poisoning

Summary

Summary: A condition or physical state produced by the ingestion, injection or inhalation of, or exposure to a deleterious agent.

Top Publications

  1. ncbi Ricin poisoning: a comprehensive review
    Jennifer Audi
    Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Environmental Hazards and Health Effects, Health Studies Branch, Emory University, USA
    JAMA 294:2342-51. 2005
  2. ncbi Failure of continuous venovenous hemofiltration to prevent death in paraquat poisoning
    Ja Ryong Koo
    Division of Nephrology, College of Medicine, Hallym University, Chunchon, Kangwon Do, Seoul, Korea
    Am J Kidney Dis 39:55-9. 2002
  3. ncbi Increasing deaths from opioid analgesics in the United States
    Leonard J Paulozzi
    Division of Unintentional Injury Prevention, National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Pharmacoepidemiol Drug Saf 15:618-27. 2006
  4. pmc Acetylcysteine for acetaminophen poisoning
    Kennon J Heard
    Rocky Mountain Poison and Drug Center, Denver Health, Denver 80208, USA
    N Engl J Med 359:285-92. 2008
  5. ncbi Poisoning due to pyrethroids
    Sally M Bradberry
    National Poisons Information Service Birmingham Centre, City Hospital, UK
    Toxicol Rev 24:93-106. 2005
  6. ncbi The population pharmacokinetics of citalopram after deliberate self-poisoning: a Bayesian approach
    Lena E Friberg
    School of Pharmacy, University of Queensland, Brishane, Australia
    J Pharmacokinet Pharmacodyn 32:571-605. 2005
  7. ncbi A systematic review of research examining benzodiazepine-related mortality
    Fiona Charlson
    National Drug and Alcohol Research Centre, University of New South Wales, Australia
    Pharmacoepidemiol Drug Saf 18:93-103. 2009
  8. pmc Self-poisoning in rural Sri Lanka: small-area variations in incidence
    Celie Manuel
    Department of International Health, Institute of International Health, Immunology and Microbiology, University of Copenhagen, Øster Farimagsgade 5, Building 16, P O Box 2099, 1014 Cph K, Denmark
    BMC Public Health 8:26. 2008
  9. ncbi Paraquat poisoning
    Chanchai Sittipunt
    Department of Internal Medicine, Chulalongkorn University School of Medicine, Bangkok, Thailand
    Respir Care 50:383-5. 2005
  10. ncbi Deliberate self-harm/poisoning, suicide trends. The link to increased alcohol consumption in Sri Lanka
    Neil R M Jayasinghe
    R and D Office, Broomfield Hospital, Court Road, Chelmsford, Essex, UK
    Arch Suicide Res 15:223-37. 2011

Detail Information

Publications354 found, 100 shown here

  1. ncbi Ricin poisoning: a comprehensive review
    Jennifer Audi
    Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Environmental Hazards and Health Effects, Health Studies Branch, Emory University, USA
    JAMA 294:2342-51. 2005
    ..Ricin is one of the most potent and lethal substances known, particularly when inhaled. The ease with which the native plant (Ricinus communis) can be obtained and the toxin extracted makes ricin an attractive weapon...
  2. ncbi Failure of continuous venovenous hemofiltration to prevent death in paraquat poisoning
    Ja Ryong Koo
    Division of Nephrology, College of Medicine, Hallym University, Chunchon, Kangwon Do, Seoul, Korea
    Am J Kidney Dis 39:55-9. 2002
    Paraquat poisoning is characterized by multiorgan failure and pulmonary fibrosis with respiratory failure. Multiorgan failure with circulatory collapse is a major cause of early death within 3 days of paraquat ingestion...
  3. ncbi Increasing deaths from opioid analgesics in the United States
    Leonard J Paulozzi
    Division of Unintentional Injury Prevention, National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Pharmacoepidemiol Drug Saf 15:618-27. 2006
    Since 1990, numerous jurisdictions in the United States (US) have reported increases in drug poisoning mortality. During the same time period, the use of opioid analgesics has increased markedly as part of more aggressive pain management...
  4. pmc Acetylcysteine for acetaminophen poisoning
    Kennon J Heard
    Rocky Mountain Poison and Drug Center, Denver Health, Denver 80208, USA
    N Engl J Med 359:285-92. 2008
  5. ncbi Poisoning due to pyrethroids
    Sally M Bradberry
    National Poisons Information Service Birmingham Centre, City Hospital, UK
    Toxicol Rev 24:93-106. 2005
    ..through voltage-dependent chloride channels and this action probably contributes the most to the features of poisoning with type II pyrethroids...
  6. ncbi The population pharmacokinetics of citalopram after deliberate self-poisoning: a Bayesian approach
    Lena E Friberg
    School of Pharmacy, University of Queensland, Brishane, Australia
    J Pharmacokinet Pharmacodyn 32:571-605. 2005
    Defining the pharmacokinetics of drugs in overdose is complicated. Deliberate self-poisoning is generally impulsive and associated with poor accuracy in dose history...
  7. ncbi A systematic review of research examining benzodiazepine-related mortality
    Fiona Charlson
    National Drug and Alcohol Research Centre, University of New South Wales, Australia
    Pharmacoepidemiol Drug Saf 18:93-103. 2009
    ..This paper will review literature examining the association of benzodiazepine use and mortality...
  8. pmc Self-poisoning in rural Sri Lanka: small-area variations in incidence
    Celie Manuel
    Department of International Health, Institute of International Health, Immunology and Microbiology, University of Copenhagen, Øster Farimagsgade 5, Building 16, P O Box 2099, 1014 Cph K, Denmark
    BMC Public Health 8:26. 2008
    Self-poisoning is one of the most common methods of suicide worldwide...
  9. ncbi Paraquat poisoning
    Chanchai Sittipunt
    Department of Internal Medicine, Chulalongkorn University School of Medicine, Bangkok, Thailand
    Respir Care 50:383-5. 2005
  10. ncbi Deliberate self-harm/poisoning, suicide trends. The link to increased alcohol consumption in Sri Lanka
    Neil R M Jayasinghe
    R and D Office, Broomfield Hospital, Court Road, Chelmsford, Essex, UK
    Arch Suicide Res 15:223-37. 2011
    ..The authors conclude that there is a strong association between alcohol consumption and suicide/poisoning/deliberate self-harm in Sri Lanka and propose a number of research priorities.
  11. pmc Changing epidemiologic patterns of deliberate self poisoning in a rural district of Sri Lanka
    Lalith Senarathna
    South Asian Clinical Toxicology Research Collaboration, University of Peradeniya, Peradeniya, Sri Lanka
    BMC Public Health 12:593. 2012
    Acute poisoning is a major public health issue in many parts of the world. The epidemiology and the mortality rate is higher in low and middle income countries, including Sri Lanka...
  12. ncbi Risk factors for acute pesticide poisoning in Sri Lanka
    Wim van der Hoek
    International Water Management Institute, Colombo, Sri Lanka
    Trop Med Int Health 10:589-96. 2005
    This report describes the characteristics of patients with acute pesticide poisoning in a rural area of Sri Lanka and, for intentional self-poisoning cases, explores the relative importance of the different determinants...
  13. pmc A community-based cluster randomised trial of safe storage to reduce pesticide self-poisoning in rural Sri Lanka: study protocol
    Melissa Pearson
    Clinical Pharmacology Unit, University of Edinburgh, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    BMC Public Health 11:879. 2011
    The WHO recognises pesticide poisoning to be the single most important means of suicide globally...
  14. ncbi Influence of sociodemographic factors on the risk of unintentional childhood home injuries
    Bjarne Laursen
    National Institute of Public Health, University of Southern Denmark, Øster Farimagsgade 5 A, 2, DK 1399 Copenhagen K, Denmark
    Eur J Public Health 18:366-70. 2008
    ..The purpose of the study was to reveal how sociodemographic factors affect the incidence of unintentional home injuries in Danish children for specific injury mechanisms and involved products...
  15. pmc Postcards from the EDge project: randomised controlled trial of an intervention using postcards to reduce repetition of hospital treated deliberate self poisoning
    Gregory L Carter
    Suicide Prevention Research Unit, Centre for Mental Health Studies, Faculty of Health, University of Newcastle, Newcastle, Australia
    BMJ 331:805. 2005
    To determine whether an intervention using postcards (postcards from the EDge project) reduces repetitions of hospital treated deliberate self poisoning.
  16. pmc Epidemiology of intentional self-poisoning in rural Sri Lanka
    Michael Eddleston
    Department of Clinical Medicine, Faculty of Medicine, PO Box 271, 25 Kynsey Road, Colombo 8, Sri Lanka
    Br J Psychiatry 187:583-4. 2005
    We investigated the epidemiology of intentional self-poisoning in rural Sri Lanka by prospectively recording 2189 admissions to two secondary hospitals. Many patients were young (median age 25 years), male (57%) and used pesticides (49%)...
  17. pmc Acute human lethal toxicity of agricultural pesticides: a prospective cohort study
    Andrew H Dawson
    South Asian Clinical Toxicology Research Collaboration, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka
    PLoS Med 7:e1000357. 2010
    agricultural pesticide poisoning is a major public health problem in the developing world, killing at least 250,000-370,000 people each year...
  18. ncbi Organophosphates/nerve agent poisoning: mechanism of action, diagnosis, prophylaxis, and treatment
    Jiri Bajgar
    Purkyne Military Medical Academy, Hradec Kralove, Czech Republic
    Adv Clin Chem 38:151-216. 2004
    ..The diagnosis of OP/nerve agent poisoning is based on anamnesis, the clinical status of the intoxicated organism, and on cholinesterase determination in ..
  19. ncbi Acute poisonings treated in hospitals in Oslo: a one-year prospective study (I): pattern of poisoning
    K E Hovda
    Department of Acute Medicine, Ullevaal University Hospital, Oslo, Norway
    Clin Toxicol (Phila) 46:35-41. 2008
    Prospective design is mandatory to study pattern of poisoning and suicidal intention of patients.
  20. ncbi 2004 Annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System
    William A Watson
    American Association of Poison Control Centers, 3201 New Mexico Avenue, Ste 330, Washington, DC 20016, USA
    Am J Emerg Med 23:589-666. 2005
  21. pmc Suicide acts in 8 states: incidence and case fatality rates by demographics and method
    R S Spicer
    Pacific Institute for Research and Evaluation, Landover, MD 20785, USA
    Am J Public Health 90:1885-91. 2000
    ..This study examined incidence rates of medically identified suicide acts (self-inflicted injuries, either fatal or nonfatal) and case fatality rates by age, sex, race, and method used...
  22. pmc Characteristics of non-fatal self-poisoning in Sri Lanka: a systematic review
    Thilini Rajapakse
    Department of Psychiatry, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka
    BMC Public Health 13:331. 2013
    The rate of non-fatal self-poisoning in Sri Lanka has increased in recent years, with associated morbidity and economic cost to the country...
  23. ncbi Mitochondria and sulfide: a very old story of poisoning, feeding, and signaling?
    Frederic Bouillaud
    Institut Cochin, Universite Paris Descartes, Inserm U1016, CNRS UMR8104, Paris, France
    Antioxid Redox Signal 15:379-91. 2011
    ..Finally, we offer perspectives for future studies on the relationship between the two opposing aspects of this Janus-type molecule, sulfide...
  24. ncbi Deliberate self-harm in adolescents: a study of characteristics and trends in Oxford, 1990-2000
    Keith Hawton
    Centre for Suicide Research, University of Oxford Department of Psychiatry, Warneford Hospital, Headington, Oxford, UK
    J Child Psychol Psychiatry 44:1191-8. 2003
    ..Deliberate self-harm (DSH) is a major healthcare problem in adolescents. Identification of targets for prevention and treatment requires ongoing monitoring of trends and characteristics of those involved...
  25. ncbi New roles for poison control centres in the developing countries
    Amalia Laborde
    Centro de Información y Asesoramiento Toxicológico, Department of Toxicology, Faculty of Medicine, Hospital de Clinicas, Av Italia s n P7, Montevideo, Uruguay
    Toxicology 198:273-7. 2004
    ..g., lead contamination (children), children 'occupational' poisoning, and flour contamination with fusarium toxins...
  26. ncbi Formate kinetics in methanol poisoning
    P Hantson
    Department of Intensive Care, Cliniques St Luc, Universite Catholique de Louvain, Brussels, Belgium
    Hum Exp Toxicol 24:55-9. 2005
    The objective is to describe the kinetics of formate, the main toxic metabolite of methanol, in a series of consecutive patients treated in the same intensive care unit for severe methanol poisoning.
  27. ncbi American Academy of Clinical Toxicology practice guidelines on the treatment of methanol poisoning
    Donald G Barceloux
    American Academy of Clinical Toxicology, Harrisburg, Pennsylvania 17105 8820, USA
    J Toxicol Clin Toxicol 40:415-46. 2002
    Almost all cases of acute methanol toxicity result from ingestion, though rarely cases of poisoning have followed inhalation or dermal absorption...
  28. ncbi Epidemiological trends of suicide and attempted suicide by poisoning in the US: 2000-2008
    Henry A Spiller
    Kentucky Regional Poison Control Center, Louisville, KY, USA
    Leg Med (Tokyo) 12:177-83. 2010
    ..The purpose of this study was to examine trends in suspected suicide (SS) cases reported to the National Poison Data System (NPDS), over a 9-year period (2000-2008)...
  29. ncbi Self-poisoning suicide attempts among students in Tehran, Iran
    Esmail Farzaneh
    Department of Medical Toxicology and Forensic Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
    Psychiatr Danub 22:34-8. 2010
    This study aim was to describe the epidemiology of intentional self-poisoning among students.
  30. pmc Post-exposure targeting of specific epitopes on ricin toxin abrogates toxin-induced hypoglycemia, hepatic injury, and lethality in a mouse model
    James K Roche
    Division of Nephrology, Department of Medicine, University of Virginia Health Sciences Center, Charlottesville, VA, USA
    Lab Invest 88:1178-91. 2008
    ..These data identify critical events for liver injury and healing in ricin intoxication, as well as a new means and specific targets for post-exposure therapeutic intervention...
  31. ncbi The effectiveness of combined treatment with methylprednisolone and cyclophosphamide in oral paraquat poisoning
    Saeed Afzali
    Poisoning Ward, Sina Hospital, Hamadan, Iran
    Arch Iran Med 11:387-91. 2008
    ..So, this study was designed to evaluate the effects of combined treatment with cyclophosphamide and glucocorticoids in patients with paraquat poisoning.
  32. ncbi ED visits for drug-related poisoning in the United States, 2007
    Yuxi Xiang
    Center for Injury Research and Policy, The Research Institute at Nationwide Children s Hospital, Columbus, OH 43205, USA
    Am J Emerg Med 30:293-301. 2012
    Fatal drug-related poisoning has been well described. However, death data only show the tip of the iceberg of drug-related poisoning as a public health problem...
  33. ncbi Geographical variation in admissions due to poisoning in Sri Lanka: a time series analysis
    R Hanwella
    Department of Psychological Medicine, Faculty of Medicine, University of Colombo, Sri Lanka
    Ceylon Med J 57:152-8. 2012
    To carry out time series analyses of hospital admissions for poisoning between 1995-2008 in all districts in Sri Lanka to identify trends and geographical variations in the substances used in poisoning.
  34. pmc Outpatient treatment of acute poisonings in Oslo: poisoning pattern, factors associated with hospitalization, and mortality
    Cathrine Lund
    Department of Acute Medicine, Oslo University Hospital Ullevaal, Norway
    Scand J Trauma Resusc Emerg Med 20:1. 2012
    Most patients with acute poisoning are treated as outpatients worldwide...
  35. pmc Passive and active vaccination strategies to prevent ricin poisoning
    Seth H Pincus
    Children s Hospital and LSU Health Sciences Center, New Orleans, LA 70118, USA
    Toxins (Basel) 3:1163-84. 2011
    ..Virtually all reports of RT poisoning have been due to ingestion of castor beans, since they grow abundantly throughout the world and are readily ..
  36. ncbi Gallium poisoning: a rare case report
    Chris S Ivanoff
    College of Dentistry, The University of Tennessee Health Science Center, 875 Union Avenue, Memphis, TN 38163, USA
    Food Chem Toxicol 50:212-5. 2012
    The authors present a case of a college student who suffered acute gallium poisoning as a result of accidental exposure to gallium halide complexes. This is extremely rare and has never been reported in the literature...
  37. ncbi Postcards in Persia: randomised controlled trial to reduce suicidal behaviours 12 months after hospital-treated self-poisoning
    Hossein Hassanian-Moghaddam
    Department of Internal Medicine, Division of Clinical Toxicology, Faculty of Medicine, Shahid Beheshti University MC, Tehran, Iran
    Br J Psychiatry 198:309-16. 2011
    Hospital-treated self-poisoning is common, with limited effective interventions for reducing subsequent suicidal behaviour.
  38. pmc Management of acute paracetamol poisoning in a tertiary care hospital
    S M D K G Senarathna
    Department of Pharmacology, Faculty of Medicine, University of Colombo, Sri Lanka
    Ceylon Med J 53:89-92. 2008
    To compare the management of acute paracetamol poisoning with the best evidence available, and to determine the effect of plasma paracetamol level estimation on the management.
  39. ncbi 'Hidden' suicides amongst deaths certified as undetermined intent, accident by pesticide poisoning and accident by suffocation in Taiwan
    Shu Sen Chang
    Department of Social Medicine, University of Bristol, Bristol, UK
    Soc Psychiatry Psychiatr Epidemiol 45:143-52. 2010
    ..To identify cause-of-death categories in which suicides might be misclassified in Taiwan...
  40. ncbi [Epidemiologic survey of acute poisoning in the south area of the Community of Madrid: the VEIA 2004 study]
    P J Caballero Vallés
    Centro de Salud Angela Uriarte, Hospital Universitario 12 de Octubre, Madrid
    An Med Interna 25:262-8. 2008
    ..We present the 2004 study and compare the results with the previous years...
  41. ncbi Stable age pattern supports role of development in unintentional childhood poisoning
    M Schmertmann
    NSW Injury Risk Management Research Centre, University of New South Wales, Sydney, Australia
    Inj Prev 14:30-3. 2008
    To investigate if child development has a role in unintentional poisoning, by describing the pattern of hospitalization due to unintentional poisoning in children aged 0-4 years in New South Wales by single year of age and then assessing ..
  42. ncbi Clinical observations of cattle and buffalos with experimentally induced chronic copper poisoning
    Antonio H H Minervino
    Department of Clinical Science, College of Veterinary Medicine, University of Sao Paulo, USP, Sao Paulo, SP, Brazil
    Res Vet Sci 87:473-8. 2009
    The susceptibility of cattle and buffalos to chronic copper poisoning (CCP) was compared by using cattle (n=10) and buffalo (n=10) steers distributed into two copper supplemented (n=6) and two control (n=4) groups...
  43. ncbi Impact of restricting paracetamol pack sizes on paracetamol poisoning in the United Kingdom: a review of the literature
    Leonard C Hawkins
    Guy s and St Thomas Poisons Unit, Guy s and St Thomas NHS Foundation Trust, London, UK
    Drug Saf 30:465-79. 2007
    Paracetamol (acetaminophen) is the most common drug taken in overdose in the UK, accounting for 48% of poisoning admissions to hospital and being involved in an estimated 100-200 deaths per year...
  44. ncbi Intravenous lipid emulsions combine extracorporeal blood purification: a novel therapeutic strategy for severe organophosphate poisoning
    Yaguang Zhou
    Department of Intensive Care Unit, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Med Hypotheses 74:309-11. 2010
    Organophosphorus (OP) pesticide self-poisoning is a major clinical problem in rural Asia and it results in the death of 200,000 people every year. At present, it is lack of effective methods to treat severe organophosphate poisoning...
  45. ncbi Costs of poisoning in the United States and savings from poison control centers: a benefit-cost analysis
    T R Miller
    National Public Services Research Institute, Landover, Maryland, USA
    Ann Emerg Med 29:239-45. 1997
    Data on incidence, medical spending, and payment sources for poisoning were taken from the 1987 National Medical Expenditure Survey, 1991 US Vital Statistics, the 1992 National Hospital Discharge Survey, and 1992 poison control center ..
  46. ncbi Fatality in paraquat poisoning
    A M Sabzghabaee
    Isfahan Clinical Toxicology Research Centre, Noor and Ali Asghar General Teaching Hospital, Isfahan, Iran
    Singapore Med J 51:496-500. 2010
    Acute paraquat (PQ) poisoning continues to be a major public health concern in many developing countries...
  47. pmc Inequalities in hospital admission rates for unintentional poisoning in young children
    L Groom
    School of Community Health Sciences, University of Nottingham, Nottingham, UK
    Inj Prev 12:166-70. 2006
    To determine the relationship between deprivation and hospital admission rates for unintentional poisoning, by poisoning agent in children aged 0-4 years.
  48. ncbi Ethylene glycol poisoning
    Mila Lovric
    Clinical Institute of Laboratory Diagnosis, Zagreb University Hospital Center, Kispaticeva 12, Zagreb, Croatia
    Forensic Sci Int 170:213-5. 2007
    ..Treatment of poisoned patient for 3 weeks resulted in complete recovery...
  49. ncbi Diagnostic aspects of organophosphate poisoning
    Franz Worek
    Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, 80937 Munich, Germany
    Toxicology 214:182-9. 2005
    ..Definitive prove of exposure requires a spectrum of different methods, expensive and sophisticated equipment and will be limited to specialized laboratories...
  50. ncbi Fatal poisoning in drug addicts in the Nordic countries in 2007
    K Wiese Simonsen
    Section of Forensic Chemistry, Department of Forensic Medicine, Faculty of Health Sciences, University of Copenhagen, Frederik V s vej 11, 3 DK 2100 Copenhagen, Denmark
    Forensic Sci Int 207:170-6. 2011
    ..Norway had the highest incidence of drug addict deaths by poisoning followed by Denmark, with 8.24 and 6.92 per 100,000 inhabitants, respectively. The death rates in Finland (4...
  51. ncbi The epidemiology of glyphosate-surfactant herbicide poisoning in Taiwan, 1986-2007: a poison center study
    Ying Ju Chen
    Department of Emergency Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    Clin Toxicol (Phila) 47:670-7. 2009
    ..However, there are many controversies with regard to the exact causes and determinants of developing severe/death outcome after exposure to GlySH...
  52. ncbi Ackee fruit poisoning: an outbreak investigation in Haiti 2000-2001, and review of the literature
    Renée Joskow
    Centers for Disease Control and Prevention, National Center for Environmental Health, Environmental Hazards Health Effects Health Studies Branch, Chamblee, GA 30341, USA
    Clin Toxicol (Phila) 44:267-73. 2006
    ..This report describes the CDC field investigation in Haiti and gives a brief overview of the current state of knowledge about ackee poisoning.
  53. pmc Genetically modified ruminal bacteria protect sheep from fluoroacetate poisoning
    K Gregg
    Rumen Biotech, Murdoch University, Murdoch, Western Australia 6150, Australia
    Appl Environ Microbiol 64:3496-8. 1998
    ..Five inoculated sheep showed markedly reduced toxicological symptoms after fluoroacetate poisoning when behavioral, physiological, and histological effects were compared with those of five uninoculated control ..
  54. pmc The effects of recall on reporting injury and poisoning episodes in the National Health Interview Survey
    M Warner
    Office of Analysis and Epidemiology, National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, MD 20782, USA
    Inj Prev 11:282-7. 2005
    To examine effects of length of time between injury or poisoning and interview on the number of reported injury and poisoning episodes in the National Health Interview Survey (NHIS)...
  55. ncbi The efficacy of high doses of vitamin C in patients with paraquat poisoning
    Jeong Mi Moon
    Department of Emergency Medicine, Chonnam National University Hospital, Gwangju, South Korea
    Hum Exp Toxicol 30:844-50. 2011
    Paraquat (PQ) poisoning is an extremely difficult condition to manage clinically because of the lack of effective treatments...
  56. ncbi Hypokalemia and hypothermia are associated with 30-day mortality in patients with acute paraquat poisoning
    Meng Wei Chang
    Department of Emergency Medicine, Chang Gung Memorial Hospital, Linko Medical Center, Taoyuan, Taiwan
    Am J Med Sci 335:451-6. 2008
    Clinical predictors associated with acute paraquat (PQ) poisoning have not been systematically studied.
  57. ncbi Genetic polymorphisms in hMTH1, hOGG1 and hMYH and risk of chronic benzene poisoning in a Chinese occupational population
    Fen Wu
    Department of Occupational Health and Toxicology, School of Public Health, Fudan University, Shanghai, China
    Toxicol Appl Pharmacol 233:447-53. 2008
    ..damage to DNA induced by benzene is an important mechanism of its genotoxicity, which leads to chronic benzene poisoning (CBP)...
  58. ncbi Management of the cardiovascular complications of tricyclic antidepressant poisoning : role of sodium bicarbonate
    Sally M Bradberry
    National Poisons Information Service Birmingham Centre, City Hospital, Birmingham, UK
    Toxicol Rev 24:195-204. 2005
    ..colloid was also given) and improved mental status in patients with moderate to severe tricyclic antidepressant poisoning. This clinical study supports the use of sodium bicarbonate in the management of the cardiovascular ..
  59. ncbi Glyphosate poisoning
    Sally M Bradberry
    National Poisons Information Service Birmingham Centre and West Midlands Poisons Unit, City Hospital, Birmingham, UK
    Toxicol Rev 23:159-67. 2004
    ..As a result, human poisoning with this herbicide is not with the active ingredient alone but with complex and variable mixtures...
  60. ncbi First report in a river in France of the benthic cyanobacterium Phormidium favosum producing anatoxin-a associated with dog neurotoxicosis
    Muriel Gugger
    USM0505 Ecosystèmes et interactions toxiques, M N H N, Paris, France
    Toxicon 45:919-28. 2005
    ..Finally, several cyanobacterial strains were isolated from the green biofilm and tested for anatoxin-a production. Phormidium favosum was identified as a new anatoxin-a producing species...
  61. pmc Prognostic value of long QT interval in acute and severe organophosphate poisoning
    Shahin Shadnia
    Loghman Hakim Hospital Poison Center, Faculty of Medicine and Toxicological Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
    J Med Toxicol 5:196-9. 2009
    Suicidal poisoning with organophosphorus (OP) pesticides is common, particularly from rural areas. This highlights the importance of determining an OP poisoning prognosis to decide how aggressive treatment should be...
  62. pmc The prevalence of previous self-harm amongst self-poisoning patients in Sri Lanka
    Fahim Mohamed
    South Asian Clinical Toxicology Research Collaboration, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka
    Soc Psychiatry Psychiatr Epidemiol 46:517-20. 2011
    ..The objective of this study was to investigate the prevalence of previous self-harm among a consecutive series of self-harm patients presenting to hospitals in rural Sri Lanka...
  63. ncbi Emergency department management and outcome for self-poisoning: a cohort study
    Navneet Kapur
    Centre for Suicide Prevention, Department of Psychiatry and Behavioural Sciences, 7th Floor Williamson Building, University of Manchester, Oxford Road, M13 9PL, Manchester, UK
    Gen Hosp Psychiatry 26:36-41. 2004
    Self-poisoning in adults is an important public health problem across the world, but evidence to guide psychological management is lacking...
  64. pmc Risk factors in the development of adverse reactions to N-acetylcysteine in patients with paracetamol poisoning
    L E Schmidt
    Department of Hepatology A and Department of Clinical Pharmacology Q, Rigshospitalet, Copenhagen, Denmark
    Br J Clin Pharmacol 51:87-91. 2001
    To identify risk factors in the development of side-effects to N-acetylcysteine (NAC) in patients with paracetamol poisoning.
  65. ncbi Clinical profile and outcome of children presenting with poisoning or intoxication: a hospital based study
    S Budhathoki
    Department of Paediatrics and Adolescent Medicine, BP Koirala Institute of Health Sciences, Dharan, Nepal
    Nepal Med Coll J 11:170-5. 2009
    b>Poisoning is a common preventable cause of morbidity and mortality in children. Most of the poisoning in children less than 5 years of age is accidental...
  66. ncbi Acute pesticide poisoning: 15 years experience of a large North-West Indian hospital
    R Murali
    Postgraduate Institute of Medical Education and Research, Department of Internal Medicine, Nehru Hospital, Chandigarh, India
    Clin Toxicol (Phila) 47:35-8. 2009
    Acute pesticide poisoning is an important cause of morbidity and mortality in developing countries. Better preventive and management strategies can be developed if the incidence and pattern of acute poisoning are known.
  67. ncbi Deliberate poisoning with dinitrophenol (DNP): an unlicensed weight loss pill
    James Bartlett
    St Mary s Hospital, Praed Street, London W2 1NY, UK
    Emerg Med J 27:159-60. 2010
    ..A summary of currently recommended treatment and a review of the literature on DNP is included, as well as a discussion of therapies that may be effective in treating hyperthermia in this situation...
  68. ncbi [Severity factors of aluminium phosphide poisoning (Phostoxin)]
    M Hajouji Idrissi
    Service de réanimation et de toxicologie clinique, Hopital Avicenne, Rabat, Maroc
    Ann Fr Anesth Reanim 25:382-5. 2006
    To determine characteristics of acute aluminum phosphide poisoning (AAlPP) and to evaluate its severity factors.
  69. ncbi Self-poisoning during pregnancy as a model for teratogenic risk estimation of drugs
    A E Czeizel
    Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary
    Toxicol Ind Health 24:11-28. 2008
    ..3%) were evaluated. The self-poisoning model appears to have several benefits (e.g., dose-response estimation) in comparison with other methods...
  70. ncbi Evaluation of subchronic chlorpyrifos poisoning on hematological and serum biochemical changes in mice and protective effect of vitamin C
    Suleiman Ambali
    Department of Veterinary Physiology and Pharmacology Ahmadu Bello University, Zaria, Kaduna State, Nigeria
    J Toxicol Sci 32:111-20. 2007
    ....
  71. ncbi Methemoglobinemia with aluminum phosphide poisoning
    B Lakshmi
    Am J Emerg Med 20:130-2. 2002
  72. ncbi A retrospective 7-years study of aluminum phosphide poisoning in Tehran: opportunities for prevention
    S Shadnia
    Loghman Hakim Hospital Poison Center, School of Medicine and Toxicological Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
    Hum Exp Toxicol 28:209-13. 2009
    The objective of this study was to survey aluminum phosphide (AIP) poisoning in a referral poisoning hospital in Tehran servicing an estimation of 10,000,000 populations...
  73. ncbi Human paraoxonase: a promising approach for pre-treatment and therapy of organophosphorus poisoning
    Daniel Rochu
    Departement de Toxicologie, Centre de Recherches du Service de Sante des Armees, BP 87, 38702 La Tronche Cedex, France
    Toxicology 233:47-59. 2007
    The limited efficiency of medical countermeasures against poisoning by nerve agent justifies efforts to find new prophylactic means and new antidotes...
  74. ncbi Severe paraquat poisoning: clinical and radiological findings in a survivor
    Fábio Fernandes Neves
    Faculdade de Medicina de Ribeirao Preto, Hospital das Clinicas, Universidade de Sao Paulo, Ribeirao Preto, SP, Brasil
    J Bras Pneumol 36:513-6. 2010
    ..We also present a brief review of the literature, as well as a discussion of the therapeutic algorithm for severe paraquat poisoning.
  75. ncbi Poisoning severity score, Glasgow coma scale, corrected QT interval in acute organophosphate poisoning
    Okhan Akdur
    Canakkale Onsekiz Mart University Faculty of Medicine, Department of Emergency Medicine, Canakkale, Turkey
    Hum Exp Toxicol 29:419-25. 2010
    The aim of this study was to investigate effectiveness of the poisoning severity score (PSS), Glasgow coma scale (GCS), and corrected QT (QTc) interval in predicting outcomes in acute organophosphates (OP) poisoning...
  76. ncbi Prognostic factors of acute aluminum phosphide poisoning
    M Louriz
    Medical ICU, Ibn Sina Hospital, Rabat, Morocco
    Indian J Med Sci 63:227-34. 2009
    In Morocco, acute aluminum phosphide poisoning (AAlPP) is a serious health care problem. It results in high mortality rate despite the progress of critical care.
  77. ncbi Unintentional child poisonings treated in United States hospital emergency departments: national estimates of incident cases, population-based poisoning rates, and product involvement
    Robert L Franklin
    Directorate for Economic Analysis, US Consumer Product Safety Commission, 4330 East West Highway, Bethesda, MD 20814, USA
    Pediatrics 122:1244-51. 2008
    The goals were to develop national estimates of unintentional child poisoning cases treated in US hospital emergency departments, to determine population-based poisoning rates, and to evaluate characteristics of the victims and the ..
  78. pmc Presentations of patients of poisoning and predictors of poisoning-related fatality: findings from a hospital-based prospective study
    Hsin Ling Lee
    Graduate Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan City 704, Taiwan
    BMC Public Health 8:7. 2008
    b>Poisoning is a significant public health problem worldwide and is one of the most common reasons for visiting emergency departments (EDs), but factors that help to predict overall poisoning-related fatality have rarely been elucidated...
  79. ncbi The pharmacology, toxicology, and medical treatment of sulphur mustard poisoning
    Mahdi Balali-Mood
    Medical Toxicology Centre, Imam Reza Hospital, Medical School, Mashhad University of Medical Sciences, Mashhad 91735 348, Islamic Republic of Iran
    Fundam Clin Pharmacol 19:297-315. 2005
    ..The pattern of immediate and long-term toxic effects following exposure to SM is reviewed in this article with special references to the recent data available from over 100,000 chemical casualties incurred during the Iran-Iraq conflict...
  80. pmc Personal and professional challenges in the management of deliberate self-poisoning patients in rural Sri Lanka: a qualitative study of rural hospital doctors' experiences and perceptions
    Lalith Senarathna
    Faculty of Medicine, South Asian Clinical Toxicology Research Collaboration, University of Peradeniya, Peradeniya, Sri Lanka
    BMC Public Health 8:373. 2008
    Deliberate self-poisoning is a major public heath issue in developing countries. In rural Sri Lanka deliberate self-poisoning is one of the leading causes of hospital death...
  81. pmc Cost to government health-care services of treating acute self-poisonings in a rural district in Sri Lanka
    Kanchana Wickramasinghe
    Institute of Policy Studies of Sri Lanka, Colombo, Sri Lanka
    Bull World Health Organ 87:180-5. 2009
    To estimate the direct financial costs to the Sri Lanka Ministry of Health of treating patients after self-poisoning, particularly from pesticides, in a single district.
  82. ncbi Deaths from pesticide poisoning in South Korea: trends over 10 years
    Won Jin Lee
    Department of Preventive Medicine, College of Medicine, Graduate School of Public Health, Korea University, Seoul, South Korea
    Int Arch Occup Environ Health 82:365-71. 2009
    Pesticide poisoning is a major cause of death in the world. The objective of this study was to examine the trends of pesticide poisoning deaths and their epidemiologic characteristics in South Korea.
  83. ncbi Expert opinion: fomepizole may ameliorate the need for hemodialysis in methanol poisoning
    K E Hovda
    Department of Acute Medicine, Ullevaal University Hospital, Oslo, Norway
    Hum Exp Toxicol 27:539-46. 2008
    Fomepizole is now the antidote of choice in methanol poisoning. The use of fomepizole may also change the indications for hemodialysis in these patients. We have addressed this change in a review of articles on methanol poisonings...
  84. ncbi A clinical and laboratory profile of Cleistanthus collinus poisoning
    D K S Subrahmanyam
    Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research
    J Assoc Physicians India 51:1052-4. 2003
    1. To study the clinical features in patients with Cleistanthus collinus poisoning, 2...
  85. pmc Pre-hospital treatment of acute poisonings in Oslo
    Fridtjof Heyerdahl
    Department of Acute Medicine, Ullevaal University Hospital, Oslo, Norway
    BMC Emerg Med 8:15. 2008
    ..Poisoned patients are often treated in and discharged from pre-hospital health care settings. Studies of poisonings should therefore not only include hospitalized patients...
  86. ncbi Pattern of acute poisoning in Tehran-Iran in 2003
    Shahin Shadnia
    Loghman Hakim Hospital Poison Center, Faculty of Medicine and Toxicological Research Center, Shaheed Beheshti University of Medical Sciences, Tehran
    Hum Exp Toxicol 26:753-6. 2007
    To characterize the poisoning cases admitted to the Loghman-Hakim Hospital Poison Center (a teaching reference hospital of poisoning) in Tehran, Iran...
  87. ncbi Clinical assessment compared to laboratory screening in acutely poisoned patients
    F Heyerdahl
    Department of Acute Medicine, Ullevaal University Hospital, Oslo, Norway
    Hum Exp Toxicol 27:73-9. 2008
    ..The reliability of the clinical diagnoses varied to such an extent that agents, which are important to recognize for specific treatment, should be tested for...
  88. ncbi The early prognostic factors of glyphosate-surfactant intoxication
    Ching Hsing Lee
    Department of Emergency Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan Hsien, Taiwan 333
    Am J Emerg Med 26:275-81. 2008
    ..The purpose of this study was to establish an early prognostic model of patients with glyphosate-surfactant (GlySH) herbicide intoxication...
  89. ncbi Poisoning severity score. Grading of acute poisoning
    H E Persson
    Swedish Poisons Information Centre, Karolinska Hospital, Stockholm, Sweden
    J Toxicol Clin Toxicol 36:205-13. 1998
    A standardized and generally applicable scheme for grading the severity of poisoning allows a qualitative evaluation of morbidity and facilitates comparability of data...
  90. ncbi Opioid analgesics and rates of fatal drug poisoning in the United States
    Leonard J Paulozzi
    Division of Unintentional Injury Prevention, National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Am J Prev Med 31:506-11. 2006
    To determine whether the variability in rate of sale of prescription opioid analgesics is related to the variability in rates of drug poisoning mortality among states in the United States in 2002.
  91. pmc Randomised controlled trial of brief psychological intervention after deliberate self poisoning
    E Guthrie
    School of Psychiatry and Behavioural Sciences, University of Manchester, Rawnsley Building, Manchester Royal Infirmary, Manchester M13 9WL
    BMJ 323:135-8. 2001
    ..brief psychological intervention (brief psychodynamic interpersonal therapy) for patients after deliberate self poisoning compared with usual treatment...
  92. ncbi Identification of a benthic microcystin-producing filamentous cyanobacterium (Oscillatoriales) associated with a dog poisoning in New Zealand
    Susanna A Wood
    Cawthron Institute, Freshwater, Private Bag 2, Nelson 7001, New Zealand
    Toxicon 55:897-903. 2010
    ..To our knowledge, however, this is the first instance of a benthic microcystin-producing species causing an animal death in New Zealand...
  93. ncbi National Association of Medical Examiners position paper on the certification of cocaine-related deaths
    Boyd G Stephens
    Office of the Chief Medical Examiner, City and County of San Francisco, San Francisco, California 94103 4603, USA
    Am J Forensic Med Pathol 25:11-3. 2004
    ..These guidelines are intended for use by practicing medical examiners and physicians who certify drug deaths, as well as providing education tools for students...
  94. pmc Understanding parental motivators and barriers to uptake of child poison safety strategies: a qualitative study
    L Gibbs
    School of Health and Social Development, Deakin University, Victoria, Australia
    Inj Prev 11:373-7. 2005
    ..To develop an understanding of factors acting as barriers and motivators to parental uptake of child poison safety strategies...
  95. ncbi Sodium fluoroacetate poisoning
    Alex T Proudfoot
    National Poisons Information Service Birmingham Centre, City Hospital, Birmingham, UK
    Toxicol Rev 25:213-9. 2006
    ..Many of the features of fluoroacetate poisoning are, therefore, largely direct and indirect consequences of impaired oxidative metabolism...
  96. ncbi Reducing the incidence of acute pesticide poisoning by educating farmers on integrated pest management in South India
    Francesca Mancini
    Biological Farming Systems, Wageningen University
    Int J Occup Environ Health 15:143-51. 2009
    Sixty-five farmers reported on pesticide use and the signs and symptoms of acute pesticide poisoning when using two different plant protection strategies: in 2003 using chemical controls and in 2004 using an approach to Integrated Pest ..
  97. ncbi Diltiazem poisoning treated with hyperinsulinemic euglycemia therapy and intravenous lipid emulsion
    Virginie Montiel
    Department of Intensive Care, Cliniques St Luc, 10 Avenue Hippocrate, Brussels, Belgium
    Eur J Emerg Med 18:121-3. 2011
    ..The mechanism of action of ILE is not known, including its role in insulin resistance and myocardial metabolism in calcium-channel blocker poisoning.
  98. ncbi The Nicaraguan Pesticide Poisoning Register: constant underreporting
    Marianela Corriols
    OPS Nicaragua, Managua, Nicaragua
    Int J Health Serv 38:773-87. 2008
    ..The authors estimate that, nationally, about 30,000 pesticide poisoning cases receiving medical treatment were not reported...
  99. ncbi Oral or intravenous N-acetylcysteine: which is the treatment of choice for acetaminophen (paracetamol) poisoning?
    N A Buckley
    Department of Clinical Pharmacology, Royal Adelaide Hospital, Australia
    J Toxicol Clin Toxicol 37:759-67. 1999
    ..route and duration of administration for N-acetyl-cysteine in the management of acetaminophen (paracetamol) poisoning are controversial...
  100. pmc Vaccine-induced intestinal immunity to ricin toxin in the absence of secretory IgA
    Lori M Neal
    Division of Infectious Disease, Wadsworth Center, New York State Department of Health, 120 New Scotland Avenue, Albany, NY 12208, USA
    Vaccine 29:681-9. 2011
    ..g., intramuscular and intradermal) is sufficient to elicit protection against both systemic and mucosal ricin challenges...
  101. ncbi Epidemiology of organophosphate pesticide poisoning in Taiwan
    Tzeng Jih Lin
    Department of Emergency, Kaohsiung Medical University Hospital, Taipei, Taiwan
    Clin Toxicol (Phila) 46:794-801. 2008
    The nationwide epidemiology of organophosphate pesticide (OP) poisoning has never been reported in detail for Taiwan.

Research Grants68

  1. Multi-targeted Countermeasures against Acute and Delayed Effects of OP Exposure
    John A Butera; Fiscal Year: 2013
    ..Currently available countermeasures for OP poisoning involve the simultaneous administration (via autoinjectors) of three different agents: (1) an anticholinergic ..
  2. Protection of Brain Injury from Cyanide Poisoning by Carnosic Acid
    Stuart A Lipton; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cyanide poisoning is a potential bioterrorist agent, is life threatening, and acute exposure results in hypoxic brain injury, cardiopulmonary failure, and death within minutes to hours...
  3. Intranasal CNS delivery of drugs against organophosphorous threat agents
    ARYAN MANGALAM NAMBOODIRI; Fiscal Year: 2013
    ..to the accumulation of acetylcholine at synaptic and neuromuscular junctions leading to symptoms of acute CTA poisoning including salivation, lacrimation, defecation, muscular twitching, seizures/status epilepticus and ultimately ..
  4. Vaccine Assembly from Surface Proteins of Staphylococcus Aureus
    Olaf Schneewind; Fiscal Year: 2013
    ..diseases includes also endocarditis, septic arthritis, toxic shock syndrome, scalded skin syndrome and food poisoning. S. aureus strains exhibiting multiple antibiotic resistances, methicillin-resistant S...
  5. High affinity capturing agents for strychnine
    Kit S Lam; Fiscal Year: 2011
    ..Unfortunately there is no antidote for strychnine. Treatments for strychnine poisoning are primarily supportive and symptomatic care...
  6. A new ultra-low field in-vivo EPR technology for biomedical applications
    Inseob Hahn; Fiscal Year: 2011
    ..HEALTH RELEVANCE (provided by applicant): Free radicals play a major role in human diseases such as iron sulfate poisoning, ionizing radiation, oxygen toxicity in premature infants treated with hyperbaric oxygen, ultraviolet radiation-..
  7. A new ultra-low field in-vivo EPR technology for biomedical applications
    Inseob Hahn; Fiscal Year: 2012
    ..HEALTH RELEVANCE (provided by applicant): Free radicals play a major role in human diseases such as iron sulfate poisoning, ionizing radiation, oxygen toxicity in premature infants treated with hyperbaric oxygen, ultraviolet radiation-..
  8. Early Disease Biomarkers of PCB-exposed Human Population
    Sisir K Dutta; Fiscal Year: 2010
    ..Republic is associated with diseases caused by oxidative stresses, endocrine disruption, and mitochondrial poisoning. This hypothesis is based on the following observations...
  9. Regulation of Odorant Receptor Gene Expression
    Paul Feinstein; Fiscal Year: 2013
    ..Loss of olfactory function leads to poor feeding in geriatric populations as well as higher incidence of food poisoning. Studying odorant receptor gene expression will give insights into how the olfactory system is put together and ..
  10. Metal Exposure and Children?s Preschool Neurodevelopment
    David C Bellinger; Fiscal Year: 2012
    ..While lead (Pb) poisoning has been extensively studied, the neurotoxicities and dose-effect relationships associated with other heavy ..
  11. INTRACELLULAR CALCIUM IN HAIR CELLS
    Robert Fettiplace; Fiscal Year: 2013
    ..channels is probably common to all hair cells and may be the site of irreversible damage during noise exposure, poisoning with ototoxic agents or aging...
  12. Mechanism and Treatment of nerve agent-induced seizures
    Jaideep Kapur; Fiscal Year: 2010
    ..Seizures were also observed in humans exposed to nerve agent poisoning during the Iran-Iraq war, and in the Tokyo subway attacks where sarin and VX were used...
  13. Hepatic CYP enzymes and host-pathogen interactions
    Edward T Morgan; Fiscal Year: 2013
    ..In mice infected with C. rodentium, a model of E. Coli food poisoning in humans, a number of P450 enzymes in the liver are moderately down-regulated...
  14. Does the extreme variability of methadone metabolism have an epigenetic cause?
    Gavin R Schnitzler; Fiscal Year: 2010
    ..Indeed, a recent CDC report indicated that heroin and other opiates account for ~30% of all inadvertent poisoning deaths in the United States...
  15. Bangladesh Centre for Global Environmental and Occupational Health
    Dewan Shamsul Alam; Fiscal Year: 2013
    ..The WHO has designated arsenic in drinking water in Bangladesh as the largest mass poisoning event in human history...
  16. High-throughput multiplex microsphere screening for toxin protease inhibitors
    Steven W Graves; Fiscal Year: 2012
    ..In this way, this proposal will discover important new compounds that can be the basis of new pharmaceuticals to treat Botulinum neurotoxin poisoning or late stage Anthrax infections.
  17. Enforcing Underage Drinking Laws (EUDL)
    Christopher Spera; Fiscal Year: 2009
    ..car crashes;unintentional injuries from burns, falls, and drownings;and death from alcohol poisoning. Research has shown that starting to drink at an early age is associated with alcohol dependence and related ..
  18. Oxygen/Nitrogen Stress in Acetaminophen Hepatotoxicity
    Jack A Hinson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Acetaminophen (APAP) poisoning is the most common cause of acute liver failure in the U.S...
  19. Intralipid: A novel frontline countermeasure for brodifacoum poisoning
    Douglas L Feinstein; Fiscal Year: 2013
    ..Reported clinical occurrences of superwarfarin poisoning have reached over 16,000 per year in the USA, with >90% in children under age 6...
  20. Re-Wiring Cellular Metabolism to Control Biofilm Formation and Virulence BY...
    Thomas K Wood; Fiscal Year: 2011
    ..g., biocorrosion, biocatalysis, rhizoremediation, food poisoning) whereas previously biofilms have been studied primarily as a means toward eradicating them...
  21. Developmental neurotoxicity of sarin and soman in guinea pigs
    Edson X Albuquerque; Fiscal Year: 2012
    ..a drug currently approved to treat Alzheimer's disease, emerged as an effective antidote against acute OP poisoning in neonatal, prepubertal, and adult guinea pigs...
  22. INFLAMMATORY RESPONSES IN THE TOXICITY OF RICIN
    Bruce Magun; Fiscal Year: 2009
    ..The development of interventional remedies in cases of poisoning by ricin and other ribosome-directed toxins will depend critically on our improved understanding of the primary ..
  23. Role of the ribosomal stalk in the activity of Shiga toxins
    Nilgun E Tumer; Fiscal Year: 2013
    ..There are no antidotes or therapeutics effective against Shiga toxin-mediated hemolytic uremic syndrome (HUS). We propose to understand how Shiga toxins interact with ribosomes to develop remedies against E. coli poisoning.
  24. New Pathways in Thrombosis and Inflammation Mediated by Semaphorin-Plexin Signali
    Guy A Zimmerman; Fiscal Year: 2010
    ..often occluding blood vessels) and inflammation contribute directly to heart attack, stroke, sepsis ("blood poisoning"), acute lung injury, and a host of other devastating human disorders...
  25. Toxic Metal Complexation by de Novo Designed Peptides
    Vincent L Pecoraro; Fiscal Year: 2013
    Abstract Heavy metal poisoning by elements such as mercury, lead, cadmium, and arsenic is a significant human health problem...
  26. Stomate-based innate immunity against bacterial infection in Arabidopsis
    Maeli Melotto; Fiscal Year: 2012
    ..of fresh vegetables is a major public health concern and a potential bio-terrorist threat as a source of food poisoning. PUBLIC HEALTH RELEVANCE: This proposal describes basic research on the molecular basis of innate immunity of ..
  27. Dipstick Assay for Detection of Acetaminophen Protein Adducts
    Laura P James; Fiscal Year: 2010
    ..Development of a sensitive and rapid assay for APAP-protein adducts will enhance the diagnosis of APAP poisoning in clinical settings and lead to the earlier identification of individuals at risk for severe liver toxicity, ..
  28. Next Generation Oxime Therapeutic for Chemical Agent Inhibited CNS (Brain) ChEs
    Richard K Gordon; Fiscal Year: 2010
    Current treatment of acute pesticide or organophosphate (OP) poisoning includes a combined administration of a cholinesterase reactivator (oxime), a muscarinic receptor antagonist (atropine) and an anticonvulsant (diazepam)...
  29. Thromboresistant Polymers via Catalytic Generation of NO
    Mark E Meyerhoff; Fiscal Year: 2012
    ..species, and assessing changes in catalytic NO generation as a function of time (due to catalytic site leaching, poisoning, etc...
  30. Strategies for Heavy Metal Detoxification
    Gerard Parkin; Fiscal Year: 2013
    ..While the outbreak of methyl mercury poisoning in Japan was a result of toxic release from a nearby chemical plant, methyl mercury compounds are also ..
  31. Chemical Glycobiology on Anthracyclines
    Peng Wang; Fiscal Year: 2009
    ..The molecular mechanisms of Top2 &Top1 poisoning will be clarified experimentally...
  32. Crystalline hydroxocobalamin and methemoglobin as a treatment of H2S intoxication
    PHILIPPE A HAOUZI; Fiscal Year: 2013
    ..Both agents are safe (high dose of Vitamin B12 is already FDA approved for cyanide poisoning), can be stored as a kit, in a powder form, and can easily be administered to humans following H2S exposure...
  33. Mechanisms of Sulfur Mustard Toxicology
    YIHUA JAN; Fiscal Year: 2010
    ..Successful therapy for sulfur mustard poisoning will depend on the development of drugs that target one or more of its sites of action...
  34. Aerosol Delivery of a Recombinant Butyrylcholinesterase "BioShield" to Protect Ag
    YVONNE J ROSENBERG; Fiscal Year: 2012
    ..Usually, treatment of insecticide poisoning consists of supportive care and specific therapy e.g...
  35. Ethanol Dependence and Kappa Receptor Antagonists
    MARC REZA AZAR; Fiscal Year: 2011
    ..crashes), alcoholism is associated with chronic liver disease, cancers, cardiovascular disease, acute alcohol poisoning (i.e., alcohol toxicity), and fetal alcohol syndrome...
  36. Role of Astrocyte Injury in Neuroprotection
    Martin A Philbert; Fiscal Year: 2012
    ..and Parkinson's disease and in energy deprivation syndromes such as thiamine deficiency and antimetabolite poisoning. The prevailing model of healthy astrocyte-neuron interaction is one of continuous and intimate physical contact ..
  37. Age and sex effects on nerve agent damage to the brain and antidotal therapies
    Edson X Albuquerque; Fiscal Year: 2010
    ..The limitations of available therapies against OP poisoning are well recognized, and more effective antidotes have to be developed...
  38. Development of High Affinity Analogues of Brevenal: Novel Molecular Probes for Ne
    Mary C Wolf; Fiscal Year: 2011
    ..Implications for treatment of neurotoxic shellfish poisoning (NSP due to brevetoxin) and ciguatera fish poisoning (CFP due to ciguatoxin), or more broadly for the treatment ..
  39. Targeting Cellular Processes to Counter the Effects of BoNT Intoxication
    Sina Bavari; Fiscal Year: 2013
    ..pharmacologically active small molecules with unique mechanisms of action for countering BoNT/A, /B and /E poisoning. Following identification, lead compounds will be characterized and optimized via rounds of chemical synthesis ..
  40. Catalytic Approach to Treatment of Cyanide Poisoning
    SIGRIDUR G SUMAN; Fiscal Year: 2010
    ..Cyanide poisoning is rapid and treatment options are limited...
  41. Second Generation Small Molecule Inhibitors of Botulinum Neurotoxins
    Sina Bavari; Fiscal Year: 2013
    ..therapeutic to counter the inevitable suffocation and certain death resulting from the paralysis induced by BoNT poisoning. We propose the use of therapeutically viable chemicals as drugs...
  42. Domoic Acid Neurotoxicity in Native Americans
    Lynn M Grattan; Fiscal Year: 2013
    ..Survivors were left with a profound memory disorder, Amnesic Shellfish poisoning (ASP). Based upon animal models, regulatory levels of DA in shellfish were established...
  43. A Novel Therapy for Staphylococcal Enterotoxin B Poisoning
    Kenneth J Piller; Fiscal Year: 2010
    ..The completion of these Phase II studies will provide necessary information to fulfill some of the requirements set by the FDA for developing vaccines against agents of bioterrorism. ..
  44. Ras18-mediated Fanconi Anemia pathway activation in response to camptothecin
    Komaraiah Palle; Fiscal Year: 2013
    ..under Specific Aim 3 will determine the roles of Rad18 in different phases of the cell cycle in response to CPT poisoning of Top1...
  45. Nitrites as Antidotes for Hydrogen Sulfide Poisoning
    James Peterson; Fiscal Year: 2013
    ..there appears to be no FDA-approved antidote and/or reliable protocol for treating acute hydrogen sulfide (H2S) poisoning. Emergency medicine bulletins/pamphlets issued by several state authorities suggest the use of cyanide antidote ..
  46. Pseudomonas aeruginosa genomic islands and virulence factors
    VANDERLENE LIU KUNG; Fiscal Year: 2011
    ..such as lead and asbestos to microbial toxins such as afiatoxin and staphylococcalenterotoxins involved in food poisoning. Environmental bacteria in particular represent a large reservoir of agents capable of producing diverse toxins ..
  47. Unintentional Poisoning from Prescription Drug Overdoses Among Veterans
    Matthew J Miller; Fiscal Year: 2010
    ..Because this project involves a partnership with the Veterans Healthcare Administration (VHA), findings could lead to particularly prompt adoption of safer opioid prescribing practices for veterans receiving care within the VHA system. ..
  48. Structural and functional studies of botulinum neurotoxin
    Rongsheng Jin; Fiscal Year: 2013
    ..Clinical formulations are also composed of BoNT PTCs. Accidental BoNT poisoning mainly occurs through oral ingestion of tainted food products...
  49. Therapeutic Human Monoclonal Antibodies Against Staphylococcal Enterotoxin B (SEB
    M Javad Aman; Fiscal Year: 2012
    ..SEB is also a major cause of food poisoning and toxic shock syndrome. Currently, there are no therapeutics available against SEB for human use...
  50. Mechanism of Cell Membrane Targeting by Vibrio Cholerae Cytolysin
    RICHARD A OLSON; Fiscal Year: 2012
    ..with important human health implications, including toxins produced by Vibrio vulnificus, a cause of deadly food poisoning and sepsis...
  51. Effectiveness of Mandatory Prescription Drug Monitoring
    Guohua Li; Fiscal Year: 2012
    ..prescription drug overdoses;and (3) to examine the association between state PDMPs and the likelihood that a poisoning death is due to unintentional prescription drug overdose...
  52. Cytoskeleton polymerization dynamics in the cell cycle
    Timothy J Mitchison; Fiscal Year: 2010
    ..We will use biochemistry and microscopy o understand the addition and loss reactions. The food-poisoning bacterium, enters human cells and generates a "comet tail" of actin fibers that propels the bacterium...
  53. Effect of chronic antipsychotic medication administration on cocaine poisoning
    KENNON JAMES HEARD; Fiscal Year: 2010
    ..research training and experience that he requires to become a successful independent investigator focusing on poisoning from drugs of abuse. As an emergency physician and medical toxicologist, Dr...
  54. Parameters Involved in Metal Recognition
    Michael J Maroney; Fiscal Year: 2013
    ..may lead to the development of therapies for the treatment of patients with metal overloads (including poisoning) or deficiencies resulting from defects in metal metabolism, to the design of new antibiotics that interfere ..
  55. VESTIBULAR REGULATION OF RESPIRATORY MUSCLE ACTIVITY
    Bill J Yates; Fiscal Year: 2013
    ..Nausea and vomiting can occur during poisoning, cancer chemotherapy, recovery from anesthesia, activities in virtual environments (including civilian and ..
  56. Health and Biomedical Science for a Diverse Community, Phase II
    Bertram Lubin; Fiscal Year: 2009
    ..Traumatic Brain Injuries;Unit 3. Infectious Diseases and Immunity;Unit 4. Environmental Toxics: Poisoning Prevention. Fifth Grade: Unit 1. Nutrition: Diabetes;Unit 2. Asthma and Lung Disease;Unit 3...
  57. Novel therapeutic approaches to treatment of botulinum neurotoxin poisoning
    Eric A Johnson; Fiscal Year: 2013
    ..Our current methods can produce sufficient quantities for in vitro and in vivo testing. These ABTs can be administered in a post-exposure setting by oral or inhalational routes. ..
  58. Unintentional Prescription Opioid Poisoning Deaths in Connecticut and Rhode Islan
    Traci C Green; Fiscal Year: 2011
    ....
  59. Regional Brain Manganese Accumulation and Functional Consequences in Welders
    Xuemei Huang; Fiscal Year: 2013
    ..Historically, the pallidal index has served as an MRI measure for overt Mn poisoning. Its utility has been questioned because regions other than the globus pallidus (GP) have been neglected for ..
  60. Quinoline-based Inhibitors of BoNT/A LC
    John D Williams; Fiscal Year: 2012
    ..to develop small molecule inhibitors of the BoNT/A light chain (LC) metalloprotease activity to treat botulinum poisoning. Our strategy is to optimize a novel chemotype of BoNT/A LC inhibitors to improve potency, selectivity, and drug-..
  61. Effects of Lead on Neuronal Differentiation in Human Embryonic Stem Cells
    Douglas M Ruden; Fiscal Year: 2013
    ..Lead poisoning remains a significant health problem in the United States...
  62. Central Respiratory Effects of Organophosphate Poisoning
    Romolo J Gaspari; Fiscal Year: 2010
    ..First, the candidate plans to test the hypothesis that death from acute organophosphate poisoning is caused by apnea due to acute loss of rhythmic output of the central respiratory oscillator in the brainstem...
  63. A Plant-Derived Recombinant Bioscavenger to Prevent Insecticide Neurotoxicity
    Yvonne Rosenberg; Fiscal Year: 2007
    ..Currently, treatment of insecticide poisoning consists of supportive care and specific therapy e.g...
  64. Male Subfertility By Ni2+ Poisoning of Ca2+ Channels ?
    Susan Benoff; Fiscal Year: 2001
    ....
  65. d-Penicillamine Chelation in lead-poisoned Children - A Phase ll/lll Trial
    Michael Shannon; Fiscal Year: 2007
    ..Lead poisoning in children is unequivocally harmful, producing the neurodevelopmental consequences of cognitive losses, ..
  66. Fullerenes Counteracting Organophosphorus Threats
    Marion F Ehrich; Fiscal Year: 2010
    ..When the neurotransmitter acetylcholine is not destroyed cholinergic poisoning can result...
  67. SCF in liver repair after hepatectomy or toxic injury
    Lisa Colletti; Fiscal Year: 2006
    ..S. Acetaminophen poisoning causes direct hepatocyte damage and patient survival relies heavily upon the liver's ability to recover ..