substance related disorders

Summary

Summary: Disorders related to substance abuse, the side effects of a medication, toxin exposure, and ALCOHOL-RELATED DISORDERS.

Top Publications

  1. ncbi Neural mechanisms of addiction: the role of reward-related learning and memory
    Steven E Hyman
    Office of the Provost, Harvard University, Cambridge, Massachusetts 02138, USA
    Annu Rev Neurosci 29:565-98. 2006
  2. pmc Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex
    Rita Z Goldstein
    Medical Research, Brookhaven National Laboratory, Bldg 490, 30 Bell Avenue, Upton, NY 11973, USA
    Am J Psychiatry 159:1642-52. 2002
  3. ncbi Prevalence and co-occurrence of substance use disorders and independent mood and anxiety disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions
    Bridget F Grant
    Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892 9304, USA
    Arch Gen Psychiatry 61:807-16. 2004
  4. ncbi Prevalence, correlates, disability, and comorbidity of DSM-IV alcohol abuse and dependence in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions
    Deborah S Hasin
    Mailman School of Public Health, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Arch Gen Psychiatry 64:830-42. 2007
  5. ncbi Drug dependence, a chronic medical illness: implications for treatment, insurance, and outcomes evaluation
    A T McLellan
    The Treatment Research Institute, 150 S Independence Mall W, Suite 600, Philadelphia, PA 19106 3475, USA
    JAMA 284:1689-95. 2000
  6. ncbi Drugs of abuse and stress trigger a common synaptic adaptation in dopamine neurons
    Daniel Saal
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Neuron 37:577-82. 2003
  7. ncbi Global epidemiology of areca nut usage
    P C Gupta
    Tata Institute of Fundamental Research, India
    Addict Biol 7:77-83. 2002
  8. ncbi Prevalence, correlates, disability, and comorbidity of DSM-IV drug abuse and dependence in the United States: results from the national epidemiologic survey on alcohol and related conditions
    Wilson M Compton
    Division of Epidemiology, Services, and Prevention Research, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 9304, USA
    Arch Gen Psychiatry 64:566-76. 2007
  9. ncbi Evaluation of the Drug Use Disorders Identification Test (DUDIT) in criminal justice and detoxification settings and in a Swedish population sample
    Anne H Berman
    Center for Health Equity Studies, Stockholm University Karolinska Institutet, Department of Psychology, Stockholm University, Stockholm, Sweden
    Eur Addict Res 11:22-31. 2005
  10. ncbi Global burden of disease from alcohol, illicit drugs and tobacco
    Jurgen Rehm
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Drug Alcohol Rev 25:503-13. 2006

Detail Information

Publications358 found, 100 shown here

  1. ncbi Neural mechanisms of addiction: the role of reward-related learning and memory
    Steven E Hyman
    Office of the Provost, Harvard University, Cambridge, Massachusetts 02138, USA
    Annu Rev Neurosci 29:565-98. 2006
    ..Here we review progress in identifying candidate mechanisms of addiction...
  2. pmc Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex
    Rita Z Goldstein
    Medical Research, Brookhaven National Laboratory, Bldg 490, 30 Bell Avenue, Upton, NY 11973, USA
    Am J Psychiatry 159:1642-52. 2002
    ..Studies of the neurobiological processes underlying drug addiction primarily have focused on limbic subcortical structures. Here the authors evaluated the role of frontal cortical structures in drug addiction...
  3. ncbi Prevalence and co-occurrence of substance use disorders and independent mood and anxiety disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions
    Bridget F Grant
    Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892 9304, USA
    Arch Gen Psychiatry 61:807-16. 2004
    ..Uncertainties exist about the prevalence and comorbidity of substance use disorders and independent mood and anxiety disorders...
  4. ncbi Prevalence, correlates, disability, and comorbidity of DSM-IV alcohol abuse and dependence in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions
    Deborah S Hasin
    Mailman School of Public Health, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Arch Gen Psychiatry 64:830-42. 2007
    ..Epidemiologic information is important to inform etiological research and service delivery planning. However, current information on the epidemiology of alcohol use disorders in the United States is lacking...
  5. ncbi Drug dependence, a chronic medical illness: implications for treatment, insurance, and outcomes evaluation
    A T McLellan
    The Treatment Research Institute, 150 S Independence Mall W, Suite 600, Philadelphia, PA 19106 3475, USA
    JAMA 284:1689-95. 2000
    ..Drug dependence should be insured, treated, and evaluated like other chronic illnesses. JAMA. 2000;284:1689-1695...
  6. ncbi Drugs of abuse and stress trigger a common synaptic adaptation in dopamine neurons
    Daniel Saal
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Neuron 37:577-82. 2003
    ....
  7. ncbi Global epidemiology of areca nut usage
    P C Gupta
    Tata Institute of Fundamental Research, India
    Addict Biol 7:77-83. 2002
    ..Some interesting trends on chewing patterns have emerged from recent data, suggesting a decline in the habit in some countries such as Thailand while the prevalence of areca nut use is rising in India and Taiwan...
  8. ncbi Prevalence, correlates, disability, and comorbidity of DSM-IV drug abuse and dependence in the United States: results from the national epidemiologic survey on alcohol and related conditions
    Wilson M Compton
    Division of Epidemiology, Services, and Prevention Research, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 9304, USA
    Arch Gen Psychiatry 64:566-76. 2007
    ..Current and comprehensive information on the epidemiology of DSM-IV 12-month and lifetime drug use disorders in the United States has not been available...
  9. ncbi Evaluation of the Drug Use Disorders Identification Test (DUDIT) in criminal justice and detoxification settings and in a Swedish population sample
    Anne H Berman
    Center for Health Equity Studies, Stockholm University Karolinska Institutet, Department of Psychology, Stockholm University, Stockholm, Sweden
    Eur Addict Res 11:22-31. 2005
    ..1% scored positive on the DUDIT; T-score values are suggested. The DUDIT screens effectively for drug-related problems in clinically selected groups and may prove useful in the context of public health surveys...
  10. ncbi Global burden of disease from alcohol, illicit drugs and tobacco
    Jurgen Rehm
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Drug Alcohol Rev 25:503-13. 2006
    ..The burden of disease attributable to the use of legal substances clearly outweighed the use of illegal drugs. A large part of the substance-attributable burden would be avoidable if known effective interventions were implemented...
  11. pmc Prevalence and correlates of HIV infection among female sex workers in 2 Mexico-US border cities
    Thomas L Patterson
    University of California, San Diego, La Jolla, CA 92093 0680, USA
    J Infect Dis 197:728-32. 2008
    ..We examined human immunodeficiency virus (HIV) prevalence and correlates among female sex workers (FSWs) in Tijuana and Ciudad Juarez, 2 large cities on the Mexico-US border...
  12. ncbi Is there a common molecular pathway for addiction?
    Eric J Nestler
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390 9070, USA
    Nat Neurosci 8:1445-9. 2005
    ..A major goal for future research is to determine whether such common underpinnings of addiction can be exploited for the development of more effective treatments for a wide range of addictive disorders...
  13. ncbi Non-medical use of prescription stimulants among US college students: prevalence and correlates from a national survey
    Sean Esteban McCabe
    University of Michigan, Substance Abuse Research Center, Ann Arbor, MI 48105, USA
    Addiction 100:96-106. 2005
    ..To examine the prevalence rates and correlates of non-medical use of prescription stimulants (Ritalin, Dexedrine or Adderall) among US college students in terms of student and college characteristics...
  14. ncbi The neural basis of addiction: a pathology of motivation and choice
    Peter W Kalivas
    Department of Neurosciences, Medical University of South Carolina, 173 Ashley Ave, BSB 403, Charleston, SC 29425, USA
    Am J Psychiatry 162:1403-13. 2005
    ....
  15. ncbi Addiction: a disease of learning and memory
    Steven E Hyman
    Department of Neurobiology, Harvard Medical School, Boston, MA, USA
    Am J Psychiatry 162:1414-22. 2005
    ..The author summarizes the converging evidence in this area and highlights key questions that remain...
  16. ncbi Familial transmission of substance use disorders
    K R Merikangas
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Conn 06510, USA
    Arch Gen Psychiatry 55:973-9. 1998
    ..To perform a controlled family study of probands with several different predominant drugs of abuse, including opioids, cocaine, cannabis, and/or alcohol...
  17. ncbi Drug addiction: the neurobiology of behaviour gone awry
    Nora D Volkow
    National Institute on Drug Abuse NIH, Bethesda, MD 20892, USA
    Nat Rev Neurosci 5:963-70. 2004
    ..This, combined with new knowledge of how environmental, genetic and developmental factors contribute to addiction, should bring about changes in our approach to the prevention and treatment of addiction...
  18. ncbi Impulsivity resulting from frontostriatal dysfunction in drug abuse: implications for the control of behavior by reward-related stimuli
    J D Jentsch
    Section of Neurobiology, Yale University School of Medicine, 333 Cedar Street, P O Box 208001, New Haven, CT 06520 8001, USA
    Psychopharmacology (Berl) 146:373-90. 1999
    ..The evidence for cognitive impulsivity in drug abuse associated with dysfunction of the frontostriatal system will be discussed, and an integrative hypothesis for compulsive reward-seeking in drug abuse will be presented...
  19. pmc Developmental neurocircuitry of motivation in adolescence: a critical period of addiction vulnerability
    R Andrew Chambers
    Connecticut Mental Health Center, the Problem Grambling Clinic, Yale University School of Medicine, New Haven, CT 06508, USA
    Am J Psychiatry 160:1041-52. 2003
    ..The authors describe basic and clinical data supporting adolescent neurodevelopment as a biologically critical period of greater vulnerability for experimentation with substances and acquisition of substance use disorders...
  20. pmc Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts 02115, USA
    Arch Gen Psychiatry 62:617-27. 2005
    ..Little is known about the general population prevalence or severity of DSM-IV mental disorders...
  21. pmc The addicted human brain: insights from imaging studies
    Nora D Volkow
    Department of Medicine, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Clin Invest 111:1444-51. 2003
  22. pmc Non-injection drug use and Hepatitis C Virus: a systematic review
    Roberta Scheinmann
    Center for Drug Use and HIV Research, National Development and Research Institutes NDRI, 71 West 23rd Street, 8th Floor, New York, NY 10010, United States
    Drug Alcohol Depend 89:1-12. 2007
    ..These studies point to a real problem of HCV in NIDU populations, but the causal pathway to infection remains unclear...
  23. pmc Review. Neurobiological mechanisms for opponent motivational processes in addiction
    George F Koob
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Philos Trans R Soc Lond B Biol Sci 363:3113-23. 2008
    ....
  24. ncbi Neurobiological mechanisms in the transition from drug use to drug dependence
    George F Koob
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neurosci Biobehav Rev 27:739-49. 2004
    ....
  25. ncbi Conditioned place preference: what does it add to our preclinical understanding of drug reward?
    M T Bardo
    Department of Psychology, University of Kentucky, Lexington, KY 40506, USA
    Psychopharmacology (Berl) 153:31-43. 2000
    ..However, a number of controversial issues have surrounded the use of this experimental protocol...
  26. pmc Screening for drug abuse among medical and nonmedical users of prescription drugs in a probability sample of college students
    Sean Esteban McCabe
    Substance Abuse Research Center, University of Michigan, 2025 Traverwood Dr, Ste C, Ann Arbor, MI 48105 2194, USA
    Arch Pediatr Adolesc Med 162:225-31. 2008
    ....
  27. ncbi The health status of young adults in the United States
    M Jane Park
    Department of Pediatrics, Division of Adolescent Medicine, University of California, San Francisco, San Francisco, California 94143 0503, USA
    J Adolesc Health 39:305-17. 2006
    ....
  28. ncbi The relative contribution of outcome domains in the total economic benefit of addiction interventions: a review of first findings
    Kathryn E McCollister
    Health Services Research Center and Department of Epidemiology and Public Health D93, University of Miami, Miami, FL 33136, USA
    Addiction 98:1647-59. 2003
    ..This paper provides a focused summary of the relative contribution of addiction intervention outcomes to total economic benefit, based upon a compilation of published economic studies from the United States...
  29. ncbi Compounded brain volume deficits in schizophrenia-alcoholism comorbidity
    Daniel H Mathalon
    Department of Psychiatry, Yale University School of Medicine Veterans Affairs Connecticut Healthcare System, West Haven 06516, USA
    Arch Gen Psychiatry 60:245-52. 2003
    ..Schizophrenia and alcoholism are characterized by brain volume abnormalities. Despite the frequent comorbidity of these conditions, the potentially compounded effects of comorbidity on brain structure have seldom been rigorously assessed...
  30. pmc Screening, brief interventions, referral to treatment (SBIRT) for illicit drug and alcohol use at multiple healthcare sites: comparison at intake and 6 months later
    Bertha K Madras
    Harvard Medical School NEPRC, 1 Pine Hill Drive, Southborough, MA 01772, USA
    Drug Alcohol Depend 99:280-95. 2009
    ..We compared illicit drug use at intake and 6 months after drug screening and interventions were administered...
  31. ncbi The impact of substance use disorders on clinical outcome in 643 patients with first-episode psychosis
    M Lambert
    Centre for Psychosocial Medicine, Department of Psychiatry and Psychotherapy, Psychosis Early Detection and Intervention Centre PEDIC, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Acta Psychiatr Scand 112:141-8. 2005
    ..The main aim of the present study was to assess the impact of baseline SUD and course of SUD on remission of positive symptoms...
  32. ncbi Evidence that intermittent, excessive sugar intake causes endogenous opioid dependence
    Carlo Colantuoni
    Department of Psychology, Princeton University, New Jersey 08544, USA
    Obes Res 10:478-88. 2002
    ..Because palatable food stimulates neural systems that are implicated in drug addiction, it was hypothesized that intermittent, excessive sugar intake might create dependency, as indicated by withdrawal signs...
  33. ncbi The intricate link between violence and mental disorder: results from the National Epidemiologic Survey on Alcohol and Related Conditions
    Eric B Elbogen
    Forensic Psychiatry Program and Clinic, Department of Psychiatry, University of North Carolina Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA
    Arch Gen Psychiatry 66:152-61. 2009
    ..The relationship between mental illness and violence has a significant effect on mental health policy, clinical practice, and public opinion about the dangerousness of people with psychiatric disorders...
  34. pmc Reliability of DSM-IV diagnostic criteria using the semi-structured assessment for drug dependence and alcoholism (SSADDA)
    Amira Pierucci-Lagha
    Alcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, United States
    Drug Alcohol Depend 91:85-90. 2007
    ..This study examines the reliability of individual DSM-IV criteria for lifetime substance dependence diagnoses and the impact of those criteria on diagnostic reliability...
  35. ncbi Nonmedical use of prescription stimulants in the United States
    Larry A Kroutil
    RTI International, 3040 Cornwallis Road, Research Triangle Park, NC 27709, USA
    Drug Alcohol Depend 84:135-43. 2006
    ..This study estimated prevalences and correlates of stimulant diversion in the United States and examined relationships between diversion and measures of abuse or dependence...
  36. ncbi Exploration of adverse psychological symptoms in Yemeni khat users by the Symptoms Checklist-90 (SCL-90)
    Nabil Numan
    National Institute of Psychiatry and Neurology, Semmelweis University, Budapest, Hungary
    Addiction 99:61-5. 2004
    ..The present study was aimed at assessing associations between psychological symptoms and khat use in the Yemeni population...
  37. pmc Medical use, illicit use, and diversion of abusable prescription drugs
    Sean Esteban McCabe
    Substance Abuse Research Center, University of Michigan, Ann Arbor 48105 2194, USA
    J Am Coll Health 54:269-78. 2006
    ..The authors provide evidence that prescription drug abuse is a problem among college students...
  38. ncbi Addiction treatment services and co-occurring disorders: Prevalence estimates, treatment practices, and barriers
    Mark P McGovern
    Department of Psychiatry, New Hampshire Dartmouth Psychiatric Research Center, Dartmouth Medical School, Lebanon, NH, USA
    J Subst Abuse Treat 31:267-75. 2006
    ..This objective information is critical for systems intending to enhance services to persons with co-occurring disorders...
  39. ncbi Synaptic plasticity and addiction
    Julie A Kauer
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, Rhode Island 02912, USA
    Nat Rev Neurosci 8:844-58. 2007
    ..Reversing or preventing these drug-induced synaptic modifications may prove beneficial in the treatment of one of society's most intractable health problems...
  40. ncbi Assessing the abuse potential of methylphenidate in nonhuman and human subjects: a review
    S H Kollins
    Department of Psychiatry, Duke University Medical Center, Box 3431, Durham, NC 27710, USA
    Pharmacol Biochem Behav 68:611-27. 2001
    ....
  41. pmc Risk of psychiatric disorders among individuals reporting same-sex sexual partners in the National Comorbidity Survey
    S E Gilman
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Ave, Boston, MA 02115, USA
    Am J Public Health 91:933-9. 2001
    ..Further research is needed to replicate and explore the causal mechanisms underlying this association...
  42. ncbi The changing face of teenage drug abuse--the trend toward prescription drugs
    Richard A Friedman
    Psychopharmacology Clinic at Weill Cornell Medical College, New York, USA
    N Engl J Med 354:1448-50. 2006
  43. ncbi Experiences of anabolic steroid use: in-depth interviews with men and women body builders
    Sarah Grogan
    Department of Psychiatry, Staffordshire University, Stoke on Trent, UK
    J Health Psychol 11:845-56. 2006
    ..Social support, especially from within the body building community, was an important motivator. It is concluded that intervention programmes need the support of the body building community in order to be effective...
  44. ncbi Metabolic effects of the consumption of Areca catechu
    B J Boucher
    Department of Diabetes and Metabolic Medicine, Medical and Dental School, Queen Mary, University of London, Royal London Hospital, Whitechapel, London, UK
    Addict Biol 7:103-10. 2002
    ..The effects of chronic betel usage in man are at least as diverse as those of smoking and the habit increases the risks of ill health...
  45. ncbi HIV infection, drug use, and onset of natural menopause
    Ellie E Schoenbaum
    Department of Epidemiology and Population Health, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, New York 10467, USA
    Clin Infect Dis 41:1517-24. 2005
    ..To study the relationship of HIV infection and drug use with the onset of natural menopause...
  46. ncbi Prevalence and characteristics of clients with co-occurring disorders in outpatient substance abuse treatment
    Katherine E Watkins
    RAND, Santa Monica, California 90407 2138, USA
    Am J Drug Alcohol Abuse 30:749-64. 2004
    ..Identifying people with probable mental health disorders as they enter treatment has the potential to increase access to care among those with limited prior access...
  47. ncbi Drugs and sexual effects: role of drug type and gender
    Richard A Rawson
    UCLA Integrated Substance Abuse Programs, Los Angeles, CA 90025, USA
    J Subst Abuse Treat 22:103-8. 2002
    ..Development of a valid measure assessing the type and strength of these relationships may be beneficial for use by treatment programs in promoting abstinence from drug and alcohol use and preventing relapse...
  48. pmc Overlapping neuronal circuits in addiction and obesity: evidence of systems pathology
    Nora D Volkow
    National Institute on Drug Abuse, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA
    Philos Trans R Soc Lond B Biol Sci 363:3191-200. 2008
    ..These neuronal circuits, which are modulated by DA, interact with one another so that disruption in one circuit can be buffered by another, which highlights the need of multiprong approaches in the treatment of addiction and obesity...
  49. ncbi Schizophrenia, substance abuse, and violent crime
    Seena Fazel
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, England
    JAMA 301:2016-23. 2009
    ..Despite this uncertainty, current guidelines recommend that violence risk assessment should be conducted for all patients with schizophrenia...
  50. pmc The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk
    H Zhang
    VA Connecticut Healthcare System, West Haven Campus, West Haven, CT 06516, USA
    Mol Psychiatry 13:531-43. 2008
    ..90). Population stratification artifact was not observed in the sample. Taken together, our findings supported a positive association between OPRD1 variants and SD, and a positive haplotypic association between OPRK1 and AD in EAs...
  51. pmc Review. The neurobiology of pathological gambling and drug addiction: an overview and new findings
    Marc N Potenza
    Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, Room S 104, 34 Park Street, New Haven, CT 06519, USA
    Philos Trans R Soc Lond B Biol Sci 363:3181-9. 2008
    ..Implications for prevention and treatment strategies will be discussed...
  52. ncbi Familial transmission of substance dependence: alcohol, marijuana, cocaine, and habitual smoking: a report from the Collaborative Study on the Genetics of Alcoholism
    L J Bierut
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Gen Psychiatry 55:982-8. 1998
    ..Alcoholism and substance dependence frequently co-occur. Accordingly, we evaluated the familial transmission of alcohol, marijuana, and cocaine dependence and habitual smoking in the Collaborative Study on the Genetics of Alcoholism...
  53. ncbi Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective
    Antoine Bechara
    Institute for the Neurological Study of Emotion and Creativity, Department of Psychology, University of Southern California, Los Angeles, California 90089 2520, USA
    Nat Neurosci 8:1458-63. 2005
    ....
  54. ncbi The role of the primary care provider in preventing and treating alcohol problems in adolescents
    J R Knight
    Department of Pediatrics and Division of Addictions, Harvard Medical School, Boston, MA 02115, USA
    Ambul Pediatr 1:150-61. 2001
    ..The following article summarizes what is currently known about adolescent alcohol use and how it can be addressed in primary care settings. It provided the background for the meeting's focus on adolescent issues...
  55. ncbi Addiction is a brain disease, and it matters
    A I Leshner
    National Institute on Drug Abuse, National Institutes of Health, 5600 Fishers Lane, room 10 05, Rockville, MD 20857, USA
    Science 278:45-7. 1997
    ....
  56. ncbi Actual causes of death in the United States, 2000
    Ali H Mokdad
    Division of Adult and Community Health, Centers for Disease Control and Prevention, Atlanta, GA, USA
    JAMA 291:1238-45. 2004
    ..Modifiable behavioral risk factors are leading causes of mortality in the United States. Quantifying these will provide insight into the effects of recent trends and the implications of missed prevention opportunities...
  57. pmc Association between obesity and psychiatric disorders in the US adult population
    Gregory E Simon
    Center for Health Studies, Group Health Cooperative, Seattle, WA 98101, USA
    Arch Gen Psychiatry 63:824-30. 2006
    ..Epidemiologic data suggest an association between obesity and depression, but findings vary across studies and suggest a stronger relationship in women than men...
  58. ncbi A Norwegian psychiatric epidemiological study
    E Kringlen
    Department of Psychiatry, University of Oslo, Norway
    Am J Psychiatry 158:1091-8. 2001
    ..The rates for women are higher than those for men for all diagnostic categories, except for alcohol and drug abuse/dependence...
  59. pmc Use of mental health services for anxiety, mood, and substance disorders in 17 countries in the WHO world mental health surveys
    Philip S Wang
    Division of Services and Intervention Research, National Institute of Mental Health, Rockville, MD, USA
    Lancet 370:841-50. 2007
    ..We describe mental health care in 17 countries participating in the WHO world mental health (WMH) survey initiative and examine unmet needs for treatment...
  60. ncbi Stress and coping behaviors of substance-abusing mothers
    S J Kelley
    College of Health and Human Sciences, Georgia State University, Atlanta, USA
    J Soc Pediatr Nurs 3:103-10. 1998
    ..To examine parenting stress and coping behaviors in substance-abusing and non-substance-abusing mothers...
  61. ncbi Conduct and attentional problems in childhood and adolescence and later substance use, abuse and dependence: results of a 25-year longitudinal study
    David M Fergusson
    Christchurch Health and Development Study, Christchurch School of Medicine and Health Sciences, P O Box 4345, Christchurch, New Zealand
    Drug Alcohol Depend 88:S14-26. 2007
    ..This paper examines the linkages between conduct problems and attentional problems in middle childhood and adolescence and later substance use, abuse and dependence in young adulthood...
  62. ncbi Characteristics of effective school-based substance abuse prevention
    Denise C Gottfredson
    Department of Criminology and Criminal Justice, University of Maryland, College Park, Maryland 20742, USA
    Prev Sci 4:27-38. 2003
    ..Suggestions for future research are offered...
  63. ncbi It could be habit forming: drugs of abuse and striatal synaptic plasticity
    Gregory L Gerdeman
    Department of Pharmacology, University of Arizona Health Sciences Center, Tucson, AZ 85724, USA
    Trends Neurosci 26:184-92. 2003
    ....
  64. pmc The potential for bridging of HIV transmission in the Russian Federation: sex risk behaviors and HIV prevalence among drug users (DUs) and their non-DU sex partners
    Linda M Niccolai
    Yale School of Public Health and Center for Interdisciplinary Research on AIDS, Yale University, 60 College Street, New Haven, CT 06520, USA
    J Urban Health 86:131-43. 2009
    ..The degree to which there will be further transmission from non-DU sex partners of DUs who exhibit high levels of sex risk behaviors to other non-DU sex partners deserves further study...
  65. ncbi Posttraumatic stress disorder and the incidence of nicotine, alcohol, and other drug disorders in persons who have experienced trauma
    Naomi Breslau
    Department of Psychiatry, Henry Ford Health System, Detroit, MI 48202 3450, USA
    Arch Gen Psychiatry 60:289-94. 2003
    ..We examine whether exposure to traumatic events increases the risk for nicotine dependence or alcohol or other drug use disorders, independent of posttraumatic stress disorder (PTSD)...
  66. pmc New inroads in preventing adolescent drug use: results from a large-scale trial of project ALERT in middle schools
    Phyllis L Ellickson
    RAND, Santa Monica, CA 90407 2138, USA
    Am J Public Health 93:1830-6. 2003
    ..We evaluated the revised Project ALERT drug prevention program across a wide variety of Midwestern schools and communities...
  67. ncbi High-risk behaviors associated with early smoking: results from a 5-year follow-up
    P L Ellickson
    RAND, Santa Monica, California 90407-2138, USA
    J Adolesc Health 28:465-73. 2001
    ..Results suggest that substance use programs that target multiple problems in addition to smoking may be most effective for these high-risk adolescents...
  68. ncbi Areca nut-abuse liability, dependence and public health
    A Winstock
    Institute of Psychiatry, National Addiction Centre, De Cresigny Park, London, UK
    Addict Biol 7:133-8. 2002
    ..In this paper I will explore its use and properties with respect to its abuse and dependence liability and consider the associated implications for public health...
  69. ncbi Neurological aspects of areca and betel chewing
    Nai Shin Chu
    Department of Neurology, Chang Gung University College of Medicine, Taipei, Taiwan
    Addict Biol 7:111-4. 2002
    ..Although arecoline has been thought to be responsible for several effects of betel quid chewing, the present data suggest a role also played by sympathetic activation...
  70. ncbi Violence against substance-abusing South African sex workers: intersection with culture and HIV risk
    W M Wechsberg
    RTI International, Research Triangle Park, NC 27709, USA
    AIDS Care 17:S55-64. 2005
    ..Results support the critical need for targeted, comprehensive interventions that address substance abuse, sexual risk, and violence as interrelated phenomena...
  71. ncbi Social capital and substance use among Swedish adolescents--an explorative study
    Petter Lundborg
    Lund University Centre for Health Economics, P O Box 705, SE 220 07 Lund, Sweden
    Soc Sci Med 61:1151-8. 2005
    ....
  72. ncbi The roles of cannabinoid and dopamine receptor systems in neural emotional learning circuits: implications for schizophrenia and addiction
    S R Laviolette
    Department of Neuroscience, The University of Pittsburgh, Pittsburgh, 458 Crawford Hall, Pennsylvania 15260, USA
    Cell Mol Life Sci 63:1597-613. 2006
    ....
  73. ncbi Medical comorbidity in women and men with bipolar disorders: a population-based controlled study
    Caroline P Carney
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46250, USA
    Psychosom Med 68:684-91. 2006
    ..This study examines chronic medical comorbidity using validated methodology in persons with bipolar disorder...
  74. ncbi The relationship between early age of onset of initial substance use and engaging in multiple health risk behaviors among young adolescents
    R H DuRant
    Department of Pediatrics, Brenner Children s Hospital and the Brenner Center for Child and Adolescent Health, Wake Forest University, School of Medicine, Winston Salem, NC 25157 1081, USA
    Arch Pediatr Adolesc Med 153:286-91. 1999
    ..It is unknown whether these relationships begin during early adolescence...
  75. ncbi Risk factors for community-associated methicillin-resistant Staphylococcus aureus skin infections among HIV-positive men who have sex with men
    Nolan E Lee
    Epidemic Intelligence Service, Epidemiology Program Office, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Clin Infect Dis 40:1529-34. 2005
    ..We performed a matched case-control study of 35 case patients and 76 control subjects. CA-MRSA skin infections were associated with high-risk sex and drug-using behaviors and with environmental exposures but not with immune status...
  76. ncbi Implementing dual diagnosis services for clients with severe mental illness
    R E Drake
    New Hampshire Dartmouth Psychiatric Research Center, Lebanon, New Hamphire 03766, USA
    Psychiatr Serv 52:469-76. 2001
    ....
  77. ncbi The social epidemiology of substance use
    Sandro Galea
    Center for Urban Epidemiologic Studies, New York Academy of Medicine, New York, NY 10029, USA
    Epidemiol Rev 26:36-52. 2004
  78. pmc Prevalence of HIV, hepatitis B, and hepatitis C in people with severe mental illness
    S D Rosenberg
    Department of Psychiatry, Dartmouth Medical School, New Hampshire Dartmouth Psychiatric Research Center, Lebanon, NH, USA
    Am J Public Health 91:31-7. 2001
    ..This study assessed seroprevalence rates of HIV, hepatitis B virus (HBV), and hepatitis C virus (HCV) among individuals with severe mental illness...
  79. pmc A somatic marker theory of addiction
    Antonio Verdejo-Garcia
    Department of Clinical Psychology and Institute of Neuroscience, Universidad de Granada, Spain
    Neuropharmacology 56:48-62. 2009
    ....
  80. ncbi Correlates of partner violence among female street-based sex workers: substance abuse, history of childhood abuse, and HIV risks
    N El-Bassel
    Social Intervention Group, Columbia University, New York, NY 10025, USA
    AIDS Patient Care STDS 15:41-51. 2001
    ....
  81. ncbi Prevalence and development of psychiatric disorders in childhood and adolescence
    E Jane Costello
    Department of Psychiatry and Behavioral Sciences, Duke University Medical School, Durham, NC 27710, USA
    Arch Gen Psychiatry 60:837-44. 2003
    ..This longitudinal community study assessed the prevalence and development of psychiatric disorders from age 9 through 16 years and examined homotypic and heterotypic continuity...
  82. ncbi Poor response inhibition as a predictor of problem drinking and illicit drug use in adolescents at risk for alcoholism and other substance use disorders
    Joel T Nigg
    Department of Psychology, Michigan State University, East Lansing, MI 48824 116, USA
    J Am Acad Child Adolesc Psychiatry 45:468-75. 2006
    ..To evaluate the predictive power of executive functions, in particular, response inhibition, in relation to alcohol-related problems and illicit drug use in adolescence...
  83. ncbi Suicide in developing countries (2): risk factors
    Lakshmi Vijayakumar
    SNEHA and VHS, Chennai, India
    Crisis 26:112-9. 2005
    ....
  84. pmc A meta-analysis of retention in methadone maintenance by dose and dosing strategy
    Yan Ping Bao
    National Institute on Drug Dependence, Peking University, Beijing, China
    Am J Drug Alcohol Abuse 35:28-33. 2009
    ..To estimate, via meta-analysis, the influence of different methadone dose ranges and dosing strategies on retention rates in methadone maintenance treatment (MMT)...
  85. ncbi CNR1 variation modulates risk for drug and alcohol dependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, 950 Campbell Avenue, New Haven, CT 06516, USA
    Biol Psychiatry 62:616-26. 2007
    ..Following initial reports of association of CNR1 with SD, we studied multiple markers at this locus in a large case-control sample...
  86. ncbi Association of dopamine transporter reduction with psychomotor impairment in methamphetamine abusers
    N D Volkow
    Department of Psychiatry, State University of New York at Stony Brook, USA
    Am J Psychiatry 158:377-82. 2001
    ..The authors evaluated if similar changes occur in humans and assessed if they were functionally significant...
  87. ncbi Sharing of noninjection drug-use implements as a risk factor for hepatitis C
    Stephanie Tortu
    Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA
    Subst Use Misuse 39:211-24. 2004
    ..8, 1 d.f., p < 0.01). These findings, if supported by future research, indicate a need to reassess policies regarding HCV infection...
  88. ncbi Opioids block long-term potentiation of inhibitory synapses
    Fereshteh S Nugent
    Brown University, Department of Molecular Pharmacology, Physiology and Biotechnology, Providence, Rhode Island 02912, USA
    Nature 446:1086-90. 2007
    ..These neuroadaptations to opioid drugs might contribute to early stages of addiction, and may potentially be exploited therapeutically using drugs targeting GABA(A) receptors...
  89. ncbi Dimensions of religiosity and their relationship to lifetime psychiatric and substance use disorders
    Kenneth S Kendler
    Virginia Institute for Psychiatry and Behavioral Genetics and Department of Psychiatry and Human Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0126, USA
    Am J Psychiatry 160:496-503. 2003
    ..This study used data from a general population sample to clarify the dimensions of religiosity and the relationships of these dimensions to risk for lifetime psychiatric and substance use disorders...
  90. ncbi Dopamine in drug abuse and addiction: results from imaging studies and treatment implications
    N D Volkow
    National Institute on Drug Abuse, Bethesda, MD 20892, USA
    Mol Psychiatry 9:557-69. 2004
    ....
  91. pmc Don't wanna go through that madness no more: quality of life satisfaction as predictor of sustained remission from illicit drug misuse
    Alexandre B Laudet
    Center for the Study of Addictions and Recovery C STAR, National Development and Research Institutes, Inc, New York, New York 10010, USA
    Subst Use Misuse 44:227-52. 2009
    ..Implications are noted, especially the need for the addiction field to continue moving away from the pathology-focused model of care toward a broader model that embraces multiple dimensions of positive health as a key outcome...
  92. ncbi Protecting adolescents from harm. Findings from the National Longitudinal Study on Adolescent Health
    M D Resnick
    Adolescent Health Program, University of Minnesota, Minneapolis 55455, USA
    JAMA 278:823-32. 1997
    ..The main threats to adolescents' health are the risk behaviors they choose. How their social context shapes their behaviors is poorly understood...
  93. ncbi Substance use disorders in patients with posttraumatic stress disorder: a review of the literature
    L K Jacobsen
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Am J Psychiatry 158:1184-90. 2001
    ..This article reviews studies pertaining to the epidemiology, clinical phenomenology, and pathophysiology of comorbid PTSD and substance use disorders...
  94. ncbi Comorbidity between DSM-IV alcohol and specific drug use disorders in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions
    Frederick S Stinson
    Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 9304, USA
    Drug Alcohol Depend 80:105-16. 2005
    ....
  95. ncbi The long-term natural history of the weekly symptomatic status of bipolar I disorder
    Lewis L Judd
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093 0603, USA
    Arch Gen Psychiatry 59:530-7. 2002
    ..To our knowledge, this is the first prospective natural history study of weekly symptomatic status of patients with bipolar I disorder (BP-I) during long-term follow-up...
  96. ncbi What works in prevention. Principles of effective prevention programs
    Maury Nation
    Department of Human and Organizational Development, Vanderbilt University, Peabody College, 90, Nashville, TN 37203, USA
    Am Psychol 58:449-56. 2003
    ..This synthesis can inform the planning and implementation of problem-specific prevention interventions, provide a rationale for multi-problem prevention programs, and serve as a basis for further research...
  97. pmc Haplotypic variants in DRD2, ANKK1, TTC12, and NCAM1 are associated with comorbid alcohol and drug dependence
    Bao zhu Yang
    Department of Psychiatry, Division of Human Genetics, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Alcohol Clin Exp Res 32:2117-27. 2008
    ..Because comorbid AD with DD (AD+DD) is common, we hypothesized that heterogeneity of the SD diagnoses studied might have contributed to the inconsistency of prior results...
  98. ncbi Universal precautions in pain medicine: a rational approach to the treatment of chronic pain
    Douglas L Gourlay
    The Wasser Pain Management Center, Mount Sinai Hospital, Toronto, Ontario, Canada
    Pain Med 6:107-12. 2005
    ..By taking a thorough and respectful approach to patient assessment and management within chronic pain treatment, stigma can be reduced, patient care improved, and overall risk contained...
  99. ncbi The many faces of CREB
    William A Carlezon
    Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont MA 02478, USA
    Trends Neurosci 28:436-45. 2005
    ....
  100. ncbi The relationship of psychiatric comorbidity to treatment outcomes in methadone maintained patients
    J S Cacciola
    The University of Pennsylvania Medical School Philadelphia Veterans Affairs Medical Center, Center for the Studies of Addiction, Building 3, University and Civic Center Boulevard, Philadelphia, PA 19104 6021, USA
    Drug Alcohol Depend 61:271-80. 2001
    ..Admission and month 7 substance use were, for the most part, not related to psychiatric comorbidity, although there was a trend indicating more treatment attrition for participants with personality disorders...
  101. ncbi Intranasal transmission of hepatitis C virus: virological and clinical evidence
    Sagiv Aaron
    Molecular Virology Division, St Luke s Roosevelt Institute for Health Sciences Columbia University
    Clin Infect Dis 47:931-4. 2008
    ....

Research Grants63

  1. Naltrexone for Bipolar Disorder and Alcohol Dependence
    E Sherwood Brown; Fiscal Year: 2006
    ..Alcohol use is the primary outcome, and alcohol craving is the secondary outcome. Manic and depressive symptom severity and the relationship between changes in alcohol use and changes in mood will be expIored. ..
  2. Development of a5* nAChR positive allosteric modulators for tobacco dependence
    JON MARTIN LINDSTROM; Fiscal Year: 2013
    ..provided by applicant): This application is in response to RFA-DA-10-018, Medications Development for Substance Related Disorders (R01)...
  3. Improving the efficacy of anti-nicotine immunotherapy
    Alexey G Mukhin; Fiscal Year: 2010
    ..Nicotine and Tobacco Research" and addresses the specific area, "Vaccines/Immunotherapies for Substance Related Disorders." Nicotine dependence, maintained by tobacco smoking, is a chronic relapsing disorder that constitutes ..
  4. Citicoline Treatment of Methamphetamine Dependence
    PERRY FRANKLIN RENSHAW; Fiscal Year: 2010
    ..of MA dependence as a response to RFA-DA-09-005, "Pilot Clinical Trials of Pharmacotherapies for Substance Related Disorders". Citicoline has demonstrated efficacy in treating a number of central nervous system disorders...
  5. Studies on the the mechanism of OPRM1 biased agonism and in vivo consequences: Di
    Ping Yee Law; Fiscal Year: 2013
    ....
  6. Transdermal Naltrexone for Opiate Addiction and Alcoholism
    Audra L Stinchcomb; Fiscal Year: 2012
    ....
  7. St. John's wort for Drug Abuse Treatment During Pregnancy
    C LINDSAY LINDSAY DEVANE; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Substance related disorders in pregnancy constitute a public health problem with increased risk of maternal and neonatal morbidity and mortality...
  8. Dopaminergic genetic contributions to obesity in kidney transplant recipients
    Ansley Stanfill; Fiscal Year: 2013
    ....
  9. Epidemiology and modeling of the population dynamics of influenza and antimicrobi
    Edward Goldstein; Fiscal Year: 2013
    ..The candidate intends to seek tenure track academic positions during years 3-5 of the K01 award. ..
  10. IND-enabling Studies and GMP Scale-up of 18-Methoxycoronaridine hydrochloride(18-
    Scott Freeman; Fiscal Year: 2013
    ..IND-enabling GLP dog toxicology studies will include: a dose finding study;7- and 28-day studies with low, intermediate and high doses to identify the NOAEL;a cocaine interaction study;and a single dose cardiovascular effects study. ..
  11. Oral transmucosal drug delivery system for naltrexone for alcohol dependence trea
    HOCK TAN; Fiscal Year: 2009
    ..In addition, the proposed technology is a platform that could be extended and developed into improved dosage forms for other substance abuse medications. ..
  12. A Six-Month, RCT of Probuphine Safety and Efficacy in Opioid Addiction
    Katherine L Beebe; Fiscal Year: 2010
    ..Infrastructure Grand Opportunities (RC2) (RFA-OD-09-004) priority area: "Small Molecule Development for Substance Related Disorders." Addiction to heroin and prescription opioids represents a worldwide health and social crisis. Over 1...
  13. Molecular Regulation of Metabotropic Glutamate Receptors in Striatal Neurons
    Qiang Wang; Fiscal Year: 2013
    ..The information obtained through this project is valuable for the development of new pharmacotherapies for mental illnesses stemming from dysfunctional glutamatergic transmission in the central nervous system. ..
  14. Saliva Analyzer for Diagnosing SRD Patient Drug Use
    Stuart Farquharson; Fiscal Year: 2012
    ....
  15. HUMAN GENETIC VARIATION IN SMOKING AND ADDICTION RISK
    Nancy L Saccone; Fiscal Year: 2013
    ..Explaining more of the genetic architecture that underlies this extremely important public health problem will inform continued efforts to prevent and control smoking and other substance addiction. ..
  16. Tools for Optimizing Prescribing, Monitoring and Education
    Bruce L Lambert; Fiscal Year: 2010
    ....
  17. Oral transmucosal drug delivery system for naltrexone
    HOCK SENG TAN; Fiscal Year: 2013
    ..Upon successful completion of this program, a SBIR Phase III follow-up program is proposed that will include filing of IND and conducting the Phase I clinical safety/proof-of-concept study. ..
  18. Cognitive Control, Working Memory and Prefrontal Cortex
    MARK D'ESPOSITO; Fiscal Year: 2013
    ..Moreover, cognitive and behavioral deficits from PFC damage are particularly challenging to treat. A greater understanding of frontal lobe function is necessary for developing effective therapeutic interventions. ..
  19. Novel Ondansetron Formulation for Combination Treatment of Psychostimulant Abuse
    Ashwin A Patkar; Fiscal Year: 2010
    ..directly addresses one of the NIDA's high priority topics, namely "Small Molecule Development for Substance Related Disorders." The stated goal of this topic is to "develop safe and effective medications for the treatment of drug ..
  20. Possible treatment of cocaine craving and relapse by memory erasure
    Gal Yadid; Fiscal Year: 2010
    ....
  21. Postmarketing Surveillance of Generic Drug Usage and Substitution Patterns
    Ilene H Zuckerman; Fiscal Year: 2013
    ..abstract_text> ..
  22. SUBSTANCE ADDICTION COLLABORATION CHANNEL(SACC)
    STANLEY R PATTON; Fiscal Year: 2012
    ....
  23. Substance Addiction Collaboration Channel (SACC)
    STANLEY R contact PATTON; Fiscal Year: 2010
    ..SACC finally delivers on the promise to provide state-of- the-art interactive training and communities. ..
  24. Substance Abuse &Treatment Gaps in Asians, Pacific Islanders &Multiple-race Ind
    LI TZY T WU; Fiscal Year: 2013
    ..This project constitutes an initial and cost-effective step to study the distributions, correlates, courses, consequences, and treatment gaps of substance problems among AAs, PIs, and MRs. ..
  25. Medications Development for the Treatment of Cannabis Related Disorders
    HEATHER MAY HAUGHEY; Fiscal Year: 2010
    ..One of NIDA's highest priorities for funding is the development of effective pharmacotherapies for substance related disorders. In response to RFA-DA-09-005, soliciting pilot clinical/human studies of interventions that ..
  26. Development of a Point-of-Care Volumetric Bar-Chart Chip for Drug Quantitation
    Ping Wang; Fiscal Year: 2013
    ..The development of the V-Chip thus marks a POC milestone and opens up the possibility of instrument-free personalized diagnosis and SUD management. ..
  27. Pathway-based analysis of addiction susceptibility genes
    Joanna M Biernacka; Fiscal Year: 2010
    ....
  28. Core Center for Translational Addiction Sciences
    Kathryn A Cunningham; Fiscal Year: 2010
    ..This P30 is responsive to NIDA's areas of interest in small molecule development for substance-related disorders, biomarkers, genetics, and vaccines and immunotherapies. ..
  29. OUTPATIENT AVERSION THERAPY FOR COCAINE ABUSE
    RALPH ELKINS; Fiscal Year: 1999
    ..Dependent variables include abstinence performance, drug usage and multiple indices of adjustment. ..
  30. DRUG USE AND HIV RISK AMONG YOUTH
    Samuel Friedman; Fiscal Year: 1999
    ..These findings can help target interventions where they are most needed and develop strategies to prevent high-risk drug use, high-risk sex, and infection with HIV. ..
  31. Prescription Drug Misuse, Abuse and Dependence
    Linda B Cottler; Fiscal Year: 2010
    ..5) Share findings with the Missouri Statewide Epidemiology Work Group, the NIDA Community Epidemiology Work Group, and the DSM-V and ICD XI Substance Related Disorders Committees.
  32. COGNITIVE AND NEURAL MECHANISMS OF SUBSTANCE ABUSE
    Antoine Bechara; Fiscal Year: 2004
    ..abstract_text> ..
  33. AIDS PREVENTION: IMIPRAMINE FOR DEPRESSED DRUG ABUSERS
    Frederick Quitkin; Fiscal Year: 1993
    ..V. drug use and high risk sexual behavior even in a small portion of methadone maintained patients, this would be an important step in diminishing the spread of HIV infection...
  34. Omega-3 Fatty Acids in Adolescents with Depression
    Vilma Gabbay; Fiscal Year: 2007
    ..disorder, attention deficit hyperactivity disorder, conduct disorder, eating disorders, and substance related disorders. Study Treatments...
  35. AIDS OUTREACH TO IV DRUG USERS, SEX PARTNER'S & RUNAWAYS
    Fen Rhodes; Fiscal Year: 1991
    ..Program effectiveness will be assessed through followup interviews and repeat HIV-antibody testing. Special pre-post evaluations will be conducted of the enhanced programs for individual subpopulations...
  36. Identification of anti-HIV agent(s) from Sophora Alkaloids
    Li Huang; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: The objective of this R21 application is to identify the active component(s) from a Chinese traditional herbal medicine "Sophora Alkaloids Tannate" that has shown potent anti-HIV activity. ..
  37. BEHAVIORAL EFFECTS OF OPIOIDS IN VOLUNTEERS
    James Zacny; Fiscal Year: 2009
    ..abstract_text> ..
  38. WORKPLACE DRUG USE PREVALENCE ESTIMATION METHODS
    ROYER COOK; Fiscal Year: 1992
    ..The self-report data and the urinalysis data will be subjected to several types of analysis...
  39. ELECTROPHYSIOLOGICAL STUDIES OF COCAINE ABSTINENCE
    RICHARD ROEMER; Fiscal Year: 1993
    ..The objective of this project is to contribute toward definition and understanding of basic human neurophysiological mechanisms associated with abstinence from substance abuse, in particular from cocaine...
  40. Trauma and Addicted Female Offenders Treatment Outcome
    SUSAN BUDNEY; Fiscal Year: 2001
    ..Outcome data will be collected through staff reports and chart documentation. The long-term goal is to use information from this study to develop an integrated treatment to serve the multiple needs of female offenders. ..
  41. WOMEN AND INFANTS TRANSMISSION STUDY (WITS III)
    Jane Pitt; Fiscal Year: 2000
    ..Studies of compliance to perinatal transmission prevention strategies in drug using nondrug using populations as well as the examination of alternate means of ascertaining hard drug usage are also being spearheaded by this site. ..
  42. CRACK DETOXIFICATION: ACUPUNCTURE TREATMENT EVALUATION
    DOUGLAS LIPTON; Fiscal Year: 1990
    ..Phase 3 involves provision of acupuncture sessions (N=100) using only a PRN schedule. The proposed project represents the first controlled study regarding outpatient acupuncture treatment for freebase cocaine/crack abusers...
  43. DISTRESS AND ALCOHOL USE IN ETHNIC MINORITIES
    Julian Thayer; Fiscal Year: 1990
    ..g., acculturation, cognitive style); and (c) Examine and elucidate differences in alcohol/drug use behavior as a function of the hierarchial distress construct and culture-specific mediating and coping mechanisms...
  44. BEHAVIORAL RISK FOR AIDS AMONG ALCOHOLICS
    Michael Windle; Fiscal Year: 1993
    ..g., Mann-Whitney U-test, Spearman's correlation, log-linear models), statistical procedures will be used to obtain measures of bivariate and multivariate association and to test for group differences...
  45. BEHAVIOR THERAPY FOR DRUG ABUSE
    Nathan Azrin; Fiscal Year: 1991
    ..Positive results would demonstrate, in a controlled treatment outcome study, a general method of treating youth drug abuse...
  46. DRUG USAGE EVALUATION & INTERVENTION IN AIDS POPULATION
    J Robinson; Fiscal Year: 1991
    ..Finally, DUE of a population of newly admitted AIDS patients would be done using the DUE program. Concurrence of the program's recommendation with that of the P & T Committee would be evaluated...
  47. ASAM PPC-2 ALGORITHM SOFTWARE DEVELOPMENT AND EVALUATION
    PAUL EARLEY; Fiscal Year: 2002
    ..based upon the American Society of Addiction Medicine Patient Placement Criteria for the Treatment of Substance Related Disorders: Second Edition (ASAM PPC-2)...
  48. SHORT COURSES ON MATHEMATICS OF BIOLOGICAL COMPLEXITY
    LOUIS GROSS; Fiscal Year: 2002
    ..g. determined by large numbers of genes or with complex pleiotropy) or because they are influenced by genetic factors that are conceptually complex (e.g. epistasis). ..
  49. The Sentinel Event Tracking Network(SETNET)System
    Dan Peterson; Fiscal Year: 2004
    ....
  50. Quantitative Analysis Methods for Complex Trait Genetics
    Nancy Saccone; Fiscal Year: 2006
    ..The candidate has designed a program of coursework and mentoring to accomplish these research and training goals and thereby achieve research independence by the end of the award period...
  51. Treatment for Black Parenting Cocaine Dependent Women
    Lauren Durant; Fiscal Year: 2007
    ..mentorships in clinical trials, technology transfer, and culturally relevant treatment approaches for substance related disorders. Related career development activities will include leadership and participation in NIDA Clinical ..
  52. MULTIMODAL TREATMENT STUDY OF CHILDREN WITH ADHD
    William Pelham; Fiscal Year: 2000
    ..Aim 4 is to examine the effect of initial treatment assignment and degree of treatment success on later academic performance, achievement, school conduct, tendency to drop out, and other adverse school outcomes. ..
  53. CONTEXT AND EFFECTIVENESS OF TWO MODELS OF SVC DELIVERY
    Christine Grella; Fiscal Year: 2002
    ..These data will provide a multilevel context in which to evaluate the implementation and effectiveness of the two models of service delivery. ..
  54. Gender Differences in a Follow-up of Opiate Users in CA
    Christine Grella; Fiscal Year: 2007
    ..The study findings have the potential to develop interventions aimed at opiate users that address the specific needs of males and females over the life course. ..
  55. Central Mechanisms of Opiate Reinforcement and Dependence
    George Koob; Fiscal Year: 2008
    ....
  56. VPBS ELECTRICAL INSTABILITY & ANTIARRHYTHMIC MEASURE
    Bernard Lown; Fiscal Year: 1980
    ....
  57. SCHOOL BASED DRUG PREVENTION PROGRAM
    Christopher Ringwalt; Fiscal Year: 2001
    ....
  58. Diffusion of Drug Prevention Curricula Nationwide
    Christopher Ringwalt; Fiscal Year: 2007
    ..abstract_text> ..