toxic hepatitis

Summary

Summary: INFLAMMATION of the LIVER due to hepatocellular toxicity, caused by drug metabolites and chemicals from the environment.

Top Publications

  1. ncbi Mechanisms of hepatotoxicity
    Hartmut Jaeschke
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Toxicol Sci 65:166-76. 2002
  2. ncbi Hepatoprotective activity of Abutilon indicum on experimental liver damage in rats
    E Porchezhian
    Dabur Research Foundation, 22, Site IV, Ghaziabad UP 201 010, India
    Phytomedicine 12:62-4. 2005
  3. ncbi Protective effect of (S)-bakuchiol from Psoralea corylifolia on rat liver injury in vitro and in vivo
    Eun Jeon Park
    Department of Pharmacy, Wonkwang University, Iksan, Jeonbuk, Republic of Korea
    Planta Med 71:508-13. 2005
  4. pmc Acetaminophen toxicity: suicidal vs. accidental
    Geeta G Gyamlani
    Department of Internal Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Crit Care 6:155-9. 2002
  5. ncbi Growth arrest-specific protein 6 deficiency impairs liver tissue repair after acute toxic hepatitis in mice
    Fouad Lafdil
    INSERM, U955, Institut Mondor de Recherche Biomedicale, 94010 Creteil, France
    J Hepatol 51:55-66. 2009
  6. ncbi Incidence of serious side effects from first-line antituberculosis drugs among patients treated for active tuberculosis
    Daphne Yee
    Respiratory Epidemiology Unit, Montreal Chest Institute, 1110 Pine Avenue West, Room 103, Montreal, PQ, H3A 1A3 Canada
    Am J Respir Crit Care Med 167:1472-7. 2003
  7. ncbi [Methimazole and propylthiouracil induced acute toxic hepatitis]
    Sonia Casallo Blanco
    Servicio de Medicina Interna, Hospital Nuestra Señora del Prado, Gregorio Corrochano 1, 45600 Talavera de la Reina, Toledo, Spain
    Gastroenterol Hepatol 30:268-70. 2007
  8. ncbi Evaluation of clinical and immunogenetic risk factors for the development of hepatotoxicity during antituberculosis treatment
    Surendra K Sharma
    Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    Am J Respir Crit Care Med 166:916-9. 2002
  9. ncbi Cytochrome P450 2E1 genotype and the susceptibility to antituberculosis drug-induced hepatitis
    Yi Shin Huang
    Division of Gastroenterology, Department of Medicine, and the Chest Department, Taipei Veterans General Hospital and National Yang Ming University School of Medicine, Taipei, Taiwan
    Hepatology 37:924-30. 2003
  10. ncbi Effect of antiretroviral therapy on liver-related mortality in patients with HIV and hepatitis C virus coinfection
    Nazifa Qurishi
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Lancet 362:1708-13. 2003

Research Grants

Detail Information

Publications226 found, 100 shown here

  1. ncbi Mechanisms of hepatotoxicity
    Hartmut Jaeschke
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Toxicol Sci 65:166-76. 2002
    ..Because of such diverse mechanisms, hepatotoxicity remains a major reason for drug withdrawal from pharmaceutical development and clinical use...
  2. ncbi Hepatoprotective activity of Abutilon indicum on experimental liver damage in rats
    E Porchezhian
    Dabur Research Foundation, 22, Site IV, Ghaziabad UP 201 010, India
    Phytomedicine 12:62-4. 2005
    ..The plant extract may interfere with free-radical formation, which may conclude in hepatoprotective action. Acute toxicity studies revealed that the LD50 value is more than the dose of 4 g/kg body wt...
  3. ncbi Protective effect of (S)-bakuchiol from Psoralea corylifolia on rat liver injury in vitro and in vivo
    Eun Jeon Park
    Department of Pharmacy, Wonkwang University, Iksan, Jeonbuk, Republic of Korea
    Planta Med 71:508-13. 2005
    ..From these results, bakuchiol has a protective effect against tBH, CCl4 or D-GalN-induced hepatotoxicity in vitro or in vivo...
  4. pmc Acetaminophen toxicity: suicidal vs. accidental
    Geeta G Gyamlani
    Department of Internal Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Crit Care 6:155-9. 2002
    ..The aim of our study was to determine the epidemiology of various types of acetaminophen poisoning and analyze their outcome compared with their admission characteristics...
  5. ncbi Growth arrest-specific protein 6 deficiency impairs liver tissue repair after acute toxic hepatitis in mice
    Fouad Lafdil
    INSERM, U955, Institut Mondor de Recherche Biomedicale, 94010 Creteil, France
    J Hepatol 51:55-66. 2009
    ..We previously reported that these sinusoidal cells secrete the growth arrest-specific protein 6 (Gas6) and express Axl, one of its receptors. Here we address the role of Gas6 in the healing process during acute liver injury...
  6. ncbi Incidence of serious side effects from first-line antituberculosis drugs among patients treated for active tuberculosis
    Daphne Yee
    Respiratory Epidemiology Unit, Montreal Chest Institute, 1110 Pine Avenue West, Room 103, Montreal, PQ, H3A 1A3 Canada
    Am J Respir Crit Care Med 167:1472-7. 2003
    ..0; 95% CI, 1.5 to 43). The incidence of pyrazinamide-induced hepatotoxicity and rash during treatment for active TB was substantially higher than with the other first-line anti-TB drugs, and higher than previously recognized...
  7. ncbi [Methimazole and propylthiouracil induced acute toxic hepatitis]
    Sonia Casallo Blanco
    Servicio de Medicina Interna, Hospital Nuestra Señora del Prado, Gregorio Corrochano 1, 45600 Talavera de la Reina, Toledo, Spain
    Gastroenterol Hepatol 30:268-70. 2007
    ..We present a clinical case of a cholestatic jaundice and acute toxic hepatitis due to methimazole and a cross-reaction with propylthiouracil. Based on this case a review is presented.
  8. ncbi Evaluation of clinical and immunogenetic risk factors for the development of hepatotoxicity during antituberculosis treatment
    Surendra K Sharma
    Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    Am J Respir Crit Care Med 166:916-9. 2002
    ..0), and presence of HLA-DQB1*0201 (OR 1.9) were independent risk factors for DIH. Our results suggest that the risk of hepatotoxicity from antituberculosis drugs is influenced by clinical and genetic factors...
  9. ncbi Cytochrome P450 2E1 genotype and the susceptibility to antituberculosis drug-induced hepatitis
    Yi Shin Huang
    Division of Gastroenterology, Department of Medicine, and the Chest Department, Taipei Veterans General Hospital and National Yang Ming University School of Medicine, Taipei, Taiwan
    Hepatology 37:924-30. 2003
    ..In conclusion, CYP 2E1 genetic polymorphism may be associated with susceptibility to antituberculosis drug-induced hepatitis...
  10. ncbi Effect of antiretroviral therapy on liver-related mortality in patients with HIV and hepatitis C virus coinfection
    Nazifa Qurishi
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Lancet 362:1708-13. 2003
    ..To clarify the effect of HAART in HIV/HCV-coinfected patients, we studied liver-related mortality and overall mortality in 285 patients who were regularly treated during the period 1990-2002 at our department...
  11. ncbi [Clinical characteristics of 159 cases of acute toxic hepatitis]
    Sun Hyung Kang
    Department of Gastroenterology and Hepatology, College of Medicine, Chungnam National University, Daejeon, Korea
    Korean J Hepatol 14:483-92. 2008
    b>Toxic hepatitis has recently been discovered to be a major cause of acute hepatitis. We studied the clinical features and prognosis of patients diagnosed with toxic hepatitis at a single institution.
  12. ncbi Histopathology of acetaminophen-induced liver changes: role of interleukin 1 alpha and tumor necrosis factor alpha
    M E Blazka
    Environmental Immunology and Neurobiology Section, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 24:181-9. 1996
    ..These results suggest that TNF-alpha and IL-1 alpha play an important role in the degree of damage and recovery that the liver undergoes following APAP intoxication...
  13. pmc Making a diagnosis of herbal-related toxic hepatitis
    Christine A Haller
    California Poison Control System and Department of Medicine, Division of Clinical Pharmacology Box 1220 University of California, San Francisco UCSF San Francisco, CA 94143 1220, USA
    West J Med 176:39-44. 2002
  14. ncbi Incidence of and risk factors for severe hepatotoxicity associated with antiretroviral combination therapy
    Ferdinand W N M Wit
    National AIDS Therapy Evaluation Center, Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Infect Dis 186:23-31. 2002
    ..In 97% of cases, >or=1 risk factor was present. In HBV-coinfected patients using 3TC, continued use of 3TC should be considered, even if 3TC-resistant HIV strains develop...
  15. pmc Ceftriaxone-induced toxic hepatitis
    Erdal Peker
    Department of Pediatrics, Medical University of Yuzuncu Yil, 65100 Van, Turkey
    World J Gastroenterol 15:2669-71. 2009
    b>Toxic hepatitis or drug-induced liver injury encompasses a spectrum of clinical disease ranging from mild biochemical abnormalities to acute liver failure...
  16. ncbi Methylprednisolone-induced toxic hepatitis
    Firdevs Topal
    Department of Gastroenterology, Numune Education and Training Hospital, Ankara, Turkey
    Ann Pharmacother 40:1868-71. 2006
    To report the third published case, as of April 8, 2006, of methylprednisolone-induced toxic hepatitis.
  17. ncbi Effect of Sargassum polycystum (Phaeophyceae)-sulphated polysaccharide extract against acetaminophen-induced hyperlipidemia during toxic hepatitis in experimental rats
    Hanumantha Rao Balaji Raghavendran
    Department of Biochemistry, University of Madras, Guindy Campus, Chennai, Tamilnadu 600 025, India
    Mol Cell Biochem 276:89-96. 2005
    ..intraperitoneally) hyperlipidemia during toxic hepatitis in experimental rats...
  18. ncbi Toxic hepatitis associated with paroxetine
    O Colakoglu
    Gastroenterology Clinics, Ataturk Training and Research Hospital, Izmir, Turkey
    Int J Clin Pract 59:861-2. 2005
    ..We report here severe adverse cholestatic and hepatocellular injury in a patient taking paroxetine probably due to an immune-mediated hypersensitivity reaction...
  19. ncbi [Forensic-medical evaluation of toxic hepatitis associated with surrogate alcohol poisoning]
    Iu V Solodun
    Sud Med Ekspert 51:23-8. 2008
    ..Changes in hepatocytes of different type and genesis appear to be due to other toxic components and may be of use for the establishment of causal relation between hepatic lesions and concrete toxic mixtures...
  20. ncbi Prevention of severe toxic liver injury and oxidative stress in MCP-1-deficient mice
    Elena Zamara
    Dipartimento di Medicina e Oncologia Sperimentale, University of Turin, Italy
    J Hepatol 46:230-8. 2007
    ..In this study, we investigated the development of acute toxic damage in mice lacking monocyte chemoattractant protein-1 (MCP-1), a chemokine which recruits monocytes and activated lymphocytes...
  21. ncbi Comparative treatment of alpha-amanitin poisoning with N-acetylcysteine, benzylpenicillin, cimetidine, thioctic acid, and silybin in a murine model
    Tri C Tong
    University of California San Diego Medical Center, Division of Medical Toxicology, Department of Emergency Medicine, San Diego, CA 92103, USA
    Ann Emerg Med 50:282-8. 2007
    ..We compare the effectiveness of 5 potential antidotal therapies in limiting the degree of hepatonecrosis in a randomized, controlled, murine model of amatoxin-induced hepatotoxicity...
  22. ncbi [Toxic hepatitis associated with carp juice ingestion]
    Hye Suk Son
    Department of Internal Medicine, Daejeon St Mary s Hospital Medical College of the Catholic University of Korea
    Korean J Hepatol 12:103-6. 2006
    ..There have been cases showing the toxic hepatitis and renal failure associated with the ingestion of raw carp bile...
  23. ncbi Acute toxic hepatitis after amiodarone intravenous loading
    Emanuela Rizzioli
    Department of Internal Medicine, Hospital of the Delta, Lagosanto, Ferrara, Italy
    Am J Emerg Med 25:1082.e1-4. 2007
  24. ncbi Antioxidant effect of Sargassum polycystum (Phaeophyceae) against acetaminophen induced changes in hepatic mitochondrial enzymes during toxic hepatitis
    Hanumantha Rao Balaji Raghavendran
    Department of Biochemistry, University of Madras, Guindy Campus, Patel Road, Chennai 600 025, India
    Chemosphere 61:276-81. 2005
    ..Phaeophyceae) alcoholic extract on changes in liver mitochondrial enzymes against acetaminophen induced toxic hepatitis in experimental rats...
  25. ncbi Drug-induced liver injury: summary of a single topic clinical research conference
    Paul B Watkins
    University of North Carolina, Chapel Hill, NC, USA
    Hepatology 43:618-31. 2006
    ..The presentations spanned many different areas of DILI, and included novel data concerning mechanisms of hepatotoxicity, new "omics" approaches, and the challenges of improving causation assessment...
  26. ncbi [Imatinib-induced toxic hepatitis: description of two cases and review of the literature]
    Francisco Fuster
    Departamento de Gastroenterología Hospital Naval Viña del Mar Chile
    Gastroenterol Hepatol 30:525-30. 2007
    ..The use of this drug is safe, although some cases of imatinib-induced toxic hepatitis have been reported...
  27. ncbi [Acute toxic hepatitis: RUCAM application to drug-induced liver injury and its limitations]
    Byung Min Ahn
    Department of Internal Medicine, Laboratory of Disease Specific Dietary Supplements, Bupyeong Serim Hospital, Incheon, Korea
    Korean J Hepatol 12:1-4. 2006
  28. ncbi Inactive hepatitis B surface antigen carrier state and hepatotoxicity during antituberculosis chemotherapy
    Byoung Hoon Lee
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon Dong, Kangnam Ku, Seoul 135 710, Korea
    Chest 127:1304-11. 2005
    ....
  29. ncbi Recurrent toxic hepatitis in a Caucasian girl related to the use of Shou-Wu-Pian, a Chinese herbal preparation
    Bianca Panis
    Department of Pediatrics, Maasland Hospital, Sittard, The Netherlands
    J Pediatr Gastroenterol Nutr 41:256-8. 2005
  30. pmc Grand rounds: an outbreak of toxic hepatitis among industrial waste disposal workers
    Hae Kwan Cheong
    Department of Social and Preventive Medicine, Sungkyunkwan University School of Medicine, Suwon, Korea
    Environ Health Perspect 115:107-12. 2007
    ....
  31. ncbi Oxidative stress, toxic hepatitis, and antioxidants with particular emphasis on zinc
    William E Stehbens
    Department of Pathology and Molecular Medicine, Wellington School of Medicine and Health Sciences, P O Box 7343, Wellington South, New Zealand
    Exp Mol Pathol 75:265-76. 2003
    ..Therefore reassessment of optimal prophylactic and therapeutic nutritional requirements of antioxidants (particularly zinc) to defend humans against xenobiotic induced oxidative stress is advocated...
  32. ncbi Prolonged infusion of angiotensin II into normal rats induces stellate cell activation and proinflammatory events in liver
    Ramon Bataller
    Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7032, USA
    Am J Physiol Gastrointest Liver Physiol 285:G642-51. 2003
    ..In conclusion, increased systemic ANG II can induce liver injury by promoting proinflammatory events and vascular damage. ANG II-induced hepatic effects are not dependent on increase in arterial pressure...
  33. ncbi [Clinical experience of 48 acute toxic hepatitis patients]
    Jeong Chul Seo
    Department of Internal Medicine, College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Korea
    Korean J Hepatol 12:74-81. 2006
    Although many individual cases of toxic hepatitis have been reported in Korea, there are few comprehensive systematic studies on acute toxic hepatitis...
  34. ncbi Hepatobiliary clearance of labelled mebrofenin in normal and D-galactosamine HCl-induced hepatitis rats and the protective effect of turmeric extract
    U R Deshpande
    Radiation Medicine Centre B A R C, Tata Memorial Hospital Annexe, Parel, Mumbai 400 012
    Indian J Physiol Pharmacol 47:332-6. 2003
    ..Hence, it can be suggested that turmeric extract may improve the liver function by detoxification...
  35. ncbi Hepatotoxicity of carbon tetrachloride: protective effect of Gongronema latifolium
    O E Etim
    Department of Biochemistry, Faculty of Basic Medical Sciences, University of Uyo, Uyo, Nigeria
    Pak J Pharm Sci 21:268-74. 2008
    ..The protective effect of the GLE was more pronounced in ALT and AST. However, the GLE has a strong modulatory effect against the hepatocellular damage induced by carbon tetrachloride...
  36. ncbi Hyaluronic acid and chondroitin-4-sulphate treatment reduces damage in carbon tetrachloride-induced acute rat liver injury
    Giuseppe M Campo
    Department of Biochemical, Physiological and Nutritional Sciences, School of Medicine, University of Messina, Policlinico Universitario, Torre Biologica, 5 piano, Via C Valeria, 98100 Messina, Italy
    Life Sci 74:1289-305. 2004
    ....
  37. ncbi Protective effect of acteoside on carbon tetrachloride-induced hepatotoxicity
    Kyung Jin Lee
    Department of Pharmacy, College of Pharmacy, Research Center for Proteineous Materials, Chosun University, 375 Seosuk dong, Kwangju 501 759, South Korea
    Life Sci 74:1051-64. 2004
    ....
  38. ncbi [Protective effect of Isodon lophanthoides var. gerardianus on acute hepatic injury induced by carbon tetrachloride in rats]
    Yukiko Nagao
    New Drug Research and Development Center, Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, China
    Zhongguo Zhong Yao Za Zhi 31:574-7. 2006
    ..To study the protective effects of Isodon lophanthoides var. gerardianus (ILVG) aqueous extract on the acute hepatic injury induced by carbon tetrachloride (CCl4) in rats...
  39. ncbi [Effects of ursolic acid on liver-protection and bile secretion]
    Xiaojuan Xiong
    Yichun College, Yichun, Jiangxi 336000
    Zhong Yao Cai 26:578-81. 2003
    ..To study the liver-protection and promoting bile secretion of ursolic acid...
  40. ncbi Carbon tetrachloride-induced acute liver injury in Mini and Wistar rats
    H Shimizu
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    Exp Toxicol Pathol 53:11-7. 2001
    ..These results indicate that the response of the liver to CCl4 is different between GH-suppressed Mini rats and Wistar rats...
  41. ncbi Hepatoprotective activity of the Indian medicinal plant Polygala arvensis on D-galactosamine-induced hepatic injury in rats
    S P Dhanabal
    Department of Pharmacognosy and Pharmacology, JSS College of Pharmacy, Rocklands, Oootacamund 643001Tamilnadu, India
    Fitoterapia 77:472-4. 2006
    ..001) increased in rats by treatment with 400 mg/kg i.p. of d-galactosamine. Silymarin (25 mg/kg), a known hepatoprotective drug used for comparison exhibited significant activity (P<0.001)...
  42. ncbi Antioxidant activity of the oyster mushroom, Pleurotus ostreatus, on CCl(4)-induced liver injury in rats
    T Jayakumar
    Department of Animal Science, Bharathidasan University, Tiruchirappalli 620024, Tamil Nadu, India
    Food Chem Toxicol 44:1989-96. 2006
    ..ostreatus. These results suggest that an extract of P. ostreatus is able to significantly alleviate the hepatotoxicity induced by CCl(4) in the rat...
  43. ncbi Hepatoprotective potentials of Phyllanthusamarus against ethanol-induced oxidative stress in rats
    Toyin Y Faremi
    Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Food Chem Toxicol 46:2658-64. 2008
    ..amarus co-treatment. Results show that P. amarus leaf extract could protect the liver against ethanol-induced oxidative damage by possibly reducing the rate of lipid peroxidation and increasing the antioxidant defence mechanism in rats...
  44. ncbi Moringa oleifera Lam prevents acetaminophen induced liver injury through restoration of glutathione level
    S Fakurazi
    Pharmacology Unit, Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
    Food Chem Toxicol 46:2611-5. 2008
    ..The histological hepatocellular deterioration was also evidenced. The results from the present study suggested that the leaves of MO can prevent hepatic injuries from APAP induced through preventing the decline of glutathione level...
  45. ncbi Effect of propriety herbal formulation against chronic carbon tetrachloride induced hepatotoxicity
    Monika Bhadauria
    School of Studies in Zoology, Jiwaji University, Gwalior 474011, India
    Indian J Exp Biol 40:1254-9. 2002
    ..Cell organelles like mitochondria, endoplasmic reticulum and nucleus showed severe degeneration after CCl4 exposure. PHF was effective in restoring the CCl4 induced biochemical and histological ultrastructural changes...
  46. ncbi Protective effect of fenugreek (Trigonella foenum graecum) seeds in experimental ethanol toxicity
    V Thirunavukkarasu
    Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar, Tamil Nadu, India
    Phytother Res 17:737-43. 2003
    ..Further, histopathological examination of liver and brain revealed that, aqueous extract of fenugreek seeds could offer a significant protection against ethanol toxicity...
  47. ncbi Dynamic changes of heme oxygenase-1 and carbon monoxide production in acute liver injury induced by carbon tetrachloride in rats
    Tao Wen
    Research Center of Occupational Medicine, the Third Hospital of Peking University, Beijing, PR China
    Toxicology 228:51-7. 2006
    ..It therefore suggested that more relevant studies should be carried out in the future to clarify the detailed mechanisms...
  48. ncbi Hepatoprotective and antioxidant effects of Commiphora berryi (Arn) Engl bark extract against CCl(4)-induced oxidative damage in rats
    N L Gowri Shankar
    Department of Pharmacognosy, Swamy Vivekananda Institute of Pharmaceutical Sciences, Andhra Pradesh, India
    Food Chem Toxicol 46:3182-5. 2008
    ..berryi (Arn) Engl bark can be proposed to protect the liver against CCl(4)-induced oxidative damage in rats, and the hepatoprotective effect might be correlated with its antioxidant and free radical scavenger effects...
  49. ncbi Antioxidant activities of isoflavones from the rhizomes of Belamcanda chinensis on carbon tetrachloride-induced hepatic injury in rats
    Sang Hoon Jung
    Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 110 460, Korea
    Arch Pharm Res 27:184-8. 2004
    ..These results suggested that tectorigenin and tectoridin isolated from the rhizomes of B. chinensis possess not only the antioxidative, but also the hepatoprotective activities in CCl4-intoxicated rats...
  50. ncbi Mechanisms of apigenin-7-glucoside as a hepatoprotective agent
    Qiu Sheng Zheng
    Department of Biochemistry, Yantai University, Yantai, Shandong 264005, China
    Biomed Environ Sci 18:65-70. 2005
    ..chinesis. In the present study the effects of apigenin-7-glucoside (APIG) isolated from I. chinesis against liver injury caused by carbon tetrachloride (CCl4) were investigated...
  51. ncbi Mechanism of protective action of bicyclol against CCl-induced liver injury in mice
    Geng Tao Liu
    Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Liver Int 25:872-9. 2005
    ..These results suggest that bicyclol has remarkable hepatoprotective effects and its mechanism of action may be related to a decrease in free radical-induced damage to hepatocytes...
  52. ncbi Protective value of Aloe vera against some toxic effects of arsenic in rats
    Richa Gupta
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474 002, India
    Phytother Res 19:23-8. 2005
    ..The results thus lead us to conclude that simultaneous supplementation of Aloe vera protects against arsenic induced oxidative stress but does not influence the arsenic concentration in these organs...
  53. ncbi Metabonomic evaluation of idiosyncrasy-like liver injury in rats cotreated with ranitidine and lipopolysaccharide
    Jane F Maddox
    Department of Pharmacology and Toxicology, National Food Safety and Toxicology Center, Center for Integrative Toxicology, Michigan State University, East Lansing, MI 48824, USA
    Toxicol Appl Pharmacol 212:35-44. 2006
    ..These findings support the potential use of a noninvasive metabonomic approach to identify drug candidates with potential to cause idiosyncratic liver toxicity with inflammagen coexposure...
  54. pmc Alterations of mast cells and TGF-beta1 on the silymarin treatment for CCl(4)-induced hepatic fibrosis
    Da Hee Jeong
    College of Veterinary Medicine, Kyungpook National University, Daegu 702 701, Republic of Korea
    World J Gastroenterol 11:1141-8. 2005
    ..Especially, in hepatic fibrogenesis, mast cells are expressed in chronic inflammatory conditions, and promote fibroblast growth and stimulate production of the extracellular matrix by hepatic stellate cells...
  55. ncbi Hepatoprotective effect of the natural fruit juice from Aronia melanocarpa on carbon tetrachloride-induced acute liver damage in rats
    S Valcheva-Kuzmanova
    Department of Preclinical and Clinical Pharmacology and Biochemistry, Medical University, 9002 Varna, Bulgaria
    Exp Toxicol Pathol 56:195-201. 2004
    ..2ml kg(-1), 3rd and 4th days). NFJAM also prevented the CCl4-induced elevation of MDA formation and depletion of GSH content in rat liver...
  56. ncbi Protective effect of Lycium chinense fruit on carbon tetrachloride-induced hepatotoxicity
    Ki Tae Ha
    Department of Pathology, Biochemistry and Molecular Biology, College of Oriental Medicine, Dongguk University, 707 Suk Jang Dong, Kyungju City, Kyungbuk 780 714, Korea
    J Ethnopharmacol 96:529-35. 2005
    ..Based on these results, it was suggested that the hepatoprotective effects of the LFE might be related to antioxidative activity and expressional regulation of CYP2E1...
  57. ncbi Nanoparticles formulation of Cuscuta chinensis prevents acetaminophen-induced hepatotoxicity in rats
    Feng Lin Yen
    Graduate Institute of Pharmaceutical Sciences, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan
    Food Chem Toxicol 46:1771-7. 2008
    ..In conclusion, we suggest that the nanoparticles system can be applied to overcome other water poorly soluble herbal medicines and furthermore to decrease the treatment dosage...
  58. ncbi Serum hyaluronan and hyaluronidase: very early markers of toxic liver injury
    Joseph George
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY 10032, USA
    Clin Chim Acta 348:189-97. 2004
    ..We test the hypothesis that elevated levels of circulating hyaluronan and hyaluronidase could provide indicators of very early liver damage...
  59. ncbi Protection of hepatotoxic and lethal effects of CCl4 by partial hepatectomy
    P R Kodavanti
    Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson 39216
    Toxicol Pathol 17:494-505. 1989
    ..By virtue of the much stronger stimulatory effect, PH results in the protection against the hepatotoxic and lethal effects of CCl4 despite the obtunding effects of the high dose on hepatocellular regeneration...
  60. ncbi Effect of pentoxifylline on hepatic injury caused in the rat by the administration of carbon tetrachloride or acetaminophen
    Omar M E Abdel Salam
    Department of Pharmacology, National Research Centre, Tahrir St, Dokki, Cairo, Egypt
    Pharmacol Rep 57:596-603. 2005
    ..In contrast, PTX is equally protective, when given either as a pretreatment or with acetaminophen exposure...
  61. ncbi Histological and lipid peroxidation changes after administration of 2-acetylaminofluorene in a rat liver injury model following selective periportal and pericentral damage
    Fragiska Sigala
    First Department of Surgery, University of Athens, Medical School, Laikon General Hospital, 17 Agiou Thoma Street, 11527 Athens, Greece
    Toxicology 196:155-63. 2004
    ..In conclusion, it appears that oxidative stress was correlated with liver necrosis and with liver regeneration. Suppression of liver regeneration after 2-AAF administration leads to lower malondialdehyde concentrations...
  62. ncbi Antioxidative natural product protect against econazole-induced liver injuries
    Chi Feng Liu
    National Taipei College of Nursing, Taipei 112, Taiwan
    Toxicology 196:87-93. 2004
    ..It could be postulated that the hepatoprotective effect of PEE may be, at least in part, due to their inhibitory ability on membrane lipid peroxidation and free radical formation or due to their free radical scavenging ability...
  63. ncbi Antihepatotoxic activity of seeds of Cichorium intybus
    Bahar Ahmed
    Antihepatotoxic Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, 110062, New Delhi, India
    J Ethnopharmacol 87:237-40. 2003
    ..The histopathological study of the liver was also carried out, wherein the methanolic fraction and compound AB-IV showed almost complete normalization of the tissues as neither fatty accumulation nor necrosis was observed...
  64. ncbi Effect of Holotrichia diomphalia larvae on liver fibrosis and hepatotoxicity in rats
    Woo Yong Oh
    College of Pharmacy, Sungkyunkwan University, 300 Chonchon dong, Changan gu, 440 746, Kyunggi Do, Suwon, South Korea
    J Ethnopharmacol 87:175-80. 2003
    ..The present results led us to conclude that Holotrichia diomphalia larvae can reduce the degree of hepatocellular damage and may become a promising antifibrotic agent for liver fibrosis/cirrhosis...
  65. ncbi Effect of the carotenoid-producing alga, Dunaliella bardawil, on CCl4-induced toxicity in rats
    A Vanitha
    Plant Cell Biotechnology Department, Central Food Technological Research Institute, Mysore, Karnataka, 570020, India
    Int J Toxicol 26:159-67. 2007
    ..Liver histopathology was less severe with D. bardawil treatment, supporting the apparent protective action of 14-day treatment on hepatic oxidative injury...
  66. ncbi Protective effects of amburoside A, a phenol glucoside from Amburana cearensis, against CCl4-induced hepatotoxicity in rats
    Luzia K Leal
    Departmento de Farmacia, Universidade Federal do Ceara, Rua Capitão Francisco Pedro 1210, Fortaleza, Brazil
    Planta Med 74:497-502. 2008
    ..Our results indicate that CCl (4)-induced oxidative damage in hepatic tissues is reversed by AMB treatment. The protective effect of AMB is probably due to the phenolic nature of this glucoside...
  67. ncbi Antihepatotoxic activity of Phyllanthus fraternus
    B Ahmed
    Antihepatotoxic Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India
    Pharmazie 57:855-6. 2002
    ....
  68. ncbi Hepatoprotective and antihyperliposis activities of in vitro cultured Anoectochilus formosanus
    Xiao Ming Du
    Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Phytother Res 17:30-3. 2003
    ....
  69. ncbi Evaluation of protective effects of Chi-Zhi-Huang decoction on Phase I drug metabolism of liver injured rats by cocktail probe drugs
    Hao Tang
    Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, PR China
    J Ethnopharmacol 117:420-6. 2008
    ..In this research, we aim at to evaluate the potential activity of PGR in restoring hepatic drug metabolism in a damaged liver...
  70. ncbi Chromatin breakdown by deoxyribonuclease1 promotes acetaminophen-induced liver necrosis: an ultrastructural and histochemical study on male CD-1 mice
    Monika Jacob
    Abteilung für Anatomie und Embryologie, Medizinische Fakultat, Ruhr Universitat Bochum, Universitatsstrasse 150, 44801 Bochum, Germany
    Histochem Cell Biol 128:19-33. 2007
    ....
  71. ncbi Hepatoprotective effects of Ganoderma lucidum peptides against D-galactosamine-induced liver injury in mice
    Yanling Shi
    College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, People s Republic of China
    J Ethnopharmacol 117:415-9. 2008
    ..Results of this study revealed that GLP could afford a significant protection in the alleviation of d-GalN-induced hepatocellular injury...
  72. ncbi Prophylactic effect of four prescriptions of traditional Chinese medicine on alpha-naphthylisothiocyanate and carbon tetrachloride induced toxicity in rats
    K J Lin
    Department of Surgery, China Medical College-Hospital, Taichung, Taiwan, China
    Acta Pharmacol Sin 22:1159-67. 2001
    ..Therefore they may be able to exert hepatoprotective effects through more than one mechanism of action because they contained a mixture of anti-hepatotoxic ingredients with mutual reinforcement and assistance...
  73. ncbi The influence of small doses of paracetamol on rabbit liver
    Izabela Maciejewska-Paszek
    Department of Food and Nutrition, Medical University of Silesia, 41 200 Sosnowiec, Jagiellońska 4 Street, Katowice, Poland
    Exp Toxicol Pathol 59:139-41. 2007
    ..It was determined by measuring the concentration of ketone bodies and arterial ketone body ratio (AKBR) value. Even when taken in small doses, paracetamol causes changes in liver metabolism when taken for an extended period of time...
  74. ncbi Hepatoprotective and immunomodulatory properties of Tinospora cordifolia in CCl4 intoxicated mature albino rats
    Biswadev Bishayi
    Department of Physiology, Immunology Laboratory, University of Calcutta, 92, A P C Road, Calcutta 700 009, India
    J Toxicol Sci 27:139-46. 2002
    ..cordifolia treatment. The results of our experiment suggest that treatment by T. cordifolia extract may be the critical remedy for the adverse effect of CCl4 in liver function as well as immune functions...
  75. pmc Comprehensive characterization of serum clinical chemistry parameters and the identification of urinary superoxide dismutase in a carbon tetrachloride-induced model of hepatic fibrosis in the female Hanover Wistar rat
    Rosemary Smyth
    Department of Pharmaceutical and Biological Chemistry, The School of Pharmacy, University of London, London, UK
    Int J Exp Pathol 88:361-76. 2007
    ..Western blotting revealed that SOD was increased in urine from rats treated with CCl(4) at 3 and 6 weeks, but not at 9 and 12 weeks. We conclude that Cu/Zn SOD is a urinary marker of hepatic necrosis, but not hepatic fibrosis...
  76. ncbi Protection by and anti-oxidant mechanism of berberine against rat liver fibrosis induced by multiple hepatotoxic factors
    Ben Jian Zhang
    Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan, China
    Clin Exp Pharmacol Physiol 35:303-9. 2008
    ..01). 4. These results suggest that berberine could be used to prevent experimental liver fibrosis through regulation of the anti-oxidant system and lipid peroxidation...
  77. ncbi The effect of beta-cyclodextrin complexation on the bioavailability and hepatotoxicity of clotrimazole
    C S Yong
    College of Pharmacy, Yeungnam University, Gyeongsan, South Korea
    Pharmazie 62:756-9. 2007
    ..Our results suggest that, in the development of a novel oral product, appearance or enhancement of hepatic toxicity must be considered along with oral bioavailability...
  78. ncbi Hepatoprotective effect of Foeniculum vulgare essential oil
    H Ozbek
    Yuzuncu Yil University, Faculty of Medicine, Department of Pharmacology, Van 65300, Turkey
    Fitoterapia 74:317-9. 2003
    ..The results of this study indicate that FEO has a potent hepatoprotective action against CCl(4)-induced hepatic damage in rats...
  79. ncbi Evaluation of hepatoprotective effect of Gentiana olivieri herbs on subacute administration and isolation of active principle
    Didem Deliorman Orhan
    Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler 06330, Ankara, Turkey
    Life Sci 72:2273-83. 2003
    ..Isoorientin exhibited significant hepatoprotective effect at 15 mg/kg b.w. dose...
  80. ncbi Overexpression of the gene for transmembrane 4 superfamily member 4 accelerates liver damage in rats treated with CCl4
    Jie Qiu
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, People s Republic of China
    J Hepatol 46:266-75. 2007
    ..Therefore, we investigated the role of TM4SF4 during liver injury...
  81. ncbi Type 1 diabetic mice are protected from acetaminophen hepatotoxicity
    Kartik Shankar
    Department of Toxicology, School of Pharmacy, The University of Louisiana at Monroe, Monroe, Louisiana 71209, USA
    Toxicol Sci 73:220-34. 2003
    ..In conclusion, the resistance of DB mice against hepatotoxic and lethal effects of APAP appears to be mediated by a combination of enhanced APAP clearance and robust compensatory tissue repair...
  82. ncbi RAT CYP3A and CYP2B1/2 were not associated with nevirapine-induced hepatotoxicity
    A Walubo
    The Department of Pharmacology, University of the Free State, Bloemfontein, South Africa
    Methods Find Exp Clin Pharmacol 28:423-31. 2006
    ..However, this is yet to be proven in humans...
  83. ncbi Pharmacological modification of endogenous antioxidant enzymes by ursolic acid on tetrachloride-induced liver damage in rats and primary cultures of rat hepatocytes
    S Martin-Aragon
    Dpto Farmacologia, Facultad de Farmacia Universidad Complutense de Madrid, Spain
    Exp Toxicol Pathol 53:199-206. 2001
    ....
  84. ncbi Protective mechanism of salvia miltiorrhiza on carbon tetrachloride-induced acute hepatotoxicity in rats
    Tzung Yan Lee
    Institute of Traditional Medicine, National Yang Ming University School of Medicine, Taiwan
    J Pharmacol Sci 91:202-10. 2003
    ..This effect may be due to its ability to decrease the metabolic activation of CCl(4) by an increase in P450 2E1 protein content and its antioxidant activity associated with less increase in hepatic iNOS protein content...
  85. ncbi Protective effect of Indigofera aspalathoides against CCl4-induced hepatic damage in rats
    B Rajkapoor
    Department of Pharmacology, Vinayaka Mission s College of Pharmacy, Yercaud Road, Salem 636 008, Tamilnadu, India
    J Herb Pharmacother 6:49-54. 2006
    ..The histopathological changes of liver sample were compared with respective control. The extract showed remarkable hepatoprotective effect...
  86. ncbi The effectiveness of Tsu-San-Li (St-36) and Tai-Chung (Li-3) acupoints for treatment of acute liver damage in rats
    H J Liu
    Acupuncture Research Center, Graduate Institute of Traditional Chinese Medicine, Taoyuan, Taiwan
    Am J Chin Med 29:221-6. 2001
    ..Acupuncture at the Tsu-San-Li and Tai-Chung acupoints cannot prevent acute liver injury but may be effective in treating liver injury induced by carbon tetrachloride in rats...
  87. ncbi Optimization of the dose and route of injection, and characterisation of the time course of carbon tetrachloride-induced hepatotoxicity in the rat
    Sana Janakat
    Department of Nutrition and Food Technology, Jordan University of Science and Technology, P O Box 3030, Irbid, Jordan
    J Pharmacol Toxicol Methods 48:41-4. 2002
    ..The purpose of this study was to optimize carbon tetrachloride-induced hepatotoxicity in the rat with respect to dose, route of injection, and time course...
  88. ncbi Protective effect of polysaccharides-enriched fraction from Angelica sinensis on hepatic injury
    Y N Ye
    Department of Pharmacology, Faculty of Medicine, The University of Hong Kong, China
    Life Sci 69:637-46. 2001
    ..AP is more effective in the protection against liver damage induced by acetaminophen, which is associated with the glutathione depletion and nitric oxide synthase activation in the liver...
  89. ncbi Hepatoprotective effect of the extract and isocytisoside from Aquilegia vulgaris
    T Adamska
    Department of Toxicology, K Marcinkowski University of Medical Sciences, Dojazd 30, 60 631 Poznan, Poland
    Phytother Res 17:691-6. 2003
    ..The hepatoprotective properties of AvEE and ISOC were con fi rmed by pathomorphological examination of the liver...
  90. ncbi Efficacy of different Cynara scolymus preparations on liver complaints
    E Speroni
    Department of Pharmacology, University of Bologna, Via Irnerio 48, Italy
    J Ethnopharmacol 86:203-11. 2003
    ..Perhaps caffeoyl derivatives have a role in the therapeutic properties of C. scolymus extracts, as reported in literature for "in vitro" studies, but when administered alone, they are not so effective in exerting this action...
  91. ncbi Radioiodine therapy in patients with amiodarone-induced thyrotoxicosis (AIT)
    Agata Czarnywojtek
    Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poland
    Neuro Endocrinol Lett 30:209-14. 2009
    ..In these patients therapeutic choices for refractory disease include surgery, antithyroid drugs, or glu ocorticosteriods...
  92. pmc Defensive nature of Sargassum polycystum (Brown alga) against acetaminophen-induced toxic hepatitis in rats: role of drug metabolizing microsomal enzyme system, tumor necrosis factor-alpha and fate of liver cell structural integrity
    H Balaji Raghavendran
    Department of Biochemistry, University of Madras, Guindy Campus, Chennai, India
    World J Gastroenterol 12:3829-34. 2006
    ..polycystum) (Brown alga) against acetaminophen (AAP)-induced changes in drug metabolizing microsomal enzyme system, tumor necrosis factor (TNF-alpha) and fine structural features of the liver during toxic hepatitis in rats.
  93. ncbi Superoxide anion production by the mitochondrial respiratory chain of hepatocytes of rats with experimental toxic hepatitis
    A Shiryaeva
    Laboratory of Cell Pathology, Institute of Cytology RAS, Tikhoretski Ave, 4, St Petersburg, 194064, Russia
    J Bioenerg Biomembr 41:379-85. 2009
    The progression of toxic hepatitis is accompanied by the activation of oxidative processes in the liver associated with an enhancement of the mitochondrial respiratory chain activity and superoxide anion production (O(2)(*-))...
  94. pmc Validation of ICD-9-CM/ICD-10 coding algorithms for the identification of patients with acetaminophen overdose and hepatotoxicity using administrative data
    Robert P Myers
    Liver Unit, Division of Gastroenterology, Department of Medicine University of Calgary, Calgary, Alberta, Canada
    BMC Health Serv Res 7:159. 2007
    ..Acetaminophen overdose is the most common cause of acute liver failure (ALF). Our objective was to develop coding algorithms using administrative data for identifying patients with acetaminophen overdose and hepatic complications...
  95. ncbi Pediatric liver transplantation for acute liver failure
    H Karakayali
    Department of General Surgery, Baskent University Faculty of Medicine, Ankara, Turkey
    Transplant Proc 39:1157-60. 2007
    ..1); fulminant Wilson's disease (3); Amanita phalloides (mushroom) poisoning (1); and hepatitis B and toxic hepatitis with leflunomide treatment (1). Seven of the participants were female and five were male (mean age, 9.1 +/- 4...
  96. ncbi Relationship between leptin, insulin, body composition and liver steatosis in non-diabetic moderate drinkers with normal transaminase levels
    Silvia Valtuena
    Department of Internal Medicine and Biomedical Sciences, University of Parma, Italy
    Eur J Endocrinol 153:283-90. 2005
    ..Our objective was to investigate the relationship between serum leptin, insulin, obesity and LS in non-diabetic males (n = 74) and postmenopausal females (n = 50) with normal transaminase levels and low-to-moderate alcohol intake...
  97. ncbi Mycophenolate mofetil in anti-MPO renal vasculitis: an alternative therapy in case of cyclophosphamide or azathioprine toxicity
    M Ibernon
    Department of Nephrology, Hospital Universitari de Bellvitge, Barcelona, Spain
    Clin Nephrol 69:395-401. 2008
    ..However, this regimen is associated with high toxicity. Mycophenolate mofetil (MMF), a less toxic immunosuppressive drug, has been proposed as a therapeutic alternative...
  98. ncbi Acute arsenic poisoning treated by intravenous dimercaptosuccinic acid (DMSA) and combined extrarenal epuration techniques
    Philippe Hantson
    Department of Intensive Care, Cliniques St Luc, Universite Catholique de Louvain, Brussels, Belgium
    J Toxicol Clin Toxicol 41:1-6. 2003
    ..The patient developed severe manifestations of toxic hepatitis and pancreatitis, and thereafter neurological disorders, respiratory distress, acute renal failure, and ..
  99. ncbi Prenatal exposure to methamphetamine presenting as neonatal cholestasis
    Ahmed Dahshan
    Department of Pediatrics, Division of Pediatric Gastroenterology, Oklahoma University Health Sciences Center Tulsa, Tulsa, OK 74135, USA
    J Clin Gastroenterol 43:88-90. 2009
    Methamphetamine has been recognized as a common cause of acute toxic hepatitis in adults with clinical and histologic features indistinguishable from acute viral hepatitis...
  100. ncbi Fulminant hepatic failure in children: etiology, histopathology and MDCT findings
    Banu Cakir
    Baskent University Faculty of Medicine Department of Radiology, Fevzi Cakmak Cd 10, Sok No 45, Bahcelievler, Ankara, Turkey
    Eur J Radiol 72:327-34. 2009
    ..The purpose of this study is to determine the etiologies, histopathology and MDCT findings of children with fulminant hepatic failure admitted to our institution...
  101. ncbi [A study of the clinical classification of 3638 cases of mushroom poisoning]
    Cheng shan Ren
    Department of Internal Medicine, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China
    Zhonghua Nei Ke Za Zhi 46:229-32. 2007
    ..To study the clinical classification and characteristics as well as prognosis of mushroom poisoning...

Research Grants46

  1. Mechanisms of experimental drug-induced hepatitis
    Dolores Njoku; Fiscal Year: 2007
    ..3) To confirm antigenic spread in TFA-CYP2E1-immunized mice using spleenocyte proliferation assays stimulated with ERp58 and ASGPR and analyzed as in Specific Aim 2. [unreadable] [unreadable] [unreadable] [unreadable]..
  2. FURANOCOUMARINS AND DRUGS EFFECT ON CYP3A4
    Paul Watkins; Fiscal Year: 2007
    ..abstract_text> ..
  3. Alcoholic Hepatitis: Molecular Mechanisms
    Stephen Safe; Fiscal Year: 2008
    ..The long-term goal of this project is to device appropriate therapies that will prevent neutrophilic steatohepatitis in chronic alcoholics by reducing neutrophil infiltration into liver. [unreadable] [unreadable] [unreadable]..
  4. Nitogen reduction and xenobiotic response
    Lauren A Trepanier; Fiscal Year: 2010
    ..The ultimate goal of these studies is to find better ways to prevent these adverse reactions. ..
  5. GENERAL CLINICAL RESEARCH CENTERS ANNUAL MEETING
    Paul Watkins; Fiscal Year: 2006
    ..abstract_text> ..
  6. TUMOR NECROSIS FACTOR INVOLVEMENT IN FUMONISIN TOXICITY
    RAGHUBIR SHARMA; Fiscal Year: 2001
    ..Results will help in defining the mechanism(s) of fumonisin toxicity, causes of species-specificity, and provide a better appraisal of risk in humans, including modification of fumonisin response by gram-negative infections. ..
  7. Liver innate immunity in drug-induced liver disease
    Zhang Xu Liu; Fiscal Year: 2006
    ..Kaplowitz and the center members at the outstanding environment of USC Research Center for Liver Diseases. ..
  8. Mechanism of Compensatory Tissue Repair in Renal Injury
    HARIHARA MEHENDALE; Fiscal Year: 2006
    ..abstract_text> ..
  9. Genetic Basis of Colon Adenoma Synchronous to Carcinoma.
    Yun Yen; Fiscal Year: 2005
    ..We will understand better the biology of different subsets of sporadic CRC, namely CRC+SA, proximal tumors and MSI instable tumors. Our findings will impact on future clinical therapeutic studies of CRC. ..
  10. Role of non-tuberculous mycobacteria in lung disease
    Jason Stout; Fiscal Year: 2006
    ..Our findings will also assist clinicians in predicting which patients with NTM isolated from the respiratory tract will have NTM pulmonary disease. ..
  11. ANALGESIC REGIMENS FOR SURGERY AND INFLAMMATION IN MICE
    LINDA TOTH; Fiscal Year: 2006
    ..The data should reveal new and practical strategies for relief of post-procedural pain in mice. ..
  12. BEHAVIORAL AND PHYSIOLOGIC PATHOBIOLOGY OF MICE
    LINDA TOTH; Fiscal Year: 2006
    ..abstract_text> ..
  13. Mechanism of Action of G3139
    CY STEIN; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  14. EFFECTS OF STATINS ON PULMONARY HYPERTENSION
    Reda Girgis; Fiscal Year: 2007
    ..This award will allow the candidate to develop into a well-trained independent researcher in PH. ..
  15. Role of Matrix Metalloproteinase-2 in Liver Fibrosis
    Meena Bansal; Fiscal Year: 2007
    ..Findings from these investigations may lead to novel approaches to the treatment of chronic fibrosing liver disease. [unreadable] [unreadable]..
  16. NEUTROPHILS AND HEPATOTOXICITY
    ROBERT ANDREW ROTH; Fiscal Year: 2010
    ..Understanding how neutrophils interact with oxygen deficiency to promote liver injury could lead to better ways to prevent or treat adverse drug reactions and other types of inflammatory liver injury. ..
  17. Impact of Medicaid Policy on cardiovascular drug use and clinical outcomes
    Michael A Fischer; Fiscal Year: 2010
    ....
  18. The impact of early antiretroviral therapy on HIV persistence and inflammation
    STEVEN GRANT DEEKS; Fiscal Year: 2010
    ..Our work may also provide important insights in the role of chronic inflammation in driving viral persistence, and hence may lead to the development of novel interventions. ..
  19. Role of 15d-PGJ2 Hepatic Macrophages
    Cynthia Ju; Fiscal Year: 2005
    ..Furthermore, studies of inhibition of HO-1 and IL-10 will be carried out to determine functional association of 15d-PGJ2 with HO-1 and IL-10. ..
  20. The Role of RR in Chemotherapeutic Drug Resistance
    Yun Yen; Fiscal Year: 2005
    ..Taken together, our proposed studies will provide an integrated evaluation of the molecular control of RR-mediated chemotherapeutic drug resistance. ..
  21. NOVEL METHODS OF GENE THERAPY FOR LIVER DISEASE
    Timothy Davern; Fiscal Year: 2002
    ....
  22. DIETARY RESTRICTION AND TOXICANT-INDUCED LIVER DISEASE
    HARIHARA MEHENDALE; Fiscal Year: 2003
    ..The findings will shed light on the mechanisms of protection afforded by moderate DR against toxicity of environmental agents that have the potential to impact environmentally induced liver diseases. ..
  23. PHARMACOLOGY OF COMBINED EPHEDRINE/CAFFEINE SUPPLEMENTS
    Christine Haller; Fiscal Year: 2004
    ..The long-term objective for the proposed studies is to develop Dr. Haller into an independent career clinical researcher in this field of study. ..
  24. LIVER RESPONSE TO LPS--ROLE OF LBP AND CD14
    Grace Su; Fiscal Year: 2003
    ..II. Determine the mechanism by which LBP and CD14 accelerate ingestion of Gram-negative bacteria. III. Determine the mechanisms by which LBP/CD14 mediated KC activation promote bacterial killing. ..
  25. Immunologic Control of Drug-resistant HIV-1
    Steven Deeks; Fiscal Year: 2005
    ..Finally, since we will estimate the relative in vivo thresholds for HIV-mediated immunogenicity and pathogenicity, these studies may also have implications for vaccine development. ..
  26. Orthogonal Strategies for Specific Knockout Production
    CY STEIN; Fiscal Year: 2005
    ..Finally, in Specific Aim 4, we will evaluate the molecular consequences of the down regulation of bcl-2 and bcl-xL by employing the 12,000 gene-containing Affymetrix oligonucleotide microarray technology. ..
  27. Metabolism of Carcinogens and Drugs by Human P450s
    F Guengerich; Fiscal Year: 2005
    ..Successful completion of these collective studies should provide better understanding of the ways in which human P450s catalyze oxidation of carcinogens and drugs and the significance of variations in these enzymes. ..
  28. Treatment Intensification for Drug-Resistant HIV
    Steven Deeks; Fiscal Year: 2004
    ..Funding for the pilot clinical trial has been obtained from other sources; funding is requested in this proposal only for costs associated with the measurements of immunologic response to drug-resistant HIV-1. ..
  29. Role of O6-alkylguanine in nitrosamine-induced cancers
    Lisa Peterson; Fiscal Year: 2009
    ..These studies will set the stage for a molecular epidemiological study to determine whether individuals who are unable to repair this mutagenic adduct are at increased risk of tobacco-related cancers. ..
  30. Sleep and fatigue during renal disease in mice
    LINDA TOTH; Fiscal Year: 2008
    ..Achieving this ambitious goal is feasible given the experience of my laboratory in surveying sleep phenotypes in other studies involving large numbers of mice. [unreadable] [unreadable]..
  31. MOLECULAR STUDIES OF GENE TARGETED OLIGONUCLEOTIDES
    CY STEIN; Fiscal Year: 2002
    ..Finally, in Specific Aim 3, we will amplify the delivery of alt-OMPs and chi-OMPs to cells by condensing them with a novel delivery agent, tetra (N-methylpyridyl) porphine. ..
  32. SAMe Inhibits Inflammatory-mediated Enhanced Toxicity
    JANE MADDOX; Fiscal Year: 2003
    ..Moreover, they may provide evidence for development of related therapeutic compounds. ..
  33. Renal Failure in Non-Myeloablative Stem Cell Transplant
    Chirag Parikh; Fiscal Year: 2007
    ..abstract_text> ..
  34. IL-6 regulation of matrix degradation in liver fibrosis
    Meena Bansal; Fiscal Year: 2006
    ..Understanding these mechanisms will provide the basis for the development of novel anti-fibrotic therapies to treat a widely prevalent disease for which there is no effective treatment to date. ..
  35. Facility renovation to expand mouse barrier space
    LINDA TOTH; Fiscal Year: 2005
    ..This space will not be adequate to support our anticipated continued growth in the areas of infectious disease and toxic challenge and in the need for quarantine of non-vendor rodents. ..
  36. CO-CARCINOGENIC ACTIVITY OF NITROSAMINE METABOLITES
    Lisa Peterson; Fiscal Year: 2006
    ..In addition, this mechanism is likely applicable to other unsymmetric nitrosamines as well as carcinogenic mixtures such as tobacco smoke, a known human carcinogen. ..
  37. Eighth Cooley's Anemia Symposium
    Elliott Vichinsky; Fiscal Year: 2005
    ....
  38. Modulation of Iron Deposition in SCD and Other Hemoglobinopathies
    ELLIOTT P contact VICHINSKY; Fiscal Year: 2010
    ....
  39. E/BETA THALASSEMIA--NATURAL HISTORY & RESPONSE TO CHEMO
    Elliott Vichinsky; Fiscal Year: 2002
    ..In summary, if this study is successful, it will change the approach to Hb E/B worldwide and result in improved quality of life and decreased mortality. (End of Abstract) ..
  40. PI3K in LPS-induced coagulation and inflammation
    James Luyendyk; Fiscal Year: 2006
    ..Ultimately, characterization of the involvement of this pathway in LPS-induced inflammation may allow for development of novel strategies that can be used to treat sepsis. [unreadable] [unreadable] [unreadable]..
  41. Biochemical markers of bone turnover in metastatic prostate cancer
    Primo N Lara; Fiscal Year: 2010
    ....