cadmium poisoning

Summary

Summary: Poisoning occurring after exposure to cadmium compounds or fumes. It may cause gastrointestinal syndromes, anemia, or pneumonitis.

Top Publications

  1. ncbi Reversal of cadmium induced oxidative stress by chelating agent, antioxidant or their combination in rat
    S K Tandon
    Chemical Toxicology, Industrial Toxicology Research Center, Post Box 80, Lucknow 226001, India
    Toxicol Lett 145:211-7. 2003
  2. ncbi [Cadmium]
    Masahiko Satoh
    Department of Hygienics, Gifu Pharmaceutical University
    Nihon Rinsho 62:334-8. 2004
  3. ncbi Plant science: the key to preventing slow cadmium poisoning
    Stephan Clemens
    Department of Plant Physiology, University of Bayreuth, 95440 Bayreuth, Germany
    Trends Plant Sci 18:92-9. 2013
  4. ncbi Cadmium toxicity revisited: focus on oxidative stress induction and interactions with zinc and magnesium
    Vesna Matovic
    Department of Toxicology Akademik Danilo Soldatović, Faculty of Pharmacy, University of Belgrade, Serbia
    Arh Hig Rada Toksikol 62:65-76. 2011
  5. ncbi Histopathological alterations in the edible snail, Babylonia areolata (spotted babylon), in acute and subchronic cadmium poisoning
    P Tanhan
    Department of Biology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
    Environ Toxicol 20:142-9. 2005
  6. ncbi Melatonin abrogates cadmium induced oxidative stress related neurotoxicity in rats
    K Shagirtha
    Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, India
    Eur Rev Med Pharmacol Sci 15:1039-50. 2011
  7. pmc Dietary cadmium exposure and prostate cancer incidence: a population-based prospective cohort study
    B Julin
    Unit of Nutritional Epidemiology, The Institute of Environmental Medicine, Karolinska Institutet, Box 210, 171 77 Stockholm, Sweden
    Br J Cancer 107:895-900. 2012
  8. ncbi Striking association between urinary cadmium level and albuminuria among Torres Strait Islander people with diabetes
    Melissa Haswell-Elkins
    North Queensland Health Equalities Promotion Unit, School of Medicine, University of Queensland, Cairns, QLD 4870, Australia
    Environ Res 106:379-83. 2008
  9. ncbi Serum vasoactive agents in rats poisoned with cadmium
    Helena Martynowicz
    Department of Internal Medicine, Occupational Diseases and Hypertension, Wrocław Medical University, Poland
    Int J Occup Med Environ Health 17:479-85. 2004
  10. ncbi [Acute and chronic cadmium poisoning]
    P Andujar
    INSERM, Unité 955, 94000 Creteil, France
    Rev Med Interne 31:107-15. 2010

Research Grants

  1. Annual SMRU Traveling Scholar Conference
    Susan Benoff; Fiscal Year: 2005
  2. Core Surveillance of Occupatiional Health in New York
    KITTY GELBERG; Fiscal Year: 2004
  3. MECHANISMS OF CADMIUM TOXICITY IN EPITHELIAL CELLS
    WALTER PROZIALECK; Fiscal Year: 2007
  4. INCREASED TESTICULAR CD2+ & INFERTILITY WITH VARICOCELE
    Susan Benoff; Fiscal Year: 2004
  5. HUMAN SPERM ZONA ACCEPTOR: ENVIRONMENTAL EFFECTS
    Susan Benoff; Fiscal Year: 2005
  6. Annual SMRU Traveling Scholars Conference
    Susan Benoff; Fiscal Year: 2006

Detail Information

Publications178 found, 100 shown here

  1. ncbi Reversal of cadmium induced oxidative stress by chelating agent, antioxidant or their combination in rat
    S K Tandon
    Chemical Toxicology, Industrial Toxicology Research Center, Post Box 80, Lucknow 226001, India
    Toxicol Lett 145:211-7. 2003
    ..The results suggest that the administration of an antioxidant during chelation of cadmium may provide beneficial effects by reducing oxidative stress without its cadmium removing ability...
  2. ncbi [Cadmium]
    Masahiko Satoh
    Department of Hygienics, Gifu Pharmaceutical University
    Nihon Rinsho 62:334-8. 2004
  3. ncbi Plant science: the key to preventing slow cadmium poisoning
    Stephan Clemens
    Department of Plant Physiology, University of Bayreuth, 95440 Bayreuth, Germany
    Trends Plant Sci 18:92-9. 2013
    ..The emerging molecular understanding of Cd uptake, root retention, root-to-shoot translocation and grain loading will enable the development of low Cd-accumulating crops...
  4. ncbi Cadmium toxicity revisited: focus on oxidative stress induction and interactions with zinc and magnesium
    Vesna Matovic
    Department of Toxicology Akademik Danilo Soldatović, Faculty of Pharmacy, University of Belgrade, Serbia
    Arh Hig Rada Toksikol 62:65-76. 2011
    ..At present, there is no clinically efficient agent to treat cadmium poisoning due to predominantly intracellular location of cadmium ions...
  5. ncbi Histopathological alterations in the edible snail, Babylonia areolata (spotted babylon), in acute and subchronic cadmium poisoning
    P Tanhan
    Department of Biology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
    Environ Toxicol 20:142-9. 2005
    ..The epithelial lining of the digestive tract showed similar alterations such as increased size of mucous vacuoles, reduced length of cilia, and dilation of nuclei. In addition, fragmentation of the muscle sheath was observed...
  6. ncbi Melatonin abrogates cadmium induced oxidative stress related neurotoxicity in rats
    K Shagirtha
    Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, India
    Eur Rev Med Pharmacol Sci 15:1039-50. 2011
    ....
  7. pmc Dietary cadmium exposure and prostate cancer incidence: a population-based prospective cohort study
    B Julin
    Unit of Nutritional Epidemiology, The Institute of Environmental Medicine, Karolinska Institutet, Box 210, 171 77 Stockholm, Sweden
    Br J Cancer 107:895-900. 2012
    ..Experimental data convincingly propose the toxic metal cadmium as a prostate carcinogen. Cadmium is widely dispersed into the environment and, consequently, food is contaminated...
  8. ncbi Striking association between urinary cadmium level and albuminuria among Torres Strait Islander people with diabetes
    Melissa Haswell-Elkins
    North Queensland Health Equalities Promotion Unit, School of Medicine, University of Queensland, Cairns, QLD 4870, Australia
    Environ Res 106:379-83. 2008
    ..This study explored associations between albuminuria and an index of cadmium exposure (urinary cadmium excretion) in the presence and absence of Type 2 diabetes...
  9. ncbi Serum vasoactive agents in rats poisoned with cadmium
    Helena Martynowicz
    Department of Internal Medicine, Occupational Diseases and Hypertension, Wrocław Medical University, Poland
    Int J Occup Med Environ Health 17:479-85. 2004
    ..The aim of this study was to evaluate the impact of subchronic Cd poisoning on blood nitric oxide or endothelin in blood and to relate it to the redox system activity in vessel walls and to blood Cd concentration...
  10. ncbi [Acute and chronic cadmium poisoning]
    P Andujar
    INSERM, Unité 955, 94000 Creteil, France
    Rev Med Interne 31:107-15. 2010
    ..According to literature, no chelating agent can be still used in human cadmium poisonings. In France, some diseases caused by occupational exposure to cadmium may be compensated...
  11. ncbi Renal organic cation transporters mediated cadmium-induced nephrotoxicity
    Sunhapas Soodvilai
    Department of Physiology, Faculty of Science, Mahidol University, Rama VI Road, Rajathevi, Bangkok, Thailand
    Toxicol Lett 204:38-42. 2011
    ..Taken together, this study provides for the first time, evidence showing OCT1 and OCT2 mediating cadmium transport across the basolateral membrane into the renal proximal tubular cells...
  12. ncbi The impact of subchronic cadmium poisoning on the vascular effect of nitric oxide in rats
    A Skoczynska
    Department of Internal Medicine, Occupational Diseases and Hypertension, Wroclaw Medical University, L Pasteur 4, Wroclaw, Poland
    Hum Exp Toxicol 24:353-61. 2005
    ..05) in both groups of cadmium-treated rats. These results suggest that cadmium in hypertensive doses modifies the vascular effect of NO in basal conditions and after stimulation by ACh...
  13. ncbi Captopril and telmisartan treatments attenuate cadmium-induced testicular toxicity in rats
    Amr A Fouad
    Department of Biomedical Sciences, Pharmacology Division, College of Medicine, King Faisal University, Al Ahsa, Saudi Arabia
    Fundam Clin Pharmacol 27:152-60. 2013
    ..The differences between the results obtained with captopril and telmisartan were insignificant, suggesting that both drugs equally protected the testicular tissue from the detrimental effects of cadmium...
  14. ncbi Effect of glutathione on the cadmium chelation of EDTA in a patient with cadmium intoxication
    Hyo Wook Gil
    Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, 23 20 Bongmyung dong, Cheonan City, South Korea
    Hum Exp Toxicol 30:79-83. 2011
    ..These results suggest that glutathione administration with EDTA might be an effective treatment modality for patients with cadmium intoxication...
  15. ncbi Relationship among prevalence of patients with Itai-itai disease, prevalence of abnormal urinary findings, and cadmium concentrations in rice of individual hamlets in the Jinzu River basin, Toyama prefecture of Japan
    Takeshi Ogawa
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Japan
    Int J Environ Health Res 14:243-52. 2004
    ..This study demonstrated that Itai-itai disease is induced by exposure to environmental Cd and that renal dysfunction plays an important role in its development...
  16. pmc Dietary cadmium and risk of invasive postmenopausal breast cancer in the VITAL cohort
    Scott V Adams
    Fred Hutchinson Cancer Research Center, Cancer Prevention Program, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Cancer Causes Control 23:845-54. 2012
    ..The aim of the study was to estimate the association between dietary intake of cadmium, a carcinogenic heavy metal, and risk of invasive postmenopausal breast cancer...
  17. ncbi Cadmium, osteoporosis and calcium metabolism
    George Kazantzis
    Department of Environmental Science and Technology, Imperial College London, UK
    Biometals 17:493-8. 2004
    ..The identification of cadmium, an environmental pollutant, as one causal factor is highly significant in helping to control the incidence of this complex condition...
  18. ncbi Cadmium therapeutic agents
    C Kelley
    Department of Chemistry, Northern Arizona University, Flagstaff, AZ 86011 5698
    Curr Pharm Des 5:229-40. 1999
    ..Preliminary attempts to combat acute cadmium poisoning included the use of the chelating agents ethylenediaminetetraacetic acid (EDTA) and British anti-Lewisite (..
  19. ncbi Low dose cadmium poisoning results in sustained ERK phosphorylation and caspase activation
    Patrick Martin
    Transcriptional Regulation and Differentiation, CNRS UMR 6548, Nice University, Parc Valrose, 06108 Nice Cedex 2, France
    Biochem Biophys Res Commun 350:803-7. 2006
    b>Cadmium poisoning has been known to result in a wide variety of cellular responses, including oxidative stress and kinase activation...
  20. ncbi Influence of drinking and/or cooking with Jinzu River water on the development of Itai-itai disease
    Etsuko Kobayashi
    Department of Occupational and Environmental Medicine A2, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuohku, Chiba, Japan
    Biol Trace Elem Res 129:46-57. 2009
    ....
  21. ncbi The vascular endothelium as a target of cadmium toxicity
    Walter C Prozialeck
    Department of Pharmacology, Midwestern University, 555 31st Street, Downers Grove, IL 60515, United States
    Life Sci 79:1493-506. 2006
    ..In addition the possible roles of the vascular endothelium in mediating the tumor promoting and anticarcinogenic effects of Cd are discussed...
  22. ncbi Mortality in a cadmium polluted area in Japan
    Muneko Nishijo
    Department of Public Health, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Biometals 17:535-8. 2004
    ....
  23. ncbi Male infertility and environmental exposure to lead and cadmium
    S Benoff
    Department of Obstetrics and Gynecology, North Shore University Hospital New York University School of Medicine, Manhasset 11032, USA
    Hum Reprod Update 6:107-21. 2000
    ..Reverse transcriptase-polymerase chain reaction assays for Ca2+ and K+ channel isoforms may identify susceptibility subgroups with lower resistance to environmental exposures...
  24. ncbi Influence of consumption of cadmium-polluted rice or Jinzu River water on occurrence of renal tubular dysfunction and/or Itai-itai disease
    Etsuko Kobayashi
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuohku, Chiba 260 8670, Japan
    Biol Trace Elem Res 127:257-68. 2009
    ....
  25. ncbi Cadmium exposure aggravates mortality more in women than in men
    Mirei Uetani
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan
    Int J Environ Health Res 16:273-9. 2006
    ..This study revealed that Cd exposure aggravates mortality more in women than in men...
  26. ncbi Acute cadmium chloride administration induces hepatic and renal CYP2A5 mRNA, protein and activity in the mouse: involvement of transcription factor NRF2
    A edah Abu-Bakar
    National Research Centre for Environmental Toxicology, University of Queensland, 39 Kessels Road, Coopers Plains, 4108 Qld, Brisbane, Australia
    Toxicol Lett 148:199-210. 2004
    ..Upregulation of CYP2A5 by cadmium in the Nrf2 +/+ mice but not in the Nrf2-/- mice indicates a role for this transcription factor in the regulation...
  27. ncbi Experimental reproduction of itai-itai disease, a chronic cadmium poisoning of humans, in rats and monkeys
    T Umemura
    Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    Jpn J Vet Res 48:15-28. 2000
    ....
  28. ncbi Potential for early involvement of CYP isoforms in aspects of human cadmium toxicity
    Jason R Baker
    National Research Center for Environmental Toxicology, University of Queensland, 39 Kessels Road, Coopers Plains, QLD 4108, Brisbane, Australia
    Toxicol Lett 137:85-93. 2003
    ..Potential mechanisms by which Cd may alter CYP4A11 expression are discussed briefly...
  29. ncbi [Concentration of cadmium in breast cancer tissue of women living in the Wielkopoiska region]
    Anna Rydzewska
    Pracownia Ochrony Srodowiska, Katedry Biologii i Ochrony Srodowiska, Akademia Medyczna im K Marcinkowskiego, Poznaniu
    Przegl Lek 61:786-8. 2004
    ..Moreover, marked differences were observed between the average cadmium concentrations in the breast cancer tissue samples in women living in the remaining voivodships and the types of living areas...
  30. ncbi Cadmium and health in the 21st century--historical remarks and trends for the future
    Gunnar F Nordberg
    Environmental Medicine, Department of Public Health and Clinical Medicine, Umea University, SE 90187 Umea, Sweden
    Biometals 17:485-9. 2004
    ..In many countries, Cd exposures are now under better control than in the past. The target for the 21st century is to achieve a totally acceptable exposure situation without adverse health effects from Cd...
  31. ncbi Influence of vitamin C on cadmium absorption and distribution in rats
    Andrzej Grosicki
    Laboratory of Radiological Protection and Isotopic Research, National Veterinary Research Institute, ul Partyzantow 57, 24 100 Pulawy, Poland
    J Trace Elem Med Biol 18:183-7. 2004
    ..In addition, the rats supplemented with vitamin C revealed an improved body weight gain during the experimental period...
  32. ncbi [The effects on bone of environmental cadmium exposure--summary of recent epidemiological studies]
    Ikiko Tsuritani
    Department of Hygiene, Kanazawa Medical University, Japan
    Clin Calcium 14:45-50. 2004
    ..The effect on bone could be caused indirectly through renal damage induced by cadmium exposure, or directly via an effect of cadmium on bone itself...
  33. ncbi Effect of environmental exposure to cadmium on pregnancy outcome and fetal growth: a study on healthy pregnant women in China
    Ya Li Zhang
    Department of Biology, Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin, China
    J Environ Sci Health A Tox Hazard Subst Environ Eng 39:2507-15. 2004
    ..24cm decrease in neonatal birth height. There was no significant association between cadmium exposure and birth weight. It was concluded that environmental exposure to cadmium significantly lower neonatal birth height...
  34. ncbi Cytotoxic mechanisms of Zn2+ and Cd2+ involve Na+/H+ exchanger (NHE) activation by ROS
    Sophia Koutsogiannaki
    Laboratory of Animal Physiology, Zoology Department, School of Biology, Faculty of Science, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
    Aquat Toxicol 78:315-24. 2006
    ..In addition, differences between the two metals concerning NHE activation, O2- production and interaction with adrenergic receptors were observed...
  35. ncbi Urinary excretion of cadmium among Torres Strait Islanders (Australia) at risk of elevated dietary exposure through traditional foods
    Melissa Haswell-Elkins
    North Queensland Health Equalities Promotion Unit, School of Population Health, University of Queensland, Cairns, Queensland, Australia
    J Expo Sci Environ Epidemiol 17:372-7. 2007
    ..This study highlights the need to consider social and cultural variation in exposure and to define "safe" cadmium levels during diabetes given its rising global prevalence...
  36. ncbi Tissue cadmium (Cd) concentrations of people living in a Cd polluted area, Japan
    Mirei Uetani
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chiba, 260 8670, Japan
    Biometals 19:521-5. 2006
    ....
  37. ncbi Trace mineral profile in blood and hair from cattle environmentally exposed to lead and cadmium around different industrial units
    R C Patra
    Environmental Medicine Laboratory, Division of Medicine, Indian Veterinary Research Institute, Izatnagar 243 122, UP, India
    J Vet Med A Physiol Pathol Clin Med 53:511-7. 2006
    ..385, 0.643) concentrations. Thus, it is concluded from the present study that the higher blood lead concentrations in cattle irrespective of locality/industrial operations areas affected trace elements profile in blood and hair...
  38. ncbi Anthropometric, environmental, and dietary predictors of elevated blood cadmium levels in Ukrainian children: Ukraine ELSPAC group
    Lee S Friedman
    Division of Environmental and Occupational Health Sciences, School of Public Health, University of Illinois, Chicago, IL, 60612, USA
    Environ Res 102:83-9. 2006
    ..Whole-blood cadmium levels observed in this group of Ukrainian children appear to be similar to those reported in other Eastern European countries...
  39. ncbi The effects of combined alpha-tocopherol, ascorbic acid, and selenium against cadmium toxicity in rat intestine
    Sehnaz Bolkent
    Department of Biology, Faculty of Science, Istanbul University, Vezneciler, Istanbul, Turkey
    J Environ Pathol Toxicol Oncol 26:21-7. 2007
    ..As a result, the combination of ascorbic acid, alpha-tocopherol, and selenium shows a protective effect against cadmium toxicity in small intestine...
  40. ncbi Renal dysfunction of cadmium-exposed workers residing in a cadmium-polluted environment
    Taiyi Jin
    Department of Occupational Health, School of Public Health, Fudan University 200032 Shanghai, PR China
    Biometals 17:513-8. 2004
    ..Furthermore, health examinations of this population should be conducted in time to prevent further health damage induced by cadmium exposure...
  41. ncbi Biochemical effects of lead, zinc, and cadmium from mining on fish in the Tri-States District of northeastern Oklahoma, USA
    Christopher J Schmitt
    U S Geological Survey, Columbia Environmental Research Center, 4200 New Haven Road, Columbia, Missouri 65201, USA
    Environ Toxicol Chem 24:1483-95. 2005
    ..Collectively, our results indicate that Pb is both bioavailable and active biochemically in the Spring-Neosho River system...
  42. ncbi The threshold cadmium level that causes a substantial increase in beta2-microglobulin in urine of general populations
    Masayuki Ikeda
    Kyoto Industrial Health Association, Kyoto, Japan
    Tohoku J Exp Med 205:247-61. 2005
    ..Thus, it is concluded that there is a threshold Cd-Ucr level that leads to a substantial increase in beta2-MG-Ucr, and that the threshold level is greater than 4 microg/g cr...
  43. ncbi Statement concerning the situation in the Wenzhou area
    Baochu Lin
    Wenzhou Anti Epidemic Station, Wenzhou, Zhejiang, PR China
    Biometals 17:595. 2004
  44. ncbi Markers of cadmium exposure in workers in a cadmium pigment factory after changes in the exposure conditions
    Takashi Kawasaki
    Department of Hygiene and Public Health, Osaka Medical College, Osaka, Japan
    Toxicol Ind Health 20:51-6. 2004
    ..Reversibility of urinary low molecular weight protein was observed in the workers over the four years...
  45. ncbi Importance of metallothioneins in the cadmium detoxification process in Daphnia magna
    B Fraysse
    Laboratoire d Eco toxicologie, EA 2069 URVVC, Faculte des Sciences, Université de Reims Champagne Ardenne Moulin de la Housse BP 1039, 51687 Reims Cedex2, France
    Comp Biochem Physiol C Toxicol Pharmacol 144:286-93. 2006
    ..Monitoring sub-cellular distribution of metals after exposure in the natural environment could be very useful for ecotoxicological assessment...
  46. ncbi Effect of the flavonoid quercetin on cadmium-induced hepatotoxicity
    C Vicente-Sánchez
    Instituto Reina Sofia de Investigacion Nefrologica, Departamento de Fisiologia y Farmacologia, Universidad de Salamanca, Spain
    Food Chem Toxicol 46:2279-87. 2008
    ..These results suggest that other mechanisms different to oxidative stress could be involved in hepatic damage...
  47. ncbi The potential role of combined anti-oxidants against cadmium toxicity on liver of rats
    Meral Koyuturk
    Department of Histology and Embryology, Faculty of Medicine, Istanbul Science University, 34394 Esentepe, Istanbul, Turkey
    Toxicol Ind Health 23:393-401. 2007
    ..As a result, these results suggest that combined anti-oxidants treatment might be useful in protection of liver against Cd toxicity...
  48. ncbi Estimation of cumulative cadmium intake causing Itai-itai disease
    Takeya Inaba
    Department of Occupational and Environmental Medicine, Graduate School of Medicine A2, Chiba University, Japan
    Toxicol Lett 159:192-201. 2005
    ..6 and 3.3 g, respectively. The present results clarify that Itai-itai disease, the most severe stage of chronic Cd poisoning, occurs at levels of Cd consumption amounting to approximately three-fold of those currently seen in Japan...
  49. ncbi Interactions between metabolism of trace metals and xenobiotic agonists of the aryl hydrocarbon receptor in the antarctic fish Trematomus bernacchii: environmental perspectives
    Francesco Regoli
    Istituto di Biologia e Genetica, Universita Politecnica delle Marche, Ancona, Italy
    Environ Toxicol Chem 24:1475-82. 2005
    ....
  50. ncbi Environmental epidemiological study and estimation of benchmark dose for renal dysfunction in a cadmium-polluted area in China
    Taiyi Jin
    Department of Occupational Health, School of Public Health, Fudan University, Shanghai, 200032 Shanghai, PR China
    Biometals 17:525-30. 2004
    ..This report is the first to use the BMD method in this field and to define the concept of critical concentration in urine...
  51. ncbi Renal dysfunction induced by cadmium: biomarkers of critical effects
    Alfred Bernard
    Catholic University of Louvain, 1200 Brussels, Belgium
    Biometals 17:519-23. 2004
    ..Cd-induced microproteinuria is usually considered as irreversible except at the incipient stage of the intoxication where a partial or complete reversibility has been found in some studies...
  52. ncbi Influence of cadmium and zinc on the mice resistance to Listeria monocytogenes infection
    Sandrita Simonyte
    Institute for Biomedical Research, Kaunas University of Medicine, 3007 Kaunas, Lithuania
    Medicina (Kaunas) 39:767-72. 2003
    ..The objective of this study was to examine the effect of chronic exposure to cadmium and zinc on the mice resistance to experimental Listeria monocytogenes infection...
  53. ncbi No clear-cut evidence for cadmium-induced renal tubular dysfunction among over 10,000 women in the Japanese general population: a nationwide large-scale survey
    T Ezaki
    Kyoto Industrial Health Association, 67 Nishinokyo Kitatsuboicho, Nakagyo ku, Kyoto 604 8472, Japan
    Int Arch Occup Environ Health 76:186-96. 2003
    ..To examine whether environmental exposure to cadmium has been inducing kidney dysfunction among middle-aged women in the general population in Japan...
  54. ncbi Determinants of cadmium burden levels in a population of children living in the vicinity of nonferrous smelters
    A Leroyer
    , Lille, 59037, France
    Environ Res 87:147-59. 2001
    ..14; 95% CI=[1.07-1.21] and x 1.25; 95% CI=[1.04-1.50]. Neither sex nor age was associated with CdB. Mean CdU was associated with paternal occupational cadmium exposure...
  55. ncbi Cadmium nephrotoxicity and evacuation from the body in a rat modeled subchronic intoxication
    Teiichiro Aoyagi
    Department of Urology, Ichikawa General Hospital, Tokyo Dental College, Ichikawa, Japan
    Int J Urol 10:332-8. 2003
    ..We studied Cd-induced subchronic nephrotoxicity and the cadmium evacuation system in rats and cultured human renal tubular cells...
  56. ncbi A retrospective study on the relation between renal dysfunction and cadmium concentration in rice in individual hamlets in the Jinzu River basin, Toyama Prefecture, Japan
    T Osawa
    Department of Hygiene, Chiba University School of Medicine, Chiba, 260-8670, Japan
    Environ Res 86:51-9. 2001
    ..The allowable values of Cd concentration in rice were estimated to be in the range of 0.05-0.20 ppm, representing values lower than the 0.4 ppm provisionally adopted by the Japanese government...
  57. ncbi Role of S-adenosyl-L-methionine in potentiating cadmium mobilization by diethylenetriamine penta acetic acid in mice
    U Gubrelay
    School of Studies in Zoology, Jiwaji University, Gwalior, India
    Cytobios 104:99-105. 2001
    ..The treatment with SAM alone was also effective in correcting the zinc and GSH concentrations. The results indicated few beneficial effects of concomitant SAM administration during chelation of cadmium with DTPA...
  58. ncbi [Biological function of some elements and their compounds. III. Zinc--component and activator of enzymes]
    Helena Puzanowska-Tarasiewicz
    Department of Chemistry Sciences, Higher School of Cosmetology and Protection of Health, Bialystok, Poland
    Pol Merkur Lekarski 27:419-22. 2009
    ..Zinc acts protectively in lead and cadmium poisoning and it participates in the elimination of free superoxide radicals (it inhibits of oxygenation of non-..
  59. ncbi Long-term extracellular signal-related kinase activation following cadmium intoxication is negatively regulated by a protein kinase C-dependent pathway affecting cadmium transport
    Patrick Martin
    CNRS FRE3094, Universite de Nice Sophia Antipolis, Nice, France
    FEBS J 276:1667-79. 2009
    ..Our results indicate that PKC activation negatively affects ZIP8 transporter activity, thus protecting cells against cadmium poisoning.
  60. ncbi Dimercaptosuccinic acid (DMSA), a non-toxic, water-soluble treatment for heavy metal toxicity
    A L Miller
    Alternative Medicine Review P O Box 25, Dover, ID 83825, USA
    Altern Med Rev 3:199-207. 1998
    ..Cases of severe acute lead, mercury, arsenic, and cadmium poisoning are rare; however, when they do occur an effective, non-toxic treatment is essential...
  61. ncbi Effect of cadmium-polluted water on plasma levels of tumor necrosis factor-α, interleukin-6 and oxidative status biomarkers in rats: protective effect of curcumin
    Abdullah Alghasham
    Department of Pharmacology and Therapeutics, College of Medicine, Qassim University, Saudi Arabia
    Food Chem Toxicol 59:160-4. 2013
    ..Negative correlation between IL-6 or TNF-α was and the plasma activities of catalase, SOD and the level of total antioxidant capacity were found in rats exposed to Cd...
  62. ncbi A global perspective on cadmium pollution and toxicity in non-occupationally exposed population
    Soisungwan Satarug
    National Research Centre for Environmental Toxicology, University of Queensland, 39 Kessels Road, Coopers Plains, QLD 4108, Brisbane, Australia
    Toxicol Lett 137:65-83. 2003
    ..Increased mortality was found among individuals showing signs of cadmium renal toxicity compared with those without such signs, suggesting that renal toxicity may be an early warning of complications, sub-clinical or clinical morbidity...
  63. ncbi Influence of time period of cadmium intoxication on the concentrations of ascorbic acid selenium in certain tissues and blood serum of rats
    Kazimierz Pasternak
    Department of General Chemistry, Medical University of Lublin
    Ann Univ Mariae Curie Sklodowska Med 57:132-7. 2002
    ..Furthermore, it has been demonstrated that ascorbic acid and selenium concentrations are dependent on the type of tissue tested as well as on the size of cadmium concentrations and length of the experiments...
  64. ncbi Pb and Cd poisoning during development alters cerebellar and striatal function in rats
    M Teresa Antonio
    Department of Animal Biology II, Faculty of Biology, Complutense University, 20840, Madrid, Spain
    Toxicology 176:59-66. 2002
    ..to examine more fully the neurochemical and behavioral interactions that derive from continued lead and cadmium poisoning in pups, whose mothers were exposed via drinking water (300 mg/l of Pb and 10 mg/l of Cd) throughout ..
  65. ncbi Effect of chronic administration of cadmium on the rat thyroid: radioimmunological and immunohistochemical studies
    B Piłat-Marcinkiewicz
    Department of Histology and Embryology, Medical Academy, Białystok, Poland
    Folia Histochem Cytobiol 40:189-90. 2002
    ..Serum T3 concentration was not affected by Cd, while T4 was reduced but only at the exposure to the higher Cd concentration. Moreover, the rats exposed to Cd showed a decrease in serum Ca concentration...
  66. ncbi Cadmium distribution and metallothionein expression in lizard tissues following acute and chronic cadmium intoxication
    Francesca Trinchella
    Dipartimento delle Scienze Biologiche Sezione di Biologia Evolutiva e Comparata, Universita Federico II, Via Mezzocannone 8, 80134 Napoli, Italy
    Comp Biochem Physiol C Toxicol Pharmacol 144:272-8. 2006
    ..Following a dietary cadmium treatment, a positive correlation between the increase of metallothionein mRNA and cadmium accumulation is found in intestine, ovary and kidney, while no correlation is present in liver and brain...
  67. ncbi The German Environmental Survey 1990/92 (GerES II): primary predictors of blood cadmium levels in adults
    K Hoffmann
    Institute for Water, Soil and Air Hygiene, Federal Environmental Agency, Berlin, Germany
    Arch Environ Health 56:374-9. 2001
    ..In this model, the effect of smoking was considered, and the model accounted for the biological half-life of cadmium in blood...
  68. ncbi Estimation of benchmark doses for urinary cadmium based on beta2-microglobulin excretion in cadmium-polluted regions of the Kakehashi River basin, Japan
    Akane Shimizu
    Department of Occupational and Environmental Medicine, Graduate School of Medicine A2, Chiba University, Chiba, Japan
    Int J Environ Health Res 16:329-37. 2006
    ....
  69. pmc Intravenous 1alpha, 25[OH]2 vitamin D3 (calcitriol) pulse therapy for bone lesions in a murine model of chronic cadmium toxicosis
    Y Kurata
    Toxicology Division, Mitsubishi Chemical Safety Institute Ltd, Ibaraki, Japan
    Int J Exp Pathol 82:43-53. 2001
    ..The findings indicated that the increased osteoid volume of the cortex and Fe-deposition volume of the trabecula were improved. These effects or improvements were observed in the sham-OVX rats but not in the OVX rats...
  70. ncbi Protective effects of glutathione and lipoic acid against cadmium-induced oxidative stress in rat's kidney
    Andrej R Veljkovic
    Faculty of Medicine, University of Nis, Nis, Serbia
    Ren Fail 34:1281-7. 2012
    ..The increased level of TBARS and the increased activity of XO in kidney tissue in cadmium poisoning are statistically significant compared to control (p < 0.001)...
  71. ncbi Association between cadmium concentration in rice and mortality in the Jinzu River basin, Japan
    T Ishihara
    Department of Hygiene, Chiba University School of Medicine, 1 8 1 Inohana, Chuohku, 260 8670, Chiba, Japan
    Toxicology 163:23-8. 2001
    ....
  72. ncbi Preliminary immunohistochemical study of C cells of the thyroid and endocrine cells of the parathyroid glands in rats after prolonged exposure to cadmium
    B Piłat-Marcinkiewicz
    Department of Histology and Embryology, Medical Academy, Białystok, Poland
    Folia Histochem Cytobiol 39:191-2. 2001
    ..The animals exposed to cadmium showed attenuation of all reactions, which was most distinct after 50 mg Cd/dm3. Exposure-dependent cadmium accumulation and a decrease in calcium concentration in the femoral bone were noted...
  73. ncbi [Exposure of the Berlin population to aromatic hydrocarbons and heavy metals within the scope of a study of the health effects of vehicular traffic]
    H Fromme
    Institut für Umweltanalytik und Humantoxikologie, Berlin
    Gesundheitswesen 59:512-8. 1997
    ..A statistical connection of benzene in blood to the indoor air concentration or the to the average daily traffic density could not be seen, but there is a relation to smoking habits...
  74. ncbi [Dosage of cadmium and lead in human blood by anodic stripping voltammetry]
    Tarik Attar
    Laboratoire d Electrochimie et Chimie Analytique, Departement de Chimie, Faculte des Sciences, Université Abou Bekr Belkaid, Tlemcen, Algerie
    Ann Biol Clin (Paris) 70:595-8. 2012
    ..The obtained limits of detection are equal to 0.46 and 0.08 ng/mL respectively for the lead and the cadmium. The developed method was validated by the analysis of reference materials certified by total blood...
  75. ncbi Changes in the structure and function of the kidney of rats chronically exposed to cadmium. II. Histoenzymatic studies
    Małgorzata M Brzóska
    Department of Toxicology, Medical University of Białystok, Mickiewicza 2c, 15 222 Białystok, Poland
    Arch Toxicol 78:226-31. 2004
    ..The results, together with observations reported in the first paper of the study, incline us to conclude that humans environmentally exposed to Cd are at risk of tubular damage...
  76. ncbi Chronic cadmium treatment induces islet B cell injury in ovariectomized cynomolgus monkeys
    Yoshimasa Kurata
    Laboratory of Comparative Pathology, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Jpn J Vet Res 50:175-83. 2003
    ..Therefore the islet B cell is one of the major targets of the chronic Cd poisoning in monkeys...
  77. ncbi Immunohistochemical and ultrastructural changes in the renal cortex of cadmium-treated rats
    Mevlut Asar
    Department of Histology and Embryology, Faculty of Medicine, University of Akdeniz, Antalya, Turkey
    Biol Trace Elem Res 97:249-63. 2004
    ..In conclusion, cadmium toxicity results in alterations in the renal extracellular matrix and tubular or glomerular cells, which could play an important role in renal dysfunction...
  78. ncbi Cadmium affects the social behaviour of rainbow trout, Oncorhynchus mykiss
    Katherine A Sloman
    Department of Biological Sciences, Brunel University, Uxbridge, Middlesex UB8 3PH, UK
    Aquat Toxicol 65:171-85. 2003
    ....
  79. ncbi The effects of a vitamin D-deficient diet on chronic cadmium exposure in rats
    Hideomi Uchida
    Kumamoto Laboratory, Toxicological Science Division, Medi Chem Business Segment, Mitsubishi Chemical Medience Corporation, Kumamoto 869 0425, Japan
    Toxicol Pathol 38:730-7. 2010
    ..The present experiment demonstrated that hypovitaminosis D did not evoke morphologic features of IID in humans but did enhance Cd-induced toxicity in the rat model of this disease...
  80. ncbi Synthesis and spectroscopic and structural studies of a new cadmium(II)-citrate aqueous complex. Potential relevance to cadmium(II)-citrate speciation and links to cadmium toxicity
    M Dakanali
    Department of Chemistry, University of Crete, Heraklion 71409, Greece
    Inorg Chem 42:2531-7. 2003
    ....
  81. ncbi Bias induced by the use of creatinine-corrected values in evaluation of beta2-microgloblin levels
    M Ikeda
    Kyoto Industrial Health Association, 67 Nishinokyo Kitatsuboicho, Nakagyo ku, 604 8472, Kyoto, Japan
    Toxicol Lett 145:197-207. 2003
    ....
  82. ncbi Changes in antioxidant status and biochemical parameters after orally cadmium administration in females rats
    S Chater
    Laboratoire de Physiologie Integree, Faculte des Sciences de Bizerte, 7021 Jarzouna, Tunisia
    Acta Biol Hung 60:79-88. 2009
    ..05). Results showed that cadmium given to dams led to an oxidative stress and DNA damage in tissues of pregnant rats...
  83. ncbi In utero exposure to cadmium pollution in Cairo and Giza governorates of Egypt
    G Mokhtar
    Department of Paediatrics, Ain Shams University, Cairo, Egypt
    East Mediterr Health J 8:254-60. 2002
    ..The cadmium levels did not differ between subjects from Cairo and Giza or according to urban, suburban or rural areas. Thus, in utero exposure to cadmium was evident and wider-scale studies on its long-term effects are recommended...
  84. ncbi Evaluation of metallothionein as a biomarker of single and combined Cd/Cu exposure in Dreissena polymorpha
    S Lecoeur
    UMR INRA DGER Métabolisme et Toxicologie Comparés des Xénobiotiques, Ecole NationaleVétérinaire de Lyon, 1, av Bourgelat, BP 83, F 69280 Marcy l Etoile, France
    Environ Res 94:184-91. 2004
    ..Our results suggest that the form of MT existing in D. polymorpha was not Cu-inducible. This could limit the use of MT in D. polymorpha as a biomarker of heavy metal pollution in freshwater ecosystems...
  85. ncbi Latest status of cadmium accumulation and its effects on kidneys, bone, and erythropoiesis in inhabitants of the formerly cadmium-polluted Jinzu River Basin in Toyama, Japan, after restoration of rice paddies
    Hyogo Horiguchi
    Division of Environmental Medicine, Center for Community Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi, 329 0498, Japan
    Int Arch Occup Environ Health 83:953-70. 2010
    ..The aim of this study is to investigate whether inhabitants there would still exhibit cadmium accumulation and its effects on kidneys, bones, and erythropoiesis...
  86. ncbi Attenuation of cadmium-induced necrotic cell death by necrostatin-1: potential necrostatin-1 acting sites
    Tzu Sheng Hsu
    Institute of Molecular and Cellular Biology and Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan
    Toxicol Appl Pharmacol 235:153-62. 2009
    ..Our study shows that, in addition to DR-mediated necrosis, Nec-1 is effective in attenuating Cd-induced necrosis. It rescues cells with reduced MMP implying that mitochondrion is its major acting site...
  87. ncbi Gut microbiota limits heavy metals burden caused by chronic oral exposure
    Jerome Breton
    Bactéries Lactiques and Immunité des Muqueuses, Centre d Infection et d Immunité de Lille, Institut Pasteur de Lille, INSERM U 1019, CNRS UMR 8204 Université Lille Nord de France, 1 rue du Pr Calmette, BP 245, F 59019 Lille, France
    Toxicol Lett 222:132-8. 2013
    ..Collectively, these data illustrate the complex host-microbes interplay occurring with environmental pollutants inside the gut. ..
  88. ncbi Protective effects of quercetin on cadmium-induced cytotoxicity in primary cultures of rat proximal tubular cells
    Lin Wang
    College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Taian 271018, Shandong, China
    Biomed Environ Sci 26:258-67. 2013
    ..To investigate the protective effects of quercetin on cadmium-induced cytotoxicity in primary cultures of rat proximal tubular (rPT) cells...
  89. ncbi The liver in itai-itai disease (chronic cadmium poisoning): pathological features and metallothionein expression
    Hayato Baba
    Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
    Mod Pathol 26:1228-34. 2013
    ..Prolonged exposure to low doses of Cd leads to high hepatic accumulation, which can then cause fibrosis; however, it also causes high expression of metallothionein, which is thought to reduce Cd hepatotoxicity...
  90. ncbi [Investigation of health status of workers exposed to low concentration cadmium in a zinc powder factory]
    Yu Lian Zhang
    Changsha Municipal Center for Disease Control and Prevention, Changsha 410001, China
    Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 29:936-8. 2011
    ..To explore the health status of workers exposed to Cd at low concentration...
  91. ncbi Effects of chronic cadmium poisoning on Zn, Cu, Fe, Ca, and metallothionein in liver and kidney of rats
    Ding Zhang
    College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, People s Republic of China
    Biol Trace Elem Res 149:57-63. 2012
    An experiment was conducted to invest effects of chronic cadmium poisoning on Zn, Cu, Fe, Ca, and metallothionein gene expression and protein synthesis in liver and kidney in rats...
  92. ncbi Prior cadmium exposure improves glucoregulation in diabetic rats but exacerbates effects on metabolic dysregulation, oxidative stress, and hepatic and renal toxicity
    Prem Kumar Singh
    Division of Metabolic Endocrinology, Department of Zoology, Faculty of Science, The M S University of Baroda, Vadodara 390002, Gujarat, India
    Drug Chem Toxicol 35:167-77. 2012
    ..Overall, the present results are novel and interesting to open more investigations on animal models of type 1 diabetes with a history of previous Cd exposure...
  93. ncbi [The effect of lead and cadmium on the lipid profile and psychosocial functioning of children with developmental disorders]
    Małgorzata Szkup-Jabłońska
    Samodzielna Pracownia Propedeutyki Pielegniarstwa Pomorskiego Uniwersytetu Medycznego w Szczecinie ul Zołnierska 48, 71 210 Szczecin
    Ann Acad Med Stetin 57:69-77. 2011
    ..The aim of this study was to examine the relationship between the concentration of lead, cadmium, and polyunsaturated fatty acids, and functioning of the child with developmental disorders...
  94. ncbi Bradykinin potentiating factor isolated from Buthus occitanus venom has a protective effect against cadmium-induced rat liver and kidney damage
    Souad H M Bekheet
    Zoology Department, Faculty of Science, Aswan, South Valley University, Egypt
    Tissue Cell 43:337-43. 2011
    ....
  95. ncbi Comparative effects of repeated administration of cadmium chloride during pregnancy and lactation and selenium protection against cadmium toxicity on some organs in immature rats' offsprings
    Souad H M Bekheet
    Zoology Department, Faculty of Science, South Valley University, Aswan, Egypt
    Biol Trace Elem Res 144:1008-23. 2011
    ....
  96. ncbi A polymorphism in metallothionein 1A (MT1A) is associated with cadmium-related excretion of urinary beta 2-microglobulin
    Lijian Lei
    Department of Occupational Health, School of Public Health, Fudan University, Shanghai, China
    Toxicol Appl Pharmacol 265:373-9. 2012
    ..In humans Cd is mainly bound to metallothioneins (MT), which scavenge its toxic effects. Here we analyzed whether polymorphisms in MT genes MT1A and MT2A influence Cd-related kidney damage...
  97. ncbi Oxidative damage in liver after perinatal intoxication with lead and/or cadmium
    Elvira Luján Massó
    Department of Animal Physiology II, Biology College, Complutense University of Madrid, Madrid, Spain
    J Trace Elem Med Biol 21:210-6. 2007
    ..Finally, simultaneous perinatal administration of both metals seems to protect, at least, in the liver TBARS production against the toxicity produced by Cd or Pb separately...
  98. ncbi Strong poison revisited
    Roger C Prince
    ExxonMobil Biomedical Sciences Inc, 1545 Route 22 East, Annandale, NJ 08801, USA
    J Inorg Biochem 101:1891-3. 2007
    ....
  99. ncbi Individual susceptibility to cadmium toxicity and metallothionein gene polymorphisms: with references to current status of occupational cadmium exposure
    Nobuhiko Miura
    National Institute of Occupational Safety and Health, 6 21 1 Nagao, Tama ku, Kawasaki 214 8585, Japan
    Ind Health 47:487-94. 2009
    ..This article describes the strategy method for analyzing individual susceptibility to cadmium toxicity and genetic polymorphisms of metallothionein, with reference to the current status of occupational cadmium exposure...
  100. ncbi [Effects of cadmium on testis function]
    Helena Martynowicz
    Katedry i Kliniki Chorób Wewnetrznych, Zawodowych i Nadciśnienia Tętniczego, Akademii Medycznej we Wrocławiu
    Med Pr 56:167-74. 2005
    ..Increasing environmental exposure to cadmium, currently existing occupational exposure and the prevalence of tobacco smoking results in constant increase in the number of diagnosed fertility impairments...
  101. ncbi Cadmium toxicity on arterioles vascular smooth muscle cells of spontaneously hypertensive rats
    BENNY WASHINGTON
    Department of Biological Sciences, Tennessee State University, Nashville, TN 37209, USA
    Int J Environ Res Public Health 3:323-8. 2006
    ..The present studies support the hypothesis that Cd can be a risk factor of hypertension through dysfunction of vascular smooth muscle cells under certain conditions...

Research Grants6

  1. Annual SMRU Traveling Scholar Conference
    Susan Benoff; Fiscal Year: 2005
    ..Without this exposure, many of them would have likely pursued different career paths. ..
  2. Core Surveillance of Occupatiional Health in New York
    KITTY GELBERG; Fiscal Year: 2004
    ..Health (BOH) has operated a Heavy Metals Registry for the reporting of cases of lead, mercury, arsenic, and cadmium poisoning, and an Occupational Lung Disease Registry for the reporting of cases of work related lung disease...
  3. MECHANISMS OF CADMIUM TOXICITY IN EPITHELIAL CELLS
    WALTER PROZIALECK; Fiscal Year: 2007
    ..Furthermore, the results of these studies could have more general implications regarding the mechanisms by which toxic substances affect living organisms. ..
  4. INCREASED TESTICULAR CD2+ & INFERTILITY WITH VARICOCELE
    Susan Benoff; Fiscal Year: 2004
    ..Controls will include fertile donors and fertile men with varicocele. ..
  5. HUMAN SPERM ZONA ACCEPTOR: ENVIRONMENTAL EFFECTS
    Susan Benoff; Fiscal Year: 2005
    ..Outcome is test of hypothesis, and possible mechanism explaining infertility associated with low sperm counts or idiopathic male infertility, tools for diagnosis, and hope for treatment. ..
  6. Annual SMRU Traveling Scholars Conference
    Susan Benoff; Fiscal Year: 2006
    ..Without this exposure, many of them would have likely pursued different career paths. [unreadable] [unreadable] [unreadable] [unreadable]..