Genomes and Genes
Summary: Manifestations of the adverse effects of drugs administered therapeutically or in the course of diagnostic techniques. It does not include accidental or intentional poisoning for which specific headings are available.
Publications333 found, 100 shown here
- Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patientsMunir Pirmohamed
Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool L69 3GE
BMJ 329:15-9. 2004..To ascertain the current burden of adverse drug reactions (ADRs) through a prospective analysis of all admissions to hospital...
- Systems pharmacology to predict drug toxicity: integration across levels of biological organizationJane P F Bai
Office of Clinical Pharmacology, Office of Translational Science, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland 20993, USA
Annu Rev Pharmacol Toxicol 53:451-73. 2013To achieve sensitive and specific mechanism-based prediction of drug toxicity, the tools of systems pharmacology will be integrated using structured ontological approaches, analytics, mathematics, and statistics...
- Data-driven methods to discover molecular determinants of serious adverse drug eventsA P Chiang
Department of Medicine, Stanford Center for Biomedical Informatics, Stanford University School of Medicine, Stanford, California, USA
Clin Pharmacol Ther 85:259-68. 2009..We also describe recent examples of how bioinformatics methods coupled with data repositories can advance the science of SADRs...
- Comorbidity and repeat admission to hospital for adverse drug reactions in older adults: retrospective cohort studyMin Zhang
School of Population Health, University of Western Australia, Perth, WA, Australia
BMJ 338:a2752. 2009..To identify factors that predict repeat admission to hospital for adverse drug reactions (ADRs) in older adults...
- Post-injection delirium/sedation syndrome in patients with schizophrenia treated with olanzapine long-acting injection, I: analysis of casesHolland C Detke
Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana, USA
BMC Psychiatry 10:43. 2010..During clinical trials, a post-injection syndrome characterized by signs of delirium and/or excessive sedation was identified in a small percentage of patients following injection with olanzapine LAI...
- Identifying and preventing adverse drug events in elderly hospitalised patients: a randomised trial of a program to reduce adverse drug effectsC Trivalle
Pole Vieillissement, Readaptation et Accompagnement, Hopital Paul Brousse, APHP, Villejuif, France
J Nutr Health Aging 14:57-61. 2010..Evaluate the impact of educational intervention in decreasing ADEs in elderly patients in a hospital setting...
- Adverse drug reaction deaths reported in United States vital statistics, 1999-2006Greene Shepherd
Eshelman School of Pharmacy, University of North Carolina, Asheville, USA
Ann Pharmacother 46:169-75. 2012..Adverse drug reactions (ADRs) are an important source of morbidity and mortality during medical care...
- Efficacy and safety of pegylated interferon combined with ribavirin for the treatment of older patients with chronic hepatitis CChung Feng Huang
Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
J Infect Dis 201:751-9. 2010..The present study evaluated the efficacy and safety of pegylated interferon (PegIFN)/ribavirin treatment in elderly patients with hepatitis C virus (HCV) infection...
- Cisplatin nephrotoxicityIstvan Arany
Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Semin Nephrol 23:460-4. 2003..Manipulation of these responses may be exploited to reduce its toxicity clinically...
- A randomized trial of electronic clinical reminders to improve medication laboratory monitoringMichael E Matheny
Division of General Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
J Am Med Inform Assoc 15:424-9. 2008..We evaluated the impact of electronic reminders delivered to primary care physicians on rates of appropriate routine medication laboratory monitoring...
- Effect of an electronic medication reconciliation application and process redesign on potential adverse drug events: a cluster-randomized trialJeffrey L Schnipper
Harvard Medical School, Division of General Medicine, Brigham and Women s Hospital, 1620 Tremont St, Boston, MA 02120 1613, USA
Arch Intern Med 169:771-80. 2009..We sought to measure the impact of an information technology-based medication reconciliation intervention on medication discrepancies with potential for harm (potential adverse drug events [PADEs])...
- A basic study design for expedited safety signal evaluation based on electronic healthcare dataSebastian Schneeweiss
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
Pharmacoepidemiol Drug Saf 19:858-68. 2010....
- The frequency of adverse drug reaction related admissions according to method of detection, admission urgency and medical department specialtyMiran Brvar
Poison Control Centre, University Medical Centre Ljubljana, Ljubljana, Slovenia
BMC Clin Pharmacol 9:8. 2009....
- Combining electronic healthcare databases in Europe to allow for large-scale drug safety monitoring: the EU-ADR ProjectPreciosa M Coloma
Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands
Pharmacoepidemiol Drug Saf 20:1-11. 2011..In this proof-of-concept paper we describe the framework, process, and preliminary results of combining data from European electronic healthcare record (EHR) databases for large-scale monitoring of drug safety...
- Harvesting candidate genes responsible for serious adverse drug reactions from a chemical-protein interactomeLun Yang
Bio X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai, China
PLoS Comput Biol 5:e1000441. 2009..In conclusion, SADR targets and the patient-specific off-targets could be identified through a systematic investigation of the CPI, generating important hypotheses for prospective experimental validation of the candidate genes...
- Strong association of a common dihydropyrimidine dehydrogenase gene polymorphism with fluoropyrimidine-related toxicity in cancer patientsEva Gross
Department of Gynecology, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
PLoS ONE 3:e4003. 2008..As known deleterious mutations explain only a limited proportion of the drug-adverse events, we systematically searched for additional DPYD variations associated with enhanced drug toxicity.
- A microfluidic 3D hepatocyte chip for drug toxicity testingYi Chin Toh
Institute of Bioengineering and Nanotechnology, A STAR, The Nanos, Singapore, 138669, Singapore
Lab Chip 9:2026-35. 2009We have developed a microfluidic 3D hepatocyte chip (3D HepaTox Chip) for in vitro drug toxicity testing to predict in vivo drug hepatotoxicity...
- Exploring off-targets and off-systems for adverse drug reactions via chemical-protein interactome--clozapine-induced agranulocytosis as a case studyLun Yang
Bio X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai, China
PLoS Comput Biol 7:e1002016. 2011....
- Renal vulnerability to drug toxicityMark A Perazella
Section of Nephrology, Department of Medicine, Yale University, New Haven, Connecticut 06520 8029, USA
Clin J Am Soc Nephrol 4:1275-83. 2009..Recognizing risk factors that increase renal vulnerability to drug-induced kidney disease is the first step in reducing the renal complications of drugs and toxins...
- microRNAs as mediators of drug toxicityTsuyoshi Yokoi
Department of Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa 920 1192, Japan
Annu Rev Pharmacol Toxicol 53:377-400. 2013....
- Prevalence of adverse events in pediatric intensive care units in the United StatesSwati Agarwal
Virginia Commonwealth University School of Medicine, Inova Campus, Pediatric Critical Care, Inova Fairfax Hospital for Children, Falls Church, VA, USA
Pediatr Crit Care Med 11:568-78. 2010....
- Post-injection delirium/sedation syndrome in patients with schizophrenia treated with olanzapine long-acting injection, II: investigations of mechanismDavid P McDonnell
Lilly Research Laboratories, Indianapolis, Indiana, USA
BMC Psychiatry 10:45. 2010..The authors conducted a series of parallel investigations into the possible reasons PDSS events occur...
- Post-approval drug safety surveillanceRobert D Gibbons
Center for Health Statistics, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Annu Rev Public Health 31:419-37. 2010..Many of these methodologies are then illustrated through application to data on the possible relationship between taking antidepressants and increased risk of suicidality...
- Prevalence of unplanned hospitalizations caused by adverse drug reactions in older veteransZachary A Marcum
Departments of Geriatrics, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15213, USA
J Am Geriatr Soc 60:34-41. 2012....
- FDA proposals to limit the hepatotoxicity of paracetamol (acetaminophen): are they reasonable?Garry G Graham
Department of Clinical Pharmacology, St Vincent s Hospital, Darlinghurst, NSW, 2010, Australia
Inflammopharmacology 18:47-55. 2010..Adoption of these two recommendations may lead to the increased use of NSAIDs with the potential of increasing incidence of NSAIDs-related adverse reactions...
- Review of pyronaridine anti-malarial properties and product characteristicsSimon L Croft
Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK
Malar J 11:270. 2012..falciparum malaria and blood stage P. vivax malaria with the name of Pyramax® and has received Positive Opinion by European Medicines Agency under the Article 58 procedure...
- Safety and immunogenicity of 2010-2011 H1N12009-containing trivalent inactivated influenza vaccine in children 12-59 months of age previously given AS03-adjuvanted H1N12009 pandemic vaccine: a PHAC/CIHR Influenza Research Network (PCIRN) studyJoanne M Langley
Canadian Center for Vaccinology, Dalhousie University and IWK Health Centre Halifax, Halifax, Nova Scotia, B3K 6R8, Canada
Vaccine 30:3389-94. 2012..We conducted a pre-season study of 2010-2011 TIV safety and immunogenicity in children 12-59 months of age to inform public health decision making...
- Adverse drug reactions related hospital admissions in persons aged 60 years and over, The Netherlands, 1981-2007: less rapid increase, different drugsKlaas A Hartholt
Section of Geriatric Medicine, Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
PLoS ONE 5:e13977. 2010..Because of raised awareness of ADR, a decrease in ADR might be expected. The aim of this study was to determine trends in ADR-related hospitalizations in the older Dutch population...
- Perceived adverse drug reactions among non-institutionalized children and adolescents in GermanyHildtraud Knopf
RKI 22, Robert Koch Institute, General Pape Strasse 64 66, 12101 Berlin, Germany
Br J Clin Pharmacol 70:409-17. 2010..7% to 2.7% among paediatric outpatients and from 2.6% to 18.1% among paediatric inpatients. Little has been reported on the risks of drug use in the general child population...
- Performance and safety of praziquantel for treatment of intestinal schistosomiasis in infants and preschool childrenJosé C Sousa-Figueiredo
Disease Control Strategy Group, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
PLoS Negl Trop Dis 6:e1864. 2012..We have formally assessed parasitological cure and putative side-effects in a prospective cohort of Schistosoma mansoni-infected children (aged 5 months-7 years old) in lakeshore settings of Uganda...
- Adverse drug reactions in patients in an Iranian department of internal medicineSara Pourseyed
Immunology, Asthma and Allergy Research Institute, Children Medical Center, Medical Sciences University of Tehran, Tehran, IR Iran
Pharmacoepidemiol Drug Saf 18:104-10. 2009..The department of internal medicine is not an exception to this issue. This study was performed to determine the nature and frequency of ADRs in an internal medicine ward in Iran...
- Drug toxicity in the neonateJohn McIntyre
Academic Division of Child Health, University of Nottingham, Derbyshire Children s Hospital, Derby, UK
Biol Neonate 86:218-21. 2004..This therefore predisposes to certain types of drug toxicity, which are described below...
- Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical eventsMarco Guerrini
Istituto di Ricerche Chimiche e Biochimiche G Ronzoni, Città Studi, via Giuseppe, Colombo 81, 20133 Milan, Italy
Nat Biotechnol 26:669-75. 2008..Our analysis suggests effective screening methods that can be used to determine whether or not heparin lots contain the contaminant reported here...
- Prospective drug safety monitoring using the UK primary-care General Practice Research Database: theoretical framework, feasibility analysis and extrapolation to future scenariosSaga Johansson
AstraZeneca R and D, Molndal, Sweden
Drug Saf 33:223-32. 2010..However, further improvement in drug safety monitoring requires a shift towards more proactive pharmacoepidemiological methods that can detect adverse drug signals as they occur in the population...
- Predicting drug side-effects by chemical systems biologyNicholas P Tatonetti
Training Program in Biomedical Informatics, Stanford University, Stanford, CA 94305, USA
Genome Biol 10:238. 2009..New approaches to predicting ligand similarity and protein interactions can explain unexpected observations of drug inefficacy or side-effects...
- Adverse drug events in hospitals: a systematic reviewFabíola Giordani Cano
Universidade Estadual do Oeste do Paraná, Cascavel, Brasil
Cad Saude Publica 25:S360-72. 2009..The findings show that ADEs in inpatients are a public health problem. However, further studies are needed to monitor these adverse events in order to effectively promote safe drug use...
- Safety, efficacy, and immunogenicity of an inactivated influenza vaccine in healthy adults: a randomized, placebo-controlled trial over two influenza seasonsLisa A Jackson
Group Health Research Institute, Seattle, Washington, USA
BMC Infect Dis 10:71. 2010..The aim of this study was to assess the efficacy, safety, reactogenicity, and immunogenicity of a trivalent inactivated split virion influenza vaccine (TIV) in healthy adults over two influenza seasons in the US...
- Incidence and preventability of adverse drug events among older persons in the ambulatory settingJerry H Gurwitz
Meyers Primary Care Institute and the University of Massachusetts Medical School, 630 Plantation St, Worcester, Mass 01605, USA
JAMA 289:1107-16. 2003..Adverse drug events, especially those that may be preventable, are among the most serious concerns about medication use in older persons cared for in the ambulatory clinical setting...
- Genome-wide association studies in pharmacogenomicsAnn K Daly
Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
Nat Rev Genet 11:241-6. 2010..Since 2007, a range of pharmacogenomics GWA studies have been published that have identified several interesting and novel associations between drug responses or reactions and clinically relevant loci, showing the value of this approach...
- Adverse drug event rates in six community hospitals and the potential impact of computerized physician order entry for preventionBalthasar L Hug
Division of General Internal Medicine, Brigham and Women s Hospital, Brigham Circle, 1620 Tremont St, 3rd Floor, Boston, MA, 02120 1613, USA
J Gen Intern Med 25:31-8. 2010..Medications represent a major cause of harm and are costly for hospitalized patients, but more is known about these issues in large academic hospitals than in smaller hospitals...
- Experience with a trigger tool for identifying adverse drug events among older adults in ambulatory primary careR Singh
Primary Care Research Institute, State University of New York at Buffalo, Buffalo, New York 14215, USA
Qual Saf Health Care 18:199-204. 2009..To evaluate the performance of a trigger tool for identifying adverse drug events (ADEs) among older adults in ambulatory primary care practices...
- Ten-year trends in hospital admissions for adverse drug reactions in England 1999-2009Tai Yin Wu
Department of Primary Care and Public Health, Imperial College London Charing Cross Campus, London W6 8RP, UK
J R Soc Med 103:239-50. 2010..Adverse drug reactions (ADR) are an important cause of morbidity and mortality. We analysed trends in hospital admissions associated with ADRs in English hospitals between 1999 and 2008...
- Adverse drug reactions in children--a systematic reviewRebecca Mary Diane Smyth
School of Nursing, Midwifery and Social Work, University of Manchester, Manchester, England, United Kingdom
PLoS ONE 7:e24061. 2012..We were particularly interested in understanding how ADRs might be better detected, assessed and avoided...
- The EU-ADR project: preliminary results and perspectiveGianluca Trifiro
Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands
Stud Health Technol Inform 148:43-9. 2009..The EU-ADR project aims to exploit different European electronic healthcare records (EHR) databases for drug safety signal detection. In this paper we describe the project framework and the preliminary results...
- Vaginal microbicides: detecting toxicities in vivo that paradoxically increase pathogen transmissionRichard A Cone
Mucosal Protection Laboratory, Dept of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA
BMC Infect Dis 6:90. 2006....
- Efficacy and safety of topical diclofenac containing dimethyl sulfoxide (DMSO) compared with those of topical placebo, DMSO vehicle and oral diclofenac for knee osteoarthritisLee S Simon
SDG LLC Consulting, 124 Mt Auburn Street, Cambridge, MA, USA
Pain 143:238-45. 2009..TDiclo in DMSO vehicle is an effective treatment option for knee osteoarthritis with efficacy similar to, but tolerability better than ODiclo. DMSO vehicle was no more efficacious than placebo...
- Zebrafish for drug toxicity screening: bridging the in vitro cell-based models and in vivo mammalian modelsHendrian Sukardi
National University of Singapore, Department of Biological Sciences, Singapore
Expert Opin Drug Metab Toxicol 7:579-89. 2011..A number of studies have been conducted to see if these small fish are up to the task of drug toxicity testing, an important rite of passage along the pharmaceutical pipeline.
- The challenge of predicting drug toxicity in silicoAngelo Vedani
Biographics Laboratory 3R, Friedensgasse 35, 4056 Basel, Switzerland
Basic Clin Pharmacol Toxicol 99:195-208. 2006....
- Evaluation of post-authorization safety studies in the first cohort of EU Risk Management Plans at time of regulatory approvalThijs J Giezen
Medicines Evaluation Board, The Hague, The Netherlands
Drug Saf 32:1175-87. 2009....
- [Adverse drug events in hospitalized elderly patients in a geriatric medicine unit: study of prevalence and risk factors]M Cecile
Service de médecine interne et gériatrie, centre hospitalier régional et universitaire de Marseille, Hopital Sainte Marguerite, 13327 Marseille cedex 9, France
Rev Med Interne 30:393-400. 2009..Our study compared the parameters of standard geriatric assessment, in the presence or absence of adverse drug events and evaluated the prevalence of adverse drug events in elderly inpatients, the symptoms, and the drugs involved...
- hERG-related drug toxicity and models for predicting hERG liability and QT prolongationEmanuel Raschi
University of Bologna, Department of Pharmacology, Italy
Expert Opin Drug Metab Toxicol 5:1005-21. 2009..Therefore, a number of preclinical models have been developed to predict hERG liability early in the drug development process...
- Risk factors associated with adverse drug reactions in hospitalised children: international multicentre studyAsia N Rashed
Centre for Paediatric Pharmacy Research, The School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
Eur J Clin Pharmacol 68:801-10. 2012..This study aimed to identify risk factors associated with ADRs in hospitalised children and recommend strategies to minimise ADRs...
- Identification of adverse drug events: the use of ICD-10 coded diagnoses in routine hospital dataJurgen Stausberg
Institut für Medizinische Informationsverarbeitung, Biometrie und Epidemiologie der LMU, Muchen, Germany
Dtsch Arztebl Int 107:23-9. 2010..The aim of this study is to examine the potential usefulness of ICD-10 coded diagnoses in routine hospital data for the identification of ADE...
- A drug toxicity death involving propylhexedrine and mitragynineJustin M Holler
Division of Forensic Toxicology, Armed Forces Medical Examiner System, Armed Forces Institute of Pathology, 1413 Research Blvd, Bldg 102, Rockville, Maryland, USA
J Anal Toxicol 35:54-9. 2011..This is the first known publication of a case report involving propylhexedrine and mitragynine...
- Cellular immunity as a potential cause of local reactions to booster vaccination with diphtheria and tetanus toxoids and acellular pertussis antigensDavid W Scheifele
Vaccine Evaluation Center, BC Children s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
Pediatr Infect Dis J 28:985-9. 2009..Cell-mediated immunity (CMI) develops after primary DTaP vaccination and might contribute to local reactions to booster doses, a possibility explored in this study...
- Pharmacogenomics and drug toxicityYusuke Nakamura
N Engl J Med 359:856-8. 2008
- The use of hepatocytes to investigate drug toxicityMaría José Gómez-Lechón
Unidad de Hepatologia Experimental, Centro de Investigacion, Hospital La Fe, Valencia, Spain
Methods Mol Biol 640:389-415. 2010..A convenient selection of endpoints allows a multiparametric evaluation of drug toxicity. In this regard, cytomic, proteomic, toxicogenomic and metabonomic approaches help to define patterns of ..
- A zone classification system for risk assessment of idiosyncratic drug toxicity using daily dose and covalent bindingShintaro Nakayama
Drug Metabolism and Pharmacokinetics Research Laboratories, R and D Division, Daiichi Sankyo Co, Ltd, 1 2 58, Hiromachi, Shinagawa ku, Tokyo, 140 8710, Japan
Drug Metab Dispos 37:1970-7. 2009The risk of idiosyncratic drug toxicity (IDT) is of great concern to the pharmaceutical industry. Current hypotheses based on retrospective studies suggest that the occurrence of IDT is related to covalent binding and daily dose...
- Inadequate statistical power to detect clinically significant differences in adverse event rates in randomized controlled trialsRuth Tsang
Vancouver General Hospital, Vancouver, British Columbia, Canada
J Clin Epidemiol 62:609-16. 2009..To determine the statistical power to detect potentially clinically significant differences in serious adverse events between drug therapies reported in a sample of randomized controlled trials (RCTs)...
- Hospital admissions for 'drug-induced' disorders in England: a study using the Hospital Episodes Statistics (HES) databasePatrick Waller
Drug Safety Research Unit, Southampton, UK
Br J Clin Pharmacol 59:213-9. 2005....
- Prediction and classification of drug toxicity using probabilistic modeling of temporal metabolic data: the consortium on metabonomic toxicology screening approachTimothy M D Ebbels
Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London, United Kingdom
J Proteome Res 6:4407-22. 2007Detection and classification of in vivo drug toxicity is an expensive and time-consuming process...
- Contribution of dihydropyrimidinase gene alterations to the development of serious toxicity in fluoropyrimidine-treated cancer patientsJulie Fidlerova
1st Faculty of Medicine, Institute of Biochemistry and Experimental Oncology, Charles University in Prague, U nemocnice 5, 128 53, Prague 2, Czech Republic
Cancer Chemother Pharmacol 65:661-9. 2010..The importance of gene variants in dihydropyrimidinase (DPYS) coding for subsequent catabolic enzyme of FP degradation is not fully understood...
- Epidemiology of recreational drug toxicity in a nightclub environmentDavid M Wood
Guy s and St Thomas Poisons Unit, Guy s and St Thomas NHS Foundation Trust, London, UK
Subst Use Misuse 44:1495-502. 2009Data on 173 individuals with recreational drug toxicity requiring "medical" assistance in a large urban nightclub was collected from September 2007 to January 2008...
- Improving the decision-making process in structural modification of drug candidates: reducing toxicityAlaa Eldin F Nassar
Vion Pharmaceuticals Inc, New Haven, CT, USA
Drug Discov Today 9:1055-64. 2004..Several examples are included to show how toxicity studies have influenced and guided drug design. Investigations of reactive intermediate formation in subcellular fractions with the use of radiolabeled reagents are also discussed...
- Mechanisms of drug toxicity and relevance to pharmaceutical developmentF Peter Guengerich
Department of Biochemistry and the Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, TN 37232 0146, USA
Drug Metab Pharmacokinet 26:3-14. 2011..The causes of drug toxicity can be classified in several ways and include mechanism-based (on-target) toxicity, immune hypersensitivity, ..
- Hydroxychloroquine and chloroquine retinopathy: screening for drug toxicityDavid J Browning
Charlotte Eye, Ear, Nose, and Throat Associates, Charlotte, North Carolina 28210, USA
Am J Ophthalmol 133:649-56. 2002To report hydroxychloroquine and chloroquine retinopathy and consider screening for drug toxicity.
- Adverse drug reactions detected by stimulated spontaneous reporting in an internal medicine department in RomaniaAndreea Farcas
University of Medicine and Pharmacy Iuliu Hatieganu, Drug Information Research Center, Pasteur 6, Cluj Napoca, Romania
Eur J Intern Med 21:453-7. 2010..The aims of this study were to identify the most frequent ADRs recognized by the attending physicians, study their nature and target these ADRs in order to take future preventive measures...
- Characterization of a gastrointestinal tract microscale cell culture analog used to predict drug toxicityGretchen J Mahler
School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York 14853, USA
Biotechnol Bioeng 104:193-205. 2009..The microCCA response is also consistent with in vivo measurements in mice. The system should be broadly useful for studies on orally delivered drugs or ingestion of chemicals with potential toxicity...
- Frequency and nature of adverse drug reactions in elderly in-patients of two Indian medical college hospitalsA Harugeri
Department of Pharmacy Practice, J S S College of Pharmacy and J S S Medical College Hospital, J S S University, Mysore, India
J Postgrad Med 57:189-95. 2011..Although the Indian elderly represent 12.8% of the entire global elderly population, data on prevalence and predictors of ADRs in elderly Indians is extremely limited...
- An observational efficacy and safety analysis of the treatment of acute invasive aspergillosis using voriconazoleF Jacobs
Hopital Erasme, Universite Libre de Bruxelles ULB, Brussels, Belgium
Eur J Clin Microbiol Infect Dis 31:1173-9. 2012..This observational study confirms the results of previous clinical trials demonstrating voriconazole as an effective and safe agent for treatment of confirmed acute IA...
- Adverse drug events in intensive care units: a cross-sectional study of prevalence and risk factorsSimon Seynaeve
Department of Critical Care Medicine, Antwerp University Hospital, University of Antwerp, Edegem, Belgium
Am J Crit Care 20:e131-40. 2011..Adverse drug events are considered determinants of patient safety and quality of care...
- Exploring QSARs with Extended Topochemical Atom (ETA) indices for modeling chemical and drug toxicityKunal Roy
Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India
Curr Pharm Des 16:2625-39. 2010..Such models may be used for virtual screening and in silico prediction of toxicities, and if appropriately used, these may be proved helpful for regulatory decision support and decision making processes...
- Dasatinib induces notable hematologic and cytogenetic responses in chronic-phase chronic myeloid leukemia after failure of imatinib therapyAndreas Hochhaus
III Medizinische Klinik, Medizinische Fakultat Mannheim, Universitat Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
Blood 109:2303-9. 2007..This trial was registered at www.clinicaltrials.gov as CA180013...
- Toxicophores: investigations in drug safetyDominic P Williams
Drug Safety Research Group, Department of Pharmacology and Therapeutics, University of Liverpool, Sherrington Building, Ashton Street, L69 3GE, United Kingdom
Toxicology 226:1-11. 2006..More importantly, to understand and manipulate these signalling processes will aid in the design of safer therapeutic agents, but also contribute to the clinical management of liver disease...
- Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromesGuillermo Garcia-Manero
Department of Leukemia, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Blood 111:1060-6. 2008..Increased histone acetylation was observed at all doses. Antioxidant gene expression may confer vorinostat resistance. Further evaluation of vorinostat in AML/MDS is warranted...
- Prevalence of adverse drug events in ambulatory care: a systematic reviewStephanie V Taché
Department of Family and Preventive Medicine, Paracelsus Medical University, Salzburg, Austria
Ann Pharmacother 45:977-89. 2011....
- Structural alert/reactive metabolite concept as applied in medicinal chemistry to mitigate the risk of idiosyncratic drug toxicity: a perspective based on the critical examination of trends in the top 200 drugs marketed in the United StatesAntonia F Stepan
Worldwide Medicinal Chemistry, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, USA
Chem Res Toxicol 24:1345-410. 2011..reactive metabolite (RM) formation with new drug candidates could mitigate the risk of idiosyncratic drug toxicity, the potential for RM formation is routinely examined as part of lead optimization efforts in drug discovery...
- Adverse drug events in U.S. adult ambulatory medical careUrmimala Sarkar
Department of Medicine, UCSF Center for Vulnerable Populations, San Francisco General Hospital Medical Services, Division of General Internal Medicine, University of California, San Francisco UCSF, Box 1364, 1001 Potrero, Bldg 10, 3rd Floor, San Francisco, CA 94143 1364, USA
Health Serv Res 46:1517-33. 2011..To estimate the incidence of adverse drug events (ADEs) associated with health care visits among U.S. adults across all ambulatory settings...
- Adaptive Bayesian analysis of serum creatinine as a marker for drug-induced renal impairment in an early-phase clinical trialPierre Edouard Sottas
Covance Central Laboratory Services, Meyrin, Switzerland
Clin Chem 58:1592-6. 2012..The design of a crossover drug protocol is an opportunity to use study participants as their own control to identify these small but important changes...
- Drug-related problems in hospitals: a review of the recent literatureAnita Krähenbühl-Melcher
Hospital Pharmacy, Regionalspital Emmental, Burgdorf, Switzerland
Drug Saf 30:379-407. 2007....
- Systematic review of the adverse effects of cutaneous leishmaniasis treatment in the New WorldLuiz F Oliveira
Instituto de Pesquisa Clinica Evandro Chagas, IPEC Fiocruz, Brazil
Acta Trop 118:87-96. 2011..Although closer surveillance is needed for the treatment of cutaneous leishmaniasis, antileishmanial drugs are basically safe and severe side effects requiring the discontinuation of treatment are relatively uncommon...
- [Adverse drug reactions as the reason for visiting an emergency department]Carlos Calderón-Ospina
Departamento de Ciencias Basicas, Facultad de Medicina, Universidad del Rosario, Bogota, Colombia
Rev Salud Publica (Bogota) 10:315-21. 2008..Determining the prevalence of adverse drug reactions (ADR) as the reason for visiting an emergency department...
- Off-label and unlicensed medication use and associated adverse drug events in a pediatric emergency departmentHanna Phan
Department of Pharmacy Practice and Science, University of Arizona, Tucson, AZ, USA
Pediatr Emerg Care 26:424-30. 2010....
- Focus on headache as an adverse reaction to drugsAnna Ferrari
Headache Centre, Division of Toxicology and Clinical Pharmacology, University Centre for Adaptive Disorders and Headache, Section Modena II University of Modena and Reggio Emilia, Policlinico, Modena 41100, Italy
J Headache Pain 10:235-9. 2009..Physicians should, therefore, be aware of this issue. Indeed, it is difficult to attribute the diagnosis of adverse drug reaction to a condition, headache, which is also a very common symptom in general population...
- Assessing the feasibility of using an adverse drug reaction preventability scale in clinical practice: a study in a French emergency departmentPascale Olivier
Department of Clinical Pharmacology, centre Midi Pyrénées de pharmacovigilance, Faculty of Medicine, Toulouse University Hospital, Toulouse, France
Drug Saf 25:1035-44. 2002..To assess the preventability of adverse drug reactions (ADRs) leading to hospital admissions and to investigate the feasibility of the use of a standardised preventability scale in clinical practice...
- Adverse drug reactions causing admission to a paediatric hospital: a pilot studyR M Gallagher
Institute of Child Health, Royal Liverpool Children s Hospital NHS Foundation Trust, University of Liverpool, Liverpool, UK
J Clin Pharm Ther 36:194-9. 2011..The objective of this study is to develop methodology to ascertain the current burden of ADRs through a prospective analysis of all unplanned admissions to a paediatric hospital...
- [Preventable adverse drug effects at an emergency department]M J Otero López
Servicio de Farmacia, Hospital Universitario de Salamanca
Rev Clin Esp 199:796-805. 1999..To determine the incidence and evaluate the preventability of adverse drug events (ADE) associated with visits to the Emergency Department at our hospital and subsequent hospital admissions...
- Diclofenac-induced liver injury: a paradigm of idiosyncratic drug toxicityUrs A Boelsterli
HepaTox Consulting, CH 4148 Pfeffingen, and Institute of Clinical Pharmacy, University of Basel, CH 4031 Basel, Switzerland
Toxicol Appl Pharmacol 192:307-22. 2003..Increased efforts to identify both patient-specific risk factors and disease-related factors will help to define patient subsets at risk as well as increase the predictability of unexpected hepatotoxicity in drug development...
- In vitro microscale systems for systematic drug toxicity studyJong Hwan Sung
Department of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, USA
Bioprocess Biosyst Eng 33:5-19. 2010..We envision that the 'cells-on-a-chip' technology will serve as a valuable link between in vitro and in vivo studies, reducing the demand for animal studies, and making clinical trials more effective...
- National surveillance of emergency department visits for outpatient adverse drug eventsDaniel S Budnitz
Division of Healthcare Quality Promotion, National Center for Infectious Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
JAMA 296:1858-66. 2006..Adverse drug events are common and often preventable causes of medical injuries. However, timely, nationally representative information on outpatient adverse drug events is limited...
- Predictors of survival and toxicity in patients on adjuvant therapy with 5-fluorouracil for colorectal cancerM Gusella
Laboratory of Pharmacology and Molecular Biology, Oncology Department, Azienda ULSS 18 Rovigo, Trecenta, Italy
Br J Cancer 100:1549-57. 2009..34; P=0.0008) and OS (HR=2.66; P=0.024); (d) the C/C genotype of the MTHFR C677T polymorphism was protective against grade 3-4 toxicity (P=0.040); (e) none of the TYMS polymorphisms could explain 5FU toxicity or clinical outcome...
- Polypharmacy in elderly patientsEmily R Hajjar
Philadelphia College of Pharmacy, University of the Sciences in Philadelphia, Philadelphia, Pennsylvania 15213, USA
Am J Geriatr Pharmacother 5:345-51. 2007..Polypharmacy (ie, the use of multiple medications and/or the administration of more medications than are clinically indicated, representing unnecessary drug use) is common among the elderly...
- SePreSA: a server for the prediction of populations susceptible to serious adverse drug reactions implementing the methodology of a chemical-protein interactomeLun Yang
Bio X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai 200030, PR China
Nucleic Acids Res 37:W406-12. 2009..The server is freely available at http://SePreSA.Bio-X.cn/...
- Improved therapeutic monitoring with several interventions: a randomized trialAdrianne C Feldstein
Center for Health Research, Kaiser Permanente, Portland, OR, USA
Arch Intern Med 166:1848-54. 2006..Differences between guideline recommendations and actual frequency of therapeutic laboratory monitoring are substantial. This study evaluated interventions to improve laboratory monitoring at initiation of medication therapy...
- Elucidating mechanisms of drug-induced toxicityDaniel C Liebler
Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, 638 Robinson Research Building, 23rd and Pierce Avenues, Nashville, Tennessee 37232 0146, USA
Nat Rev Drug Discov 4:410-20. 2005..Some of these pathways could be useful as sentinels for toxicity. This article will cover some examples of drug toxicity and the prospects for future technology development.
- Relationship between single nucleotide polymorphisms and haplotypes in DPYD and toxicity and efficacy of capecitabine in advanced colorectal cancerMaarten J Deenen
Division of Clinical Pharmacology, Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
Clin Cancer Res 17:3455-68. 2011..To explore the effect of dihydropyrimidine dehydrogenase (DPD) single nucleotide polymorphisms (SNP) and haplotypes on outcome of capecitabine...
- Predicting adverse drug reactions using publicly available PubChem BioAssay dataY Pouliot
Division of Systems Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA
Clin Pharmacol Ther 90:90-9. 2011..We conclude this paper by predicting that SOC-specific ADRs will be associated with three unapproved or recently introduced drugs...
- The effect of an active on-ward participation of hospital pharmacists in Internal Medicine teams on preventable Adverse Drug Events in elderly inpatients: protocol of the WINGS study (Ward-oriented pharmacy in newly admitted geriatric seniors)Joanna E Klopotowska
Department of Hospital Pharmacy, Academic Medical Centre, Amsterdam, The Netherlands
BMC Health Serv Res 11:124. 2011..Detailed information about the performance of the treating physicians in ADE recognition is scarce...
- SuperToxic: a comprehensive database of toxic compoundsUlrike Schmidt
Structural Bioinformatics Group, Institute of Molecular Biology and Bioinformatics, Charite University Medicine Berlin, Arnimallee 22, 14195 Berlin, Germany
Nucleic Acids Res 37:D295-9. 2009..This database is available online at: http://bioinformatics.charite.de/supertoxic...
- Metabonomics techniques and applications to pharmaceutical research & developmentJohn C Lindon
Biological Chemistry, Biomedical Sciences Division, Imperial College London, Sir Alexander Fleming Building, South Kensington, London, SW7 2AZ, UK
Pharm Res 23:1075-88. 2006..Some discussion is given on the strengths and weaknesses, opportunities of, and threats to metabonomics...
- Preventability of drug-related harms - part I: a systematic reviewRobin E Ferner
West Midlands Centre for Adverse Drug Reactions, City Hospital, Birmingham, UK
Drug Saf 33:985-94. 2010..We conclude that an approach based on analysis of the mechanisms of adverse reactions and their clinical features could be preferable; such an approach is described in a companion paper (Part II) in this issue of Drug Safety...
- STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGYKeri Hammel; Fiscal Year: 2013..Also, there will be a measurement of pressure in the eye and thickness of the cornea. To study patients'DNA, the researchers will obtain a bloo..
- STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGYKeri Hammel; Fiscal Year: 2012..Also, there will be a measurement of pressure in the eye and thickness of the cornea. To study patients'DNA, the researchers will obtain a bloo..
- Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical IllnessEva Szigethy; Fiscal Year: 2009..abstract_text> ..
- Prevention of Complications in ThalassemiaElliott P Vichinsky; Fiscal Year: 2011..Ourmissionalsoincludesmonitorinbgloodsafety amongtransfusion-dependtehnatlassemipaatientsa,ndprovidingoutreachand educationservicestoallat-riskpopulationtshroughoutht estate. ..
- SUPPORT CONTRACT FOR THE NTP INTERAGENCY CENTER/VALIDATION OF ALT METHODSDavid Allen; Fiscal Year: 2011..The Panel recommended that studies should be conducted to further characterize the in vitro test methods and that testing strategies should be designed in coordination with ICCVAM. ..
- SUPPORT CONTRACT FOR THE NTP INTERAGENCY CENTER/VALIDATION OF ALT METHODSDavid Allen; Fiscal Year: 2012..The Panel recommended that studies should be conducted to further characterize the in vitro test methods and that testing strategies should be designed in coordination with ICCVAM. ..
- Sutureless Laparoscopic Partial Nephrectomy Using Laser Tissue Welding: PreclinicYasmin Wadia; Fiscal Year: 2013..Fibro-optic capable: Minimally invasive laparoscopic &robotic applications. ..
- Xenoestrogen regulation of Leydig cellsBENSON TOKUNBO AKINGBEMI; Fiscal Year: 2010..Research training to be afforded by the present application to professional veterinary students will contribute to efforts geared to preparing future veterinarians to meet these challenges. ..
- Anti-tumor properties of curcumin in oral cancers: role of thioredoxin reductaseSTEPHEN WILLIAM TUTTLE; Fiscal Year: 2010..However, curcumin has been effective in tumors, such as colon and HNC, where direct access to the drug is possible. The primary aim of this study is to develop curcumin as a chemotherapeutic and radiation sensitizer for treating HNC.. ..
- Iron-mediated vascular disease in sickle cell disease.John C Wood; Fiscal Year: 2010..This proposal represents an essential first step in the design of a subsequent clinical trial to improve vascular function in SCD patients. ..
- Pilot and definitive studies to evaluate Insertional MutagenesisLU TAYLOR; Fiscal Year: 2012..abstract_text> ..
- Studies to Evaluate the Toxicological Potential of Test ArticlesLU TAYLOR; Fiscal Year: 2010..abstract_text> ..
- Multi-targeted Countermeasures against Acute and Delayed Effects of OP ExposureJohn A Butera; Fiscal Year: 2013..This would set the stage for a final lead optimization campaign focused on identifying pre- clinical leads with well-balanced in vivo PK parameters during an SBIR Phase 2 continuing grant. ..
- Enhanced iron removal with peptide linked chelators targeted to ferritinElizabeth C Theil; Fiscal Year: 2010....
- Peroxynitrite Decomposition Catalyst and Nitric Oxide Donor for EndotoxemiaGARRY JOHN SOUTHAN; Fiscal Year: 2012..We will now test this agent in a series of investigations in order to determine the optimal dose, to confirm the mechanism of action, and to establish the window of opportunity after disease onset within which therapy may be initiated. ..
- Pathogenesis and Treatment of Liver Disease in Transaldolase DeficiencyAndras Perl; Fiscal Year: 2013..These studies should generate fundamental new information on the cause and treatment of potentially fatal diseases of the liver. ..
- N-methanocarbathymidine (N-MCT) for the Treatment of Herpes and Pox Virus InfectiAquilur Rahman; Fiscal Year: 2010....
- Targeted siRNA nanotechnology for intravesical treatment of urologicaldiseasesRobert M Weiss; Fiscal Year: 2010..Our first test of these nanoparticles will use a mouse model of bladder cancer. Thus, we can determine the therapeutic potential of siRNA for treatment of urologic diseases. ..
- Investigating Mechanism of Intracellular Rotational Transport with Optical TJeffrey N Anker; Fiscal Year: 2012..Specifically, we measure toxicity of copper oxide and titanium dioxide which are widely used and have important ramifications for human health. ..
- A Soft Topical Antiandrogenic DrugWei Chu Xu; Fiscal Year: 2013..The synthesis and discovery of an optimal locally active androgen antagonist to be applied to the skin to treat acne, alopecia, seborrhea (and hirsutism in women) are the subjects of this application. ..
- SUPPORT CONTRACT FOR THE NTP INTERAGENCY CENTER/VALIDATION OF ALT METHODSDavid Allen; Fiscal Year: 2009..NICEATM and ICCVAM will also evaluate non-animal methods and approaches for determining the skin irritation potential of antimicrobial cleaning products...
- Trichothecene Toxicity and the Ribotoxic Stress ResponseJames J Pestka; Fiscal Year: 2012..Collectively, these outcomes will positively impact public health by providing a scientific basis for generating sound recommendations relative to these important toxins and appropriate remedial actions should exposures occur. ..
- Genistein, microRNAs and kidney cancerRajvir Dahiya; Fiscal Year: 2013..Since the goal of this proposal is to investigate the dietary mediated inhibition of RCC through activation of tumor suppressor miRNAs, we believe that the work proposed is highly relevant to Veterans health and the VA mission. ..
- Preclinical Development of JS-K, a Novel NO-Generating Prodrug for CancerPaul J Shami; Fiscal Year: 2012..This new drug then goes one step further: it will improve the quality of life for cancer patients, their caregivers and families by providing a significantly more effective and less painful therapy than is currently available. ..
- Nanoparticle Coupled Antioxidants for Respiratory Illness in VeteransRODNEY JON SCHLOSSER; Fiscal Year: 2013..We will use a murine model of allergic fungal rhinosinusitis with exacerbation by smoke or DEP exposure to determine the efficacy of antiMUC1-SOD/CAT-NPs. ..
- Controlling Radiation Injury by TLR5 AgonistsAndrei V Gudkov; Fiscal Year: 2012..The proposed experiments will provide essential mechanistic insight into the previously observed radio-protective and -mitigative effects of CBLB502. ..
- Novel PET imaging agents for early diagnosis of plaque deposition in Alzheimer'sPadmakar Kulkarni; Fiscal Year: 2010..A successful agent will be highly useful invention not only for early detection of but also for following disease progression and as biomarker for assessing disease-modifying treatments for Alzheimer's disease. ..
- Targeting superbugs: discovery and development of new broad-spectrum lipopeptidesJian Li; Fiscal Year: 2013..aeruginosa, A. baumannii and K. pneumoniae. Overall, this project targets the urgent global unmet medical need and responds in a timely manner to the recent global call for discovery of new antibiotics: The 10 x '20 Initiative. ..
- Comparison of Diesel and Biodiesel Emissions and Health Effects in Underground MiJefferey L Burgess; Fiscal Year: 2013..Information on the health effects of conversion to biodiesel fuels in occupational and environmental settings will also help to inform future policy decisions. ..
- SPEAKER TRAVEL AND SCIENTIFIC SESSION SUPPORT FOR THE TERATOLOGY SOCIETY 50TH Christina Chambers; Fiscal Year: 2011..Add Optional Project Narrative File Delete Optional Project Narrative File View Optional Project Narrative File !"#! ..
- Human neutrophils, phospholipase A2 and S.aureus: microbial targets and responsesWilliam M Nauseef; Fiscal Year: 2013..abstract_text> ..
- Bisphosphonates in the treatment of chronic kidney disease-mineral bone diseaseSharon M Moe; Fiscal Year: 2013..Both of these problems may be linked. The purpose of this study is to determine if a commonly used group of drugs, bisphosphonates, may help both bone and heart/blood vessel disease and determine the mechanism the drugs work. ..
- MOLECULAR MECHANISMS OF COMPLEX MIXTURE TOXICITYAlvaro Puga; Fiscal Year: 2013....
- Regulation of Cell Signaling by Human Biliverdin ReductaseMahin D Maines; Fiscal Year: 2013..In addition, the enzyme activity is necessary for protection against the fatal "green jaundice". Our work has revealed a novel approach for development of therapeutic interventions in a range of human diseases. ..
- Novel diagnostic and safety biomarkers of liver injury and hepatotoxicityStanislav I Svetlov; Fiscal Year: 2010..These assays will provide a novel diagnostic/prognostic tools and serve as "safety biomarkers." according to the FDA. ..
- Analysis of gene regulation of Vibrio cholerae during infectionJun Zhu; Fiscal Year: 2013..cholerae in vivo survival strategies and shed new light on the host-pathogen interactions that underpin infections by related enteric bacterial pathogens. ..
- Tissue-specific delivery of probes by control of membrane trafficking of endoprotBlake Peterson; Fiscal Year: 2010....
- C5a as an Anti-HIV Microbicidal CandidatePHILIPPE ANDRE GALLAY; Fiscal Year: 2013..In addition, protective results would provide proof-of-concept of the usefulness of topically applied microbicides, such as C5A, to prevent genital HIV transmission. ..
- Targeting CC-Chemokine Receptor 7 for the prevention of graft-versus-host diseaseJAMES M COGHILL; Fiscal Year: 2013..Through these experiences, Dr. Coghill will obtain the skills necessary to transition to an independent, NIH funded laboratory investigator. ..
- Emergency Neurophysiological Assessment Bedside Logic EngineDon M Tucker; Fiscal Year: 2010..g,. seizure, burst-suppression coma, drug toxicity, vasospasm, focal slowing due to hematoma)...
- Molecular mechanisms of lung disease in ataxia telangiectasiaJoAnn M Sekiguchi; Fiscal Year: 2013..abstract_text> ..
- Small Molecule targeting of NADPH oxidase in neutrophilsMarie Dominique Filippi; Fiscal Year: 2010..Therefore, our study will help delivering a novel pharmaceutical target, and suitable lead compounds for the treatment of lung inflammation, such as ALI and ARDS. ..
- Mechanism-Based Discovery of Protectants Against Iron-Dependant Oxidative InjuryJUSTIN M SCHWARTZ; Fiscal Year: 2011..My project proposes to better understand the role of iron mobilization from lysosomes to mitochondria in ischemia/reperfusion injury and to develop novel therapies to mitigate or eliminate damage from this condition. ..
- Arsenic Trioxide and Acute Myeloid LeukemiaYongkui Jing; Fiscal Year: 2012..Our goal will be to utilize As2O3 in combination with 4 HPR or EA analogs in clinical trials in patients with refractory, secondary or in elderly patients with acute myelogenous leukemia. ..
- Systemic AA Amyloidosis InhibitorsALAN D SNOW; Fiscal Year: 2010..In this project we intend to develop a new drug (and back-up) for effective treatment of ~100,000 cases of systemic amyloidosis in the USA, for which today there is no real treatment whatsoever. ..
- N-methanocarbathymidine (N-MCT) for the Treatment of Herpes and Pox Virus InfectiAquilur Rahman; Fiscal Year: 2013....
- Overcoming Temozolomide Resistance using MGMT-targeting Spherical Nucleic AcidsTIMOTHY L SITA; Fiscal Year: 2013..In vivo studies with orthotopic GBM mouse models will assess the combination treatment of MGMTi-SNAs and TMZ;we intend to (1) enhance intratumoral apoptosis, (2) reduce glioma formation, and (3) increase survival time. ..
- Nitric Oxide Restoration &Heme Detoxification as Adjunctive Therapies for CerebrLEONARDO JOSE DE MOURA CARVALHO; Fiscal Year: 2012..In this proposal, we intend to develop, using an animal model, adjunctive therapies based on nitric oxide restoration and/or heme detoxification that can be potentially translated into clinical use. ..
- Microsomal Cytochromes P450 and their Interactions with their Redox PartnersLucy A Waskell; Fiscal Year: 2013....
- Protection of Brain Injury from Cyanide Poisoning by Carnosic AcidStuart A Lipton; Fiscal Year: 2013..To investigate neuroprotective effects of CA in an in vitro model of cyanide poisoning. Specific Aim 2. To examine neuroprotective effects of CA in an in vivo mouse model mimicking the effects of cyanide ingestion. ..
- Transplatin: A Novel Agent to Mitigate Cisplatin ToxicityVickram Ramkumar; Fiscal Year: 2013..Overall, we believe that this study will provide the basis for the use of transplatin to alleviate cisplatin toxicities in cancer patients. ..
- NITROGEN HETEROCYCLES: METABOLIC EFFECTS AND TOXICITYRaymond F Novak; Fiscal Year: 2010....
- Predicting Bilirubin-induced Auditory Toxicity in Infants with Severe JaundiceSanjiv B Amin; Fiscal Year: 2010....
- Inhibiting Mucosal HIV-1 Transmission by Host Cell RNA InterferenceAlexandra L Howell; Fiscal Year: 2013..S. Veteran and active military population, and because of the increasing incidence of this disease in the U.S. ..
- Characterization of new toxins (YmgD and YdfD) from E.coli, targeting cell wallHisako Masuda; Fiscal Year: 2012....
- Preclinical drug trial in mouse models of inflammationKanneboyina Nagaraju; Fiscal Year: 2011..This proposal will help to train a pool of talented young scientists to pursue mouse model research and accelerate development of therapies for inflammatory diseases. ..
- CHEMISTRY AND BIOLOGY OF PLATINUM ANTICANCER DRUGSStephen J Lippard; Fiscal Year: 2013..The knowledge acquired will be used to design, synthesize, and evaluate new anticancer drug candidates for targeting and destroying tumors. ..
- Alcohol-Induced Bone Resorption: The Role of Oxidative StressMartin J J Ronis; Fiscal Year: 2013..In addition, in vivo studies will be conducted to examine the ability of antioxidants to block EtOH-induced bone resorption. ..
- Improved Adventitial Sirolimus Therapy for Peripheral Artery RestenosisKIRK SEWARD; Fiscal Year: 2010....
- Novel Zebrafish Models to Study Toxicity of PCBs and Pesticides During PregnancyLisa Satterwhite; Fiscal Year: 2009....
- The Electricidal Effect, a Novel Anti-Biofilm StrategyRobin Patel; Fiscal Year: 2013..This new strategy would overcome the resistance to traditional antibiotics of microorganisms in biofilms. ..
- Killed But Metabolically Active Leishmania: a novel protozoan vaccine technologyNoah Craft; Fiscal Year: 2009..If effective, this technology could potentially be applied to other infectious agents such as malaria and tuberculosis in the future. ..
- Depot calcineurin inhibitors to prevent graft rejectionThomas J Smith; Fiscal Year: 2010..In Phase 2 we propose to optimize the parameters of the delivery system, manufacture it according to FDA standards, and confirm its delivery profile and safety in further animal studies. ..
- Absorption, distribution, metabolism, excretion (ADME) of chemicals in mammalsRochelle W Tyl; Fiscal Year: 2009..N-dimethylacetoacetamide were completed during this reporting period and final reports are being prepared. ..
- Attenuating the retinal and CNS adverse effects of vigabatrin with NKCC1 inhibitoFrances E Jensen; Fiscal Year: 2010....
- Developing a prediction model for vincristine-induced peripheral neuropathyJamie L Renbarger; Fiscal Year: 2010..Once the correlation between genetics and vincristine neurotoxicity fully elucidated, it will be possible to individualize vincristine dosing using genetic information to optimize therapeutic efficacy while minimizing toxicity. ..
- FDG-PET and V/Q SPECT Acquired During Radiation to Predict Outcomes in Lung CanceFeng Ming Kong; Fiscal Year: 2009..If successful, future radiation therapy could be personalized based on their response to radiation and treatment gain could be maximized. ..
- CARDIAC & VASCULAR TOXICITY OF COCAINEJames Morgan; Fiscal Year: 1991..We anticipate that the results of these studies will not only clarify the pathophysiologic basis of cocaine's cardiovascular toxicity but will provide a rational basis for preventative measures and therapeutic interventions...
- Computational and Cell Culture Models for Mucus ClearanceRichard Superfine; Fiscal Year: 2010..The availability of a cell culture-based clearance assay coupled with an in- silico computational model will reduce the reliance on animal models and more accurately predict the consequences of toxins on human health. ..
- PHARMACOLOGY AND EFFICACY OF NOVEL TAXOL FORMULATIONSROBERT STRAUBINGER; Fiscal Year: 1999....
- Development of Transdermal Films for the the Delivery of HIV TherapeuticsAnthony Sang Won Ham; Fiscal Year: 2010..The research to be performed will include development of the transdermal film and the evaluation of its ability to deliver a therapeutic amount of IQP-0410 over long periods of time. ..
- GENOTOXICITY IN CYP1A2 DEFICIENT TRANSGENIC MICEDaniel Nebert; Fiscal Year: 2002..S. population. ..
- Molecular Regulation of Alpha-Synuclein Misfolding and Toxicity in Two Yeast ModeSHUBHIK DEBBURMAN; Fiscal Year: 2009....
- BILIRUBIN TOXICITY IN THE AUDITORY SYSTEMSteven Shapiro; Fiscal Year: 2005..The findings of the proposed research should lead to improved noninvasive procedures for predicting, preventing, and treating the neurological and audiological complications of bilirubin toxicity in human newborns. ..
- DOSIMETRY IN CHILDREN AND YOUNG ADULTS WITH NEUROBLASTOMA OR NEUROENDOCRINE TUMORM SUE O DORISIO; Fiscal Year: 2009..Our long-term goal is to develop patient specific, combination radiotherapy for pediatric tumors as a major step forward from the current approach of delivering an "average patient" radiation dose using a single agent. ..
- ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION (ADME) IN MAMMALSJacob McDonald; Fiscal Year: 2012..There is no ADME data in the literature for DMDEE. Therefore, the ADME of this is investigated in the current contract in rodents with special attention to the formation of carcinogenic metabolite N-nitrosomorpholine. ..
- Chromatin Modifications and Vulnerability to Glutamate ToxicityALEXEI D KONDRATYEV; Fiscal Year: 2010..This proposal will examine these mechanisms and will lay the foundation for identification of new targets for therapy of a broad variety of neurological conditions relevant to excitotoxicity. ..
- ANESTHETIC TOXICITY--MECHANISMS AND PREVENTIONEvan Kharasch; Fiscal Year: 1999..More importantly, potentially bioactivated anesthetics or protoxins may be rationally designed to avoid this metabolic hazard. ..