine addiction
    Eric J Nestler
    Department of Psychiatry and Center for Basic Neuroscience The University of Texas Southwestern Medical Center 5323 Harry Hines Blvd, Dallas, TX 75390 9070, USA
    Trends Pharmacol Sci 25:210-8. 2004
  6. ncbi Understanding polydrug use: review of heroin and cocaine co-use
    Francesco Leri
    Center for Studies in Behavioural Neurobiology, Concordia University, Montreal, Montreal, Canada
    Addiction 98:7-22. 2003
  7. ncbi Dopamine release in the dorsal striatum during cocaine-seeking behavior under the control of a drug-associated cue
    Rutsuko Ito
    Department of Experimental Psychology, University of Cambridge, Cambridge, CB2 3EB, United Kingdom
    J Neurosci 22:6247-53. 2002
  8. ncbi Stroke in young adults who abuse amphetamines or cocaine: a population-based study of hospitalized patients
    Arthur N Westover
    Department of Psychiatry, Division of Epidemiology and Preventive Medicine, The University of Texas Southwestern Medical Center at Dallas, TX 75390, USA
    Arch Gen Psychiatry 64:495-502. 2007
  9. pmc Acute effects of cocaine on the neurobiology of cognitive control
    Hugh Garavan
    Institute of Neuroscience, School of Psychology, Trinity College Dublin, Dublin 2, Ireland
    Philos Trans R Soc Lond B Biol Sci 363:3267-76. 2008
  10. ncbi Escalation of cocaine self-administration does not depend on altered cocaine-induced nucleus accumbens dopamine levels
    Serge H Ahmed
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California, USA
    J Neurochem 86:102-13. 2003

Research Grants

  1. Behavioral correlates of fMRI response in cocaine users
    Rita Goldstein; Fiscal Year: 2006
  2. TREATMENT FOR DUALLY DEPENDENT METHADONE PATIENTS
    Nancy Petry; Fiscal Year: 2002
  3. Topiramate for alcohol and cocaine dependence
    Kyle Kampman; Fiscal Year: 2008
  4. Cocaine Withdrawal and Pharmacotherapy Response
    Mehmet Sofuoglu; Fiscal Year: 2010
  5. Progestrone and the Effects of Nicotine
    Mehmet Sofuoglu; Fiscal Year: 2006
  6. GABA Medications for Tobacco Addiction
    Mehmet Sofuoglu; Fiscal Year: 2009
  7. Medication Development for Marijuana Relapse
    Margaret Haney; Fiscal Year: 2008
  8. NOVEL COCAINE PHARMACOTHERAPIES: LAB STUDIES
    Margaret Haney; Fiscal Year: 2003
  9. Imaging inhibitory control in cocaine dependence
    CHIANG SHAN LI; Fiscal Year: 2006
  10. THC AND MARIJUANA--EFFECTS IN INDIVIDUALS WITH HIV/AIDS
    Margaret Haney; Fiscal Year: 2002

Detail Information

Publications275 found, 100 shown here

  1. ncbi Evidence for addiction-like behavior in the rat
    Véronique Deroche-Gamonet
    INSERM U588, Laboratoire de Physiopathologie des Comportements, Bordeaux Institute for Neurosciences, University Victor Segalen Bordeaux 2, Domaine de Carreire, rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    Science 305:1014-7. 2004
    ..These findings provide a new basis for developing a true understanding and treatment of addiction...
  2. ncbi Cocaine seeking habits depend upon dopamine-dependent serial connectivity linking the ventral with the dorsal striatum
    David Belin
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
    Neuron 57:432-41. 2008
    ....
  3. ncbi Cocaine cues and dopamine in dorsal striatum: mechanism of craving in cocaine addiction
    Nora D Volkow
    National Institute on Alcohol Abuse and Alcoholism, Bethesda Maryland 20892, USA
    J Neurosci 26:6583-8. 2006
    ..Because craving is a key contributor to relapse, strategies aimed at inhibiting dopamine increases from conditioned responses are likely to be therapeutically beneficial in cocaine addiction...
  4. ncbi Executive dysfunction in cocaine addiction: evidence for discordant frontal, cingulate, and cerebellar activity
    Robert Hester
    Department of Psychology and Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
    J Neurosci 24:11017-22. 2004
    ..The results reveal a neuroanatomical basis for this dysexecutive component to addiction, supporting the suggested importance cognitive functions may play in prolonging abuse or predisposing users toward relapse...
  5. ncbi Historical review: Molecular and cellular mechanisms of opiate and cocaine addiction
    Eric J Nestler
    Department of Psychiatry and Center for Basic Neuroscience The University of Texas Southwestern Medical Center 5323 Harry Hines Blvd, Dallas, TX 75390 9070, USA
    Trends Pharmacol Sci 25:210-8. 2004
    ..In this article, I present a historical review of basic research on opiate and cocaine addiction...
  6. ncbi Understanding polydrug use: review of heroin and cocaine co-use
    Francesco Leri
    Center for Studies in Behavioural Neurobiology, Concordia University, Montreal, Montreal, Canada
    Addiction 98:7-22. 2003
    ..Once clearly identified, pharmacological and neuroanatomical methods can be employed in self-administering laboratory animals to uncover the neurobiological correlates of specific patterns of co-use...
  7. ncbi Dopamine release in the dorsal striatum during cocaine-seeking behavior under the control of a drug-associated cue
    Rutsuko Ito
    Department of Experimental Psychology, University of Cambridge, Cambridge, CB2 3EB, United Kingdom
    J Neurosci 22:6247-53. 2002
    ..These data indicate a possible involvement of the dopaminergic innervation of the dorsal striatum in well established, or habitual, cocaine-seeking behavior...
  8. ncbi Stroke in young adults who abuse amphetamines or cocaine: a population-based study of hospitalized patients
    Arthur N Westover
    Department of Psychiatry, Division of Epidemiology and Preventive Medicine, The University of Texas Southwestern Medical Center at Dallas, TX 75390, USA
    Arch Gen Psychiatry 64:495-502. 2007
    ..The abuse of stimulant drugs is increasing in the western United States. Although numerous case reports and animal studies suggest a link with stroke, epidemiologic studies have yielded conflicting results...
  9. pmc Acute effects of cocaine on the neurobiology of cognitive control
    Hugh Garavan
    Institute of Neuroscience, School of Psychology, Trinity College Dublin, Dublin 2, Ireland
    Philos Trans R Soc Lond B Biol Sci 363:3267-76. 2008
    ..Furthermore, the effects of cocaine on midline function suggest a dopaminergically mediated intersection between cocaine's acute reinforcing effects and its effects on cognitive control...
  10. ncbi Escalation of cocaine self-administration does not depend on altered cocaine-induced nucleus accumbens dopamine levels
    Serge H Ahmed
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California, USA
    J Neurochem 86:102-13. 2003
    ..These findings show that changes in cocaine efficacy or pharmacokinetics do not play a critical role in cocaine intake escalation...
  11. ncbi Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5
    J A Bibb
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 410:376-80. 2001
    ..Our results suggest that changes in Cdk5 levels mediated by DeltaFosB, and resulting alterations in signalling involving D1 dopamine receptors, contribute to adaptive changes in the brain related to cocaine addiction...
  12. ncbi Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse
    David A Baker
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Nat Neurosci 6:743-9. 2003
    ..Thus, withdrawal from repeated cocaine increases susceptibility to relapse in part by reducing cystine/glutamate exchange, and restoring exchanger activity prevents cocaine-primed drug seeking...
  13. pmc A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependence
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, Box 8134, St Louis, Missouri 63110, USA
    Biol Psychiatry 64:922-9. 2008
    ..The goal of this study was to examine the association of this variant with cocaine dependence...
  14. ncbi Different requirements for cAMP response element binding protein in positive and negative reinforcing properties of drugs of abuse
    C L Walters
    Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 21:9438-44. 2001
    ..These data may provide the first paradigm for differential vulnerability to various drugs of abuse...
  15. pmc Lower level of endogenous dopamine in patients with cocaine dependence: findings from PET imaging of D(2)/D(3) receptors following acute dopamine depletion
    Diana Martinez
    Department of Psychiatry and Radiology, Columbia University College of Physicians and Surgeons, New York, USA
    Am J Psychiatry 166:1170-7. 2009
    ..The purpose of this study was to measure D(2)/D(3) receptors following acute dopamine depletion in cocaine-dependent volunteers relative to healthy comparison subjects...
  16. ncbi A single infusion of brain-derived neurotrophic factor into the ventral tegmental area induces long-lasting potentiation of cocaine seeking after withdrawal
    Lin Lu
    Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 24:1604-11. 2004
    ..These data suggest that BDNF-mediated neuroadaptations in mesolimbic areas are involved in the persistent cocaine seeking induced by exposure to drug cues after withdrawal...
  17. ncbi Glutamate transmission in the nucleus accumbens mediates relapse in cocaine addiction
    J L Cornish
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 20:RC89. 2000
    ..These data suggest an important role for nucleus accumbens glutamate and not dopamine transmission in cocaine-induced relapse to drug-seeking behavior...
  18. ncbi Reduced anterior corpus callosum white matter integrity is related to increased impulsivity and reduced discriminability in cocaine-dependent subjects: diffusion tensor imaging
    Frederick Gerard Moeller
    Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Neuropsychopharmacology 30:610-7. 2005
    ....
  19. ncbi Neurobiological evidence for hedonic allostasis associated with escalating cocaine use
    Serge H Ahmed
    Laboratoire de Neuropsychobiologie des Desadaptations, Universite de Bordeaux 2, CNRS UMR 5541, 146 rue Leo Saignat, Bordeaux 33076, France
    Nat Neurosci 5:625-6. 2002
    ....
  20. pmc Orbitofrontal cortex dysfunction in abstinent cocaine abusers performing a decision-making task
    K I Bolla
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Neuroimage 19:1085-94. 2003
    ..Compromised decision-making could contribute to the development of addiction and undermine attempts at abstinence...
  21. pmc Different neural substrates mediate cocaine seeking after abstinence versus extinction training: a critical role for the dorsolateral caudate-putamen
    Rita A Fuchs
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 26:3584-8. 2006
    ....
  22. ncbi Progression of changes in dopamine transporter binding site density as a result of cocaine self-administration in rhesus monkeys
    S R Letchworth
    Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA
    J Neurosci 21:2799-807. 2001
    ....
  23. ncbi Pattern of intake and drug craving predict the development of cocaine addiction-like behavior in rats
    David Belin
    CRI U862, Physiopathologie de l addiction, Institut Francois Magendie, Bordeaux Cedex 33077, France
    Biol Psychiatry 65:863-8. 2009
    ..We investigated whether the development of an addiction-like behavior in the rat is associated with the pattern of cocaine intake and with cocaine craving, a major feature of cocaine addiction...
  24. ncbi A consistent attentional bias for drug-related material in active cocaine users across word and picture versions of the emotional Stroop task
    Robert Hester
    Cognitive Neuroscience Laboratory, Department of Psychology, University of Melbourne, Parkville, Vic, Australia
    Drug Alcohol Depend 81:251-7. 2006
    ..These results provide corroborating evidence for cognitive biases being a hallmark of substance dependence...
  25. ncbi High dose cocaine use in São Paulo: a comparison of treatment and community samples
    C P Ferri
    National Addiction Centre, London, United Kingdom
    Subst Use Misuse 36:237-55. 2001
    ..Better methods are required to provide interventions to tackle the problems and risk behaviors of these cocaine users...
  26. ncbi Hypothalamic-pituitary-adrenal axis and sympatho-adreno-medullary responses during stress-induced and drug cue-induced cocaine craving states
    Rajita Sinha
    Department of Psychiatry, Yale University School of Medicine, S 112 Substance Abuse Center, Connecticut Mental Health Center, 34 Park Street, New Haven, CT 06519, USA
    Psychopharmacology (Berl) 170:62-72. 2003
    ..This study examined the response of brain stress circuits to environmental stimuli that are known to increase cocaine craving in cocaine dependent individuals...
  27. ncbi Genes associated with addiction: alcoholism, opiate, and cocaine addiction
    Mary Jeanne Kreek
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neuromolecular Med 5:85-108. 2004
    ..A few selected genetic variants that currently look promising for the study of alcohol, opiate, and cocaine addiction are discussed in this article...
  28. ncbi Cocaine dependence and d2 receptor availability in the functional subdivisions of the striatum: relationship with cocaine-seeking behavior
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Neuropsychopharmacology 29:1190-202. 2004
    ..Additional research is warranted to unravel potential neurobiological traits that might confer vulnerability to relapse in detoxified CCD subjects...
  29. ncbi Non-fatal cocaine overdose among injecting and non-injecting cocaine users in Sydney, Australia
    Sharlene Kaye
    National Drug and Alcohol Research Centre, University of New South Wales, Australia
    Addiction 99:1315-22. 2004
    ..To investigate the frequency of non-fatal cocaine overdose, and responses to overdoses, among injecting and non-injecting cocaine users...
  30. ncbi Cocaine use and the likelihood of nonfatal myocardial infarction and stroke: data from the Third National Health and Nutrition Examination Survey
    A I Qureshi
    Department of Neurosurgery and Toshiba Stroke Research Center, School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14209 1194, USA
    Circulation 103:502-6. 2001
    ..Increasing cocaine use in the US population, especially in younger individuals, mandates a more extensive investigation of this relationship...
  31. ncbi Striatal dopaminergic abnormalities in human cocaine users
    K Y Little
    Department of Psychiatry, University of Michigan, Ann Arbor VA Medical Center 48105, USA
    Am J Psychiatry 156:238-45. 1999
    ..Previous inconsistencies in results were perhaps related to selective radioligand affinity changes or a coexisting loss of dopamine neurons...
  32. ncbi Expectation enhances the regional brain metabolic and the reinforcing effects of stimulants in cocaine abusers
    Nora D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Neurosci 23:11461-8. 2003
    ..The enhanced cerebellar activation with expectation may reflect conditioned responses that are not linked to conscious responses...
  33. ncbi Effects of cocaine context on NAcc dopamine and behavioral activity after repeated intravenous cocaine administration
    C L Duvauchelle
    College of Pharmacy, Division of Pharmacology Toxicology, PHR 5 224, The University of Texas, Austin, TX, USA
    Brain Res 862:49-58. 2000
    ..The present study uniquely demonstrates concurrent context-dependent potentiation of behavioral and dopaminergic responses to cocaine occurring in conjunction with cocaine reward...
  34. pmc Prefrontal cortical dysfunction in abstinent cocaine abusers
    Karen Bolla
    Department of Neurology, Johns Hopkins University School of Medicine, 4940 Eastern Avenue, Baltimore, Maryland 21224, USA
    J Neuropsychiatry Clin Neurosci 16:456-64. 2004
    ..Since impairment in ECF may be a common feature of various neuropsychiatric disorders, these findings have applicability beyond the neurobiology of addiction...
  35. ncbi A BDNF infusion into the medial prefrontal cortex suppresses cocaine seeking in rats
    William J Berglind
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Eur J Neurosci 26:757-66. 2007
    ....
  36. ncbi Role of ERK in cocaine addiction
    Lin Lu
    Department of Neuropharmacology, National Institute on Drug Dependence, Peking University, Beijing 100083, China
    Trends Neurosci 29:695-703. 2006
    ..Pharmacological manipulations that decrease the extent to which cocaine and cocaine cues induce ERK activity might therefore be considered as potential treatments for cocaine addiction...
  37. pmc Cognitive control of drug craving inhibits brain reward regions in cocaine abusers
    Nora D Volkow
    National Institute on Drug Abuse, Bethesda, MD 20892, USA
    Neuroimage 49:2536-43. 2010
    ..This suggests that cocaine abusers may retain some ability to inhibit craving and that strengthening fronto-accumbal regulation may be therapeutically beneficial in addiction...
  38. ncbi Molecular neuroadaptations in the accumbens and ventral tegmental area during the first 90 days of forced abstinence from cocaine self-administration in rats
    Lin Lu
    Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse National Institutes of Health Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurochem 85:1604-13. 2003
    ..Cocaine self-administration produces long-lasting molecular neuroadaptations in the VTA and accumbens that may underlie cocaine relapse during periods of abstinence...
  39. ncbi Impact of self-administered cocaine and cocaine cues on extracellular dopamine in mesolimbic and sensorimotor striatum in rhesus monkeys
    C W Bradberry
    Departments of Psychiatry and Laboratory Medicine, Yale University School of Medicine and the West Haven Veteran s Administration Hospital, West Haven, Connecticut 06516, USA
    J Neurosci 20:3874-83. 2000
    ....
  40. ncbi Cognitive modeling analysis of decision-making processes in cocaine abusers
    Julie C Stout
    Department of Psychology, Indiana University, Bloomington, IN 47405 7007, USA
    Psychon Bull Rev 11:742-7. 2004
    ..The results of this analysis indicated, for the first time, that motivational and choice consistency factors, but not learning/memory were mainly responsible for the decision-making deficit of the cocaine abusers in this task...
  41. pmc Alpha 1-noradrenergic system role in increased motivation for cocaine intake in rats with prolonged access
    Sunmee Wee
    Committee on the Neurobiology of Addictive Disorders, SP30 2400, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Eur Neuropsychopharmacol 18:303-11. 2008
    ..The data suggest that activation of the alpha 1-noradrenergic system, perhaps in the BNST, is associated with increased motivation for cocaine in rats with extended access...
  42. ncbi A single in vivo exposure to cocaine abolishes endocannabinoid-mediated long-term depression in the nucleus accumbens
    Lawrence Fourgeaud
    Equipe Institut National de la Santé et de la Recherche Médicale Avenir Plasticité Synaptique Maturation et Addiction, Centre National de la Recherche Scientifique 5091, Institut Magendie des Neurosciences, 33077 Bordeaux Cedex, France
    J Neurosci 24:6939-45. 2004
    ..The results suggest that cocaine-induced loss of eCB retrograde signaling is caused by a reduction in the ability of mGluR5 to translate anterograde glutamate transmission into retrograde eCB signaling...
  43. pmc Neurocognitive deficits related to poor decision making in people behind bars
    Eldad Yechiam
    Technion Israel Institute of Technology, Haifa, Israel
    Psychon Bull Rev 15:44-51. 2008
    ..The present cognitive model provides a novel way for building a bridge between cognitive neuroscience and complex human behaviors...
  44. pmc Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex
    Rita Z Goldstein
    Medical Research, Brookhaven National Laboratory, Bldg 490, 30 Bell Avenue, Upton, NY 11973, USA
    Am J Psychiatry 159:1642-52. 2002
    ..Studies of the neurobiological processes underlying drug addiction primarily have focused on limbic subcortical structures. Here the authors evaluated the role of frontal cortical structures in drug addiction...
  45. ncbi Drug seeking becomes compulsive after prolonged cocaine self-administration
    Louk J M J Vanderschuren
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
    Science 305:1017-9. 2004
    ....
  46. ncbi Transition from moderate to excessive drug intake: change in hedonic set point
    S H Ahmed
    Division of Psychopharmacology, Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 282:298-300. 1998
    ..After 1 month of abstinence, escalation of cocaine intake was reinstated to a higher level than before. These findings may provide an animal model for studying the development of excessive drug intake and the basis of addiction...
  47. ncbi Human therapeutic cocaine vaccine: safety and immunogenicity
    Thomas R Kosten
    Department of Psychiatry, School of Medicine, Yale University, 950 Campbell Avenue, West Haven, CT 06516, USA
    Vaccine 20:1196-204. 2002
    ..Thus, the therapeutic vaccine was well tolerated with dose related increases in antibody levels, and a high proportion of patients recruited into the study were retained...
  48. ncbi Diffusion tensor imaging eigenvalues: preliminary evidence for altered myelin in cocaine dependence
    F Gerard Moeller
    Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center Houston, 1300 Moursund, Houston, TX 77030, USA
    Psychiatry Res 154:253-8. 2007
    ....
  49. ncbi Efficacy of central nervous system stimulant treatment for cocaine dependence: a systematic review and meta-analysis of randomized controlled clinical trials
    Xavier Castells
    Psychiatry Service, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Catalonia, Spain
    Addiction 102:1871-87. 2007
    ..To evaluate the efficacy of central nervous system (CNS) stimulants compared with placebo for the treatment of cocaine dependence...
  50. pmc High impulsivity predicts the switch to compulsive cocaine-taking
    David Belin
    Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Science 320:1352-5. 2008
    ..This study shows experimental evidence that a shift from impulsivity to compulsivity occurs during the development of addictive behavior, which provides insights into the genesis and neural mechanisms of drug addiction...
  51. ncbi Incubation of cocaine craving after withdrawal: a review of preclinical data
    Lin Lu
    Behavioral Neuroscience Branch, IRP NIDA NIH DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuropharmacology 47:214-26. 2004
    ..4. Incubation of cocaine craving after withdrawal is associated with increases in the levels of brain-derived neurotrophic factor (BDNF) in mesolimbic dopamine areas...
  52. pmc Limbic activation during cue-induced cocaine craving
    A R Childress
    Addiction Treatment Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Am J Psychiatry 156:11-8. 1999
    ..Since signals for cocaine induce limbic brain activation in animals and cocaine craving in humans, the objective of this study was to test whether limbic activation occurs during cue-induced craving in humans...
  53. pmc Liking and wanting of drug and non-drug rewards in active cocaine users: the STRAP-R questionnaire
    R Z Goldstein
    Department of Medical Research, Center for Translational Neuroimaging, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    J Psychopharmacol 24:257-66. 2010
    ..Additional studies are required to assess the reliability of the STRAP-R in larger samples and to examine its validity in measuring the subjective value attributed to experienced reinforcers or in predicting behaviour...
  54. ncbi Ambient temperature and mortality from unintentional cocaine overdose
    P M Marzuk
    Department of Psychiatry, Cornell University Medical College, New York, NY 10021, USA
    JAMA 279:1795-800. 1998
    ..Hot weather taxes cardiovascular function and is associated with increased deaths from heart disease. Cocaine can cause hypertension, tachycardia, coronary vasospasm, arrhythmias, and increased core temperature...
  55. ncbi Crack-heroin speedball injection and its implications for vein care: qualitative study
    Tim Rhodes
    Centre for Research on Drugs and Health Behaviour, London School of Hygiene and Tropical Medicine, London, UK
    Addiction 102:1782-90. 2007
    ..We report on an exploratory qualitative study investigating drug injectors' narratives of vein damage and groin (femoral vein) injection associated with the injection of crack-heroin speedball...
  56. pmc PET imaging of the effects of age and cocaine on the norepinephrine transporter in the human brain using (S,S)-[(11)C]O-methylreboxetine and HRRT
    Yu Shin Ding
    Yale PET Center, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520 8048, USA
    Synapse 64:30-8. 2010
    ....
  57. ncbi Neurobiology of relapse to heroin and cocaine seeking: a review
    Uri Shalev
    Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    Pharmacol Rev 54:1-42. 2002
    ..The data reviewed also suggest that the neuronal events mediating drug-induced reinstatement are to some degree dissociable from those mediating drug reinforcement...
  58. ncbi Central amygdala ERK signaling pathway is critical to incubation of cocaine craving
    Lin Lu
    Behavioral Neuroscience Branch, Intramural Research Program National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    Nat Neurosci 8:212-9. 2005
    ..Results suggest that the incubation of cocaine craving is mediated by time-dependent increases in the responsiveness of the central amygdala ERK pathway to cocaine cues...
  59. ncbi Route of cocaine administration: patterns of use and problems among a Brazilian sample
    C P Ferri
    National Addiction Centre, London, UK
    Addict Behav 24:815-21. 1999
    ..These problems, compounded by the larger doses being used and their greater involvement in prostitution, place crack cocaine users at higher risk from HIV infection and other sexually transmitted diseases as well as other physical risks...
  60. ncbi Transitions in the route of cocaine administration--characteristics, direction and associated variables
    J Dunn
    Departamento de Psiquiatria, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Brazil
    Addiction 94:813-24. 1999
    ..To examine transitions in the route of administration of cocaine and the variables associated with them...
  61. ncbi Subsecond dopamine release promotes cocaine seeking
    Paul E M Phillips
    Department of Psychology, Neuroscience Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Nature 422:614-8. 2003
    ..These findings reveal an unprecedented role for dopamine in the regulation of drug taking in real time...
  62. ncbi Impaired inhibitory control of behavior in chronic cocaine users
    Mark T Fillmore
    Department of Psychology, University of Kentucky, Lexington 40506 0044, USA
    Drug Alcohol Depend 66:265-73. 2002
    ..These findings are important because they identify a specific deficit involving behavioral inhibition that could contribute to cocaine abuse, and explain its association with other disorders of self-regulation, such as ADHD...
  63. pmc Anterior cingulate cortex hypoactivations to an emotionally salient task in cocaine addiction
    Rita Z Goldstein
    Department of Medical Research, Center for Translational Neuroimaging, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Proc Natl Acad Sci U S A 106:9453-8. 2009
    ..Interventions to strengthen ACC reactivity or interconnectivity may be beneficial in enhancing top-down monitoring and emotion regulation as a strategy to reduce impulsive and compulsive behavior in addiction...
  64. ncbi Activation of orbital and medial prefrontal cortex by methylphenidate in cocaine-addicted subjects but not in controls: relevance to addiction
    Nora D Volkow
    National Institute of Drug Abuse, Rockville, Maryland 20857, USA
    J Neurosci 25:3932-9. 2005
    ..It also suggests that the mesothalamic DA pathway may contribute to these processes...
  65. ncbi Cocaine dependence and acute cocaine induce decreases of monocyte proinflammatory cytokine expression across the diurnal period: autonomic mechanisms
    Michael R Irwin
    Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, CA 90095 7057, USA
    J Pharmacol Exp Ther 320:507-15. 2007
    ..Targeting sympathovagal balance might represent a novel strategy for partial amelioration of impairments of innate immunity in cocaine dependence...
  66. ncbi Acute cortisol administration triggers craving in individuals with cocaine dependence
    Igor Elman
    Behavioral Psychopharmacology Research Laboratory, Harvard Medical School McLean Hospital, Belmont, MA 02478, USA
    Psychopharmacol Bull 37:84-9. 2003
    ..These pilot data suggest that cortisol can induce a state that is associated with drug abuse...
  67. ncbi Cocaine use in New South Wales, Australia, 1996-2000: 5 year monitoring of trends in price, purity, availability and use from the illicit drug reporting system
    Shane Darke
    National Drug and Alcohol Research Centre, University of New South Wales, Sydney NSW 2052, Australia
    Drug Alcohol Depend 67:81-8. 2002
    ..The regular and formal monitoring of illicit drug trends enabled substantial changes in the cocaine market in Sydney to be detected, and the information to be fed back to the health and law enforcement sectors...
  68. ncbi Relationship between extent of cocaine use and dependence among adolescents and adults in the United States
    Kevin Chen
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, Unit 20, New York, NY 10032, USA
    Drug Alcohol Depend 68:65-85. 2002
    ..Implications of the findings for the epidemiological study of cocaine use and dependence are discussed...
  69. ncbi Dynamic BDNF activity in nucleus accumbens with cocaine use increases self-administration and relapse
    Danielle L Graham
    Department of Psychiatry, The Seay Center for Basic and Applied Research in Psychiatric Illness, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    Nat Neurosci 10:1029-37. 2007
    ..These findings suggest that dynamic induction and release of BDNF from NAc neurons during cocaine use promotes the development and persistence of addictive behavior...
  70. ncbi Clock reset for alcoholism
    Vadim Yuferov
    Nat Med 11:23-4. 2005
  71. pmc Transcriptional profiling in the human prefrontal cortex: evidence for two activational states associated with cocaine abuse
    E Lehrmann
    Cellular Neurobiology Research Branch, National Institute on Drug Abuse, NIH, DHHS, Baltimore, MD 21224, USA
    Pharmacogenomics J 3:27-40. 2003
    ..These data suggest that cocaine abuse targets a distinct subset of genes in the dlPFC, resulting in either a state of acute activation in which increased gene expression predominates, or a relatively destimulated, refractory phase...
  72. ncbi Downregulation of kappa-opioid receptors in basolateral amygdala and septum of rats withdrawn for 14 days from an escalating dose "binge" cocaine administration paradigm
    Alexis Bailey
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York 10021, USA
    Synapse 61:820-6. 2007
    ..The observed lowering in KOP-r binding, which was shown in two brain regions of cocaine withdrawn animals, might contribute to the persistent dysphoria reported a long time after the discontinuation of the drug...
  73. ncbi Epidemiological estimates of risk in the process of becoming dependent upon cocaine: cocaine hydrochloride powder versus crack cocaine
    Chuan Yu Chen
    Bloomberg School of Public Health, Johns Hopkins University, 624 N Broadway, 8th Floor, Baltimore, MD 21205, USA
    Psychopharmacology (Berl) 172:78-86. 2004
    ..To estimate the risk of experiencing clinical features of cocaine dependence within 1-2 years of starting cocaine use, and to examine whether crack smoking might increase this risk...
  74. pmc Cocaine-predictive stimulus induces drug-seeking behavior and neural activation in limbic brain regions after multiple months of abstinence: reversal by D(1) antagonists
    R Ciccocioppo
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 98:1976-81. 2001
    ..Moreover, the results implicate D(1)-dependent neural mechanisms within the medial prefrontal cortex and basolateral amygdala as substrates for cocaine-seeking behavior elicited by cocaine-predictive environmental stimuli...
  75. ncbi Cocaine use in Europe - a multi-centre study: patterns of use in different groups
    Michael Prinzleve
    Zentrum für Interdisziplinäre Suchtforschung der Universität Hamburg, Germany
    Eur Addict Res 10:147-55. 2004
    ..The study investigates patterns of cocaine powder and crack cocaine use of different groups in nine European cities...
  76. ncbi Role of dopamine D2-like receptors in cocaine self-administration: studies with D2 receptor mutant mice and novel D2 receptor antagonists
    S Barak Caine
    Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    J Neurosci 22:2977-88. 2002
    ..Our results also suggest that D3 and D4 receptors do not play major roles in the modulation of cocaine self-administration by D2-like drugs...
  77. pmc Role of the anterior cingulate and medial orbitofrontal cortex in processing drug cues in cocaine addiction
    R Z Goldstein
    Brookhaven National Laboratory, P O Box 5000, Upton, NY 11973 5000, USA
    Neuroscience 144:1153-9. 2007
    ....
  78. pmc Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving
    KELLY L CONRAD
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, Illinois 60064, USA
    Nature 454:118-21. 2008
    ....
  79. ncbi Cocaine dependence: a disease of the brain's reward centers
    C A Dackis
    Treatment Research Center, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    J Subst Abuse Treat 21:111-7. 2001
    ..Treatment principles, including engagement, motivational enhancement, abstinence strategies, and craving reduction are discussed in terms of biological rationales...
  80. pmc The role of acetylcholine in cocaine addiction
    Mark J Williams
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 8564, USA
    Neuropsychopharmacology 33:1779-97. 2008
    ....
  81. ncbi Cocaine use in Europe - a multi-centre study. Methodology and prevalence estimates
    Christian Haasen
    Zentrum für Interdisziplinäre Suchtforschung, Klinik für Psychiatrie and Psychotherapie, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Eur Addict Res 10:139-46. 2004
    ..Specific strategies need to be developed to address problematic cocaine use in these subgroups...
  82. pmc Gene expression profile of the nucleus accumbens of human cocaine abusers: evidence for dysregulation of myelin
    Dawn N Albertson
    Departments of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Neurochem 88:1211-9. 2004
    ..These findings suggest a dysregulation of myelin in human cocaine abusers...
  83. ncbi Disulfiram treatment for cocaine dependence in methadone-maintained opioid addicts
    I L Petrakis
    Department of Psychiatry, Yale University, New Haven, Connecticut, USA
    Addiction 95:219-28. 2000
    ..We evaluated the efficacy of disulfiram for cocaine dependence, both with and without co-morbid alcohol abuse, in a group of methadone-maintained opioid addicts...
  84. pmc Toward a model of drug relapse: an assessment of the validity of the reinstatement procedure
    David H Epstein
    Clinical Pharmacology and Therapeutics Research Branch, IRP NIDA NIH DHHS, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 189:1-16. 2006
    ..The reinstatement model is widely used to study relapse to drug addiction. However, the model's validity is open to question...
  85. ncbi Renewal of drug seeking by contextual cues after prolonged extinction in rats
    Hans S Crombag
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland 21224, USA
    Behav Neurosci 116:169-73. 2002
    ..The authors suggest that the renewal procedure can be used to study mechanisms underlying relapse to drug seeking elicited by drug-associated contextual stimuli...
  86. ncbi Addiction as a computational process gone awry
    A David Redish
    Department of Neuroscience, 6 145 Jackson Hall, 321 Church Street SE, University of Minnesota, Minneapolis, MN 55455, USA
    Science 306:1944-7. 2004
    ..The model provides an explanation for important aspects of the addiction literature and provides a theoretic view-point with which to address other aspects...
  87. ncbi The National Treatment Outcome Research Study (NTORS): 4-5 year follow-up results
    Michael Gossop
    National Addiction Centre, The Maudsley Institute of Psychiatry, London, UK
    Addiction 98:291-303. 2003
    ..NTORS investigates outcomes for drug misusers treated in existing services in residential and community settings...
  88. ncbi The role of endocannabinoid transmission in cocaine addiction
    Jonathon C Arnold
    Department of Pharmacology, University of Sydney, NSW 2006, Australia
    Pharmacol Biochem Behav 81:396-406. 2005
    ..This review highlights research indicating that the endocannabinoid system may subserve certain aspects of cocaine addiction and suggests avenues for future investigation...
  89. ncbi The role of dorsal vs ventral striatal pathways in cocaine-seeking behavior after prolonged abstinence in rats
    R E See
    Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    Psychopharmacology (Berl) 194:321-31. 2007
    ..Recent studies have implicated an important role for the dorsal striatum during craving for cocaine and in cocaine-seeking after abstinence in rats...
  90. ncbi Human immunodeficiency virus prevention and the potential of drug abuse treatment
    David S Metzger
    University of Pennsylvania Veteran s Affairs Medical Center, Center for Studies of Addiction, Philadelphia, Pennsylvania 19104, USA
    Clin Infect Dis 37:S451-6. 2003
    ....
  91. pmc Motivational responses to natural and drug rewards in rats with neonatal ventral hippocampal lesions: an animal model of dual diagnosis schizophrenia
    R Andrew Chambers
    Division of Molecular Psychiatry, West Haven Veterans Administration Hospital, USA
    Neuropsychopharmacology 27:889-905. 2002
    ....
  92. pmc The effect of practice on a sustained attention task in cocaine abusers
    Rita Z Goldstein
    Department of Medical Research, Center for Translational Neuroimaging, Brookhaven National Laboratory, P O Box 5000, Upton, NY 11973 5000, USA
    Neuroimage 35:194-206. 2007
    ....
  93. pmc Is there epidemiological evidence to support the idea that a cocaine dependence syndrome emerges soon after onset of cocaine use?
    Beth A Reboussin
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Neuropsychopharmacology 31:2055-64. 2006
    ....
  94. pmc Neuroplasticity in the mesolimbic dopamine system and cocaine addiction
    M J Thomas
    Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA
    Br J Pharmacol 154:327-42. 2008
    ..Finally, we speculate on how these factors may interact to initiate and sustain cocaine psychomotor sensitization and cocaine seeking...
  95. ncbi Differential effects of dopaminergic agents on locomotor sensitisation and on the reinstatement of cocaine-seeking and food-seeking behaviour
    C Dias
    Laboratoire de Neuropsychobiologie des Desadaptations, UMR CRNS 5541, Universite Victor Segalen, Bordeaux 2, 146, rue Leo Saignat, BP 31, 33076 Bordeaux Cedex, France
    Psychopharmacology (Berl) 175:414-27. 2004
    ..The dopaminergic pathways are involved in natural and drug reward related processes...
  96. ncbi Ionotropic and metabotropic glutamate receptor antagonism attenuates cue-induced cocaine seeking
    Pia Bäckström
    Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
    Neuropsychopharmacology 31:778-86. 2006
    ..Accordingly, drugs with antagonist properties at various glutamate receptor subtypes could be useful in prevention of relapse induced by conditioned stimuli...
  97. pmc Continuous intracerebroventricular infusion of the competitive NMDA receptor antagonist, LY235959, facilitates escalation of cocaine self-administration and increases break point for cocaine in Sprague-Dawley rats
    Richard M Allen
    Department of Psychology, University of Colorado at Denver and Health Sciences Center, Downtown Denver Campus, CO 80217, United States
    Pharmacol Biochem Behav 88:82-8. 2007
    ....
  98. ncbi Effects of dopamine receptor antagonists (D1 and D2) on the demand for smoked cocaine base in rhesus monkeys
    U C Campbell
    Department of Psychiatry, University of Minnesota Medical School, Minneapolis 55455 0392, USA
    Psychopharmacology (Berl) 144:381-8. 1999
    ..Previous studies suggest that dopamine antagonists may reduce the reinforcing effects of cocaine. However, the effects of these antagonists on the demand for smoked cocaine base have not been quantified...
  99. ncbi Treatment of cocaine dependence and depression
    Bruce J Rounsaville
    Department of Psychiatry, Yale University School of Medicine, New Haven, and Veterans Affairs Connecticut Healthcare, West Haven, Connecticut 06516, USA
    Biol Psychiatry 56:803-9. 2004
    ....
  100. ncbi Modafinil and cocaine: a double-blind, placebo-controlled drug interaction study
    Charles A Dackis
    Department of Psychiatry, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Drug Alcohol Depend 70:29-37. 2003
    ..Furthermore, pretreatment with modafinil did not intensify cocaine euphoria or cocaine-induced craving. In fact, cocaine euphoria was significantly blunted (P=0.02) in one of our subjective measures...
  101. ncbi Extinction-induced upregulation in AMPA receptors reduces cocaine-seeking behaviour
    Michael A Sutton
    Division of Molecular Psychiatry and the Interdepartmental Neuroscience Program, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 421:70-5. 2003
    ....

Research Grants72

  1. Behavioral correlates of fMRI response in cocaine users
    Rita Goldstein; Fiscal Year: 2006
    ..abstract_text> ..
  2. TREATMENT FOR DUALLY DEPENDENT METHADONE PATIENTS
    Nancy Petry; Fiscal Year: 2002
    ....
  3. Topiramate for alcohol and cocaine dependence
    Kyle Kampman; Fiscal Year: 2008
    ..abstract_text> ..
  4. Cocaine Withdrawal and Pharmacotherapy Response
    Mehmet Sofuoglu; Fiscal Year: 2010
    ..This proposal, by testing the efficacy of carvedilol and investigating the influence of withdrawal severity on carvedilol's efficacy, may result in development of more effective treatments for cocaine addiction. ..
  5. Progestrone and the Effects of Nicotine
    Mehmet Sofuoglu; Fiscal Year: 2006
    ..By characterizing the progesterone effects on nicotine dependence, this study may provide a better understanding of the mechanisms which mediate the sex and menstrual cycle phase effects on nicotine dependence. ..
  6. GABA Medications for Tobacco Addiction
    Mehmet Sofuoglu; Fiscal Year: 2009
    ..The findings of this study will provide valuable information to develop new pharmacotherapies for smoking cessation. ..
  7. Medication Development for Marijuana Relapse
    Margaret Haney; Fiscal Year: 2008
    ..abstract_text> ..
  8. NOVEL COCAINE PHARMACOTHERAPIES: LAB STUDIES
    Margaret Haney; Fiscal Year: 2003
    ....
  9. Imaging inhibitory control in cocaine dependence
    CHIANG SHAN LI; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  10. THC AND MARIJUANA--EFFECTS IN INDIVIDUALS WITH HIV/AIDS
    Margaret Haney; Fiscal Year: 2002
    ....
  11. Pharmacotherapy for opioid and cocaine dependence
    Bruce Rounsaville; Fiscal Year: 2005
    ..4. To examine depression as a predictor of response. 5. To examine three month follow-up status after completing the treatment trial for continuation in treatment, abstinence from illicit drugs, and depressive symptoms. ..
  12. Scientific Meeting of ISRI
    FREDERICK MOELLER; Fiscal Year: 2005
    ..Through all sessions, the planning committee will strive for a balance of attendance and participation from junior investigators, women, trainees, and underrepresented populations through travel awards for these groups. ..
  13. SEROTONIN, IMPULSIVITY AND COCAINE DEPENDENCE TREATMENT
    FREDERICK MOELLER; Fiscal Year: 2004
    ..Aim 3. To measure impulsivity in subjects undergoing treatment for cocaine dependence using laboratory tasks to determine if changes in impulsivity predict response to treatment for cocaine dependence. ..
  14. Combined Treatment for Cocaine-Alcohol Dependence
    Joy Schmitz; Fiscal Year: 2005
    ..abstract_text> ..
  15. BEH PHARM TREATMENTS FOR ALCOHOL/NICOTINE DEPENDENCE
    Joy Schmitz; Fiscal Year: 2001
    ..Finally, the proposed study will continue and extend the scope of our ongoing research program designed to evaluate the joint effects of behavioral and pharmacological interventions for substance dependence. ..
  16. Serotonin, Drug Use and MDMA Induced Deficits
    FREDERICK MOELLER; Fiscal Year: 2005
    ..Specific Aim 3: To determine whether neurobehavioral deficits seen in heavy MDMA users are related to serotonergic function as measured by a mCPP neuroendocrine challenge in these subjects. ..
  17. PREVENTION OF SMOKING RELAPSE IN WOMEN
    Joy Schmitz; Fiscal Year: 2001
    ....
  18. INTEGRATED TREATMENT FOR COCAINE AND MOOD DISORDERS
    Joy Schmitz; Fiscal Year: 2003
    ....
  19. Contingency Management plus Levodopa/Carbidopa for Trtment. of Cocaine Dependence
    JOY MARIE SCHMITZ; Fiscal Year: 2010
    ..In conclusion, this study will validate the usefulness of a novel behavioral-pharmacological treatment and shed light on the mechanisms underlying the synergism between DA augmentation strategies and reinforcement-based therapies. ..
  20. A Long-term Follow-up Study of Drug-Dependent Mothers and Children
    Yih Ing Hser; Fiscal Year: 2010
    ..The study will also lay the foundation for future in-depth investigation of the children of these mothers with histories of substance abuse. ..
  21. Effectiveness of extended treatments for drug dependence
    James R McKay; Fiscal Year: 2010
    ..Other analyses will test mediation hypotheses, examine potential moderator effects, and test the impact of disease management on HIV risk behaviors. ..
  22. Effectiveness and Costs of Enhanced Cocaine Treatments
    James McKay; Fiscal Year: 2005
    ..voucher reinforcement. Additional analyses will identify predictors of response to the TAU+V and TAU+S conditions, and test predictions regarding possible mechanisms of action. ..
  23. Naltrexone for Bipolar Disorder and Alcohol Dependence
    E Sherwood Brown; Fiscal Year: 2006
    ..Alcohol use is the primary outcome, and alcohol craving is the secondary outcome. Manic and depressive symptom severity and the relationship between changes in alcohol use and changes in mood will be expIored. ..
  24. Sex-Specific Pathways Linking Stress and Drug Abuse
    Rajita Sinha; Fiscal Year: 2008
    ..Such an understanding will have important implications for the development of gender-specific treatments for cocaine dependence that will ultimately improve the health of cocaine-addicted women and their families. ..
  25. Treatment System Impact & Outcomes of Proposition 36
    Yih Ing Hser; Fiscal Year: 2006
    ..The project will produce recommendations to improve treatment strategies and inform future policy and practice at the national, state, and local levels. ..
  26. Reducing HIV/AIDS and Drug Abuse: Linking Compulsory Rehabilitation to Methadone
    Yih Ing Hser; Fiscal Year: 2008
    ..If proven effective, the program can be widely applied in China and in other parts of the world to reduce heroin use and related HIV risk behaviors. [unreadable] [unreadable] [unreadable]..
  27. Lofexidine to Prevent Stress-Related Opiate Relapse
    Rajita Sinha; Fiscal Year: 2007
    ..abstract_text> ..
  28. Effectiveness of Extended Telephone Monitoring
    James McKay; Fiscal Year: 2007
    ..Economic analyses will determine the cost-effectiveness and benefit-cost of TMC and TMF relative to TAU, andto ach other. ..
  29. AFTERCARE FOR SUBSTANCE ABUSERS
    James McKay; Fiscal Year: 2008
    ..The cost-effectiveness and benefit cost of each of the enhanced interventions will also be determined, through a collaboration with Dr. Michael French. [unreadable] [unreadable] [unreadable] [unreadable]..
  30. DRUG ABUSE: EPIDEMIOLOGY, TREATMENT PROCESS, & OUTCOMES
    Yih Ing Hser; Fiscal Year: 2003
    ..The applicant also expects to grow professionally as Associate Director of the UCLA Drug Abuse Research Center. ..
  31. Treating Asthma Patients with Major Depressive Disorder
    E Sherwood Brown; Fiscal Year: 2004
    ....
  32. Cholesterol and fatty acids in cocaine addiction relapse
    Laure Buydens Branchey; Fiscal Year: 2004
    ..If our preliminary findings are confirmed, the use of fatty acids supplements or changes in dietary habits could have a significant potential in the prevention of relapse in a subgroup of cocaine addicts. ..
  33. EFFECTS OF BUSPIRONE IN WITHDRAWAL FROM OPIATES
    Laure Buydens Branchey; Fiscal Year: 2002
    ..Buspirone has additional advantages. It is not sedating, has no withdrawal symptoms, has no abuse potential, does not potentiate central nervous system depressants and does not induce psychomotor impairment. ..
  34. HIPPOCAMPAL FUNCTION DURING CORTICOSTEROID THERAPY
    E Sherwood Brown; Fiscal Year: 2004
    ..Through this award, the Pl will extend his previous research experience by adding new skills and knowledge which will be used for investigations at the interface of neuroscience and clinical research. ..
  35. A 12 YEAR FOLLOW UP OF A COCAINE DEPENDENT SAMPLE
    Yih Ing Hser; Fiscal Year: 2003
    ..abstract_text> ..
  36. Readiness for Implementation of Research to Practice
    Yih Ing Hser; Fiscal Year: 2004
    ..abstract_text> ..
  37. AFTERCARE FOR COCAINE PATIENTS--EFFECTIVENESS AND COSTS
    James McKay; Fiscal Year: 2001
    ..However, it is expected that MIN aftercare will be cost-effective for low problem severity ("good prognosis") patients, whereas IND aftercare will be cost-effective for high problem severity ("poor prognosis") patients. ..
  38. THERAPEUTIC WORKPLACE TO PREVENT HIV TRANSMISSION
    Kenneth Silverman; Fiscal Year: 2003
    ..abstract_text> ..
  39. HIV AND COCAINE USE--CARDIOVASCULAR EFFECTS AND THERAPY
    Arthur Margolin; Fiscal Year: 2003
    ..abstract_text> ..
  40. REGULATION OF MESOLIMBIC DOPAMINE BY ENDOGENOUS COMPOUND
    Peter Kalivas; Fiscal Year: 2003
    ..Furthermore, the anatomical and functional mapping of the motive circuit will provide a basis for interpreting future imaging studies in humans where attempts are made to correlate changes in spatially discrete nuclei. ..
  41. ENVIRONMENTAL INFLUENCES ON COCAINE SELF-ADMINISTRATION
    NICHOLAS GOEDERS; Fiscal Year: 2007
    ..The experiments described in this revised application were designed with these stipulations in mind, taking into consideration the recommendations of the reviewers of the previous submission. ..
  42. DETERMINANTS OF DRUG EFFECTS ON DRUG MAINTAINED BEHAVIOR
    NICHOLAS GOEDERS; Fiscal Year: 2001
    ..abstract_text> ..
  43. Women and Smoking: Understanding Socioeconomic Influences
    Stephen Higgins; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  44. TREATING COCAINE ABUSE: A BEHAVIORAL APPROACH
    Stephen Higgins; Fiscal Year: 2007
    ..abstract_text> ..
  45. Employment-Based Addiction Pharmacotherapy
    Kenneth Silverman; Fiscal Year: 2009
    ..abstract_text> ..
  46. CBT and Modafinil for Cocaine Addiction
    Robert Malcolm; Fiscal Year: 2009
    ....
  47. INCREASING ALCOHOLICS MOTIVATION TO QUIT SMOKING
    Damaris Rohsenow; Fiscal Year: 2001
    ..The effects of the intervention will be examined on number of smoking quit attempts, reductions in nicotine dose delivery, smoking treatment attended, alcohol and drug use, etc., during the next 12 months. ..
  48. Neurochemistry of Cocaine Reinforcement
    NICHOLAS GOEDERS; Fiscal Year: 2002
    ..These results will also provide evidence of the role that is played by steroid hormones in shaping the functional activity of the brain. ..
  49. Voucher-based incentives to treat pregnant smokers
    Stephen T Higgins; Fiscal Year: 2010
    ..Overall, the proposed studies have the potential to contribute important new information on effective treatments for one of our nation's most daunting drug abuse problems. ..
  50. Combined Voltammetry/Electrophysiology in Behaving Rats
    REGINA CARELLI; Fiscal Year: 2002
    ..As such, we will be able to directly examine the contribution of DA in mediating underlying cellular mechanisms in the Acb that are involved in encoding information related to cocaine reinforcement. ..
  51. Future Directions in Contingency Management Research
    Stephen Higgins; Fiscal Year: 2004
    ..g., cognitive behavior therapy). Critical discussion of these issues is important to the future of CM and to the research agenda of NIDA. ..
  52. Brain dopamine alterations in human cocaine users
    KARLEY LITTLE; Fiscal Year: 2006
    ..Goal #4 is to confirm these increases and determine if induction of related genes occurs in human cocaine users. Specific Aim # 4 is to test the hypotheses that COX-1, NHE-1 and related mRNA's are increased in dopamine neurons. ..
  53. A THERAPEUTIC WORKPLACE FOR HOMELESS ALCOHOLICS
    Kenneth Silverman; Fiscal Year: 2004
    ..abstract_text> ..
  54. Spirituality Guided HIV Prevention For Drug Users
    Arthur Margolin; Fiscal Year: 2004
    ..abstract_text> ..
  55. ACUPUNCTURE AND COPING SKILLS TRAINING FOR COCAINE ABUSE
    Arthur Margolin; Fiscal Year: 2004
    ..Both clinical efficacy, cost, as well as treatment/patient matching variables, will be examined. ..
  56. Crack & Health Service Use--A Natural History Approach
    Russel Falck; Fiscal Year: 2005
    ....
  57. Spiritual Self-Reevaluation Therapy for HIV+ Drug Users
    Arthur Margolin; Fiscal Year: 2005
    ..Treatment process variables to be assessed include HIV information, motivation, and behavioral skills and the shift in addict and spiritual self-schemas from pre to post-treatment. ..
  58. MOTIVATING SUBSTANCE ABUSERS TO QUIT SMOKING
    Damaris Rohsenow; Fiscal Year: 2005
    ..The study will provide significant information about methods of reducing smoking among substance abusers. ..
  59. Ondansetron and Naltrexone:Cue Reactivity and Drinking
    Damaris Rohsenow; Fiscal Year: 2007
    ..Evidence will also be provided about subpopulations more likely to benefit from each medications. ..
  60. STRESS AND THE NEUROBIOLOGY OF DRUG AND ALCOHOL DEPENDE
    NICHOLAS GOEDERS; Fiscal Year: 2004
    ..The primary goal of this Training Program is to provide students and young scientists with comprehensive guidance in stress and drug abuse research. ..
  61. A REINFORCEMENT-BASED THERAPEUTIC WORKPLACE
    Kenneth Silverman; Fiscal Year: 2006
    ..This research could provide firm scientific foundation for the dissemination of Therapeutic Workplace businesses in the long-term treatment of cocaine addiction and unemployment. ..
  62. Lower-Cost Contingency Management in a Group Setting
    Nancy Petry; Fiscal Year: 2005
    ..abstract_text> ..
  63. Training Therapists to Administer Contingency Management
    Nancy Petry; Fiscal Year: 2007
    ..Both short-term and long-term efficacy, as well as cost-effectiveness, will be evaluated when CM is administered by community-based therapists. ..
  64. Treatment Utilization for Alcohol-Related Problems
    Li Tzy Wu; Fiscal Year: 2002
    ....
  65. Cognitive-Behavioral Treatments/Pathological Gambling
    Nancy Petry; Fiscal Year: 2008
    ..Patient characteristics that may be associated with outcomes will be evaluated, and a cost-effectiveness evaluation of the interventions also will be conducted. [unreadable] [unreadable]..
  66. Inhalant Use/Dependence: Incidence and Comorbidity
    Li Tzy Wu; Fiscal Year: 2005
    ..Gaps in our knowledge of the natural course of inhalant use will be specified for future research. ..
  67. Epdemiology of Non-Medical Prescription Anagesic Use
    Li Tzy Wu; Fiscal Year: 2009
    ..Such findings will be vital to policy makers in predicting the potential burden of NMPAU-related problems. ..
  68. PET IMAGING AND COCAINE NEUROPHARMACOLOGY IN MONKEYS
    Leonard Howell; Fiscal Year: 2006
    ..The results obtained will also evaluate the effectiveness of monoamine transporters as potential targets for cocaine medications development. ..
  69. Glutamate Signaling and Drug Abuse
    MOHAMMADHOSSEIN GHASEMZADEH; Fiscal Year: 2007
    ....
  70. Role of norepinephrine and the amygdala in drug relapse
    MATTHEW FELTENSTEIN; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  71. Transitional States in Drug Addiction
    Leonard Howell; Fiscal Year: 2007
    ..These integrated efforts, including behavioral and mechanistic approaches, will provide a comprehensive analysis to elucidate transitional states in cocaine addiction. [unreadable] [unreadable]..