peritonitis

Summary

Summary: INFLAMMATION of the PERITONEUM lining the ABDOMINAL CAVITY as the result of infectious, autoimmune, or chemical processes. Primary peritonitis is due to infection of the PERITONEAL CAVITY via hematogenous or lymphatic spread and without intra-abdominal source. Secondary peritonitis arises from the ABDOMINAL CAVITY itself through RUPTURE or ABSCESS of intra-abdominal organs.

Top Publications

  1. pmc Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-κB signaling in resident macrophages
    Hosoon Choi
    Texas A and M Health Science Center, College of Medicine, Institute for Regenerative Medicine at Scott and White, Temple, TX 76502, USA
    Blood 118:330-8. 2011
  2. pmc Resolvin E1 and protectin D1 activate inflammation-resolution programmes
    Jan M Schwab
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 447:869-74. 2007
  3. ncbi Transcriptomic analyses of murine resolution-phase macrophages
    Melanie J Stables
    Centre for Clinical Pharmacology and Therapeutics, Division of Medicine, University College London, United Kingdom
    Blood 118:e192-208. 2011
  4. pmc Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 206:15-23. 2009
  5. pmc Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis
    Matthew Spite
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 461:1287-91. 2009
  6. ncbi Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation
    S M Hurst
    Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3US, Wales, United Kingdom
    Immunity 14:705-14. 2001
  7. pmc Heat shock protein 72 enhances autophagy as a protective mechanism in lipopolysaccharide-induced peritonitis in rats
    Shu Li
    Department of Nephrology, First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    Am J Pathol 179:2822-34. 2011
  8. pmc Saturated-efferocytosis generates pro-resolving CD11b low macrophages: modulation by resolvins and glucocorticoids
    Sagie Schif-Zuck
    Department of Biology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel
    Eur J Immunol 41:366-79. 2011
  9. pmc Pathophysiological changes to the peritoneal membrane during PD-related peritonitis: the role of mesothelial cells
    Susan Yung
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    Mediators Inflamm 2012:484167. 2012
  10. ncbi Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-alpha
    R Malaviya
    Department of Pathology, Barnes Jewish Hospital, St Louis, Missouri 63110, USA
    Nature 381:77-80. 1996

Detail Information

Publications360 found, 100 shown here

  1. pmc Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-κB signaling in resident macrophages
    Hosoon Choi
    Texas A and M Health Science Center, College of Medicine, Institute for Regenerative Medicine at Scott and White, Temple, TX 76502, USA
    Blood 118:330-8. 2011
    ..gene 6 protein (TSG-6) and thereby create a negative feedback loop that reduces inflammation in zymosan-induced peritonitis. The results demonstrate for the first time that TSG-6 interacts through the CD44 receptor on resident ..
  2. pmc Resolvin E1 and protectin D1 activate inflammation-resolution programmes
    Jan M Schwab
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 447:869-74. 2007
    ..Together, these results identify new active components for postexudate resolution traffic, and demonstrate that RvE1 and PD1 are potent agonists for resolution of inflamed tissues...
  3. ncbi Transcriptomic analyses of murine resolution-phase macrophages
    Melanie J Stables
    Centre for Clinical Pharmacology and Therapeutics, Division of Medicine, University College London, United Kingdom
    Blood 118:e192-208. 2011
    ..Affymetrix-based transcriptomic analysis of macrophages from the resolution phase of a zymosan-induced peritonitis. Compared with macrophages from hyperinflamed mice possessing a pro-inflammatory nature as well as naive ..
  4. pmc Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 206:15-23. 2009
    ..During the resolution of mouse peritonitis, exudates accumulated both 17-hydroxydocosahexaenoic acid, a known marker of 17S-D series resolvin (Rv) and ..
  5. pmc Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis
    Matthew Spite
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 461:1287-91. 2009
    ..Together, these results identify RvD2 as a potent endogenous regulator of excessive inflammatory responses that acts via multiple cellular targets to stimulate resolution and preserve immune vigilance...
  6. ncbi Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation
    S M Hurst
    Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3US, Wales, United Kingdom
    Immunity 14:705-14. 2001
    ....
  7. pmc Heat shock protein 72 enhances autophagy as a protective mechanism in lipopolysaccharide-induced peritonitis in rats
    Shu Li
    Department of Nephrology, First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    Am J Pathol 179:2822-34. 2011
    Peritoneal dialysis-related peritonitis causes the denudation of mesothelial cells and, ultimately, membrane integrity alterations and peritoneal dysfunction...
  8. pmc Saturated-efferocytosis generates pro-resolving CD11b low macrophages: modulation by resolvins and glucocorticoids
    Sagie Schif-Zuck
    Department of Biology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel
    Eur J Immunol 41:366-79. 2011
    ..evidence for the emergence of pro-resolving, CD11b(low) macrophages in vivo during the resolution of murine peritonitis. These macrophages are distinct from the majority of peritoneal macrophages in terms of their functional ..
  9. pmc Pathophysiological changes to the peritoneal membrane during PD-related peritonitis: the role of mesothelial cells
    Susan Yung
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    Mediators Inflamm 2012:484167. 2012
    ..b>Peritonitis remains a major complication of PD and is a predominant cause of technique failure, morbidity and mortality ..
  10. ncbi Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-alpha
    R Malaviya
    Department of Pathology, Barnes Jewish Hospital, St Louis, Missouri 63110, USA
    Nature 381:77-80. 1996
    ....
  11. ncbi Eosinophils promote resolution of acute peritonitis by producing proresolving mediators in mice
    Tomohiro Yamada
    Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    FASEB J 25:561-8. 2011
    ..The mechanisms by which acute inflammation is resolved are of interest. In murine zymosan-induced peritonitis, we found that eosinophils are recruited to the inflamed loci during the resolution phase of acute inflammation...
  12. ncbi A new strategy for the identification of novel molecules with targeted proresolution of inflammation properties
    Roberta A Navarro-Xavier
    Division of Medicine, Centre for Clinical Pharmacology and Therapeutics, University College London, London, United Kingdom
    J Immunol 184:1516-25. 2010
    ..As an illustration, mice bearing peritonitis induced by 10 mg of zymosan were given ibuprofen, resolvin E1, a prostaglandin D(2) receptor 1 agonist, ..
  13. pmc The antinociceptive and anti-inflammatory activities of caulerpin, a bisindole alkaloid isolated from seaweeds of the genus Caulerpa
    Everton Tenório de Souza
    LaFI Laboratório de Farmacologia e Imunidade, Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Alagoas, Maceió AL, Brazil
    Mar Drugs 7:689-704. 2009
    ..and the hot plate tests, the formalin-induced pain, the capsaicin-induced ear edema and the carrageenan-induced peritonitis. Caulerpin was given orally at a concentration of 100 micromol/kg...
  14. ncbi Rapid recruitment of inflammatory monocytes is independent of neutrophil migration
    Robert B Henderson
    Leukocyte Adhesion Laboratory, Cancer Research United Kingdom London Research Institute, Lincoln s Inn Fields Laboratories, London WC2A 3PX, UK
    Blood 102:328-35. 2003
    ..The murine monocyte therefore responds rapidly to chemokines produced in situ by tissue cells at the site of inflammation with no requirement for prior influx of neutrophils...
  15. ncbi A quantifiable proliferative burst of tissue macrophages restores homeostatic macrophage populations after acute inflammation
    Luke C Davies
    Department of Infection, Immunity and Biochemistry, Cardiff University School of Medicine, Heath Park, Cardiff, UK
    Eur J Immunol 41:2155-64. 2011
    ....
  16. ncbi Bacterial infections in cirrhosis: epidemiological changes with invasive procedures and norfloxacin prophylaxis
    Javier Fernandez
    Liver Unit, IMD, and Department of Microbiology and IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Hepatology 35:140-8. 2002
    ..A total of 405 patients presented 572 bacterial infections in 507 admissions. Spontaneous bacterial peritonitis was the most frequent infection (138 cases)...
  17. ncbi Procalcitonin is not an accurate marker of spontaneous bacterial peritonitis in patients with cirrhosis
    L Spahr
    Division of Gastroenterology and Hepatology, University Hospital, 24 Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Hepatogastroenterology 48:502-5. 2001
    The clinical features of peritonitis are usually absent in cirrhotic patients with an ascitic fluid infection, raising the interest for specific biological markers of inflammation.
  18. ncbi Oral administration of 2-docosahexaenoyl lysophosphatidylcholine displayed anti-inflammatory effects on zymosan A-induced peritonitis
    Nguyen Dang Hung
    College of Pharmacy, Chungnam National University, Yuseong Ku, Taejon, 305 764, Republic of Korea
    Inflammation 34:147-60. 2011
    ..Taken altogether, it is suggested that 2-docosahexaenoyl-lysoPC and its oxygenation products may exert anti-inflammatory action after oral administration...
  19. pmc CD44 deficiency is associated with enhanced Escherichia coli-induced proinflammatory cytokine and chemokine release by peritoneal macrophages
    Gerritje J W van der Windt
    Center of Infection and Immunity Amsterdam, Academic Medical Center, Meibergdreef 9, Room G2 132, 1105 AZ Amsterdam, The Netherlands
    Infect Immun 78:115-24. 2010
    ..b>Peritonitis is an important cause of sepsis, and Escherichia coli is one of the major pathogens involved therein...
  20. ncbi An outbreak of peritonitis caused by multidrug-resistant Salmonella Typhi in Kinshasa, Democratic Republic of Congo
    J J Muyembe-Tamfum
    National Institute for Biomedical Research, Kinshasa, the Democratic Republic of Congo
    Travel Med Infect Dis 7:40-3. 2009
    Between October 2004 and January 2005, 144 patients with peritonitis were admitted to the surgical wards of Kinshasa General Hospital and a few private city clinics...
  21. pmc Increased inflammation and lethality of Dusp1-/- mice in polymicrobial peritonitis models
    Michael Hammer
    Institute of Medical Microbiology, Immunology and Hygiene, Technical University Munich, Munich, Germany
    Immunology 131:395-404. 2010
    ..Here, we have investigated the consequences of Dusp1-deficiency in colon ascendens stent peritonitis (CASP) and caecal ligation and puncture (CLP), two mouse models of septic peritonitis...
  22. ncbi Electrical vagus nerve stimulation and nicotine effects in peritonitis-induced acute lung injury in rats
    Claire Boland
    Department of Critical Care Medicine, Saint Luc University Hospital, Universite Catholique de Louvain, Brussels, Belgium
    Inflammation 34:29-35. 2011
    ..We conducted a prospective, randomized experimental study. Four hours after peritonitis induction by cecal ligation and puncture (CLP), rats were randomized into three groups of seven animals ..
  23. pmc Characterization and modulation of the immunosuppressive phase of sepsis
    Jared T Muenzer
    Department of Pediatrics, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Infect Immun 78:1582-92. 2010
    ..However, by 7 days post-CLP, the host's immune system has recovered sufficiently to mount an effective immune response. Modulation of the immunosuppressive phase of sepsis may aid in the development of new therapeutic strategies...
  24. ncbi Role of fluoroquinolones in the primary prophylaxis of spontaneous bacterial peritonitis: meta-analysis
    Rohit Loomba
    Division of Gastroenterology, University of California at San Diego, La Jolla, California 92093, USA
    Clin Gastroenterol Hepatol 7:487-93. 2009
    The use of antibiotics in the primary prophylaxis for spontaneous bacterial peritonitis (SBP) in patients with cirrhosis is controversial...
  25. ncbi Nosocomial spontaneous bacterial peritonitis and bacteremia in cirrhotic patients: impact of isolate type on prognosis and characteristics of infection
    Bernard Campillo
    Service de Rééducation Digestive, Hopital Albert Chenevier, 94010 Creteil Cedex, France
    Clin Infect Dis 35:1-10. 2002
    The characteristics of and prognosis for nosocomial spontaneous bacterial peritonitis (SBP) and bacteremia were examined in a prospective study that included data from 194 consecutive episodes of SBP and 119 episodes of bacteremia, 93...
  26. ncbi Encapsulating peritoneal sclerosis: incidence, predictors, and outcomes
    David W Johnson
    Australia and New Zealand Dialysis and Transplant Registry, Adelaide, South Australia, Australia
    Kidney Int 77:904-12. 2010
    ..was independently predicted by younger age and the duration of peritoneal dialysis, but not the rate of peritonitis. Twenty-six patients were diagnosed while still on peritoneal dialysis...
  27. ncbi Effect of cholinesterase inhibitor galanthamine on circulating tumor necrosis factor alpha in rats with lipopolysaccharide-induced peritonitis
    Zhi Hai Liu
    Department of Emergency Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine and Research Institute of Emergency Medicine, Hangzhou, Zhejiang 310009, China
    Chin Med J (Engl) 123:1727-30. 2010
    ..This study aimed to evaluate the effect of galanthamine on circulating tumor necrosis factor alpha (TNF-alpha) in rats with lipopolysaccharide-induced peritonitis and the possible role of the vagus nerve in the action of galanthamine.
  28. ncbi Polymicrobial peritonitis in peritoneal dialysis patients in Australia: predictors, treatment, and outcomes
    Katherine Barraclough
    Australia and New Zealand Dialysis and Transplant Registry, Adelaide, Australia
    Am J Kidney Dis 55:121-31. 2010
    The study aim was to examine the frequency, predictors, treatment, and clinical outcomes of peritoneal dialysis-associated polymicrobial peritonitis.
  29. ncbi Defective macrophage migration in Gαi2- but not Gαi3-deficient mice
    Kristina Wiege
    Clinical Department of Immunology and Rheumatology, Hannover Medical School, Hannover, Germany
    J Immunol 189:980-7. 2012
    ..mice exhibited reduced recruitment of macrophages in experimental models of thioglycollate-induced peritonitis and LPS-triggered lung injury...
  30. pmc Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice
    D C Bullard
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Exp Med 183:2329-36. 1996
    ..or without addition of TNF-alpha, and an absence of neutrophil emigration at 4 h in response to intraperitoneal Streptococcus pneumoniae peritonitis. These mice provide strong evidence for the functional importance of selectins in vivo.
  31. ncbi Dietary supplementation with fructooligosaccharides attenuates allergic peritonitis in mice
    Akiko Yasuda
    Meiji Co, Ltd, Nutritionals and Provisions Team, Tokyo, Japan
    Biochem Biophys Res Commun 422:546-50. 2012
    ..the preventive and therapeutic effects of dietary supplementation with FOS on a murine model of allergic peritonitis induced by ovalbumin (OVA)...
  32. ncbi Mechanisms of attenuation of abdominal sepsis induced acute lung injury by ascorbic acid
    Bernard J Fisher
    Division of Pulmonary and Critical Care Medicine, Dept of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298 0050, USA
    Am J Physiol Lung Cell Mol Physiol 303:L20-32. 2012
    Bacterial infections of the lungs and abdomen are among the most common causes of sepsis. Abdominal peritonitis often results in acute lung injury (ALI)...
  33. pmc BLTR mediates leukotriene B(4)-induced chemotaxis and adhesion and plays a dominant role in eosinophil accumulation in a murine model of peritonitis
    A M Tager
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Exp Med 192:439-46. 2000
    ..These studies demonstrate that BLTR is the key receptor that mediates LTB(4)-induced leukocyte activation and establishes a model to decipher the functional roles of BLTR and LTB(4) in vivo...
  34. ncbi Serum and ascitic procalcitonin levels in cirrhotic patients with spontaneous bacterial peritonitis: diagnostic value and relationship to pro-inflammatory cytokines
    A Viallon
    Emergency and Intensive Care Units, Bellevue Hospital, Saint Etienne, France
    Intensive Care Med 26:1082-8. 2000
    To assess the potential role of procalcitonin and pro-inflammatory cytokines, TNF-alpha, and IL-6, in the diagnosis of spontaneous bacterial peritonitis (SBP).
  35. ncbi Jejunal feeding, even when instituted late, improves outcomes in patients with severe pancreatitis and peritonitis
    G Pupelis
    Department of Surgery, Medical Academy of Latvia, theRiga 7th Clinical Hospital
    Nutrition 17:91-4. 2001
    This study assessed the feasibility and effectiveness of jejunal feeding (JF) after surgery due to secondary peritonitis or failed conservative therapy of severe pancreatitis...
  36. ncbi Pretreatment with pro- and synbiotics reduces peritonitis-induced acute lung injury in rats
    Demet Tok
    Department of Anesthesiology, Celal Bayar University, Turkey
    J Trauma 62:880-5. 2007
    To study whether enteral pretreatment with a synbiotic composition of lactic acid bacteria and bioactive fibers can reduce peritonitis-induced lung neutrophil infiltration and tissue injury in rats.
  37. ncbi Therapeutic effects of melatonin on peritonitis-induced septic shock with multiple organ dysfunction syndrome in rats
    Jeng Yuan Wu
    Division of Thoracic Surgery, Taichung Tzu Chi General Hospital, Taichung, Taiwan
    J Pineal Res 45:106-16. 2008
    ..g. melatonin in this study) in conscious rats with peritonitis-induced lethality...
  38. ncbi CAPD peritonitis induces the production of a novel peptide, daintain/allograft inflammatory factor-1
    Annelie Brauner
    Department of Clinical Microbiology and MTC, Karolinska Hospital and Karolinska Institute, Stockholm, Sweden
    Perit Dial Int 23:5-13. 2003
    ..ambulatory peritoneal dialysis (CAPD) patients at commencement and after a follow-up period of therapy and during peritonitis. In addition, we studied peptide production in response to bacterial stimulation of monocytes and macrophages.
  39. ncbi Peritoneal dialysis-associated peritonitis in Scotland (1999-2002)
    David Kavanagh
    The Scottish Renal Registry, Royal Infirmary, Castle Street, Glasgow G4 0SF, UK
    Nephrol Dial Transplant 19:2584-91. 2004
    b>Peritonitis is a major complication of peritoneal dialysis (PD). We have performed a national study of all patients on PD in Scotland over a 3...
  40. ncbi Cecal ligation and puncture versus colon ascendens stent peritonitis: two distinct animal models for polymicrobial sepsis
    Stefan Maier
    Department of Surgery, Ernst Moritz Arndt Universitat, Greifswald, Germany
    Shock 21:505-11. 2004
    Colon ascendens stent peritonitis (CASP) and cecal ligation and puncture (CLP), two animal models designed to closely mimic the clinical course of intra-abdominal sepsis, were compared...
  41. pmc Spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1
    Alexander Zarbock
    Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
    Immunity 26:773-83. 2007
    ..Neutrophil recruitment in a thioglycollate-induced peritonitis model was almost completely inhibited in Selplg(-/-) mice or Syk(-/-) bone-marrow chimeras treated with ..
  42. pmc Renal dysfunction is the most important independent predictor of mortality in cirrhotic patients with spontaneous bacterial peritonitis
    Puneeta Tandon
    Section of Digestive Diseases, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Clin Gastroenterol Hepatol 9:260-5. 2011
    Spontaneous bacterial peritonitis (SBP) is the most common infection among patients with cirrhosis...
  43. pmc Geographic and educational factors and risk of the first peritonitis episode in Brazilian Peritoneal Dialysis study (BRAZPD) patients
    Luis C Martin
    Department of Internal Medicine, Botucatu Medical School, 18618 000 Botucatu, Sao Paulo, Brazil
    Clin J Am Soc Nephrol 6:1944-51. 2011
    b>Peritonitis remains as the most frequent cause of peritoneal dialysis (PD) failure, impairing patient's outcome...
  44. ncbi Higher rate and earlier peritonitis in Aboriginal patients compared to non-Aboriginal patients with end-stage renal failure maintained on peritoneal dialysis in Australia: analysis of ANZDATA
    Wai H Lim
    Renal Unit, Queen Elizabeth Hospital, Adelaide, South Australia, Australia
    Nephrology (Carlton) 10:192-7. 2005
    ..b>Peritonitis accounts for the bulk of these technique failures, but it is uncertain whether the increased risk of ..
  45. ncbi Early enhanced local neutrophil recruitment in peritonitis-induced sepsis improves bacterial clearance and survival
    Florin L Craciun
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 185:6930-8. 2010
    ..02 vehicle versus chemokines). These data demonstrate that early, local treatment with CXC chemokines enhances neutrophil recruitment and clearance of bacteria as well as improves survival in the CLP model of sepsis...
  46. pmc Inflammatory cytokines, angiogenesis, and fibrosis in the rat peritoneum
    Peter J Margetts
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Pathol 160:2285-94. 2002
    b>Peritonitis, a common complication of peritoneal dialysis, is followed by acute changes in the function of the peritoneum. The role of inflammatory cytokines in these processes is not clearly identified...
  47. ncbi Does prevention of intraperitoneal spillage when removing a dermoid cyst prevent granulomatous peritonitis?
    W Kondo
    Department of Obstetrics and Gynaecology, centre hospitalier universitaire de Clermont Ferrand, Polyclinique de l Hotel Dieu, Clermont Ferrand, France
    BJOG 117:1027-30. 2010
    ..under the cyst to prevent intraperitoneal spillage of cyst contents, and subsequent postoperative granulomatous peritonitis. Accidental cyst rupture was more frequent when a total laparoscopic approach was used (26/174 or 15% versus 39/..
  48. pmc The hylEfm gene in pHylEfm of Enterococcus faecium is not required in pathogenesis of murine peritonitis
    Diana Panesso
    Department of Internal Medicine, Division of Infectious Diseases, Center for the Study of Emerging and Reemerging Pathogens, Houston, TX, USA
    BMC Microbiol 11:20. 2011
    ..shown to increase gastrointestinal colonization and lethality of Enterococcus faecium in experimental peritonitis. The hylEfm gene, predicting a glycosyl hydrolase, has been considered as a virulence determinant of hospital-..
  49. ncbi Candida as a risk factor for mortality in peritonitis
    Philippe Montravers
    Département d Anesthesie Réanimation DAR, CHU Bichat Claude Bernard, AP HP, Universite Paris VII, France
    Crit Care Med 34:646-52. 2006
    ..None of the studies that have addressed this issue have clearly distinguished between community-acquired peritonitis and nosocomial peritonitis...
  50. ncbi Encapsulating peritoneal sclerosis in Japan: a prospective, controlled, multicenter study
    Hideki Kawanishi
    Tsuchiya General Hospital, Hiroshima, Japan
    Am J Kidney Dis 44:729-37. 2004
    ..Encapsulating peritoneal sclerosis (EPS) is recognized as a rare but serious complication of peritoneal dialysis (PD). The aim of this study was to determine the incidence, clinical features, and mortality rate of EPS...
  51. pmc Enterocyte-specific epidermal growth factor prevents barrier dysfunction and improves mortality in murine peritonitis
    Jessica A Clark
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    Am J Physiol Gastrointest Liver Physiol 297:G471-9. 2009
    Systemic administration of epidermal growth factor (EGF) decreases mortality in a murine model of septic peritonitis. Although EGF can have direct healing effects on the intestinal mucosa, it is unknown whether the benefits of systemic ..
  52. ncbi Selective inhibition of COX-2 improves early survival in murine endotoxemia but not in bacterial peritonitis
    R C Reddy
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, The University of Michigan Medical School, Ann Arbor, Michigan 48109-0360, USA
    Am J Physiol Lung Cell Mol Physiol 281:L537-43. 2001
    ..These results demonstrate that selective COX-2 inhibition confers early but not long-term benefits without affecting the expression of proinflammatory cytokines or the development of lung inflammation...
  53. ncbi Netrin-1 signaling dampens inflammatory peritonitis
    Valbona Mirakaj
    Department of Anesthesiology and Intensive Care Medicine, Tubingen University Hospital, Eberhard Karls University, Tubingen, Germany
    J Immunol 186:549-55. 2011
    ..To further define alternative adenosine signaling, we examined the role of netrin-1 during acute inflammatory peritonitis. In this article, we report that animals with endogenous repression of netrin-1 (Ntn1(+/-)) demonstrated ..
  54. pmc Rap1a activation by CalDAG-GEFI and p38 MAPK is involved in E-selectin-dependent slow leukocyte rolling
    Anika Stadtmann
    Department of Anesthesiology and Intensive Care Medicine, University of Munster, Munster, Germany Max Planck Institute Münster, Munster, Germany
    Eur J Immunol 41:2074-85. 2011
    ..used different Tat-fusion-mutants and gene-deficient mice in intravital microscopy, autoperfused flow chamber, peritonitis, and biochemical studies...
  55. ncbi Spontaneous bacterial peritonitis--in-hospital mortality, predictors of survival, and health care costs from 1988 to 1998
    P J Thuluvath
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Gastroenterol 96:1232-6. 2001
    OBJECTIVES: Spontaneous bacterial peritonitis (SBP) is a complication of end-stage liver disease with a reported mortality of 30-50%...
  56. pmc Maintenance of granulocyte numbers during acute peritonitis is defective in galectin-3-null mutant mice
    C Colnot
    Unité INSERM 257 ICGM, Paris, France
    Immunology 94:290-6. 1998
    ....
  57. pmc The myeloid 7/4-antigen defines recently generated inflammatory macrophages and is synonymous with Ly-6B
    Marcela Rosas
    Infection, Immunity and Biochemistry, Cardiff University School of Medicine, Cardiff, UK
    J Leukoc Biol 88:169-80. 2010
    ..The definition of the 7/4:Ly-6B antigen will allow further characterization and specific modulation of Ly-6B-expressing cells in vivo...
  58. ncbi Infections in patients with cirrhosis increase mortality four-fold and should be used in determining prognosis
    Vasiliki Arvaniti
    The Sheila Sherlock Liver Centre, and University Department of Surgery, Royal Free Hospital and University College London, London, United Kingdom
    Gastroenterology 139:1246-56, 1256.e1-5. 2010
    ..A staged prognostic model of cirrhosis based on varices, ascites, and bleeding has been proposed. We analyzed data on infections in patients with cirrhosis to determine whether it is also a prognostic factor...
  59. pmc Topical negative pressure in managing severe peritonitis: a positive contribution?
    Amin Ibrahim Amin
    Department of Surgery, Queen Margaret Hospital, Dunfermline, Fife, Scotland KY12 0SU, United Kingdom
    World J Gastroenterol 15:3394-7. 2009
    To assess the use of topical negative pressure (TNP) in the management of severe peritonitis.
  60. pmc Effects of Enterococcus faecalis fsr genes on production of gelatinase and a serine protease and virulence
    X Qin
    Division of Infectious Diseases, Department of Medicine, University of Texas Medical School, Houston, Texas 77030, USA
    Infect Immun 68:2579-86. 2000
    ..Testing of fsrA, fsrB, and sprE mutants in a mouse peritonitis model showed that sprE and agr-like gene mutants resulted in highly significantly prolonged survival compared ..
  61. ncbi Endotoxin-induced chemokine expression in murine peritoneal mesothelial cells: the role of toll-like receptor 4
    Sawako Kato
    Division of Clinical Immunology, Department of Internal Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Am Soc Nephrol 15:1289-99. 2004
    Acute peritonitis, in which peritoneal mesothelial cells are directly exposed to bacterial components, is a major cause of peritoneal dysfunction in continuous ambulatory peritoneal dialysis patients...
  62. ncbi 12/15-Lipoxygenase regulates the inflammatory response to bacterial products in vivo
    Vincent Dioszeghy
    Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Cardiff, United Kingdom
    J Immunol 181:6514-24. 2008
    ..This indicates a selective effect of 12/15-LOX on peritoneal cell cytokine production. In acute sterile peritonitis, 12/15-LOX(+) cells and LOX products were cleared, then reappeared during the resolution phase...
  63. ncbi A multicentre study of antifungal strategies and outcome of Candida spp. peritonitis in intensive-care units
    P Montravers
    département d anesthésie réanimation chirurgicale, Centre Hospitalier Universitaire Bichat Claude Bernard, AP HP, Universite Paris VII, Paris, France
    Clin Microbiol Infect 17:1061-7. 2011
    Information on the species causing Candida peritonitis, their in vitro susceptibility, antifungal strategies in this setting and patient outcome is still scarce...
  64. ncbi Can yeast isolation in peritoneal fluid be predicted in intensive care unit patients with peritonitis?
    Herve Dupont
    Anesthésie Réanimation Chirurgicale, Hopital Bichat Claude Bernard, Paris, France
    Crit Care Med 31:752-7. 2003
    To generate and validate a predictive score of yeast isolation based on independent risk factors of yeast isolation in intensive care unit patients with peritonitis.
  65. ncbi Variables associated with positive findings at relaparotomy in patients with secondary peritonitis
    Oddeke Van Ruler
    Department of Surgery, Academic Medical Center University of Amsterdam, The Netherlands
    Crit Care Med 35:468-76. 2007
    The decision whether and when to perform a relaparotomy in secondary peritonitis is largely subjective and based on professional experience. No existing scoring system aids in this decisional process...
  66. ncbi Ascitic fluid infection in patients with hepatitis B virus-related liver cirrhosis: culture-negative neutrocytic ascites versus spontaneous bacterial peritonitis
    Seung Up Kim
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    J Gastroenterol Hepatol 25:122-8. 2010
    Ascitic fluid infection (AFI) consists of culture-negative neutrocytic ascites (CNNA) and spontaneous bacterial peritonitis (SBP)...
  67. ncbi Small intestinal bacterial overgrowth in patients with cirrhosis: prevalence and relation with spontaneous bacterial peritonitis
    T M Bauer
    Department of Medicine II and Institute of Medical Microbiology and Hygiene, University Hospital, Freiburg, Germany
    Am J Gastroenterol 96:2962-7. 2001
    ..We examined the association of small intestinal bacterial overgrowth with spontaneous bacterial peritonitis and compared various microbiological criteria...
  68. ncbi Changes of cytokine profiles during peritonitis in patients on continuous ambulatory peritoneal dialysis
    K N Lai
    Department of Medicine, Queen Mary Hospital, University of Hong Kong
    Am J Kidney Dis 35:644-52. 2000
    ..One of the major complications is bacterial peritonitis, which may result in subsequent technique failure because of loss of peritoneal clearance or peritoneal ..
  69. ncbi Abdominal catastrophe revisited: the risk and outcome of enteric peritoneal contamination
    Elizabeth O Kern
    Department of Internal Medicine, University Hospitals of Cleveland, Ohio 44106, USA
    Perit Dial Int 22:323-34. 2002
    b>Peritonitis from a visceral source is associated with striking morbidity and mortality in patients treated with peritoneal dialysis (PD). Surgical intervention for both diagnosis and repair is definitive...
  70. ncbi Total synthesis and bioactivity of resolvin E2
    Seiji Ogawa
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Org Lett 11:3602-5. 2009
    ..The synthetic resolvin E2 proved to be biologically active in blocking neutrophil infiltration and reducing proinflammatory cytokines in the acute peritonitis model.
  71. ncbi In-hospital mortality in spontaneous bacterial peritonitis: a new predictive model
    Sónia Rito Nobre
    Unit of Gastroenterology, Hospital Center of Cascais, Cascais, Portugal
    Eur J Gastroenterol Hepatol 20:1176-81. 2008
    Spontaneous bacterial peritonitis (SBP) is a severe complication in cirrhotics with ascites. Early identification of high-risk patients is crucial for prognostic improvement...
  72. pmc Genetic diversity and virulence profiles of Escherichia coli isolates causing spontaneous bacterial peritonitis and bacteremia in patients with cirrhosis
    Frederic Bert
    Service de Microbiologie, Hopital Beaujon, 100 Boulevard du General Leclerc, 92110 Clichy, France
    J Clin Microbiol 48:2709-14. 2010
    ..One hundred ten E. coli isolates from 110 cirrhotic patients with spontaneous bacterial peritonitis and/or spontaneous bacteremia were characterized for their phylogenetic group and virulence genotype (34 ..
  73. pmc 15-epi-lipoxin A4-mediated induction of nitric oxide explains how aspirin inhibits acute inflammation
    Mark J Paul-Clark
    Department of Biochemical Pharmacology, William Harvey Research Institute, St Bartholomew s Hospital and the Royal London School of Medicine and Dentistry, Charterhouse Sq, London EC1M 6BQ, England, UK
    J Exp Med 200:69-78. 2004
    ..in either constitutive (eNOS) or inducible NO synthase (iNOS) knockout mice with IL-1beta-induced peritonitis. It transpires that aspirin generates NO through its unique ability to trigger the synthesis of 15-epi-lipoxin ..
  74. ncbi Imaging features of encapsulating peritoneal sclerosis in continuous ambulatory peritoneal dialysis patients
    Joanna P Ti
    Department of Radiology, Beaumont Hospital, Dublin, Ireland
    AJR Am J Roentgenol 195:W50-4. 2010
    ..The purpose of this article is to present the spectrum of radiologic findings of encapsulating peritoneal sclerosis in patients undergoing continuous ambulatory peritoneal dialysis (CAPD)...
  75. pmc Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury
    Helena Block
    Department of Anesthesiology and Critical Care Medicine, University of Munster, 48149 Munster, Germany
    J Exp Med 209:407-21. 2012
    ..Thus, SLP-76 and ADAP are involved in E-selectin-mediated integrin activation and neutrophil recruitment to inflamed kidneys, which may underlie the development of life-threatening ischemia-reperfusion-induced AKI in humans...
  76. ncbi Value of serum procalcitonin levels in predicting spontaneous bacterial peritonitis
    Dan Hong Su
    Department of Clinical Laboratory, The First Affiliated Hospital of Guangzhou Medical College, China
    Hepatogastroenterology 60:641-6. 2013
    Spontaneous bacterial peritonitis (SBP) is a life-threatening disease that poses a great diagnostic challenge to clinicians...
  77. pmc Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27
    Stefan Wirtz
    Laboratory of Immunology, I Medical Clinic, University of Mainz, 55131 Mainz, Germany
    J Exp Med 203:1875-81. 2006
    ..IL-27 was rapidly induced during murine experimental peritonitis induced by cecal ligation and puncture (CLP)...
  78. ncbi A recent evaluation of empirical cephalosporin treatment and antibiotic resistance of changing bacterial profiles in spontaneous bacterial peritonitis
    Tolga Yakar
    Department of Gastroenterology, Faculty of Medicine, Maremar Medical Center, Baskent University, Ankara, Kahramanmaras, Turkey
    Dig Dis Sci 55:1149-54. 2010
    The aim of this research is to evaluate the recent changes in microorganisms causing spontaneous bacterial peritonitis in cirrhotic patients, antibiotic resistance, and response to empirical cephalosporin therapy...
  79. pmc Adam17-dependent shedding limits early neutrophil influx but does not alter early monocyte recruitment to inflammatory sites
    Jingjing Tang
    Department of Pathology, University of Washington, Seattle, WA 98104, USA
    Blood 118:786-94. 2011
    ..that Adam17-null neutrophils have a 2-fold advantage in their initial recruitment during thioglycollate-induced peritonitis, and they roll slower and adhere more readily in the cremaster model than wild-type neutrophils...
  80. ncbi Severe peritonitis due to Balantidium coli acquired in France
    T Ferry
    Service de Medecine Interne et Maladies Infectieuses, Hôpital de Fleyriat, 01012 Bourg en Bresse, France
    Eur J Clin Microbiol Infect Dis 23:393-5. 2004
    The case reported here concerns an alcoholic pork-butcher who presented with severe colitis with peritonitis, caused by the only ciliate protozoan capable of infecting humans, Balantidium coli...
  81. pmc Pseudomonas peritonitis in Australia: predictors, treatment, and outcomes in 191 cases
    Brian Siva
    Australia and New Zealand Dialysis and Transplant Registry, University of Adelaide at Queen Elizabeth Hospital, Adelaide, South Australia, Australia
    Clin J Am Soc Nephrol 4:957-64. 2009
    Pseudomonas peritonitis is a serious complication of peritoneal dialysis. To date, there as been no comprehensive, multicenter study of this condition.
  82. ncbi Idiopathic sclerosing encapsulating peritonitis in a young female-diagnosis of abdominal cocoon
    Berry Cleffken
    Department of Surgery, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    J Pediatr Surg 43:e27-30. 2008
    ..Explorative laparotomy was performed under suspicion of a proximal jejunal obstruction. Findings at laparotomy were characteristic of abdominal cocoon...
  83. ncbi VAMP8 is essential in anaphylatoxin-induced degranulation, TNF-alpha secretion, peritonitis, and systemic inflammation
    Peter N Pushparaj
    Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore
    J Immunol 183:1413-8. 2009
    ..In this paper, we show that deficiency of VAMP8 protects mice from anaphylatoxin (C5a)-induced neutropenia, peritonitis, and systemic inflammation...
  84. ncbi Long-term vacuum-assisted closure in open abdomen due to secondary peritonitis: a retrospective evaluation of a selected group of patients
    Moritz Schmelzle
    Department of Surgery, University Hospital Dusseldorf, Dusseldorf, Germany
    Dig Surg 27:272-8. 2010
    ..However, little data exist on the role of long-term VAC treatment in patients with peritonitis, where fascial closure cannot be accomplished within the first days.
  85. ncbi Association of proton pump inhibitor therapy with spontaneous bacterial peritonitis in cirrhotic patients with ascites
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, McGuire VA Medical Center, Virginia Commonwealth University, Richmond, Virginia 23221, USA
    Am J Gastroenterol 104:1130-4. 2009
    Spontaneous bacterial peritonitis (SBP) is a frequent complication of cirrhosis. Bacterial contamination of ascites fluid leading to SBP is caused by bacterial translocation with subsequent bacteremia...
  86. ncbi Failure of current antibiotic first-line regimens and mortality in hospitalized patients with spontaneous bacterial peritonitis
    A Umgelter
    2nd Medical Department, Klinikum rechts der Isar, Technical University Munich, Ismaninger Str 22, 81675, Munich, Germany
    Infection 37:2-8. 2009
    ..with Enterobacteriaceae with antimicrobial resistance have been reported in patients with spontaneous bacterial peritonitis (SBP)...
  87. ncbi Patterns of CD4/CD8 T-cell ratio in dialysis effluents predict the long-term outcome of peritonitis in patients undergoing peritoneal dialysis
    Hsin Hui Wang
    Department of Pediatrics, Section of Nephrology, Taipei Veterans General Hospital, and Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan, Republic of China
    Nephrol Dial Transplant 18:1181-9. 2003
    ..subpopulations in peritoneal dialysis effluents (PDEs), and their influence on the response to the treatment of peritonitis and on its prognosis were studied in patients undergoing long-term, continuous ambulatory peritoneal dialysis (..
  88. ncbi Risk factors of first peritonitis episode in Thai CAPD patients
    Dhavee Sirivongs
    Division of Nephrology, Department of Medicine, Faculty of Medicine, Khon Kaen University, Thailand
    J Med Assoc Thai 89:S138-45. 2006
    b>Peritonitis is a major complication of continuous ambulatory peritoneal dialysis (CAPD) patients. Information on the specific risk of peritonitis is important in reducing this common complication.
  89. ncbi Remote indigenous peritoneal dialysis patients have higher risk of peritonitis, technique failure, all-cause and peritonitis-related mortality
    Wai H Lim
    Department of Renal Medicine, Sir Charles Gairdner Hospital, Perth, Australia
    Nephrol Dial Transplant 26:3366-72. 2011
    ..The aim of this study is to examine the association between race and PD outcomes stratified by location...
  90. ncbi Toll-like receptor (TLR) 2 promoter and intron 2 polymorphisms are associated with increased risk for spontaneous bacterial peritonitis in liver cirrhosis
    H D Nischalke
    Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany
    J Hepatol 55:1010-6. 2011
    ..Since they may contribute to susceptibility to spontaneous bacterial peritonitis (SBP), we studied the effects of TLR2 gene variants on susceptibility for SBP in relation to the previously ..
  91. pmc The role of virulence factors in the outcome of staphylococcal peritonitis in CAPD patients
    Pasqual Barretti
    Department of Microbiology and Immunology, Biosciences Institute, UNESP, Botucatu, Sao Paulo, Brazil
    BMC Infect Dis 9:212. 2009
    b>Peritonitis continues to be the most frequent cause of peritoneal dialysis (PD) failure, with an important impact on patient mortality...
  92. ncbi Reduced residual renal function is a risk of peritonitis in continuous ambulatory peritoneal dialysis patients
    Seung Hyeok Han
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    Nephrol Dial Transplant 22:2653-8. 2007
    ..However, the role of RRF on peritonitis is not yet clearly established. This study aimed to evaluate the effect of RRF on the development of peritonitis...
  93. ncbi Characteristics of clinical sepsis reflected in a reliable and reproducible rodent sepsis model
    Falk A Gonnert
    Center for Sepsis Control and Care CSCC, Jena University Hospital, Jena, Germany
    J Surg Res 170:e123-34. 2011
    Sepsis models are frequently based on induction of peritonitis, with cecal ligation and puncture reflecting the prototypical model...
  94. ncbi Staphylococcus aureus peritonitis complicates peritoneal dialysis: review of 245 consecutive cases
    Cheuk Chun Szeto
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Clin J Am Soc Nephrol 2:245-51. 2007
    b>Peritonitis that is caused by Staphylococcus aureus is a serious complication in peritoneal dialysis (PD), but the clinical course of PD-related S. aureus peritonitis remains unclear. All of the S...
  95. ncbi beta-Blockers protect against spontaneous bacterial peritonitis in cirrhotic patients: a meta-analysis
    Marco Senzolo
    The Royal Free Sheila Sherlock Liver Centre, Department of Surgery, London, UK
    Liver Int 29:1189-93. 2009
    ..The aim of our study was to evaluate the possible role of beta-blockers in preventing spontaneous bacterial peritonitis (SBP) in patients with liver cirrhosis and ascites.
  96. ncbi Clinical predictors of ongoing infection in secondary peritonitis: systematic review
    Bas Lamme
    Department of Surgery, Academic Medical Center, Meibergdreef 9, 1105 AZ, The Netherlands
    World J Surg 30:2170-81. 2006
    The decision to perform a relaparotomy in patients with secondary peritonitis is based on "clinical judgment" with inherent variability among surgeons...
  97. ncbi Development of an experimental model of induced bacterial peritonitis in cirrhotic rats with or without ascites
    Elisabet Sánchez
    Liver Unit, Hospital de la Santa Creu i Sant Pau, Autonomous University, Barcelona, Spain
    Am J Gastroenterol 102:1230-6. 2007
    Spontaneous bacterial peritonitis (SBP) is a severe complication of cirrhotic patients associated with a high mortality.
  98. ncbi Surgical approaches to peritonitis
    M A Boermeester
    Department of Surgery, Academic Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Br J Surg 94:1317-8. 2007
  99. pmc Clinical characteristics of dialysis related sclerosing encapsulating peritonitis: multi-center experience in Korea
    Beom Seok Kim
    Division of Nephrology, Department of Internal Medicine, Institute of Kidney Disease, Yonsei University College of Medicine, 134 Shinchon dong, Seodaemun gu, Seoul 120 752, Korea
    Yonsei Med J 46:104-11. 2005
    Sclerosing encapsulating peritonitis (SEP) is a rare but serious complication in patients with continuous ambulatory peritoneal dialysis (CAPD), and is characterized by a progressive, intra-abdominal, inflammatory process resulting in ..
  100. ncbi Intestinal obstruction due to idiopathic sclerosing encapsulating peritonitis. Clinical report and review of literature
    V Minutolo
    Dipartimento Scienze Chirurgiche, Trapianti d Organo, Universita degli Studi di Catania
    G Chir 29:173-6. 2008
    The sclerosing peritonitis (SP) is a rare illness secondary to the peritoneal dialysis or due to intraperitoneal chemotherapy or the positioning of a peritoneal-jugular shunt in cirrhotic patient with refractory ascites or due to unknown ..
  101. ncbi Successful treatment of life-threatening Candida peritonitis in a child with abdominal non-Hodgkin lymphoma using Efungumab and amphotericin B colloid dispersion
    Zdenka Krenova
    Departments of Pediatric Oncology, University Hospital Brno, Czech Republic
    J Pediatr Hematol Oncol 32:128-30. 2010
    ..present a case report of a 12-year-old boy diagnosed with abdominal non-Hodgkin lymphoma and fecal and Candida peritonitis during induction chemotherapy...

Research Grants62

  1. The Role of Carboxypeptidase B and its Substrates in Rheumatoid Arthritis
    William H Robinson; Fiscal Year: 2013
    ..CPB deficient mice exhibited increased leukocyte chemotaxis in an acute peritonitis model, and in vitro chemotaxis assays showed that thrombin-cleaved OPN and C5a act as chemoattractants...
  2. Eukaryotic-type STK/STP-mediated modulation of enterococcal pathogenesis
    Vijay Pancholi; Fiscal Year: 2010
    ..the impact on the enterococcal virulence will be elucidated by determining the ability of efSTK mutant to cause peritonitis in mouse and endocarditis in the rat animal infection models...
  3. Regulation of Leukocyte Migration by Plasminogen
    JANE LEE HOOVER-PLOW; Fiscal Year: 2013
    ..Utilizing Plg deficient (Plg-/-) mice in peritonitis and abdominal aortic aneurysm (AAA) models, our studies provide in vivo evidence that Plg/plasmin is required ..
  4. Characterization of the NOD2 NBD domain and role in chronic inflammation
    Jae W Dugan; Fiscal Year: 2013
    ..Mutations in NOD2 are linked to Crohn's disease, sarcoidosis, asthma, atopy, peritonitis, graft- versus-host disease, leprosy and Blau syndrome (chronic granulomatous inflammation of the skin, eyes, ..
  5. Systems Biology of Glycosylation
    Sriram Neelamegham; Fiscal Year: 2013
    ..v) Validation in animal models of inflammation, peritonitis and COPD (chronic obstructive pulmonary disease), key hypothesis generated using computer simulation and ex ..
  6. Novel Small Molecule Agonists of Integrin CD11b/CD18 as Anti-Inflammatory Agents
    Vineet Gupta; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Infiltration of leukocytes potentiates peritonitis, renal ischemia-reperfusion injury, a major cause of acute renal failure, and other acute inflammatory conditions...
  7. Mechanisms of a Novel Chemotactic Cofactor for C5a
    Richard R Kew; Fiscal Year: 2011
    ..This aim will investigate the role of DBP in immune complex mediated (I) peritonitis, (II) alveolitis, (III) alveolitis induced by C-activated serum and purified C5a, and (IV) in vitro using ..
  8. HS1 Function in Dendritic Cells
    Deborah A Klos Dehring; Fiscal Year: 2010
    ..be monitored to lymphoid organs by fluorescently labeling DCs in ear skin and to sites of inflammation in a peritonitis model...
  9. Sphingolipid Signaling in Endothelial Responses to Injury
    TERESA SANCHEZ GARCIA-VAO; Fiscal Year: 2013
    ..will be used to study the role of S1P2R and PTEN in the regulation of endothelial inflammation in a mouse peritonitis model...
  10. Role of TLR-cfB Signaling in Sepsis
    Wei Chao; Fiscal Year: 2013
    ..and that animals deficient in TLR2 have markedly improved cardiac function and survival in polymicrobial peritonitis sepsis. MyD88, but not Trif, is essential in polymicrobial sepsis-induced cardiac dysfunction and mortality...
  11. CLASSICAL AND ALTERNATIVE PATHWAYS OF FIBRINOLYSIS
    EDWARD FRANKLIN PLOW; Fiscal Year: 2013
    ..responses involving inflammatory cell recruitment in which plasminogen and Plg-Rs have been implicated include peritonitis, sepsis, lung injury, angiogenesis, restenosis, atherogenesis, aneurysm and the response to biomaterial ..
  12. PATHOGENESIS AND TREATMENT OF EXPERIMENTAL PERITONITIS
    Henri R Ford; Fiscal Year: 2013
    ..b>Peritonitis can lead to impairment of the gut barrier resulting in translocation of pathogens across the intestinal mucosa, ..
  13. Mechanisms of Neutrophil Activation
    Clifford A Lowell; Fiscal Year: 2013
    ..defective neutrophil function, stim1-/- chimeras are protected from tissue injury in the zymosan model of acute peritonitis and show significantly reduced tissue injury in a hepatic ischemia reperfusion model...
  14. Therapeutic factor XI blockade for sepsis
    ERIK IAN contact TUCKER; Fiscal Year: 2010
    ..FXI deficiency improves the survival of experimental polymicrobial peritonitis in mice, and preliminary data suggest that anticoagulation by antibody inhibition of FXI produces similar ..
  15. Suppression of T cell immunity during sepsis
    Thomas S Griffith; Fiscal Year: 2013
    ..Using a cecal-ligation and puncture (CLP) model to induce intra-abdominal peritonitis, we recently established a mechanistic link between apoptotic cells generated during sepsis and the ..
  16. Intrathoracic Pressure Regulation for the Treatment of Septic Shock
    Keith Lurie; Fiscal Year: 2009
    ..animal study to demonstrate significant hemodynamic benefit and improved 24 hour survival in a porcine model of peritonitis, 2) an animal study to demonstrate that microcirculation, renal function, and cardiac function can be improved ..
  17. Cell Surface Receptors on T Cells and Macrophages
    CORNELIS P TERHORST; Fiscal Year: 2013
    ..Slamf1 is also a key contributor to murine colitis and peritonitis by affecting monocyte migration to sites of inflammation...
  18. Therapeutic factor XI blockade for sepsis
    ERIK IAN TUCKER; Fiscal Year: 2013
    ..that anticoagulation with our universal anti-FXI antibody 14E11 improves the survival of polymicrobial peritonitis in mice, while reducing the inflammatory and coagulation responses to sepsis, and our Phase II preliminary ..
  19. IQGAP1 In Vascular Barrier Regulation During Acute Lung Injury
    Mallar Bhattacharya; Fiscal Year: 2013
    ..have a similar barrier protective function in clinically relevant in vivo models, including polymicrobial peritonitis due to cecal ligation and puncture, Klebsiella peritonitis, Klebsiella pneumonia, and ventilator induced lung ..
  20. Defining the Role of WxL Proteins in Enterococcus faecium
    JESSICA RHEA GALLOWAY-PENA; Fiscal Year: 2013
    ..Proteins containing this domain have been implicated as important in peritonitis infections caused by Enterococcus faecalis and aggregation in Lactobacillus coryniformis...
  21. Signal transduction in neutrophil chemotaxis
    Hongbo R Luo; Fiscal Year: 2010
    ..the contribution of lns(1,3,4,5)P4 to neutrophil chemotaxis in live animals will be investigated using a mouse peritonitis model and a dorsal air pouch model (Aim III)...
  22. The Impact of the MELD Score at the Time of Listing for Liver Transplantation
    Alyson N Fox; Fiscal Year: 2010
    ..a complication of portal hypertension prior to listing (hyponatremia, refractory ascites, spontaneous bacterial peritonitis, variceal hemorrhage, or encephalopathy of sufficient severity to require hospitalization)...
  23. Novel Mechanisms and Approaches to Treat Neonatal Sepsis
    Lyle L Moldawer; Fiscal Year: 2013
    ..We will use a neonatal mouse model of polymicrobial peritonitis (sepsis) that we have developed and validated, and evaluate the importance of TRIF signaling and CXCL10 through ..
  24. Hemostatic Factors as Determinants of Bacterial Virulence and Host Defense.
    Jay L Degen; Fiscal Year: 2010
    ..aureus peritonitis (Aim 3)...
  25. Protective and Deleterious Roles of Regulated Exocytosis from Mast Cells
    Roberto Adachi; Fiscal Year: 2010
    ..Second, using models of allergic asthma, inflammatory arthritis, and of bacterial peritonitis and pneumonia, we plan to determine which important pathophysiological roles of mast cells depend on their ..
  26. Regulation of neutrophil function and inflammation by ADAM17 during infection
    Bruce K Walcheck; Fiscal Year: 2010
    ..coli-mediated peritonitis we show that ADAM17 modulates neutrophil tissue infiltration, E...
  27. TLR2 in Sepsis-Induced Coagulopathy, Endothelial Leak, and Pulmonary Dysfunction
    Judith Hellman; Fiscal Year: 2010
    ..Sepsis will be induced in mice using peritonitis and pneumonia models...
  28. Role of IRAK-M in sepsis-induced immunosuppression
    Jane C Deng; Fiscal Year: 2010
    ..To test this hypothesis, these studies will employ a murine model of polymicrobial peritonitis-induced sepsis [cecal ligation and puncture (CLP) model] in both wildtype and IRAK-M knockout mice...
  29. Enterococcus faecium virulence: A molecular and therapeutic approach
    CESAR AUGUSTO ARIAS; Fiscal Year: 2010
    ..a large plasmid carried by clinical isolates of Efm, which confers increased virulence in experimental peritonitis and indicated that a gene (designated hylEfm and encoding a putative glycosyl hydrolase), which was the focus ..
  30. Molecular basis of neutrophil spontaneous death
    Hongbo R Luo; Fiscal Year: 2010
    ..of Ptdlns(3,4,5)P3/Akt pathway to neutrophil death in live animals will be investigated using a mouse peritonitis model (Aim III)...
  31. Role of Cyclooxygenase-2-derived Prostanoids in Polymicrobial Sepsis
    LAURA ELIZABETH FREDENBURGH; Fiscal Year: 2012
    ..Our preliminary data demonstrate that COX-2 deficiency is detrimental in a murine model of peritonitis-induced polymicrobial sepsis...
  32. A novel Anti-endotoxin Peptide for Septic Shock
    Xiao Jia Chang; Fiscal Year: 2010
    ..The potential therapeutic applications may include treatment for patients with peritonitis, sepsis, and/or septic shock. *Angus D, et al. Crit Care Med 2001;29(7): 1303-1310...
  33. PARP inhibitor therapy for septic shock
    Andrew Salzman; Fiscal Year: 2004
    ..coli-induced peritonitis and septic shock, when administered AFTER the initiation of infection and onset of hemodynamic instability...
  34. Molecular Etiology of Familial Mediterranean Fever
    Deborah Gumucio; Fiscal Year: 2007
    ..of fever associated with severe pain; the pain is localized most commonly in joints (arthritis), abdomen (peritonitis) or chest (pleuritis)...
  35. ROLE OF AEROMONAS HYDROPHILA VIRULENCE FACTORS
    CLIFFORD HOUSTON; Fiscal Year: 1992
    ..a variety of diseases including acute bacterial diarrhea, septicemia, meningitis, endocarditis, corneal ulcers, peritonitis, and wound infections. These diseases have occurred in immunocompetent and immunocompromised individuals. A...
  36. GI MYOELECTRIC ACTIVITY--MATURATION AND FUNCTION
    Joanne Szabo; Fiscal Year: 1993
    ..S. infants annually, is leading cause of surgical emergency in neonates, and leads to death from peritonitis and overwhelming sepsis in 28-41% of cases...
  37. Dynamics of Peritoneal Dialysis Associated Peritonitis
    John Hotchkiss; Fiscal Year: 2004
    ..dynamics of bacterial growth and optimal bacterial clearance in the setting of peritoneal dialysis associated peritonitis (PDAP)...
  38. E COLI PATHOGENICITY ISLANDS
    RODNEY WELCH; Fiscal Year: 1999
    ..identified thus far and then test these mutants in murine models of ascending urinary tract infection and peritonitis; 2...
  39. PRECLINICAL EVAL. OF THERAPIES FOR MICROSPORIDIAL INFECT
    ELIZABETH DIDIER; Fiscal Year: 2000
    ..diarrhea, and other clinical manifestations that may include keratitis, nephritis, pneumonia, hepatitis, peritonitis, and sinusitis. Gastrointestinal infections comprise the vast majority of microspordiosis cases...
  40. NC/OFQ analogs as ORL1 agonists to promote gut motility
    MARK FINDEIS; Fiscal Year: 2005
    ..POI may also lead to clinically dangerous conditions, bowel perforation may lead to peritonitis, septacaemia and mortality...
  41. Mast Cells and the Host Response in the Lung
    Paul Wolters; Fiscal Year: 2007
    ..that the mast cell protease dipeptidyl peptidase I (DPPI) contributes to death of the host from septic peritonitis and that it appears to do so by regulating levels of mast cell IL-6...
  42. NEUTROPHIL SEQUESTRATION AND EMIGRATION IN THE LUNG
    CLAIRE DOERSCHUK; Fiscal Year: 2001
    ..neutrophils migrate between them and the role of VLA-4 and VCAM-1 in neutrophil emigration during pneumonia and peritonitis. These studies will help to understand biomechanical and adhesive events and their interactions during ..
  43. The Lung as a Source of Inflammation in Sepsis
    Edmund Miller; Fiscal Year: 2009
    ..Septic peritonitis and recombinant MIF, in normal animals and in animals in which the MIF gene has been deleted (either totally, ..
  44. Mechanisms of a Novel Chemotactic Cofactor for C5a
    RICHARD KEW; Fiscal Year: 2007
    ..This aim will investigate the role of DBP in immune complex mediated (I) peritonitis and (II) alveolitis, (III) alveolitis induced by C-activated serum and purified C5a, and (IV) in vitro using ..
  45. BODY TEMPERATURE AND REGULATING HOST DEFENSES
    Jeffrey Hasday; Fiscal Year: 2001
    ..pneumoniae peritonitis; (2) determine if increasing core temperature to febrile levels enhances collateral tissue injury during K...
  46. NEUTROPHILS AND STAPHYLOCOCCUS AUREUS
    Hattie Gresham; Fiscal Year: 2004
    ..aureus infection. However, our studies of S. aureus-induced peritonitis and sepsis in mice have suggested that PMN have both a protective and a deleterious role...
  47. Commercialization of Human Omental Mesothelial Cells for Research
    YOLANDA LEA CURRIE; Fiscal Year: 2007
    ..this currently unavailable system will provide wider opportunity to investigate novel methods to inhibit ovarian tumor attachment, prolong the utility of peritoneal dialysis, and treat peritonitis. [unreadable] [unreadable] [unreadable]
  48. CAPSULAR POLYSACCHARIDES AND ENTEROCOCCAL INFECTIONS
    Johannes Huebner; Fiscal Year: 2002
    ..A mouse peritonitis/sepsis model and a neonatal mouse model will be used to evaluate the effectiveness of antibodies specific for ..
  49. Commercialization of Human Mesothelial Cells for Research
    YOLANDA RENEE LEA CURRIE; Fiscal Year: 2010
    ..The accessibility of this currently unavailable system will provide wider opportunity to investigate novel methods to inhibit ovarian tumor attachment, prolong the utility of peritoneal dialysis, and treat peritonitis.
  50. COMPLEMENT C3 AND ACQUIRED AND INNATE IMMUNITY
    Michael Carroll; Fiscal Year: 2003
    ..A murine model of acute septic peritonitis which is mast cell and classical pathway complement dependent will be used to examine the mechanisms of ..
  51. Selectins and their ligands in leukocyte trafficking
    Erik Vandendries; Fiscal Year: 2005
    ..An experimental model of mouse peritonitis will be used to examine neutrophil accumulation during inflammation...
  52. Pyrin in Arthritis: Exression and Modulatory Role
    Arturo Diaz; Fiscal Year: 2004
    ..3: To determine whether wild type pyrin modulates inflammation and/or apoptosis in experimental arthritis and peritonitis produced in mouse models (mice that over-express human pyrin; pyrin deficient mice; mice in which the ..
  53. Macrophage Pericellular Proteinase Cascade
    DOMENICK FALCONE; Fiscal Year: 2007
    ..the effect of annexin II deficiency on macrophage recruitment in vivo utilizing thioglycollate-induced peritonitis and foreign body-induced granuloma models and recruitment to atherosclerotic lesions in Apo E-/- IAnx II-/- ..
  54. IMMUNOTHERAPY DURING GRAM-NEGATIVE BACTERIAL SEPSIS
    David Dunn; Fiscal Year: 1992
    ..capacity by exact LD50 calculations in three murine sepsis models: (1) iv bacteremia, (2) ip hemoglobin peritonitis, and (3) iv endotoxemia...
  55. GENETIC CONTRIBUTION TO THE STRESS RESPONSE
    Antonio De Maio; Fiscal Year: 2002
    ..coli LPS, and peritonitis induced by cecal ligation and puncture (CLP)...
  56. ABC TRANSPORTERS AND PATHOGENECITY OF CANDIDA ALBICANS
    GERWALD KOHLER; Fiscal Year: 2004
    ..albicans is crucial for its invasion of parenchymal organs in a peritonitis model...
  57. OCULAR/SYSTEMIC MICROSPORIDIOSIS OF AIDS PATIENTS
    JOHN SHADDUCK; Fiscal Year: 1992
    ..Debilitating clinical symptoms include keratitis, diarrhea, peritonitis, and hepatitis. Definitive diagnosis of microsporidiosis depends upon electron microscopic examination...
  58. SHOCK IN INFANCY: METABOLIC AND HEMODYNAMIC ASPECTS
    MARC ROWE; Fiscal Year: 1980
    ..oxygen tension in clinically encountered low-flow states and 2) to attempt to base the resuscitation regime of peritonitis on a physiologic basis by investigating albumin kinetics in the normal state and during peritonitis and ..
  59. PROTECTION DURING GRAM NEGATIVE BACTERIAL SEPSIS
    David Dunn; Fiscal Year: 2002
    ..mice devoid of either TNFR1, IL-1R1, or both in conjunction with the above mentioned reagents will be used to examine the relative roles of TNFa and IL-1 signalling during endotoxemia and gram-negative bacteremia and peritonitis.
  60. CONTINUOUS AMBULATORY PERITONEAL DIALYSIS (CAPD)
    Dimitrios Oreopoulos; Fiscal Year: 1980
    ..The specific aims of this program will be: to develop means to decrease the high incidence of peritonitis associated with this mode of therapy; to define a mode of therapy acceptable from the medical (blood chemistry, ..
  61. A2A ADENOSINE AGONISTS LIMIT DAMAGE FROM INFECTION
    Robert Thompson; Fiscal Year: 2003
    ..Aim 3 will optimize treatment regimens with ATL146e in a mouse model of E. coli peritonitis and bacteremia...
  62. A2A ADENOSINE AGONISTS LIMIT DAMAGE FROM INFECTION
    WILLIAM SCHELD; Fiscal Year: 2000
    ..potent inhibition of while cell accumulation in animal models of meningitis, infectious arthritis, and peritonitis. The first goal of this proposal is to synthesize new A2A agonists that are optimized in terms of potency, ..