alcoholism

Summary

Summary: A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)

Top Publications

  1. ncbi Alcohol and public health
    Robin Room
    Centre for Social Research on Alcohol and Drugs, Stockholm University, Stockholm, Sweden
    Lancet 365:519-30. 2005
  2. ncbi Alcohol use and sexual risks for HIV/AIDS in sub-Saharan Africa: systematic review of empirical findings
    Seth C Kalichman
    Department of Psychology, University of Connecticut, 406 Babbidge Road, Storrs, CT 06269, USA
    Prev Sci 8:141-51. 2007
  3. ncbi Brief interventions for alcohol problems: a meta-analytic review of controlled investigations in treatment-seeking and non-treatment-seeking populations
    Anne Moyer
    Center for Health Care Evaluation, VA Palo Alto Health Care System and Stanford University Medical Center, Menlo Park, CA, USA
    Addiction 97:279-92. 2002
  4. pmc Effectiveness of E-self-help interventions for curbing adult problem drinking: a meta-analysis
    Heleen Riper
    Department of Clinical Psychology, VU University Amsterdam, Van der Boechorststraat 1, Amsterdam, Netherlands
    J Med Internet Res 13:e42. 2011
  5. ncbi Effectiveness and cost-effectiveness of policies and programmes to reduce the harm caused by alcohol
    Peter Anderson
    School for Public Health and Primary Care, University of Maastricht, Maastricht, The Netherlands
    Lancet 373:2234-46. 2009
  6. ncbi The association between HIV infection and alcohol use: a systematic review and meta-analysis of African studies
    Joseph C Fisher
    Interdata Inc, Sanibel, FL 33957, USA
    Sex Transm Dis 34:856-63. 2007
  7. pmc A genome-wide association study of alcohol dependence
    Laura J Bierut
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 107:5082-7. 2010
  8. ncbi The effectiveness of brief alcohol interventions in primary care settings: a systematic review
    Eileen F S Kaner
    Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK
    Drug Alcohol Rev 28:301-23. 2009
  9. pmc Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis
    Megan K Mulligan
    Waggoner Center for Alcohol and Addiction Research and Sections of Neurobiology, University of Texas, Austin, TX 78712, USA
    Proc Natl Acad Sci U S A 103:6368-73. 2006
  10. pmc A randomized controlled trial of an internet-based intervention for alcohol abusers
    John A Cunningham
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Addiction 104:2023-32. 2009

Research Grants

Detail Information

Publications293 found, 100 shown here

  1. ncbi Alcohol and public health
    Robin Room
    Centre for Social Research on Alcohol and Drugs, Stockholm University, Stockholm, Sweden
    Lancet 365:519-30. 2005
    ....
  2. ncbi Alcohol use and sexual risks for HIV/AIDS in sub-Saharan Africa: systematic review of empirical findings
    Seth C Kalichman
    Department of Psychology, University of Connecticut, 406 Babbidge Road, Storrs, CT 06269, USA
    Prev Sci 8:141-51. 2007
    ..Sexual risk reduction interventions are needed for men and women who drink and interventions should be targeted to alcohol serving establishments...
  3. ncbi Brief interventions for alcohol problems: a meta-analytic review of controlled investigations in treatment-seeking and non-treatment-seeking populations
    Anne Moyer
    Center for Health Care Evaluation, VA Palo Alto Health Care System and Stanford University Medical Center, Menlo Park, CA, USA
    Addiction 97:279-92. 2002
    ....
  4. pmc Effectiveness of E-self-help interventions for curbing adult problem drinking: a meta-analysis
    Heleen Riper
    Department of Clinical Psychology, VU University Amsterdam, Van der Boechorststraat 1, Amsterdam, Netherlands
    J Med Internet Res 13:e42. 2011
    ..Self-help interventions without professional contact to curb adult problem drinking in the community are increasingly being delivered via the Internet...
  5. ncbi Effectiveness and cost-effectiveness of policies and programmes to reduce the harm caused by alcohol
    Peter Anderson
    School for Public Health and Primary Care, University of Maastricht, Maastricht, The Netherlands
    Lancet 373:2234-46. 2009
    ..In settings with high amounts of unrecorded production and consumption, increasing the proportion of alcohol that is taxed could be a more effective pricing policy than a simple increase in tax...
  6. ncbi The association between HIV infection and alcohol use: a systematic review and meta-analysis of African studies
    Joseph C Fisher
    Interdata Inc, Sanibel, FL 33957, USA
    Sex Transm Dis 34:856-63. 2007
    ..61-2.58) for problem drinkers, a statistically significant difference (z = 2.08, P <0.04). Alcohol use was associated with HIV infection in Africa and alcohol-related interventions might help reduce further expansion of the epidemic...
  7. pmc A genome-wide association study of alcohol dependence
    Laura J Bierut
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 107:5082-7. 2010
    ..05, with odds ratios between 1.11 and 1.16. Further dissection of the alcoholism phenotype, to disentangle the influence of comorbid substance-use disorders, will be a next step in identifying ..
  8. ncbi The effectiveness of brief alcohol interventions in primary care settings: a systematic review
    Eileen F S Kaner
    Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK
    Drug Alcohol Rev 28:301-23. 2009
    ..This review aimed to assess the effectiveness of brief interventions in primary care and determine if outcomes differ between efficacy and effectiveness trials...
  9. pmc Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis
    Megan K Mulligan
    Waggoner Center for Alcohol and Addiction Research and Sections of Neurobiology, University of Texas, Austin, TX 78712, USA
    Proc Natl Acad Sci U S A 103:6368-73. 2006
    ..The present study demonstrates the use of (i) a microarray meta-analysis to analyze a behavioral phenotype (in this case, alcohol preference) and (ii) a congenic strain for identification of cis regulation...
  10. pmc A randomized controlled trial of an internet-based intervention for alcohol abusers
    John A Cunningham
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Addiction 104:2023-32. 2009
    ..The objective of this project is to conduct a randomized controlled evaluation of the internet-based Check Your Drinking (CYD) screener ( http://www.CheckYourDrinking.net)...
  11. ncbi Behavioral counseling interventions in primary care to reduce risky/harmful alcohol use by adults: a summary of the evidence for the U.S. Preventive Services Task Force
    Evelyn P Whitlock
    Oregon Evidence Based Practice Center, Kaiser Permanente Center for Health Research, and Oregon Health and Science University, Portland, Oregon 97227 1110, USA
    Ann Intern Med 140:557-68. 2004
    ..Primary health care visits offer opportunities to identify and intervene with risky or harmful drinkers to reduce alcohol consumption...
  12. ncbi The effectiveness of web-based interventions designed to decrease alcohol consumption--a systematic review
    Bridgette M Bewick
    Leeds Institute of Health Sciences, University of Leeds, Leeds, UK
    Prev Med 47:17-26. 2008
    ..To review the published literature on the effectiveness of web-based interventions designed to decrease consumption of alcohol and/or prevent alcohol abuse...
  13. ncbi A Norwegian psychiatric epidemiological study
    E Kringlen
    Department of Psychiatry, University of Oslo, Norway
    Am J Psychiatry 158:1091-8. 2001
    ..The rates for women are higher than those for men for all diagnostic categories, except for alcohol and drug abuse/dependence...
  14. pmc Fetal alcohol spectrum disorder: Canadian guidelines for diagnosis
    Albert E Chudley
    Children s Hospital, Health Sciences Centre, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Man
    CMAJ 172:S1-S21. 2005
    ..These are the first Canadian guidelines for the diagnosis of FAS and its related disabilities, developed by broad-based consultation among experts in diagnosis...
  15. pmc Gene coexpression networks in human brain identify epigenetic modifications in alcohol dependence
    Igor Ponomarev
    Waggoner Center for Alcohol and Addiction Research and the College of Pharmacy, University of Texas at Austin, Austin, Texas 78712, USA
    J Neurosci 32:1884-97. 2012
    ..Our results offer implications for epigenetic therapeutics in alcohol and drug addiction...
  16. pmc Screening, brief interventions, referral to treatment (SBIRT) for illicit drug and alcohol use at multiple healthcare sites: comparison at intake and 6 months later
    Bertha K Madras
    Harvard Medical School NEPRC, 1 Pine Hill Drive, Southborough, MA 01772, USA
    Drug Alcohol Depend 99:280-95. 2009
    ..We compared illicit drug use at intake and 6 months after drug screening and interventions were administered...
  17. pmc Effectiveness of a web-based intervention for problem drinkers and reasons for dropout: randomized controlled trial
    Marloes G Postel
    Nijmegen Institute for Scientist Practitioners in Addiction, Nijmegen, Netherlands
    J Med Internet Res 12:e68. 2010
    ..Online self-help interventions for problem drinkers show promising results, but the effectiveness of online therapy with active involvement of a therapist via the Internet only has not been examined...
  18. ncbi Combined pharmacotherapies and behavioral interventions for alcohol dependence: the COMBINE study: a randomized controlled trial
    Raymond F Anton
    Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston 29425, USA
    JAMA 295:2003-17. 2006
    ..Alcohol dependence treatment may include medications, behavioral therapies, or both. It is unknown how combining these treatments may impact their effectiveness, especially in the context of primary care and other nonspecialty settings...
  19. ncbi Nicotine, alcohol and drug dependence and psychiatric comorbidity. Results of a national household survey
    M Farrell
    National Addiction Centre, Institute of Psychiatry, King s College London, Maudsley Hospital, 4 Windsor Walk, London SE5 8AF, UK
    Br J Psychiatry 179:432-7. 2001
    ..There is a well-recognised relationship between substance use disorders and other psychiatric disorders. This relationship has been well documented in a range of population-based studies...
  20. ncbi Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence
    J C Wang
    Department of Psychiatry, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Mol Psychiatry 14:501-10. 2009
    ..association analysis of the CHRNA5-CHRNA3-CHRNB4 gene cluster in the Collaborative Study on the Genetics of Alcoholism (COGA) families to investigate the role of genetic variants in risk for alcohol dependence...
  21. ncbi Curbing problem drinking with personalized-feedback interventions: a meta-analysis
    Heleen Riper
    Innovation Centre of Mental Health and Technology, Trimbos Institute Netherlands Institute of Mental Health and Addiction, Utrecht, The Netherlands
    Am J Prev Med 36:247-55. 2009
    ..A meta-analysis was performed to examine the overall effectiveness of brief, single-session personalized-feedback interventions without therapeutic guidance...
  22. pmc Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations
    Howard J Edenberg
    Indiana University School of Medicine, Indianapolis 46202, USA
    Am J Hum Genet 74:705-14. 2004
    b>Alcoholism is a complex disease with both genetic and environmental risk factors. To identify genes that affect the risk for alcoholism, we systematically ascertained and carefully assessed individuals in families with multiple alcoholics...
  23. pmc Substance-specific and shared transcription and epigenetic changes in the human hippocampus chronically exposed to cocaine and alcohol
    Zhifeng Zhou
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD 20849, USA
    Proc Natl Acad Sci U S A 108:6626-31. 2011
    ....
  24. ncbi Widespread and sustained cognitive deficits in alcoholism: a meta-analysis
    Katherine Stavro
    Centre de Recherche Fernand Seguin, Department of Psychiatry, Faculty of Medicine, University of Montreal, Canada
    Addict Biol 18:203-13. 2013
    ..somewhat ambiguous with respect to which distinct cognitive functions are more susceptible to impairment in alcoholism and to how duration of abstinence affects cognitive recovery...
  25. ncbi Attentional bias in addictive behaviors: a review of its development, causes, and consequences
    Matt Field
    School of Psychology, University of Liverpool, Eleanor Rathbone Building, Bedford Street South, Liverpool, UK
    Drug Alcohol Depend 97:1-20. 2008
    ..We make several predictions that require testing in future research, and we discuss implications for the treatment of addictive behaviors...
  26. pmc mTOR-STAT3-notch signalling contributes to ALDH2-induced protection against cardiac contractile dysfunction and autophagy under alcoholism
    Wei Ge
    Department of Geriatrics, Xijing Hospital, Fourth Military Medical University, Xi an, China
    J Cell Mol Med 16:616-26. 2012
    ....
  27. ncbi Causal considerations on alcohol and HIV/AIDS--a systematic review
    Paul A Shuper
    Centre for Addiction and Mental Health, 33 Russell Street, Room T 518, Toronto, Ontario, Canada M5S 2S1
    Alcohol Alcohol 45:159-66. 2010
    ..The study aimed to explore the possible causal nature of the association between alcohol consumption and HIV/AIDS...
  28. pmc Quality concerns with routine alcohol screening in VA clinical settings
    Katharine A Bradley
    Health Services Research and Development HSR and D, Veterans Affairs VA Puget Sound Health Care System, 1100 Olive Way, Suite 1400, Seattle, WA 98101, USA
    J Gen Intern Med 26:299-306. 2011
    ..Alcohol screening questionnaires have typically been validated when self- or researcher-administered. Little is known about the performance of alcohol screening questionnaires administered in clinical settings...
  29. pmc Alcohol and cause-specific mortality in Russia: a retrospective case-control study of 48,557 adult deaths
    David Zaridze
    Department of Epidemiology and Prevention, N N Blokhin Russian Cancer Research Centre, Moscow, Russia
    Lancet 373:2201-14. 2009
    ..Our case-control study investigated the effects of alcohol consumption on male and female cause-specific mortality...
  30. pmc Genome-wide association study of alcohol dependence implicates a region on chromosome 11
    Howard J Edenberg
    Department of Biochemistry, Indiana University School of Medicine, Indianapolis, 46202 5122, USA
    Alcohol Clin Exp Res 34:840-52. 2010
    Alcohol dependence is a complex disease, and although linkage and candidate gene studies have identified several genes associated with the risk for alcoholism, these explain only a portion of the risk.
  31. pmc Chronic alcoholism alters systemic and pulmonary glutathione redox status
    Mary Y Yeh
    Division of Neonatology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Respir Crit Care Med 176:270-6. 2007
    ..In clinical studies, this association has been centered on depletion of pulmonary glutathione and subsequent chronic oxidant stress...
  32. ncbi Overview of the role of alcohol dehydrogenase and aldehyde dehydrogenase and their variants in the genesis of alcohol-related pathology
    David W Crabb
    Indiana University School of Medicine and Roudebush VA Medical Center, Emerson Hall Room 317, 545 Barnhill Drive, Indianapolis, IN 46202, USA
    Proc Nutr Soc 63:49-63. 2004
    ..by the ADH2*2 gene, and the inactive ALDH2*2 gene product have been conclusively associated with reduced risk of alcoholism. This association is influenced by gene-environment interactions, such as religion and national origin...
  33. ncbi Tests of causal links between alcohol abuse or dependence and major depression
    David M Fergusson
    Christchurch Health and Development Study, Department of Psychological Medicine, University of Otago, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    Arch Gen Psychiatry 66:260-6. 2009
    ..There has been a great deal of research on the comorbidity between alcohol abuse or dependence (AAD) and major depression (MD). However, it is unclear whether AAD increases the risk of MD or vice versa...
  34. ncbi Age at first alcohol use: a risk factor for the development of alcohol disorders
    D J DeWit
    Social, Prevention and Health Policy Research Department, Centre for Addiction and Mental Health, London, Ontario, Canada
    Am J Psychiatry 157:745-50. 2000
    ....
  35. ncbi Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals
    Jianwen Liu
    Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Austin, TX 78712, USA
    Neuropsychopharmacology 31:1574-82. 2006
    ..in neurodegenerative diseases such as Alzheimer's disease were significantly altered suggesting a link between alcoholism and other neurodegenerative conditions...
  36. pmc Genome-wide association study of alcohol dependence
    Jens Treutlein
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany
    Arch Gen Psychiatry 66:773-84. 2009
    ..Identification of genes that contribute to alcohol dependence will improve our understanding of the mechanisms that underlie this disorder...
  37. pmc Estimating risk of alcohol dependence using alcohol screening scores
    Anna D Rubinsky
    Northwest Health Services Research and Development Center of Excellence, VA Puget Sound Health Care System, Seattle, WA 98101, USA
    Drug Alcohol Depend 108:29-36. 2010
    ..AUDIT or AUDIT-C scores could be used to estimate the probability of past-year alcohol dependence among patients who screen positive for alcohol misuse and inform clinical decision-making...
  38. pmc Colonic microbiome is altered in alcoholism
    Ece A Mutlu
    Department of Medicine, Division of Digestive Diseases and Nutrition, Section of Gastroenterology, Rush University Medical Center, Chicago, Illinois 60612, USA
    Am J Physiol Gastrointest Liver Physiol 302:G966-78. 2012
    ..We show that the colonic mucosa-associated bacterial microbiome is altered in a subset of alcoholics. The altered microbiota composition is persistent and correlates with endotoxemia in a subgroup of alcoholics...
  39. ncbi Alcohol as a risk factor for liver cirrhosis: a systematic review and meta-analysis
    Jurgen Rehm
    Centre for Addiction and Mental Health, 33 Russell Street, Toronto, Ontario, Canada
    Drug Alcohol Rev 29:437-45. 2010
    ..To address these questions and to provide a quantitative assessment of the association between alcohol intake and risk of liver cirrhosis, we conducted a systematic review and meta-analysis of cohort and case-control studies...
  40. pmc Effects of cigarette smoking and family history of alcoholism on sweet taste perception and food cravings in women
    Marta Yanina Pepino
    Monell Chemical Senses Center, Philadelphia, Pennsylvania, USA
    Alcohol Clin Exp Res 31:1891-9. 2007
    ..and liking of sweet-tasting foods and beverages, few psychophysical studies have examined this phenomenon and none have taken into account the individual's family history of alcoholism (FH+), a predictor of heightened sweet preferences.
  41. pmc Multi-species data integration and gene ranking enrich significant results in an alcoholism genome-wide association study
    Zhongming Zhao
    Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    BMC Genomics 13:S16. 2012
    ..Integration of these heterogeneous data can be used to produce a ranked target gene list for additional investigation...
  42. ncbi The efficacy of motivational interviewing as a brief intervention for excessive drinking: a meta-analytic review
    Eirini I Vasilaki
    University of Wales, Bangor, UK
    Alcohol Alcohol 41:328-35. 2006
    ..1) To examine whether or not motivational interviewing (MI) is more efficacious than no intervention in reducing alcohol consumption; (2) to examine whether or not MI is as efficacious as other interventions...
  43. pmc Meta-analysis of randomized control trials addressing brief interventions in heavy alcohol drinkers
    A I Wilk
    Department of Medicine, University of Wisconsin Medical School, Madison, USA
    J Gen Intern Med 12:274-83. 1997
    ..Brief intervention is a low-cost, effective preventive measure for heavy drinkers in outpatient settings...
  44. pmc Genome-wide association study of alcohol dependence implicates KIAA0040 on chromosome 1q
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Neuropsychopharmacology 37:557-66. 2012
    ..SAGE (the Study of Addiction: Genetics and Environment) and COGA (the Collaborative Study on the Genetics of Alcoholism) genome-wide association study (GWAS) data sets reported several risk loci for alcohol dependence (AD), which ..
  45. pmc Altered fronto-cerebellar connectivity in alcohol-naïve youth with a family history of alcoholism
    Megan M Herting
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Neuroimage 54:2582-9. 2011
    ..MRI (fcMRI) to examine fronto-cerebellar circuitry in 13 alcohol-naïve, at-risk youth with a family history of alcoholism (FH+) and 14 age-matched controls...
  46. pmc Risky decision-making: an FMRI study of youth at high risk for alcoholism
    Anita Cservenka
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, USA
    Alcohol Clin Exp Res 36:604-15. 2012
    Adolescents with a family history of alcoholism (FHP) are at risk for developing an alcohol use disorder (AUD), and some studies indicate that FHP individuals show deficits in executive functioning...
  47. ncbi Clinical and pathological features of alcohol-related brain damage
    Natalie M Zahr
    Department of Psychiatry and Behavioral Sciences, 401 Quarry Road, Stanford University, Stanford, CA 94305, USA
    Nat Rev Neurol 7:284-94. 2011
    ..brain structure and function in the absence of more discrete and well-characterized neurological concomitants of alcoholism such as WE and KS...
  48. ncbi Alcoholism: a systems approach from molecular physiology to addictive behavior
    Rainer Spanagel
    Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Physiol Rev 89:649-705. 2009
    ..Alcohol-related diseases, especially alcoholism, are the result of cumulative responses to alcohol exposure, the genetic make-up of an individual, and the ..
  49. pmc The genetic basis of alcoholism: multiple phenotypes, many genes, complex networks
    Tatiana V Morozova
    Department of Biology, Box 7617, North Carolina State University, Raleigh, NC 27695, USA
    Genome Biol 13:239. 2012
    b>Alcoholism is a significant public health problem. A picture of the genetic architecture underlying alcohol-related phenotypes is emerging from genome-wide association studies and work on genetically tractable model organisms.
  50. ncbi The FAST Alcohol Screening Test
    Ray Hodgson
    University of Wales College of Medicine, Lansdowne Hospital, Cardiff CF11 8PL, UK
    Alcohol Alcohol 37:61-6. 2002
    ..The FAST questionnaire is quick to administer, since >50% of patients are categorized using just one question...
  51. pmc Glial and glutamatergic markers in depression, alcoholism, and their comorbidity
    Jose Javier Miguel-Hidalgo
    Division of Neurobiology and Behavior Research, Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS 39216, USA
    J Affect Disord 127:230-40. 2010
    ..of glutamatergic neurotransmission in the prefrontal cortex (PFC) may contribute to the pathophysiology of alcoholism and major depressive disorder (MDD)...
  52. ncbi Opioids and alcoholism
    L M Oswald
    Departments of Medicine and Psychiatry, The Johns Hopkins University, School of Medicine, Ross Research Building, Room 863, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Physiol Behav 81:339-58. 2004
    ..far from conclusive, evidence implicating the endogenous opioid system in the development and maintenance of alcoholism is growing...
  53. ncbi Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats
    Zachary A Rodd
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202 4887, United States
    Pharmacol Biochem Behav 89:481-98. 2008
    ..g., Cav2, Nrxn3, Gabrb2, Gad1, Homer1) and homeostasis (S100b, Prkca, Ftl1) categories. Overall, the results suggest that changes in gene expression in the ACB of iP rats are associated with the reinforcing effects of EtOH...
  54. pmc The role of amygdaloid brain-derived neurotrophic factor, activity-regulated cytoskeleton-associated protein and dendritic spines in anxiety and alcoholism
    Sachin Moonat
    Department of Psychiatry, University of Illinois at Chicago and Jesse Brown VA Medical Center, 820 S Damen Avenue M C 151 Chicago, IL 60612, USA
    Addict Biol 16:238-50. 2011
    ....
  55. pmc Alcoholism and inflammation: neuroimmunology of behavioral and mood disorders
    Keith W Kelley
    Integrative Immunology and Behavior Program, Department of Animal Sciences, College of ACES, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Brain Behav Immun 25:S13-20. 2011
    ..and humans now supports the conclusion that the innate immune system is an important physiological link between alcoholism and major depressive disorders...
  56. pmc Differential activity by polymorphic variants of a remote enhancer that supports galanin expression in the hypothalamus and amygdala: implications for obesity, depression and alcoholism
    Scott Davidson
    School of Medical Sciences, Institute of Medical Sciences, Foresterhill, University of Aberdeen, Aberdeen, Scotland, UK
    Neuropsychopharmacology 36:2211-21. 2011
    ..1 as a PVN and amygdala specific enhancer represent a significant advance in our ability to understand alcoholism, obesity and major depressive disorder.
  57. pmc The serotonin transporter gene and risk for alcohol dependence: a meta-analytic review
    R Kathryn McHugh
    Department of Psychology, Boston University, Boston, MA 02215, USA
    Drug Alcohol Depend 108:1-6. 2010
    ..Therefore, although our review indicates that there is a significant association between 5HTTLPR and alcohol dependence diagnosis, this result should be interpreted with caution...
  58. pmc Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis
    Stuart Macgregor
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Hum Mol Genet 18:580-93. 2009
    ..The absence of study-wide significant effects on AD results from the low P-value required when testing multiple single nucleotide polymorphisms and phenotypes...
  59. ncbi Comparing alcohol consumption in central and eastern Europe to other European countries
    Svetlana Popova
    Social, Prevention and Health Policy Research Department, Centre for Addiction and Mental Heath, 33 Russell Street, Toronto, Ontario, Canada
    Alcohol Alcohol 42:465-73. 2007
    ....
  60. ncbi Teenage drinking and the onset of alcohol dependence: a cohort study over seven years
    Yvonne A Bonomo
    Centre for Adolescent Health, Murdoch Children s Research Institute
    Addiction 99:1520-8. 2004
    ..To determine whether adolescent alcohol use and/or other adolescent health risk behaviour predisposes to alcohol dependence in young adulthood...
  61. pmc Mechanisms of neurodegeneration and regeneration in alcoholism
    Fulton T Crews
    Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, NC 27599, USA
    Alcohol Alcohol 44:115-27. 2009
    ..g. brain regeneration. Efforts are made to relate preclinical studies to human studies...
  62. ncbi Still a difficult business? Negotiating alcohol-related problems in general practice consultations
    Tim Rapley
    University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Soc Sci Med 63:2418-28. 2006
    ..As the definition of what could constitute abnormal alcohol consumption has expanded, so the range of consultations that they may have to negotiate these difficulties in has also expanded...
  63. pmc The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants
    Howard J Edenberg
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Alcohol Res Health 30:5-13. 2007
    ..Which ADH or ALDH alleles a person carries influence his or her level of alcohol consumption and risk of alcoholism. Researchers to date primarily have studied coding variants in the ADH1 B, ADH1C, and ALDH2 genes that are ..
  64. ncbi Effectiveness of the derived Alcohol Use Disorders Identification Test (AUDIT-C) in screening for alcohol use disorders and risk drinking in the US general population
    Deborah A Dawson
    Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 9304, USA
    Alcohol Clin Exp Res 29:844-54. 2005
    ..The three consumption questions from the Alcohol Use Disorders Identification Test (AUDIT-C) are increasingly used as a screener for alcohol use disorders (AUDs) and risk drinking...
  65. ncbi Screening and brief intervention for hazardous drinking in an HMO: effects on medical care utilization
    D K Freeborn
    Kaiser Permanente Center for Health Research, Portland, OR 97227, USA
    J Behav Health Serv Res 27:446-53. 2000
    ..7 vs. 6.6 days; p = .37). Although brief interventions to reduce hazardous drinking may potentially reduce medical care utilization, more evidence is needed to substantiate their practicality and cost-effectiveness...
  66. ncbi Alcohol and adult neurogenesis: roles in neurodegeneration and recovery in chronic alcoholism
    Kimberly Nixon
    College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, USA
    Hippocampus 16:287-95. 2006
    ..Chronic alcoholism is a progressive neurodegenerative disease while the person continues to abuse alcohol, though clinical and ..
  67. ncbi Additive effect of stress and drug cues on reinstatement of ethanol seeking: exacerbation by history of dependence and role of concurrent activation of corticotropin-releasing factor and opioid mechanisms
    Xiu Liu
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 22:7856-61. 2002
    ..The results document that stress and drug-related environmental stimuli interact to augment the resumption of drug seeking after extinction and suggest that this effect results from concurrent activation of opioid and CRF transmission...
  68. pmc Varenicline reduces alcohol self-administration in heavy-drinking smokers
    Sherry A McKee
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Biol Psychiatry 66:185-90. 2009
    ..Varenicline, a partial nicotinic agonist with high affinity for the alpha4beta2 nAChR receptor, reduced ethanol intake in rodents. We aimed to test whether varenicline would reduce alcohol consumption and alcohol craving in humans...
  69. ncbi Internet therapy versus internet self-help versus no treatment for problematic alcohol use: A randomized controlled trial
    Matthijs Blankers
    Amsterdam Institute for Addiction Research, Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Consult Clin Psychol 79:330-41. 2011
    ..The current study examined the effectiveness of Internet-based therapy (therapy alcohol online; TAO) and Internet-based self-help (self-help alcohol online; SAO) for problematic alcohol users...
  70. ncbi Retraining automatic action tendencies changes alcoholic patients' approach bias for alcohol and improves treatment outcome
    Reinout W Wiers
    Department of Psychology, University of Amsterdam, Amsterdam, The Netherlands
    Psychol Sci 22:490-7. 2011
    ..Patients in the experimental conditions showed better treatment outcomes a year later. These findings indicate that a short intervention can change alcoholics' automatic approach bias for alcohol and may improve treatment outcome...
  71. pmc Genetic factors influencing alcohol dependence
    R D Mayfield
    Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Austin, TX 78712, USA
    Br J Pharmacol 154:275-87. 2008
    ..Moreover, the information offered here addresses the importance of more general issues regarding genetics and gene expression related to alcohol abuse and dependence...
  72. pmc A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations
    Penelope A Lind
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res Hum Genet 13:10-29. 2010
    ..Further studies will be required before the detailed causes of comorbidity between AD and ND are understood...
  73. pmc A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications
    Andrew C Heath
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Biol Psychiatry 70:513-8. 2011
    Given moderately strong genetic contributions to variation in alcoholism and heaviness of drinking (50% to 60% heritability) with high correlation of genetic influences, we have conducted a quantitative trait genome-wide association study ..
  74. ncbi The 12-month prevalence and trends in DSM-IV alcohol abuse and dependence: United States, 1991-1992 and 2001-2002
    Bridget F Grant
    Division of Intramural Clinical and Biological Research, Department of Health and Human Services, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892 9304, USA
    Drug Alcohol Depend 74:223-34. 2004
    ....
  75. ncbi Association of the DRD2 gene Taq1A polymorphism and alcoholism: a meta-analysis of case-control studies and evidence of publication bias
    M R Munafò
    Department of Experimental Psychology, University of Bristol, Bristol, UK
    Mol Psychiatry 12:454-61. 2007
    We investigated the association of the dopamine D2 receptor (DRD2) Taq1A polymorphism and alcoholism, using meta-analytic techniques, and specifically undertook an investigation of possible publication bias...
  76. pmc Risks of combined alcohol/medication use in older adults
    Alison A Moore
    UCLA Integrated Substance Abuse Programs, Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1687, USA
    Am J Geriatr Pharmacother 5:64-74. 2007
    ..Many older adults (ie, those aged >65 years) drink alcohol and use medications that may be harmful when consumed together...
  77. ncbi Alcohol dependence is associated with blunted dopamine transmission in the ventral striatum
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, USA
    Biol Psychiatry 58:779-86. 2005
    ..This study measured D2 receptors and dopamine transmission in human alcohol-dependent (AD) subjects using positron emission tomography (PET) and [11C]raclopride...
  78. pmc Biomarker testing to estimate under-reported heavy alcohol consumption by persons with HIV initiating ART in Uganda
    Judith A Hahn
    University of California, San Francisco, CA 94143 0811, USA
    AIDS Behav 14:1265-8. 2010
    ..These results suggest likely under-report in those reporting abstaining and current drinking. Improved identification of heavy alcohol consumption is needed for research and clinical purposes...
  79. ncbi Alcohol abuse in individuals exposed to trauma: a critical review
    S H Stewart
    Department of Psychology, Dalhousie University, Halifax Nova, Scotia, Canada
    Psychol Bull 120:83-112. 1996
    ..between exposure to traumatic events and alcohol problems, and particularly between the diagnoses of PTSD and alcoholism, the author discusses various factors, theories, and possible mechanisms to account for these associations...
  80. pmc The neurobiology of alcohol consumption and alcoholism: an integrative history
    Boris Tabakoff
    University of Colorado School of Medicine, MS8303, 12800 E 19th Ave, Aurora, CO 80045, USA Electronic address
    Pharmacol Biochem Behav 113:20-37. 2013
    ..neurobiological predisposition to consume alcohol (ethanol) and to transition to uncontrolled drinking behavior (alcoholism), as well as studies of the effects of alcohol on brain function, started a logarithmic growth phase after the ..
  81. ncbi Association of polymorphisms in nicotinic acetylcholine receptor alpha 4 subunit gene (CHRNA4), mu-opioid receptor gene (OPRM1), and ethanol-metabolizing enzyme genes with alcoholism in Korean patients
    Soon Ae Kim
    Department of Pharmacology, Eulji University School of Medicine, 143 5 Yongdu Dong, Jung Gu, Daejeon, 301 832, Korea
    Alcohol 34:115-20. 2004
    ..To identify the association between the CfoI polymorphism of the CHRNA4 and alcoholism, we examined distribution of genotypes and allele frequencies in Korean patients diagnosed with alcoholism (n = ..
  82. ncbi Alcohol consumption and major depression in the general population: the critical importance of dependence
    Andrew Bulloch
    Department of Community Health Sciences, University of Calgary, Calgary, Canada
    Depress Anxiety 29:1058-64. 2012
    ..We evaluated the incidence of MDE in relation to different patterns of alcohol use, and examined the incidence of alcohol misuse in respondents with and without MDE...
  83. pmc Ethanol and acetaldehyde action on central dopamine systems: mechanisms, modulation, and relationship to stress
    Miriam Melis
    B B Brodie Department of Neuroscience, University of Cagliari, Monserrato, Cagliari 09042, Italy
    Alcohol 43:531-9. 2009
    ..by acetaldehyde, and that the interaction between stress and alcohol could play a role in susceptibility to alcoholism. The link between acetaldehyde and ethanol actions on brain reward pathways may provide a new avenue for the ..
  84. pmc An evaluation of the impact of a large reduction in alcohol prices on alcohol-related and all-cause mortality: time series analysis of a population-based natural experiment
    Kimmo Herttua
    Population Research Unit, Department of Sociology, University of Helsinki, Helsinki, Finland
    Int J Epidemiol 40:441-54. 2011
    ....
  85. ncbi SBIRT in emergency care settings: are we ready to take it to scale?
    Edward Bernstein
    Department of Emergency Medicine, Boston University School of Medicine and the Department of Community Health Sciences, Boston University School of Public Health, Boston, MA, USA
    Acad Emerg Med 16:1072-7. 2009
    ....
  86. pmc A comparison of selected quantitative trait loci associated with alcohol use phenotypes in humans and mouse models
    Cindy L Ehlers
    Department of Molecular and Integrative Neurosciences, The Scripps Research Institute, La Jolla, CA 92037, USA
    Addict Biol 15:185-99. 2010
    ....
  87. ncbi Insomnia, alcoholism and relapse
    Kirk J Brower
    University of Michigan Addiction Research Center, Ann Arbor, MI 48108, USA
    Sleep Med Rev 7:523-39. 2003
    Insomnia and alcoholism are significantly associated in community surveys and patient samples. Insomnia occurs in 36-72% of alcoholic patients and may last for weeks to months after initiating abstinence from alcohol...
  88. ncbi Increased documented brief alcohol interventions with a performance measure and electronic decision support
    Gwen T Lapham
    Health Services Research and Development, VA Puget Sound Health Care System, Seattle, WA 98101, USA
    Med Care 50:179-87. 2012
    ..Alcohol screening and brief interventions (BIs) are ranked the third highest US prevention priority, but effective methods of implementing BI into routine care have not been described...
  89. pmc Predicting alcohol consumption in adolescence from alcohol-specific and general externalizing genetic risk factors, key environmental exposures and their interaction
    K S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA
    Psychol Med 41:1507-16. 2011
    ..We have limited knowledge of how these risk factors inter-relate through development...
  90. ncbi Chronic alcohol abuse is associated with an increased incidence of acute respiratory distress syndrome and severity of multiple organ dysfunction in patients with septic shock
    Marc Moss
    Department of Medicine, Division of Pulmonary and Critical Care, Emory University School of Medicine, Atlanta, GA 30335, USA
    Crit Care Med 31:869-77. 2003
    ..The goal of this study was to determine the effects of chronic alcohol abuse on the incidence and severity of the acute respiratory distress syndrome and multiple organ dysfunction syndrome in patients with septic shock...
  91. pmc Transcriptional control of maladaptive and protective responses in alcoholics: a role of the NF-κB system
    Tatjana Yakovleva
    Division of Biological Research on Drug Dependence, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden
    Brain Behav Immun 25:S29-38. 2011
    ..Although further verification is needed, we speculate that NF-κB-driven neuroinflammation and disruption to neuroplasticity play a significant role in regulating alcohol dependence and cognitive impairment...
  92. ncbi A functional polymorphism of the mu-opioid receptor gene is associated with naltrexone response in alcohol-dependent patients
    David W Oslin
    Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania, 3535 Market Street, Room 3002, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 28:1546-52. 2003
    ..If replicated, these results would help to identify alcohol-dependent individuals who may be most likely to respond to treatment with naltrexone...
  93. ncbi Change over time in alcohol consumption in control groups in brief intervention studies: systematic review and meta-regression study
    Richard J Jenkins
    Centre for Paediatric Epidemiology and Biostatistics, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, United Kingdom
    Drug Alcohol Depend 100:107-14. 2009
    ..Further investigations may yield novel insights into the nature of behaviour change with potential to inform brief interventions design...
  94. ncbi Ethanol and brain damage
    Clive Harper
    Department of Pathology, University of Sydney, New South Wales, Australia 2006
    Curr Opin Pharmacol 5:73-8. 2005
    ..The development of high-throughput, non-hypothesis-driven approaches using DNA microarrays and proteomics might also provide clues to this important problem...
  95. pmc A randomized pilot study of the Engaging Moms Program for family drug court
    Gayle A Dakof
    Center for Treatment Research on Adolescent Drug Abuse, Department of Epidemiology and Public Health, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    J Subst Abuse Treat 38:263-74. 2010
    ..EMP showed equal or better improvement than ICMS on all outcomes. The results suggest that EMP in family drug court is a viable and promising intervention approach to reduce maternal addiction and child maltreatment...
  96. pmc Chronic alcohol neuroadaptation and stress contribute to susceptibility for alcohol craving and relapse
    George R Breese
    Bowles Center for Alcohol Research and the UNC Neuroscience Center, UNC School of Medicine, Chapel Hill, NC 27599, USA
    Pharmacol Ther 129:149-71. 2011
    b>Alcoholism is a chronic relapsing disorder. Major characteristics observed in alcoholics during an initial period of alcohol abstinence are altered physiological functions and a negative emotional state...
  97. ncbi Familial transmission of substance dependence: alcohol, marijuana, cocaine, and habitual smoking: a report from the Collaborative Study on the Genetics of Alcoholism
    L J Bierut
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Gen Psychiatry 55:982-8. 1998
    b>Alcoholism and substance dependence frequently co-occur. Accordingly, we evaluated the familial transmission of alcohol, marijuana, and cocaine dependence and habitual smoking in the Collaborative Study on the Genetics of Alcoholism.
  98. pmc Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample
    Kenneth S Kendler
    Virginia Institute of Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University School of Medicine, Richmond, 23298, USA
    Alcohol Clin Exp Res 35:963-75. 2011
    ..While genetic influences on alcohol dependence (AD) are substantial, progress in the identification of individual genetic variants that impact on risk has been difficult...
  99. ncbi Factors influencing inquiry about patients' alcohol consumption by primary health care physicians: qualitative semi-structured interview study
    Marja Aira
    Department of Public Health and General Practice, University of Kuopio, Finland
    Fam Pract 20:270-5. 2003
    ..However, primary care physicians are still not screening for and intervening sufficiently in their patients' alcohol misuse...
  100. ncbi Post-soviet placebos: epistemology and authority in Russian treatments for alcoholism
    Eugene Raikhel
    Department of Comparative Human Development, University of Chicago, 5730 South Woodlawn Avenue, Chicago, IL 60637, USA
    Cult Med Psychiatry 34:132-68. 2010
    The dominant modalities of treatment for alcoholism in Russia are suggestion-based methods developed by narcology-the subspecialty of Russian psychiatry which deals with addiction...
  101. pmc Drug use and dependence in cocaine dependent subjects, community-based individuals, and their siblings
    Laura Jean Bierut
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Drug Alcohol Depend 95:14-22. 2008
    ....

Research Grants74

  1. Sertraline Pharmacotherapy for Alcoholism Subtypes
    Henry Kranzler; Fiscal Year: 2007
    ..those with demonstrated acceptability to prescribers, if medications are to play an important role in alcoholism treatment...
  2. Novel Mitochondrial Mechanisms of Ethanol-Induced Cardiac Injury in Aged Females
    DONNA HOPE KORZICK; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): ABSTRACT Sex differences in the cardiovascular response to alcoholism exist such that women are apparently more sensitive to the toxic effects of alcohol vs men, although the mechanisms which underlie ..
  3. Ethanol Regulation of Serum Glucocorticoid Kinase I
    BLAIR N COSTIN; Fiscal Year: 2012
    ..meet the criteria for ethanol abuse and more than half of American adults have a family member affected by alcoholism. The neuroadaptations that occur leading to and following ethanol dependence and their mechanisms have yet to be ..
  4. Cellular Signaling in Alcoholism
    Subhash C Pandey; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Alcoholism is a major health concern in the VA population as well as in the general population...
  5. Efficacy of Yoga for Treatment-Resistant PTSD
    Bessel Van der Kolk; Fiscal Year: 2010
    ..a childhood history of trauma, and because people with such histories have a 4-12 times greater risk to develop alcoholism, depression, drug abuse, and to make suicide attempts, a 2-4 times greater risk for smoking, a 1.4- 1...
  6. DNA Methylation in Ethanol Drinking Behavior
    David P Gavin; Fiscal Year: 2013
    ..Ultimately, these studies will identify novel molecular targets in the actions of ethanol and ethanol drinking behavior, and promote the development of pharmacotherapy for alcoholism.
  7. Signaling Mechanisms in Alcohol Drinking Behaviors
    Subhash C Pandey; Fiscal Year: 2013
    ..However, the epigenetic and signaling mechanisms that may be involved in the comorbidity of anxiety and alcoholism remain unclear...
  8. Design and Synthesis of Anxioselective Anxiolytics
    James M Cook; Fiscal Year: 2010
    ..in many anxiety disorders including panic disorder, epilepsy, hypersensitive behavior, phobias, schizophrenia, alcoholism, Anglemans syndrome and Rhetts syndrome, as well as effects which lead to/or complicate drug abuse...
  9. Validation of a functional MRI-based reward processing task as a non-invasive too
    MARY LOUISE PHILLIPS; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Psychiatric disorders such as alcoholism, drug dependence, depression, bipolar disorder and attention deficit disorder affect almost a fifth of Americans ..
  10. Potentiation of Glycine Receptors by Ethanol
    LUIS GERARDO AGUAYO; Fiscal Year: 2010
    ..Therefore, these results may contribute to the development of new treatments for alcoholism. PUBLIC HEALTH RELEVANCE Excessive consumption of ethanol is a main health-related problem in the US and world ..
  11. Histone Methylation: a role in excessive ethanol intake and self-administration
    Jennifer A Rinker; Fiscal Year: 2012
    ..as these types of behaviors can lead to a host of adverse health consequences, including the development of alcoholism, which costs billions of dollars in annual healthcare expenditures and other related costs...
  12. MECHANISM OF ENDOTOXIN ABSORPTION IN ALCOHOLISM
    Radhakrishna Rao; Fiscal Year: 2013
    ..The outcome of these studies is expected to provide knowledge to develop new therapies in the treatment of alcoholic liver disease and alcohol-induced tissue injury in pancreas and lung. ..
  13. Genetic Vulnerability to Alcohol Withdrawal and Genetically Correlated Behaviors
    Kari J Buck; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Alcoholism is a common condition found in veterans and alcohol abuse is a complicating factor in most chronic medical and psychiatric illnesses...
  14. Alcohol &Antiretrovirals in HIV Infection, Oxidative Stress and Liver Disease
    Marianna K Baum; Fiscal Year: 2012
    ..DNA damage and increased oxidative stress produced by antiretroviral treatment (ART) may be aggravated by alcoholism, as chronic alcohol consumption is associated with increased hepatic oxidative stress and reduced antioxidant ..
  15. Chronic ethanol, B cell competence and lymphoid integrity
    Thomas J Waldschmidt; Fiscal Year: 2010
    ..In order to better mimic chronic alcoholism, as well as fetal alcohol exposure, we have exploited the ethanol-in-drinking-water mouse model that allows for ..
  16. Identification and Validation of Alcohol Biomarker Signatures by Proteomics
    Emanuel Rubin; Fiscal Year: 2010
    ..Functionally, alcoholic cardiomyopathy (ACM) is characterized by reversible and irreversible alterations. Alcoholism also causes atrophy of skeletal muscle, termed alcoholic myopathy, which is closely correlated with ACM...
  17. Alcoholic Liver Dysfunction Potentiation by Hyperlipidemia and Cigarette Smoke
    SHANNON MARIE BAILEY; Fiscal Year: 2013
    ..area will help medical professionals better understand the causes of liver disease and lead to the discovery of new treatments for patients suffering from liver diseases associated with diabetes, obesity, hepatitis C, and alcoholism.
  18. Molecular Analysis of Alcohol Effects on Human Oral Epithelium Cells'Epigenome
    Alison Urvalek; Fiscal Year: 2013
    ..National Institute of Dental and Craniofacial Research (NIDCR) and the National Institute of Alcohol Abuse and Alcoholism (NIAAA) by identifying some of the initial steps during carcinogen and alcohol mediated oral carcinogenesis, ..
  19. Role of AIE in Epigenetic and Behavioral Changes at Adulthood
    Subhash C Pandey; Fiscal Year: 2013
    ..BNST) circuitries, has been shown to be involved in the processes that regulate emotion, anxiety, and alcoholism. Ethanol produces anxiolytic effects in both animals and humans and adolescents are less sensitive to the ..
  20. NeuroMolecular consequences of adolescent binge drinking
    Toni R Pak; Fiscal Year: 2013
    ..Furthermore, these studies conform to the 5-year strategic plan of the National Institutes of Alcoholism and Alcohol Abuse (NIAAA) to take a "lifespan perspective" on alcohol abuse and determine how alcohol abuse can ..
  21. Dissecting the Role of Unfolded Protein Response in Alcoholic Liver Disease
    Ling Qi; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Alcoholism threatens the health of millions of Americans in the United States...
  22. MODULATION OF ALCOHOL REINFORCEMENT
    Christopher L Cunningham; Fiscal Year: 2012
    ..and neurobiological processes that contribute to the etiology, maintenance, elimination and relapse of alcoholism. The general experimental strategy involves study of ethanol's motivational effects in animals (mice) using ..
  23. GENETIC AND ENVIRONMENTAL CONTRIBUTIONS TO THE COURSE OF ALCOHOL USE IN WOMEN
    Carolyn E Sartor; Fiscal Year: 2013
    ..Adolescent Female Twin Study (MOAFTS) and 535 female participants from the Missouri Family Study, a high risk alcoholism family study oversampled for African-American ethnicity (50%);and b) 2,632 female twins from an Australian twin ..
  24. Alcohol and Breast Cancer
    Jia Luo; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Alcoholism, alcohol abuse, and the medical complications of excessive drinking are major world-wide health problems. Alcohol is a tumor promoter...
  25. Cell Death in Alcoholic Heart and Muscle
    Emanuel Rubin; Fiscal Year: 2013
    ..In fact, the most common cause of cardiomyopathy with congestive heart failure is chronic alcoholism. However, the pathogenesis of these conditions still remains obscure...
  26. Alcohol, Glial Gene Expression and the Heat Shock Pathway
    Neil L Harrison; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Alcoholism is a major public health problem in the US...
  27. 16th ISBRA Conference
    Edward P Riley; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The International Society for Biomedical Research on Alcoholism (ISBRA) Congress is the premier worldwide scientific meeting devoted to alcohol research...
  28. Addiction-like behavior in models of mood disorders: role of CLOCK and NPAS2
    Colleen A McClung; Fiscal Year: 2013
    ..Furthermore, people with genetic sleep disorders involving the circadian clock are also more vulnerable to alcoholism and addiction...
  29. Models for?functional evaluation of?CHRN polymorphisms
    Beverly H Koller; Fiscal Year: 2012
    ..The genetic contribution to addictions, including nicotine dependence, alcoholism and addiction to drugs such as cocaine, has been well established in studies of cohorts of twins...
  30. Functional genetic evolution of human brain and behavior
    Eric J Vallender; Fiscal Year: 2013
    ..MAOA has been associated with neuropsychiatric and addiction disorders including alcoholism, depression, and autism among others and is a target for widely prescribed anti-depression and anti-anxiety ..
  31. Role for tissue-type plasminogen activator in suppression of hepatic fibrosis
    Liang I Kang; Fiscal Year: 2013
    ..g. NALFD, chronic hepatitis, genetic disorders, and alcoholism)...
  32. Effects of Alcohol on Stem Cells in the Adult Brain
    Michael W Miller; Fiscal Year: 2012
    ..b>Alcoholism is a pressing issue not only for its genetic implications, but also because alcohol abuse often develops in ..
  33. Functional Anatomy of REM Sleep: Brainstem-Control
    Gerald A Marks; Fiscal Year: 2013
    ..Studies have shown that REM sleep measures during treatment for alcoholism are significant factors predicting risk of relapse...
  34. Complement and cytokine network in liver regeneration
    John D Lambris; Fiscal Year: 2011
    ..have evolved as an efficient adaptation that allows this organ to cope with many hazardous conditions, including alcoholism, drug overdose, and viral hepatitis...
  35. ADULT STEM CELL SUPPRESSION DUE TO ALCOHOL INDUCED MICROENVIRONMENT ALTERATIONS
    Mandi J Lopez; Fiscal Year: 2010
    b>Alcoholism and alcohol abuse affect at least 14 million Americans. Chronic alcohol consumption is associated with osteoporosis and an increased rate of lumbar spinal fractures...
  36. Is Maternal Iron Status a Risk Factor in Fetal Alcohol Syndrome?
    Susan M Smith; Fiscal Year: 2010
    ..We hypothesize that the parity factor/s reflect the micronutrient deficiencies that frequently accompany alcoholism. This R21 proposal focuses specifically on iron deficiency (ID), the most common nutrient deficiency in pregnant ..
  37. Genetics of Alcohol Sensitivity in Drosophila
    Trudy F Mackay; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Alcohol abuse and alcoholism are significant public health problems. In the United States, alcoholism affects approximately 14 million people at a health care cost of $184 billion per year...
  38. DORSAL RAPHE NUCLEUS SEROTONIN NEURONS IN ALCOHOLISM
    Mark D Underwood; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Alcoholism is one of the most costly drug use problems in the United States and can result in psychiatric and medical diseases and even ultimately in death...
  39. Liver Inflammation and Injury: Molecular Mechanisms
    Mario Chojkier; Fiscal Year: 2013
    ..B and C, rejection of a transplanted liver, auto-immune hepatitis, fatty liver of obesity and diabetes and alcoholism. Additional knowledge gained by this work will add to the understanding of liver inflammation and injury may ..
  40. Neuroimmune Factors and Co-Morbid Fear, Depression and Alcohol Consumption
    Michael S Fanselow; Fiscal Year: 2010
    ..Thus, neuroimmune factors lay at a nexus of PTSD, depression and alcoholism. It is not known what mediates these long-term stress-induced changes, but stress can produce a neuroimmune ..
  41. Hepatocyte Clock and Alcoholic Fatty Liver Injury
    SHANNON MARIE BAILEY; Fiscal Year: 2011
    ..area will help medical professionals better understand the causes of liver disease and lead to the discovery of new treatments for patients suffering from liver diseases associated with diabetes, obesity, hepatitis C, and alcoholism.
  42. CNS EFFECTS OF ALCOHOL: CELLULAR NEUROBIOLOGY
    George F Koob; Fiscal Year: 2013
    ..3) A particularly vulnerable local human clinical population has a phenotype of alcoholism that displays this transition from bingeing to dependence in young adulthood, allowing us to translate our ..
  43. Ethanol Dependence and Kappa Receptor Antagonists
    MARC REZA AZAR; Fiscal Year: 2011
    In the US, alcoholism is a serious disorder that will affect 14% of the population at some point in their lives. 100,000 US citizens will die of alcoholism each year from direct and indirect causes at a cost of $166 billion per year...
  44. Neuroimaging mechanisms of overlap between alcoholism and bipolar disorder
    JAMES JOSEPH PRISCIANDARO; Fiscal Year: 2013
    ..Development Award (K23), through the National Institutes of Health-National Institute on Alcohol Abuse and Alcoholism (NIH/NIAAA), to facilitate his career as an independent investigator conducting patient-oriented research in ..
  45. The Role of CLOCK in Ethanol-Related Behaviors
    Angela Renee Ozburn; Fiscal Year: 2012
    ..I am motivated, diligent, and dedicated to advancing the treatment of alcoholism. This plan, combined with the excellent group of researchers at UTSW will allow me to obtain my goals outlined ..
  46. Chronic alcohol and pulmonary immunity
    Kevin L Legge; Fiscal Year: 2010
    Chronic alcoholism increases the incidence and severity of respiratory diseases and infections. Indeed, alcoholics compared to non-alcoholic individuals have increased mortality and morbidity during bacterialpneumonias...
  47. Kainate receptor signaling in striatal synaptic function and plasticity
    John Marshall; Fiscal Year: 2012
    ..estimated to affect 1-2% of the population, making it the fourth most common mental illness after depression, alcoholism and social anxiety disorder...
  48. The Role of Autophagy in Alcohol-Induced Liver Injury
    Wen Xing Ding; Fiscal Year: 2010
    ..Cirrhosis is the eleventh leading cause of death in the United States. Alcohol abuse and alcoholism accounts for approximately 50 % of all death induced by liver cirrhosis...
  49. Quantitative Comparisons between genotypes and model species
    Lauren M McIntyre; Fiscal Year: 2013
    ..The effects of alcohol and risk for alcoholism have a strong and complex genetic component, but are also mediated by the environment...
  50. Adolescent Binge Drinking Increases Adult Alcohol Intake: Glutamate Mechanisms
    Deborah A Finn; Fiscal Year: 2013
    ..However, while alcoholism and alcohol use disorder contribute to health problems in the US veteran population, the physiological ..
  51. Alcoholism and Brain Functions
    MARLENE OSCAR BERMAN; Fiscal Year: 2013
    ..The effects of alcoholism on the brain are particularly critical because of the potential impact on the facilitation and maintenance of ..
  52. HYPOTHALAMIC PEPTIDES IN THE CONTROL OF ALCOHOL INTAKE
    Sarah F Leibowitz; Fiscal Year: 2013
    ..As pharmacological therapies used to treat alcoholism act in part through these neurochemical control systems, we will test whether medications more effective in ..
  53. Neurochemical &Behavioral Correlates of ETOH Effects
    Rueben A Gonzales; Fiscal Year: 2013
    ..predoctoral and two postdoctoral fellows who will be broadly and intensively trained to conduct research on alcoholism. This program has a long history of training predoctoral and postdoctoral students in alcoholism research to ..
  54. Adipose Tissue Lipolysis and Alcoholic Fatty Liver
    Zhanxiang Zhou; Fiscal Year: 2013
    ..fat accumulation in the liver, a significant decrease in fat mass (lipoatrophy) has been documented in chronic alcoholism. Our preliminary studies demonstrated a negative correlation between adipose tissue mass and liver fat in mice ..
  55. Neuroimaging in the Oklahoma Family Health Patterns Project
    William R Lovallo; Fiscal Year: 2013
    ..goal is to develop a better understanding of central nervous system characteristics of persons at risk for alcoholism. Many Veteran alcoholics begin heavy drinking during their time in military service, and the VA is responsible ..
  56. Characterization of the Transcriptome in an Emerging Model for Social Behavior
    James W Thomas; Fiscal Year: 2010
    ..resource needed to exploit an emerging animal model system that has proven utility for understanding the biological and environmental mechanisms of social behavior in humans related to alcoholism, autism, parental care, and pair-bonding.
  57. Alcohol abuse and Endoplasmic Reticulum dysfunction in exocrine pancreas
    Aurelia Lugea; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Alcoholism remains the most common form of drug abuse in the United States...
  58. Intestinal Vitamin B2 Absorption: Molecular/Cellular Aspects and Effects of Alcoh
    Hamid M Said; Fiscal Year: 2013
    ..Its deficiency, which occurs in a variety of conditions like chronic alcoholism, leads to serious clinical abnormalities that include degenerative changes in the nervous system, anemia, growth ..
  59. Alcohol and Development of the Prefrontal Cortex
    LEON GARLAND COLEMAN; Fiscal Year: 2011
    ..Human alcohol abuse during adolescence and young adulthood is associated with an increased risk of alcoholism in adulthood...
  60. C/EBP beta Peptides for the Treatment of Hepatic Fibrosis
    Mario Chojkier; Fiscal Year: 2010
    ..to the USA is substantial, as it is associated with Hepatitis B and C, fatty liver of obesity and diabetes and alcoholism. Additional knowledge gained by this work will facilitate the development of medication for the treatment of ..
  61. Epigenetics underlies long-term risk of relapse during abstinence
    Kristine M Wiren; Fiscal Year: 2013
    ..Both genetic and environmental contributions have crucial roles in the development of a complex disease such as alcoholism. Unfortunately, little progress has been made in identifying the underlying molecular mechanisms altered during ..
  62. Neuroimaging in the Oklahoma Family Health Patterns Project
    William R Lovallo; Fiscal Year: 2013
    ..Our goal is to develop a better understanding of central nervous system characteristics of persons at risk for alcoholism. Despite a large clinical literature on alcoholism, far less is known about the preclinical characteristics of ..
  63. Treatment Study Using Depot Naltrexone(1/6)Philadelphia Coord/Data Mgmt Site
    CHARLES P O'BRIEN; Fiscal Year: 2013
    ..Recently a depot formulation with a one month duration has received FDA approval for the treatment of alcoholism. The purpose of this study is to determine whether a monthly injection of naltrexone is practical and useful in ..
  64. GENETICS OF ALCOHOLISM IN AMERICAN INDIANS
    Richard Deitrich; Fiscal Year: 1993
    There is increasing evidence that heredity plays a role in the development of alcoholism. The proposed research will examine some of the genetic antecedents of alcoholism in the American Indian population...
  65. A Forty-Year Followup of Men at High Risk for Alcoholism
    ELIZABETH PENICK; Fiscal Year: 2004
    In January, 2001 the forty-year followup phase of the U.S.-Danish Longitudinal Study of Alcoholism was initiated with funds provided by the government of Denmark. No funds were available to support the U.S...
  66. Eliciting protective mechanisms against alcoholism
    Emanuel Rubin; Fiscal Year: 2010
    b>Alcoholism is responsible for one third of preventible loss of life in the United States. About 50-60% of the predisposition to develop alcoholism is genetically determined, and both permissive and protective genes have been identified...
  67. CBT Treatment of Panic Disorder in Comorbid Alcoholics
    MATT KUSHNER; Fiscal Year: 2003
    ..that panic disorder can contribute to risk for a new onset of alcohol disorder and to risk for relapse following alcoholism treatment...
  68. M-CPP PET Scanning of Alcoholism:Effects of Sertraline
    Monte Buchsbaum; Fiscal Year: 2006
    ..A significant body of preclinical and clinical work demonstrates the involvement of the serotonin system in alcoholism. Recent publication of two successful clinical trials of serotonin medications holds significant promise for the ..
  69. Dopamine, prediction error, and human alcohol consumption
    KARMEN YODER; Fiscal Year: 2009
    b>Alcoholism is a serious disorder that is extremely difficult to treat. Understanding the neurochemistry of alcoholism will ultimately result in more effective treatment strategies...
  70. NEUROPHYSIOLOGY IN CHILDREN AT HIGH RISK FOR ALCOHOLISM
    Bernice Porjesz; Fiscal Year: 2010
    ..sigmficantly lower in alcoholics, but also in young offspring of alcoholics at high risk (HR) for developing alcoholism These observations suggested that reduced amplitudes of the P3 component in HR individuals might antecede the ..
  71. JUSTICE SYSTEM REFERRALS AND ALCOHOLISM TREATMENT IMPACT
    Richard Speiglman; Fiscal Year: 1991
    ..examines the impact of a major social change currently occurring in the United States, publicly supported alcoholism treatment services, namely the marked ascendancy and growth of coercive referral into treatment by a variety of ..
  72. In vitro screening of novel therapeutic agents for the treatment of alcohol abuse
    S John Mihic; Fiscal Year: 2010
    ..It would be highly beneficial for the treatment of alcoholism if these positively reinforcing effects of alcohol could be antagonized by chemical means and if novel anti-..
  73. CONTROLS FOR ASSOCIATION STUDIES OF ALCOHOLISM
    Kenneth Kidd; Fiscal Year: 2009
    b>Alcoholism is a significant public health problem because of its prevalence and the high morbidity to patients and high impact on their relatives. The alcohol dehydrogenase (ADH) cluster of genes and the aldehydedehydrogenase 2 locus...
  74. Mechanism of Alcohol/Alcoholism-induced Liver Neoplasia
    CHRISTIAN MAXIMILLIAN SCHMIDT; Fiscal Year: 2010
    ..Alcohol is an etiologic factor for HCC. No animal model to date has demonstrated that alcohol/alcoholism induces HCC in the absence of other HCC risk factors...